WO2018221621A1 - Composition for use in oral cavity - Google Patents
Composition for use in oral cavity Download PDFInfo
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- WO2018221621A1 WO2018221621A1 PCT/JP2018/020844 JP2018020844W WO2018221621A1 WO 2018221621 A1 WO2018221621 A1 WO 2018221621A1 JP 2018020844 W JP2018020844 W JP 2018020844W WO 2018221621 A1 WO2018221621 A1 WO 2018221621A1
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- composition
- extract
- oral cavity
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- oral
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the present invention relates to a composition for oral cavity which has an excellent effect of improving the stickiness in the oral cavity, which also causes bad breath, and has an excellent refreshing feeling imparting effect, which is suitable for suppressing bad breath.
- compositions have been proposed.
- plant extracts such as Lamiaceae and Citrus are known as bad breath suppressing ingredients
- oral compositions containing plant extracts as active ingredients for preventing bad breath are proposed in addition to these.
- Patent Documents 1 to 3 Japanese Patent Laid-Open No. 2005-289918, Japanese Patent No. 5776364, Japanese Patent Laid-Open No. 2016-112634.
- the composition for oral cavity containing these plant extracts is effective for reducing bad breath-causing components such as volatile sulfur, methyl mercaptan and the like, and has an effect of preventing bad breath as breath (interpersonal).
- JP 2005-289918 A Japanese Patent No. 5776364 JP 2016-112634 A JP 2014-125440 A Japanese Patent Laying-Open No. 2015-182983 JP 2016-102076 A Special table 2014-507440 gazette Special table 2012-508741 gazette Special table 2011-520925 JP 2013-112634 A
- the conventional composition for oral cavity aimed at suppressing bad breath cannot provide a sufficient effect that can eliminate the above-mentioned bad breath anxiety, and improvement has been desired.
- This invention is made
- the present inventors have improved the discomfort such as stickiness in the oral cavity, which is considered to be the main cause of bad breath anxiety, and a feeling of cleanliness. Considering that it is effective to enhance the feeling, further studies were made focusing on these points.
- a specific component is selected from the plant extract and the cooling sensation agent, and both components are used in a specific amount and in a specific ratio, the stickiness in the oral cavity is improved and persists over time. It has been found that an excellent effect that gives a refreshing feeling can be obtained. And when the combination system of both components is blended in the composition for oral cavity, the effect of improving the sticky feeling in the oral cavity is excellent, and the above-mentioned sustained and excellent refreshing effect is exerted.
- the single use of the component (A) or the component (B) has almost no effect on improving the stickiness feeling in the oral cavity and the effect of imparting a refreshing feeling (Comparative Example 1). ⁇ 15). Therefore, from this result, it was not considered that the combined effect was improved by using both in combination, but as is clear from the examples described later, in the present invention, the components (A) and (B) When combined, both components are in a specific range and the mass ratio of (A) / (B) is in a specific range, both components act synergistically, suppressing oral irritation and improving the sticky feeling Both the refreshing effect was enhanced and the effect was remarkable.
- Such operational effects of the present invention are specific to the combination of the components (A) and (B), and instead of the component (B), menthol, peppermint oil or Monomenthyl succinate is inferior when used in combination with component (A) (Comparative Examples 16 to 18), and N-substituted-p-menthane-carboxamide other than component (B) may be used in combination with component (A). inferior.
- Patent Documents 4 to 9 JP 2014-125440, JP 2015-182983, JP 2016-102076, JP 2014-507440, JP 2012-508741, JP 2011-11 No.
- Patent Document 10 Japanese Patent Laid-Open No. 2013-112634
- An oral composition containing a mixture of p-menthane-3,8-diol isomers is disclosed.
- the present invention improves the sticky feeling in the oral cavity and imparts a refreshing feeling by the combined use of the components (A) and (B), and its technical idea cannot be predicted from Patent Documents 4 to 10.
- the present invention provides the following oral composition.
- An oral composition containing 0.00001 to 0.01% by mass of one or more selected from (B-2), wherein (A) / (B) is 0.02 to 100 as a mass ratio.
- the plant extract is rosemary, oxon, carrot, sage, licorice, sugar beet, salmon, peanut, olive, tea, yellowfin, black mushroom, salamander, thyme, birch, peonies, flamingo, asenyaku, turmeric, clove, stevia , Mucloj, Marjoram, Melissa, Perilla, Laurel, Eucalyptus, Cola, Luo Hanhua, Camellia, Clove, Allspice, Suou, Shikon, Diou, Forsythia, Chimpi, Keihi, Oregano, Basil, Naginata Koju, Buttonpi and Seitakamiirobaran
- the composition for oral cavity according to [1] which is an extract of one or more kinds of plants.
- the present invention it is possible to provide an oral composition having an excellent effect of improving the stickiness in the oral cavity that also causes bad breath, an excellent refreshing effect, and good usability.
- the composition for oral cavity of the present invention has a high feeling of bad breath suppression and can be suitably used for the suppression of bad breath.
- composition for oral cavity of the present invention comprises (A) a plant extract, (B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N- (2- ( One or more selected from 2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-2) is contained in a specific amount and a specific ratio.
- a plant extract is an extract of a plant, and when used in combination with the component (B), it reduces the stickiness in the oral cavity.
- the plant that is the raw material of the extract is rosemary, hornon, carrot, sage, licorice, sugar beet, persimmon (especially persimmon tannin), jujube, olive (particularly olive leaf), tea, yellowfin (particularly bark) (Owaku), Kuromoji, Salamander, Thyme, Birch, Peonies, Vultures, Asenyaku, Turmeric, Clove, Stevia, Mukuroji, Marjoram, Melissa, Perilla, Laurel, Eucalyptus, Cola, Arachon, Camellia, Clove, Allspice, Suo, Shikon , Daio, Forsythia, Chinpi, Keihi, Oregano, Basil, Naginata Koju, Buttonpi, Seikamirobaran and the like.
- rosemary, oxon, carrot, sage, licorice, sugar beet, salmon, jujube, olive, tea, yellowfin, black moji, salamander are preferred, more preferably rosemary, oxon, carrot, sage, licorice, toki, Salmon, jujube, olive, tea, yellowfin, and more preferred are rosemary, orange, carrot, sage, and liquorice.
- a method for extracting a plant extract a known method can be adopted, and it can be performed under normal extraction conditions. Specifically, a plant extract is obtained by extracting a raw material plant, particularly a powder obtained by pulverizing leaves and stems, using a polar solvent, a nonpolar solvent, or a mixed solvent of a polar solvent and a nonpolar solvent. Obtainable.
- the extraction solvent examples include polar solvents such as water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol, butylene glycol, and glycerin, or n-hexane, petroleum ether, ligroin, and cyclohexane.
- Non-polar solvents such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene and benzene, or a mixed solvent thereof.
- Preferred extraction solvents are water, lower monohydric alcohols having 1 to 5 carbon atoms (particularly methanol, ethanol, propanol, isopropanol, etc.), glycols (particularly propylene glycol, butylene glycol, etc.), or a mixed solvent thereof.
- the mixed solvent preferably has a mixing ratio of water and lower monohydric alcohol or glycol of 10:90 to 90:10 (mass ratio).
- the extraction solvent may be water alone.
- the plant extract extracted using the said solvent by using an extraction residue as a raw material can also be used.
- a commercial item can also be used for such (A) plant extract. Specifically, commercially available products such as Maruzen Pharmaceutical Co., Ltd. and Yamada Yakuken Co., Ltd. can be used.
- the blending amount of the plant extract (A) is 0.00001 to 0.05 (mass%, the same applies hereinafter) of the whole composition as a pure extract excluding the extraction solvent, preferably 0.0001 to 0.005% More preferably, it is 0.0002 to 0.005%. If the blending amount is less than 0.00001%, the effect of improving the sticky feeling is inferior. If it exceeds 0.05%, the stimulation is too strong.
- Component (B) is composed of N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5 It is selected from methylcyclohexanecarboxamide (B-2), preferably N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1).
- the component (B-1) or the component (B-2) may be used, and the components (B-1) and (B-2) are used in terms of the effect. Also good.
- the blending amount of component (B) is 0.00001 to 0.01%, preferably 0.00003 to 0.005% of the entire composition. If it is less than 0.00001%, the effect of improving the sticky feeling and the effect of imparting a refreshing feeling are inferior. If it exceeds 0.01%, the irritation may be too strong and the aftertaste may deteriorate.
