JP5924002B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a technique for effectively preventing pain caused by hypersensitivity and toothing. More specifically, the present invention is excellent in the effect of suppressing the above-mentioned pain due to potassium salt, and the foaming property and spinnability of the preparation are good, and the taste is unpleasant. The present invention relates to a dentifrice composition particularly suitable as a toothpaste.

  Dentin hypersensitivity refers to a painful sensation that is felt transiently when an external stimulus (relatively strong sweetness, acidity, heat, low temperature, pressure) is applied to the root surface of the dentin. Exogenous stimuli are transmitted to the pulpal nerve through the innumerable dentinal tubules present in the dentin, and cause dentin hypersensitivity. In order to develop hypersensitivity of the dentine, it is premised that the dentin at the root portion is exposed by gingival retraction, and the dentinal tubules existing on the surface of the exposed dentin are in a wide open state. Dentin hypersensitivity can be alleviated or prevented by narrowing or blocking the dentinal tubule or its opening, or reducing the sensitivity of the pulpal nerve.

  When suffering from hypersensitivity of dentin, sufficient tooth brushing is hampered to avoid the pain sensation, resulting in insufficient plaque removal. As a result, various troubles such as caries, periodontal disease, calculus deposition and bad breath are caused. In addition, the intake of hot or cold foods is restricted, which adversely affects the eating habits. Therefore, improving and preventing dentin hypersensitivity in daily oral care is important for maintaining oral health.

  Various techniques have been implemented or proposed as techniques for alleviating or preventing dentin hypersensitivity. As a treatment method in a dental clinic, for example, a treatment for sealing dentinal tubules with an adhesive resin or the like is performed. On the other hand, as self-care in the home, for example, a dentifrice composition containing an effective ingredient effective for alleviating or preventing dentin hypersensitivity is commercially available.

There are generally two approaches to techniques for reducing or preventing dentin hypersensitivity through self-care.
The first approach is a technique for constricting and sealing dentinal tubules. For example, a technique in which aluminum lactate or the like is blended and a fluorine compound is blended (see Patent Documents 1 to 3), stannous fluoride is blended. Techniques (see Patent Documents 3 and 4), techniques in which strontium chloride is blended (see Patent Documents 5 and 6), techniques in which an oxalic acid compound is blended (see Patent Documents 7 and 8), and the like have been proposed.
The second approach is a technique for relieving and preventing dentin hypersensitivity by blunting the nerves present in the dental pulp. For example, a technique containing potassium nitrate (see Patent Documents 9 and 10), potassium citrate was added. Techniques (see Patent Documents 11 and 12) are known. Potassium ions have the effect of blunting the pulpal nerve, and the potassium ions reach the pulp and alleviate the sensitivity to dentin. In addition, a technique in which hydrolyzed silk, condensed phosphate, and fluorine are blended to effectively narrow and seal the dentinal tubule is known (see Patent Document 13).

  As a technique for constricting and sealing the dentinal tubule, which is the first approach technique, in the technique related to aluminum lactate, further improvement of the feeling of use such as astringency of the mucous membrane and unpleasant taste due to aluminum ions has been an issue. The technology related to fluorine compounds such as sodium fluoride and sodium monofluorophosphate had problems such as inadequate effect on alleviating dentine hypersensitivity and improvement of deposition of fluorine compounds on dentin. . In the technology related to stannous fluoride, although there is a certain relaxation effect, there is a problem of further improvement in the feeling of use due to the problem of astringency of the mucous membrane due to tin ions, and stannous fluoride forms an insoluble precipitate. Therefore, since the drug efficacy is easily deactivated in the preparation, there remains a problem of stabilizing it. In the technology related to strontium chloride, a sufficient medicinal effect cannot be obtained unless strontium chloride is added at a high concentration, for example, about 10% by mass. In the technology related to acid compounds, calcium oxalate is deposited on the tooth surface other than the affected part after use, and a rough feeling is seen on the tooth surface, and there remains a problem of improving this.

As a second approach technique, a technique relating to potassium nitrate and potassium citrate is known as a technique for relieving and preventing dentin hypersensitivity by blunting nerves. In the case of potassium nitrate, 5% by mass is added to a dentifrice. In some cases, its effectiveness has been confirmed in clinical trials.
However, with these second approach techniques, potassium ions must reach the pulp, but there are individual differences in the distance to the pulp, and the degree of reach also varies depending on the type of teeth, so the effect has not appeared. It was a problem that individual differences greatly affected. Moreover, although the effect | action can be improved by increasing the compounding quantity of potassium, in this case, a bad taste becomes strong, and it was a problem that foaming fell by increasing the amount of inorganic salts.
Therefore, the development of a new technique that works more efficiently without blending a large amount of potassium salt in the second approach technique has been desired.

  On the other hand, the dentifrice composition contains sodium ions as a compounding component, for example, an anionic surfactant as a foaming agent, a counter ion of an ionic group of an amphoteric surfactant, or a neutralized salt in the production process. Further, sodium ions are also included as a counter ion of a polymer having an anionic group used as a binder, and sodium ions are unintentionally included in the composition as a salt. For this reason, typical dentifrice compositions contain at least about 0.2-0.3% by weight of sodium ions.

