JP2018203640A - 歯磨剤組成物 - Google Patents
歯磨剤組成物 Download PDFInfo
- Publication number
- JP2018203640A JP2018203640A JP2017107590A JP2017107590A JP2018203640A JP 2018203640 A JP2018203640 A JP 2018203640A JP 2017107590 A JP2017107590 A JP 2017107590A JP 2017107590 A JP2017107590 A JP 2017107590A JP 2018203640 A JP2018203640 A JP 2018203640A
- Authority
- JP
- Japan
- Prior art keywords
- dentifrice composition
- mass
- sodium
- dripping
- feeling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 60
- 239000000551 dentifrice Substances 0.000 title claims abstract description 36
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 17
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 15
- 239000000230 xanthan gum Substances 0.000 claims abstract description 15
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 15
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 15
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 14
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 9
- 239000000661 sodium alginate Substances 0.000 claims abstract description 9
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 9
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 8
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 6
- 125000000542 sulfonic acid group Chemical group 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000005498 polishing Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 36
- 210000000214 mouth Anatomy 0.000 description 24
- -1 and the like Substances 0.000 description 21
- 239000000377 silicon dioxide Substances 0.000 description 17
- 235000014113 dietary fatty acids Nutrition 0.000 description 14
- 239000000194 fatty acid Substances 0.000 description 14
- 229930195729 fatty acid Natural products 0.000 description 14
- 239000011230 binding agent Substances 0.000 description 11
- 230000001680 brushing effect Effects 0.000 description 11
- 238000011156 evaluation Methods 0.000 description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
- 238000013329 compounding Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 7
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 7
- 230000000638 stimulation Effects 0.000 description 7
- 239000003082 abrasive agent Substances 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 230000007794 irritation Effects 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000004711 α-olefin Substances 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
- 150000008051 alkyl sulfates Chemical class 0.000 description 5
- 238000005187 foaming Methods 0.000 description 5