- the blending amounts of the component (B-1) and the component (B-2) can be set within the range of the blending amount of the component (B).
- (A) / (B) indicating the blending ratio of the component (A) and the component (B) is 0.02 to 100, preferably 0.05 to 20, more preferably, as a mass ratio. 0.2-5.
- both the effect of improving stickiness and the effect of imparting a refreshing feeling are excellent, and the stimulation is satisfactorily suppressed. If it is less than 0.02, the effect of imparting a refreshing feeling will not be sufficiently maintained, and the stimulation will also be strong. If it exceeds 100, the stimulation becomes stronger.
- the present invention it is preferable to further blend one or more selected from (C) menthyl monosuccinate, N- ⁇ (ethoxycarbonyl) methyl ⁇ -p-menthane-3-carboxamide and menthyl lactate.
- the component (C) is preferably menthyl monosuccinate and N- ⁇ (ethoxycarbonyl) methyl ⁇ -p-menthane-3-carboxamide, more preferably menthyl monosuccinate.
- the blending amount of the component (C) is preferably 0.0001 to 0.01%, more preferably 0.0003 to 0.005% of the entire composition. Within this range, the effect of improving the stickiness is further improved. If it exceeds 0.01%, the irritation may become strong and the aftertaste may deteriorate.
- the composition for oral cavity of the present invention is prepared in the form of solid, liquid, liquid, paste, gel, etc., and is used for toothpastes such as toothpastes, liquid dentifrices, liquid dentifrices, moisturized dentifrices, mouthwashes, and refreshments in the mouth. It is possible to use various dosage forms such as an agent, but in particular, a dentifrice or a mouthwash, especially a dentifrice is suitable, and a toothpaste containing an abrasive is good.
- the manufacturing method can employ a conventional method according to the dosage form.
- an appropriate well-known component can be mix
- examples thereof include abrasives, binders, wetting agents, surfactants, sweeteners, preservatives, pH adjusters, fragrances, and medicinal ingredients.
- examples include a wetting agent, a surfactant, a sweetener, an antiseptic, a pH adjuster, a fragrance, and a medicinal component.
- abrasives examples include calcium phosphate compounds such as dicalcium phosphate dihydrate or anhydrous, primary calcium phosphate, tertiary calcium phosphate, and calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, etc.
- Silica-based abrasives; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, and one or two of these More than seeds can be blended.
- silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, especially silica-based materials such as precipitated silica. Abrasives are preferred.
- the abrasive is preferably abrasive particles having a particle size of 1 to 40 ⁇ m, and the BET specific surface area is preferably 80 to 250 square meters per gram.
- the particle size is a value measured by a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium: water).
- a particle size distribution measuring device manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium: water.
- silica-based abrasive commercially available products can be used.
- the blending amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the whole composition.
- the abrasive may be granular, and granules can be blended as an abrasive component.
- the granule is a particle obtained by forming a water-insoluble powder into a granule, and may be a granule obtained by crushing silica gel or a granulated product using a binder for granulation.
- the above-mentioned abrasive particles having a particle diameter of 1 to 40 ⁇ m and the above-mentioned granules may be used in combination.
- binder As binder, xanthan gum, sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, caraya gum, arabiya gum, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbopol Organic binders such as bee gum and propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate can be blended. These can be used alone or in combination of two or more.
- the blending amount of the binder is preferably 0.8 to 5%, particularly 1 to 3%, and in the case of an inorganic binder, 0.5 to 10% of the whole composition. %, Particularly 1 to 8% is preferred.
- wetting agent examples include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as propylene glycol and glycerin.
- the blending amount is usually 5 to 50%, particularly 20 to 45% of the whole composition.
- the surfactant examples include an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant.
- an anionic surfactant is preferable.
- Anionic surfactants include alkyl sulfates, ⁇ -olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-acyl taurine salts such as N-methyl-N-acyl taurate, Examples include acyl amino acid salts such as acyl sarcosine salt and N-acyl-L-glutamate. These can be used alone or in combination of two or more.
- anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of foaming and foam quality, and alkyl sulfates and ⁇ -olefin sulfonates are more preferable.
- the salt include sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.
- the alkyl sulfate the alkyl group preferably has 12 to 14 carbon atoms. Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
- alkali metal salts such as sodium and potassium of ⁇ -olefin sulfonate having 14 to 16 carbon atoms can be used, and among them, ⁇ -olefin sulfonate having 14 carbon atoms, particularly sodium. Salts (generic name; sodium tetradecene sulfonate) are preferred.
- the amount of the surfactant, particularly an anionic surfactant is preferably 0.6 to 2.5%, more preferably 1 to 2.5% of the whole composition. In the case of a mouthwash, 0 to 1.0%, particularly 0 to 0.3% of the whole composition is preferable.
- sweetener examples include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like.
- preservative examples include paraoxybenzoic acid ester and sodium benzoate.
- pH adjuster examples include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
- fragrance known oral fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, ⁇ -terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, Peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like.
- Medicinal ingredients include enzymes such as dextranase, amylase, protease, mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate; sodium chloride, vitamins, allantoins, etc.
- enzymes such as dextranase, amylase, protease, mutanase
- anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate
- sodium chloride vitamins, allantoins, etc.
- Cell activators such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; calculus prophylaxis; blood circulation promoters such as vitamin E Amino acids such as alanine, glycine and proline can be blended.
- the compounding quantity of a medicinal ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.
- inorganic compounds such as titanium mica, titanium oxide, bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, glucomannan; polyvinyl acetate, acrylic resin Synthetic polymers such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.
- the solvent purified water is generally used.
- a lower monohydric alcohol having 1 to 3 carbon atoms such as ethanol may be blended. The amount of the lower monohydric alcohol is preferably 0 to 10% of the entire composition.
- Dentifrice compositions (toothpaste) or mouthwashes having the compositions shown in Tables 1 to 6 were prepared by conventional methods and stored in ordinary oral preparation containers (toothpaste: laminate tube, mouthwash: bottle). . These were used as samples and evaluated by the methods shown below. The results are shown in Tables 1-6.
- the numerical value of the blending amount of the component (A) in the table is the pure extract amount excluding the extraction solvent.
- B1 N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide >> Product name: Ebacool G-180, manufacturer: Givadan Japan Co., Ltd.
- B2 N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide >> Product name: Evercool G-190, Manufacturer: Givaudan Japan
- a prescription example is shown below.
- the raw materials used are the same as described above.
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Abstract
A composition for use in the oral cavity that contains (A) 0.00001-0.05 mass% of a botanical extract as a pure extract and (B) 0.00001-0.01 mass% of one or more selected from N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexane carboxamide (B-1) and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexane carboxamide (B-2), and has (A)/(B) of 0.02-100 by mass ratio. The above composition for use in the oral cavity that also contains (C) 0.0001-0.01 mass% of one or more selected from menthyl monosuccinate, N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide, and menthyl lactate. The present invention makes it possible to provide a composition for use in the oral cavity that has an excellent ameliorating effect on a feeling of stickiness in the oral cavity and an excellent clean feeling-imparting effect and is suitable for suppressing halitosis.
Description
本発明は、口臭の原因ともなる口腔内のねばつき感の改善効果が優れ、かつ優れたすっきり感付与効果を有し、口臭抑制用として好適な口腔用組成物に関する。
The present invention relates to a composition for oral cavity which has an excellent effect of improving the stickiness in the oral cavity, which also causes bad breath, and has an excellent refreshing feeling imparting effect, which is suitable for suppressing bad breath.