As a technique for controlling the content of sodium ions in the oral composition, for example, an anionic surfactant, potassium ion, and further containing sodium ions, the composition for oral cavity that has little increase in viscosity when stored at low temperatures and has excellent usability. (Patent Document 14) An organic acid and / or an inorganic acid, a fluorine ion supply compound, an anionic surfactant, potassium ion, and sodium ion, thereby forming a light scattering layer in the tooth enamel layer. The composition for oral cavity (Patent Document 15), anionic surfactant and potassium ion, nonionic surfactant, and sodium ion are blended, so that it has an appropriate viscosity at room temperature, does not sag, and is stored at low temperature. There has been proposed an oral composition (Patent Document 16) and the like that have little viscosity increase at the time and good extrudability from a tube.
However, these are techniques for improving the storage stability and feeling of use of the oral composition, and are not alleviating or preventing dentin hypersensitivity.

JP 2003-026556 A JP 2003-073246 A JP 07-291844 A JP-T-2002-538192 Special Table 2002-505261 Japanese translation of PCT publication No. 2004-506663 JP 2000-281551 A Special Table 2002-505261 Special table 2004-525190 gazette JP-T-2002-512177 JP-T-2006-506436 Special table 2004-525190 gazette JP 2009-155216 A JP 2004-244391 A Japanese Patent Application Laid-Open No. 2004-224779 JP 2005-162701 A

  Therefore, in the second approach technology to alleviate or prevent dentinal hypersensitivity, it works efficiently without adding a large amount of potassium salt, enhances the function of blunting nerves present in the dental pulp, and excellent dentinal perception It has been a challenge to develop an alleviation / suppression effect of hypersensitivity.

  The present invention has been made in view of the above circumstances, and aims to provide a more effective technique for alleviating or preventing hypersensitivity by the above-mentioned second approach. An object of the present invention is to provide a dentifrice composition that is highly effective in suppressing perception hypersensitivity that suppresses pains caused by squeezing, has no taste nuisance due to potassium ions, and has good foaming and spinnability of the preparation.

As a result of intensive studies to achieve the above object, the present inventors have found that the ratio of potassium ions to sodium ions in the composition is 11 or more in terms of mass ratio, and the potassium ion concentration is 1.7 to 3% by mass. There, a betaine-based amphoteric surfactant 0.7 to 1.5% by weight, xanthan gum, 0.8-1.6 mass of one or more polymer compounds selected from hydroxyethyl cell row scan and propylene glycol alginate %, It is excellent in suppressing hypersensitivity by suppressing the pain of toothing due to hypersensitivity of dentin, and has no taste of potassium ions and good foaming. The inventors have found that a dentifrice composition having no problem in properties can be obtained, and have completed the present invention.

  More specifically, the present inventors surprisingly more effectively suppress the pain of tooth dentin hypersensitivity by increasing the potassium ion concentration above a certain value relative to the sodium ion concentration. It was found that this is possible. Furthermore, as a result of diligent studies to use this knowledge for a dentifrice composition, the concentration ratio is set to a certain value or more, and an amphoteric surfactant and a specific polymer compound are appropriately blended. Even if the amount is not increased, the working efficiency is improved, the effect of suppressing the above-mentioned pain due to potassium ions is increased, and good foaming is obtained as a usability of the dentifrice composition. It has been found that the lack of spinnability, which is a factor of kneading that can be efficiently collected, can be ensured, and therefore the hypersensitivity of dentin can be more effectively reduced or prevented by the second approach described above.

  In the dentifrice composition, it is necessary to adjust the type and content of the component that supplies sodium ion in order to control the amount of sodium ion, but such adjustment affects the usability, Adjusting the type and content of the anionic binder increases the spinnability of the dentifrice formulation, and in particular, the new formulation has a new problem that it is inferior to kneading when extruded, but according to the present invention, the amphoteric interface It has been found that the combination of an activator and a specific polymer compound eliminates such a problem and exhibits the above-mentioned special effects.

  It is not clear why increasing the concentration ratio of potassium ion and sodium ion to the potassium side can suppress the pain caused by hypersensitivity to dentin, but since both potassium and sodium are alkali metals, In order to blunt, it is necessary to act on the pulp nerve site, but it is assumed that one of the factors is that potassium ions that have an effect on that site compete with other sodium ions Is done.

  In addition, in the prior art, there is no description of the combination covering the configuration of the present invention, and the effect of alleviating and preventing dentin hypersensitivity caused by potassium ions is increased by controlling the amount ratio of potassium and sodium. There is no description that reminds me of this.

  In the present invention, by further containing aluminum lactate, the pain caused by hypersensitivity to the dentin is further suppressed without impairing the effects of the present invention, and an excellent suppression effect is obtained.

  Furthermore, in the present invention, by containing sucralose and / or aspartame, an unpleasant taste due to a high salt concentration can be more effectively suppressed.

