WO2018221609A1 - Composition de dentifrice - Google Patents

Composition de dentifrice Download PDF

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Publication number
WO2018221609A1
WO2018221609A1 PCT/JP2018/020807 JP2018020807W WO2018221609A1 WO 2018221609 A1 WO2018221609 A1 WO 2018221609A1 JP 2018020807 W JP2018020807 W JP 2018020807W WO 2018221609 A1 WO2018221609 A1 WO 2018221609A1
Authority
WO
WIPO (PCT)
Prior art keywords
dentifrice composition
mass
sodium
dripping
points
Prior art date
Application number
PCT/JP2018/020807
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English (en)
Japanese (ja)
Inventor
清水　裕之
智史 畠田
Original Assignee
ライオン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライオン株式会社 filed Critical ライオン株式会社
Priority to KR1020197026231A priority Critical patent/KR20200011409A/ko
Priority to CN201880033257.3A priority patent/CN110650722A/zh
Publication of WO2018221609A1 publication Critical patent/WO2018221609A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Definitions

  • the present invention relates to a dentifrice composition that prevents dripping from the mouth when brushing teeth, provides a refreshing feeling, and is excellent in use feeling.
  • dripping of preparations such as dripping foam or dripping from the mouth not only reduces its effectiveness but is also easily recognized as an unpleasant feeling of use. It is also important to give an actual feeling that the mouth has been cleaned and refreshed after brushing.
  • a dentifrice composition usually contains a polishing agent, a surfactant, a wetting agent, a binder, and the like, and an anionic surfactant is foamed as a surfactant, and is used for ensuring cleaning properties and the like.
  • various water-soluble polymer substances are used as binders for the purpose of maintaining proper viscosity and shape retention.
  • JP-A-8-333228 JP-A-9-132517 Japanese Patent Laid-Open No. 11-1418 JP 2002-104945 A JP 2002-302450 A JP 2009-137908 A International Publication No. 2013/094312
  • the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition that prevents dripping from the mouth when brushing teeth, gives a refreshing feeling, and is excellent in use feeling.
  • the present inventors have formulated a specific amount or more of an anionic surfactant in a dentifrice composition, blended a specific amount or more of xanthan gum, and further added a bicarbonate.
  • an anionic surfactant in a dentifrice composition
  • blended a specific amount or more of xanthan gum
  • a bicarbonate When blended at a specific amount or less, it prevents foam or liquid from dripping from the mouth when brushing teeth, gives a refreshing feeling satisfactorily, and can suppress irritation moderately. It has been found that it can be imparted, and has led to the present invention.
  • polyacrylic acid sodium or sodium alginate was further mix
  • foam performance can be improved, dripping at the time of tooth brushing can be prevented, and at the same time a satisfactory refreshing feeling can be imparted. It can also be suppressed.
  • (A) an anionic surfactant is blended in a relatively large amount for the purpose of improving foaming, toothbrushing is started even if foaming can be improved.
  • bicarbonate has an effect of improving the feeling of use
  • (A) component is blended more than a specific amount and too much bicarbonate is blended, irritation becomes strong
  • (A), (B) and (C) By combining each of the three components (C) in specific amounts, surprisingly both the prevention of dripping and the provision of a refreshing feeling can be achieved, and the feeling of use can be improved, and an exceptional effect can be imparted.
  • xanthan gum that may affect spinnability as a binder is often used in an amount of less than 1% by mass, but in the present invention, xanthan gum is used in an amount of 1.4% by mass or more.
  • blended (A), (B) and (C) component of this invention is 1 minute after the start of toothpaste, Furthermore, more than 2 minutes passed. In addition, the dripping from the mouth was suppressed, the dripping was excellent, and the refreshing feeling and lack of irritation were also excellent.
  • the blending amount is inappropriate. The effect of the present invention was inferior.
  • the present invention provides the following dentifrice composition.
  • a dentifrice composition containing [2] (A) Dentifrice composition as described in [1] whose component is an anionic surfactant containing a sulfonic acid group. [3] (C) The dentifrice composition according to [1] or [2], wherein the bicarbonate is sodium bicarbonate and the content thereof is 0.1 to 3% by mass.
  • a dentifrice composition that prevents dripping from the mouth during tooth brushing, gives a refreshing feeling, and is excellent in use feeling.
  • the dentifrice composition of the present invention contains (A) an anionic surfactant, (B) xanthan gum, and (C) a bicarbonate in specific amounts.
  • Anionic surfactants include N-acyl such as alkyl sulfate, ⁇ -olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-methyl-N-acyl taurate, etc.
  • Examples include acyl amino acid salts such as taurate, acyl sarcosine salts, and N-acyl-L-glutamate. These can be used alone or in combination of two or more.
  • anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of foaming, and alkyl sulfates and ⁇ -olefin sulfonates are more preferable.
  • the salt examples include sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.
  • the alkyl sulfate the alkyl group preferably has 10 to 14 carbon atoms.
  • Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
  • alkali metal salts such as sodium and potassium of ⁇ -olefin sulfonate having 14 to 16 carbon atoms can be used, and among them, ⁇ -olefin sulfonate having 14 carbon atoms, particularly sodium.
  • Salts (generic name; sodium tetradecene sulfonate) are preferred.