従来、口臭抑制には、殺菌剤による口臭原因菌の殺菌や、消臭剤、口臭原因物質の発生抑制剤等の有効成分の使用が有効であることが知られており、これらを配合した口腔用組成物が提案されている。例えば、シソ科やミカン科などの植物抽出エキスは、口臭抑制成分として知られており、これら以外にも植物のエキスを口臭防止のための有効成分として配合した口腔用組成物が提案されている（特許文献１～３：特開２００５－２８９９１８号公報、特許第５７７６３６４号公報、特開２０１６－１１２６３４号公報）。これら植物抽出エキスを配合した口腔用組成物は、口臭の原因成分、例えば揮発性硫黄、メチルメルカプタン等の減少に有効であり、呼気（対人）としての口臭防止効果を有する。
Conventionally, for the suppression of bad breath, it has been known that sterilization of bad breath-causing bacteria with a bactericide and the use of active ingredients such as deodorizers, generation inhibitors of bad breath-causing substances, etc. are known to be effective. Compositions have been proposed. For example, plant extracts such as Lamiaceae and Citrus are known as bad breath suppressing ingredients, and oral compositions containing plant extracts as active ingredients for preventing bad breath are proposed in addition to these. (Patent Documents 1 to 3: Japanese Patent Laid-Open No. 2005-289918, Japanese Patent No. 5776364, Japanese Patent Laid-Open No. 2016-112634). The composition for oral cavity containing these plant extracts is effective for reducing bad breath-causing components such as volatile sulfur, methyl mercaptan and the like, and has an effect of preventing bad breath as breath (interpersonal).
しかし、近年、実際には他人に検知されるような口臭（呼気口臭）がないにもかかわらず、口腔内に対する不快感によって口臭があるように感じて、対人への口臭を発症しているかもしれないという口臭不安を抱くケースが増加している。このため、このような口臭不安をも解消できれば、口臭が抑制されたという満足な効果感が得られると考えられる。
However, in recent years, even though there is actually no bad breath (exhaled breath) that can be detected by other people, it may cause bad breath due to discomfort in the oral cavity and may cause bad breath to others. There are an increasing number of cases of bad breath insecurity. For this reason, if such bad breath anxiety can be eliminated, it is considered that a satisfactory effect that bad breath is suppressed can be obtained.
しかしながら、従来の口臭抑制を目的とする口腔用組成物では、上述したような口臭不安をも解消し得るような十分な効果感を与えることができず、改善が望まれていた。
However, the conventional composition for oral cavity aimed at suppressing bad breath cannot provide a sufficient effect that can eliminate the above-mentioned bad breath anxiety, and improvement has been desired.
本発明は、上記事情に鑑みなされたもので、口腔内のねばつき感の改善効果が優れ、かつ優れたすっきり感付与効果を有する口腔用組成物を提供することを目的とする。
This invention is made | formed in view of the said situation, and it aims at providing the composition for oral cavity which is excellent in the improvement effect of the stickiness in an oral cavity, and has the outstanding refreshing effect.
本発明者らは、上記目的を達成するためには、特に口臭不安感の主な原因と考えられる口腔内のねばつき感や、すっきり感の少なさといった不快感を改善して口臭抑制の効果感を高めることが有効であると考え、これらの点に着目して更に検討を進めた。その結果、植物の抽出エキスと、冷感剤の中でも特定の成分を選択し、両成分をそれぞれ特定量かつ特定割合で併用すると、口腔内のねばつき感を改善し、かつ経時でも持続する高いすっきり感を与える優れた作用効果が得られることを見出した。そして、両成分の併用系を口腔用組成物に配合すると、口腔内のねばつき感の改善効果が優れる上に、上記のような持続的かつ優れたすっきり感付与効果を発揮し、また、口腔内刺激が抑えられ良好な使用感を与えることができ、これにより、口臭抑制の効果感も高まり、対人的な口臭の抑制のみならず口臭不安感をも解消可能であることを知見し、本発明をなすに至った。
即ち、本発明では、（Ａ）植物エキスをエキス純分として０．００００１～０．０５質量％と、（Ｂ）Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）及びＮ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－２）から選ばれる１種以上を０．００００１～０．０１質量％とを含有し、（Ａ）／（Ｂ）が質量比として０．０２～１００であることによって、口腔内のねばつき感の改善効果が優れ、かつ優れたすっきり感付与効果を有し、使用感も良い口腔用組成物を提供できる。 In order to achieve the above-mentioned object, the present inventors have improved the discomfort such as stickiness in the oral cavity, which is considered to be the main cause of bad breath anxiety, and a feeling of cleanliness. Considering that it is effective to enhance the feeling, further studies were made focusing on these points. As a result, when a specific component is selected from the plant extract and the cooling sensation agent, and both components are used in a specific amount and in a specific ratio, the stickiness in the oral cavity is improved and persists over time. It has been found that an excellent effect that gives a refreshing feeling can be obtained. And when the combination system of both components is blended in the composition for oral cavity, the effect of improving the sticky feeling in the oral cavity is excellent, and the above-mentioned sustained and excellent refreshing effect is exerted. It has been found that the internal irritation can be suppressed and a good feeling of use can be given, which also increases the effectiveness of halitosis suppression, and it is possible not only to suppress interpersonal halitosis but also to eliminate anxiety of halitosis. Invented the invention.
That is, in the present invention, (A) 0.00001 to 0.05% by mass of a plant extract as a pure extract and (B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide ( 0.00001 to 0.01% by mass of one or more selected from B-1) and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-2) When (A) / (B) is contained in a mass ratio of 0.02 to 100, it has an excellent effect of improving the stickiness in the oral cavity, and has an excellent refreshing effect and a feeling of use. A good oral composition can be provided.
即ち、本発明では、（Ａ）植物エキスをエキス純分として０．００００１～０．０５質量％と、（Ｂ）Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）及びＮ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－２）から選ばれる１種以上を０．００００１～０．０１質量％とを含有し、（Ａ）／（Ｂ）が質量比として０．０２～１００であることによって、口腔内のねばつき感の改善効果が優れ、かつ優れたすっきり感付与効果を有し、使用感も良い口腔用組成物を提供できる。 In order to achieve the above-mentioned object, the present inventors have improved the discomfort such as stickiness in the oral cavity, which is considered to be the main cause of bad breath anxiety, and a feeling of cleanliness. Considering that it is effective to enhance the feeling, further studies were made focusing on these points. As a result, when a specific component is selected from the plant extract and the cooling sensation agent, and both components are used in a specific amount and in a specific ratio, the stickiness in the oral cavity is improved and persists over time. It has been found that an excellent effect that gives a refreshing feeling can be obtained. And when the combination system of both components is blended in the composition for oral cavity, the effect of improving the sticky feeling in the oral cavity is excellent, and the above-mentioned sustained and excellent refreshing effect is exerted. It has been found that the internal irritation can be suppressed and a good feeling of use can be given, which also increases the effectiveness of halitosis suppression, and it is possible not only to suppress interpersonal halitosis but also to eliminate anxiety of halitosis. Invented the invention.
That is, in the present invention, (A) 0.00001 to 0.05% by mass of a plant extract as a pure extract and (B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide ( 0.00001 to 0.01% by mass of one or more selected from B-1) and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-2) When (A) / (B) is contained in a mass ratio of 0.02 to 100, it has an excellent effect of improving the stickiness in the oral cavity, and has an excellent refreshing effect and a feeling of use. A good oral composition can be provided.
更に詳述すると、後述の比較例にも示すように、（Ａ）成分又は（Ｂ）成分の単独使用では、口腔内のねばつき感改善効果及びすっきり感付与効果がほとんどなかった（比較例１～１５）。よって、この結果からは両者を併用することで両作用効果が向上するとは考えられなかったが、後述の実施例からも明らかなように、本発明では（Ａ）成分と（Ｂ）成分とを組み合わせると、両者の配合量がそれぞれ特定範囲かつ（Ａ）／（Ｂ）の質量比が特定範囲内において、両成分が相乗的に作用し、口腔内刺激を抑えてねばつき感の改善効果及びすっきり感付与効果が共に増強し、格別顕著な作用効果を奏した。このような本発明の作用効果は、（Ａ）及び（Ｂ）成分の組み合わせに特異なものであり、（Ｂ）成分に代えて、同様に冷感又は清涼化作用を有するメントール、ペパーミント油又はモノメンチルサクシネートを（Ａ）成分と併用したのでは劣り（比較例１６～１８）、また、（Ｂ）成分以外のＮ－置換－ｐ－メンタン－カルボキサミドを（Ａ）成分と併用した場合も劣った。
特許文献４～９（特開２０１４－１２５４４０号公報、特開２０１５－１８２９８３号公報、特開２０１６－１０２０７６号公報、特表２０１４－５０７４４０号公報、特表２０１２－５０８７４１号公報、特表２０１１－５２０９２５号公報）は、冷涼化又は清涼化剤のＮ－置換－ｐ－メンタン－カルボキサミドによって清涼感やサッパリ感が改善した口腔用組成物、特許文献１０（特開２０１３－１１２６３４号公報）は、ｐ－メンタン－３，８－ジオール異性体混合物含有の口腔用組成物を開示する。これに対し、本発明は、（Ａ）及び（Ｂ）成分の併用による、口腔内のねばつき感の改善及びすっきり感の付与であり、その技術的思想は特許文献４～１０から予測できない。 More specifically, as shown in the comparative examples described later, the single use of the component (A) or the component (B) has almost no effect on improving the stickiness feeling in the oral cavity and the effect of imparting a refreshing feeling (Comparative Example 1). ~ 15). Therefore, from this result, it was not considered that the combined effect was improved by using both in combination, but as is clear from the examples described later, in the present invention, the components (A) and (B) When combined, both components are in a specific range and the mass ratio of (A) / (B) is in a specific range, both components act synergistically, suppressing oral irritation and improving the sticky feeling Both the refreshing effect was enhanced and the effect was remarkable. Such operational effects of the present invention are specific to the combination of the components (A) and (B), and instead of the component (B), menthol, peppermint oil or Monomenthyl succinate is inferior when used in combination with component (A) (Comparative Examples 16 to 18), and N-substituted-p-menthane-carboxamide other than component (B) may be used in combination with component (A). inferior.
