JP2013237632A - Oral moisturizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral moisturizer having a high moisture-retaining property that remarkably suppresses drying of an oral cavity by being applied to the oral cavity, and having mutually conflicting characteristics of excellent spreadability allowing easy application and spread and a moderate viscosity making it hard to drip after application.SOLUTION: An oral moisturizer contains a trimethylglycine, a polyacrylate, and a xanthan gum.

Description

  The present invention is for maintaining humidity in the oral cavity, and relates to an oral moisturizing agent that exhibits excellent moisturizing properties and is easy to spread while being difficult to drip after application.

  Most of the components contained in saliva are water, but various other inorganic and organic compounds are also included. For example, it also contains bactericidal components such as amylase and lysozyme for degrading starch, and has the role of once digesting and keeping the oral cavity clean.

  Human saliva secretion amounts to 1-1.5 liters per day, but decreases with age. In addition, salivary secretion may be reduced by autoimmune diseases such as Sjogren's syndrome, diseases such as diabetes and renal failure.

  When salivary secretion decreases, it becomes easy to suffer from oral diseases due to an increase in oral bacteria, and the oral cavity becomes dry, causing symptoms such as pain during meals and speaking and difficulty in swallowing food. There is also data that more than half of the elderly are actually aware of dryness in the oral cavity, especially in bedridden elderly people who cannot close their mouths and the dryness of the oral cavity progresses further. There is a problem that gets worse.

  Artificial saliva has been developed to solve this problem. Examples of artificial saliva include those containing hyaluronic acid (Patent Documents 1 to 4) and those containing a nonionic thickener (Patent Document 5).

  However, since the so-called artificial saliva is merely an artificial reproduction of saliva, it has a drawback of being dried immediately even if administered into the oral cavity. Therefore, a preparation specially applied to prevent oral dryness has been developed.

  For example, Patent Document 6 discloses a drug containing trimethylglycine (betaine) as a drug for alleviating symptoms of dry mucous membranes in the oral cavity or the like.

International Publication No. 2000/056344 Pamphlet JP 2007-269805 A JP 2007-269806 A JP 2007-291117 A Japanese Patent Laid-Open No. 6-145044 JP-T-2001-508423

  As described above, drugs that alleviate symptoms of dry mucous membranes in the oral cavity and the like have already been developed. However, with the aging of the population, the problem of dry mouth has become more prominent, and better moisture retention has been demanded. In addition, a preparation for suppressing dryness in the oral cavity is required to be spread evenly in the oral cavity, but after application, it must be difficult to sag in order to exert its action and effect in the application part.

  Therefore, the present invention has high moisturizing properties such that it can remarkably suppress dryness in the oral cavity by being applied in the oral cavity, and also has an appropriate viscosity while being excellent in spreadability and easy to spread. An object of the present invention is to provide an oral moisturizer having mutually contradictory properties that it is difficult to sag later.

  The inventors of the present invention have made extensive studies to solve the above problems. As a result, the present invention was completed by finding that an oral moisturizer exhibiting the above excellent characteristics can be obtained if trimethylglycine, polyacrylic acid salt and xanthan gum are used in combination.

  The oral moisturizer according to the present invention includes trimethylglycine, polyacrylate, and xanthan gum.

  As content of trimethylglycine in this invention formulation, 5.0 mass% or more and 15 mass% or less are suitable. If the said ratio is 5.0 mass% or more, the outstanding moisturizing effect will be exhibited more reliably. On the other hand, since the moisturizing effect of trimethylglycine reaches a peak and the bitterness of the preparation may appear even if the ratio is too large, the ratio is preferably 15% by mass or less.

  As the oral moisturizer of the present invention, those having a mass ratio of polyacrylate to xanthan gum of more than 1.0 and not more than 5.0 are suitable. Polyacrylates not only increase the viscosity of the preparation and suppress dripping after application, but also have the effect of significantly improving moisture retention by combining with trimethylglycine. In order to exhibit such an effect more effectively, it is preferable that the mass ratio of the polyacrylate to xanthan gum is more than 1.0. On the other hand, if the mass ratio is too large, the viscosity of the preparation becomes too high, and the effect of improving thixotropy by xanthan gum may not be sufficiently exhibited. Therefore, the mass ratio is preferably 5.0 or less.

