WO2018221609A1 - Dentifrice composition - Google Patents
Dentifrice composition Download PDFInfo
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- WO2018221609A1 WO2018221609A1 PCT/JP2018/020807 JP2018020807W WO2018221609A1 WO 2018221609 A1 WO2018221609 A1 WO 2018221609A1 JP 2018020807 W JP2018020807 W JP 2018020807W WO 2018221609 A1 WO2018221609 A1 WO 2018221609A1
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- dentifrice composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Definitions
- the present invention relates to a dentifrice composition that prevents dripping from the mouth when brushing teeth, provides a refreshing feeling, and is excellent in use feeling.
- dripping of preparations such as dripping foam or dripping from the mouth not only reduces its effectiveness but is also easily recognized as an unpleasant feeling of use. It is also important to give an actual feeling that the mouth has been cleaned and refreshed after brushing.
- a dentifrice composition usually contains a polishing agent, a surfactant, a wetting agent, a binder, and the like, and an anionic surfactant is foamed as a surfactant, and is used for ensuring cleaning properties and the like.
- various water-soluble polymer substances are used as binders for the purpose of maintaining proper viscosity and shape retention.
- JP-A-8-333228 JP-A-9-132517 Japanese Patent Laid-Open No. 11-1418 JP 2002-104945 A JP 2002-302450 A JP 2009-137908 A International Publication No. 2013/094312
- the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition that prevents dripping from the mouth when brushing teeth, gives a refreshing feeling, and is excellent in use feeling.
- the present inventors have formulated a specific amount or more of an anionic surfactant in a dentifrice composition, blended a specific amount or more of xanthan gum, and further added a bicarbonate.
- an anionic surfactant in a dentifrice composition
- blended a specific amount or more of xanthan gum
- a bicarbonate When blended at a specific amount or less, it prevents foam or liquid from dripping from the mouth when brushing teeth, gives a refreshing feeling satisfactorily, and can suppress irritation moderately. It has been found that it can be imparted, and has led to the present invention.
- polyacrylic acid sodium or sodium alginate was further mix
- foam performance can be improved, dripping at the time of tooth brushing can be prevented, and at the same time a satisfactory refreshing feeling can be imparted. It can also be suppressed.
- (A) an anionic surfactant is blended in a relatively large amount for the purpose of improving foaming, toothbrushing is started even if foaming can be improved.
- bicarbonate has an effect of improving the feeling of use
- (A) component is blended more than a specific amount and too much bicarbonate is blended, irritation becomes strong
- (A), (B) and (C) By combining each of the three components (C) in specific amounts, surprisingly both the prevention of dripping and the provision of a refreshing feeling can be achieved, and the feeling of use can be improved, and an exceptional effect can be imparted.
- xanthan gum that may affect spinnability as a binder is often used in an amount of less than 1% by mass, but in the present invention, xanthan gum is used in an amount of 1.4% by mass or more.
- blended (A), (B) and (C) component of this invention is 1 minute after the start of toothpaste, Furthermore, more than 2 minutes passed. In addition, the dripping from the mouth was suppressed, the dripping was excellent, and the refreshing feeling and lack of irritation were also excellent.
- the blending amount is inappropriate. The effect of the present invention was inferior.
- the present invention provides the following dentifrice composition.
- a dentifrice composition containing [2] (A) Dentifrice composition as described in [1] whose component is an anionic surfactant containing a sulfonic acid group. [3] (C) The dentifrice composition according to [1] or [2], wherein the bicarbonate is sodium bicarbonate and the content thereof is 0.1 to 3% by mass.
- a dentifrice composition that prevents dripping from the mouth during tooth brushing, gives a refreshing feeling, and is excellent in use feeling.
- the dentifrice composition of the present invention contains (A) an anionic surfactant, (B) xanthan gum, and (C) a bicarbonate in specific amounts.
- Anionic surfactants include N-acyl such as alkyl sulfate, ⁇ -olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-methyl-N-acyl taurate, etc.
- Examples include acyl amino acid salts such as taurate, acyl sarcosine salts, and N-acyl-L-glutamate. These can be used alone or in combination of two or more.
- anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of foaming, and alkyl sulfates and ⁇ -olefin sulfonates are more preferable.
- the salt examples include sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.
- the alkyl sulfate the alkyl group preferably has 10 to 14 carbon atoms.
- Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
- alkali metal salts such as sodium and potassium of ⁇ -olefin sulfonate having 14 to 16 carbon atoms can be used, and among them, ⁇ -olefin sulfonate having 14 carbon atoms, particularly sodium.
- Salts (generic name; sodium tetradecene sulfonate) are preferred.
- Commercially available products that can be used for oral preparations can be obtained.
- “K Liporan PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
- anionic surfactants having no sulfonic acid group may have weak foaming when combined with the components (B) and (C).
- anionic surfactants containing a sulfonic acid group as the component (A), particularly alkyl sulfates and ⁇ -olefin sulfonates are preferred.
- the compounding amount of the anionic surfactant is 1.4 to 2.5% (mass%, the same applies hereinafter) of the whole composition, and preferably 1.6 to 2.0%. If the blending amount is less than 1.4%, foaming is reduced, the lack of dripping is inferior, and the refreshing feeling is inferior. When it exceeds 2.5%, the stimulation becomes stronger.
- each compounding quantity range of the anionic surfactant mentioned above may be the same as the above.
- the compounding amount of xanthan gum is 1.4 to 2.5% of the total composition, preferably 1.5 to 2.0%, more preferably 1.6 to 2.0%. If the blending amount is less than 1.4%, dripping cannot be prevented continuously, and the lack of dripping is inferior. When it exceeds 2.5%, the refreshing feeling is lowered. In addition, the preparation becomes too hard and the usability deteriorates.
- (A) / (B) showing the blending ratio of (A) anionic surfactant and (B) xanthan gum is preferably 0.7 to 1.7, more preferably 0.9 to 1. 3. Within this range, dripping can be further prevented, a refreshing feeling can be further improved, and stimulation can be further suppressed. If it is less than 0.7, the refreshing feeling may be insufficient, and if it exceeds 1.7, dripping may not be sufficiently prevented or irritation may be increased.
- (C) Sodium bicarbonate can be used as the bicarbonate.
- the blending amount of (C) bicarbonate is 0.1 to 5% of the entire composition, preferably 0.1 to 3%, more preferably 0.3 to 2%, and still more preferably 0.3 to 1%. If it is less than 0.1%, the feeling of refreshing is insufficient, and if it exceeds 5%, irritation and discomfort may become strong, and dripping may not be sufficiently prevented.
- component (D) sodium polyacrylate and / or sodium alginate.
- component (D) may be either sodium polyacrylate or sodium alginate, but both may be used together in terms of effect.
- the blending amount of component (D) is preferably 0.1 to 1%, more preferably 0.3 to 1% of the entire composition. If it is 0.1% or more, dispersibility in the oral cavity is sufficiently improved. If it exceeds 1%, the preparation may become too hard.
- (B) / (D) indicating the blending ratio of (B) xanthan gum and (D) sodium polyacrylate and / or sodium alginate is preferably 1.5 to 20, more preferably 1.6 to 16, more preferably 2 to 10. Within this range, dispersibility in the oral cavity is further improved, and it is also suitable for appropriate maintenance of formulation hardness.
- the dentifrice composition of the present invention can further contain (E) an abrasive.
- an abrasive calcium phosphate abrasives such as dicalcium phosphate dihydrate or anhydrous, primary calcium phosphate, tertiary calcium phosphate, calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-binding silica
- Silica-based abrasives such as calcium carbonate-based abrasives such as calcium carbonate, and abrasive particles such as calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, etc.
- silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, especially silica-based materials such as precipitated silica.
- Abrasives are preferred.
- Commercially available products can be used as the silica-based abrasive, such as Zeodent 124 and Zedent 113 manufactured by HUBER, TIXOSIL 73 and TIXOSIL 63 manufactured by Rhodia, Sident 3 and Sident 20 manufactured by Degussa, and manufactured by Taki Chemical Co., Ltd. Zirconosilicate, aluminosilicate and the like.
- the blending amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the whole composition.
- the abrasive may be granular, and granules can be blended as an abrasive component.
- the granule is a particle in which a water-insoluble powder is formed into a granule, and a granulated product using a binder may be used for granulation.
- water-insoluble powder dicalcium phosphate, tricalcium phosphate, water-insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, bengara, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, zirconosilicate Inorganic powders such as calcium sulfate and mixtures thereof can be mentioned, and silica granules and zeolite granules are particularly suitable.
- the abrasive the above-described abrasive particles and granules may be used in combination.
- the dentifrice composition of the present invention is particularly suitable as a toothpaste and can be prepared by a known method.
- the well-known component normally used for the dentifrice composition can be mix
- the optional components that can be blended include binders other than the components (B) and (D), surfactants other than the component (A), wetting agents, sweeteners, fragrances, pH adjusters, preservatives, medicinal components, and the like. Is mentioned.
- Binders include inorganic binders such as thickening silica and aluminum silicate; sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, caraya gum, arabiya gum, locust bean gum, polyvinyl alcohol, carboxyvinyl You may mix
- the thickening silica silica obtained by a known production method having a liquid absorption amount of 2 to 5 ml / g can be used.
- the measuring method of the amount of liquid absorption is as follows. Weigh 1.0 g of a sample on a clean glass plate, and mix the sample with a stainless steel spatula using a microburet while dripping 42.5% glycerin little by little. The end point is when the sample becomes one lump and comes off cleanly from the glass plate with a spatula, and the required liquid volume (ml) is the liquid absorption.
- Specific examples of such a thickening silica include Tokuyama Soda Co., Ltd. Tokusil, PQ Corporation SORBOSIL TC15, Rhodia TIXOSIL 43, HUBER Zeodent 153, DSL Japan Co., Ltd. Commercially available products such as Carplex # 67Q made by the manufacturer can be used.
- sodium carboxymethylcellulose those having an average substitution degree (DS conversion degree) of carboxymethyl group of 0.5 to 1.5 can be preferably used.
- Sodium carboxymethylcellulose having a viscosity of 15 to 3,000 mPa ⁇ s (2% aqueous solution, measured with a B-type viscometer at 20 ° C., the same shall apply hereinafter) is preferable.
- the viscosity is a value measured using a B8H type viscometer (for example, manufactured by Tokyo Keiki Co., Ltd.) and using a No. 1 to 4 rotor according to the viscosity range. For example, when the viscosity is less than 100 mPa ⁇ s, the viscosity after 3 minutes at 50 rpm using the No.
- the blending amount of these binders is preferably 0 to 10%, preferably 0.5 to 10%, more preferably 1 to 8% of the total composition of the inorganic binder.
- the organic binder other than the components (B) and (D) is preferably 0 to 3%.
- Nonionic surfactants include: polyoxyethylene hydrogenated castor oil; polyoxyethylene fatty acid ester; polyglycerin fatty acid ester; sucrose fatty acid ester such as maltose fatty acid ester; sugar alcohol fatty acid such as maltitol fatty acid ester and lactitol fatty acid ester Esters; alkylol amides; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate; fatty acid diethanolamides such as lauric acid mono- or diethanolamide; sorbitan fatty acid esters; polyoxyethylene alkyl ethers; polyoxyethylene polyoxypropylene Copolymer; polyoxyethylene polyoxypropylene fatty acid ester.
