JP2011105682A - Toothpaste composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a toothpaste composition while having a strong astringent real feeling, having an easiness of putting it well on a toothbrush, having less threading property and excellent in preservation stability as almost not having liquid separation or the deterioration of paste surface after a long term preservation, and further the tooth paste composition having a good taste by suppressing a bitter taste. <P>SOLUTION: This toothpaste composition includes (A) 0.1 to 3 mass% copper compound and/or zinc compound, (B) 0.1 to 3 mass% xanthan gum and/or hydroxyalkylcellulose, and (C) 0.1 to 4 mass% powdery cellulose, and having 0.1 to 15 mass ratio of (B)/(A) and 0.1 to 15 mass ratio (C)/(B). Further, (D) 0.1 to 1 mass% sweetener is blended to the toothpaste composition. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention provides a dentifrice that has excellent converging feeling, has good ease of placement on a toothbrush, has little stringiness, has almost no liquid separation or deterioration of pasted skin over time, and has excellent storage stability. Relates to the composition.

  In general, adding a compound such as copper gluconate, copper citrate, copper sulfate, copper chlorophyllin sodium, or zinc compounds such as zinc chloride, zinc oxide, zinc carbonate, etc. to a dentifrice composition will give a sense of convergence. It has been known. From the viewpoint of imparting a sense of realism in line with the flavor and function imparted to the dentifrice composition, it is possible to impart a converging realism suitable for the flavor and function by containing the above compound.

However, if a copper compound or zinc compound is added to give the dentifrice composition sufficient convergence, it is inferior in ease of being placed on the toothbrush, water retention is lost over time, and liquid separation becomes easier. It turned out that the problem that skin deteriorates arises.
Furthermore, if a binder or the like that is not easily affected by the copper compound or zinc compound is used, the ease of placing on the toothbrush, liquid separation after long-term storage, and deterioration of the skin can be improved to some extent, but this is not sufficient. In some cases, it was also found that a new problem arises that the spinnability of the dentifrice composition becomes high.

  For this reason, it has a satisfactory converging feeling derived from copper compounds and zinc compounds, good spinnability, good ease of placement on toothbrushes, almost no liquid separation after long-term storage and no deterioration of paste skin, dentifrice composition Although development of products is desired, it has been difficult to satisfy all of them with the conventional technology.

  Patent Document 1 describes zinc oxide, xanthan gum, and cellulose powder as components that can be incorporated into cosmetics or skin external preparations using diester as an oil, and Patent Document 2 describes substances suitable for placement or application to the skin. In Examples 39, 40, and 42, a hydrodispersion containing zinc oxide and xanthan gum is described, and in Patent Document 3, a composition containing copper gluconate and xanthan gum as a bad breath prevention composition as a patch is described. However, Patent Documents 1 to 3 do not solve the above-described problems and do not show a composition in which these components are used in a specific amount and a specific ratio.

JP 2005-206573 A JP 2006-524520 A JP 2006-182705 A

  The present invention has been made in view of the above circumstances, solves the above-mentioned various problems, has a satisfactory convergence, and is easy to put on a toothbrush, has little spinnability, and is liquid after long-term storage. An object of the present invention is to provide a dentifrice composition having almost no separation and deterioration of the skin, and excellent storage stability.

  As a result of intensive studies to achieve the above object, the present inventor has (A) 0.1 to 3% by mass of a copper compound and / or zinc compound, and (B) 0.1% of xanthan gum and / or hydroxyalkyl cellulose. ~ 3% by mass, (C) 0.1 to 4% by mass of powdered cellulose, and (B) / (A) is a mass ratio of 0.1 to 15, and (C) / (B) is a mass ratio. By setting it to 0.1 to 15, it has a surprisingly satisfactory converging feeling, is easy to put on a toothbrush, has reduced stringiness, and deteriorates liquid separation and skin after long-term storage. Copper compound and / or zinc compound because (D) 0.1-1% by mass of sweetener and (D) / (A) mass ratio is 0.1-4 That the bitterness derived from this can be reduced, the sweetness is moderate, and the feeling of use can be improved. It came to be.

