JP2009149540A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dentifrice composition that has excellent dispersibility in the oral cavity, foam durability and sense of use, hardly causes a change in color during preservation and has excellent storage stability with time. <P>SOLUTION: The dentifrice composition is obtained by mixing (A) 1.0-3.0 mass% of xanthan gum with (B) 0.5-2.5 mass% of a polyvinylpyrrolidone in the total amount of (A) and (B) of 2.0-4.0 mass% and using an alkyl sulfate, sorbitol and titanium oxide. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a dentifrice composition that is excellent in oral dispersibility and foam persistence during tooth brushing, has a good feeling of use, and has excellent storage stability over time.

  Of the feeling of use of the dentifrice composition, the feeling of foam in the oral cavity is one of the textures that can feel a feeling of cleaning. However, saliva is always secreted in the oral cavity, and if the teeth are brushed for a long time, the dentifrice is diluted with the saliva, so that the bubbles do not last and the cleaning feeling is reduced.

  A dentifrice composition containing polyvinylpyrrolidone, fatty acid diethanolamide or polyoxyethylene hydrogenated castor oil and an alkyl sulfate has been proposed as a technique for retaining foam in the oral cavity for a long time (see Patent Document 1).

  However, in recent years, with the growing awareness of oral self-care in the home, such as carefully polishing the gap between teeth and the boundary between teeth and gums, a dentifrice composition with better dispersibility in the oral cavity and sustained feeling of foam is required. ing.

JP 11-209255 A JP 2000-26259 A JP 2002-302428 A JP 2000-63249 A

  The present invention has been made in view of the above circumstances, and provides a dentifrice composition that is excellent in dispersibility in the oral cavity at the time of toothbrushing and foam sustainability, has a good feeling of use, and has good storage stability over time. With the goal.

  As a result of intensive studies to achieve the above object, the present inventors have determined that (A) xanthan gum and (B) polyvinyl pyrrolidone, (A) component is 1.0 to 3.0% (mass%, the same applies hereinafter). ), (B) component is blended at 0.5 to 2.5%, and (A) and (B) components are combined at 2.0 to 4.0%, and alkyl sulfate, sorbit, By combining with titanium oxide, a dentifrice composition that has surprisingly excellent dispersibility in the mouth during brushing, excellent foam persistence, little discoloration over time, and excellent storage stability. It was found that it was obtained, and the present invention was made.

  As described above, xanthan gum, polyvinyl pyrrolidone, sorbit, and alkyl sulfate are widely used as compounding components of dentifrice compositions, and the compounding compositions are also described in Patent Documents 2 to 4, which are related to the present invention. There is no technical idea that the above ingredients can be combined at a specific ratio to combine excellent oral dispersibility, foam persistence, and storage stability over time. As will be apparent from the examples described below, when not satisfying any of the essential requirements of the present invention, it can have excellent oral dispersibility, foam persistence and stability over time after storage at medium and high temperatures. Therefore, the object of the present invention cannot be achieved.

  Accordingly, the present invention provides (A) xanthan gum and (B) polyvinylpyrrolidone, wherein (A) component is 1.0-3.0%, (B) component is 0.5-2.5%, and (A) And (B) a dentifrice composition comprising a combination of components in a range of 2.0 to 4.0%, and a combination of an alkyl sulfate, sorbit and titanium oxide. provide.

  The dentifrice composition of the present invention is excellent in oral dispersibility and foam persistence, has an excellent feeling of use, hardly undergoes discoloration during storage, and has excellent storage stability over time.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is prepared as a dentifrice such as a toothpaste, a liquid dentifrice, a liquid dentifrice, particularly a toothpaste, and contains xanthan gum, polyvinyl pyrrolidone, alkyl sulfate, sorbit, and titanium oxide as essential components.

  (A) As xanthan gum, a commercially available product can be used, for example, Novazan manufactured by ADM Far East Co., Ltd., Monart Gum DA manufactured by Kelco Co., Kelzan T, Keldent, Echo Gum manufactured by Dainippon Pharmaceutical Co., Ltd. Is mentioned.

  The compounding quantity of a xanthan gum is 1.0-3.0% of the whole composition, Preferably it is 1.5-2.8%. If the blending amount is less than 1.0%, sufficient foam sustaining effect is not exhibited, and if it exceeds 3.0%, dispersibility in the oral cavity may be deteriorated.