Accordingly, the present invention provides the following dentifrice composition.
[1]
The ratio of potassium ions to sodium ions in the composition is 11 or more as a mass ratio, the potassium ion concentration is 1.7 to 3% by mass, and the betaine amphoteric surfactant is 0.7 to 1.5% by mass. , xanthan gum, toothpaste composition, characterized in that one selected from hydroxyethyl cell row scan and propylene glycol alginate or more polymer compounds comprising a 0.8-1.6% by weight.
[2]
As component supplying potassium ions in the composition, potassium nitrate, potassium chloride, one or containing two or more water-soluble potassium salt [1] toothpaste composition according selected from dipotassium glycyrrhizinate and acesulfame potassium.
[3]
The toothpaste composition according to [1] or [2], wherein the sodium ion concentration in the composition is 0.1 to 0.2% by mass.
[ 4 ]
Further, containing 0.01 to 0.5 wt% of sucralose and / or aspartame [1], [2] or [3] toothpaste composition.
[ 5 ]
Additionally, toothpaste composition according to any one of aluminum lactate containing 0.5 to 5 wt% [1] to [4].

  According to the dentifrice composition of the present invention, potassium ions act effectively, and pain caused by hypersensitivity of dentin can be effectively suppressed. In addition, it is possible to provide a preparation that can provide good foaming, can suppress disgusting taste, and has low spinnability that can reduce the ability to collect into a toothbrush.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention has an appropriate ratio of potassium ion to sodium ion and potassium ion concentration in the composition, and includes amphoteric surfactant, xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, and propylene glycol alginate. It is characterized by containing an appropriate amount of the selected polymer compound.

  In the dentifrice composition of this invention, the component (A) which supplies a potassium ion is included in a composition. This component is a basic component that suppresses pain caused by hypersensitivity to dentin, and the proportion of potassium ions supplied by such components is greater than a specific value with respect to sodium ions contained in the composition, and the potassium ion concentration It is important for the effects of the present invention to be within an appropriate range.

The component (A) for supplying potassium ions is not particularly limited as long as it can be used in the oral cavity, and various water-soluble potassium salts can be used. For example, potassium nitrate, potassium chloride, potassium hydroxide, potassium fluoride, potassium bromide, potassium phosphate, potassium carbonate, potassium malate, potassium citrate, potassium tartrate, potassium metaphosphate, potassium pyrophosphate, dipotassium glycyrrhizinate, Acesulfame potassium etc. are mentioned, These 1 type (s) or 2 or more types can be used. In particular, potassium nitrate, potassium chloride, dipotassium glycyrrhizinate, and acesulfame potassium are preferable. Potassium nitrate and potassium chloride are preferable because they have less unpleasant taste, and dipotassium glycyrrhizinate and acesulfame potassium are more preferable because sweet taste can suppress unpleasant taste.
In addition, when two or more components that supply potassium ions are used in combination, the combined use of potassium nitrate and / or potassium chloride and dipotassium glycyrrhizinate and / or acesulfame potassium may cause pain caused by hypersensitivity of dentin. In addition to being able to suppress, it is more preferable because it can effectively suppress disgust and improve the feeling of use.

A commercially available thing can be used as a component (A) which supplies a potassium ion.
For example, potassium nitrate (made by Otsuka Chemical Co., Ltd.), potassium chloride (made by Otsuka Chemical Co., Ltd.), etc. are mentioned.
In addition, acesulfame potassium is 6-methyl-1,2,3-oxathiazin-4 (3H) -one-2,2-dioxide, which is one of artificial sweeteners, and sucrose (sucrose). 200 times the sweetness. For example, commercially available acesulfame potassium (manufactured by Neutrinova Japan Co., Ltd.) can be used.
Dipotassium glycyrrhizinate is a component contained in Chinese medicine licorice, has an anti-inflammatory action and has a characteristic sweetness due to glycyrrhizic acid. For example, commercially available products such as dipotassium glycyrrhizinate (manufactured by Alps Pharmaceutical Co., Ltd.) can be used.

  The potassium ion concentration in the composition is 1.7 to 3%, preferably 1.9 to 3.0%, more preferably 1.9 to 2.5%. The potassium ion supply component is blended in such a concentration range, and if the potassium ion concentration is less than 1.7%, the effect of suppressing the sore pain may not be sufficiently obtained. If it exceeds 3%, taste may become strong and the feeling of use may worsen.

  In this invention, the ratio of the potassium ion with respect to the sodium ion in a composition is 11 times or more as mass ratio, Preferably it is 12-25, More preferably, it is 13-20. If the ratio is less than 11, the effect of suppressing the soreness of teeth is not sufficiently exhibited, and the object of the present invention cannot be achieved.