  That is, the present inventor is less susceptible to the influence of the copper compound or the zinc compound when xanthan gum and / or hydroxyalkyl cellulose is selected and used as the binder when the copper compound or the zinc compound is blended in the dentifrice composition. Although it is possible to improve ease of placement on toothbrushes, liquid separation after long-term storage, and prevention of deterioration of condensed skin, it has been found that a new problem arises that the dentifrice composition has high spinnability. Further study was conducted. As a result, as is clear from the examples described later, by using the above components (A) to (C) together in specific amounts and blending ratios, satisfactory content suitable for flavors and functions that could not be solved by the prior art A dentifrice composition that satisfies all of liquid separation after long-term storage, deterioration of the condensed skin, spinnability, ease of placement on a toothbrush, and can also improve taste by suppressing bitterness while giving a sense of convergence It has been found that it can be.

Accordingly, the present invention provides the following dentifrice composition.
Claim 1:
(A) 0.1-3 mass% of copper compound and / or zinc compound,
(B) 0.1 to 3% by mass of xanthan gum and / or hydroxyalkyl cellulose;
(C) 0.1-4 mass% of powdered cellulose
Dentifrice composition characterized by containing (B) / (A) 0.1-15 and (C) / (B) 0.1-15 by mass ratio.
Claim 2:
The dentifrice composition according to claim 1, wherein the copper compound and / or the zinc compound is at least one selected from copper gluconate, copper citrate, zinc oxide, zinc chloride, zinc carbonate, and zinc citrate.
Claim 3:
Furthermore, (D) 0.1-1 mass% of sweeteners are contained, The dentifrice composition of Claim 1 or 2 characterized by the above-mentioned.
Claim 4:
The dentifrice composition according to claim 3, wherein the mass ratio of (D) / (A) is 0.1-4.

  The dentifrice composition of the present invention is satisfactory in ease of placing on a toothbrush while having a satisfactory sense of convergence, hardly undergoes liquid separation after long-term storage and deterioration of the skin, and has little stringiness. Furthermore, the feeling of use can also be improved by reducing the bitterness derived from the copper compound and / or the zinc compound.

  The dentifrice composition of the present invention contains (A) a copper compound and / or a zinc compound, (B) xanthan gum and / or hydroxyalkyl cellulose, and (C) powdered cellulose, more preferably (D) a sweetener. Blended.

(A) A copper compound and / or a zinc compound are components blended for the purpose of imparting a sense of convergence. Specific examples include copper compounds such as copper gluconate, copper citrate, copper sulfate, and copper chlorophyllin sodium, and zinc compounds such as zinc chloride, zinc oxide, zinc carbonate, and zinc citrate. Of these, copper gluconate, copper citrate, zinc oxide, zinc chloride, zinc carbonate, and zinc citrate are preferred from the standpoint of convergence. Moreover, a copper compound and a zinc compound can also be used in the form of a granulated product with water-insoluble powders such as calcium carbonate, dicalcium phosphate, and tricalcium phosphate.
(A) As a component, it can be used individually by combining 1 type chosen from a copper compound and a zinc compound, or 2 or more types, Even if it uses a copper compound or a zinc compound, it combines a copper compound and a zinc compound. Two or more kinds may be blended.

  A commercially available thing can be used as a copper compound and a zinc compound, for example, Kanto Chemical Co., Ltd. copper D-gluconate (II), zinc oxide, etc. are mentioned.

  The compounding quantity of a copper compound and / or a zinc compound is 0.1-3 mass% of the whole composition, Preferably it is 0.3-2 mass%. If the blending amount is less than 0.1% by mass, it is not possible to give a feeling of convergence when using a dentifrice, and if it exceeds 3% by mass, it is inferior in ease of placing on a toothbrush, liquid separation after storage, deterioration of the skin Occurs.

The component (B) is xanthan gum and / or hydroxyalkyl cellulose.
The xanthan gum may be any as long as it is usually used in a dentifrice composition, but a 0.5% by mass aqueous solution (25 ° C.) measured with a B-type viscometer, particularly a BH-type rotational viscometer. The viscosity is preferably 30 to 200 Pa · s, more preferably 100 to 200 Pa · s.
As such xanthan gum, commercially available products such as Novazan manufactured by ADM Far East Co., Ltd., Monato Gum DA manufactured by Kelco Co., Kelzan T, Keldent, Echo Gum manufactured by Dainippon Pharmaceutical Co., Ltd., and the like can be used.

  Hydroxyalkyl cellulose is a nonionic and water-soluble cellulose polymer compound, and examples thereof include hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl ethyl cellulose, and the like, and hydroxyethyl cellulose is particularly preferable.

