JP4645830B2 - Dentifrice composition and method for improving dry resistance of dentifrice composition - Google Patents

Description

The present invention relates to a dentifrice composition having excellent dry resistance at the mouth of a filled tube, having no stickiness in the oral cavity, and having excellent storage stability, and a method for improving the dry resistance of the dentifrice composition. It is.

  Conventionally, a toothpaste composition has been blended with a wetting agent for the purpose of imparting appropriate moisture and preventing the toothpaste composition from drying and solidifying (Non-Patent Document 1). Solidification of the toothpaste composition is considered to be due to the interaction of the contents of the abrasive, the water-soluble polymer binder, the wetting agent, and water. In particular, solidification is often observed in a toothpaste composition containing calcium phosphate as an abrasive, and various methods for preventing such solidification of the toothpaste composition have been proposed. For example, nonionic activator (Patent Document 1), condensation Additives such as phosphoric acid (Patent Document 2), polyvinylpyrrolidone (Patent Document 3), polyethylene glycol (Patent Document 4), and tertiary magnesium phosphate (Patent Document 5) have been proposed. Moreover, the solidification prevention effect by combined use of polyvinylpyrrolidone having a specific molecular weight and a polyhydric alcohol (Patent Document 6) has also been proposed.

  Thus, although several proposals have been made for preventing the solidification of the toothpaste composition, drying of the toothpaste composition, which depends greatly on the state of water, in particular, the use of the toothpaste composition is finished from the beginning of use. There has been no report on a method for preventing the toothpaste composition from drying out at the mouth of a filled tube that is in contact with the outside air for a long period of time.

  On the other hand, trimethylglycine is also called as glycine betaine or betaine, and is a known substance widely used as an amino acid-based moisturizing agent in skin cosmetics and hair cosmetics. As an application example in the oral cavity, the effect of removing plaque by using in combination with various enzymes has been reported (Patent Document 7). Furthermore, with respect to trimethylglycine, according to Non-Patent Document 2, the effect of suppressing the irritation of the active agent on the oral mucosa was reported, and the moisturizing effect of the oral mucosa was also reported as well as on the skin (Patent Document 8) Non-Patent Document 3). Furthermore, it has been reported that the smoothness and refreshing feeling of teeth after oral cleaning with a mouthwash can be obtained by using in combination with an anionic active agent (Patent Document 9). As described above, trimethylglycine is known for its moisturizing effect on the skin and oral mucosa and for improving the feeling of use in the oral cavity, but when applied to a toothpaste composition, the toothpaste composition can be dried at the mouth. In terms of preventing drastically and reducing the stickiness when used in the oral cavity, both were insufficient.

JP-A-50-19938 Japanese Patent Laid-Open No. 50-19939 JP-A-56-97216 JP-A-56-97217 Japanese Patent Laid-Open No. 60-104090 JP 2003-55178 A Japanese Patent Laid-Open No. 9-25221 JP-T-2001-508423 JP 2004-217614 A Edited by the Japan Dentifrice Industry Association “Science of Dentifrice” Gakuken Shoin Publishing, July 6, 1994, p21-24 Acta Odontol Scan (2002), 60 (5), p306-310 J Contemp Dent Pract (2003), 4 (2), p11-23

The present invention has been made in view of the above circumstances, and is a method for improving the dry resistance of a dentifrice composition and a dentifrice composition that has excellent dry resistance at the mouth of a filled tube, good usability, and excellent storage stability. The purpose is to provide.

  As a result of intensive studies to meet the above-mentioned demands, the present inventors have developed a dentifrice composition containing water, a wetting agent and a binder, and having a water / wetting agent mass ratio of 1.2 to 4. Furthermore, by adding trimethylglycine, it was unexpectedly superior in dry resistance at the mouth of the filled tube, there was no stickiness during use, and the storage stability (liquid separation) was further improved. It has been reached.

