CN110691581B - 洁齿剂组合物 - Google Patents
洁齿剂组合物 Download PDFInfo
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- CN110691581B CN110691581B CN201880036155.7A CN201880036155A CN110691581B CN 110691581 B CN110691581 B CN 110691581B CN 201880036155 A CN201880036155 A CN 201880036155A CN 110691581 B CN110691581 B CN 110691581B
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- feeling
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- dentifrice composition
- sodium
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- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 239000000551 dentifrice Substances 0.000 title claims abstract description 35
- -1 polyoxyethylene Polymers 0.000 claims abstract description 46
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 20
- 239000002738 chelating agent Substances 0.000 claims abstract description 15
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 14
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 12
- 239000004359 castor oil Substances 0.000 claims abstract description 10
- 235000019438 castor oil Nutrition 0.000 claims abstract description 10
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 10
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 9
- 150000005215 alkyl ethers Chemical class 0.000 claims abstract description 8
- FPJRGEOLQICYQZ-UHFFFAOYSA-N n-[4-(cyanomethyl)phenyl]-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(=O)NC1=CC=C(CC#N)C=C1 FPJRGEOLQICYQZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 235000015165 citric acid Nutrition 0.000 claims description 8
- 235000021317 phosphate Nutrition 0.000 claims description 8
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 6
- 239000001630 malic acid Substances 0.000 claims description 6
- 235000011090 malic acid Nutrition 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
- 235000019830 sodium polyphosphate Nutrition 0.000 claims description 5
- 239000004711 α-olefin Substances 0.000 claims description 5
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 4
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 4