Patent Documents 4 to 9 (JP 2014-125440, JP 2015-182983, JP 2016-102076, JP 2014-507440, JP 2012-508741, JP 2011-11 No. 520925) is a composition for oral cavity whose refreshing feeling and refreshing feeling are improved by N-substituted-p-menthane-carboxamide as a cooling or cooling agent, Patent Document 10 (Japanese Patent Laid-Open No. 2013-112634), An oral composition containing a mixture of p-menthane-3,8-diol isomers is disclosed. On the other hand, the present invention improves the sticky feeling in the oral cavity and imparts a refreshing feeling by the combined use of the components (A) and (B), and its technical idea cannot be predicted from Patent Documents 4 to 10.
特許文献４～９（特開２０１４－１２５４４０号公報、特開２０１５－１８２９８３号公報、特開２０１６－１０２０７６号公報、特表２０１４－５０７４４０号公報、特表２０１２－５０８７４１号公報、特表２０１１－５２０９２５号公報）は、冷涼化又は清涼化剤のＮ－置換－ｐ－メンタン－カルボキサミドによって清涼感やサッパリ感が改善した口腔用組成物、特許文献１０（特開２０１３－１１２６３４号公報）は、ｐ－メンタン－３，８－ジオール異性体混合物含有の口腔用組成物を開示する。これに対し、本発明は、（Ａ）及び（Ｂ）成分の併用による、口腔内のねばつき感の改善及びすっきり感の付与であり、その技術的思想は特許文献４～１０から予測できない。 More specifically, as shown in the comparative examples described later, the single use of the component (A) or the component (B) has almost no effect on improving the stickiness feeling in the oral cavity and the effect of imparting a refreshing feeling (Comparative Example 1). ~ 15). Therefore, from this result, it was not considered that the combined effect was improved by using both in combination, but as is clear from the examples described later, in the present invention, the components (A) and (B) When combined, both components are in a specific range and the mass ratio of (A) / (B) is in a specific range, both components act synergistically, suppressing oral irritation and improving the sticky feeling Both the refreshing effect was enhanced and the effect was remarkable. Such operational effects of the present invention are specific to the combination of the components (A) and (B), and instead of the component (B), menthol, peppermint oil or Monomenthyl succinate is inferior when used in combination with component (A) (Comparative Examples 16 to 18), and N-substituted-p-menthane-carboxamide other than component (B) may be used in combination with component (A). inferior.
Patent Documents 4 to 9 (JP 2014-125440, JP 2015-182983, JP 2016-102076, JP 2014-507440, JP 2012-508741, JP 2011-11 No. 520925) is a composition for oral cavity whose refreshing feeling and refreshing feeling are improved by N-substituted-p-menthane-carboxamide as a cooling or cooling agent, Patent Document 10 (Japanese Patent Laid-Open No. 2013-112634), An oral composition containing a mixture of p-menthane-3,8-diol isomers is disclosed. On the other hand, the present invention improves the sticky feeling in the oral cavity and imparts a refreshing feeling by the combined use of the components (A) and (B), and its technical idea cannot be predicted from Patent Documents 4 to 10.
従って、本発明は、下記の口腔用組成物を提供する。
〔１〕
（Ａ）植物エキスをエキス純分として０．００００１～０．０５質量％と、
（Ｂ）Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）及びＮ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－２）から選ばれる１種以上を０．００００１～０．０１質量％と
を含有し、（Ａ）／（Ｂ）が質量比として０．０２～１００である口腔用組成物。
〔２〕
（Ａ）植物エキスが、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ、キハダ、クロモジ、サンショウ、タイム、シラカバ、シャクヤク、ウラジロガシ、アセンヤク、ウコン、チョウジ、ステビア、ムクロジ、マジョラム、メリッサ、シソ、ローレル、ユーカリ、コーラ、羅漢果、ツバキ、クローブ、オールスパイス、スオウ、シコン、ダイオウ、レンギョウ、チンピ、ケイヒ、オレガノ、バジル、ナギナタコウジュ、ボタンピ及びセイタカミロバランから選ばれる１種以上の植物の抽出エキスである〔１〕に記載の口腔用組成物。
〔３〕
（Ａ）植物エキスが、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ及びキハダから選ばれる１種以上の植物の抽出エキスである〔２〕に記載の口腔用組成物。
〔４〕
更に、（Ｃ）メンチルモノサクシネート、Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミド及びメンチルラクテートから選ばれる１種以上を０．０００１～０．０１質量％含有する〔１〕～〔３〕のいずれかに記載の口腔用組成物。
〔５〕
歯磨剤又は洗口剤である〔１〕～〔４〕のいずれかに記載の口腔用組成物。
〔６〕
歯磨剤であり、更に、（Ｄ）研磨剤を８～７０質量％含有する〔５〕に記載の口腔用組成物。 Accordingly, the present invention provides the following oral composition.
[1]
(A) 0.00001 to 0.05% by mass as a pure extract of plant extract,
(B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide An oral composition containing 0.00001 to 0.01% by mass of one or more selected from (B-2), wherein (A) / (B) is 0.02 to 100 as a mass ratio.
[2]
(A) The plant extract is rosemary, oxon, carrot, sage, licorice, sugar beet, salmon, peanut, olive, tea, yellowfin, black mushroom, salamander, thyme, birch, peonies, flamingo, asenyaku, turmeric, clove, stevia , Mucloj, Marjoram, Melissa, Perilla, Laurel, Eucalyptus, Cola, Luo Hanhua, Camellia, Clove, Allspice, Suou, Shikon, Diou, Forsythia, Chimpi, Keihi, Oregano, Basil, Naginata Koju, Buttonpi and Seitakamiirobaran The composition for oral cavity according to [1], which is an extract of one or more kinds of plants.
[3]
(A) The oral extract according to [2], wherein the plant extract is an extract of one or more kinds of plants selected from rosemary, hornon, carrot, sage, licorice, sugar beet, salmon, jujube, olive, tea and yellowfin Composition.
[4]
Further, it contains 0.0001 to 0.01% by mass of one or more selected from (C) menthyl monosuccinate, N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide and menthyl lactate [1 ] The composition for oral cavity according to any one of [3] to [3].
[5]
The oral composition according to any one of [1] to [4], which is a dentifrice or mouthwash.
[6]
The composition for oral cavity according to [5], which is a dentifrice and further contains (D) 8 to 70% by mass of an abrasive.