(B) As polyvinylpyrrolidone, the thing of a weight average molecular weight 10,000-1500,000, especially 30,000-1,300,000 is preferable. When the weight average molecular weight is less than 10,000, the foam persistence may not be sufficiently exhibited. When the weight average molecular weight exceeds 1,500,000, the dispersibility in the oral cavity is deteriorated or the spinnability is generated. May be inferior. Polyvinylpyrrolidone may be used alone or in combination of two or more.
The weight average molecular weight is obtained by converting the K value defined in USP into the weight average molecular weight measured by the light scattering method.

  Commercially available products can be used as the polyvinyl pyrrolidone, such as Rubiscol K30 (weight average molecular weight of about 40,000) and Rubiscol K90 (weight average molecular weight of about 1,200,000) manufactured by BASF Japan. It is done.

  The compounding quantity of polyvinylpyrrolidone is 0.5 to 2.5% of the whole composition, Preferably it is 0.8 to 2.0%. If the blending amount is less than 0.5%, a sufficient foam sustaining effect is not exhibited, and if it exceeds 2.5%, the discomfort in the oral cavity may be deteriorated and the feeling of use may be deteriorated.

  In the composition of the present invention, the total content of (A) xanthan gum and (B) polyvinyl pyrrolidone is 2.0 to 4.0%, preferably 2.5 to 4.0%. It is effective for satisfying the internal dispersibility and the foam lasting effect. If the total content is less than 2.0%, the foam persistence is poor, and if it exceeds 4.0%, the dispersibility in the oral cavity becomes poor, and the dentifrice becomes hard and the usability deteriorates.

  Next, alkyl sulfates having 8 to 18 carbon atoms, particularly 12 to 14 carbon atoms are suitable, and alkali metal salts such as sodium salts and potassium salts are used. If the alkyl group has less than 8 carbon atoms, irritation may be felt during use or the taste may be poor, and if it exceeds 18, the stability of the preparation such as liquid separation may be poor.

  Specific examples of the alkyl sulfate include potassium lauryl sulfate, sodium lauryl sulfate, triethanolamine lauryl sulfate, sodium myristyl sulfate, sodium cetyl sulfate and the like, and particularly sodium lauryl sulfate ( Toho Chemical Industries, Ltd., Nikko Chemicals, etc.) are preferred.

  The compounding amount of the alkyl sulfate is preferably 0.5 to 2.5%, particularly preferably 0.8 to 2.0% of the entire composition. If the blending amount is less than 0.5%, foaming is weak and the polishing comfort may be inferior, and if it exceeds 2.5%, the feeling of use may be worsened such as irritation in the oral cavity.

  Sorbit is not particularly limited as long as it can be usually used in a dentifrice composition, and a commercially available product can be used. For example, NEOSORB70 / 02SB manufactured by Rocket Co., Ltd., D-sorbitol solution manufactured by Towa Kasei Kogyo Co., Ltd. and the like can be mentioned.

  The blending amount of sorbit is preferably 15 to 45%, particularly preferably 20 to 35% of the whole composition in terms of pure content. If the blending amount is less than 15%, the foam sustaining effect may be lowered, and if it exceeds 45%, dispersibility may be deteriorated, and discoloration may deteriorate with time.

  Titanium oxide is not particularly limited as long as it can be usually used in a dentifrice composition, and a commercially available product can be used. An example is TIPAQUE CR-50 manufactured by Ishihara Sangyo Co., Ltd.

  The compounding amount of titanium oxide is preferably 0.1 to 2%, particularly preferably 0.5 to 1% of the entire composition. If the blending amount is less than 0.1%, discoloration may occur and stability with time may be inferior. . In the present invention, it is considered that by adding titanium oxide, it is possible to prevent discoloration over time during storage due to the coating effect or the action derived from titanium.

  In the dentifrice composition of the present invention, in addition to the above-described components, various other components that are usually used in dentifrice compositions can be blended as optional components as long as the effects of the present invention are not impaired. Examples of other components that can be blended include binders, surfactants, abrasives, thickeners, sweeteners, fragrances, pH adjusters, active ingredients or medicinal ingredients, and preservatives.