  The total content of polyacrylate and xanthan gum in the preparation of the present invention is preferably 0.8% by mass or more and 3.0% by mass or less. When the total amount is within this range, the high moisture retention of the preparation of the present invention is more reliably exhibited.

  The content of xanthan gum in the preparation of the present invention is preferably 0.1% by mass or more and 1.0% by mass or less. If the ratio is 0.1% by mass or more, the combination with polyacrylate increases the thixotropy more reliably, and the formulation has an excellent characteristic that it is easily spread at the time of application but difficult to sag after application. It will be given enough. On the other hand, if the proportion is too large, a thin film may be formed when the preparation is dried. Therefore, the proportion is preferably 1.0% by mass or less.

  As content of polyacrylate in this invention formulation, 0.5 mass% or more and 2.0 mass% or less are suitable. The polyacrylate has an effect of increasing the viscosity of the preparation moderately to suppress dripping after application and significantly increasing the moisture retention by combining with trimethylglycine. If the ratio is 0.5% by mass or more, this effect is more reliably exhibited. However, if the ratio is too large, the viscosity of the preparation may be too high and it may be difficult to spread the formulation. Therefore, the ratio is preferably 2.0% by mass or less.

  The preparation of the present invention preferably contains no wetting agent or has a wetting agent content of 30% by mass or more. The wetting agent moisturizes the application area and also exhibits a moisturizing action, but the moisturizing property of the preparation of the present invention is mainly exerted by trimethylglycine, and the liquid wetting agent is probably the oral cavity. It is thought that it is due to depriving of moisture from the inner mucous membrane, but it is preferable that the preparation of the present invention does not contain a wetting agent because it may cause the oral mucosa to become rough, such as wrinkles generated as the preparation dries. However, the present inventors have shown that when a general liquid wetting agent is blended in an amount of 30% by mass or more, the moisture retention can be dramatically improved not only for a relatively short time but also for a long time of 4 hours or more. It is clarified by knowledge.

  The oral preparation according to the present invention can effectively suppress drying and moisturize by applying it to the oral cavity. Further, the preparation of the present invention has an appropriate viscosity and is easily spread in the oral cavity. On the other hand, preparations with excellent spreadability generally have a low viscosity, and after application, the amount of the preparation on the side surface in particular decreases, and there is a drawback that drying in that part proceeds. The inventive preparation has high thixotropic properties and does not sag after application.

  Therefore, the intraoral preparation according to the present invention is very useful as an agent capable of effectively suppressing dryness in the oral cavity, such as an elderly person with a small amount of saliva secretion or a bedridden patient who cannot close his / her mouth.

FIG. 1 is a graph showing the results of testing thixotropic properties of the preparation of the present invention and other preparations. FIG. 2 shows the results of testing the moisturizing properties of a preparation containing trimethylglycine as a humectant and containing a combination of sodium polyacrylate and xanthan gum as a thickener and a combination containing carboxyvinyl polymer and xanthan gum. It is a graph to show. FIG. 3 shows a preparation containing trimethylglycine as a humectant, which contains a combination of sodium polyacrylate and xanthan gum as a thickener, and the application of the preparation with various ratios of sodium polyacrylate and xanthan gum It is a graph which shows the result of having tested the moisture retention property after 10 minutes. FIG. 4 shows a preparation containing trimethylglycine as a humectant, which contains a combination of sodium polyacrylate and xanthan gum as a thickener, and the application of the preparation with various ratios of sodium polyacrylate and xanthan gum It is a graph which shows the result of having tested the moisture retention after 40 minutes.

  The oral moisturizer according to the present invention includes trimethylglycine, polyacrylate, and xanthan gum.

  Trimethylglycine is a bipolar compound in which the amino group of glycine is methylated to form a trimethylammonium group, and imparts high moisturizing properties to the preparation of the present invention and hardly damages the oral mucosa.