- the nonionic surfactant can be blended in an amount of 10% or less of the entire composition, and may be 0%.
- amphoteric surfactants include fatty acid amidopropyl betaines such as cocamidopropyl betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine; imidazoline type amphoteric surfactants such as coconut oil fatty acid imidazolium betaine, and fatty acid amidopropyl betaines. Is preferred.
- the zwitterionic surfactant can be added in an amount of 10% or less of the entire composition, and may be 0%.
- Wetting agents include sorbit, glycerin, propylene glycol, polyethylene glycol, ethylene glycol, 1,3-butylene glycol, erythritol, xylitol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications) And polyhydric alcohols such as trimethylglycine and reduced starch saccharified product, and sugar alcohols.
- the blending amount of these wetting agents is preferably 0.1 to 70% of the entire composition.
- Sweetening agents include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like.
- fragrance known fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, ⁇ -terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil , Lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like.
- Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
- Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
- Medicinal ingredients include enzymes such as dextranase, amylase, protease, mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate; sodium chloride, vitamins, allantoins, etc.
- enzymes such as dextranase, amylase, protease, mutanase
- anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate
- sodium chloride vitamins, allantoins, etc.
- bactericides such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; pyrophosphates, polyphosphates, hexametaphosphate Calcium preventive agents such as zeolite, blood circulation promoters such as vitamin E, amino acids such as alanine, glycine and proline; plant extracts such as rosemary and birch.
- the compounding quantity of a medicinal ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.
- inorganic compounds such as titanium mica, titanium oxide, bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, glucomannan; polyvinyl acetate, acrylic resin Synthetic polymers such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.
- Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method, and used as samples, and evaluated by the methods shown in (1) to (3) below. Furthermore, the composition shown in Table 3 was also evaluated by the method shown in (4) below. The results are shown in the table.
- ⁇ Evaluation method> No dripping About the degree of dripping (dropping of liquid or foam) from the mouth when a specialized panelist (subjects, 3 people) took 1g sample on toothbrush and brushed for 3 minutes Judgment was made using the following criteria. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria. Rating criteria 4 points: The sample did not sag from the mouth even after 3 minutes passed from the start of brushing. 3 points: The sample slid from the mouth within 2 minutes after 2 minutes after the start of brushing. The sample dropped from the mouth within 2 minutes after 1 minute. 1 point: The sample dropped from the mouth within 1 minute after starting brushing. Evaluation criteria ⁇ : More than 3.5 points ⁇ : Over 2.0 points Less than 3.5 points ⁇ : 2.0 points or less
- Dispersibility in the oral cavity Special panelists (subjects, 3 persons) take a 1g sample on a toothbrush, and determine the dispersibility of the paste in the oral cavity after starting toothbrushing using the following criteria. did. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria. Rating criteria 4 points: Dispersibility of the paste was very good 3 points: Dispersibility of the paste was quite good 2 points: Dispersibility of the paste was slightly good 1 point: Dispersibility of the paste was not good Evaluation criteria A: 3. 0 or more ⁇ : 2.5 or more and less than 3.0 ⁇ ⁇ : less than 2.5
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Abstract
This dentifrice composition includes: (A) 1.4-2.5 mass% of an anionic surfactant; (B) 1.4-2.5 mass% of xanthan gum; and (C) 0.1-5 mass% of hydrogen carbonate. The dentifrice composition also includes (D) 0.1-1 mass% of at least one substance selected from sodium polyacrylate and sodium alginate. According to the present invention, a dentifrice composition can be provided which inhibits the dripping of liquid from the mouth during tooth brushing, imparts a clean sensation, and exhibits an excellent feeling when used.
Description
本発明は、歯磨き時の口からの液垂れが防止され、サッパリ感も与え、使用感が優れる歯磨剤組成物に関する。
The present invention relates to a dentifrice composition that prevents dripping from the mouth when brushing teeth, provides a refreshing feeling, and is excellent in use feeling.
口腔用組成物、特に歯磨剤組成物の使用感のうちで、口から泡が垂れたり液が垂れるといった製剤の液垂れは、その使用効果を低下させるだけでなく不快な使用感として認知されやすいものであり、また、歯磨き後に口内がきれいに清掃されてサッパリしたという効果実感を与えることも、重要である。
Among the feelings of use of oral compositions, especially dentifrice compositions, dripping of preparations such as dripping foam or dripping from the mouth not only reduces its effectiveness but is also easily recognized as an unpleasant feeling of use. It is also important to give an actual feeling that the mouth has been cleaned and refreshed after brushing.
歯磨剤組成物には、通常、研磨剤、界面活性剤、湿潤剤、粘結剤等が配合され、界面活性剤としてアニオン性界面活性剤等が泡立ち、清掃性等の確保のために用いられ、また、粘結剤として様々な水溶性高分子物質が適正な粘度、保型性等を保つ目的で用いられている。しかし、歯磨剤組成物を使用して歯磨き(歯磨き時間は通常、3分間程度)していると、開始時には泡が口から垂れ出すことなく歯磨きすることができても、時間が経過するにつれて次第に泡が口から垂れ出して液垂れが生じることがあり、液垂れを防いで磨き心地がよく満足な使用感を有する歯磨剤組成物を得るには改善の余地があった。
A dentifrice composition usually contains a polishing agent, a surfactant, a wetting agent, a binder, and the like, and an anionic surfactant is foamed as a surfactant, and is used for ensuring cleaning properties and the like. In addition, various water-soluble polymer substances are used as binders for the purpose of maintaining proper viscosity and shape retention. However, if you brush your teeth with a dentifrice composition (the toothbrushing time is usually about 3 minutes), you can brush your teeth without dripping from the mouth at the start, but as time passes, Foam may spill out of the mouth and liquid dripping may occur, and there is room for improvement in obtaining a dentifrice composition that prevents dripping and is comfortable to polish and has a satisfactory feeling of use.
一方、歯磨剤等の口腔用組成物用の配合成分として炭酸水素ナトリウム等の炭酸塩は各種用途に用いられており、具体的に炭酸水素塩の配合に関する技術は、特許文献1~7に提案されている。
On the other hand, carbonates such as sodium hydrogen carbonate are used in various applications as a compounding ingredient for oral compositions such as dentifrices. Specifically, techniques relating to the compounding of hydrogen carbonate are proposed in Patent Documents 1 to 7. Has been.
本発明は上記事情に鑑みなされたもので、歯磨き時の口からの液垂れを防止し、サッパリ感も与え、使用感が優れる歯磨剤組成物を提供することを目的とする。
The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition that prevents dripping from the mouth when brushing teeth, gives a refreshing feeling, and is excellent in use feeling.
本発明者らは、上記目的を達成するため鋭意検討を行った結果、歯磨剤組成物にアニオン性界面活性剤を特定量以上配合し、かつキサンタンガムを特定量以上配合し、更に炭酸水素塩を特定量以下で配合すると、歯磨き時に口から泡や液が垂れて液垂れするのを防止し、かつサッパリ感を満足に与え、刺激を適度に抑えることもでき、これにより、優れた使用感を付与できることを知見し、本発明をなすに至った。
また、本発明では、ポリアクリル酸ナトリウム又はアルギン酸ナトリウムを更に配合すると、口腔内での製剤の分散性も改善し、使用感がより向上することも知見した。 As a result of intensive studies to achieve the above object, the present inventors have formulated a specific amount or more of an anionic surfactant in a dentifrice composition, blended a specific amount or more of xanthan gum, and further added a bicarbonate. When blended at a specific amount or less, it prevents foam or liquid from dripping from the mouth when brushing teeth, gives a refreshing feeling satisfactorily, and can suppress irritation moderately. It has been found that it can be imparted, and has led to the present invention.
Moreover, in this invention, when polyacrylic acid sodium or sodium alginate was further mix | blended, it also discovered that the dispersibility of the formulation in an oral cavity also improved and a usability | use_condition improves more.
また、本発明では、ポリアクリル酸ナトリウム又はアルギン酸ナトリウムを更に配合すると、口腔内での製剤の分散性も改善し、使用感がより向上することも知見した。 As a result of intensive studies to achieve the above object, the present inventors have formulated a specific amount or more of an anionic surfactant in a dentifrice composition, blended a specific amount or more of xanthan gum, and further added a bicarbonate. When blended at a specific amount or less, it prevents foam or liquid from dripping from the mouth when brushing teeth, gives a refreshing feeling satisfactorily, and can suppress irritation moderately. It has been found that it can be imparted, and has led to the present invention.
Moreover, in this invention, when polyacrylic acid sodium or sodium alginate was further mix | blended, it also discovered that the dispersibility of the formulation in an oral cavity also improved and a usability | use_condition improves more.
即ち、本発明では、(A)アニオン性界面活性剤1.4~2.5質量%と、(B)キサンタンガム1.4~2.5質量%と、(C)炭酸水素塩0.1~5質量%とを組み合わせて配合し、特に(B)キサンタンガムを比較的多く使用することによって、泡性能が改善し、歯磨き時の液垂れを防止でき、同時に満足なサッパリ感を付与し、刺激を抑制することもできる。
この場合、歯磨剤組成物の使用感を改善するため、泡立ちを向上させることを目的として(A)アニオン性界面活性剤を比較的多い量で配合すると、泡立ちは向上できても、歯磨きを開始してまもなく口から泡が垂れ出して液垂れしてしまう場合があるが、(B)キサンタンガムを特定量以上で併用して配合することによって、歯磨き時の口からの液垂れを効果的に防止し、長時間に亘って持続的に防ぐこともできた。しかし、この場合、(A)及び(B)成分の併用によって、歯磨き時に口をすすいだ後のサッパリ感が損なわれて使用感が低下してしまうという別の問題が生じた。そこで、更に検討を進めたところ、(C)炭酸水素塩を特定量以下で添加することで、前記のようにサッパリ感低下の問題を生じさせることなく液垂れを防止することができた。なお、炭酸水素塩には使用感改善作用があるものの、(A)成分を特定量以上配合し、かつ炭酸水素塩を多く配合し過ぎると刺激が強くなるが、(A)、(B)及び(C)成分の三者をそれぞれ特定量で組み合わせることによって、意外にも、液垂れの防止及びサッパリ感の付与が両立して使用感が向上し、格別な作用効果を付与できた。
歯磨剤組成物では、粘結剤として曳糸性に影響するおそれがあるキサンタンガムは1質量%に満たない量で使用されることが多いが、本発明では、キサンタンガムを1.4質量%以上使用することで、予想外に上述のような作用効果を奏した。
後述の実施例にも示すように、本発明の(A)、(B)及び(C)成分を配合した歯磨剤組成物は、歯磨き開始後1分、更には2分を超えて経過しても口からの液垂れが抑えられ、液垂れのなさが優れ、また、サッパリ感及び刺激のなさも優れた。これに対して、比較例に示すように(A)、(B)及び(C)成分のいずれかを欠く場合、あるいは三者が配合されていてもいずれかの配合量が不適切な場合は、本発明の作用効果が劣った。 That is, in the present invention, (A) 1.4 to 2.5% by mass of an anionic surfactant, (B) 1.4 to 2.5% by mass of xanthan gum, and (C) 0.1 to In combination with 5% by mass, especially by using a relatively large amount of (B) xanthan gum, foam performance can be improved, dripping at the time of tooth brushing can be prevented, and at the same time a satisfactory refreshing feeling can be imparted. It can also be suppressed.