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 4
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 2
- 125000004442 acylamino group Chemical group 0.000 claims description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
- 150000003871 sulfonates Chemical class 0.000 claims 1
- 206010006326 Breath odour Diseases 0.000 abstract description 45
- 208000032139 Halitosis Diseases 0.000 abstract description 41
- 210000000214 mouth Anatomy 0.000 abstract description 28
- 235000014113 dietary fatty acids Nutrition 0.000 abstract description 20
- 239000000194 fatty acid Substances 0.000 abstract description 20
- 229930195729 fatty acid Natural products 0.000 abstract description 20
- 238000004140 cleaning Methods 0.000 abstract description 13
- 230000002265 prevention Effects 0.000 abstract description 13
- 230000003405 preventing effect Effects 0.000 description 23
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 16
- 230000000694 effects Effects 0.000 description 14
- 239000000377 silicon dioxide Substances 0.000 description 11
- 239000011230 binding agent Substances 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- 235000002639 sodium chloride Nutrition 0.000 description 9
- 235000017557 sodium bicarbonate Nutrition 0.000 description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 8
- 230000000638 stimulation Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 235000019645 odor Nutrition 0.000 description 6
- 230000035807 sensation Effects 0.000 description 6
- 235000019615 sensations Nutrition 0.000 description 6
- 229920000388 Polyphosphate Polymers 0.000 description 5
- 239000003082 abrasive agent Substances 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 238000005498 polishing Methods 0.000 description 5
- 239000001205 polyphosphate Substances 0.000 description 5
- 235000011176 polyphosphates Nutrition 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 4
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 4