As the binder, in addition to xanthan gum and polyvinylpyrrolidone, other binders such as carrageenan, methylcellulose, sodium hydroxyethylcellulose, sodium alginate, tragacanth gum, caraya gum, arabiya gum, locust bean gum, polyvinyl alcohol, sodium polyacrylate, Cross-linked sodium polyacrylate, carboxyvinyl polymer, carbopol, bee gum and the like can be blended.
When mix | blending another binder, the range which the sum total with the total amount of (A) xanthan gum and (B) polyvinyl alcohol becomes 2 to 5% of the whole composition is suitable.

  As the surfactant, in addition to the alkyl sulfate, other anionic surfactants, cationic surfactants, and nonionic surfactants can be blended.

Examples of anionic surfactants include sodium N-lauroyl sarcosinate other than alkyl sulfates, sodium N-myristoyl sarcosinate, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, α-olefin Examples thereof include N-acyl glutamates such as sodium sulfonate, sodium N-palmitoyl glutamate, and N-acyl taurates such as sodium N-methyl-N-acyl taurate.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.

  Nonionic surfactants include polyglycerin fatty acid esters, sucrose fatty acid esters, sucrose fatty acid esters such as maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters and lactol fatty acid esters, alkylol amides, polyoxy Polyoxyethylene sorbitan fatty acid ester such as ethylene sorbitan monostearate, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, fatty acid diethanolamide such as lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether , Polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, pluronic and the like.

  The other surfactant which is an optional component is preferably in a range in which the total blending amount with the alkyl sulfate is 0.5 to 5%, particularly 0.8 to 3% of the entire composition.

  As abrasives, dicalcium phosphate dihydrate and anhydrous salts, calcium phosphate compounds such as primary calcium phosphate, tertiary calcium phosphate and calcium pyrophosphate, silica compounds such as precipitated silica and aluminosilicate, calcium carbonate, water One or more of calcium oxide, aluminum hydroxide, aluminum silicate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite and the like can be blended. The blending amount of the abrasive is usually 0 to 50%, particularly 2 to 40% of the whole composition.

  As the thickener, in addition to sorbit, other thickeners such as glycerin, propylene glycol, polyethylene glycol having a weight average molecular weight of 200 to 6,000, ethylene glycol, 1,3-butylene glycol, reduced starch saccharified product, etc. Polyhydric alcohols other than sorbitol are mentioned, and one kind can be blended alone or two or more kinds can be combined. The blending amount is preferably in a range where the total blending amount with sorbit is 15 to 60% of the entire composition.

  Sweetening agents include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like. The blending amount of the sweetener is usually 0.01 to 5%.

  As fragrances, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange Oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, clove oil or eucalyptus oil. The compounding quantity to the composition of a fragrance | flavor can be 0.001-2%.

  Examples of the pH adjuster include organic acids such as citric acid, lactic acid, malic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate, and the like. .

  Medicinal or active ingredients include enzymes such as dextranase, amylase, protease, mutanase, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamins Inflammatory agents, antibacterial agents such as copper chlorophyll, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, triclosan, hinokitiol, lysozyme chloride, anticalculus agents such as polyphosphates such as water-soluble pyrophosphate, glycine, proline, etc. Of amino acids can be added.

  Examples of the preservative include paraoxybenzoic acid esters such as methylparaben, ethylparaben, propylparaben, and butylparaben, sodium benzoate, and the like.

  In addition, as optional components, sugar alcohols such as xylitol, mannitol, erythritol, inorganic compounds such as calcium hydrogen phosphate, zeolite, hydroxyapatite, granulated products thereof, granulated products of organic powders such as crystalline cellulose, Natural polymers such as agar, gelatin, starch, glucomannan, synthetic polymer compounds such as polyvinyl acetate, acrylic, polyurethane, polyester, polyamide, nylon, polyvinyl chloride and copolymers thereof, carnauba wax, rosin, Crosslinking and polymerization of waxes such as rice wax, microcrystalline wax, beeswax and paraffin wax, higher alcohols such as cetanol and stearyl alcohol, and latex rubbers such as polyisobutylene, polybutadiene, urethane, silicone and natural rubber Those obtained by molding or the like, or may be used or lame film those obtained by mixing these materials. Lame films include organic resin laminated film powder, laminated film powder in which a vapor deposition layer such as aluminum is introduced into the organic resin laminated film, specifically, polyethylene terephthalate / polymethyl methacrylate laminated film powder, polyethylene terephthalate・ Aluminum / epoxy laminated powder or the like can be blended within a range not impeding the effects of the present invention.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.
For sorbitol, sodium lauroylmethylalanine, and glycerin, the compounding amounts converted into pure components are shown in the table.