In this case, in order to improve the feeling of use of the dentifrice composition, if (A) an anionic surfactant is blended in a relatively large amount for the purpose of improving foaming, toothbrushing is started even if foaming can be improved. Soon, bubbles may spill out of the mouth and dripping, but (B) Xanthan gum can be used in combination with more than a certain amount to effectively prevent dripping from the mouth when brushing teeth. However, it was possible to prevent it continuously for a long time. However, in this case, the combined use of the components (A) and (B) causes another problem that the feeling of use after rinsing the mouth during brushing is impaired and the feeling of use is lowered. As a result of further investigations, it was possible to prevent dripping without causing a problem of reduced refreshing feeling as described above by adding (C) a hydrogen carbonate in a specific amount or less. Although bicarbonate has an effect of improving the feeling of use, when (A) component is blended more than a specific amount and too much bicarbonate is blended, irritation becomes strong, but (A), (B) and By combining each of the three components (C) in specific amounts, surprisingly both the prevention of dripping and the provision of a refreshing feeling can be achieved, and the feeling of use can be improved, and an exceptional effect can be imparted.
In dentifrice compositions, xanthan gum that may affect spinnability as a binder is often used in an amount of less than 1% by mass, but in the present invention, xanthan gum is used in an amount of 1.4% by mass or more. As a result, the above-mentioned effects were unexpectedly achieved.
As shown also in the below-mentioned Example, the dentifrice composition which mix | blended (A), (B) and (C) component of this invention is 1 minute after the start of toothpaste, Furthermore, more than 2 minutes passed. In addition, the dripping from the mouth was suppressed, the dripping was excellent, and the refreshing feeling and lack of irritation were also excellent. On the other hand, as shown in the comparative example, when any of the components (A), (B) and (C) is missing, or when any of the three components is blended, the blending amount is inappropriate. The effect of the present invention was inferior.
この場合、歯磨剤組成物の使用感を改善するため、泡立ちを向上させることを目的として(A)アニオン性界面活性剤を比較的多い量で配合すると、泡立ちは向上できても、歯磨きを開始してまもなく口から泡が垂れ出して液垂れしてしまう場合があるが、(B)キサンタンガムを特定量以上で併用して配合することによって、歯磨き時の口からの液垂れを効果的に防止し、長時間に亘って持続的に防ぐこともできた。しかし、この場合、(A)及び(B)成分の併用によって、歯磨き時に口をすすいだ後のサッパリ感が損なわれて使用感が低下してしまうという別の問題が生じた。そこで、更に検討を進めたところ、(C)炭酸水素塩を特定量以下で添加することで、前記のようにサッパリ感低下の問題を生じさせることなく液垂れを防止することができた。なお、炭酸水素塩には使用感改善作用があるものの、(A)成分を特定量以上配合し、かつ炭酸水素塩を多く配合し過ぎると刺激が強くなるが、(A)、(B)及び(C)成分の三者をそれぞれ特定量で組み合わせることによって、意外にも、液垂れの防止及びサッパリ感の付与が両立して使用感が向上し、格別な作用効果を付与できた。
歯磨剤組成物では、粘結剤として曳糸性に影響するおそれがあるキサンタンガムは1質量%に満たない量で使用されることが多いが、本発明では、キサンタンガムを1.4質量%以上使用することで、予想外に上述のような作用効果を奏した。
後述の実施例にも示すように、本発明の(A)、(B)及び(C)成分を配合した歯磨剤組成物は、歯磨き開始後1分、更には2分を超えて経過しても口からの液垂れが抑えられ、液垂れのなさが優れ、また、サッパリ感及び刺激のなさも優れた。これに対して、比較例に示すように(A)、(B)及び(C)成分のいずれかを欠く場合、あるいは三者が配合されていてもいずれかの配合量が不適切な場合は、本発明の作用効果が劣った。 That is, in the present invention, (A) 1.4 to 2.5% by mass of an anionic surfactant, (B) 1.4 to 2.5% by mass of xanthan gum, and (C) 0.1 to In combination with 5% by mass, especially by using a relatively large amount of (B) xanthan gum, foam performance can be improved, dripping at the time of tooth brushing can be prevented, and at the same time a satisfactory refreshing feeling can be imparted. It can also be suppressed.
In this case, in order to improve the feeling of use of the dentifrice composition, if (A) an anionic surfactant is blended in a relatively large amount for the purpose of improving foaming, toothbrushing is started even if foaming can be improved. Soon, bubbles may spill out of the mouth and dripping, but (B) Xanthan gum can be used in combination with more than a certain amount to effectively prevent dripping from the mouth when brushing teeth. However, it was possible to prevent it continuously for a long time. However, in this case, the combined use of the components (A) and (B) causes another problem that the feeling of use after rinsing the mouth during brushing is impaired and the feeling of use is lowered. As a result of further investigations, it was possible to prevent dripping without causing a problem of reduced refreshing feeling as described above by adding (C) a hydrogen carbonate in a specific amount or less. Although bicarbonate has an effect of improving the feeling of use, when (A) component is blended more than a specific amount and too much bicarbonate is blended, irritation becomes strong, but (A), (B) and By combining each of the three components (C) in specific amounts, surprisingly both the prevention of dripping and the provision of a refreshing feeling can be achieved, and the feeling of use can be improved, and an exceptional effect can be imparted.
In dentifrice compositions, xanthan gum that may affect spinnability as a binder is often used in an amount of less than 1% by mass, but in the present invention, xanthan gum is used in an amount of 1.4% by mass or more. As a result, the above-mentioned effects were unexpectedly achieved.
As shown also in the below-mentioned Example, the dentifrice composition which mix | blended (A), (B) and (C) component of this invention is 1 minute after the start of toothpaste, Furthermore, more than 2 minutes passed. In addition, the dripping from the mouth was suppressed, the dripping was excellent, and the refreshing feeling and lack of irritation were also excellent. On the other hand, as shown in the comparative example, when any of the components (A), (B) and (C) is missing, or when any of the three components is blended, the blending amount is inappropriate. The effect of the present invention was inferior.
従って、本発明は、下記の歯磨剤組成物を提供する。
〔1〕
(A)アニオン性界面活性剤 1.4~2.5質量%、
(B)キサンタンガム 1.4~2.5質量%、
及び
(C)炭酸水素塩 0.1~5質量%
を含有する歯磨剤組成物。
〔2〕
(A)成分が、スルホン酸基を含有するアニオン性界面活性剤である〔1〕に記載の歯磨剤組成物。
〔3〕
(C)炭酸水素塩が炭酸水素ナトリウムであり、その含有量が0.1~3質量%である〔1〕又は〔2〕に記載の歯磨剤組成物。
〔4〕
(A)/(B)が質量比として0.7~1.7である〔1〕~〔3〕のいずれかに記載の歯磨剤組成物。
〔5〕
更に、(D)ポリアクリル酸ナトリウム及びアルギン酸ナトリウムから選ばれる1種以上を0.1~1質量%含有する〔1〕~〔4〕のいずれかに記載の歯磨剤組成物。
〔6〕
(B)/(D)が質量比として1.5~20である〔5〕に記載の歯磨剤組成物。
〔7〕
更に、(E)研磨剤を8~70質量%含有する〔1〕~〔6〕のいずれかに記載の歯磨剤組成物。 Accordingly, the present invention provides the following dentifrice composition.
[1]
(A) anionic surfactant 1.4-2.5% by mass,
(B) xanthan gum 1.4-2.5% by mass,
And (C) bicarbonate 0.1 to 5% by mass
A dentifrice composition containing
[2]
(A) Dentifrice composition as described in [1] whose component is an anionic surfactant containing a sulfonic acid group.
[3]
(C) The dentifrice composition according to [1] or [2], wherein the bicarbonate is sodium bicarbonate and the content thereof is 0.1 to 3% by mass.
[4]
The dentifrice composition according to any one of [1] to [3], wherein (A) / (B) is 0.7 to 1.7 in terms of mass ratio.
[5]
(D) The dentifrice composition according to any one of [1] to [4], further comprising 0.1 to 1% by mass of one or more selected from sodium polyacrylate and sodium alginate.
[6]
The dentifrice composition according to [5], wherein (B) / (D) is 1.5 to 20 in terms of mass ratio.
[7]
(E) The dentifrice composition according to any one of [1] to [6], further comprising 8 to 70% by mass of an abrasive.
〔1〕
(A)アニオン性界面活性剤 1.4~2.5質量%、
(B)キサンタンガム 1.4~2.5質量%、
及び
(C)炭酸水素塩 0.1~5質量%
を含有する歯磨剤組成物。
〔2〕
(A)成分が、スルホン酸基を含有するアニオン性界面活性剤である〔1〕に記載の歯磨剤組成物。
〔3〕
(C)炭酸水素塩が炭酸水素ナトリウムであり、その含有量が0.1~3質量%である〔1〕又は〔2〕に記載の歯磨剤組成物。
〔4〕
(A)/(B)が質量比として0.7~1.7である〔1〕~〔3〕のいずれかに記載の歯磨剤組成物。
〔5〕
更に、(D)ポリアクリル酸ナトリウム及びアルギン酸ナトリウムから選ばれる1種以上を0.1~1質量%含有する〔1〕~〔4〕のいずれかに記載の歯磨剤組成物。
〔6〕
(B)/(D)が質量比として1.5~20である〔5〕に記載の歯磨剤組成物。
〔7〕
更に、(E)研磨剤を8~70質量%含有する〔1〕~〔6〕のいずれかに記載の歯磨剤組成物。 Accordingly, the present invention provides the following dentifrice composition.
[1]
(A) anionic surfactant 1.4-2.5% by mass,
(B) xanthan gum 1.4-2.5% by mass,
And (C) bicarbonate 0.1 to 5% by mass
A dentifrice composition containing
[2]
(A) Dentifrice composition as described in [1] whose component is an anionic surfactant containing a sulfonic acid group.
[3]
(C) The dentifrice composition according to [1] or [2], wherein the bicarbonate is sodium bicarbonate and the content thereof is 0.1 to 3% by mass.
[4]
The dentifrice composition according to any one of [1] to [3], wherein (A) / (B) is 0.7 to 1.7 in terms of mass ratio.
[5]
(D) The dentifrice composition according to any one of [1] to [4], further comprising 0.1 to 1% by mass of one or more selected from sodium polyacrylate and sodium alginate.
[6]
The dentifrice composition according to [5], wherein (B) / (D) is 1.5 to 20 in terms of mass ratio.
[7]
(E) The dentifrice composition according to any one of [1] to [6], further comprising 8 to 70% by mass of an abrasive.