In the dentifrice composition, sodium ions are contained in the components that are usually blended. In this invention, the component which supplies sodium ion in a composition is not restrict | limited in particular, The sodium ion containing component generally mix | blended is mentioned. Sodium ion is usually present as an inorganic or organic component counter ion or the like blended in the composition.
Examples of the component for supplying sodium ion include 8 to 18 carbon atoms such as sodium lauryl sulfate, in particular 12 to 14 alkyl sulfate sodium, acyl sarcosine sodium such as lauroyl sarcosine sodium, lauroyl taurine sodium such as lauroyl methyl taurine sodium, Anionic surfactants such as sodium α-olefin sulfonate, anionic binders such as sodium polyacrylate, sodium alginate, sodium carboxymethylcellulose, sodium chloride, sodium fluoride, sodium monofluorophosphate, sodium tripolyphosphate, Sodium pyrophosphate, copper chlorophyllin sodium, sodium citrate, sodium phosphate, sodium saccharin, sodium benzoate, etc. And the like. These have sodium ions as counter ions.
In addition, some amphoteric surfactants to be described later may be components that supply sodium ions, such as N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium, N-lauroyl-N-carboxymethyl. -N-hydroxyethyl ethylenediamine sodium etc. are mentioned.

  The sodium ion concentration in the composition is preferably from 0.1 to 0.2%, more preferably from 0.12 to 0.18% from the viewpoint of effect expression. If it exceeds 0.2%, the effect of suppressing soreness may not be sufficiently obtained. On the other hand, if it is less than 0.1%, foaming may be inferior or spinnability may be increased. It should be noted that adjusting the content of a component serving as a supply source of sodium ions is a compositional feature of the present invention, but causes problems such as foaming and spinnability. According to the present invention, such problems of foaming and spinnability are also solved, and excellent foaming and spinnability can be ensured even when the sodium ion concentration is lower than a general dentifrice composition.

  Moreover, the component mix | blended with a dentifrice composition may contain a sodium ion in a formulation component in the manufacture process, for example, the amphoteric surfactant mentioned later may also contain a sodium ion in a manufacture process. In the present invention, the sodium ion concentration in the composition is preferably such that the total amount including the sodium ions contained in the components in the production process and in the composition is in the above range.

  In the present invention, the amphoteric surfactant (B) is not particularly limited, and known ones can be used. Particularly, betaine-based ones are suitable, and examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, alkyldimethylaminoacetic acid betaine, and fatty acid amidopropyl betaine. Among these, from the viewpoint of foaming, those having an alkyl chain length of 8 to 16, particularly 12 to 14 are preferred.

Examples of 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine include N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium, N-lauroyl-N-carboxymethyl-N- Examples include sodium hydroxyethylethylenediamine.
Specific examples include 2-coconut oil alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium aqueous solution sold by Lion Corporation under the trade name Enadicol C-40H.

As the alkyldimethylaminoacetic acid betaine, for example, an aqueous solution of lauryldimethylaminoacetic acid betaine sold by Nikko Chemicals Co., Ltd. under the trade name NIKKOL AM-301 is used.
Examples of the fatty acid amidopropyl betaine include coconut oil fatty acid amidopropyl betaine aqueous solution sold by Goldschmidt as trade names TEGO BetainCK, TEGO BetaF50, and TEGO Betatain ZF, and lauric acid sold by Kao Corporation under the trade name Amphital 20AB. Amidopropyl betaine (30% aqueous solution product) or the like is used, but in any case, it is not limited to the above.

Amphoteric surfactant (B) may be used individually by 1 type, or may use 2 or more types together. The blending amount is preferably 0.5 to 1.5% of the total composition, and more preferably 0.7 to 1.2%. If the blending amount is less than 0.5%, good foaming may not be ensured at the time of brushing, and if it exceeds 1.5%, taste may be increased and usability may be deteriorated.
In addition, amphoteric surfactant (for example, about 30-40% aqueous solution) often contains about 5% sodium chloride in the amphoteric surfactant solution because sodium chloride is by-produced during the production process. Therefore, it is desirable to adjust the blending amount of the amphoteric surfactant (B) within a range where the ratio of potassium ions to sodium ions in the composition is appropriate.

  In the present invention, a polymer compound (C) selected from xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, and propylene glycol alginate is blended, and one of these is used alone or two in terms of effect. The above can be used in combination. Among the above polymer compounds, xanthan gum, hydroxyethyl cellulose, and propylene glycol alginate are particularly preferable because of their high foaming improvement effect, and xanthan gum having a good feeling in use is particularly preferable. These are known compounds as binders, but are effective in improving foaming in the present invention.

  As the xanthan gum, those having a viscosity (25 ° C.) of 1,000 to 2,000 mPa · s when the viscosity is measured by the method defined in the section of the pharmaceutical additive standard 2003 “xanthan gum” are preferable. As such xanthan gum, commercially available products such as Novazan manufactured by ADM Far East Co., Ltd., Monato Gum DA manufactured by CP Kerco Co., Ltd., Kelzan T, Keldent, Echo Gum manufactured by Dainippon Pharmaceutical Co., Ltd., etc. can be used.

  Hydroxyethylcellulose, hydroxypropylmethylcellulose, and methylcellulose are nonionic and water-soluble cellulose polymer compounds, and among these, hydroxyethylcellulose is particularly preferred in terms of foaming.