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- 239000005749 Copper compound Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 150000001880 copper compounds Chemical class 0.000 description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229940048084 pyrophosphate Drugs 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 235000015424 sodium Nutrition 0.000 description 3
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- AXCXHFKZHDEKTP-NSCUHMNNSA-N 4-methoxycinnamaldehyde Chemical compound COC1=CC=C(\C=C\C=O)C=C1 AXCXHFKZHDEKTP-NSCUHMNNSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 235000005206 Hibiscus Nutrition 0.000 description 2
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 description 2
- 244000284380 Hibiscus rosa sinensis Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000282320 Panthera leo Species 0.000 description 2
- 240000008474 Pimenta dioica Species 0.000 description 2
- 235000006990 Pimenta dioica Nutrition 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 230000003749 cleanliness Effects 0.000 description 2
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- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
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- 235000003599 food sweetener Nutrition 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229940005740 hexametaphosphate Drugs 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
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- 230000002829 reductive effect Effects 0.000 description 2
- 108700004121 sarkosyl Proteins 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 2
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- 159000000000 sodium salts Chemical class 0.000 description 2
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- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
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Abstract
本发明涉及一种洁齿剂组合物，其含有(A)选自碳酸氢盐(A‑1)和螯合剂(A‑2)中的1种以上、(B)阴离子型表面活性剂、(C)选自聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚和聚甘油脂肪酸酯中的1种以上的非离子型表面活性剂和(D)N‑(4‑氰基甲基苯基)‑2‑异丙基‑5‑甲基环己烷甲酰胺。本发明可以提供赋予优异的口腔内清洁实际感觉和预防口臭实际感觉、使用感也良好、适宜用于预防口臭的洁齿剂组合物。
Description
技术领域
本发明涉及使用感良好的洁齿剂组合物。
背景技术
近年来，由于预防口臭是重要的礼仪之一，因此，对预防口臭的实际感觉优异的口腔用制剂有较高期待。这种倾向特别是在年轻人中特别显著。