本発明によれば、歯磨き時の口からの液垂れを防止し、サッパリ感も与え、使用感が優れる歯磨剤組成物を提供できる。
According to the present invention, it is possible to provide a dentifrice composition that prevents dripping from the mouth during tooth brushing, gives a refreshing feeling, and is excellent in use feeling.
以下、本発明につき更に詳述する。本発明の歯磨剤組成物は、(A)アニオン性界面活性剤、(B)キサンタンガム及び(C)炭酸水素塩をそれぞれ特定量で含有する。
Hereinafter, the present invention will be described in further detail. The dentifrice composition of the present invention contains (A) an anionic surfactant, (B) xanthan gum, and (C) a bicarbonate in specific amounts.
(A)アニオン性界面活性剤としては、アルキル硫酸塩、α-オレフィンスルホン酸塩、水素添加ココナッツ脂肪酸モノグリセリドモノ硫酸塩、ラウリルスルホ酢酸塩、N-メチル-N-アシルタウリン塩等のN-アシルタウレート、アシルサルコシン塩、N-アシル-L-グルタミン酸塩等のアシルアミノ酸塩が挙げられる。これらは1種又は2種以上で使用できる。中でも、泡立ちの点で、スルホン酸基を含有するアニオン性界面活性剤が好ましく、より好ましくはアルキル硫酸塩、α-オレフィンスルホン酸塩である。前記塩としては、ナトリウム塩、カリウム塩、アンモニウム塩等が挙げられ、特にナトリウム塩が好ましい。
アルキル硫酸塩は、アルキル基の炭素数が好ましくは10~14であり、具体的には、アルキル硫酸塩としてラウリル硫酸ナトリウム、ミリストイル硫酸ナトリウムが挙げられる。
α-オレフィンスルホン酸塩としては、炭素数が14~16のα-オレフィンスルホン酸のナトリウム、カリウム等のアルカリ金属塩を用いることができ、中でも炭素数14のα-オレフィンスルホン酸塩、特にナトリウム塩(一般名;テトラデセンスルホン酸ナトリウム)が好ましい。これらは口腔用製剤に使用可能な市販品を入手することができ、例えばライオン・スペシャリティ・ケミカルズ(株)製の商品名「KリポランPJ-400CJ」を使用し得る。 (A) Anionic surfactants include N-acyl such as alkyl sulfate, α-olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-methyl-N-acyl taurate, etc. Examples include acyl amino acid salts such as taurate, acyl sarcosine salts, and N-acyl-L-glutamate. These can be used alone or in combination of two or more. Among these, anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of foaming, and alkyl sulfates and α-olefin sulfonates are more preferable. Examples of the salt include sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.
In the alkyl sulfate, the alkyl group preferably has 10 to 14 carbon atoms. Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
As the α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonate having 14 to 16 carbon atoms can be used, and among them, α-olefin sulfonate having 14 carbon atoms, particularly sodium. Salts (generic name; sodium tetradecene sulfonate) are preferred. Commercially available products that can be used for oral preparations can be obtained. For example, “K Liporan PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
アルキル硫酸塩は、アルキル基の炭素数が好ましくは10~14であり、具体的には、アルキル硫酸塩としてラウリル硫酸ナトリウム、ミリストイル硫酸ナトリウムが挙げられる。
α-オレフィンスルホン酸塩としては、炭素数が14~16のα-オレフィンスルホン酸のナトリウム、カリウム等のアルカリ金属塩を用いることができ、中でも炭素数14のα-オレフィンスルホン酸塩、特にナトリウム塩(一般名;テトラデセンスルホン酸ナトリウム)が好ましい。これらは口腔用製剤に使用可能な市販品を入手することができ、例えばライオン・スペシャリティ・ケミカルズ(株)製の商品名「KリポランPJ-400CJ」を使用し得る。 (A) Anionic surfactants include N-acyl such as alkyl sulfate, α-olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-methyl-N-acyl taurate, etc. Examples include acyl amino acid salts such as taurate, acyl sarcosine salts, and N-acyl-L-glutamate. These can be used alone or in combination of two or more. Among these, anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of foaming, and alkyl sulfates and α-olefin sulfonates are more preferable. Examples of the salt include sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.
In the alkyl sulfate, the alkyl group preferably has 10 to 14 carbon atoms. Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
As the α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonate having 14 to 16 carbon atoms can be used, and among them, α-olefin sulfonate having 14 carbon atoms, particularly sodium. Salts (generic name; sodium tetradecene sulfonate) are preferred. Commercially available products that can be used for oral preparations can be obtained. For example, “K Liporan PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
なお、スルホン酸基を持たないアニオン性界面活性剤、特にN-アシル-L-グルタミン酸塩等のアシルアミノ酸塩は、(B)及び(C)成分と組み合わせることによって泡立ちが弱いことがあり、この点でも、(A)成分としてスルホン酸基を含有するアニオン性界面活性剤、とりわけアルキル硫酸塩及びα-オレフィンスルホン酸塩が好適である。
In addition, anionic surfactants having no sulfonic acid group, particularly acyl amino acid salts such as N-acyl-L-glutamate, may have weak foaming when combined with the components (B) and (C). Also in this respect, anionic surfactants containing a sulfonic acid group as the component (A), particularly alkyl sulfates and α-olefin sulfonates are preferred.
(A)アニオン性界面活性剤の配合量は、組成物全体の1.4~2.5%(質量%、以下同様)であり、好ましくは1.6~2.0%である。配合量が1.4%未満であると、泡立ちが低下し、液垂れのなさが劣ったり、サッパリ感が劣る。2.5%を超えると、刺激が強くなる。なお、上述したアニオン性界面活性剤のそれぞれの配合量範囲も上記と同様でよい。
(A) The compounding amount of the anionic surfactant is 1.4 to 2.5% (mass%, the same applies hereinafter) of the whole composition, and preferably 1.6 to 2.0%. If the blending amount is less than 1.4%, foaming is reduced, the lack of dripping is inferior, and the refreshing feeling is inferior. When it exceeds 2.5%, the stimulation becomes stronger. In addition, each compounding quantity range of the anionic surfactant mentioned above may be the same as the above.
(B)キサンタンガムの配合量は、組成物全体の1.4~2.5%であり、好ましくは1.5~2.0%、より好ましくは1.6~2.0%である。配合量が1.4%未満であると、液垂れを持続的に防止できず、液垂れのなさが劣る。2.5%を超えると、サッパリ感が低下する。また、製剤が固くなり過ぎて使用性が悪くなる。
(B) The compounding amount of xanthan gum is 1.4 to 2.5% of the total composition, preferably 1.5 to 2.0%, more preferably 1.6 to 2.0%. If the blending amount is less than 1.4%, dripping cannot be prevented continuously, and the lack of dripping is inferior. When it exceeds 2.5%, the refreshing feeling is lowered. In addition, the preparation becomes too hard and the usability deteriorates.
(A)アニオン性界面活性剤と(B)キサンタンガムとの配合割合を示す(A)/(B)は、質量比として0.7~1.7が好ましく、より好ましくは0.9~1.3である。この範囲内であると、液垂れをより防止し、また、サッパリ感をより改善し、刺激をより抑えることもできる。0.7未満であると、サッパリ感が不足する場合があり、1.7を超えると、液垂れを十分に防止できなかったり、刺激が強くなる場合がある。
(A) / (B) showing the blending ratio of (A) anionic surfactant and (B) xanthan gum is preferably 0.7 to 1.7, more preferably 0.9 to 1. 3. Within this range, dripping can be further prevented, a refreshing feeling can be further improved, and stimulation can be further suppressed. If it is less than 0.7, the refreshing feeling may be insufficient, and if it exceeds 1.7, dripping may not be sufficiently prevented or irritation may be increased.
(C)炭酸水素塩としては、炭酸水素ナトリウムを使用し得る。
(C)炭酸水素塩の配合量は、組成物全体の0.1~5%であり、好ましくは0.1~3%、より好ましくは0.3~2%、更に好ましくは0.3~1%である。0.1%未満であると、サッパリ感が不足し、5%を超えると、刺激や違和感が強くなり、また、液垂れを十分に防止できなくなることがある。 (C) Sodium bicarbonate can be used as the bicarbonate.
The blending amount of (C) bicarbonate is 0.1 to 5% of the entire composition, preferably 0.1 to 3%, more preferably 0.3 to 2%, and still more preferably 0.3 to 1%. If it is less than 0.1%, the feeling of refreshing is insufficient, and if it exceeds 5%, irritation and discomfort may become strong, and dripping may not be sufficiently prevented.
(C)炭酸水素塩の配合量は、組成物全体の0.1~5%であり、好ましくは0.1~3%、より好ましくは0.3~2%、更に好ましくは0.3~1%である。0.1%未満であると、サッパリ感が不足し、5%を超えると、刺激や違和感が強くなり、また、液垂れを十分に防止できなくなることがある。 (C) Sodium bicarbonate can be used as the bicarbonate.
The blending amount of (C) bicarbonate is 0.1 to 5% of the entire composition, preferably 0.1 to 3%, more preferably 0.3 to 2%, and still more preferably 0.3 to 1%. If it is less than 0.1%, the feeling of refreshing is insufficient, and if it exceeds 5%, irritation and discomfort may become strong, and dripping may not be sufficiently prevented.
本発明では、更に(D)ポリアクリル酸ナトリウム及び/又はアルギン酸ナトリウムを配合することが好ましい。(D)成分を配合すると、歯磨剤組成物の口腔内での分散性が向上し、使用性がより高まる。
(D)成分は、ポリアクリル酸ナトリウム、アルギン酸ナトリウムのいずれかであってもよいが、効果発現の点で両者を併用してもよい。
(D)成分の配合量は、組成物全体の0.1~1%が好ましく、より好ましくは0.3~1%である。0.1%以上であると、口腔内分散性が十分に向上する。1%を超えると、製剤が固くなり過ぎる場合がある。 In the present invention, it is preferable to further blend (D) sodium polyacrylate and / or sodium alginate. When (D) component is mix | blended, the dispersibility in the oral cavity of a dentifrice composition will improve, and the usability will increase more.
The component (D) may be either sodium polyacrylate or sodium alginate, but both may be used together in terms of effect.
The blending amount of component (D) is preferably 0.1 to 1%, more preferably 0.3 to 1% of the entire composition. If it is 0.1% or more, dispersibility in the oral cavity is sufficiently improved. If it exceeds 1%, the preparation may become too hard.
(D)成分は、ポリアクリル酸ナトリウム、アルギン酸ナトリウムのいずれかであってもよいが、効果発現の点で両者を併用してもよい。
(D)成分の配合量は、組成物全体の0.1~1%が好ましく、より好ましくは0.3~1%である。0.1%以上であると、口腔内分散性が十分に向上する。1%を超えると、製剤が固くなり過ぎる場合がある。 In the present invention, it is preferable to further blend (D) sodium polyacrylate and / or sodium alginate. When (D) component is mix | blended, the dispersibility in the oral cavity of a dentifrice composition will improve, and the usability will increase more.
The component (D) may be either sodium polyacrylate or sodium alginate, but both may be used together in terms of effect.