- 239000006072 paste Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 229910000323 aluminium silicate Inorganic materials 0.000 description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 239000006260 foam Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 235000015424 sodium Nutrition 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 230000008719 thickening Effects 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 229910021536 Zeolite Inorganic materials 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 239000002280 amphoteric surfactant Substances 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 3
- 239000000606 toothpaste Substances 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 239000010457 zeolite Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000282320 Panthera leo Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 125000004442 acylamino group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 2
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
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- 235000011187 glycerol Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
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- 229910010272 inorganic material Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
【解決手段】(A)アニオン性界面活性剤 1.4〜2.5質量%、
(B)キサンタンガム 1.4〜2.5質量%、
(C)炭酸水素塩 0.1〜5質量%
を含有することを特徴とする歯磨剤組成物。更に、(D)ポリアクリル酸ナトリウム及び/又はアルギン酸ナトリウムを0.1〜1質量%含有する、前記の歯磨剤組成物。
【選択図】なし
Description
また、本発明では、更に、ポリアクリル酸ナトリウム又はアルギン酸ナトリウムを配合すると、口腔内での製剤の分散性も改善し、使用感がより向上することも知見した。
この場合、歯磨剤組成物の使用感を改善するため、泡立ちを向上させることを目的として(A)アニオン性界面活性剤を比較的多い量で配合すると、泡立ちは向上できても、歯磨きを開始してまもなく口から泡が垂れ出し液垂れしてしまう場合があるが、(B)キサンタンガムを特定量以上で併用して配合することによって、歯磨き時の口からの液垂れを効果的に防止し、長時間に亘って持続的に防ぐこともできた。しかし、この場合、(A)及び(B)成分の併用によって、歯磨き時に口をすすいだ後のサッパリ感が損なわれて使用感が低下してしまうという別の問題が生じた。そこで、更に検討を進めたところ、(C)炭酸水素塩を特定量以下で配合することで、前記のようにサッパリ感低下の問題を生じさせることなく液垂れを防止することができた。なお、炭酸水素塩には使用感改善作用があるものの、(A)成分を特定量以上配合し、かつ炭酸水素塩を多く配合し過ぎると刺激が強くなるが、(A)、(B)及び(C)成分の三者をそれぞれ特定量で組み合わせることによって、意外にも、液垂れの防止及びサッパリ感の付与が両立して使用感が向上し、格別な作用効果を付与できた。
歯磨剤組成物では、粘結剤として曳糸性に影響するおそれがあるキサンタンガムは1質量%に満たない量で使用されることが多いが、本発明では、キサンタンガムを1.4質量%以上使用することで、予想外に上述のような作用効果を奏する。
後述の実施例にも示すように、本発明の(A)、(B)及び(C)成分を配合した歯磨剤組成物は、歯磨き開始後1分、更には2分を超えて経過しても口からの液垂れが抑えられ、液垂れのなさが優れ、また、サッパリ感及び刺激のなさも優れる。これに対して、比較例に示すように(A)、(B)及び(C)成分のいずれかを欠く場合、あるいは三者が配合されていてもいずれかの配合量が不適切な場合は、本発明の作用効果が劣る。
〔1〕
(A)アニオン性界面活性剤 1.4〜2.5質量%、
(B)キサンタンガム 1.4〜2.5質量%、
(C)炭酸水素塩 0.1〜5質量%
を含有することを特徴とする歯磨剤組成物。
〔2〕
(A)成分が、スルホン酸基を含有するアニオン性界面活性剤である〔1〕に記載の歯磨剤組成物。
〔3〕
(C)炭酸水素塩が炭酸水素ナトリウムであり、その含有量が0.1〜3質量%である〔1〕又は〔2〕に記載の歯磨剤組成物。
〔4〕
(A)/(B)が質量比として0.7〜1.7である〔1〕〜〔3〕のいずれかに記載の歯磨剤組成物。
〔5〕
更に、(D)ポリアクリル酸ナトリウム及び/又はアルギン酸ナトリウムを0.1〜1質量%含有する〔1〕〜〔4〕のいずれかに記載の歯磨剤組成物。
〔6〕
(B)/(D)が質量比として1.5〜20である〔5〕に記載の歯磨剤組成物。
〔7〕
更に、(E)研磨剤を8〜70質量%含有する〔1〕〜〔6〕のいずれかに記載の歯磨剤組成物。
アルキル硫酸塩は、アルキル基の炭素数が好ましくは10〜14であり、具体的には、アルキル硫酸塩としてラウリル硫酸ナトリウム、ミリストイル硫酸ナトリウムが挙げられる。
α−オレフィンスルホン酸塩としては、炭素数が14〜16のα−オレフィンスルホン酸のナトリウム、カリウム等のアルカリ金属塩を用いることができ、中でも炭素数14のα−オレフィンスルホン酸塩、特にナトリウム塩(一般名;テトラデセンスルホン酸ナトリウム)が好ましい。これらは口腔用製剤に使用可能な市販品を入手することができ、例えばライオン・スペシャリティ・ケミカルズ(株)製の商品名「KリポランPJ−400CJ」を使用し得る。