  The blending amount of trimethylglycine is preferably 5.0% by mass or more and 15% by mass or less with respect to the whole preparation. If the said ratio is 5.0 mass% or more, the outstanding moisturizing effect will be exhibited more reliably. On the other hand, since the moisturizing effect of trimethylglycine reaches a peak and the bitterness of the preparation may appear even if the ratio is too large, the ratio is preferably 15% by mass or less. As the said ratio, 6.0 mass% or more is more preferable, and 10 mass% or less is more preferable. If the said ratio shall be 10 mass% or less, the bitter taste derived from trimethylglycine can be suppressed more effectively. Since the preparation of the present invention is applied to the oral cavity, the taste is important.

  The polyacrylate is a salt of an acrylic acid polymer. In the present invention, the viscosity of the preparation is increased, and in addition to imparting thixotropy to the preparation by combination with xanthan gum, the moisture retention by trimethylglycine is further increased. Use for.

  The type of polyacrylate is not particularly limited, and examples thereof include sodium polyacrylate, potassium polyacrylate, calcium polyacrylate, and magnesium polyacrylate. In these, general sodium polyacrylate is used suitably as a thickener.

  The molecular weight of the polyacrylate is not particularly limited, and for example, those having a number average molecular weight of 10,000 or more and 200,000 or less can be used. If the number average molecular weight is 10,000 or more, the viscosity of the preparation can be increased moderately. On the other hand, if the molecular weight is too large, it may be difficult to dissolve in a solvent, so the molecular weight is preferably 200,000 or less. The number average molecular weight is more preferably 20,000 or more and 150,000 or less, and further preferably 30,000 or more and 100,000 or less. The molecular weight distribution is preferably 5,000 or more and 1,000,000 or less, more preferably 10,000 or more and 500,000 or less, and further preferably 20,000 or more and 200,000 or less.

  Polyacrylic acid salts may be either cross-linked or non-cross-linked, but they not only increase the viscosity of the formulation more effectively, but also retain moisture molecules in a three-dimensional network structure. From the viewpoint of further improvement, and from the viewpoint of reducing stringing even when the viscosity of the preparation is increased, a crosslinked polyacrylic acid salt is more preferable.

Examples of the crosslinked polyacrylic acid include those obtained by intermolecular crosslinking of the carboxyl group of polyacrylic acid with a C _1-6 alkylene diol or a general diepoxy crosslinking agent. As the C _1-6 alkylene diol, ethylene glycol or propylene glycol is preferably used. In addition, as the diepoxy crosslinking agent, linear aliphatic diglycidyl ether such as ethylene glycol diglycidyl ether and diethylene glycol diglycidyl ether; cyclic aliphatic diglycidyl ether such as 2,2-bis (4-hydroxycyclohexyl) propane diglycidyl ether Examples include glycidyl ethers; aromatic diglycidyl ethers such as bis (4-hydroxyphenyl) methane diglycidyl ether. Note that not all carboxy side chains react even if an excessive amount of the crosslinking agent is used, but in order to ensure the water solubility of the crosslinked polyacrylate, the degree of crosslinking is the amount of crosslinking agent relative to polyacrylic acid. It is preferable to adjust by.

  The blending amount of the polyacrylate is preferably 0.5% by mass or more and 2.0% by mass or less with respect to the whole preparation. If the said ratio is 0.5 mass% or more, the viscosity of a formulation will increase moderately and the moisturizing effect and the thixotropic improvement effect will be more reliably exhibited. However, if the ratio is too large, the viscosity of the preparation may be too high and it may be difficult to spread the formulation. Therefore, the ratio is preferably 2.0% by mass or less. As the said ratio, 0.7 mass% or more is more preferable, 0.8 mass% or more is more preferable, 1.5 mass% or less is more preferable, 1.2 mass% or less is further more preferable.

  Xanthan gum is a polysaccharide composed of repeating units composed of 2 molecules of glucose, 2 molecules of mannose, and 1 molecule of glucuronic acid, and the main chain composed of glucose linked by β-1,4 bonds between the 2 molecules of mannose. It has a structure in which side chains sandwiched with glucuronic acid are bonded. Xanthan gum is obtained by fermentation using specific bacteria. The molecular weight of xanthan gum is said to be about 2 million, possibly 13 to 50 million depending on the state of association. In the present invention, the type of xanthan gum is not particularly limited, and commercially available products can be used.