The blending amount of component (D) is preferably 0.1 to 1%, more preferably 0.3 to 1% of the entire composition. If it is 0.1% or more, dispersibility in the oral cavity is sufficiently improved. If it exceeds 1%, the preparation may become too hard.
(B)キサンタンガムと(D)ポリアクリル酸ナトリウム及び/又はアルギン酸ナトリウムとの配合割合を示す(B)/(D)は、質量比として1.5~20が好ましく、より好ましくは1.6~16、更に好ましくは2~10である。この範囲内であると、口腔内分散性がより向上し、また、製剤固さの適度な維持にも好適である。
(B) / (D) indicating the blending ratio of (B) xanthan gum and (D) sodium polyacrylate and / or sodium alginate is preferably 1.5 to 20, more preferably 1.6 to 16, more preferably 2 to 10. Within this range, dispersibility in the oral cavity is further improved, and it is also suitable for appropriate maintenance of formulation hardness.
本発明の歯磨剤組成物は、更に、(E)研磨剤を配合できる。
研磨剤としては、第2リン酸カルシウム・2水和塩又は無水和物、第1リン酸カルシウム、第3リン酸カルシウム、ピロリン酸カルシウム等のリン酸カルシウム系研磨剤;沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のシリカ系研磨剤;炭酸カルシウム等の炭酸カルシウム系研磨剤や、水酸化カルシウム、水酸化アルミニウム、第3リン酸マグネシウム、炭酸マグネシウム、硫酸カルシウム、ベントナイト、ハイドロキシアパタイト等の研磨粒子が挙げられ、これらの1種又は2種以上を配合できる。これらの中では、特に沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のケイ酸塩を主成分とするシリカ系研磨剤や炭酸カルシウム系研磨剤、とりわけ沈降性シリカ等のシリカ系研磨剤が好ましい。
シリカ系研磨剤としては、市販品を使用でき、例えば、HUBER社製のZeodent124、Zeodent113、Rhodia社製のTIXOSIL 73、TIXOSIL 63、Degussa社製のSident 3、Sident 20、多木化学(株)製のジルコノシリケート、アルミノシリケートなどが挙げられる。
研磨剤の配合量は、組成物全体の8~70%、特に10~50%が好ましい。 The dentifrice composition of the present invention can further contain (E) an abrasive.
As abrasives, calcium phosphate abrasives such as dicalcium phosphate dihydrate or anhydrous, primary calcium phosphate, tertiary calcium phosphate, calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-binding silica Silica-based abrasives such as calcium carbonate-based abrasives such as calcium carbonate, and abrasive particles such as calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, etc. These 1 type (s) or 2 or more types can be mix | blended. Among these, silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, especially silica-based materials such as precipitated silica. Abrasives are preferred.
Commercially available products can be used as the silica-based abrasive, such as Zeodent 124 and Zedent 113 manufactured by HUBER, TIXOSIL 73 and TIXOSIL 63 manufactured by Rhodia, Sident 3 and Sident 20 manufactured by Degussa, and manufactured by Taki Chemical Co., Ltd. Zirconosilicate, aluminosilicate and the like.
The blending amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the whole composition.
研磨剤としては、第2リン酸カルシウム・2水和塩又は無水和物、第1リン酸カルシウム、第3リン酸カルシウム、ピロリン酸カルシウム等のリン酸カルシウム系研磨剤;沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のシリカ系研磨剤;炭酸カルシウム等の炭酸カルシウム系研磨剤や、水酸化カルシウム、水酸化アルミニウム、第3リン酸マグネシウム、炭酸マグネシウム、硫酸カルシウム、ベントナイト、ハイドロキシアパタイト等の研磨粒子が挙げられ、これらの1種又は2種以上を配合できる。これらの中では、特に沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のケイ酸塩を主成分とするシリカ系研磨剤や炭酸カルシウム系研磨剤、とりわけ沈降性シリカ等のシリカ系研磨剤が好ましい。
シリカ系研磨剤としては、市販品を使用でき、例えば、HUBER社製のZeodent124、Zeodent113、Rhodia社製のTIXOSIL 73、TIXOSIL 63、Degussa社製のSident 3、Sident 20、多木化学(株)製のジルコノシリケート、アルミノシリケートなどが挙げられる。
研磨剤の配合量は、組成物全体の8~70%、特に10~50%が好ましい。 The dentifrice composition of the present invention can further contain (E) an abrasive.
As abrasives, calcium phosphate abrasives such as dicalcium phosphate dihydrate or anhydrous, primary calcium phosphate, tertiary calcium phosphate, calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-binding silica Silica-based abrasives such as calcium carbonate-based abrasives such as calcium carbonate, and abrasive particles such as calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, etc. These 1 type (s) or 2 or more types can be mix | blended. Among these, silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, especially silica-based materials such as precipitated silica. Abrasives are preferred.
Commercially available products can be used as the silica-based abrasive, such as Zeodent 124 and Zedent 113 manufactured by HUBER, TIXOSIL 73 and TIXOSIL 63 manufactured by Rhodia, Sident 3 and Sident 20 manufactured by Degussa, and manufactured by Taki Chemical Co., Ltd. Zirconosilicate, aluminosilicate and the like.
The blending amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the whole composition.
また、研磨剤は顆粒状であってもよく、研磨性を有する成分として、顆粒を配合できる。顆粒としては、水不溶性粉体を顆粒状に形成させた粒子であり、粒状化には結合剤を用いた造粒物でもよい。
水不溶性粉体としては、第二リン酸カルシウム、第三リン酸カルシウム、水不溶性メタリン酸カルシウム、シリカ、水酸化アルミニウム、リン酸マグネシウム、ベンガラ、炭酸カルシウム、ピロリン酸カルシウム、ゼオライト、アルミノ珪酸塩、炭酸マグネシウム、ジルコノシリケート、硫酸カルシウム等の無機粉体やこれらの混合物が挙げられ、特にシリカ顆粒、ゼオライト顆粒が好適である。
研磨剤は、上述の研磨粒子と顆粒を併用してもよい。 The abrasive may be granular, and granules can be blended as an abrasive component. The granule is a particle in which a water-insoluble powder is formed into a granule, and a granulated product using a binder may be used for granulation.
As water-insoluble powder, dicalcium phosphate, tricalcium phosphate, water-insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, bengara, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, zirconosilicate Inorganic powders such as calcium sulfate and mixtures thereof can be mentioned, and silica granules and zeolite granules are particularly suitable.
As the abrasive, the above-described abrasive particles and granules may be used in combination.
水不溶性粉体としては、第二リン酸カルシウム、第三リン酸カルシウム、水不溶性メタリン酸カルシウム、シリカ、水酸化アルミニウム、リン酸マグネシウム、ベンガラ、炭酸カルシウム、ピロリン酸カルシウム、ゼオライト、アルミノ珪酸塩、炭酸マグネシウム、ジルコノシリケート、硫酸カルシウム等の無機粉体やこれらの混合物が挙げられ、特にシリカ顆粒、ゼオライト顆粒が好適である。
研磨剤は、上述の研磨粒子と顆粒を併用してもよい。 The abrasive may be granular, and granules can be blended as an abrasive component. The granule is a particle in which a water-insoluble powder is formed into a granule, and a granulated product using a binder may be used for granulation.
As water-insoluble powder, dicalcium phosphate, tricalcium phosphate, water-insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, bengara, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, zirconosilicate Inorganic powders such as calcium sulfate and mixtures thereof can be mentioned, and silica granules and zeolite granules are particularly suitable.
As the abrasive, the above-described abrasive particles and granules may be used in combination.
本発明の歯磨剤組成物は、特に練歯磨剤として好適であり、公知の方法で調製できる。また、上記成分に加えて、通常、歯磨剤組成物に使用されている公知成分を、本発明の効果を損なわない範囲で必要に応じて配合できる。前記配合できる任意成分としては、(B)及び(D)成分以外の粘結剤、(A)成分以外の界面活性剤、湿潤剤、甘味剤、香料、pH調整剤、防腐剤、薬効成分等が挙げられる。
The dentifrice composition of the present invention is particularly suitable as a toothpaste and can be prepared by a known method. Moreover, in addition to the said component, the well-known component normally used for the dentifrice composition can be mix | blended as needed in the range which does not impair the effect of this invention. Examples of the optional components that can be blended include binders other than the components (B) and (D), surfactants other than the component (A), wetting agents, sweeteners, fragrances, pH adjusters, preservatives, medicinal components, and the like. Is mentioned.
粘結剤としては、増粘性シリカ、ケイ酸アルミニウム等の無機粘結剤;カルボキシメチルセルロースナトリウム、ポリビニルピロリドン、カラギーナン、メチルセルロース、ヒドロキシエチルセルロースナトリウム、トラガントガム、カラヤガム、アラビヤガム、ローカストビーンガム、ポリビニルアルコール、カルボキシビニルポリマー、カーボポール、ビーガム、アルギン酸プロピレングリコール等の(B)及び(D)成分以外の有機粘結剤を配合してもよい。
Binders include inorganic binders such as thickening silica and aluminum silicate; sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, caraya gum, arabiya gum, locust bean gum, polyvinyl alcohol, carboxyvinyl You may mix | blend organic binders other than (B) and (D) components, such as a polymer, carbopol, bee gum, and propylene glycol alginate.
増粘性シリカとしては、吸液量が2~5ml/gの範囲の公知の製法で得られたシリカを用いることができる。なお、吸液量の測定方法は、下記の通りである。
試料1.0gを清浄なガラス板上に量り取り、ミクロビュレットを用いて、42.5%グリセリンを少量ずつ滴下しながらステンレス製のへらで液が均一になるように試料を混合する。試料が一つの塊となり、へらでガラス板よりきれいに剥がれるようになったときを終点とし、要した液量(ml)を吸液量とする。
このような増粘性シリカとして具体的には、徳山曹達(株)製のTokusil、PQコーポレーション(株)製のSORBOSIL TC15、Rhodia社製のTIXOSIL 43、HUBER社製のZeodent 153、DSLジャパン(株)製のカープレックス #67Qなどの市販品を使用できる。 As the thickening silica, silica obtained by a known production method having a liquid absorption amount of 2 to 5 ml / g can be used. In addition, the measuring method of the amount of liquid absorption is as follows.
Weigh 1.0 g of a sample on a clean glass plate, and mix the sample with a stainless steel spatula using a microburet while dripping 42.5% glycerin little by little. The end point is when the sample becomes one lump and comes off cleanly from the glass plate with a spatula, and the required liquid volume (ml) is the liquid absorption.
Specific examples of such a thickening silica include Tokuyama Soda Co., Ltd. Tokusil, PQ Corporation SORBOSIL TC15, Rhodia TIXOSIL 43, HUBER Zeodent 153, DSL Japan Co., Ltd. Commercially available products such as Carplex # 67Q made by the manufacturer can be used.