Hydroxyethyl cellulose having a viscosity in a 1% aqueous solution of 50 to 10,000 mPa · s (B-type viscometer, rotor No. 4, 30 rpm, 20 ° C., measured value after 2 minutes, the same applies hereinafter) is preferable. Can be used for In particular, those having a moldability of 500 mPa · s or more are preferred, and those having a solubility of 8,000 mPa · s or less are preferred.
Specific examples of hydroxyethyl cellulose include those sold by Daicel Chemical Industries, Ltd. under product names such as SE600, SE850, and SE900.

As hydroxypropylmethylcellulose, those having a viscosity of 100 to 12,000 mPa · s (20 ° C., 2% aqueous solution, measured by the Japanese Pharmacopoeia rotational viscometer method, the same shall apply hereinafter) are preferable. In particular, those having a moldability of 1,000 mPa · s or more are preferred, and those having a solubility of 10,000 mPa · s or less are preferred.
As such hydroxypropyl methylcellulose, those sold by Shin-Etsu Chemical Co., Ltd. under the product names such as METOLOSE 60SH 4000, METOLOSE 60SH 10000, and METOLOSE 65SH 4000 can be used.

As methylcellulose, those having a viscosity of 100 to 10,000 mPa · s (20 ° C., 2% aqueous solution, measured value by rotational viscosity method of the Japanese Pharmacopoeia, the same shall apply hereinafter) can be preferably used. In particular, those having a moldability of 1,000 mPa · s or more are preferred, and those having solubility of 5,000 mPa · s or less are preferred.
As such methylcellulose, those sold by Shin-Etsu Chemical Co., Ltd. under the product names such as METOLOSE SM 1500 and METOLOSE SM 4000 can be used.

  Propylene glycol ester of alginic acid is obtained by esterifying the carboxyl group of alginic acid with propylene oxide. Depending on the application, various degrees of polymerization, that is, various molecular weights, various intramolecular β-D-mannuronic acid / α-L-guluronic acid. Quantitative ratios (M / G ratio, molar ratio, the same applies hereinafter) and various esterification degrees can be used. Particularly preferred is a propylene glycol alginate having an M / G ratio of more than 1. The upper limit is 2 or less. Those exceeding 2 are not commercially available and are difficult to obtain.

  The esterification degree of the carboxyl group is preferably 40% or more, more preferably 70 to 95%.

The propylene glycol alginate ester preferably has a 1% aqueous solution having a viscosity at 20 ° C. of 10 to 1,300 mPa · s, particularly 10 to 200 mPa · s. In addition, the viscosity measurement was performed on condition of the following conditions by the magnitude | size of the viscosity of 1% aqueous solution measured for 1 minute using BL type viscometer by Tokyo Keiki Co., Ltd. (hereinafter the same).
In the case of 10 to 80 mPa · s (rotor: No. 1, rotation speed: 60 rpm)
In the case of more than 80 mPa · s and 160 mPa · s or less (rotor: No. 1, rotation speed: 30 rpm)
When it exceeds 160 mPa · s and is 400 mPa · s or less (rotor: No. 2, rotation speed: 60 rpm)
In case of 400 mPa · s to 800 mPa · s or less (rotor: No. 2, rotation speed: 30 rpm)
In the case of over 800 mPa · s and 1,600 mPa · s or less (rotor: No. 3, rotation speed: 60 rpm)

  Specific examples of the propylene glycol alginate include the trade names Kimiloid BF, Kimiloid HV, Kimiloid LV, Kimiloid LLV, Kimiloid MV, Kimiloid NLS-K, kelp acid 503, kelp acid 542, and food manufactured by Kimika Co., Ltd. Chemifa brand names Duck Lloyd LF, Duck Lloyd PF, and the like can be mentioned, and these commercially available products can be used.

  The content of the polymer compound (C) is preferably 0.5 to 2% of the entire composition, more preferably 0.8 to 2.0%, and still more preferably 0.8 to 1.6%. If it is less than 0.5%, foaming of the dentifrice composition is lowered, and the usability may be deteriorated. If it exceeds 2%, the spinnability of the preparation becomes strong, and when it is collected in a toothbrush, the kneading may become worse.

  In the present invention, blending these polymer compounds (C) in combination with the amphoteric surfactant (B) is effective in improving foaming. The reason why foaming is good is not clear, but xanthan gum with less anionic groups compared to anionic binders such as sodium polyacrylate and sodium alginate, and the above cellulose derivatives and alginic acid which are nonionic binders In propylene glycol ester, it is estimated that the water retention of the hydroxyl group in the sugar skeleton is increased, and foaming is improved by stabilizing the foam film formed by the amphoteric surfactant.

In the present invention, as described above, it is possible to further suppress disgusting by including dipotassium glycyrrhizinate and acesulfame potassium. In this case, dipotassium glycyrrhizinate and acesulfame potassium containing a potassium salt in the compound are the essence of the present invention. It is advantageous in that the ratio of potassium ion to sodium ion is 11 or more. However, in the present invention, when sucralose and / or aspartame (D) is further added, it is preferable because taste can be further suppressed. is there.
Sucralose is one of artificial sweeteners, has a sweetness about 600 times that of sucrose (sucrose), and exhibits excellent acid resistance and heat resistance in an aqueous solution. Aspartame is also an artificial sweetener and has a sweetness 100 to 200 times that of sucrose. Examples include aspartame (manufactured by Ajinomoto Co., Inc.), sucralose (manufactured by Saneigen FFI Co., Ltd.), and the like, and these commercially available products can be used.