迄今为止，已知有：通过杀菌剂对口臭致病菌进行杀菌；通过酶、迷迭香提取物等除臭剂的使用抑制口臭的发生的手段，能够得到一定的预防口臭效果。此外，使用缩合磷酸盐等清洁口腔内的手段在预防口臭方面也有效。
但是，近年来，对臭味敏感的使用者中实际上对其他人没有问题却因口臭烦恼的情况增多。认为这是由于充满自身的口腔内的一点点臭味的感知或口腔内的不快感引起的口臭不安感。
迄今为止的作为以预防口臭为目的的口腔用组合物，在使用于口腔内期间、或刚使用后赋予某种程度的预防口臭感(感觉到口臭被抑制或预防的效果实际感觉)，但是，很难说其预防口臭感充分。
虽然，专利文献1(日本特开2003-231621号公报)中，通过在水溶性铜化合物中并用聚磷酸盐和碳酸氢盐，专利文献2(日本特开平10-212220号公报)中，通过在杀菌剂中并用非离子表面活性剂和/或两性表面活性剂以及碱金属的重碳酸盐和/或碳酸盐，从而改善基于口腔用组合物的口臭防止效果的持续性，但是关于口臭抑制感不清楚。
另一方面，虽然碳酸氢盐的碳酸氢钠具有特有的令人不快的味道，但赋予口腔内清爽感，专利文献3(日本特开平11-49654号公报)中提出，在碳酸氢钠并用月桂基硫酸钠和两性表面活性剂，从而抑制粘膜刺激保持口腔内的清爽感的口腔用组合物。进一步地，在混合碳酸氢钠作为研磨剂的所谓的小苏打洁齿剂中也具有一定的使口腔内清爽的效果，但是，碳酸氢钠带来的口臭抑制感未必可称为充分，而且，根据混合量不同，也有赋予刺激感的情况，有不适于近年来需求渐渐增高的低刺激制剂的情况。
现有技术文献
专利文献
【专利文献1】日本特开2003-231621号公报
【专利文献2】日本特开平10-212220号公报
【专利文献3】日本特开平11-49654号公报
【专利文献4】日本特开2014-125440号公报
【专利文献5】日本特开2015-182983号公报
【专利文献6】日本特开2016-102076号公报
【专利文献7】日本特表2014-507440号公报
【专利文献8】日本特表2012-508741号公报
【专利文献9】日本特表2011-520925号公报
发明内容
发明要解决的课题
本发明鉴于上述情况而完成，目的在于提供赋予口腔内高清洁实际感觉和优异的预防口臭实际感觉、使用感良好、作为预防口臭用适宜的洁齿剂组合物。
解决课题的手段
为了达到上述目的，本发明人深入研究，结果发现，在选自碳酸氢盐和螯合剂中的1种以上中，组合混合阴离子型表面活性剂、特定的非离子型表面活性剂以及特定的N-取代-对-薄荷烷-甲酰胺时，口腔用组合物特别是洁齿剂组合物赋予口腔内高清洁实际感觉和优异的预防口臭实际感觉，使用感良好，可有效地用于预防口臭，从而完成本发明。
即，本发明中，在洁齿剂组合物中分别混合特定量的(A)选自碳酸氢盐(A-1)和螯合剂(A-2)中的1种以上、(B)阴离子型表面活性剂、(C)选自聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚和聚甘油脂肪酸酯中的1种以上的非离子型表面活性剂，且以较少的量混合(D)N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺，从而这些成分特异性地相互作用，由此赋予口腔内清洁实际感觉以及预防口臭实际感觉的作用提高，此外，刺激感也被抑制。因此，根据本发明，可以在适用于口腔内之后抑制刺激感而赋予口腔内高清洁实际感觉和优异的预防口臭实际感觉，由此，能够抑制由充满口腔内的一点点臭味和口腔内的不快感导致的口臭不安感。
另外，本发明的作用机制尚不明确，但是推测对口腔粘膜的作用性、污渍去除作用和冷凉化作用等因素复合性地参与。
本发明中，如下述的实施例中也显示，通过(A)、(B)、(C)和(D)成分的组合，发挥缺少任一种成分时所不能达到的特异性且特别的作用效果。例如下述的比较所示，不混合(A)成分时，即使混合(B)和(C)成分以及(D)成分，口腔内清洁实际感觉和预防口臭实际感觉也差(比较例1)，进一步地，即使增加(B)成分的含量，也不能得到充分的口腔内清洁实际感觉，刺激感也增强(比较例4)。不混合(D)成分时，即使混合(A)成分以及(B)和(C)成分，口腔内清洁实际感觉和预防口臭实际感觉也差(比较例7、9)。此外，不混合(B)或(C)成分，或者(B)或(C)成分的混合量过少时，即使混合(A)和(B)成分，口腔内清洁实际感觉、预防口臭实际感觉也差，或刺激感也增强，本发明的作用效果也差(比较例3～6)。
另外，如专利文献1、2所记载，为了口臭的预防或抑制，即使不使用杀菌剂、水溶性铜化合物，本发明中也可以赋予优异的口腔内清洁实际感觉和预防口臭实际感觉。此外，专利文献4～9(日本特开2014-125440号、日本特开2015-182983号、日本特开2016-102076号公报；日本特表2014-507440号、日本特表2012-508741号、日本特表2011-520925号公报)公开了混合N-取代-对-薄荷烷-甲酰胺的口腔用组合物，它们是作为冷凉化或清凉化剂的N-取代-对-薄荷烷-甲酰胺带来的清凉感、清爽感的改善。与此相对地，本发明为(D)成分带来的、而且通过组合(D)成分以及(A)、(B)和(C)成分带来的口腔内清洁实际感觉和预防口臭实际感觉的提高。