試料1.0gを清浄なガラス板上に量り取り、ミクロビュレットを用いて、42.5%グリセリンを少量ずつ滴下しながらステンレス製のへらで液が均一になるように試料を混合する。試料が一つの塊となり、へらでガラス板よりきれいに剥がれるようになったときを終点とし、要した液量(ml)を吸液量とする。
このような増粘性シリカとして具体的には、徳山曹達(株)製のTokusil、PQコーポレーション(株)製のSORBOSIL TC15、Rhodia社製のTIXOSIL 43、HUBER社製のZeodent 153、DSLジャパン(株)製のカープレックス #67Qなどの市販品を使用できる。 As the thickening silica, silica obtained by a known production method having a liquid absorption amount of 2 to 5 ml / g can be used. In addition, the measuring method of the amount of liquid absorption is as follows.
Weigh 1.0 g of a sample on a clean glass plate, and mix the sample with a stainless steel spatula using a microburet while dripping 42.5% glycerin little by little. The end point is when the sample becomes one lump and comes off cleanly from the glass plate with a spatula, and the required liquid volume (ml) is the liquid absorption.
Specific examples of such a thickening silica include Tokuyama Soda Co., Ltd. Tokusil, PQ Corporation SORBOSIL TC15, Rhodia TIXOSIL 43, HUBER Zeodent 153, DSL Japan Co., Ltd. Commercially available products such as Carplex # 67Q made by the manufacturer can be used.
カルボキシメチルセルロースナトリウムとしては、カルボキシメチル基の平均置換度(DS化度)が0.5~1.5のものが好適に使用できる。
カルボキシメチルセルロースナトリウムは、粘度が15~3,000mPa・s(2%水溶液、20℃におけるB型粘度計による測定値、以下同様。)のものが好適である。
なお、上記粘度は、B8H型粘度計(例えば(株)東京計器製)を用い、粘度域に合わせて1~4番のロータを用いて測定した値である。例えば、粘度が100mPa・s未満のときは、1番のロータを用いて50rpmで3分後の粘度を、粘度が100mPa・s以上のときは、1~4番のロータを用いて20rpmで3分後の粘度を測定することができる。
このようなカルボキシメチルセルロースナトリウムとしては、ダイセルファインケム(株)から販売されているCMCダイセル、第一工業製薬(株)製のセロゲン、日本製紙(株)製のサンローズなどの市販品を使用できる。 As sodium carboxymethylcellulose, those having an average substitution degree (DS conversion degree) of carboxymethyl group of 0.5 to 1.5 can be preferably used.
Sodium carboxymethylcellulose having a viscosity of 15 to 3,000 mPa · s (2% aqueous solution, measured with a B-type viscometer at 20 ° C., the same shall apply hereinafter) is preferable.
The viscosity is a value measured using a B8H type viscometer (for example, manufactured by Tokyo Keiki Co., Ltd.) and using a No. 1 to 4 rotor according to the viscosity range. For example, when the viscosity is less than 100 mPa · s, the viscosity after 3 minutes at 50 rpm using the No. 1 rotor is used, and when the viscosity is 100 mPa · s or more, 3 times at 20 rpm using the No. 1 to 4 rotor. The viscosity after minutes can be measured.
As such carboxymethylcellulose sodium, commercially available products such as CMC Daicel sold by Daicel Finechem Co., Ltd., Serogen manufactured by Daiichi Kogyo Seiyaku Co., Ltd., and Sunrose manufactured by Nippon Paper Industries Co., Ltd. can be used.
カルボキシメチルセルロースナトリウムは、粘度が15~3,000mPa・s(2%水溶液、20℃におけるB型粘度計による測定値、以下同様。)のものが好適である。
なお、上記粘度は、B8H型粘度計(例えば(株)東京計器製)を用い、粘度域に合わせて1~4番のロータを用いて測定した値である。例えば、粘度が100mPa・s未満のときは、1番のロータを用いて50rpmで3分後の粘度を、粘度が100mPa・s以上のときは、1~4番のロータを用いて20rpmで3分後の粘度を測定することができる。
このようなカルボキシメチルセルロースナトリウムとしては、ダイセルファインケム(株)から販売されているCMCダイセル、第一工業製薬(株)製のセロゲン、日本製紙(株)製のサンローズなどの市販品を使用できる。 As sodium carboxymethylcellulose, those having an average substitution degree (DS conversion degree) of carboxymethyl group of 0.5 to 1.5 can be preferably used.
Sodium carboxymethylcellulose having a viscosity of 15 to 3,000 mPa · s (2% aqueous solution, measured with a B-type viscometer at 20 ° C., the same shall apply hereinafter) is preferable.
The viscosity is a value measured using a B8H type viscometer (for example, manufactured by Tokyo Keiki Co., Ltd.) and using a No. 1 to 4 rotor according to the viscosity range. For example, when the viscosity is less than 100 mPa · s, the viscosity after 3 minutes at 50 rpm using the No. 1 rotor is used, and when the viscosity is 100 mPa · s or more, 3 times at 20 rpm using the No. 1 to 4 rotor. The viscosity after minutes can be measured.
As such carboxymethylcellulose sodium, commercially available products such as CMC Daicel sold by Daicel Finechem Co., Ltd., Serogen manufactured by Daiichi Kogyo Seiyaku Co., Ltd., and Sunrose manufactured by Nippon Paper Industries Co., Ltd. can be used.
これら粘結剤の配合量としては、無機粘結剤は組成全体の0~10%、好ましくは0.5~10%、より好ましくは1~8%であることが好ましい。また、(B)及び(D)成分以外の有機粘結剤は0~3%であることが好ましい。
The blending amount of these binders is preferably 0 to 10%, preferably 0.5 to 10%, more preferably 1 to 8% of the total composition of the inorganic binder. The organic binder other than the components (B) and (D) is preferably 0 to 3%.
界面活性剤としては、非イオン性界面活性剤、両性界面活性剤が挙げられ、1種単独で又は2種以上を組み合わせて配合できる。
非イオン性界面活性剤としては、ポリオキシエチレン硬化ヒマシ油;ポリオキシエチレン脂肪酸エステル;ポリグリセリン脂肪酸エステル;マルトース脂肪酸エステル等のショ糖脂肪酸エステル;マルチトール脂肪酸エステル、ラクチトール脂肪酸エステル等の糖アルコール脂肪酸エステル;アルキロールアマイド;ポリオキシエチレンソルビタンモノステアレート等のポリオキシエチレンソルビタン脂肪酸エステル;ラウリル酸モノ又はジエタノールアミド等の脂肪酸ジエタノールアミド;ソルビタン脂肪酸エステル;ポリオキシエチレンアルキルエーテル;ポリオキシエチレンポリオキシプロピレン共重合体;ポリオキシエチレンポリオキシプロピレン脂肪酸エステルが挙げられる。非イオン性界面活性剤は、組成物全体の10%以下配合することができ、0%であってもよい。
両性界面活性剤としては、コカミドプロピルベタイン等の脂肪酸アミドプロピルベタイン;ラウリルジメチルアミノ酢酸ベタイン等のアルキルベタイン;ヤシ油脂肪酸イミダゾリウムベタイン等のイミダゾリン型両性界面活性剤が挙げられ、脂肪酸アミドプロピルベタインが好ましい。両性イオン性界面活性剤は、組成物全体の10%以下配合することができ、0%であってもよい。 Examples of the surfactant include nonionic surfactants and amphoteric surfactants, which may be used alone or in combination of two or more.
Nonionic surfactants include: polyoxyethylene hydrogenated castor oil; polyoxyethylene fatty acid ester; polyglycerin fatty acid ester; sucrose fatty acid ester such as maltose fatty acid ester; sugar alcohol fatty acid such as maltitol fatty acid ester and lactitol fatty acid ester Esters; alkylol amides; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate; fatty acid diethanolamides such as lauric acid mono- or diethanolamide; sorbitan fatty acid esters; polyoxyethylene alkyl ethers; polyoxyethylene polyoxypropylene Copolymer; polyoxyethylene polyoxypropylene fatty acid ester. The nonionic surfactant can be blended in an amount of 10% or less of the entire composition, and may be 0%.
Examples of amphoteric surfactants include fatty acid amidopropyl betaines such as cocamidopropyl betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine; imidazoline type amphoteric surfactants such as coconut oil fatty acid imidazolium betaine, and fatty acid amidopropyl betaines. Is preferred. The zwitterionic surfactant can be added in an amount of 10% or less of the entire composition, and may be 0%.
非イオン性界面活性剤としては、ポリオキシエチレン硬化ヒマシ油;ポリオキシエチレン脂肪酸エステル;ポリグリセリン脂肪酸エステル;マルトース脂肪酸エステル等のショ糖脂肪酸エステル;マルチトール脂肪酸エステル、ラクチトール脂肪酸エステル等の糖アルコール脂肪酸エステル;アルキロールアマイド;ポリオキシエチレンソルビタンモノステアレート等のポリオキシエチレンソルビタン脂肪酸エステル;ラウリル酸モノ又はジエタノールアミド等の脂肪酸ジエタノールアミド;ソルビタン脂肪酸エステル;ポリオキシエチレンアルキルエーテル;ポリオキシエチレンポリオキシプロピレン共重合体;ポリオキシエチレンポリオキシプロピレン脂肪酸エステルが挙げられる。非イオン性界面活性剤は、組成物全体の10%以下配合することができ、0%であってもよい。
両性界面活性剤としては、コカミドプロピルベタイン等の脂肪酸アミドプロピルベタイン;ラウリルジメチルアミノ酢酸ベタイン等のアルキルベタイン;ヤシ油脂肪酸イミダゾリウムベタイン等のイミダゾリン型両性界面活性剤が挙げられ、脂肪酸アミドプロピルベタインが好ましい。両性イオン性界面活性剤は、組成物全体の10%以下配合することができ、0%であってもよい。 Examples of the surfactant include nonionic surfactants and amphoteric surfactants, which may be used alone or in combination of two or more.
Nonionic surfactants include: polyoxyethylene hydrogenated castor oil; polyoxyethylene fatty acid ester; polyglycerin fatty acid ester; sucrose fatty acid ester such as maltose fatty acid ester; sugar alcohol fatty acid such as maltitol fatty acid ester and lactitol fatty acid ester Esters; alkylol amides; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate; fatty acid diethanolamides such as lauric acid mono- or diethanolamide; sorbitan fatty acid esters; polyoxyethylene alkyl ethers; polyoxyethylene polyoxypropylene Copolymer; polyoxyethylene polyoxypropylene fatty acid ester. The nonionic surfactant can be blended in an amount of 10% or less of the entire composition, and may be 0%.
Examples of amphoteric surfactants include fatty acid amidopropyl betaines such as cocamidopropyl betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine; imidazoline type amphoteric surfactants such as coconut oil fatty acid imidazolium betaine, and fatty acid amidopropyl betaines. Is preferred. The zwitterionic surfactant can be added in an amount of 10% or less of the entire composition, and may be 0%.