  (D) When mix | blending sucralose and / or aspartame of a component, 0.01-0.5% of the whole composition is preferable, More preferably, it is 0.1-0.3%. If it is less than 0.01%, taste may not be sufficiently suppressed. If it exceeds 0.5%, the sweetness may become too strong.

Many commercially available dentifrice compositions contain saccharin sodium, which is an artificial sweetener. However, although saccharin sodium has a sweetness 500 times that of sucrose (sucrose), the unpleasant taste related to the present invention is not necessarily suppressed by simply increasing the amount of saccharin sodium.
In the present invention, it is not clear why the taste can be suppressed by blending the above-mentioned dipotassium glycyrrhizinate, acesulfame potassium, sucralose, aspartame, but not only the sweetness level of these components but also the effect on the taste buds on the tongue It is speculated that there is a difference between the two.

Furthermore, in this invention, it is preferable to contain aluminum lactate (E). By blending aluminum lactate, the pain caused by hypersensitivity to dentin is further suppressed.
Aluminum lactate is an active ingredient for preventing or treating dentin hypersensitivity, and a commercially available product can be used. For example, aluminum lactate is commercially available from Musashino Chemical Co., Ltd.

  (E) When mix | blending the component aluminum lactate, 0.5 to 5% of the whole composition is preferable, More preferably, it is 1.5 to 2.5%. If it is less than 0.5%, the pain caused by hypersensitivity to dentine may be suppressed, and if it exceeds 5%, the taste may be strong and the usability may be deteriorated.

  A technique for suppressing pain caused by hypersensitivity of dentin by using potassium nitrate and aluminum lactate having different action mechanisms is already known. However, aluminum lactate is known to have a low immediate effect on pain due to its action mechanism, whereas in the present invention, adding aluminum lactate increases the effect of suppressing sore pain immediately after brushing. It is presumed that there is some synergistic effect.

The dentifrice composition of the present invention is suitably prepared as a dentifrice such as a toothpaste, a liquid dentifrice, a liquid dentifrice, and a toothpaste, especially a toothpaste. Depending on the dosage form, in addition to the above components, other known components that are usually blended in dentifrice compositions, such as abrasives, surfactants, binders, thickeners, medicinal ingredients, sweeteners, Colorants, preservatives, pH adjusters, fragrances, and the like may be blended as necessary within a range that does not impair the effects of the present invention.
In addition, it is preferable to mix | blend the component in which sodium ion is contained in the range from which the ratio of potassium ion with respect to sodium ion becomes more than the said appropriate value.

  Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrous. , Calcium pyrophosphate, tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate, aluminum hydroxide, alumina, titanium dioxide, zeolite, hydroxyapatite, fluoroapatite, calcium deficient apatite, polymethylmethacrylate, synthetic resin abrasive, etc. Is mentioned. Among these, a silica-based abrasive is preferable from the viewpoint of foaming. The blending amount of these abrasives is preferably 5 to 50% of the total composition. In particular, the silica-based abrasive is preferably 15 to 30%.

As the surfactant, in addition to the amphoteric surfactant (C), a nonionic surfactant may be blended. Nonionic surface activity such as polyoxyethylene alkyl ether, alkyl glycoside, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, fatty acid polyglyceryl, polyoxyethylene hydrogenated castor oil Agents.
When these surfactants are blended, the blending amount is preferably 5% or less, particularly preferably 0 to 2%.

  Examples of the thickener include sugar alcohols such as sorbitol, xylitol, maltitol, and erythritol, and polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, and polypropylene glycol. The blending amount of the thickener is usually 10 to 50%, particularly 15 to 40%.

  As the binder, xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, propylene glycol alginate, and anionic binders described as components for supplying sodium ions may be blended. For example, synthetic binders such as carrageenan, inorganic binders such as gelling silica, bee gum, and laponite can be blended within a range that does not impair the effects of the present invention. The blending amount of these binders is preferably 0 to 1.0%.

  As the medicinal component (active component), in addition to the compounds described as the component supplying sodium ion, for example, fluoride such as stannous fluoride and strontium fluoride, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine , Bactericidal substances such as triclosan, isopropylmethylphenol, sorbate, hinokitiol, and azulene sulfonate, glucanase enzymes such as dextranase and mutanase, proteases such as protease and lysozyme, tranexamic acid, epsilon aminocaproic acid, allantoin, Anti-inflammatory substances such as glycyrrhizic acid and glycyrrhetinic acid; inorganic salts such as zinc chloride, zinc citrate and strontium chloride; chelating compounds such as zeolite, chlorophyll and glycerophosphate; Rubin acid, various vitamins such as tocopherol acetate, pyridoxine, Japanese angelica root soft extract, Phellodendron bark extract, camomile, clove, rosemary, scutellaria root, and a natural extract of safflower like. The amount of these active ingredients is an effective amount as long as the effects of the present invention are not hindered.

