JP7347916B2 - dentifrice composition - Google Patents

Description

The present invention relates to a dentifrice composition that prevents liquid from dripping from the mouth when brushing teeth, provides a refreshing feeling, and has an excellent feeling of use.

When using oral compositions, especially dentifrice compositions, dripping, such as foam or liquid dripping from the mouth, not only reduces the effectiveness of the product but also tends to be perceived as an unpleasant feeling when using the product. It is also important that the inside of the mouth is cleaned and refreshed after brushing the teeth.

Dentifrice compositions usually contain abrasives, surfactants, wetting agents, binders, etc., and anionic surfactants are used as surfactants to foam and ensure cleanability. In addition, various water-soluble polymer substances are used as binders for the purpose of maintaining appropriate viscosity, shape retention, etc. However, if you brush your teeth using a dentifrice composition (usually for about 3 minutes), even if you can brush your teeth without foam dripping out of your mouth at the beginning, the foam will gradually build up as time passes. However, there is room for improvement in order to obtain a dentifrice composition that prevents dripping and provides a comfortable brushing experience and a satisfactory feeling of use.

On the other hand, carbonates such as sodium bicarbonate are used for various purposes as ingredients for oral compositions such as dentifrices, and techniques related to specifically blending bicarbonates are proposed in Patent Documents 1 to 7. has been done.

Japanese Patent Application Publication No. 8-333228 Japanese Patent Application Publication No. 9-132517 Japanese Patent Application Publication No. 11-1418 Japanese Patent Application Publication No. 2002-104945 Japanese Patent Application Publication No. 2002-302450 JP2009-137908A International Publication No. 2013/094312

The present invention was made in view of the above circumstances, and it is an object of the present invention to provide a dentifrice composition that prevents liquid from dripping from the mouth during tooth brushing, provides a refreshing feeling, and has an excellent feeling of use.

The present inventors conducted intensive studies to achieve the above object, and found that a dentifrice composition contains a specific amount or more of an anionic surfactant, a specific amount or more of xanthan gum, and further contains hydrogen carbonate. When blended in a specific amount or less, it can prevent foam and liquid from dripping from the mouth when brushing teeth, provide a satisfying refreshing feeling, and moderate irritation, resulting in an excellent feeling of use. The present inventors have discovered that it is possible to provide the same, and have come up with the present invention.
In addition, in the present invention, it has been found that when sodium polyacrylate or sodium alginate is further blended, the dispersibility of the preparation in the oral cavity is improved, and the feeling of use is further improved.

That is, in the present invention, (A) 1.4 to 2.5% by mass of anionic surfactant, (B) 1.4 to 2.5% by mass of xanthan gum, and (C) 0.1 to 0.1 to 2.5% by mass of hydrogen carbonate. By using a relatively large amount of (B) xanthan gum, the foaming performance is improved, preventing dripping when brushing teeth, and at the same time providing a satisfying refreshing feeling and reducing irritation. It can also be suppressed.
In this case, in order to improve the feeling of use of the dentifrice composition, if (A) anionic surfactant is added in a relatively large amount for the purpose of improving foaming, although the foaming can be improved, tooth brushing will start. However, by combining (B) xanthan gum in a specific amount or more, this can effectively prevent fluid from dripping from the mouth when brushing teeth. , it was also possible to provide sustained protection over a long period of time. However, in this case, the combined use of components (A) and (B) caused another problem in that the refreshing feeling after rinsing the mouth during tooth brushing was impaired and the feeling of use was reduced. Therefore, further investigation revealed that by blending (C) hydrogen carbonate in a specific amount or less, dripping could be prevented without causing the problem of reduced refreshing sensation as described above. In addition, although hydrogen carbonate has the effect of improving the feeling of use, if the component (A) is blended in more than a certain amount and too much hydrogen carbonate is blended, the irritation will be strong. By combining the three components (C) in specific amounts, it was surprisingly possible to prevent dripping and provide a refreshing feeling, thereby improving the feeling of use and providing exceptional effects.
In dentifrice compositions, xanthan gum, which may affect stringiness as a binder, is often used in an amount less than 1% by mass, but in the present invention, xanthan gum is used in an amount of 1.4% by mass or more. By doing so, the above-mentioned effects are unexpectedly achieved.
As shown in the examples below, the dentifrice composition containing the components (A), (B), and (C) of the present invention is effective after more than 1 minute, or even more than 2 minutes, after the start of tooth brushing. Also, dripping from the mouth is suppressed, and there is no dripping, and the refreshing feeling and lack of irritation are also excellent. On the other hand, as shown in the comparative example, if any of the components (A), (B), and (C) is missing, or even if the three are combined, the amount of any one of them is inappropriate. , the effect of the present invention is inferior.