  • Commercially available products that can be used for oral preparations can be obtained.
  • “K Liporan PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
  • anionic surfactants having no sulfonic acid group may have weak foaming when combined with the components (B) and (C).
  • anionic surfactants containing a sulfonic acid group as the component (A), particularly alkyl sulfates and ⁇ -olefin sulfonates are preferred.
  • the compounding amount of the anionic surfactant is 1.4 to 2.5% (mass%, the same applies hereinafter) of the whole composition, and preferably 1.6 to 2.0%. If the blending amount is less than 1.4%, foaming is reduced, the lack of dripping is inferior, and the refreshing feeling is inferior. When it exceeds 2.5%, the stimulation becomes stronger.
  • each compounding quantity range of the anionic surfactant mentioned above may be the same as the above.
  • the compounding amount of xanthan gum is 1.4 to 2.5% of the total composition, preferably 1.5 to 2.0%, more preferably 1.6 to 2.0%. If the blending amount is less than 1.4%, dripping cannot be prevented continuously, and the lack of dripping is inferior. When it exceeds 2.5%, the refreshing feeling is lowered. In addition, the preparation becomes too hard and the usability deteriorates.
  • (A) / (B) showing the blending ratio of (A) anionic surfactant and (B) xanthan gum is preferably 0.7 to 1.7, more preferably 0.9 to 1. 3. Within this range, dripping can be further prevented, a refreshing feeling can be further improved, and stimulation can be further suppressed. If it is less than 0.7, the refreshing feeling may be insufficient, and if it exceeds 1.7, dripping may not be sufficiently prevented or irritation may be increased.
  • (C) Sodium bicarbonate can be used as the bicarbonate.
  • the blending amount of (C) bicarbonate is 0.1 to 5% of the entire composition, preferably 0.1 to 3%, more preferably 0.3 to 2%, and still more preferably 0.3 to 1%. If it is less than 0.1%, the feeling of refreshing is insufficient, and if it exceeds 5%, irritation and discomfort may become strong, and dripping may not be sufficiently prevented.
  • component (D) sodium polyacrylate and / or sodium alginate.
  • component (D) may be either sodium polyacrylate or sodium alginate, but both may be used together in terms of effect.
  • the blending amount of component (D) is preferably 0.1 to 1%, more preferably 0.3 to 1% of the entire composition. If it is 0.1% or more, dispersibility in the oral cavity is sufficiently improved. If it exceeds 1%, the preparation may become too hard.
  • (B) / (D) indicating the blending ratio of (B) xanthan gum and (D) sodium polyacrylate and / or sodium alginate is preferably 1.5 to 20, more preferably 1.6 to 16, more preferably 2 to 10. Within this range, dispersibility in the oral cavity is further improved, and it is also suitable for appropriate maintenance of formulation hardness.
  • the dentifrice composition of the present invention can further contain (E) an abrasive.
  • an abrasive calcium phosphate abrasives such as dicalcium phosphate dihydrate or anhydrous, primary calcium phosphate, tertiary calcium phosphate, calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-binding silica
  • Silica-based abrasives such as calcium carbonate-based abrasives such as calcium carbonate, and abrasive particles such as calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, etc.
  • silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, especially silica-based materials such as precipitated silica.
  • Abrasives are preferred.
  • Commercially available products can be used as the silica-based abrasive, such as Zeodent 124 and Zedent 113 manufactured by HUBER, TIXOSIL 73 and TIXOSIL 63 manufactured by Rhodia, Sident 3 and Sident 20 manufactured by Degussa, and manufactured by Taki Chemical Co., Ltd. Zirconosilicate, aluminosilicate and the like.
  • the blending amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the whole composition.
  • the abrasive may be granular, and granules can be blended as an abrasive component.
  • the granule is a particle in which a water-insoluble powder is formed into a granule, and a granulated product using a binder may be used for granulation.
  • water-insoluble powder dicalcium phosphate, tricalcium phosphate, water-insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, bengara, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, zirconosilicate Inorganic powders such as calcium sulfate and mixtures thereof can be mentioned, and silica granules and zeolite granules are particularly suitable.
  • the abrasive the above-described abrasive particles and granules may be used in combination.
  • the dentifrice composition of the present invention is particularly suitable as a toothpaste and can be prepared by a known method.
  • the well-known component normally used for the dentifrice composition can be mix
  • the optional components that can be blended include binders other than the components (B) and (D), surfactants other than the component (A), wetting agents, sweeteners, fragrances, pH adjusters, preservatives, medicinal components, and the like. Is mentioned.
  • Binders include inorganic binders such as thickening silica and aluminum silicate; sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, caraya gum, arabiya gum, locust bean gum, polyvinyl alcohol, carboxyvinyl You may mix
  • the thickening silica silica obtained by a known production method having a liquid absorption amount of 2 to 5 ml / g can be used.
  • the measuring method of the amount of liquid absorption is as follows. Weigh 1.0 g of a sample on a clean glass plate, and mix the sample with a stainless steel spatula using a microburet while dripping 42.5% glycerin little by little. The end point is when the sample becomes one lump and comes off cleanly from the glass plate with a spatula, and the required liquid volume (ml) is the liquid absorption.