  Any hydroxyalkyl cellulose may be used as long as it is usually used in a dentifrice composition. However, from the viewpoint of increasing the viscosity of the composition, measurement with a B-type viscometer, particularly a BH-type rotational viscometer (rotor No. 7, rotation speed 20 rpm, rotation time 3 minutes) 1% by weight aqueous solution (25 ° C.) having a viscosity of 30 to 300 Pa · s, particularly 100 to 250 Pa · s is preferable. Hydroxyalkyl cellulose is commercially available. Specifically, as hydroxyethyl cellulose, HEC Daicel manufactured by Daicel Chemical Industries, Netrosol manufactured by Hercules Co., Ltd., Sanhec manufactured by Sanki Co., Ltd., etc. Can be mentioned.

  As the component (B), xanthan gum or hydroxyalkyl cellulose may be used, xanthan gum and hydroxyalkyl cellulose may be used in combination, or one kind may be used alone, or two or more kinds may be used in combination. The blending amount is 0.1 to 3% by mass, preferably 0.3 to 2% by mass, based on the total composition, from the standpoint of liquid separation after storage, ease of placement on a toothbrush, and spinnability. If the blending amount is less than 0.1% by mass, liquid separation after storage occurs, and it becomes difficult to place on a toothbrush. If it exceeds 3% by mass, the spinnability and ease of placing on a toothbrush are poor.

  The ratio of the component (B) to the component (A) ((B) / (A)) is 0.1 in terms of mass ratio from the standpoints of liquid separation after storage, paste skin, ease of placement on a toothbrush and spinnability. ~ 15, preferably 0.2-6. If (B) / (A) is less than 0.1, liquid separation or deterioration of the skin will occur after storage, and it will be difficult to place it on the toothbrush, and if it exceeds 15, it will be inferior in stringiness and ease of placement on the toothbrush.

  (C) Powdered cellulose is a water-insoluble cellulose polymer compound, and is powdery crystalline cellulose. The powdered cellulose is blended for the purpose of preventing deterioration of the spinnability of the dentifrice composition, and may be any crystalline cellulose that is usually used in dentifrice compositions, such as pulp powder, insoluble powdered cellulose. One or two or more kinds of powdered α-cellulose and those obtained by pulverizing cellulose such as pulp that have been insolubilized by chemical treatment can be used. In this case, the insolubilization by chemical treatment specifically means partial depolymerization with an acid such as a mineral acid.

The average particle size of the powdered cellulose is preferably 10 to 300 μm, particularly preferably 10 to 200 μm. If the average particle size is less than 10 μm, deterioration of the spinnability of the dentifrice composition cannot be prevented, and if it exceeds 300 μm, it is easy to put on the toothbrush. May be inferior.
The average particle size is the particle size at which the cumulative curve is calculated with the total powder volume measured by Microtrac being 100% and the cumulative curve is 50% (the same applies hereinafter). .

  As such powdered cellulose, commercially available ones may be used, for example, Asola Kasei Chemicals Co.

  The blending amount of the powdered cellulose is 0.1 to 4% by mass, preferably 0.3 to 3% by mass of the whole composition from the viewpoint of spinnability, ease of placing on a toothbrush, and the skin after storage. is there. If the blending amount is less than 0.1% by mass, the spinnability and ease of placement on a toothbrush are inferior, and if it exceeds 4% by mass, the ease of placement on a toothbrush and the skin after storage are inferior.

  The blending ratio of component (C) to component (B) ((C) / (B)) is 0.1 to 15 in terms of mass ratio in terms of spinnability, ease of placement on a toothbrush, and skin after storage. Preferably, it is 0.2-6. When (C) / (B) is less than 0.1, the spinnability and ease of placement on a toothbrush are poor, and when it exceeds 15, the ease of placement on a toothbrush and the skin after storage are poor.

In this invention, it is preferable to mix | blend (D) sweetener in order to suppress a bitter taste further.
As the sweetening agent, any of those usually used in dentifrice compositions may be used. Specific examples include sodium saccharin, aspartame, stevioside, stevia extract, paramethoxycinnamaldehyde, neohesperidyl. Examples include dihydrochalcone, perilartin, glycyrrhizin, thaumatin, aspartylphenylalanine methyl ester, and sodium saccharin is particularly preferable.

  (D) The blending amount of the sweetener is preferably from 0.1 to 1% by mass, particularly from 0.3 to 0.8% by mass, based on the whole composition. It cannot be obtained and the sweetness itself is weak, and if it exceeds 1% by mass, the sweetness is too strong, which may cause problems in use.