Therefore, the present invention provides the following dentifrice composition.
[1]
(A) anionic surfactant 1.4 to 2.5% by mass,
(B) xanthan gum 1.4 to 2.5% by mass,
(C) Hydrogen carbonate 0.1 to 5% by mass
A dentifrice composition characterized by containing.
[2]
The dentifrice composition according to [1], wherein the component (A) is an anionic surfactant containing a sulfonic acid group.
[3]
(C) The dentifrice composition according to [1] or [2], wherein the hydrogen carbonate is sodium hydrogen carbonate, and the content thereof is 0.1 to 3% by mass.
[4]
The dentifrice composition according to any one of [1] to [3], wherein (A)/(B) is 0.7 to 1.7 as a mass ratio.
[5]
The dentifrice composition according to any one of [1] to [4], further comprising (D) 0.1 to 1% by mass of sodium polyacrylate and/or sodium alginate.
[6]
The dentifrice composition according to [5], wherein (B)/(D) is 1.5 to 20 as a mass ratio.
[7]
The dentifrice composition according to any one of [1] to [6], further comprising (E) 8 to 70% by mass of an abrasive.

According to the present invention, it is possible to provide a dentifrice composition that prevents liquid from dripping from the mouth during tooth brushing, provides a refreshing feeling, and has an excellent feeling of use.

The present invention will be explained in more detail below. The dentifrice composition of the present invention contains (A) an anionic surfactant, (B) xanthan gum, and (C) bicarbonate in specific amounts.

(A) Anionic surfactants include N-acyl sulfates, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, lauryl sulfoacetates, N-methyl-N-acyl taurate salts, etc. Examples include acyl amino acid salts such as taurate, acyl sarcosine salt, and N-acyl-L-glutamate. These can be used alone or in combination of two or more. Among these, from the viewpoint of foaming, anionic surfactants containing sulfonic acid groups are preferred, and alkyl sulfates and α-olefin sulfonates are more preferred. Examples of the salts include sodium salts, potassium salts, ammonium salts, and the like, with sodium salts being particularly preferred.
The alkyl sulfate preferably has an alkyl group having 10 to 14 carbon atoms, and specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
As the α-olefin sulfonate, an alkali metal salt such as sodium or potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and among them, α-olefin sulfonate having 14 carbon atoms, especially sodium Salt (common name: sodium tetradecene sulfonate) is preferred. These are commercially available products that can be used in oral preparations, and for example, the product name "K-Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

Note that anionic surfactants that do not have sulfonic acid groups, especially acylamino acid salts such as N-acyl-L-glutamate, may produce weak foaming when combined with components (B) and (C). In this respect, anionic surfactants containing sulfonic acid groups, particularly alkyl sulfates and α-olefin sulfonates, are preferred as component (A).

The blending amount of the anionic surfactant (A) is 1.4 to 2.5% (mass%, hereinafter the same) of the entire composition, preferably 1.6 to 2.0%. If the blending amount is less than 1.4%, foaming will be reduced, the lack of dripping will be poor, and the refreshing feeling will be poor. If it exceeds 2.5%, the stimulation becomes strong. The blending amount range of each of the anionic surfactants mentioned above may be the same as above.

The amount of xanthan gum (B) is 1.4 to 2.5% of the total composition, preferably 1.5 to 2.0%, more preferably 1.6 to 2.0%. When the blending amount is less than 1.4%, dripping cannot be prevented continuously and the lack of dripping is poor. If it exceeds 2.5%, the refreshing feeling will decrease. In addition, the preparation becomes too hard, making it difficult to use.

(A)/(B), which indicates the blending ratio of (A) anionic surfactant and (B) xanthan gum, is preferably 0.7 to 1.7 as a mass ratio, more preferably 0.9 to 1. It is 3. Within this range, dripping can be further prevented, the refreshing feeling can be further improved, and irritation can be further suppressed. If it is less than 0.7, the refreshing feeling may be insufficient, and if it exceeds 1.7, dripping may not be sufficiently prevented or irritation may become strong.

(C) As the hydrogen carbonate, sodium hydrogen carbonate can be used.
(C) The amount of hydrogen carbonate added is 0.1 to 5% of the entire composition, preferably 0.1 to 3%, more preferably 0.3 to 2%, and even more preferably 0.3 to 3%. It is 1%. If it is less than 0.1%, the refreshing feeling will be insufficient, and if it exceeds 5%, irritation and discomfort will be strong, and dripping may not be sufficiently prevented.