Accordingly, the present invention provides the following dentifrice composition and a method for improving the drought resistance of the dentifrice composition .
Claim 1:
(A) 20-65% by weight of water, and
(B) 10 to 35% by mass of one or more wetting agents selected from sorbitol, glycerin, propylene glycol and 1,3-butylene glycol
And the mass ratio of component (A) / component (B) is 1.2-4,
(C) Sodium alginate, carrageenan, xanthan gum, carboxymethylcellulose salt, hydroxyethylcellulose salt, polyacrylic acid and its sodium salt, methylcellulose, tragacanth gum, karaya gum, gum arabic, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, polyvinylpyrrolidone, carbon 0.8 to 1.4% by mass of one or more binders selected from pole and veegum
A dentifrice composition comprising 1 to 30% by mass of (D) trimethylglycine in a dentifrice composition containing and containing an abrasive.
Claim 2:
(B) The dentifrice composition according to claim 1, wherein the wetting agent is selected from sorbitol, glycerin and propylene glycol.
Claim 3:
(C) The dentifrice composition according to claim 1 or 2, wherein the binder is selected from carrageenan, xanthan gum, carboxymethylcellulose salt, and sodium polyacrylate.
Claim 4 :
(A) 20-65% by weight of water, and
(B) 10 to 35% by mass of one or more wetting agents selected from sorbitol, glycerin, propylene glycol and 1,3-butylene glycol
And the mass ratio of component (A) / component (B) is 1.2-4,
(C) Sodium alginate, carrageenan, xanthan gum, carboxymethylcellulose salt, hydroxyethylcellulose salt, polyacrylic acid and its sodium salt, methylcellulose, tragacanth gum, karaya gum, gum arabic, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, polyvinylpyrrolidone, carbon 0.8 to 1.4% by mass of one or more binders selected from pole and veegum
(D) 1-30 mass% of trimethylglycine is mix | blended with the dentifrice composition which contains and contains the abrasive | polishing agent, The method of improving the drought resistance of the said dentifrice composition characterized by the above-mentioned.

  The dentifrice composition of the present invention has excellent drying resistance at the mouth of the filled tube, does not feel sticky during use, and can achieve better storage stability (liquid separation).

  The dentifrice composition according to the present invention contains (A) water, (B) a wetting agent, (C) a binder, and a mass ratio of (A) water / (B) wetting agent is 1.2 to 4. In addition, it further contains (D) trimethylglycine and is effectively used as a dentifrice composition.

Dentifrice composition of the present invention uses the (A) water, the amount of water, Ri 20-65% by mass of the total composition, in particular sticky main, in that obtaining the drying resistance more preferably 25-65 wt%, more preferably from 30 to 65 wt%. When the amount of water is less than 20% by mass, stickiness may occur in the oral cavity, and when it is more than 75% by mass, drying may become strong.

Furthermore, the dentifrice compositions of the present invention, (B) using a wetting agent. The preferred wetting agents, sorbitol, glycerin, propylene glycol, 1,3-butylene glycol. Among these, sorbitol, propylene glycol Is preferable from the viewpoint of obtaining the desired drying resistance. Two or more kinds of these wetting agents can be blended as necessary. (B) The amount of wetting agent, especially sticky main, from 10 to 35% by weight of the total composition from the viewpoint of realizing the drying resistance. When the blending amount of the wetting agent is less than 5% by mass, the drying resistance is insufficient, and when it exceeds 45% by mass, the sticky feeling may become strong.

  In the present invention, the mass ratio of component (A) / component (B) is 1.2-4. It is preferably 1.4 to 4 and more preferably 1.6 to 3 in terms of satisfying both non-stickiness and drying resistance. When the mass ratio of the component (A) / component (B) is less than 1.2, a sticky feeling is strong, and when it exceeds 4, the drying resistance is insufficient.

(C) As binder, sodium alginate, carrageenan, xanthan gum, carboxymethylcellulose salt, hydroxyethylcellulose salt, polyacrylic acid or sodium salt thereof, methylcellulose, tragacanth gum, karaya gum, gum arabic, locust bean gum, polyvinyl alcohol, carboxyvinyl Examples thereof include polymers, polyvinyl pyrrolidone, carbopol, and bee gum. Among these, carrageenan, xanthan gum, carboxymethylcellulose salt, and sodium polyacrylate are preferable in terms of non-stickiness and prevention of liquid separation. These Nebayuizai can be blended one or more kinds, the amount is 0.8 to 1.4% by weight of the total composition in terms of maintaining a particularly sufficient drying resistance. When the amount of the binder is less than 0.5% by mass, storage stability is insufficient such as liquid separation, and when it exceeds 2.0% by mass, stickiness becomes strong.