湿潤剤としては、ソルビット、グリセリン、プロピレングリコール、平均分子量200~6,000(医薬部外品原料規格記載の平均分子量)のポリエチレングリコール、エチレングリコ-ル、1,3-ブチレングリコール、エリスリトール、キシリトール、トリメチルグリシン、還元でんぷん糖化物等の多価アルコール、糖アルコールが挙げられる。
これら湿潤剤の配合量は、組成物全体の0.1~70%が好ましい。 Wetting agents include sorbit, glycerin, propylene glycol, polyethylene glycol, ethylene glycol, 1,3-butylene glycol, erythritol, xylitol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications) And polyhydric alcohols such as trimethylglycine and reduced starch saccharified product, and sugar alcohols.
The blending amount of these wetting agents is preferably 0.1 to 70% of the entire composition.
これら湿潤剤の配合量は、組成物全体の0.1~70%が好ましい。 Wetting agents include sorbit, glycerin, propylene glycol, polyethylene glycol, ethylene glycol, 1,3-butylene glycol, erythritol, xylitol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications) And polyhydric alcohols such as trimethylglycine and reduced starch saccharified product, and sugar alcohols.
The blending amount of these wetting agents is preferably 0.1 to 70% of the entire composition.
甘味剤としては、サッカリンナトリウム、ステビオサイド、ステビアエキス、パラメトキシシンナミックアルデヒド、ネオヘスペリジルジヒドロカルコン、ペリラルチン、グリチルリチン、ソーマチン、アスパラチルフェニルアラニンメチルエステル等が挙げられる。
Sweetening agents include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like.
香料としては、公知の香料、例えばメントール、アネトール、カルボン、オイゲノール、リモネン、n-デシルアルコール、シトロネロール、α-テルピネオール、シトロネリルアセテート、シネオール、リナロール、エチルリナロール、ワニリン、チモール、スペアミント油、ペパーミント油、レモン油、オレンジ油、セージ油、ローズマリー油、桂皮油、ピメント油、桂葉油、シソ油、冬緑油、丁字油、ユーカリ油等が挙げられる。
As the fragrance, known fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil , Lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like.
pH調整剤としては、クエン酸、乳酸等の有機酸やその塩類;塩酸、水酸化ナトリウム、水酸化カリウム、リン酸水素二ナトリウム、リン酸二水素ナトリウム等の無機化合物が挙げられる。
防腐剤としては、パラオキシ安息香酸エステル、安息香酸ナトリウム等が挙げられる。 Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
防腐剤としては、パラオキシ安息香酸エステル、安息香酸ナトリウム等が挙げられる。 Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
薬効成分としては、デキストラナーゼ、アミラーゼ、プロテアーゼ、ムタナーゼ等の酵素;トラネキサム酸、イプシロンアミノカプロン酸、アズレン、グリチルリチン酸塩、グリチルレチン酸塩等の抗炎症剤;塩化ナトリウム、ビタミン類、アラントイン類等の細胞賦活剤;イソプロピルメチルフェノール、塩化セチルピリジニウム、塩化ベンザルコニウム、ヒノキチオール、塩化リゾチーム等の殺菌剤;銅クロロフィル、グルコン酸銅等の水溶性銅化合物;ピロリン酸塩類、ポリリン酸塩類、ヘキサメタリン酸塩、ゼオライト等の歯石予防剤;ビタミンE等の血行促進剤;アラニン、グリシン、プロリン等のアミノ酸類;ローズマリー、シラカバ等の植物抽出物を配合できる。なお、薬効成分の配合量は、本発明の効果を妨げない範囲で有効量とすることができる。
Medicinal ingredients include enzymes such as dextranase, amylase, protease, mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate; sodium chloride, vitamins, allantoins, etc. Cell activators; bactericides such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; pyrophosphates, polyphosphates, hexametaphosphate Calcium preventive agents such as zeolite, blood circulation promoters such as vitamin E, amino acids such as alanine, glycine and proline; plant extracts such as rosemary and birch. In addition, the compounding quantity of a medicinal ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.
更に、任意成分として、雲母チタン、酸化チタン、ベントナイト等の無機化合物;結晶性セルロース等のセルロース系の有機粉末;寒天、ゼラチン、デンプン、グルコマンナン等の天然高分子化合物;ポリ酢酸ビニル、アクリル樹脂、ポリウレタン、ポリエステル、ポリ塩化ビニル、ナイロン末、ポリエチレン末等の合成高分子化合物又はそれらの共重合体;カルナバワックス、ロジン、ライスワックス、マイクロクリスタリンワックス、ミツロウ、パラフィンワックス等のワックス類;セタノール、ステアリルアルコール等の高級アルコール;ポリイソブチレン、ポリブタジエン、シリコーン、天然ゴムを、本発明の効果を妨げない範囲で配合することができる。
Further, as optional components, inorganic compounds such as titanium mica, titanium oxide, bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, glucomannan; polyvinyl acetate, acrylic resin Synthetic polymers such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.
以下、実施例及び比較例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、下記の例において%は特に断らない限りいずれも質量%を示す。
Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.
[実施例、比較例]
表1~3に示す組成の練歯磨剤組成物を常法によって調製し、サンプルとして用いて下記の(1)~(3)に示す方法によって評価した。更に、表3に示す組成については、下記の(4)に示す方法によっても評価した。結果を表に併記した。 [Examples and Comparative Examples]
Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method, and used as samples, and evaluated by the methods shown in (1) to (3) below. Furthermore, the composition shown in Table 3 was also evaluated by the method shown in (4) below. The results are shown in the table.
表1~3に示す組成の練歯磨剤組成物を常法によって調製し、サンプルとして用いて下記の(1)~(3)に示す方法によって評価した。更に、表3に示す組成については、下記の(4)に示す方法によっても評価した。結果を表に併記した。 [Examples and Comparative Examples]
Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method, and used as samples, and evaluated by the methods shown in (1) to (3) below. Furthermore, the composition shown in Table 3 was also evaluated by the method shown in (4) below. The results are shown in the table.
<評価方法>
(1)液垂れのなさ
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、3分間歯磨きしたときの口からのサンプルの液垂れ(液や泡の垂れ)の度合いについて、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:歯磨き開始後3分経過しても、サンプルが口から垂れなかった
3点:歯磨き開始後2分を超えて3分以内に、サンプルが口から垂れ
た
2点:歯磨き開始後1分を超えて2分以内に、サンプルが口から垂れ
た
1点:歯磨き開始後1分以内に、サンプルが口から垂れた
評価基準
◎:3.5点以上
○:2.0点を超え3.5点未満
×:2.0点以下 <Evaluation method>
(1) No dripping About the degree of dripping (dropping of liquid or foam) from the mouth when a specialized panelist (subjects, 3 people) took 1g sample on toothbrush and brushed for 3 minutes Judgment was made using the following criteria. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Rating criteria 4 points: The sample did not sag from the mouth even after 3 minutes passed from the start of brushing. 3 points: The sample slid from the mouth within 2 minutes after 2 minutes after the start of brushing. The sample dropped from the mouth within 2 minutes after 1 minute. 1 point: The sample dropped from the mouth within 1 minute after starting brushing. Evaluation criteria ◎: More than 3.5 points ○: Over 2.0 points Less than 3.5 points ×: 2.0 points or less
(1)液垂れのなさ
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、3分間歯磨きしたときの口からのサンプルの液垂れ(液や泡の垂れ)の度合いについて、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:歯磨き開始後3分経過しても、サンプルが口から垂れなかった
3点:歯磨き開始後2分を超えて3分以内に、サンプルが口から垂れ
た
2点:歯磨き開始後1分を超えて2分以内に、サンプルが口から垂れ
た
1点:歯磨き開始後1分以内に、サンプルが口から垂れた
評価基準
◎:3.5点以上
○:2.0点を超え3.5点未満
×:2.0点以下 <Evaluation method>
(1) No dripping About the degree of dripping (dropping of liquid or foam) from the mouth when a specialized panelist (subjects, 3 people) took 1g sample on toothbrush and brushed for 3 minutes Judgment was made using the following criteria. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Rating criteria 4 points: The sample did not sag from the mouth even after 3 minutes passed from the start of brushing. 3 points: The sample slid from the mouth within 2 minutes after 2 minutes after the start of brushing. The sample dropped from the mouth within 2 minutes after 1 minute. 1 point: The sample dropped from the mouth within 1 minute after starting brushing. Evaluation criteria ◎: More than 3.5 points ○: Over 2.0 points Less than 3.5 points ×: 2.0 points or less
(2)サッパリ感
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、3分間歯磨きし、口内を水ですすいだ後のサッパリ感について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:非常にサッパリ感を感じた
3点:かなりサッパリ感を感じた
2点:ややサッパリ感を感じた
1点:サッパリ感を感じなかった
評価基準
◎:3.0点以上
○:2.0点以上3.0点未満
×:2.0点未満 (2) Refreshing feeling Special panelists (subjects, 3 persons) took a 1 g sample on a toothbrush, brushed their teeth for 3 minutes, and rinsed their mouths with water to determine the refreshing feeling using the following criteria. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Rating criteria 4 points: I felt a very refreshing feeling 3 points: I felt a very refreshing feeling 2 points: I felt a little refreshing feeling 1 point: I did not feel a refreshing feeling Evaluation criteria ◎: More than 3.0 points ○: 2.0 points or more and less than 3.0 points ×: less than 2.0 points
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、3分間歯磨きし、口内を水ですすいだ後のサッパリ感について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:非常にサッパリ感を感じた
3点:かなりサッパリ感を感じた
2点:ややサッパリ感を感じた
1点:サッパリ感を感じなかった
評価基準
◎:3.0点以上
○:2.0点以上3.0点未満
×:2.0点未満 (2) Refreshing feeling Special panelists (subjects, 3 persons) took a 1 g sample on a toothbrush, brushed their teeth for 3 minutes, and rinsed their mouths with water to determine the refreshing feeling using the following criteria. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Rating criteria 4 points: I felt a very refreshing feeling 3 points: I felt a very refreshing feeling 2 points: I felt a little refreshing feeling 1 point: I did not feel a refreshing feeling Evaluation criteria ◎: More than 3.0 points ○: 2.0 points or more and less than 3.0 points ×: less than 2.0 points
(3)刺激のなさ
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、3分間歯磨きし、口内を水ですすいだ後の刺激感について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:刺激を感じなかった
3点:ほとんど刺激を感じなかった
2点:やや刺激を感じた
1点:強い刺激を感じた
評価基準
◎:3.5点以上
○:2.5点以上3.5点未満
×:2.5点未満 (3) No irritation Expert panelists (3 subjects) took a 1g sample on a toothbrush, brushed their teeth for 3 minutes, and rinsed their mouth with water. . The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Evaluation criteria 4 points: I did not feel stimulation 3 points: I hardly felt stimulation 2 points: I felt somewhat stimulation 1 point: I felt strong stimulation Evaluation criteria ◎: 3.5 points or more ○: 2.5 points Or more, less than 3.5 points ×: less than 2.5 points
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、3分間歯磨きし、口内を水ですすいだ後の刺激感について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:刺激を感じなかった
3点:ほとんど刺激を感じなかった
2点:やや刺激を感じた
1点:強い刺激を感じた
評価基準
◎:3.5点以上
○:2.5点以上3.5点未満
×:2.5点未満 (3) No irritation Expert panelists (3 subjects) took a 1g sample on a toothbrush, brushed their teeth for 3 minutes, and rinsed their mouth with water. . The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Evaluation criteria 4 points: I did not feel stimulation 3 points: I hardly felt stimulation 2 points: I felt somewhat stimulation 1 point: I felt strong stimulation Evaluation criteria ◎: 3.5 points or more ○: 2.5 points Or more, less than 3.5 points ×: less than 2.5 points
(4)口腔内での分散性
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、歯磨きを開始後の口腔内でのペーストの分散性について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:ペーストの分散性が非常によかった
3点:ペーストの分散性がかなりよかった
2点:ペーストの分散性がややよかった
1点:ペーストの分散性がよくなかった
評価基準
◎:3.0点以上
○:2.5点以上3.0点未満
×:2.5点未満 (4) Dispersibility in the oral cavity Special panelists (subjects, 3 persons) take a 1g sample on a toothbrush, and determine the dispersibility of the paste in the oral cavity after starting toothbrushing using the following criteria. did. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Rating criteria 4 points: Dispersibility of the paste was very good 3 points: Dispersibility of the paste was quite good 2 points: Dispersibility of the paste was slightly good 1 point: Dispersibility of the paste was not good Evaluation criteria A: 3. 0 or more ○: 2.5 or more and less than 3.0 × ×: less than 2.5
専門パネラー(被験者、3人)がハブラシ上に1gのサンプルを取り、歯磨きを開始後の口腔内でのペーストの分散性について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:ペーストの分散性が非常によかった
3点:ペーストの分散性がかなりよかった
2点:ペーストの分散性がややよかった
1点:ペーストの分散性がよくなかった
評価基準
◎:3.0点以上
○:2.5点以上3.0点未満
×:2.5点未満 (4) Dispersibility in the oral cavity Special panelists (subjects, 3 persons) take a 1g sample on a toothbrush, and determine the dispersibility of the paste in the oral cavity after starting toothbrushing using the following criteria. did. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria.