  As the sweetener, for example, stevioside, neohesperidyl dihydrochalcone, perilartin, p-methoxycinnamic aldehyde and the like can be blended.

As coloring agents, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3, mica titanium, titanium oxide and the like.
Examples of the preservative include paraoxybenzoic acid esters.

Examples of the pH adjuster include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, glycerophosphoric acid, and various salts thereof, and can be appropriately selected and used according to a desired pH.
It is preferable that the dentifrice composition of this invention is adjusted to pH 6-10, especially 7-9.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, and fragrances processed by these natural fragrances (total reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and , Menthol, carvone, anethole, cineol, salicylic acid , Cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octyl Acetaldehyde, citral, pregon, calbeetoacetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl Alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate Toothpaste composition such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The well-known fragrance | flavor raw material used for a thing can be used, It is not limited to the fragrance | flavor of an Example. Moreover, although a compounding quantity is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

The material in particular of a container is not restrict | limited, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used. For example, a laminate tube having a diameter of 26 mm and a mouth inner diameter of 8 to 12 mm (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30 from the outermost layer) can be preferably used. The above abbreviations are as follows, and the number at the end indicates the thickness (μm).
LDPE: Low density polyethylene White LDPE: White low density polyethylene LLDPE: Linear low density polyethylene AL: Aluminum PET: Polyethylene terephthalate EMAA: Copolymer resin of ethylene / methacrylic acid

EXAMPLES Hereinafter, although an Example , a reference example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%. Moreover, about the component whose form is aqueous solution, all showed the compounding quantity of pure content also including the table | surface. Each viscosity is a value measured by the same method as described above.

[Examples , reference examples , comparative examples]
Toothpaste compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by the following method and filled into a laminate tube having a diameter of 26 mm and a mouth inner diameter of 8 mm. The obtained dentifrice composition was evaluated by the following method, and the results are shown in Tables 1 to 3.

Preparation of test dentifrice composition:
After dissolving water-soluble substances such as potassium nitrate, saccharin sodium, and sodium fluoride in purified water and adding thickening anhydrous silicic acid and sorbite, polymer such as xanthan gum is separately added to propylene glycol. The liquid in which the compound was dispersed was added and stirred. Thereafter, a polishing agent such as fragrance, silicic anhydride, and an amphoteric surfactant were sequentially added, and the mixture was further stirred under reduced pressure (5.3 kPa) to obtain a dentifrice composition. A unimixer (FM-SR-25, manufactured by POWEX CORPORATION) was used for the production.

The detail of each component used for preparation of these dentifrice compositions is as follows.
Potassium nitrate (Otsuka Pharmaceutical Co., Ltd.)
Potassium chloride (made by Yoneyama Chemical Co., Ltd.)
Acesulfame potassium (manufactured by Neutrinova Japan KK)
Dipotassium glycyrrhizinate (manufactured by Alps Pharmaceutical Co., Ltd.)
Coconut oil fatty acid amidopropyl betaine (30% aqueous solution of palm oil fatty acid amidopropyl betaine, TEGO BETAIN CK, manufactured by Goldschmidt)
Lauric acid amidopropyl betaine (30% aqueous solution product of lauric acid amidopropyl betaine, Amphital 20AB, manufactured by Kao Corporation)
N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium (40% aqueous solution (solid content) of N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium, Enadicol C- 40H, manufactured by Lion Corporation)
Xanthan gum (monate gum DA (viscosity 1,470 mPa · s), manufactured by CP Kerco), hydroxyethyl cellulose (SE900, 1% aqueous solution viscosity 5,000 mPa · s, manufactured by Daicel Chemical Industries), propylene glycol alginate (Made by Kimika Co., Ltd., trade name Kimiloid BF, M / G ratio 1.3, esterification degree 80%)
Aspartame (manufactured by Ajinomoto Co., Inc.), sucralose (manufactured by Saneigen FFI Co., Ltd.), aluminum lactate (manufactured by Musashino Chemical Co., Ltd.)
Other ingredients such as sodium fluoride, sodium saccharin, sodium polyacrylate, sodium alginate, sodium carboxymethylcellulose (RS1.0), sodium lauryl sulfate, sodium dihydrogen phosphate, sodium hydroxide, propylene glycol, sorbit ( 70% aqueous solution product), silicic anhydride, thickening silicic anhydride, and water were those conforming to the quasi-drug raw material standard 2006.

  The container used in the following evaluation was a laminated tube (Dai Nippon Printing Co., Ltd.) having a diameter of 26 mm and a mouth inner diameter of 8 mm, and the layer structure was LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / from the outermost layer. AL10 / EMAA30 / LDPE20 / LLDPE30, and thickness is 257 μm. The abbreviations are as described above, and the numerical values indicate the thickness (μm) of each layer.