[Examples 1-15, Comparative Examples 1-13]
Dentifrice compositions having the compositions shown in Tables 1 and 2 were prepared by a conventional method, and oral dispersibility, foam persistence and stability over time (discoloration) were evaluated by the following methods. The results are shown in Tables 1 and 2. The raw materials used are as shown below.

<Oral dispersibility>
Evaluation was conducted by a sensory test using 10 professional panelists. 1 g of the test dentifrice composition filled in the laminate tube was extruded onto a toothbrush and brushed in the same manner as usual. The intraoral dispersibility of the test dentifrice composition in use was evaluated by Evaluation Criteria-1 shown below, and the average score of 10 people was shown by Evaluation Criteria-2. In addition, the dentifrice composition of the comparative example 13 was used for the control.

Evaluation criteria-1;
5 points: Dispersibility of the test dentifrice composition is considerably better than the control dentifrice composition 4 points: Dispersibility of the test dentifrice composition is better than the control dentifrice composition 3 points: Control dentifrice composition Dispersibility of the test dentifrice composition is comparable to the product 2 points: Dispersibility of the test dentifrice composition is poor compared to the control dentifrice composition 1 point: Test compared to the control dentifrice composition Dispersibility of the dentifrice composition is rather bad Evaluation Criteria-2;
◎: Average score of 10 people is 4.5 points or more ○: Average score of 10 people is 3.5 points or more and less than 4.5 points △: Average score of 10 people is 2.0 points or more to 3.5 points Less than ×: Average score of 10 people is less than 2.0

<Durability of foam>
Evaluation was conducted by a sensory test using 10 professional panelists. 1 g of the test dentifrice composition filled in the laminate tube was extruded onto a toothbrush and brushed in the same manner as usual. The persistence of the foam in the oral cavity after 2 minutes was evaluated by Evaluation Criteria-3 shown below, and the average score of 10 people was shown by Evaluation Criteria-4. In addition, the dentifrice composition of the comparative example 13 was used for the control.

Evaluation criteria-3;
5 points: The test dentifrice composition has significantly better foam persistence than the control dentifrice composition. 4 points: The test dentifrice composition has more foam persistence than the control dentifrice composition. Good 3 points: The foam persistence of the control dentifrice composition and the test dentifrice composition is the same 2 points: The test dentifrice composition has less foam persistence than the control dentifrice composition 1 point : Criterion -4 with significantly worse foam persistence for the test dentifrice composition compared to the control dentifrice composition;
◎: Average score of 10 people is 4.5 points or more ○: Average score of 10 people is 3.5 points or more and less than 4.5 points △: Average score of 10 people is 2.0 points or more to 3.5 points Less than ×: Average score of 10 people is less than 2.0

<Stability over time (discoloration)>
Discoloration of test dentifrice composition stored at 50 ° C. when stored in a thermostatic bath at 50 ° C. and −5 ° C. for 4 weeks after being stored in a thermostatic bath at 50 ° C. and −5 ° C. Was evaluated according to the following criteria using a test dentifrice composition stored at −5 ° C. as a control.

Evaluation criteria;
◎: No discoloration is observed △: Discoloration is observed ×: Significant discoloration is observed

＊１）ポリビニルピロリドン：ルビスコールＫ−３０（ＢＡＳＦ（株）製、重量平均分子量４０,０００）
＊２）ポリビニルピロリドン：ルビスコールＫ−９０（ＢＡＳＦ（株）製、重量平均分子量１,２００,０００）
＊３）ソルビットは、７０％水溶液のものを使用し、表中には純分換算した配合量を示した。

* 1) Polyvinylpyrrolidone: Rubiscol K-30 (BASF Corporation, weight average molecular weight 40,000)
* 2) Polyvinylpyrrolidone: Rubiscol K-90 (manufactured by BASF Corp., weight average molecular weight 1,200,000)
* 3) The sorbite used was a 70% aqueous solution, and the table shows the blended amount in terms of pure content.