  The carboxymethyl cellulose may be any carboxymethyl cellulose as long as it is normally used in oral compositions, but the viscosity (25 ° C., rotor used: No. 4, 20 rpm, 2% aqueous solution measured with a BH viscometer, (1 minute) is 200 to 7,000 mPa · s, and the degree of etherification is preferably 0.6 to 1. The sodium polyacrylate may be any one as long as it is usually used in an oral composition, but the viscosity of a 0.5% aqueous solution at 25 ° C. (BH viscometer, rotor used: No. 5, 20 rpm, 1 minute) is 5-15 Pa.s.

The dentifrice composition of the present invention contains (D) trimethylglycine. The amount of trimethylglycine is preferably 1 - 30% by weight of the total composition, particularly drought tolerance, 1-15% by weight and more preferably in that to realize the lack of stickiness, more preferably 2 to 8% by mass. When the amount of trimethylglycine is less than 0.1% by mass, sufficient drying resistance cannot be obtained, and when it exceeds 30% by mass, it may not be dissolved in the dentifrice composition.

  In addition to the components described above, the oral composition of the present invention can be blended with various components that are usually used in dentifrice compositions as long as the effects of the present invention are not impaired. Other ingredients that can be blended include surfactants, abrasives, sweeteners, fragrances, pH adjusters and preservatives.

  As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended. As the anionic surfactant, sodium lauryl sulfate, sodium myristyl sulfate, N -Sodium lauroyl sarcosinate, sodium N-myristol sarcosinate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoyl glutamate, etc. N-acyl taurates such as N-acyl glutamate and N-methyl-N-acyl taurine sodium are listed.

  Nonionic surfactants include sucrose fatty acid esters, sucrose fatty acid esters such as maltose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester, lactol fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, etc. Polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, fatty acid diethanolamide such as lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene Examples include copolymers, polyoxyethylene polyoxypropylene fatty acid esters, polyglycerin fatty acid esters, and pluronics.

  Further, as the zwitterionic surfactant, N-alkyldiaminoethylglycine such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, or N -Alkyl-1-hydroxyethyl imidazoline betaine sodium etc. are mentioned. These surfactants may be used alone or in combination of two or more.

  The compounding quantity of surfactant can be 0.1-2 mass% of the whole composition.

As abrasives, dicalcium phosphate dihydrate and anhydrous salts, calcium phosphate compounds such as primary calcium phosphate, tertiary calcium phosphate and calcium pyrophosphate, silica compounds such as precipitated silica and aluminosilicate, calcium carbonate, water One or more of calcium oxide, aluminum hydroxide, aluminum silicate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite and the like can be blended. In addition, the compounding amount of the abrasive may be suitable for an electric toothbrush dentifrice composition without an abrasive, but in the case of a normal toothpaste composition, it is preferably 5 to 50% by mass. .

  Sweetening agents include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like. In addition, the compounding quantity of a sweetener can be 0.01-5 mass% of the whole composition.

  As fragrances, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange Oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, clove oil or eucalyptus oil. As a compounding quantity of a fragrance | flavor, it can be set as 0.001-2 mass%.

  Examples of the pH adjuster include organic acids such as citric acid, lactic acid and malic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate. .

  In addition to these components, the composition of the present invention includes medicinal or active ingredients such as dextranase, amylase, protease, mutanase and other enzymes, alkali metal monofluorophosphate such as sodium monofluorophosphate, fluoride Sodium, fluoride such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetic acid, sodium chloride, vitamins and other anti-inflammatory agents, copper chlorophyll, copper gluconate , Bactericides such as cetylpyridinium chloride, benzalkonium chloride, triclosan, hinokitiol, lysozyme chloride, calculus preventives such as polyphosphates, tobacco crab removers, amino acids such as glycine and proline, aluminum lactate, Hypersensitivity inhibitors such as potassium can be formulated.