〔１〕
（Ａ）植物エキスをエキス純分として０．００００１～０．０５質量％と、
（Ｂ）Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）及びＮ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－２）から選ばれる１種以上を０．００００１～０．０１質量％と
を含有し、（Ａ）／（Ｂ）が質量比として０．０２～１００である口腔用組成物。
〔２〕
（Ａ）植物エキスが、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ、キハダ、クロモジ、サンショウ、タイム、シラカバ、シャクヤク、ウラジロガシ、アセンヤク、ウコン、チョウジ、ステビア、ムクロジ、マジョラム、メリッサ、シソ、ローレル、ユーカリ、コーラ、羅漢果、ツバキ、クローブ、オールスパイス、スオウ、シコン、ダイオウ、レンギョウ、チンピ、ケイヒ、オレガノ、バジル、ナギナタコウジュ、ボタンピ及びセイタカミロバランから選ばれる１種以上の植物の抽出エキスである〔１〕に記載の口腔用組成物。
〔３〕
（Ａ）植物エキスが、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ及びキハダから選ばれる１種以上の植物の抽出エキスである〔２〕に記載の口腔用組成物。
〔４〕
更に、（Ｃ）メンチルモノサクシネート、Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミド及びメンチルラクテートから選ばれる１種以上を０．０００１～０．０１質量％含有する〔１〕～〔３〕のいずれかに記載の口腔用組成物。
〔５〕
歯磨剤又は洗口剤である〔１〕～〔４〕のいずれかに記載の口腔用組成物。
〔６〕
歯磨剤であり、更に、（Ｄ）研磨剤を８～７０質量％含有する〔５〕に記載の口腔用組成物。 Accordingly, the present invention provides the following oral composition.
[1]
(A) 0.00001 to 0.05% by mass as a pure extract of plant extract,
(B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide An oral composition containing 0.00001 to 0.01% by mass of one or more selected from (B-2), wherein (A) / (B) is 0.02 to 100 as a mass ratio.
[2]
(A) The plant extract is rosemary, oxon, carrot, sage, licorice, sugar beet, salmon, peanut, olive, tea, yellowfin, black mushroom, salamander, thyme, birch, peonies, flamingo, asenyaku, turmeric, clove, stevia , Mucloj, Marjoram, Melissa, Perilla, Laurel, Eucalyptus, Cola, Luo Hanhua, Camellia, Clove, Allspice, Suou, Shikon, Diou, Forsythia, Chimpi, Keihi, Oregano, Basil, Naginata Koju, Buttonpi and Seitakamiirobaran The composition for oral cavity according to [1], which is an extract of one or more kinds of plants.
[3]
(A) The oral extract according to [2], wherein the plant extract is an extract of one or more kinds of plants selected from rosemary, hornon, carrot, sage, licorice, sugar beet, salmon, jujube, olive, tea and yellowfin Composition.
[4]
Further, it contains 0.0001 to 0.01% by mass of one or more selected from (C) menthyl monosuccinate, N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide and menthyl lactate [1 ] The composition for oral cavity according to any one of [3] to [3].
[5]
The oral composition according to any one of [1] to [4], which is a dentifrice or mouthwash.
[6]
The composition for oral cavity according to [5], which is a dentifrice and further contains (D) 8 to 70% by mass of an abrasive.
本発明によれば、口臭の原因ともなる口腔内のねばつき感の改善効果が優れ、かつ優れたすっきり感付与効果を有し、使用感も良い口腔用組成物を提供できる。本発明の口腔用組成物は、口臭抑制実感も高く、口臭抑制用として好適に使用できる。
According to the present invention, it is possible to provide an oral composition having an excellent effect of improving the stickiness in the oral cavity that also causes bad breath, an excellent refreshing effect, and good usability. The composition for oral cavity of the present invention has a high feeling of bad breath suppression and can be suitably used for the suppression of bad breath.
以下、本発明につき更に詳述する。本発明の口腔用組成物は、（Ａ）植物エキスと、（Ｂ）Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）及びＮ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－２）から選ばれる１種以上とを、それぞれ特定量かつ特定割合で含有する。
Hereinafter, the present invention will be described in further detail. The composition for oral cavity of the present invention comprises (A) a plant extract, (B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N- (2- ( One or more selected from 2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-2) is contained in a specific amount and a specific ratio.
（Ａ）植物エキスは、植物の抽出エキスであり、（Ｂ）成分と併用することで、口腔内のねばつき感の低減作用を奏する。
ここで、エキスの原料となる植物としては、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿（特に柿のタンニン）、ナタマメ、オリーブ（特にオリーブの葉）、チャ、キハダ（特に樹皮のオウバク）、クロモジ、サンショウ、タイム、シラカバ、シャクヤク、ウラジロガシ、アセンヤク、ウコン、チョウジ、ステビア、ムクロジ、マジョラム、メリッサ、シソ、ローレル、ユーカリ、コーラ、羅漢果、ツバキ、クローブ、オールスパイス、スオウ、シコン、ダイオウ、レンギョウ、チンピ、ケイヒ、オレガノ、バジル、ナギナタコウジュ、ボタンピ、セイタカミロバラン等が挙げられる。これらの中でも、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ、キハダ、クロモジ、サンショウが好ましく、より好ましくはローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ、キハダであり、更に好ましくはローズマリー、オウゴン、ニンジン、セージ、カンゾウである。 (A) A plant extract is an extract of a plant, and when used in combination with the component (B), it reduces the stickiness in the oral cavity.
Here, the plant that is the raw material of the extract is rosemary, hornon, carrot, sage, licorice, sugar beet, persimmon (especially persimmon tannin), jujube, olive (particularly olive leaf), tea, yellowfin (particularly bark) (Owaku), Kuromoji, Salamander, Thyme, Birch, Peonies, Vultures, Asenyaku, Turmeric, Clove, Stevia, Mukuroji, Marjoram, Melissa, Perilla, Laurel, Eucalyptus, Cola, Arachon, Camellia, Clove, Allspice, Suo, Shikon , Daio, Forsythia, Chinpi, Keihi, Oregano, Basil, Naginata Koju, Buttonpi, Seikamirobaran and the like. Among these, rosemary, oxon, carrot, sage, licorice, sugar beet, salmon, jujube, olive, tea, yellowfin, black moji, salamander are preferred, more preferably rosemary, oxon, carrot, sage, licorice, toki, Salmon, jujube, olive, tea, yellowfin, and more preferred are rosemary, orange, carrot, sage, and liquorice.
ここで、エキスの原料となる植物としては、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿（特に柿のタンニン）、ナタマメ、オリーブ（特にオリーブの葉）、チャ、キハダ（特に樹皮のオウバク）、クロモジ、サンショウ、タイム、シラカバ、シャクヤク、ウラジロガシ、アセンヤク、ウコン、チョウジ、ステビア、ムクロジ、マジョラム、メリッサ、シソ、ローレル、ユーカリ、コーラ、羅漢果、ツバキ、クローブ、オールスパイス、スオウ、シコン、ダイオウ、レンギョウ、チンピ、ケイヒ、オレガノ、バジル、ナギナタコウジュ、ボタンピ、セイタカミロバラン等が挙げられる。これらの中でも、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ、キハダ、クロモジ、サンショウが好ましく、より好ましくはローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ、キハダであり、更に好ましくはローズマリー、オウゴン、ニンジン、セージ、カンゾウである。 (A) A plant extract is an extract of a plant, and when used in combination with the component (B), it reduces the stickiness in the oral cavity.
Here, the plant that is the raw material of the extract is rosemary, hornon, carrot, sage, licorice, sugar beet, persimmon (especially persimmon tannin), jujube, olive (particularly olive leaf), tea, yellowfin (particularly bark) (Owaku), Kuromoji, Salamander, Thyme, Birch, Peonies, Vultures, Asenyaku, Turmeric, Clove, Stevia, Mukuroji, Marjoram, Melissa, Perilla, Laurel, Eucalyptus, Cola, Arachon, Camellia, Clove, Allspice, Suo, Shikon , Daio, Forsythia, Chinpi, Keihi, Oregano, Basil, Naginata Koju, Buttonpi, Seikamirobaran and the like. Among these, rosemary, oxon, carrot, sage, licorice, sugar beet, salmon, jujube, olive, tea, yellowfin, black moji, salamander are preferred, more preferably rosemary, oxon, carrot, sage, licorice, toki, Salmon, jujube, olive, tea, yellowfin, and more preferred are rosemary, orange, carrot, sage, and liquorice.