  Xanthan gum acts as a thickening agent in combination with a polyacrylate and imparts an appropriate viscosity to the preparation, and also has an effect of imparting thixotropic properties.

  The blending amount of xanthan gum is preferably 0.1% by mass or more and 1.5% by mass or less with respect to the whole preparation. If the ratio is 0.1% by mass or more, the combination with polyacrylate increases the thixotropy more reliably, and the formulation has an excellent characteristic that it is easily spread at the time of application but difficult to sag after application. It will be given enough. On the other hand, if the proportion is too large, a thin film may be formed when the preparation is dried. Therefore, the proportion is preferably 1.5% by mass or less. As the said ratio, 0.2 mass% or more is more preferable, 0.4 mass% or more is further more preferable, 1.2 mass% or less is more preferable, 1.0 mass% or less is further more preferable, 0.7% A mass% or less is particularly preferred.

  The total content of the polyacrylate and the xanthan gum in the preparation of the present invention may be appropriately adjusted within a range that makes the viscosity of the preparation moderate, but preferably 0.8% by mass or more and 3.0% by mass. % Or less is preferable. When the total amount is within this range, the high moisture retention of the preparation of the present invention is more reliably exhibited. As the said value, 1.0 mass% or more is more preferable, 1.2 mass% or more is further more preferable, 2.5 mass% or less is more preferable, and 2.0 mass% or less is further more preferable.

  As a relative amount of xanthan gum and polyacrylate, the mass ratio of polyacrylate to xanthan gum is preferably more than 1.0 and 5.0 or less. Polyacrylates not only increase the viscosity of the preparation and suppress dripping after application, but also have the effect of significantly improving moisture retention by combining with trimethylglycine. In order to exhibit such an effect more effectively, it is preferable that the mass ratio of the polyacrylate to xanthan gum is more than 1.0. On the other hand, if the mass ratio is too large, the viscosity of the preparation becomes too high, and the effect of improving thixotropy by xanthan gum may not be sufficiently exhibited. Therefore, the mass ratio is preferably 5.0 or less. The ratio is more preferably 1.2 or more, further preferably 1.5 or more, more preferably 4.0 or less, still more preferably 3.0 or less, and particularly preferably 2.5 or less.

  The oral moisturizer according to the present invention contains trimethylglycine as a moisturizer component, and includes a combination of polyacrylate and xanthan gum as a so-called thickener, but also contains components common to oral preparations for oral use. It may be.

  For example, pH adjusters such as triethanolamine, citric acid and malic acid; medicinal properties such as hinokitiol, glycyrrhizinate, cetylpyridinium salt; benzoate, p-oxybenzoate, cetylpyridinium salt, glycine compound, etc. Preservatives; sweeteners such as sucrose, oligosaccharides, aspartame, saccharin, trehalose, xylitol, erythritol, glucose; other moisturizing ingredients such as sodium hyaluronate, protamine, suizendinori; Can be used.

  The oral moisturizer according to the present invention preferably contains water as a solvent. The type of water is not particularly limited, and distilled water, purified water, pure water, ultrapure water, tap water, well water, and the like can be used, but since there are few impurities and relatively low cost, distilled water or It is preferable to use purified water.

  In the present invention, a so-called wetting agent is not added, or the wetting agent content is preferably 30% by mass or more. Here, the wetting agent is a water-miscible liquid having a relatively low molecular weight, and refers to a liquid that increases the fluidity of the preparation and prevents evaporation of water. For example, ethylene glycol, propylene glycol, glycerin, liquid polyethylene glycol And so on. As described above, the wetting agent moisturizes the application part and also exhibits a moisturizing action, but the moisturizing property of the preparation of the present invention is exhibited by trimethylglycine. In particular, within a relatively short time of about 1 to 1.5 hours after application, a general wetting agent is not necessary even under conditions that facilitate drying, and trimethylglycine is sufficient. In addition, when a general liquid wetting agent is blended at a low concentration of more than 0% by mass and less than 30% by mass, moisture retention is considered to be possibly caused by depriving moisture from the oral mucosa. On the contrary, when a general liquid wetting agent is blended in an amount of 30% by mass or more, the moisture retention can be dramatically improved not only for a relatively short time but also for a long time of 4 hours or more. Therefore, the preparation of the present invention does not contain a wetting agent, or the content thereof should be 30% by mass or more.