  (D) The sweetener is preferably blended such that (D) / (A) is 0.1 to 4, particularly 0.3 to 2, in terms of mass ratio with respect to the blending amount of component (A). If the blending ratio is less than 0.1, a satisfactory bitterness improving effect cannot be obtained, and the sweetness itself is weak, and if it exceeds 4, the sweetness is too strong, which may cause problems in use.

  In the dentifrice composition of the present invention, in addition to the components described above, various known components that are usually used in dentifrice compositions can be arbitrarily blended within a range that does not impair the effects of the present invention. Specific examples include cleaning agents, surfactants, wetting agents, binders, pigments, fragrances, pH adjusters, and various active ingredients.

  As cleaning agents (abrasives), silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, Examples thereof include zirconium silicate, hydroxyapatite, and a synthetic resin abrasive. The blending amount of the cleaning agent is preferably 0 to 60% by mass, particularly 10 to 20% by mass based on the total composition.

  As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.

Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristol sarcosine, dodecylbenzene sulfonic acid Sodium, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, etc. Can be mentioned.
Examples of the cationic surfactant include distearylmethylammonium chloride and stearyldimethylbenzylammonium chloride.

  Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Polyhydric alcohol fatty acid ester such as fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, ether type surfactant such as polyoxyethylene hydrogenated castor oil, lauric acid And fatty acid alkanolamides such as diethanolamide.

  Examples of amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryldiaminoethylglycine, N-alkyldiaminoethylglycine such as N-myristyldiaminoethylglycine, N- Alkyl-1-hydroxyethyl imidazoline betaine sodium etc. are mentioned.

  These surfactants may be used alone or in combination of two or more, and the blending amount can be 0.1 to 10% by mass of the whole composition.

  Examples of the wetting agent include sorbit, glycerin, propylene glycol, pentylene glycol, hexylene glycol, octylene glycol, xylitol, erythritol, polyethylene glycol having an average molecular weight of 200 to 6,000, ethylene glycol, 1,3-butylene glycol, and reduction. One type or two or more types of polyhydric alcohols such as saccharified starches can be blended. A compounding quantity is 5-70 mass% normally with respect to the whole composition.

  As the binder, in addition to xanthan gum and hydroxyalkyl cellulose, other than these may be blended within the range not hindering the effects of the present invention. For example, hydroxyalkyl cellulose such as sodium carboxymethyl cellulose, methyl cellulose, cationized cellulose and the like. 1 type, or 2 or more types, such as cellulose-based binder, carrageenan, guar gum, sodium alginate, montmorillonite, gelatin, and sodium polyacrylate. The amount added is usually 0.1 to 3% by mass of the total composition, but is preferably in the range of 0.2 to 6% by mass in total with the component (B).

  Examples of the pigment include legal pigments such as Blue No. 1, Yellow No. 4, and Green No. 3, natural pigments such as caramel, and titanium oxide. In addition, the compounding quantity of a pigment | dye can be 0.000001-1 mass% of the whole composition.

  As a fragrance, 1-menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil Orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like. As a compounding quantity of a fragrance | flavor, it can be set as 0.001-2 mass% of the whole composition.

  Examples of the pH adjuster include organic acids such as citric acid, lactic acid, malic acid or salts thereof, inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate, and the like. .

  In addition to these components, the dentifrice composition of the present invention includes medicinal ingredients or active ingredients such as dextranase, amylase, protease, mutanase, and other alkali metals, monofluorophosphates such as sodium monofluorophosphate, Sodium fluoride, fluoride such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamins and other anti-inflammatory agents, cetylpyridinium chloride, Bactericides such as benzalkonium chloride, triclosan, hinokitiol, lysozyme chloride, calculus preventives such as polyphosphates, tobacco spider removers such as polyvinylpyrrolidone, and amino acids such as glycine and proline can be added.

  The material in particular of the container which accommodates the dentifrice composition of this invention is not restrict | limited, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% indicates mass% unless otherwise specified.

[Examples and Comparative Examples]
A test dentifrice composition (toothpaste) containing the ingredients shown in Tables 1 to 7 was prepared in a conventional manner, and then filled into a laminated tube having an aperture of 8 mm. The following methods evaluated the thread property, the condensed skin after storage, and the ease of placing on a toothbrush. Further, the taste quality of the test dentifrice compositions having the compositions shown in Table 7 was evaluated by the following method. The results are shown in Tables 1-7. The main raw materials used in each composition are as shown in Table 8.