(C)炭酸水素塩の配合量は、組成物全体の0.1〜5%であり、好ましくは0.1〜3%、より好ましくは0.3〜2%、更に好ましくは0.3〜1%である。0.1%未満であると、サッパリ感が不足し、5%を超えると、刺激や違和感が強くなり、また、液垂れを十分に防止できなくなることがある。
(D)成分は、ポリアクリル酸ナトリウム、アルギン酸ナトリウムのいずれかであってもよいが、効果発現の点で両者を併用してもよい。
(D)成分の配合量は、組成物全体の0.1〜1%が好ましく、より好ましくは0.3〜1%である。0.1%以上であると、口腔内分散性が十分に向上する。1%を超えると、製剤が固くなり過ぎる場合がある。
研磨剤としては、第2リン酸カルシウム・2水和塩又は無水和物、第1リン酸カルシウム、第3リン酸カルシウム、ピロリン酸カルシウム等のリン酸カルシウム系化合物;沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のシリカ系研磨剤;炭酸カルシウム等の炭酸カルシウム系研磨剤;水酸化カルシウム、水酸化アルミニウム、第3リン酸マグネシウム、炭酸マグネシウム、硫酸カルシウム、ベントナイト、ハイドロキシアパタイトなどの研磨粒子が挙げられ、これらの1種又は2種以上を配合できる。これらの中では、特に沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のケイ酸塩を主成分とするシリカ系研磨剤や炭酸カルシウム系研磨剤、とりわけ沈降性シリカ等のシリカ系研磨剤が好ましい。
シリカ系研磨剤としては、市販品を使用でき、例えば、HUBER社製のZeodent124、Zeodent113、Rhodia社製のTIXOSIL 73、TIXOSIL 63、Degussa社製のSident 3、Sident 20、多木化学(株)製のジルコノシリケート、アルミノシリケートなどが挙げられる。
研磨剤の配合量は、組成物全体の8〜70%、特に10〜50%が好ましい。
水不溶性粉体としては、第二リン酸カルシウム、第三リン酸カルシウム、水不溶性メタリン酸カルシウム、シリカ、水酸化アルミニウム、リン酸マグネシウム、ベンガラ、炭酸カルシウム、ピロリン酸カルシウム、ゼオライト、アルミノ珪酸塩、炭酸マグネシウム、ジルコノシリケート、硫酸カルシウム等の無機粉体やこれらの混合物が挙げられ、特にシリカ顆粒、ゼオライト顆粒が好適である。
研磨剤は、上述の研磨粒子と顆粒を併用してもよい。
試料1.0gを清浄なガラス板上に量り取り、ミクロビュレットを用いて、42.5%グリセリンを少量ずつ滴下しながらステンレス製のへらで液が均一になるように試料を混合する。試料が一つの塊となり、へらでガラス板よりきれいに剥がれるようになったときを終点とし、要した液量(ml)を吸液量とする。
このような増粘性シリカとして具体的には、徳山曹達(株)製のTokusil、PQコーポレーション(株)製のSORBOSIL TC15、Rhodia社製のTIXOSIL 43、HUBER社製のZeodent 153、DSLジャパン(株)製のカープレックス #67Qなどの市販品を使用できる。
カルボキシメチルセルロースナトリウムは、粘度が15〜3,000mPa・s(2%水溶液、20℃におけるB型粘度計による測定値、以下同様。)のものが好適である。
なお、上記粘度は、B8H型粘度計(例えば(株)東京計器製)を用い、粘度域に合わせて1〜4番のロータを用いて測定した値である。例えば、粘度が100mPa・s未満のときは、1番のロータを用いて50rpmで3分後の粘度を、粘度が100mPa・s以上のときは、1〜4番のロータを用いて20rpmで3分後の粘度を測定することができる。
このようなカルボキシメチルセルロースナトリウムとしては、ダイセルファインケム(株)から販売されているCMCダイセル、第一工業製薬(株)製のセロゲン、日本製紙(株)製のサンローズなどの市販品を使用できる。
非イオン性界面活性剤としては、ポリオキシエチレン硬化ヒマシ油;ポリオキシエチレン脂肪酸エステル;ポリグリセリン脂肪酸エステル;マルトース脂肪酸エステル等のショ糖脂肪酸エステル;マルチトール脂肪酸エステル、ラクチトール脂肪酸エステル等の糖アルコール脂肪酸エステル;アルキロールアマイド;ポリオキシエチレンソルビタンモノステアレート等のポリオキシエチレンソルビタン脂肪酸エステル;ラウリル酸モノ又はジエタノールアミド等の脂肪酸ジエタノールアミド;ソルビタン脂肪酸エステル;ポリオキシエチレンアルキルエーテル;ポリオキシエチレンポリオキシプロピレン共重合体;ポリオキシエチレンポリオキシプロピレン脂肪酸エステル等が挙げられる。非イオン性界面活性剤は、組成物全体の10%以下配合することができ、0%であってもよい。
両性界面活性剤としては、コカミドプロピルベタイン等の脂肪酸アミドプロピルベタイン;ラウリルジメチルアミノ酢酸ベタイン等のアルキルベタイン;ヤシ油脂肪酸イミダゾリウムベタイン等のイミダゾリン型両性界面活性剤などが挙げられ、脂肪酸アミドプロピルベタインが好ましい。両性イオン性界面活性剤は、組成物全体の10%以下配合することができ、0%であってもよい。
これら湿潤剤の配合量は、組成物全体の0.1〜70%が好ましい。
防腐剤としては、パラオキシ安息香酸エステル、安息香酸ナトリウム等が挙げられる。
表1〜3に示す組成の練歯磨剤組成物を常法によって調製し、サンプルとして用いて下記の(1)〜(3)に示す方法によって評価した。更に、表3に示す組成については下記の(4)に示す方法によっても評価した。結果を表に併記した。
(1)液垂れのなさ
専門パネラー(被験者、n=3)がハブラシ上に1gのサンプルを取り、3分間歯磨きしたときの口からのサンプルの液垂れ(液や泡の垂れ)の度合いについて、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:歯磨き開始後3分経過しても、サンプルが口から垂れなかった
3点:歯磨き開始後2分を超えて3分以内に、サンプルが口から垂れた
2点:歯磨き開始後1分を超えて2分以内に、サンプルが口から垂れた
1点:歯磨き開始後1分以内に、サンプルが口から垂れた
評価基準
◎:3.5点以上
○:2.0点を超え3.5点未満
×:2.0点以下
専門パネラー(被験者、n=3)がハブラシ上に1gのサンプルを取り、3分間歯磨きし、口内を水ですすいだ後のサッパリ感について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:非常にサッパリ感を感じた