  • Specific examples of such a thickening silica include Tokuyama Soda Co., Ltd. Tokusil, PQ Corporation SORBOSIL TC15, Rhodia TIXOSIL 43, HUBER Zeodent 153, DSL Japan Co., Ltd. Commercially available products such as Carplex # 67Q made by the manufacturer can be used.
  • sodium carboxymethylcellulose those having an average substitution degree (DS conversion degree) of carboxymethyl group of 0.5 to 1.5 can be preferably used.
  • Sodium carboxymethylcellulose having a viscosity of 15 to 3,000 mPa ⁇ s (2% aqueous solution, measured with a B-type viscometer at 20 ° C., the same shall apply hereinafter) is preferable.
  • the viscosity is a value measured using a B8H type viscometer (for example, manufactured by Tokyo Keiki Co., Ltd.) and using a No. 1 to 4 rotor according to the viscosity range. For example, when the viscosity is less than 100 mPa ⁇ s, the viscosity after 3 minutes at 50 rpm using the No.
  • the blending amount of these binders is preferably 0 to 10%, preferably 0.5 to 10%, more preferably 1 to 8% of the total composition of the inorganic binder.
  • the organic binder other than the components (B) and (D) is preferably 0 to 3%.
  • Nonionic surfactants include: polyoxyethylene hydrogenated castor oil; polyoxyethylene fatty acid ester; polyglycerin fatty acid ester; sucrose fatty acid ester such as maltose fatty acid ester; sugar alcohol fatty acid such as maltitol fatty acid ester and lactitol fatty acid ester Esters; alkylol amides; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate; fatty acid diethanolamides such as lauric acid mono- or diethanolamide; sorbitan fatty acid esters; polyoxyethylene alkyl ethers; polyoxyethylene polyoxypropylene Copolymer; polyoxyethylene polyoxypropylene fatty acid ester.
  • the nonionic surfactant can be blended in an amount of 10% or less of the entire composition, and may be 0%.
  • amphoteric surfactants include fatty acid amidopropyl betaines such as cocamidopropyl betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine; imidazoline type amphoteric surfactants such as coconut oil fatty acid imidazolium betaine, and fatty acid amidopropyl betaines. Is preferred.
  • the zwitterionic surfactant can be added in an amount of 10% or less of the entire composition, and may be 0%.
  • Wetting agents include sorbit, glycerin, propylene glycol, polyethylene glycol, ethylene glycol, 1,3-butylene glycol, erythritol, xylitol having an average molecular weight of 200 to 6,000 (average molecular weight described in quasi-drug raw material specifications) And polyhydric alcohols such as trimethylglycine and reduced starch saccharified product, and sugar alcohols.
  • the blending amount of these wetting agents is preferably 0.1 to 70% of the entire composition.
  • Sweetening agents include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like.
  • fragrance known fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, ⁇ -terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil , Lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like.
  • Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
  • Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
  • Medicinal ingredients include enzymes such as dextranase, amylase, protease, mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate; sodium chloride, vitamins, allantoins, etc.
  • enzymes such as dextranase, amylase, protease, mutanase
  • anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate
  • sodium chloride vitamins, allantoins, etc.
  • bactericides such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; pyrophosphates, polyphosphates, hexametaphosphate Calcium preventive agents such as zeolite, blood circulation promoters such as vitamin E, amino acids such as alanine, glycine and proline; plant extracts such as rosemary and birch.
  • the compounding quantity of a medicinal ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.
  • inorganic compounds such as titanium mica, titanium oxide, bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, glucomannan; polyvinyl acetate, acrylic resin Synthetic polymers such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.
  • Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method, and used as samples, and evaluated by the methods shown in (1) to (3) below. Furthermore, the composition shown in Table 3 was also evaluated by the method shown in (4) below. The results are shown in the table.
  • ⁇ Evaluation method> No dripping About the degree of dripping (dropping of liquid or foam) from the mouth when a specialized panelist (subjects, 3 people) took 1g sample on toothbrush and brushed for 3 minutes Judgment was made using the following criteria. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria. Rating criteria 4 points: The sample did not sag from the mouth even after 3 minutes passed from the start of brushing. 3 points: The sample slid from the mouth within 2 minutes after 2 minutes after the start of brushing. The sample dropped from the mouth within 2 minutes after 1 minute. 1 point: The sample dropped from the mouth within 1 minute after starting brushing. Evaluation criteria ⁇ : More than 3.5 points ⁇ : Over 2.0 points Less than 3.5 points ⁇ : 2.0 points or less
  • Dispersibility in the oral cavity Special panelists (subjects, 3 persons) take a 1g sample on a toothbrush, and determine the dispersibility of the paste in the oral cavity after starting toothbrushing using the following criteria. did. The average value of the scores of three people was calculated and evaluated according to the following evaluation criteria. Rating criteria 4 points: Dispersibility of the paste was very good 3 points: Dispersibility of the paste was quite good 2 points: Dispersibility of the paste was slightly good 1 point: Dispersibility of the paste was not good Evaluation criteria A: 3. 0 or more ⁇ : 2.5 or more and less than 3.0 ⁇ ⁇ : less than 2.5