In the present invention, it is preferable to further include (D) sodium polyacrylate and/or sodium alginate. When component (D) is blended, the dispersibility of the dentifrice composition in the oral cavity is improved and the usability is further enhanced.
Component (D) may be either sodium polyacrylate or sodium alginate, but both may be used in combination in order to achieve the desired effect.
The blending amount of component (D) is preferably 0.1 to 1%, more preferably 0.3 to 1% of the total composition. When the content is 0.1% or more, the dispersibility in the oral cavity is sufficiently improved. If it exceeds 1%, the formulation may become too hard.

(B)/(D), which indicates the blending ratio of (B) xanthan gum and (D) sodium polyacrylate and/or sodium alginate, is preferably from 1.5 to 20 as a mass ratio, more preferably from 1.6 to 16, more preferably 2-10. Within this range, the dispersibility in the oral cavity is further improved, and it is also suitable for maintaining appropriate formulation hardness.

The dentifrice composition of the present invention may further contain (E) an abrasive.
As abrasives, calcium phosphate compounds such as dicalcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-binding silica, etc. silica-based abrasives; calcium carbonate-based abrasives such as calcium carbonate; abrasive particles such as calcium hydroxide, aluminum hydroxide, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite; One type or two or more types can be blended. Among these, silica-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, calcium carbonate-based abrasives, and especially silica-based abrasives such as precipitated silica. Abrasives are preferred.
As the silica-based abrasive, commercially available products can be used, such as Zeodent 124 and Zeodent 113 manufactured by HUBER, TIXOSIL 73 and TIXOSIL 63 manufactured by Rhodia, Side 3 and Side 20 manufactured by Degussa, and Sident 20 manufactured by Taki Chemical Co., Ltd. Examples include zirconosilicate and aluminosilicate.
The amount of abrasive to be blended is preferably 8 to 70%, particularly 10 to 50% of the total composition.

Further, the abrasive may be in the form of granules, and granules can be blended as a component having abrasive properties. The granules are particles formed by forming water-insoluble powder into granules, and granules using a binder may be used for granulation.
Water-insoluble powders include dibasic calcium phosphate, tribasic calcium phosphate, water-insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, red iron, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, zirconosilicate. , inorganic powders such as calcium sulfate, and mixtures thereof, with silica granules and zeolite granules being particularly suitable.
As the abrasive, the above-mentioned abrasive particles and granules may be used in combination.

The dentifrice composition of the present invention is particularly suitable as a dentifrice, and can be prepared by known methods. Further, in addition to the above-mentioned components, known components normally used in dentifrice compositions can be blended as needed within a range that does not impair the effects of the present invention. The optional ingredients that can be blended include binders other than components (B) and (D), surfactants other than component (A), wetting agents, sweeteners, fragrances, pH adjusters, preservatives, medicinal ingredients, etc. can be mentioned.

As a binder, substances other than xanthan gum, sodium polyacrylate and sodium alginate, such as inorganic binders such as thickening silica and aluminum silicate; sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, gum tragacanth , karaya gum, arabic gum, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbopol, vegum, propylene glycol alginate, and other organic binders may be blended.

As the thickening silica, it is possible to use silica obtained by a known manufacturing method and having a liquid absorption amount in the range of 2 to 5 ml/g. The method for measuring the liquid absorption amount is as follows.
Weigh 1.0 g of the sample onto a clean glass plate, and using a microburette, mix the sample with a stainless steel spatula while dropping 42.5% glycerin little by little so that the liquid becomes uniform. The end point is when the sample forms a lump and can be peeled off cleanly from the glass plate with a spatula, and the amount of liquid (ml) required is defined as the amount of liquid absorbed.
Specific examples of such thickening silica include Tokusil manufactured by Tokuyama Soda Co., Ltd., SORBOSIL TC15 manufactured by PQ Corporation, TIXOSIL 43 manufactured by Rhodia, Zeodent 153 manufactured by HUBER, and DSL Japan Co., Ltd. Commercially available products such as Carplex #67Q manufactured by Manufacturer Co., Ltd. can be used.