植物エキスの抽出方法は、公知の方法を採用でき、通常の抽出条件で行うことができる。
具体的に、植物エキスは、原料植物、特に葉及び茎を粉砕して粉状にしたものを極性溶媒、非極性溶媒、又は極性溶媒と非極性溶媒との混合溶媒を用いて抽出することにより得ることができる。前記抽出溶媒としては、例えば、水、エチルエーテル、エチレンクロライド、ジオキサン、アセトン、エタノール、メタノール、酢酸エチル、プロピレングリコール、ブチレングリコール、グリセリン等の極性溶媒、もしくはｎ－ヘキサン、石油エーテル、リグロイン、シクロヘキサン、四塩化炭素、クロロホルム、ジクロルメタン、１，２－ジクロルエタン、トルエン、ベンゼン等の非極性溶媒、又はこれらの混合溶媒が挙げられる。
好ましい抽出溶媒としては、水、炭素数１～５の低級一価アルコール（特にメタノール、エタノール、プロパノール、イソプロパノール等）、グリコール（特にプロピレングリコール、ブチレングリコール等）、あるいはこれらの混合溶媒である。混合溶媒は、好ましくは水と低級一価アルコール又はグリコールとの混合比率が１０：９０～９０：１０（質量比）のものである。抽出溶媒は、水のみであってもよい。
また、抽出残渣を原料として、前記溶媒を用いて抽出処理された植物抽出物も、使用することができる。
このような（Ａ）植物エキスは、市販品を使用することもできる。具体的には、丸善製薬（株）、（株）ヤマダ薬研等の市販品を用いることができる。 As a method for extracting a plant extract, a known method can be adopted, and it can be performed under normal extraction conditions.
Specifically, a plant extract is obtained by extracting a raw material plant, particularly a powder obtained by pulverizing leaves and stems, using a polar solvent, a nonpolar solvent, or a mixed solvent of a polar solvent and a nonpolar solvent. Obtainable. Examples of the extraction solvent include polar solvents such as water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol, butylene glycol, and glycerin, or n-hexane, petroleum ether, ligroin, and cyclohexane. , Non-polar solvents such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene and benzene, or a mixed solvent thereof.
Preferred extraction solvents are water, lower monohydric alcohols having 1 to 5 carbon atoms (particularly methanol, ethanol, propanol, isopropanol, etc.), glycols (particularly propylene glycol, butylene glycol, etc.), or a mixed solvent thereof. The mixed solvent preferably has a mixing ratio of water and lower monohydric alcohol or glycol of 10:90 to 90:10 (mass ratio). The extraction solvent may be water alone.
Moreover, the plant extract extracted using the said solvent by using an extraction residue as a raw material can also be used.
A commercial item can also be used for such (A) plant extract. Specifically, commercially available products such as Maruzen Pharmaceutical Co., Ltd. and Yamada Yakuken Co., Ltd. can be used.
具体的に、植物エキスは、原料植物、特に葉及び茎を粉砕して粉状にしたものを極性溶媒、非極性溶媒、又は極性溶媒と非極性溶媒との混合溶媒を用いて抽出することにより得ることができる。前記抽出溶媒としては、例えば、水、エチルエーテル、エチレンクロライド、ジオキサン、アセトン、エタノール、メタノール、酢酸エチル、プロピレングリコール、ブチレングリコール、グリセリン等の極性溶媒、もしくはｎ－ヘキサン、石油エーテル、リグロイン、シクロヘキサン、四塩化炭素、クロロホルム、ジクロルメタン、１，２－ジクロルエタン、トルエン、ベンゼン等の非極性溶媒、又はこれらの混合溶媒が挙げられる。
好ましい抽出溶媒としては、水、炭素数１～５の低級一価アルコール（特にメタノール、エタノール、プロパノール、イソプロパノール等）、グリコール（特にプロピレングリコール、ブチレングリコール等）、あるいはこれらの混合溶媒である。混合溶媒は、好ましくは水と低級一価アルコール又はグリコールとの混合比率が１０：９０～９０：１０（質量比）のものである。抽出溶媒は、水のみであってもよい。
また、抽出残渣を原料として、前記溶媒を用いて抽出処理された植物抽出物も、使用することができる。
このような（Ａ）植物エキスは、市販品を使用することもできる。具体的には、丸善製薬（株）、（株）ヤマダ薬研等の市販品を用いることができる。 As a method for extracting a plant extract, a known method can be adopted, and it can be performed under normal extraction conditions.
Specifically, a plant extract is obtained by extracting a raw material plant, particularly a powder obtained by pulverizing leaves and stems, using a polar solvent, a nonpolar solvent, or a mixed solvent of a polar solvent and a nonpolar solvent. Obtainable. Examples of the extraction solvent include polar solvents such as water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol, butylene glycol, and glycerin, or n-hexane, petroleum ether, ligroin, and cyclohexane. , Non-polar solvents such as carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene and benzene, or a mixed solvent thereof.
Preferred extraction solvents are water, lower monohydric alcohols having 1 to 5 carbon atoms (particularly methanol, ethanol, propanol, isopropanol, etc.), glycols (particularly propylene glycol, butylene glycol, etc.), or a mixed solvent thereof. The mixed solvent preferably has a mixing ratio of water and lower monohydric alcohol or glycol of 10:90 to 90:10 (mass ratio). The extraction solvent may be water alone.
Moreover, the plant extract extracted using the said solvent by using an extraction residue as a raw material can also be used.
A commercial item can also be used for such (A) plant extract. Specifically, commercially available products such as Maruzen Pharmaceutical Co., Ltd. and Yamada Yakuken Co., Ltd. can be used.
（Ａ）植物エキスの配合量は、抽出溶媒を除いたエキス純分として組成物全体の０．００００１～０．０５（質量％、以下同様）であり、好ましくは０．０００１～０．００５％であり、より好ましくは０．０００２～０．００５％である。配合量が０．００００１％未満であると、ねばつき感の改善効果が劣る。０．０５％を超えると、刺激が強すぎる。
The blending amount of the plant extract (A) is 0.00001 to 0.05 (mass%, the same applies hereinafter) of the whole composition as a pure extract excluding the extraction solvent, preferably 0.0001 to 0.005% More preferably, it is 0.0002 to 0.005%. If the blending amount is less than 0.00001%, the effect of improving the sticky feeling is inferior. If it exceeds 0.05%, the stimulation is too strong.
（Ｂ）成分は、Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）及びＮ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－２）から選ばれ、好ましくはＮ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）である。なお、（Ｂ）成分としては、（Ｂ－１）成分又は（Ｂ－２）成分を用いてもよく、また、効果発現の点で（Ｂ－１）及び（Ｂ－２）成分を用いてもよい。
Component (B) is composed of N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5 It is selected from methylcyclohexanecarboxamide (B-2), preferably N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1). As the component (B), the component (B-1) or the component (B-2) may be used, and the components (B-1) and (B-2) are used in terms of the effect. Also good.
（Ｂ）成分の配合量は、組成物全体の０．００００１～０．０１％であり、好ましくは０．００００３～０．００５％である。０．００００１％未満であると、ねばつき感の改善効果及びすっきり感の付与効果が劣る。０．０１％を超えると、刺激が強すぎて後味が悪くなることがある。
なお、（Ｂ－１）成分、（Ｂ－２）成分のそれぞれの配合量は、上記（Ｂ）成分の配合量の範囲内で設定できる。 The blending amount of component (B) is 0.00001 to 0.01%, preferably 0.00003 to 0.005% of the entire composition. If it is less than 0.00001%, the effect of improving the sticky feeling and the effect of imparting a refreshing feeling are inferior. If it exceeds 0.01%, the irritation may be too strong and the aftertaste may deteriorate.
The blending amounts of the component (B-1) and the component (B-2) can be set within the range of the blending amount of the component (B).
なお、（Ｂ－１）成分、（Ｂ－２）成分のそれぞれの配合量は、上記（Ｂ）成分の配合量の範囲内で設定できる。 The blending amount of component (B) is 0.00001 to 0.01%, preferably 0.00003 to 0.005% of the entire composition. If it is less than 0.00001%, the effect of improving the sticky feeling and the effect of imparting a refreshing feeling are inferior. If it exceeds 0.01%, the irritation may be too strong and the aftertaste may deteriorate.
The blending amounts of the component (B-1) and the component (B-2) can be set within the range of the blending amount of the component (B).