Evaluation of convergence:
The test dentifrice composition filled in a laminate tube having a diameter of 8 mm was evaluated by a sensory test by 10 expert panelists. About 1 g of the dentifrice composition was brushed for about 3 minutes for a toothbrush (manufactured by Lion Co., Ltd., Clinica Habrush 4 row head, medium), and then each subject compared with Comparative Example 1 with respect to the degree of convergence in the oral cavity. Sensory evaluation was performed according to the following scores and evaluation criteria.

<Score>
4 points: A feeling of convergence is felt very strongly compared to Comparative Example 1 3 points: A feeling of convergence is felt compared to Comparative Example 1 2 points: A feeling of convergence is felt slightly compared to Comparative Example 1 1 point: With Comparative Example 1 The evaluation results of 10 people who did not feel the same or no convergence were averaged, and the convergence was judged according to the following criteria.
<Evaluation criteria>
◎: Average score of convergent feeling 3.5 points to 4.0 points or less ○: Average score of convergent feeling 2.0 points to less than 3.5 points ×: Average score of convergent feeling 2.0 points Less than

Evaluation of liquid separation:
The test dentifrice composition filled in a laminated tube having a diameter of 8 mm was stored in a thermostatic bath at 50 ° C. for one month, and the liquid separation state when extruded from the tube onto paper was evaluated according to the following evaluation criteria.
<Evaluation criteria>
◎: Liquid separation is not recognized ○: Liquid separation is very slight (Gloss that is a sign of separation is recognized on the surface)
), But there is no problem in quality ×: Liquid separation is observed

Evaluation of stringiness:
About 1 g of the test dentifrice composition filled in an 8 mm diameter laminated tube on a toothbrush (manufactured by Lion Co., Ltd., Clinica Habrush 4 row head, medium), and then the toothbrush when the tube and brush are pulled upward The spinnability of the agent composition was tested. The stringiness refers to the property that the dentifrice composition stretches as if it is pulled out from a container such as a tube, and is an index of the goodness of the dentifrice composition. Measured and evaluated according to the following evaluation criteria.
<Evaluation criteria>
A: The length extended into a thread is less than 0.5 cm, and the kneading is good. ○: The length extended into a thread is from 0.5 cm to less than 1 cm, but there is no problem in use.
It is a level x: The length extended in the shape of a thread is 1 cm or more, and there is a problem in use.

Evaluation of ease of placement on toothbrush:
The ease of placement on a toothbrush when about 1 g of the test dentifrice composition filled in an 8 mm diameter laminated tube was placed on a toothbrush (Lion Corporation, Clinica Habrush 4 row head, medium) was evaluated according to the following evaluation criteria. evaluated.
<Evaluation criteria>
◎: The shape of the paste is kept on the toothbrush,
Does not roll off ○: The shape of the paste on the toothbrush is slightly broken or slightly solid
However, it does not sag from the toothbrush or roll off.
No problem level ×: The shape of the paste collapses on the toothbrush and falls off the toothbrush or the toothbrush
The dentifrice composition rolls off the toothbrush, although the shape remains on the pear.
There is a problem in use

Evaluation of condensed skin:
After the test dentifrice composition filled in an 8 mm diameter laminated tube was stored in a constant temperature bath at 40 ° C. for 3 months, the appearance of the dentifrice composition (extruded skin) when extruded from the tube after returning to room temperature was −5 ° C. The test dentifrice composition having the same composition stored for 3 months was used as a target product and evaluated according to the following evaluation criteria.
<Evaluation criteria>
A: Equivalent to the target product, the surface of the dentifrice composition has no wrinkles, and the surface gloss changes
○: Wrinkles on the surface of the dentifrice composition and no gloss on the surface compared to the target product
Slight deterioration is observed, but there is no problem with quality.
Level that is a quality problem

Evaluation of good taste:
The test dentifrice composition filled in a laminate tube having a diameter of 8 mm was evaluated by a sensory test by 10 expert panelists. About 1 g of the dentifrice composition was placed on a toothbrush (manufactured by Lion Corporation, Clinica Habrush 4 row head, medium) and brushed for 3 minutes, and the bitterness felt during use was sensoryly evaluated according to the following scores and evaluation criteria.