3点:かなりサッパリ感を感じた
2点:ややサッパリ感を感じた
1点:サッパリ感を感じなかった
評価基準
◎:3.0点以上
○:2.0点以上3.0点未満
×:2.0点未満
専門パネラー(被験者、n=3)がハブラシ上に1gのサンプルを取り、3分間歯磨きし、口内を水ですすいだ後の刺激感について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:刺激を感じなかった
3点:ほとんど刺激を感じなかった
2点:やや刺激を感じた
1点:強い刺激を感じた
評価基準
◎:3.5点以上
○:2.5点以上3.5点未満
×:2.5点未満
専門パネラー(n=3)がハブラシ上に1gのサンプルを取り、歯磨きを開始後の口腔内でのペーストの分散性について、下記の評点基準を用いて判定した。3人の評点の平均値を求め、下記の評価基準により評価した。
評点基準
4点:ペーストの分散性が非常によかった
3点:ペーストの分散性がかなりよかった
2点:ペーストの分散性がややよかった
1点:ペーストの分散性がよくなかった
評価基準
◎:3.0点以上
○:2.5点以上3.0点未満
×:2.5点未満
(A)ラウリル硫酸ナトリウム:Texapon(BASF社製)
(A)テトラデセンスルホン酸ナトリウム:
KリポランPJ−400CJ(ライオン・スペシャリティ・ケミカルズ(株)製
)
(B)キサンタンガム:モナートガムDA(CPケルコ社製)
カルボキシメチルセルロースナトリウム(比較品、ダイセル・ファインケム(株)製)
(C)炭酸水素ナトリウム:重炭酸ナトリウム(旭硝子(株)製)
(D)ポリアクリル酸ナトリウム:レオジック260H(東亞合成(株)製)
(D)アルギン酸ナトリウム:キミカアルギン((株)キミカ製)
研磨性シリカ:TIXOSIL 73(Rhodia社製)
増粘性シリカ:カープレックス #67 (DSLジャパン(株)製)
Claims (7)
- (A)アニオン性界面活性剤 1.4〜2.5質量%、
(B)キサンタンガム 1.4〜2.5質量%、
(C)炭酸水素塩 0.1〜5質量%
を含有することを特徴とする歯磨剤組成物。 - (A)成分が、スルホン酸基を含有するアニオン性界面活性剤である請求項1記載の歯磨剤組成物。
- (C)炭酸水素塩が炭酸水素ナトリウムであり、その含有量が0.1〜3質量%である請求項1又は2記載の歯磨剤組成物。
- (A)/(B)が質量比として0.7〜1.7である請求項1〜3のいずれか1項記載の歯磨剤組成物。
- 更に、(D)ポリアクリル酸ナトリウム及び/又はアルギン酸ナトリウムを0.1〜1質量%含有する請求項1〜4のいずれか1項記載の歯磨剤組成物。
- (B)/(D)が質量比として1.5〜20である請求項5記載の歯磨剤組成物。
- 更に、(E)研磨剤を8〜70質量%含有する請求項1〜6のいずれか1項記載の歯磨剤組成物。
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JPH111418A (ja) * | 1997-06-10 | 1999-01-06 | Lion Corp | 歯磨組成物 |
JP2003306416A (ja) * | 2002-02-15 | 2003-10-28 | Lion Corp | 練歯磨組成物 |
JP2009137908A (ja) * | 2007-12-10 | 2009-06-25 | Lion Corp | 歯磨剤組成物 |
JP6052185B2 (ja) * | 2011-12-20 | 2016-12-27 | ライオン株式会社 | 歯磨剤組成物 |
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JPH0742219B2 (ja) * | 1984-07-26 | 1995-05-10 | ライオン株式会社 | 口腔用組成物 |
JPH08333228A (ja) * | 1995-06-05 | 1996-12-17 | Lion Corp | 歯磨組成物 |
JPH09132517A (ja) | 1995-11-09 | 1997-05-20 | Lion Corp | 口腔用組成物 |
JP2002104945A (ja) | 2000-07-25 | 2002-04-10 | Lion Corp | 歯磨剤組成物 |
JP5033283B2 (ja) | 2001-04-03 | 2012-09-26 | 日本ゼトック株式会社 | 口腔用組成物 |
JP2009149540A (ja) * | 2007-12-19 | 2009-07-09 | Lion Corp | 歯磨組成物 |
CN103582475B (zh) * | 2011-05-27 | 2016-08-17 | 狮王株式会社 | 口腔用组合物 |
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JPH111418A (ja) * | 1997-06-10 | 1999-01-06 | Lion Corp | 歯磨組成物 |
JP2003306416A (ja) * | 2002-02-15 | 2003-10-28 | Lion Corp | 練歯磨組成物 |
JP2009137908A (ja) * | 2007-12-10 | 2009-06-25 | Lion Corp | 歯磨剤組成物 |
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WO2020203409A1 (ja) * | 2019-04-05 | 2020-10-08 | ライオン株式会社 | 歯磨剤組成物 |
CN113710328A (zh) * | 2019-04-05 | 2021-11-26 | 狮王株式会社 | 洁齿剂组合物 |
CN113710328B (zh) * | 2019-04-05 | 2024-01-09 | 狮王株式会社 | 洁齿剂组合物 |
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CN110650722A (zh) | 2020-01-03 |
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