因此，本发明提供下述的洁齿剂组合物。
〔1〕一种洁齿剂组合物，其含有
0.1～10质量％的(A)选自碳酸氢盐(A-1)和螯合剂(A-2)中的1种以上、
1～3质量％的(B)阴离子型表面活性剂、
0.1～1质量％的(C)选自聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚和聚甘油脂肪酸酯中的1种以上的非离子型表面活性剂，和
0.00001～0.01质量％的(D)N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺。
〔2〕根据〔1〕所述的洁齿剂组合物，其中，螯合剂(A-2)选自缩合磷酸盐和果酸。
〔3〕根据〔2〕所述的洁齿剂组合物，其中，缩合磷酸盐选自焦磷酸钠、聚磷酸钠和六偏磷酸钠。
〔4〕根据〔2〕所述的洁齿剂组合物，其中，果酸选自苹果酸、柠檬酸和酒石酸。
〔5〕根据〔1〕～〔4〕中任一项所述的洁齿剂组合物，其中，(A)成分为碳酸氢盐(A-1)和螯合剂(A-2)，(A-1)成分的含量为0.1～5质量％，(A-2)成分的含量为0.1～5质量％，且(A-1)和(A-2)成分的总含量为0.2～10质量％。
〔6〕根据〔1〕～〔5〕中任一项所述的洁齿剂组合物，其中，所述洁齿剂组合物还含有8～70质量％的研磨剂。
发明效果
本发明可以提供，赋予口腔内高清洁实际感觉和优异的预防口臭实际感觉、此外刺激感也被抑制、使用感良好、适宜用于预防口臭的洁齿剂组合物。本发明的洁齿剂组合物也可以期待作为用于消除近年来增加的对臭味敏感的使用者的口臭不安感的预防口臭用制剂的应用。
具体实施方式
以下，进一步地详细说明本发明。本发明的洁齿剂组合物含有(A)选自碳酸氢盐(A-1)和螯合剂(A-2)中的1种以上、(B)阴离子型表面活性剂、(C)选自聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚和聚甘油脂肪酸酯中的1种以上的非离子型表面活性剂和(D)N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺。
(A)成分为碳酸氢盐(A-1)、螯合剂(A-2)，也可以是碳酸氢盐(A-1)或螯合剂(A-2)，从显现效果的角度考虑，也可以使用碳酸氢盐(A-1)和螯合剂(A-2)。
作为碳酸氢盐(A-1)可以使用碳酸氢钠。
碳酸氢盐(A-1)的混合量优选整个组合物的0.1～10％(质量％，以下相同)，更优选0.3～5％。
作为螯合剂(A-2)，可以使用缩合磷酸盐、果酸，特别优选缩合磷酸盐。
作为缩合磷酸盐，可列举例如焦磷酸盐、聚磷酸盐、六偏磷酸盐等，作为盐，可列举钠盐等碱金属盐。其中，从清洁实际感觉和预防口臭感实际感觉的角度考虑，优选焦磷酸盐、聚磷酸盐、六偏磷酸盐，特别优选焦磷酸盐、聚磷酸盐。尤其是，从预防口臭实际感觉的角度考虑，更优选聚磷酸盐聚磷酸钠。
作为果酸，可列举例如苹果酸、柠檬酸、酒石酸等。其中，从预防口臭实际感觉的角度考虑，优选苹果酸、柠檬酸，特别优选柠檬酸。
螯合剂(A-2)的混合量优选整个组合物的0.1～5％，更优选0.5～3％。
(A)成分((A-1)、(A-2)成分)的混合量为整个组合物的0.1～10％，优选0.2～10％，进一步地优选0.2～5％。小于0.1％时，清洁实际感觉和预防口臭实际感觉差。大于10％时，刺激感增强。
进一步地，(A)成分为碳酸氢盐(A-1)和螯合剂(A-2)时，(A-1)成分的混合量优选0.1～5％，(A-2)成分的混合量优选0.1～5％。
作为(B)阴离子型表面活性剂，可列举月桂基硫酸盐、肉豆蔻基硫酸盐等烷基硫酸盐；α-烯烃磺酸盐、氢化椰油脂肪酸单甘油酯单硫酸盐、月桂醇磺基乙酸盐、N-甲基-N-酰基牛磺酸盐等N-酰基牛磺酸盐；月桂酰基肌氨酸盐等酰基肌氨酸盐；N-酰基-L-谷氨酸盐等酰基氨基酸盐。作为盐，可列举钠盐等碱金属盐。其中，从抑制刺激感的角度考虑，优选烷基硫酸盐的月桂基硫酸钠、α-烯烃磺酸盐的α-烯烃磺酸钠、酰基肌氨酸盐的月桂酰基肌氨酸钠，特别优选月桂基硫酸钠。
(B)阴离子型表面活性剂的混合量为整个组合物的1～3％，优选1.4～2.5％，更优选1.4～2.0％。小于1％时，清洁实际感觉和预防口臭实际感觉差。大于3％时，刺激感增强。
(C)成分为选自聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚和聚甘油脂肪酸酯中的1种或2种以上的非离子型表面活性剂。其中，从预防口臭实际感觉和刺激感抑制的角度考虑，优选聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚，特别优选聚氧乙烯氢化蓖麻油。