<Score>
4 points: Level that feels moderately sweet without feeling bitter 3 points: Feels slightly bitter, slightly sweet, or slightly
Level of sweetness is weak, but there is no problem in using dentifrice. 2 points: Feel bitterness, strong sweetness, or weak sweetness.
Levels that are problematic for use 1 point: Strong bitterness or very sweet or very weak
Therefore, there is a problem with the use of dentifrice <Evaluation criteria>
◎: Average score of bitterness score 3.5 to 4 points or less ○: Average score of bitterness score 3 to less than 3.5 points ×: Average score of bitterness score 3 points or less

  From the results of Tables 1 to 7, when the components (A) to (C) are blended in specific amounts and proportions, they are excellent in convergence, easy to put on a toothbrush and good spinnability, liquid separation and It was found that there was almost no deterioration of the skin. On the other hand, if the blending amount of the (A) copper compound and / or the zinc compound is small compared to the appropriate blending amount and blending ratio of each component according to the present invention, a satisfactory convergence feeling is not imparted (Comparative Example 1, 3) When too much, it was inferior in the ease of placing on a toothbrush, and after storage, liquid separation and deterioration of the skin were caused (Comparative Examples 2 and 4). (B) When the amount of xanthan gum and / or hydroxyethyl cellulose is small, it is inferior in ease of placing on a toothbrush, causing liquid separation after storage (Comparative Examples 5 and 7). (Comparative Examples 6 and 8). When carboxymethyl cellulose sodium (anionic cellulose derivative) was blended in place of xanthan gum and hydroxyethyl cellulose as a binder, it was inferior in ease of placement on a toothbrush, causing liquid separation after storage and deterioration of the skin ( Comparative Example 9). (C) If the blending amount of the powdered cellulose is small and inadequate, the spinnability and ease of placement on the toothbrush are poor (Comparative Example 10). If too much, the ease of placement on the toothbrush and the skin after storage deteriorates. (Comparative Example 11). Furthermore, if the blending ratio of the components (A) and (B) ((B) / (A)) is inappropriate, the ease of placement on the toothbrush and the spinnability will be poor, and the liquid will be separated and the skin will deteriorate after storage. (Comparative Examples 12 and 13). When the blending ratio of the components (B) and (C) ((C) / (B)) is inappropriate, the stringiness and ease of placement on a toothbrush are inferior, and the skin after storage has deteriorated. (Comparative Examples 14 and 15).

  In addition, the copper gluconate of Example 1,3,5-29,55-82,84,85 is a copper citrate (the Kanto Chemical Co., Ltd. make, brand name: Copper (II) citrate * 2.5 water). As a result of blending with the same composition except that it was replaced with, a result similar to that obtained when copper gluconate was used was obtained. Furthermore, the zinc oxides of Examples 2, 4, 30 to 54, 80, 81, 83 were zinc chloride (manufactured by Kanto Chemical Co., Ltd., trade name: zinc chloride), zinc carbonate (manufactured by Kanto Chemical Co., Ltd., trade name). : Zinc carbonate (basic)), zinc citrate (manufactured by Kanto Chemical Co., Ltd., trade name: zinc citrate) Results were obtained.

From these results, (A) copper compound and / or zinc compound, (B) xanthan gum and / or hydroxyalkyl cellulose are blended in a specific amount and a specific ratio, and (C) powdered cellulose is blended in a specific amount and a specific ratio. Therefore, it is possible to obtain a dentifrice composition that has a strong converging feeling during use, has almost no liquid separation after storage, and no deterioration of the skin, and has good spinnability and ease of placement on a toothbrush. I understood.
Furthermore, from the results of Table 7, it was found that when (D) the sweetener was further blended in a specific amount and proportion, the bitterness was suppressed and the feeling of use was improved while having the above-described excellent characteristics.

Claims (4)

(A) 0.1-3 mass% of copper compound and / or zinc compound,
(B) 0.1 to 3% by mass of xanthan gum and / or hydroxyalkyl cellulose;
(C) 0.1-4 mass% of powdered cellulose
Dentifrice composition characterized by containing (B) / (A) 0.1-15 and (C) / (B) 0.1-15 by mass ratio.   The dentifrice composition according to claim 1, wherein the copper compound and / or the zinc compound is at least one selected from copper gluconate, copper citrate, zinc oxide, zinc chloride, zinc carbonate, and zinc citrate.   Furthermore, (D) 0.1-1 mass% of sweeteners are contained, The dentifrice composition of Claim 1 or 2 characterized by the above-mentioned.   The dentifrice composition according to claim 3, wherein the mass ratio of (D) / (A) is 0.1-4.