  In addition, inorganic compounds such as calcium hydrogen phosphate, zeolite, and hydroxyapatite, granulated products thereof, granulated products of organic powders such as crystalline cellulose, natural polymers such as agar, gelatin, starch, and glucomannan, Synthetic polymers such as vinyl acetate, acrylic, polyurethane, polyester, polyamide, polyvinyl chloride, waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax, higher alcohols such as cetanol and stearyl alcohol, It is possible to use those obtained by crosslinking, polymerizing and molding latex rubber such as polyisobutylene, polybutadiene, polyurethane, silicone, natural rubber, etc., or those obtained by mixing these raw materials and lame films. it can. Lamé films include organic resin laminated film powder, laminated film powder in which a vapor deposition layer such as aluminum is introduced into the organic resin laminated film, specifically polyethylene terephthalate / polymethyl methacrylate laminated film powder, polyethylene terephthalate / aluminum. -Epoxy laminated powder can be used.

  The dentifrice composition of the present invention is usually filled and stored in a tube. In this case, a known tube can be used as the tube, such as a plastic tube, a metal foil laminated plastic tube such as an aluminum foil, and the like. Although it can use, it is not restricted to this, For example, it is filled and used also in a pump type container etc., and the same effect as the case where it fills with a tube is given.

  Hereinafter, the dry resistance of the tube mouth using the composition example (Example) corresponding to the dentifrice composition of the present invention and the non-applicable composition example (Comparative Example), stickiness in the oral cavity at the time of use, storage stability (liquid) Examples of separation) will be shown and the features and excellent effects of the present invention will be specifically described. However, the present invention is not limited to the following examples.

[Examples 1 to 5, Comparative Examples 1 to 4]
A toothpaste composition containing the components shown in Table 1 was prepared by a conventional method, and the dry resistance at the mouth of the tube, the absence of stickiness in the oral cavity, and storage stability (liquid separation) were evaluated by the following methods. .
<Dry resistance of tube mouth>
The test dentifrice composition was filled into a laminate tube having a diameter of 8 mm, and the dentifrice composition was once extruded to the mouth, and then left in a thermostatic bath at 35 ° C. for 2 weeks with the cap removed. The dentifrice composition adhering to the mouth of the tube after being left was extruded onto paper, and the appearance of the dentifrice composition was evaluated visually and by hand.
◎: The surface and the inside are not dried ○: The surface is slightly dried, but the inside is not dried △: The surface is dried, and the inside is slightly dried ×: Both the surface and the inside are dried Dried and solidified and was crispy
<No stickiness in the oral cavity>
Evaluation was conducted by a sensory test using 10 professional panelists. The test dentifrice composition filled in a laminated tube having a diameter of 8 mm was placed on a toothbrush by about 1.5 cm and usually used for brushing teeth. The stickiness in the oral cavity during use was evaluated according to the following criteria.
4 points: I did not feel sticky 3 points: I felt slightly sticky 2 points: I felt sticky 1 point: I felt strongly sticky I showed the average value of the results of evaluation by 10 expert panelists based on .
◎: Average score is 3.5 or more and 4.0 points ○: Average score is 3.0 or more and less than 3.5 points △: Average score is 2.0 or more and less than 3.0 points ×: Average score is 2 Less than 0 points
<Evaluation of storage stability>
The test dentifrice composition was filled into a laminate tube having an aperture of 8 mm, stored in a thermostatic bath at 50 ° C. for 4 weeks, and then evaluated for liquid separation when extruded from the tube onto paper.
◎: No liquid separation is observed △: Some liquid separation is observed ×: Liquid separation is performed