Raw material xanthan gum: CP Kerco Co., Ltd. Monato Gum DA
Sodium lauryl sulfate; manufactured by Toho Chemical Industry Co., Ltd. sodium lauryl sulfate, sodium myristyl sulfate; manufactured by Nippon Chemicals Co., Ltd .; NIKOL SMS
Sorbit liquid (70%); Towa Kasei Kogyo Co., Ltd. D-sorbitol liquid titanium oxide; Ishihara Sangyo Co., Ltd .; TIPAQUE CR-50

＊１）ポリビニルピロリドン：ルビスコールＫ−３０（重量平均分子量４０,０００）
＊２）ラウロイルメチルアラニンナトリウムは、３０％水溶液のものを使用し、表中には純分換算した配合量で示した。
＊３）ソルビットは７０％水溶液を使用し、表中は純分換算した配合量である。
＊４）グリセリンは８５％水溶液を使用し、表中は純分換算した配合量である。

* 1) Polyvinylpyrrolidone: Rubiscol K-30 (weight average molecular weight 40,000)
* 2) Sodium lauroylmethylalanine was used in a 30% aqueous solution, and is shown in the table as a pure component.
* 3) Sorbite uses a 70% aqueous solution, and in the table, the compounding amount is in terms of pure content.
* 4) 85% aqueous solution of glycerin is used, and the amount in the table is a pure amount.

Raw material sodium carboxymethyl cellulose; CMC1260 manufactured by Daicel Chemical Industries, Ltd.
Sodium alginate; Kimika Algin N-lauroylmethyl taurine sodium manufactured by Kimika Co., Ltd .;
NIKKOL LMT manufactured by Nippon Chemicals Co., Ltd.
Sodium lauroylmethylalanine;
NIKKO Alaninate LN-30 manufactured by Nippon Chemicals Co., Ltd.
Glycerin (85%); Lion Oreo Chemical Co., Ltd. Dentifrice Glycerin

As can be seen from the results in Tables 1 and 2, if (A) xanthan gum or (B) polyvinylpyrrolidone is not blended, the foam persistence effect is poor, and the oral dispersibility is also poor (Comparative Examples 1 and 2), (A) If the blending amount of xanthan gum is less than 1.0%, sufficient foam sustaining effect cannot be obtained, and if it exceeds 3.0%, the foam persistence is improved, but the dispersibility in the oral cavity deteriorates, and the stability over time There was also a tendency to get worse (Comparative Examples 7, 8, and 13). (B) When the blending amount of polyvinylpyrrolidone is less than 0.5%, both the foam sustaining effect and the dispersibility in the oral cavity are not excellent, and when it exceeds 2.5%, the foam sustainability is poor (Comparative Example 9). 10, 13). In addition, when the total content of (A) xanthan gum and (B) polyvinyl pyrrolidone is less than 2.0%, the foam lasting effect is inferior, and when it exceeds 4.0%, both oral dispersibility and foam sustainability are poor. (Comparative Examples 11 and 12). Even if other anionic surfactants such as N-lauroylmethyl taurine sodium are not contained, it is not possible to obtain sufficient oral dispersibility and foam sustaining effect (Comparative Examples 3 and 4). ), When the sorbite was not included, the persistence of the foam was inferior (Comparative Example 5), and the dentifrice composition not containing titanium oxide was found to have a strong discoloration over time and inferior in storage stability (Comparative Example 6). 13).
For these, (A) xanthan gum and (B) polyvinylpyrrolidone, (A) component 1.0-3.0%, (B) component 0.5-2.5%, and (A) and (B) By mix | blending with the sum total of 2.0-4.0% of component, and using together an alkyl sulfate, sorbit, and a titanium oxide (Example), the dispersibility in the oral cavity at the time of toothpaste, and It was found that the durability of the foam was excellent, there was no discoloration over time, the storage stability was excellent, and the object of the present invention could be achieved.

Claims (2)

  (A) Xanthan gum and (B) polyvinylpyrrolidone, (A) component is 1.0-3.0 mass%, (B) component is 0.5-2.5 mass%, and (A) and (B) A dentifrice composition comprising a combination of components in a range of 2.0 to 4.0% by mass and a combination of alkyl sulfate, sorbit and titanium oxide.   (A) Xanthan gum is contained in an amount of 1.5 to 2.8% by mass, (B) polyvinylpyrrolidone is contained in an amount of 0.8 to 2.0% by mass, and the total of components (A) and (B) is 2.5 to 4. It is 0 mass%, 0.8 to 2.0 mass% of sodium lauryl sulfate, 20 to 35 mass% of sorbite in terms of pure content, and 0.5 to 1 mass% of titanium oxide are contained. Dentifrice composition.