As carboxymethylcellulose sodium, one having an average degree of substitution (DS degree) of carboxymethyl groups of 0.5 to 1.5 can be suitably used.
Preferred carboxymethyl cellulose sodium has a viscosity of 15 to 3,000 mPa·s (2% aqueous solution, measured using a B-type viscometer at 20°C, the same applies hereinafter).
The above viscosity is a value measured using a B8H type viscometer (for example, manufactured by Tokyo Keiki Co., Ltd.) using rotors numbered 1 to 4 according to the viscosity range. For example, if the viscosity is less than 100 mPa・s, measure the viscosity after 3 minutes at 50 rpm using rotor no. The viscosity after minutes can be measured.
As such sodium carboxymethyl cellulose, commercially available products such as CMC Daicel sold by Daicel Finechem Co., Ltd., Celogen made by Daiichi Kogyo Seiyaku Co., Ltd., and Sunrose made by Nippon Paper Industries Co., Ltd. can be used.

The amount of the inorganic binder to be blended is preferably 0 to 10%, preferably 0.5 to 10%, and more preferably 1 to 8% of the total composition. Further, the content of organic binders other than components (B) and (D) is preferably 0 to 3%.

Examples of the surfactant include nonionic surfactants and amphoteric surfactants, which can be used alone or in combination of two or more.
Nonionic surfactants include polyoxyethylene hydrogenated castor oil; polyoxyethylene fatty acid ester; polyglycerin fatty acid ester; sucrose fatty acid ester such as maltose fatty acid ester; sugar alcohol fatty acid such as maltitol fatty acid ester and lactitol fatty acid ester. Ester; Alkylolamide; Polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate; Fatty acid diethanolamide such as lauric acid mono- or diethanolamide; Sorbitan fatty acid ester; Polyoxyethylene alkyl ether; Polyoxyethylene polyoxypropylene Copolymers; examples include polyoxyethylene polyoxypropylene fatty acid esters. The nonionic surfactant may be added in an amount of 10% or less of the total composition, and may be 0%.
Examples of amphoteric surfactants include fatty acid amidopropyl betaine such as cocamidopropyl betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine; imidazoline type amphoteric surfactants such as coconut oil fatty acid imidazolium betaine; Betaine is preferred. The zwitterionic surfactant can be blended in an amount of 10% or less of the total composition, and may be 0%.

Wetting agents include sorbitol, glycerin, propylene glycol, polyethylene glycol with an average molecular weight of 200 to 6,000 (average molecular weight stated in the standards for quasi-drug raw materials), ethylene glycol, 1,3-butylene glycol, erythritol, xylitol. , trimethylglycine, polyhydric alcohols such as reduced starch saccharides, and sugar alcohols.
The amount of these wetting agents added is preferably 0.1 to 70% of the total composition.

Examples of sweeteners include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester, and the like.

Examples of fragrances include known fragrances, such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyllinalool, vanillin, thymol, spearmint oil, and peppermint oil. , lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil and the like.

Examples of the pH adjuster include organic acids such as citric acid and lactic acid and their salts; and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
Examples of the preservative include paraoxybenzoic acid ester, sodium benzoate, and the like.

Medicinal ingredients include enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, and glycyrrhetinate; sodium chloride, vitamins, allantoin, etc. Cell activators; Bactericidal agents such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; Water-soluble copper compounds such as copper chlorophyll and copper gluconate; Pyrophosphates, polyphosphates, hexametaphosphates , tartar prevention agents such as zeolite; blood circulation promoters such as vitamin E; amino acids such as alanine, glycine, and proline; and plant extracts such as rosemary and birch. The amount of medicinal ingredients to be blended can be set to an effective amount within a range that does not impede the effects of the present invention.

Furthermore, as optional ingredients, inorganic compounds such as mica titanium, titanium oxide, and bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, and glucomannan; polyvinyl acetate, and acrylic resins. Synthetic polymer compounds such as , polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder, etc., or copolymers thereof; Waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; Setanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, natural rubber, etc. can be blended within a range that does not impede the effects of the present invention.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to Examples and Comparative Examples, but the present invention is not limited to the Examples below. In addition, in the following examples, % indicates mass % unless otherwise specified.

[Examples, comparative examples]
Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods, used as samples, and evaluated by the methods shown in (1) to (3) below. Furthermore, the compositions shown in Table 3 were also evaluated by the method shown in (4) below. The results are also listed in the table.