本発明において、（Ａ）成分と（Ｂ）成分との配合割合を示す（Ａ）／（Ｂ）は、質量比として０．０２～１００であり、好ましくは０．０５～２０、より好ましくは０．２～５である。この範囲内であると、ねばつき感の改善効果及びすっきり感の付与効果が共に優れ、また、刺激が満足に抑制される。０．０２未満であると、すっきり感の付与効果が十分に持続せず、刺激も強くなる。１００を超えると、刺激が強くなる。
In the present invention, (A) / (B) indicating the blending ratio of the component (A) and the component (B) is 0.02 to 100, preferably 0.05 to 20, more preferably, as a mass ratio. 0.2-5. Within this range, both the effect of improving stickiness and the effect of imparting a refreshing feeling are excellent, and the stimulation is satisfactorily suppressed. If it is less than 0.02, the effect of imparting a refreshing feeling will not be sufficiently maintained, and the stimulation will also be strong. If it exceeds 100, the stimulation becomes stronger.
本発明では、更に、（Ｃ）メンチルモノサクシネート、Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミド及びメンチルラクテートから選ばれる１種又は２種以上を配合することが好ましい。（Ａ）及び（Ｂ）成分に（Ｃ）成分を組み合わせて配合すると、ねばつき感の改善効果が更に高まる。
（Ｃ）成分は、好ましくはメンチルモノサクシネート、Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミドであり、より好ましくはメンチルモノサクシネートである。 In the present invention, it is preferable to further blend one or more selected from (C) menthyl monosuccinate, N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide and menthyl lactate. When the components (A) and (B) are combined with the component (C), the sticky feeling is further improved.
The component (C) is preferably menthyl monosuccinate and N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide, more preferably menthyl monosuccinate.
（Ｃ）成分は、好ましくはメンチルモノサクシネート、Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミドであり、より好ましくはメンチルモノサクシネートである。 In the present invention, it is preferable to further blend one or more selected from (C) menthyl monosuccinate, N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide and menthyl lactate. When the components (A) and (B) are combined with the component (C), the sticky feeling is further improved.
The component (C) is preferably menthyl monosuccinate and N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide, more preferably menthyl monosuccinate.
（Ｃ）成分の配合量は、組成物全体の０．０００１～０．０１％が好ましく、より好ましくは０．０００３～０．００５％である。この範囲内であると、ねばつき感の改善効果が更に向上する。０．０１％を超えると、刺激が強くなって後味が悪くなる場合がある。
The blending amount of the component (C) is preferably 0.0001 to 0.01%, more preferably 0.0003 to 0.005% of the entire composition. Within this range, the effect of improving the stickiness is further improved. If it exceeds 0.01%, the irritation may become strong and the aftertaste may deteriorate.
本発明の口腔用組成物は、固体、液体、液状、ペースト状、ゲル状などの形態に調製し、練歯磨、液体歯磨、液状歯磨、潤製歯磨等の歯磨剤、洗口剤、口中清涼剤などの様々な剤型にすることが可能であるが、特に、歯磨剤又は洗口剤、とりわけ歯磨剤が好適であり、研磨剤を含む練歯磨がよい。その製造方法は剤型に応じた常法を採用できる。
更に、本発明では、組成物の目的、剤型等に応じて、上述した成分以外にも適宜な公知成分を、本発明の効果を損なわない範囲で必要に応じて配合できる。例えば、練歯磨剤の場合は、研磨剤、粘結剤、湿潤剤、界面活性剤、甘味剤、防腐剤、ｐＨ調整剤、香料、薬効成分等が挙げられる。洗口剤の場合は、湿潤剤、界面活性剤、甘味剤、防腐剤、ｐＨ調整剤、香料、薬効成分等が挙げられる。 The composition for oral cavity of the present invention is prepared in the form of solid, liquid, liquid, paste, gel, etc., and is used for toothpastes such as toothpastes, liquid dentifrices, liquid dentifrices, moisturized dentifrices, mouthwashes, and refreshments in the mouth. It is possible to use various dosage forms such as an agent, but in particular, a dentifrice or a mouthwash, especially a dentifrice is suitable, and a toothpaste containing an abrasive is good. The manufacturing method can employ a conventional method according to the dosage form.
Furthermore, in this invention, according to the objective of a composition, a dosage form, etc., an appropriate well-known component can be mix | blended as needed in the range which does not impair the effect of this invention other than the component mentioned above. For example, in the case of a toothpaste, examples thereof include abrasives, binders, wetting agents, surfactants, sweeteners, preservatives, pH adjusters, fragrances, and medicinal ingredients. In the case of a mouthwash, examples include a wetting agent, a surfactant, a sweetener, an antiseptic, a pH adjuster, a fragrance, and a medicinal component.
更に、本発明では、組成物の目的、剤型等に応じて、上述した成分以外にも適宜な公知成分を、本発明の効果を損なわない範囲で必要に応じて配合できる。例えば、練歯磨剤の場合は、研磨剤、粘結剤、湿潤剤、界面活性剤、甘味剤、防腐剤、ｐＨ調整剤、香料、薬効成分等が挙げられる。洗口剤の場合は、湿潤剤、界面活性剤、甘味剤、防腐剤、ｐＨ調整剤、香料、薬効成分等が挙げられる。 The composition for oral cavity of the present invention is prepared in the form of solid, liquid, liquid, paste, gel, etc., and is used for toothpastes such as toothpastes, liquid dentifrices, liquid dentifrices, moisturized dentifrices, mouthwashes, and refreshments in the mouth. It is possible to use various dosage forms such as an agent, but in particular, a dentifrice or a mouthwash, especially a dentifrice is suitable, and a toothpaste containing an abrasive is good. The manufacturing method can employ a conventional method according to the dosage form.
Furthermore, in this invention, according to the objective of a composition, a dosage form, etc., an appropriate well-known component can be mix | blended as needed in the range which does not impair the effect of this invention other than the component mentioned above. For example, in the case of a toothpaste, examples thereof include abrasives, binders, wetting agents, surfactants, sweeteners, preservatives, pH adjusters, fragrances, and medicinal ingredients. In the case of a mouthwash, examples include a wetting agent, a surfactant, a sweetener, an antiseptic, a pH adjuster, a fragrance, and a medicinal component.
研磨剤としては、第２リン酸カルシウム・２水和塩又は無水和物、第１リン酸カルシウム、第３リン酸カルシウム、ピロリン酸カルシウム等のリン酸カルシウム系化合物；沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のシリカ系研磨剤；炭酸カルシウム等の炭酸カルシウム系研磨剤；水酸化カルシウム、水酸化アルミニウム、第３リン酸マグネシウム、炭酸マグネシウム、硫酸カルシウム、ベントナイト、ハイドロキシアパタイトが挙げられ、これらの１種又は２種以上を配合できる。これらの中では、特に沈降性シリカ、アルミノシリケート、ジルコノシリケート、チタン結合性シリカ等のケイ酸塩を主成分とするシリカ系研磨剤や炭酸カルシウム系研磨剤、とりわけ沈降性シリカ等のシリカ系研磨剤が好ましい。
Examples of abrasives include calcium phosphate compounds such as dicalcium phosphate dihydrate or anhydrous, primary calcium phosphate, tertiary calcium phosphate, and calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, etc. Silica-based abrasives; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, and one or two of these More than seeds can be blended. Among these, silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, especially silica-based materials such as precipitated silica. Abrasives are preferred.
研磨剤、特に沈降性シリカは、粒径が１～４０μｍである研磨粒子が好ましく、また更に、ＢＥＴ比表面積は１ｇあたり８０～２５０平方メートルであることが好ましい。前記粒径は、粒度分布測定装置（日機装（株）製、マイクロトラック粒度分布計、分散媒；水）による測定値である。
このようなシリカ系研磨剤としては、市販品を使用でき、例えば、ＨＵＢＥＲ社製のＺｅｏｄｅｎｔ１２４、Ｚｅｏｄｅｎｔ１１３、Ｒｈｏｄｉａ社製のＴＩＸＯＳＩＬ ７３、ＴＩＸＯＳＩＬ ６３、Ｄｅｇｕｓｓａ社製のＳｉｄｅｎｔ ３、Ｓｉｄｅｎｔ ２０、多木化学（株）製のジルコノシリケート、アルミノシリケート等が挙げられる。
研磨剤の配合量は、組成物全体の８～７０％、特に１０～５０％が好ましい。 The abrasive, particularly the precipitated silica, is preferably abrasive particles having a particle size of 1 to 40 μm, and the BET specific surface area is preferably 80 to 250 square meters per gram. The particle size is a value measured by a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium: water).