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de dentifrice qui comprend (A) 1,4 à 2,5% en masse d'un tensio-actif anionique, (B) 1,4 à 2,5% en masse d'une gomme de xanthane, et (C) 0,1 à 5% en masse d'un hydrogénocarbonate. En outre, ladite composition de dentifrice comprend (D) 0,1 à 1% en masse d'au moins un élément choisi parmi un polyacrylate de sodium et un alginate de sodium. Ainsi, il est possible de fournir une composition de dentifrice qui prévient un égouttement de liquide depuis la bouche lors du brossage des dents, qui confère une sensation rafraîchissante, et qui procure une excellente sensation à l'utilisation.
PCT/JP2018/020807 2017-05-31 2018-05-30 Composition de dentifrice WO2018221609A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020197026231A KR20200011409A (ko) 2017-05-31 2018-05-30 치약제 조성물
CN201880033257.3A CN110650722A (zh) 2017-05-31 2018-05-30 洁齿剂组合物

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Application Number Priority Date Filing Date Title
JP2017107590A JP7347916B2 (ja) 2017-05-31 2017-05-31 歯磨剤組成物
JP2017-107590 2017-05-31

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WO2018221609A1 true WO2018221609A1 (fr) 2018-12-06

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JP (1) JP7347916B2 (fr)
KR (1) KR20200011409A (fr)
CN (1) CN110650722A (fr)
WO (1) WO2018221609A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113710328A (zh) * 2019-04-05 2021-11-26 狮王株式会社 洁齿剂组合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136212A (ja) * 1984-07-26 1986-02-20 Lion Corp 口腔用組成物
JPH111418A (ja) * 1997-06-10 1999-01-06 Lion Corp 歯磨組成物
JP2009137908A (ja) * 2007-12-10 2009-06-25 Lion Corp 歯磨剤組成物
JP2009149540A (ja) * 2007-12-19 2009-07-09 Lion Corp 歯磨組成物

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JPH08333228A (ja) * 1995-06-05 1996-12-17 Lion Corp 歯磨組成物
JPH09132517A (ja) 1995-11-09 1997-05-20 Lion Corp 口腔用組成物
JP2002104945A (ja) 2000-07-25 2002-04-10 Lion Corp 歯磨剤組成物
JP5033283B2 (ja) 2001-04-03 2012-09-26 日本ゼトック株式会社 口腔用組成物
JP3959636B2 (ja) 2002-02-15 2007-08-15 ライオン株式会社 練歯磨組成物
WO2012165134A1 (fr) * 2011-05-27 2012-12-06 ライオン株式会社 Composition orale
CN103998017B (zh) * 2011-12-20 2017-04-12 狮王株式会社 洁齿剂组合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136212A (ja) * 1984-07-26 1986-02-20 Lion Corp 口腔用組成物
JPH111418A (ja) * 1997-06-10 1999-01-06 Lion Corp 歯磨組成物
JP2009137908A (ja) * 2007-12-10 2009-06-25 Lion Corp 歯磨剤組成物
JP2009149540A (ja) * 2007-12-19 2009-07-09 Lion Corp 歯磨組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113710328A (zh) * 2019-04-05 2021-11-26 狮王株式会社 洁齿剂组合物
CN113710328B (zh) * 2019-04-05 2024-01-09 狮王株式会社 洁齿剂组合物

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KR20200011409A (ko) 2020-02-03
JP7347916B2 (ja) 2023-09-20
CN110650722A (zh) 2020-01-03

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