Evaluation method:
(1) The effect of suppressing pain in cold water after brushing teeth (inhibition of hypersensitivity)
Ten panelists with hypersensitivity that the teeth squeeze when cold water is in their mouths push the test dentifrice composition filled in the laminate tube 1 cm onto the toothbrush, brush the teeth for 2 minutes in the same way as usual, then cool water (10 The pain that occurred when the mouth was included in the mouth was evaluated according to the following score. Judgment was made from the average score of 10 people according to the following evaluation criteria.
(Score)
5 points: Even if cold water is included in the mouth, teeth do not bleed at all. 4 points: Even if cold water is included in the mouth, teeth do not bleed. 3 points: If cold water is included in the mouth, teeth slightly squeeze, but there is no problem. If cold water is contained in the mouth, the teeth rub and hurt 1 point: If cold water is contained in the mouth, the teeth will bruise and hurt (Evaluation criteria)
◎: Average score of 10 people is 4.0 points or more ○: Average score of 10 people is 3.0 points or more and less than 4.0 points △: Average score of 10 people is 2.0 points or more and less than 3.0 points × : Average score of 10 people is less than 2.0

(2) Evaluation of tastelessness It evaluated by the sensory test using ten expert panelists. About 1.5 cm of the test dentifrice composition was placed on a toothbrush and used in a normal brushing method. The tasteless taste felt during brushing was evaluated according to the following rating. An average value of the evaluation results of 10 people was obtained, and those for which evaluations of ◎ and ○ were ensured on the basis of the following criteria were judged to be dentifrice compositions without taste.
(Score)
4 points: no disgusting 3 points: little disgusting 2 points: somewhat disgusting 1 point: disgusting (Evaluation criteria)
◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

(3) Evaluation of foaming at the time of tooth brushing It evaluated by the sensory test using ten expert panelists. About 1.5 cm of a test dentifrice composition was placed on a toothbrush and used in a normal brushing method, and foaming in the oral cavity during brushing was evaluated according to the following rating. An average value of the evaluation results of 10 people was obtained, and those for which evaluations of ◎ and ◯ were ensured according to the following criteria were judged to be a dentifrice composition with satisfactory foaming.
(Score)
4 points: Sufficient amount of foaming and excellent usability 3 points: Moderate amount of foaming and satisfactory usability 2 points: Little amount of foaming and slightly inferior to usability 1 point: Almost no foaming Feeling bad (Evaluation criteria)
◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

(4) Evaluation of spinnability (goodness of kneading) The test dentifrice composition filled in a laminate tube having an inner diameter of 8 mm is extruded and about a toothbrush (made by Lion Corporation, Clinica Habrush 4 row head, medium) 1g was loaded, and the spinnability of the dentifrice composition when the tube and the toothbrush were pulled upward was tested. The stringiness refers to the property that the dentifrice composition stretches as if it is pushed out from a container such as a tube, and is an index of the goodness of the dentifrice composition, and its length is measured. The evaluation was based on the following evaluation criteria. ◎ and ○ were judged to have no problem with the spinnability.
(Evaluation criteria)
A: The length extended in a thread form is less than 0.5 cm, and the kneading is good. The stretched length is 1 cm or more, and there is a problem in use.

*: Palm oil fatty acid amidopropyl betaine, lauric acid amidopropyl betaine, and N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium are each 5.2 in the raw material aqueous solution of the blending raw material as follows. %, 5.3%, and 9.0% NaCl, and the amount of NaCl (%) was determined from the blended amount of these amphoteric surfactants and indicated in parentheses in the table (hereinafter the same) .)
NaCl concentration in 30% coconut oil fatty acid amidopropyl betaine solution 5.2%
NaCl concentration in 30% amidopropyl betaine solution of lauric acid 5.3%
NaCl concentration in 40% N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium solution 9.0%
**: The value in terms of pure content is shown (the same applies hereinafter).

  From Tables 1 to 3, the dentifrice composition of the present invention can suppress pain caused by hypersensitivity of dentin due to the effective action of potassium ions, and can also provide good foaming and suppresses taste. It was found that there was no problem with the spinnability, which would reduce the ability to collect into a toothbrush, and the kneading was good. In addition, it can be seen that the addition of dipotassium glycyrrhizinate, acesulfame potassium, sucralose, or aspartame can further suppress taste tasting, and the addition of aluminum lactate improves the pain-suppressing effect of dentine hypersensitivity. It was.

Claims (5)

The ratio of potassium ions to sodium ions in the composition is 11 or more as a mass ratio, the potassium ion concentration is 1.7 to 3% by mass, and the betaine amphoteric surfactant is 0.7 to 1.5% by mass. , xanthan gum, toothpaste composition, characterized in that one selected from hydroxyethyl cell row scan and propylene glycol alginate or more polymer compounds comprising a 0.8-1.6% by weight. As component supplying potassium ions in the composition, potassium nitrate, potassium chloride, one or toothpaste composition according to claim 1 containing two or more water-soluble potassium salt selected from dipotassium glycyrrhizinate and acesulfame potassium. The toothpaste composition according to claim 1 or 2, wherein the sodium ion concentration in the composition is 0.1 to 0.2 mass%. Furthermore, according to claim 1, 2 or 3 toothpaste composition according containing 0.01 to 0.5 wt% of sucralose and / or aspartame. Additionally, toothpaste composition of any one of claims 1-4 containing aluminum lactate 0.5-5% by weight.