聚氧乙烯氢化蓖麻油的氧化乙烯的平均加成摩尔数(以下，简称为E.O.)优选为10～60摩尔。
聚氧乙烯烷基醚的E.O.优选为2～25摩尔，烷基的碳原子数优选为12～18。
聚甘油脂肪酸酯的脂肪酸的碳原子数优选为12～18。
(C)成分的混合量为整个组合物的0.1～1％，优选0.3～1％，特别优选0.3～0.8％。小于0.1％时，清洁实际感觉差。大于1％时，预防口臭实际感觉降低，此外，也有清洁实际感觉降低的情况。
另外，本发明中，可以在不妨碍本发明效果的范围内进一步地混合(C)成分以外的非离子型表面活性剂。
作为(C)成分以外的非离子型表面活性剂，可列举聚氧乙烯脂肪酸酯；麦芽糖脂肪酸酯等蔗糖脂肪酸酯；麦芽糖醇脂肪酸酯、乳糖醇脂肪酸酯等糖醇脂肪酸酯；烷醇酰胺；聚氧乙烯脱水山梨糖醇单硬脂酸酯等聚氧乙烯脱水山梨糖醇脂肪酸酯；月桂酸单乙醇酰胺或月桂酸二乙醇酰胺等脂肪酸二乙醇酰胺；脱水山梨糖醇脂肪酸酯；聚氧乙烯聚氧丙烯共聚物；聚氧乙烯聚氧丙烯脂肪酸酯。
混合(C)成分以外的非离子型表面活性剂时，其混合量为整个组合物的3％以下，特别优选1％以下，此外，可以不混合，为0％。
(D)N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺起到提高清洁实际感觉和预防口臭感实际感觉的作用。另外，使用(D)成分以外的N-取代-对-薄荷烷-甲酰胺代替(D)成分时，不能得到本发明的清洁实际感觉和预防口臭感实际感觉，作用效果差。
(D)成分的混合量为整个组合物的0.00001～0.01％，优选0.00005～0.005％。小于0.00001％时，清洁实际感觉和预防口臭感实际感觉差。大于0.01％时，刺激感增强。
另外，本发明中，可以混合公知的香料。例如可列举薄荷脑、茴香脑、香芹酮、丁香酚、柠檬烯、正癸醇、香茅醇、α-松油醇、乙酸香茅酯、桉树脑、芳樟醇、乙基芳樟醇、香草醛、百里酚、留兰香油、薄荷油、鼠尾草油、迷迭香油、桂皮油、多香果油(pimenta oil)、桂叶油、紫苏油、冬青油、丁香油、桉叶油等。在不妨碍本发明效果的范围内这些香料的混合量为通常量。
本发明的洁齿剂组合物可以以膏状、液体等液状等形态制成膏状洁齿剂、液体洁齿剂、液状洁齿剂、润制洁齿剂(tooth wet-powder)等各种剂型，可以用通常的方法制备。此外，除了上述成分以外，通常，在不损害本发明效果的范围内，可以根据需要混合洁齿剂组合物中使用的其他公知成分。作为可以混合的任意成分，可列举研磨剂、粘结剂、润湿剂、阴离子型表面活性剂和非离子型表面活性剂以外的表面活性剂、甜味剂、防腐剂、pH调节剂、药效成分等。
作为研磨剂，可列举二水合磷酸一氢钙或无水磷酸一氢钙、磷酸二氢钙、磷酸三钙、焦磷酸钙等磷酸钙系化合物；沉淀二氧化硅、硅酸铝、硅酸锆、钛结合性二氧化硅等二氧化硅系研磨剂；碳酸钙等碳酸钙系研磨剂；氢氧化钙；氢氧化铝；磷酸三镁；碳酸镁；硫酸钙；膨润土；羟基磷灰石，可以使用它们中的1种或混合2种以上。它们之中，特别优选沉淀二氧化硅、硅酸铝、硅酸锆、钛结合性二氧化硅等以硅酸盐为主成分的二氧化硅系研磨剂、碳酸钙系研磨剂，尤其优选沉淀二氧化硅等二氧化硅系研磨剂。
研磨剂特别是沉淀二氧化硅，优选是粒径为1～40μm、BET比表面积为每1g80～250平方米的研磨粒子。上述粒径是用粒度分布测定装置(日机装株式会社制，麦奇克粒度分布计，分散剂；水)测定的值。
作为这样的二氧化硅系研磨剂，可以使用市售品，可列举例如HUBER公司制造的Zeodent124、Zeodent113；Rhodia公司制造的TIXOSIL 73、TIXOSIL 63；Degussa公司制造的Sident 3、Sident 20；多木化学株式会社制造的硅酸锆、硅酸铝等。
研磨剂的混合量为整个组合物的8～70％，特别优选10～50％。
此外，研磨剂可为颗粒状，作为具有研磨性的成分，可以混合颗粒。作为颗粒，是使水不溶性粉体形成为颗粒状的粒子，也可以是粒状化中使用粘合剂的造粒物。
作为粘结剂，可以混合黄原胶、羧甲基纤维素钠、聚丙烯酸钠、海藻酸钠、聚乙烯吡咯烷酮、卡拉胶、甲基纤维素、羟乙基纤维素钠、黄蓍胶、刺梧桐胶、阿拉伯胶、槐豆胶、聚乙烯醇、羧乙烯基聚合物、卡波姆(carbopol)、硅酸镁铝(Veegum)、海藻酸丙二醇酯等有机粘结剂；增稠性二氧化硅、硅酸铝等无机粘结剂。它们可以使用1种或2种以上。为有机粘结剂的时，这些粘结剂的混合量为整个组合物的0.8～5％，特别优选1～3％，为无机粘结剂的时，这些粘结剂的混合量为整个组合物的0.5～10％，特别优选1～8％。
作为润湿剂，可列举山梨糖醇、木糖醇等糖醇、丙二醇、甘油等多元醇。混合量通常为整个组合物的5～50％，特别优选20～45％。
作为表面活性剂，可以混合两性表面活性剂。具体地，可列举椰油酰胺丙基甜菜碱等脂肪酸酰胺丙基甜菜碱；月桂基二甲基氨基乙酸甜菜碱等烷基甜菜碱；椰油脂肪酸咪唑鎓甜菜碱等咪唑啉型两性表面活性剂。
作为甜味剂，可列举糖精钠、甜菊苷、甜叶菊提取物、对甲氧基肉桂醛、新橙皮苷二氢查尔酮、紫苏葶、甘草甜素、奇异果甜蛋白、天冬酰基苯丙氨酸甲酯等。