  Moreover, since this invention formulation prevents drying by apply | coating to an intraoral mucosa, it shall not contain an abrasive | polishing agent like a dentifrice.

  The production method of the oral moisturizer according to the present invention is not particularly limited, and each component may be dissolved or suspended in water as a solvent. However, adding polyacrylate and xanthan gum may increase the viscosity of the solution and make it difficult to stir, so first prepare an aqueous solution of components other than polyacrylate and xanthan gum, then polyacrylate and xanthan gum It is preferable to add and sufficiently stir. Moreover, since the pH of a formulation changes with addition of polyacrylate and xanthan gum, when adding a pH adjuster, it is preferable to add and adjust pH finally.

The oral moisturizer according to the present invention can effectively suppress drying in the oral cavity by applying it to the oral cavity. The application amount may be appropriately adjusted according to the age and symptoms of the person to be applied. For example, about 10 mg / cm ² or more and 50 mg / cm ² or less per dose, about 2 hours or more and about 12 hours or less. It may be applied evenly in the oral cavity at intervals.

  The oral moisturizer according to the present invention exhibits an excellent moisturizing effect and has high thixotropy. Therefore, the oral moisturizing agent is easy to spread at the time of application, but hardly drops after application. Therefore, the oral moisturizing agent according to the present invention is a highly convenient preparation that does not need to partially reduce the application interval because the preparation is unevenly distributed due to dripping, such as a low-viscosity preparation that is easy to spread but easy to sag. It can be said.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited by the following examples, but may be appropriately modified within a range that can meet the purpose described above and below. Of course, it is possible to implement them, and they are all included in the technical scope of the present invention.

  Unless otherwise specified, “%” indicates mass%.

Examples 1 to 6 Production of the preparation of the present invention 8.0% trimethylglycine, cross-linked sodium polyacrylate (manufactured by Toagosei Co., Ltd., product name “Leogic (registered trademark) 260H”, molecular weight distribution: 30000 to 100,000, cross-linked Degree: 1.0%) 1.0% or 1.5%, xanthan gum (manufactured by Sanki Co., Ltd., product name “Celtrol (registered trademark) CG-T”, average molecular weight: 2,000,000 (catalog value) Formulations containing 0.5), 1.0% or 1.5%) and other ingredients as shown in Table 1 were prepared. More specifically, components other than polyacrylate, xanthan gum and citric acid were completely dissolved by adding them to purified water or distilled water heated to 60 to 80 ° C. and stirring. Polyacrylate and xanthan gum were added to the obtained solution and stirred. After a uniform solution was obtained, citric acid was added little by little while confirming the pH to neutralize the solution.
In the following tables and figures, sodium polyacrylate is abbreviated as “PAA”, carboxyvinyl polymer as “CVP”, sodium alginate as “AA”, and cetylpyridinium hydrochloride as “CPC”.

Comparative Examples 1-14
In the said Examples 1-6, the carboxy vinyl polymer or sodium alginate was used instead of the sodium polyacrylate, or the formulation which does not mix | blend a xanthan gum was similarly prepared according to the prescription shown in Table 2.

Test Example 1 Measurement of thixotropy index It is preferable that the oral preparation has a characteristic that it is easy to spread but difficult to sag after application. Here, there is a property of thixotropy that the viscosity decreases when subjected to a shearing force, and the viscosity increases when stationary. That is, in the case of an intraoral preparation exhibiting thixotropic properties, it can be said that the viscosity decreases during application and spreads easily, and the viscosity increases after application and hardly droops. Therefore, for each preparation, the apparent viscosity at different shear rates (rotational speeds) was measured according to JIS K6833-1 (2008), and the ratio (thixotropic index) was calculated to evaluate thixotropic properties.