<Evaluation method>
(1) No dripping A panel of experts (subjects, n = 3) took 1 g of sample on a toothbrush and brushed their teeth for 3 minutes. Judgment was made using the following scoring criteria. The average value of the three people's ratings was calculated and evaluated based on the following evaluation criteria.
Scoring Criteria 4 points: The sample did not drip from the mouth even after 3 minutes had passed after tooth brushing started. 3 points: The sample dripped from the mouth more than 2 minutes but within 3 minutes after tooth brushing started. 2 points: After tooth brushing started. The sample dripped from the mouth within 2 minutes after 1 minute. 1 point: The sample dripped from the mouth within 1 minute after starting brushing. Evaluation criteria ◎: 3.5 points or more ○: Over 2.0 points Less than 3.5 points ×: 2.0 points or less

(2) Refreshing feeling Expert panelists (subjects, n = 3) took 1 g of sample on a toothbrush, brushed their teeth for 3 minutes, and rinsed their mouth with water.Then, they evaluated the refreshing feeling using the following rating criteria. . The average value of the three people's ratings was calculated and evaluated based on the following evaluation criteria.
Rating criteria 4 points: I felt very refreshed 3 points: I felt very refreshed 2 points: I felt somewhat refreshed 1 point: I did not feel refreshed Evaluation standards ◎: 3.0 points or more ○: 2.0 points or more and less than 3.0 points ×: less than 2.0 points

(3) Lack of irritation Expert panelists (subjects, n = 3) took 1 g of sample on a toothbrush, brushed their teeth for 3 minutes, and rinsed their mouths with water. Afterwards, they judged the sensation of irritation using the following rating criteria: did. The average value of the three people's ratings was calculated and evaluated based on the following evaluation criteria.
Rating criteria 4 points: I didn't feel any stimulation 3 points: I almost didn't feel any stimulation 2 points: I felt some stimulation 1 point: I felt strong stimulation Evaluation criteria ◎: 3.5 points or more ○: 2.5 points More than 3.5 points ×: Less than 2.5 points

(4) Dispersibility in the oral cavity Expert panelists (n = 3) took 1 g of sample on a toothbrush and judged the dispersibility of the paste in the oral cavity after starting tooth brushing using the following scoring criteria. . The average value of the three people's ratings was calculated and evaluated based on the following evaluation criteria.
Scoring Criteria: 4 points: The dispersibility of the paste was very good. 3 points: The dispersibility of the paste was quite good. 2 points: The dispersibility of the paste was somewhat good. 1 point: The dispersibility of the paste was not good. Evaluation Criteria: ◎: 3. 0 points or more ○: 2.5 points or more and less than 3.0 points ×: less than 2.5 points

Details of the raw materials used are shown below.
(A) Sodium lauryl sulfate: Texapon (manufactured by BASF)
(A) Sodium tetradecene sulfonate:
K-Reporan PJ-400CJ (manufactured by Lion Specialty Chemicals Co., Ltd.)
(B) Xanthan gum: Monart gum DA (manufactured by CP Kelco)
Sodium carboxymethyl cellulose (comparative product, manufactured by Daicel Finechem Ltd.)
(C) Sodium bicarbonate: Sodium bicarbonate (manufactured by Asahi Glass Co., Ltd.)
(D) Sodium polyacrylate: Rheosic 260H (manufactured by Toagosei Co., Ltd.)
(D) Sodium alginate: Kimica Algin (manufactured by Kimica Co., Ltd.)
Abrasive silica: TIXOSIL 73 (manufactured by Rhodia)
Thickening silica: Carplex #67 (manufactured by DSL Japan Co., Ltd.)

*; Reference example

Claims (8)

(A) anionic surfactant 1.4 to 2.5% by mass,
(B) xanthan gum 1.4 to 2.5% by mass,
(C) Hydrogen carbonate 0.1 to 5% by mass
and
(D) Sodium polyacrylate and/or sodium alginate 0.1 to 1% by mass
A dentifrice composition characterized by containing. The dentifrice composition according to claim 1, wherein component (A) is an anionic surfactant containing a sulfonic acid group. The dentifrice composition according to claim 1 or 2, wherein the hydrogen carbonate (C) is sodium hydrogen carbonate, and its content is 0.1 to 3% by mass. The dentifrice composition according to any one of claims 1 to 3, wherein the content of component (C) is 0.3 to 1% by mass. The dentifrice composition according to any one of claims 1 to 4, wherein (A)/(B) is a mass ratio of 0.7 to 1.7. The dentifrice composition according to claim 5, wherein (A)/(B) is a mass ratio of 0.9 to 1.3. The dentifrice composition according to any one of claims 1 to 6, wherein (B)/(D) is in a mass ratio of 1.5 to 20. The dentifrice composition according to any one of claims 1 to 7 , further comprising (E) an abrasive in an amount of 8 to 70% by mass.