作为防腐剂，可列举对羟基苯甲酸酯、苯甲酸或其盐等。
作为pH调节剂，可列举柠檬酸、乳酸等有机酸和其盐类；盐酸、氢氧化钠、氢氧化钾、磷酸氢二钠、磷酸二氢钠等无机化合物。
作为药效成分，可列举氟化钠、单氟磷酸钠等含氟化合物；葡聚糖酶、淀粉酶、蛋白酶、葡聚糖变构水解酶等酶；氨甲环酸、ε-氨基己酸、薁、甘草酸盐、甘草次酸盐等抗炎剂；氯化钠、维生素类、尿囊素类等细胞活化剂；异丙基甲基苯酚、十六烷基氯化吡啶、苯扎氯铵、桧木醇(hinokitiol)、溶菌酶氯化物等杀菌剂；铜叶绿素、葡萄糖酸铜等水溶性铜化合物；沸石等牙结石预防剂；维生素E等血液循环促进剂；丙氨酸、甘氨酸、脯氨酸等氨基酸类。在不妨碍本发明效果的范围内，药效成分的混合量可以取有效量。
进一步地，作为任意成分，可以在不妨碍本发明效果的范围混合云母钛、氧化钛、膨润土等无机化合物；微晶纤维素等纤维素系的有机粉末；琼脂、明胶、淀粉、葡甘露聚糖等天然高分子化合物；聚乙酸乙烯酯、丙烯酸树脂、聚氨酯、聚酯、聚氯乙烯、尼龙粉末、聚乙烯粉末等合成高分子化合物或它们的共聚物；巴西棕榈蜡、松香、米糠蜡、微晶蜡、蜂蜡和石蜡等蜡类；十六烷醇、硬脂醇等高级醇；聚异丁烯、聚丁二烯、硅酮、天然橡胶。
【实施例】
以下，通过实施例和比较例具体地说明本发明，但是本发明并不限于下述的实施例。另外，除非另有说明，否则下述的例中，％均表示质量％。
[实施例、比较例]
按照通常方法制备表1～4所示的组成的洁齿剂组合物。使用得到的洁齿剂组合物作为样品，按照下述方法进行评价。结果一并记于表中。
<评价方法>
由4名受试者兼评价人员评价洁齿剂组合物的使用感。将1g作为样品的洁齿剂组合物置于牙刷(CLINICA ADVANTAGE牙刷，4列紧凑常规款，狮王株式会社制)，刷牙3分钟。
分别按照下述所示的评分标准判定漱口后(刷牙后用水漱口腔内之后)的口腔内清洁实际感觉、预防口臭实际感觉、刷牙中的刺激感。求得4人的分数的平均值，按照下述的评价标准评价。
另外，此处，口腔内清洁实际感觉是指，感觉口腔内被清洁变干净的感觉。预防口臭实际感觉是指，感觉不到口腔内充满的一点点臭味、口腔内不快感。
(1)漱口后的口腔内清洁实际感觉评分标准
1：未感觉到
2：吃不准有否感觉到
3：稍微感觉到
4：感觉到
5：感觉强烈
评价标准
◎：4人的平均分在4分以上
○：4人的平均分在3分以上且小于4分
△：4人的平均分在2分以上且小于3分
×：4人的平均分小于2分
(2)预防口臭实际感觉
评分标准
1：感觉不到
2：说不准是否感觉到
3：稍微感觉到
4：感觉到
5：感觉强烈
评价标准
◎：4人的平均分在4分以上
○：4人的平均分在3分以上且小于4分
△：4人的平均分在2分以上且小于3分
×：4人的平均分小于2分
(3)刷牙中的刺激感
评分标准
1：感觉到强烈的刺激
2：感觉到刺激
3：感觉到稍有刺激但为没有问题的水平
4：几乎感觉不到刺激
5：感觉不到刺激
评价标准
◎：4人的平均分在4分以上
○：4人的平均分在3分以上且小于4分
△：4人的平均分在2分以上且小于3分
×：4人的平均分小于2分
使用原料的详细情况如下述所示。
(A)((A-1))
碳酸氢钠：重碳酸钠(旭硝子株式会社制)
(A)((A-2))
聚磷酸钠：聚磷酸钠(太平化学工业株式会社制)
焦磷酸钠：焦磷酸钠(太平化学工业株式会社制)
六偏磷酸钠：六偏磷酸钠(太平化学产业株式会社制)
苹果酸：苹果酸(扶桑化学工业株式会社制)
柠檬酸：柠檬酸(扶桑化学工业株式会社制)
(B)
月桂基硫酸钠：Texapon(BASF公司制)
α-烯烃磺酸钠：
K LIPOLAN PJ-400CJ(狮王特殊化学株式会社制)
月桂酰基肌氨酸钠：SOYPON SLP(川研精细化学株式会社制)
(C)
聚氧乙烯(20)氢化蓖麻油：
NIKKOL HCO-20(日光化学株式会社制，氧化乙烯的平均加成摩尔数20)
聚氧乙烯(5)硬脂基醚：
EMALEX605(日本Emulsion株式会社制，的平均加成摩尔数5)
(D)
N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺：Ever Cool180(奇华顿日本株式会社(株)制)
【表1】
【表2】
【表3】
【表4】
Claims (5)
1.一种洁齿剂组合物，其含有
0.1～10质量％的(A)选自碳酸氢盐(A-1)和螯合剂(A-2)中的1种以上、
1～3质量％的(B)选自烷基硫酸盐、α-烯烃磺酸盐和酰基氨基酸盐的阴离子型表面活性剂、
0.1～1质量％的(C)选自聚氧乙烯氢化蓖麻油和聚氧乙烯烷基醚中的1种以上的非离子型表面活性剂，和
0.00001～0.01质量％的(D)N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺，
螯合剂(A-2)选自缩合磷酸盐和果酸。
2.根据权利要求1所述的洁齿剂组合物，其中，缩合磷酸盐选自焦磷酸钠、聚磷酸钠和六偏磷酸钠。