Specifically, the temperature of the plate rotor of the viscoelasticity measuring apparatus (product name “RS600” manufactured by Eihiro Sangyo Co., Ltd.) was set to 37 ° C., and the gap between the plate and rotor was set to 52 μm. Each sample (about 1 g) was placed on a plate, lightly leveled with a spoon, and then sandwiched with a rotor. Viscoelasticity was measured when the rotor was rotated at a rotational speed of 2.5 S ^-1 or 25.0 S ^-1 for 30 seconds. The measurement results were analyzed with dedicated software, and the ratio of both measured values was calculated. The results are shown in Table 3 and FIG.

  As shown in Table 3 and FIG. 1, when sodium alginate is blended as a thickener, the value of the thixotropy index is small, that is, the viscosity ratio is small when the shear force is large and small. Therefore, it is considered that it is difficult to sag after application, but it is difficult to spread or it is easy to sag after application. Moreover, when xanthan gum was not blended as a thickener, thixotropic properties were sometimes not sufficient.

  On the other hand, formulations containing carboxyvinyl polymer or sodium polyacrylate together with xanthan gum as a thickener are excellent in thixotropic properties, and have excellent characteristics that they are difficult to sag after application even though they are easy to spread during application. It was proved that.

  In addition, the concentration of carboxyvinyl polymer (CVP) and sodium polyacrylate (PAA) is different because, when combined with xanthan gum, the carboxyvinyl polymer has a lower concentration and the formulation hardness increases. This is a result of roughly adjusting the hardness of each preparation after measuring the storage elastic modulus as a standard of hardness with a mixture of carboxyvinyl polymer and xanthan gum, sodium polyacrylate and xanthan gum. That is, the result of the preparation containing 0.3% of carboxyvinyl polymer is a preparation containing 1.0% of sodium polyacrylate, and the result of preparation containing 0.5% of carboxyvinyl polymer is 1.5% of sodium polyacrylate. It can be compared with the formulation containing.

Test Example 2 Moisturizing test 1
In order to evaluate the moisture retention of the preparation of the present invention, a preparation containing sodium polyacrylate (PAA) and xanthan gum (XAN) and a carboxyvinyl polymer ( A formulation comprising CVP) and xanthan gum (XAN) was prepared.

Next, the moisture retention of each of the above preparations was tested. Specifically, after setting a constant temperature and humidity chamber (TBE-3HM2GEF manufactured by Tabai Espec Co., Ltd.) at 30 ° C. and 30% RH, a tray was arranged in the room, and a pig tongue was placed thereon. After 10 minutes, 0.5 g of each formulation was applied on the porcine tongue. Moisture was measured using a moisture meter (manufactured by LIFE, Moisture Checker Mocus) every 10 minutes after application. Moisture measurement was performed by placing the pig tongue on the weighing scale and reading the indicated value when the moisture meter was pressed parallel to the tongue surface so that the measured value was 200 ± 20 g. . In addition, according to the instruction | indication of a moisture meter, the relationship between an instruction | indication value and a state is as follows.
30 or more-Normal 29 or more, less than 30-Boundary 27 or more, less than 29-Slightly dry 25 or more, less than 27-Moderate drying Less than 25-Highly dry

  The results are shown in FIG. As shown in FIG. 2, the combination of sodium polyacrylate (PAA) and xanthan gum (XAN) in combination with carboxyvinyl polymer (CVP) and xanthan gum (XAN) has a higher moisturizing property. A high result was obtained. Further, as in Test Example 1 above, in terms of the hardness of the preparation, the preparation containing 0.5% carboxyvinyl polymer is equivalent to the preparation containing 1.5% sodium polyacrylate, and the polyacrylic used in the test Although the proportion of sodium polyacrylate in the combination of sodium acid (PAA) and xanthan gum (XAN) is lower than that of the combination of carboxyvinyl polymer (CVP) and xanthan gum (XAN) Moisture retention is shown.

  Therefore, it became clear that the combination of sodium polyacrylate (PAA) and xanthan gum (XAN) is very useful in terms of the moisturizing property of the preparation containing trimethylglycine as a humectant.

Test Example 3 Moisturizing test 2
In order to test the ratio and moisturizing properties of sodium polyacrylate (PAA) and xanthan gum (XAN) in an oral moisturizer containing trimethylglycine as a moisturizer, the formulation shown in Table 5 was used in the same manner as in Example 1 above. A formulation was prepared. In addition, the value in a table | surface shows the mass%.