* 1 70% sorbitol: manufactured by Toa Kasei Kogyo Co., Ltd., trade name; 70% sorbit solution * 2 propylene glycol: manufactured by Sakamoto Yakuhin Kogyo Co., Ltd., trade name: propylene glycol * 3 The blending amount was calculated in a pure amount.
* 4 Sodium carboxymethyl cellulose: manufactured by Daicel Chemical Industries, Ltd., trade name: CMC 1260, degree of etherification: 0.9, 2% aqueous solution viscosity: 1,100 mPa · s
* 5 Sodium polyacrylate: manufactured by Nippon Pure Chemical Co., Ltd., trade name: Rheological 250H, 0.5% aqueous solution viscosity; 8 Pa · s
* 6 Trimethylglycine: Ajinomoto Co., Inc., trade name: Aqua Dew AN-100
* 7 Sodium lauryl sulfate: manufactured by Toho Chemical Industry Co., Ltd., trade name; sodium lauryl sulfate * 8 Silicic anhydride: manufactured by Ineos, trade name: AC77

  The results of the experiment are as shown in Table 1, and contain (A) water, (B) a wetting agent, (C) a binder, and a mass ratio of (A) component / (B) component is 1.2 to 4 and (D) the dentifrice composition containing trimethylglycine is excellent in dry resistance at the mouth of the filled tube, is not sticky in the oral cavity, and is excellent in storage stability. When the mass ratio of the component (A) / component (B) exceeds 4, the tackiness is good, but drying at the tube mouth occurs and the storage stability is poor. Further, when the mass ratio of the component (A) / the component (B) is less than 1.2, drying at the mouth of the tube and storage stability are slightly improved, but the stickiness in the oral cavity is enhanced. If the component (C) is not contained, good results cannot be obtained in terms of drying resistance and storage stability at the tube mouth. If the component (D) is not blended, the dry resistance at the tube mouth is not good.

  As a result of this experiment, it contains (A) water, (B) a wetting agent, (C) a binder, and the mass ratio of (A) component / (B) component is 1.2 to 4, D) It has been found that by containing trimethylglycine, excellent drying prevention at the mouth of the tube, no stickiness in the oral cavity, and good storage stability can be achieved.

[Examples 6 to 10]
A dentifrice composition having the composition shown in Table 2 was prepared by a conventional method and evaluated in the same manner as in the above Examples. The results are also shown in Table 2.

* 1 The compounding amount was calculated as pure.
* 2 Etherification degree: 0.9, 2% aqueous solution viscosity; 1,100 mPa · s

In these examples, all had excellent drying prevention at the mouth of the tube, no stickiness in the oral cavity, and good storage stability.

Claims (4)

( A) 20 to 65% by mass of water, and (B) 10 to 35% by mass of one or more wetting agents selected from sorbitol, glycerin, propylene glycol and 1,3-butylene glycol.
And the mass ratio of component (A) / component (B) is 1.2-4,
(C) Sodium alginate, carrageenan, xanthan gum, carboxymethylcellulose salt, hydroxyethylcellulose salt, polyacrylic acid and its sodium salt, methylcellulose, tragacanth gum, karaya gum, gum arabic, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, polyvinylpyrrolidone, carbon 0.8 to 1.4% by mass of one or more binders selected from pole and veegum
A dentifrice composition comprising 1 to 30% by mass of (D) trimethylglycine in a dentifrice composition containing and containing an abrasive . (B) The dentifrice composition according to claim 1, wherein the wetting agent is selected from sorbitol, glycerin and propylene glycol. (C) The dentifrice composition according to claim 1 or 2 , wherein the binder is selected from carrageenan, xanthan gum, carboxymethylcellulose salt, and sodium polyacrylate. (A) 20-65% by weight of water, and
(B) 10 to 35% by mass of one or more wetting agents selected from sorbitol, glycerin, propylene glycol and 1,3-butylene glycol
And the mass ratio of component (A) / component (B) is 1.2-4,
(C) Sodium alginate, carrageenan, xanthan gum, carboxymethylcellulose salt, hydroxyethylcellulose salt, polyacrylic acid and its sodium salt, methylcellulose, tragacanth gum, karaya gum, gum arabic, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, polyvinylpyrrolidone, carbon 0.8 to 1.4% by mass of one or more binders selected from pole and veegum
(D) 1-30 mass% of trimethylglycine is mix | blended with the dentifrice composition which contains and contains the abrasive | polishing agent, The method of improving the drought resistance of the said dentifrice composition characterized by the above-mentioned.