3.根据权利要求1所述的洁齿剂组合物，其中，果酸选自苹果酸、柠檬酸和酒石酸。
4.根据权利要求1～3中任一项所述的洁齿剂组合物，其中，(A)成分为碳酸氢盐(A-1)和螯合剂(A-2)，(A-1)成分的含量为0.1～5质量％，(A-2)成分的含量为0.1～5质量％，且(A-1)和(A-2)成分的总含量为0.2～10质量％。
5.根据权利要求1～3中任一项所述的洁齿剂组合物，其中，所述洁齿剂组合物还含有8～70质量％的研磨剂。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017107698 | 2017-05-31 | ||
| JP2017-107698 | 2017-05-31 | ||
| PCT/JP2018/020827 WO2018221617A1 (ja) | 2017-05-31 | 2018-05-30 | 歯磨剤組成物 |
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| Publication Number | Publication Date |
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| JPH09132517A (ja) * | 1995-11-09 | 1997-05-20 | Lion Corp | 口腔用組成物 |
| US5804165A (en) * | 1996-07-24 | 1998-09-08 | Arnold; Michael J. | Antiplaque oral composition |
| JP2000026257A (ja) * | 1998-07-08 | 2000-01-25 | Kao Corp | 口腔用組成物 |
| JP2002104945A (ja) * | 2000-07-25 | 2002-04-10 | Lion Corp | 歯磨剤組成物 |
| JP2003231621A (ja) * | 2002-02-06 | 2003-08-19 | Lion Corp | 口臭予防用口腔用組成物 |
| JP2004018431A (ja) * | 2002-06-14 | 2004-01-22 | Kiyomitsu Kawasaki | 口腔用香料組成物および該香料組成物を含有する口腔組成物 |
| US7803353B2 (en) * | 2006-03-29 | 2010-09-28 | The Procter & Gamble Company | Oral care compositions having improved consumer aesthetics and taste |
| JP5228380B2 (ja) * | 2007-06-18 | 2013-07-03 | ライオン株式会社 | 歯磨剤組成物 |
| CN102123982B (zh) * | 2008-08-15 | 2014-08-06 | 宝洁公司 | 在消费品中可用作感觉剂的环己烷衍生物的合成 |
| ES2626230T3 (es) * | 2008-11-20 | 2017-07-24 | The Procter & Gamble Company | Composiciones para la higiene personal que proporcionan una sensación refrescante mejorada |
| JP5526619B2 (ja) * | 2009-06-25 | 2014-06-18 | ライオン株式会社 | 練歯磨剤組成物 |
| JP2014125440A (ja) * | 2012-12-26 | 2014-07-07 | Lion Corp | 口腔用組成物 |
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| JP2016102076A (ja) * | 2014-11-27 | 2016-06-02 | ライオン株式会社 | 口腔用組成物 |
| JP2016121089A (ja) * | 2014-12-25 | 2016-07-07 | ライオン株式会社 | 口腔用組成物 |
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| 裘炳毅等.薄荷醇.《现代化妆品科学与技术 下》.中国轻工业出版社,2016,第1174页. * |
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| CN110691581A (zh) | 2020-01-14 |
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