  Each of the above preparations was tested for moisture retention under the same conditions as in Test Example 2. The results after 10 minutes from the application of each preparation are shown in FIG. 3, and the results after 40 minutes are shown in FIG.

  As shown in FIGS. 3 to 4, there was no difference in moisture retention between the preparations 10 minutes after application of the preparations, and the indicated value was maintained at approximately 25 or more even after 40 minutes. Thus, it was shown that the oral moisturizer according to the present invention has extremely excellent moisturizing properties.

Test Example 4 Moisturizing test 3
Furthermore, studies on sodium polyacrylate and xanthan gum, which are important components of the preparation of the present invention, were advanced. Specifically, first, a preparation was prepared by the same method as in Example 1 with the formulation shown in Table 6. In addition, the value of each component in a table | surface shows the mass%.

  About the preparation obtained above and a part of the preparation tested in Test Example 3, the moisture retention 40 minutes after application of each preparation was measured under the same conditions as in Test Example 2. The results are shown in Table 7.

  As described above, the total content of polyacrylate and xanthan gum is 0.8% by mass or more with respect to the whole preparation, and the mass ratio of polyacrylate to xanthan gum is more than 1.0. In some cases, it was revealed that high moisture retention such that the indicated value exceeds 25 was obtained even after 40 minutes from application.

Test Example 5 Moisturizing test 4
A formulation was prepared in the same manner as in Example 1 with the formulation shown in Table 8.

  About the formulation obtained above, the moisture retention 10 minutes and 40 minutes after application of each formulation was measured under the same conditions as in Test Example 2 above. The results are shown in Table 9.

  According to the results of Test Examples 1 to 5 shown above, the preparation of the present invention containing trimethylglycine, polyacrylate, and xanthan gum is excellent in moisture retention regardless of the medicinal component, and spreadability and application when applied. It was experimentally proved to have a moderate viscosity later.

Test Example 6 Moisturizing test 5
As shown in Table 10, a preparation was prepared by the same method as in Example 1 except that the concentration of trimethylglycine in the preparation J was changed from 4.0% by mass to 20.0% by mass.

  For the preparations obtained above, the moisture retention was measured 10 minutes, 40 minutes and 80 minutes after application of each preparation under the same conditions as in Test Example 2 above. The results are shown in Table 11.

  As shown in the above results, it was found that the optimum concentration of trimethylglycine is 8.0% by mass.

Test Example 7 Moisturizing test 6
As shown in Table 12, by the same method as in Example 1, the concentration of trimethylglycine was fixed in the formulation J, and a formulation in which glycerin was blended in the range of 5.0% by mass to 30.0% by mass was prepared. .

  With respect to the preparation obtained above, the moisture retention after 10 minutes, 40 minutes, 80 minutes and 120 minutes after application of each preparation was measured under the same conditions as in Test Example 2. In addition, about the formulation J, it measured again. The results are shown in Table 13.

  As shown in the above results, when 120 minutes have elapsed, it is clear that the humectant action is enhanced by adding a relatively high concentration of glycerin, which is a general liquid wetting agent, specifically up to 30.0% by mass. became.

Claims (7)

  An oral moisturizer comprising trimethylglycine, polyacrylate and xanthan gum.   The oral moisturizer according to claim 1, wherein the content of trimethylglycine is 5.0 mass% or more and 15 mass% or less with respect to the whole preparation.   The oral moisturizer according to claim 1 or 2, wherein a mass ratio of polyacrylate to xanthan gum is more than 1.0 and 5.0 or less.   The oral moisturizer according to any one of claims 1 to 3, wherein a total content of the polyacrylate and the xanthan gum is 0.8% by mass or more and 3.0% by mass or less with respect to the whole preparation.   The oral moisturizer according to any one of claims 1 to 4, wherein the xanthan gum content is 0.1% by mass or more and 1.0% by mass or less with respect to the whole preparation.   The oral moisturizer according to any one of claims 1 to 5, wherein the content of the polyacrylate is 0.5% by mass or more and 2.0% by mass or less with respect to the whole preparation.   The moisturizer according to any one of claims 1 to 6, which does not contain a humectant or has a humectant content of 30% by mass or more.