Rating criteria 4 points: Dispersibility of the paste was very good 3 points: Dispersibility of the paste was quite good 2 points: Dispersibility of the paste was slightly good 1 point: Dispersibility of the paste was not good Evaluation criteria A: 3. 0 or more ○: 2.5 or more and less than 3.0 × ×: less than 2.5
使用原料の詳細を下記に示す。
(A)ラウリル硫酸ナトリウム:Texapon(BASF社製)
(A)テトラデセンスルホン酸ナトリウム:
KリポランPJ-400CJ(ライオン・スペシャリティ・ケミカル
ズ(株)製)
(B)キサンタンガム:モナートガムDA(CPケルコ社製)
カルボキシメチルセルロースナトリウム(比較品、ダイセル・ファインケム(株)製)
(C)炭酸水素ナトリウム:重炭酸ナトリウム(旭硝子(株)製)
(D)ポリアクリル酸ナトリウム:レオジック260H(東亞合成(株)製
)
(D)アルギン酸ナトリウム:キミカアルギン((株)キミカ製)
研磨性シリカ:TIXOSIL 73(Rhodia社製)
増粘性シリカ:カープレックス #67 (DSLジャパン(株)製) Details of the raw materials used are shown below.
(A) Sodium lauryl sulfate: Texapon (manufactured by BASF)
(A) Sodium tetradecene sulfonate:
K Lipolane PJ-400CJ (manufactured by Lion Specialty Chemicals)
(B) Xanthan gum: Monato gum DA (CP Kelco)
Sodium carboxymethylcellulose (Comparative product, manufactured by Daicel FineChem Co., Ltd.)
(C) Sodium bicarbonate: Sodium bicarbonate (Asahi Glass Co., Ltd.)
(D) Sodium polyacrylate: Leogic 260H (manufactured by Toagosei Co., Ltd.)
(D) Sodium alginate: Kimika Argin (made by Kimika Co., Ltd.)
Abrasive silica: TIXOSIL 73 (manufactured by Rhodia)
Thickening silica: Carplex # 67 (manufactured by DSL Japan)
(A)ラウリル硫酸ナトリウム:Texapon(BASF社製)
(A)テトラデセンスルホン酸ナトリウム:
KリポランPJ-400CJ(ライオン・スペシャリティ・ケミカル
ズ(株)製)
(B)キサンタンガム:モナートガムDA(CPケルコ社製)
カルボキシメチルセルロースナトリウム(比較品、ダイセル・ファインケム(株)製)
(C)炭酸水素ナトリウム:重炭酸ナトリウム(旭硝子(株)製)
(D)ポリアクリル酸ナトリウム:レオジック260H(東亞合成(株)製
)
(D)アルギン酸ナトリウム:キミカアルギン((株)キミカ製)
研磨性シリカ:TIXOSIL 73(Rhodia社製)
増粘性シリカ:カープレックス #67 (DSLジャパン(株)製) Details of the raw materials used are shown below.
(A) Sodium lauryl sulfate: Texapon (manufactured by BASF)
(A) Sodium tetradecene sulfonate:
K Lipolane PJ-400CJ (manufactured by Lion Specialty Chemicals)
(B) Xanthan gum: Monato gum DA (CP Kelco)
Sodium carboxymethylcellulose (Comparative product, manufactured by Daicel FineChem Co., Ltd.)
(C) Sodium bicarbonate: Sodium bicarbonate (Asahi Glass Co., Ltd.)
(D) Sodium polyacrylate: Leogic 260H (manufactured by Toagosei Co., Ltd.)
(D) Sodium alginate: Kimika Argin (made by Kimika Co., Ltd.)
Abrasive silica: TIXOSIL 73 (manufactured by Rhodia)
Thickening silica: Carplex # 67 (manufactured by DSL Japan)
Claims (7)
- (A)アニオン性界面活性剤 1.4~2.5質量%、
(B)キサンタンガム 1.4~2.5質量%、
及び
(C)炭酸水素塩 0.1~5質量%
を含有する歯磨剤組成物。 (A) anionic surfactant 1.4-2.5% by mass,
(B) xanthan gum 1.4-2.5% by mass,
And (C) bicarbonate 0.1 to 5% by mass
A dentifrice composition containing - (A)成分が、スルホン酸基を含有するアニオン性界面活性剤である請求項1記載の歯磨剤組成物。 The dentifrice composition according to claim 1, wherein the component (A) is an anionic surfactant containing a sulfonic acid group.
- (C)炭酸水素塩が炭酸水素ナトリウムであり、その含有量が0.1~3質量%である請求項1又は2記載の歯磨剤組成物。 (C) The dentifrice composition according to claim 1 or 2, wherein the hydrogen carbonate is sodium hydrogen carbonate and the content thereof is 0.1 to 3% by mass.
- (A)/(B)が質量比として0.7~1.7である請求項1~3のいずれか1項記載の歯磨剤組成物。 The dentifrice composition according to any one of claims 1 to 3, wherein (A) / (B) is 0.7 to 1.7 in terms of mass ratio.
- 更に、(D)ポリアクリル酸ナトリウム及びアルギン酸ナトリウムから選ばれる1種以上を0.1~1質量%含有する請求項1~4のいずれか1項記載の歯磨剤組成物。 The dentifrice composition according to any one of claims 1 to 4, further comprising (D) 0.1 to 1% by mass of one or more selected from sodium polyacrylate and sodium alginate.
- (B)/(D)が質量比として1.5~20である請求項5記載の歯磨剤組成物。 The dentifrice composition according to claim 5, wherein (B) / (D) is 1.5 to 20 in terms of mass ratio.
- 更に、(E)研磨剤を8~70質量%含有する請求項1~6のいずれか1項記載の歯磨剤組成物。 The dentifrice composition according to any one of claims 1 to 6, further comprising (E) 8 to 70% by mass of an abrasive.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020197026231A KR20200011409A (en) | 2017-05-31 | 2018-05-30 | Toothpaste Composition |
CN201880033257.3A CN110650722A (en) | 2017-05-31 | 2018-05-30 | Dentifrice composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017107590A JP7347916B2 (en) | 2017-05-31 | 2017-05-31 | dentifrice composition |
JP2017-107590 | 2017-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2018221609A1 true WO2018221609A1 (en) | 2018-12-06 |
Family
ID=64454658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2018/020807 WO2018221609A1 (en) | 2017-05-31 | 2018-05-30 | Dentifrice composition |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP7347916B2 (en) |
KR (1) | KR20200011409A (en) |
CN (1) | CN110650722A (en) |
WO (1) | WO2018221609A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113710328A (en) * | 2019-04-05 | 2021-11-26 | 狮王株式会社 | Dentifrice composition |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6136212A (en) * | 1984-07-26 | 1986-02-20 | Lion Corp | Composition for oral cavity application |
JPH111418A (en) * | 1997-06-10 | 1999-01-06 | Lion Corp | Dentifrice composition |
JP2009137908A (en) * | 2007-12-10 | 2009-06-25 | Lion Corp | Dentifrice composition |
JP2009149540A (en) * | 2007-12-19 | 2009-07-09 | Lion Corp | Dentifrice composition |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08333228A (en) | 1995-06-05 | 1996-12-17 | Lion Corp | Tooth paste composition |
JPH09132517A (en) | 1995-11-09 | 1997-05-20 | Lion Corp | Composition for oral cavity |
JP2002104945A (en) | 2000-07-25 | 2002-04-10 | Lion Corp | Dentifrice composition |
JP5033283B2 (en) | 2001-04-03 | 2012-09-26 | 日本ゼトック株式会社 | Oral composition |
JP3959636B2 (en) | 2002-02-15 | 2007-08-15 | ライオン株式会社 | Toothpaste composition |
JP5923498B2 (en) * | 2011-05-27 | 2016-05-24 | ライオン株式会社 | Oral composition |
CN103998017B (en) * | 2011-12-20 | 2017-04-12 | 狮王株式会社 | Dentrifice composition |
-
2017
- 2017-05-31 JP JP2017107590A patent/JP7347916B2/en active Active
-
2018
- 2018-05-30 KR KR1020197026231A patent/KR20200011409A/en not_active Application Discontinuation
- 2018-05-30 WO PCT/JP2018/020807 patent/WO2018221609A1/en active Application Filing
- 2018-05-30 CN CN201880033257.3A patent/CN110650722A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6136212A (en) * | 1984-07-26 | 1986-02-20 | Lion Corp | Composition for oral cavity application |
JPH111418A (en) * | 1997-06-10 | 1999-01-06 | Lion Corp | Dentifrice composition |
JP2009137908A (en) * | 2007-12-10 | 2009-06-25 | Lion Corp | Dentifrice composition |
JP2009149540A (en) * | 2007-12-19 | 2009-07-09 | Lion Corp | Dentifrice composition |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113710328A (en) * | 2019-04-05 | 2021-11-26 | 狮王株式会社 | Dentifrice composition |
CN113710328B (en) * | 2019-04-05 | 2024-01-09 | 狮王株式会社 | Dentifrice composition |
Also Published As
Publication number | Publication date |
---|---|
CN110650722A (en) | 2020-01-03 |
KR20200011409A (en) | 2020-02-03 |
JP2018203640A (en) | 2018-12-27 |
JP7347916B2 (en) | 2023-09-20 |
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