As such a silica-based abrasive, commercially available products can be used. For example, Zeodent 124, Zeodent 113 manufactured by HUBER, TIXOSIL 73, TIXOSIL 63 manufactured by Rhodia, Sident 3, Sident 20, manufactured by Degussa, Taki Chemical ( Zirconosilicate, aluminosilicate, etc. manufactured by Co., Ltd. are mentioned.
The blending amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the whole composition.
このようなシリカ系研磨剤としては、市販品を使用でき、例えば、ＨＵＢＥＲ社製のＺｅｏｄｅｎｔ１２４、Ｚｅｏｄｅｎｔ１１３、Ｒｈｏｄｉａ社製のＴＩＸＯＳＩＬ ７３、ＴＩＸＯＳＩＬ ６３、Ｄｅｇｕｓｓａ社製のＳｉｄｅｎｔ ３、Ｓｉｄｅｎｔ ２０、多木化学（株）製のジルコノシリケート、アルミノシリケート等が挙げられる。
研磨剤の配合量は、組成物全体の８～７０％、特に１０～５０％が好ましい。 The abrasive, particularly the precipitated silica, is preferably abrasive particles having a particle size of 1 to 40 μm, and the BET specific surface area is preferably 80 to 250 square meters per gram. The particle size is a value measured by a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium: water).
As such a silica-based abrasive, commercially available products can be used. For example, Zeodent 124, Zeodent 113 manufactured by HUBER, TIXOSIL 73, TIXOSIL 63 manufactured by Rhodia, Sident 3, Sident 20, manufactured by Degussa, Taki Chemical ( Zirconosilicate, aluminosilicate, etc. manufactured by Co., Ltd. are mentioned.
The blending amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the whole composition.
また、研磨剤は顆粒状であってもよく、研磨性を有する成分として、顆粒を配合できる。顆粒は、水不溶性粉体を顆粒状に形成させた粒子であり、シリカゲルを破砕した顆粒や粒状化に結合剤を用いた造粒物でもよい。
研磨剤は、上述の粒径１～４０μｍの研磨粒子と上述の顆粒を併用してもよい。 The abrasive may be granular, and granules can be blended as an abrasive component. The granule is a particle obtained by forming a water-insoluble powder into a granule, and may be a granule obtained by crushing silica gel or a granulated product using a binder for granulation.
As the abrasive, the above-mentioned abrasive particles having a particle diameter of 1 to 40 μm and the above-mentioned granules may be used in combination.
研磨剤は、上述の粒径１～４０μｍの研磨粒子と上述の顆粒を併用してもよい。 The abrasive may be granular, and granules can be blended as an abrasive component. The granule is a particle obtained by forming a water-insoluble powder into a granule, and may be a granule obtained by crushing silica gel or a granulated product using a binder for granulation.
As the abrasive, the above-mentioned abrasive particles having a particle diameter of 1 to 40 μm and the above-mentioned granules may be used in combination.
粘結剤としては、キサンタンガム、カルボキシメチルセルロースナトリウム、ポリアクリル酸ナトリウム、アルギン酸ナトリウム、ポリビニルピロリドン、カラギーナン、メチルセルロース、ヒドロキシエチルセルロースナトリウム、トラガントガム、カラヤガム、アラビヤガム、ローカストビーンガム、ポリビニルアルコール、カルボキシビニルポリマー、カーボポール、ビーガム、アルギン酸プロピレングリコール等の有機粘結剤、増粘性シリカ、ケイ酸アルミニウム等の無機粘結剤が配合できる。これらは１種又は２種以上で使用できる。粘結剤の配合量は、有機粘結剤の場合、組成物全体の０．８～５％、特に１～３％が好ましく、無機粘結剤の場合、組成物全体の０．５～１０％、特に１～８％が好ましい。
As binder, xanthan gum, sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, caraya gum, arabiya gum, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbopol Organic binders such as bee gum and propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate can be blended. These can be used alone or in combination of two or more. In the case of an organic binder, the blending amount of the binder is preferably 0.8 to 5%, particularly 1 to 3%, and in the case of an inorganic binder, 0.5 to 10% of the whole composition. %, Particularly 1 to 8% is preferred.
湿潤剤としては、ソルビット、キシリット等の糖アルコール、プロピレングリコール、グリセリン等の多価アルコールが挙げられる。配合量は通常、組成物全体の５～５０％、特に２０～４５％である。
Examples of the wetting agent include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as propylene glycol and glycerin. The blending amount is usually 5 to 50%, particularly 20 to 45% of the whole composition.
界面活性剤としては、アニオン性界面活性剤、ノニオン性界面活性剤、両性界面活性剤が挙げられる。特に、アニオン性界面活性剤が好ましい。
アニオン性界面活性剤としては、アルキル硫酸塩、α－オレフィンスルホン酸塩、水素添加ココナッツ脂肪酸モノグリセリドモノ硫酸塩、ラウリルスルホ酢酸塩、Ｎ－メチル－Ｎ－アシルタウリン塩等のＮ－アシルタウリン塩、アシルサルコシン塩、Ｎ－アシル－Ｌ－グルタミン酸塩等のアシルアミノ酸塩が挙げられる。これらは１種又は２種以上で使用できる。中でも、泡立ち、泡質の良さの点で、スルホン酸基を含有するアニオン性界面活性剤が好ましく、より好ましくはアルキル硫酸塩、α－オレフィンスルホン酸塩である。前記塩としては、ナトリウム塩、カリウム塩、アンモニウム塩等が挙げられ、特にナトリウム塩が好ましい。
アルキル硫酸塩は、アルキル基の炭素数が好ましくは１２～１４であり、具体的には、アルキル硫酸塩としてラウリル硫酸ナトリウム、ミリストイル硫酸ナトリウムが挙げられる。 Examples of the surfactant include an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant. In particular, an anionic surfactant is preferable.
Anionic surfactants include alkyl sulfates, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-acyl taurine salts such as N-methyl-N-acyl taurate, Examples include acyl amino acid salts such as acyl sarcosine salt and N-acyl-L-glutamate. These can be used alone or in combination of two or more. Among these, anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of foaming and foam quality, and alkyl sulfates and α-olefin sulfonates are more preferable. Examples of the salt include sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.
In the alkyl sulfate, the alkyl group preferably has 12 to 14 carbon atoms. Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
アニオン性界面活性剤としては、アルキル硫酸塩、α－オレフィンスルホン酸塩、水素添加ココナッツ脂肪酸モノグリセリドモノ硫酸塩、ラウリルスルホ酢酸塩、Ｎ－メチル－Ｎ－アシルタウリン塩等のＮ－アシルタウリン塩、アシルサルコシン塩、Ｎ－アシル－Ｌ－グルタミン酸塩等のアシルアミノ酸塩が挙げられる。これらは１種又は２種以上で使用できる。中でも、泡立ち、泡質の良さの点で、スルホン酸基を含有するアニオン性界面活性剤が好ましく、より好ましくはアルキル硫酸塩、α－オレフィンスルホン酸塩である。前記塩としては、ナトリウム塩、カリウム塩、アンモニウム塩等が挙げられ、特にナトリウム塩が好ましい。
アルキル硫酸塩は、アルキル基の炭素数が好ましくは１２～１４であり、具体的には、アルキル硫酸塩としてラウリル硫酸ナトリウム、ミリストイル硫酸ナトリウムが挙げられる。 Examples of the surfactant include an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant. In particular, an anionic surfactant is preferable.
Anionic surfactants include alkyl sulfates, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-acyl taurine salts such as N-methyl-N-acyl taurate, Examples include acyl amino acid salts such as acyl sarcosine salt and N-acyl-L-glutamate. These can be used alone or in combination of two or more. Among these, anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of foaming and foam quality, and alkyl sulfates and α-olefin sulfonates are more preferable. Examples of the salt include sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.
In the alkyl sulfate, the alkyl group preferably has 12 to 14 carbon atoms. Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
α－オレフィンスルホン酸塩としては、炭素数が１４～１６のα－オレフィンスルホン酸のナトリウム、カリウム等のアルカリ金属塩を用いることができ、中でも炭素数１４のα－オレフィンスルホン酸塩、特にナトリウム塩（一般名；テトラデセンスルホン酸ナトリウム）が好ましい。
界面活性剤、特にアニオン性界面活性剤の配合量は、例えば歯磨剤の場合は、組成物全体の０．６～２．５％が好ましく、より好ましくは１～２．５％である。洗口剤の場合は、組成物全体の０～１．０％、特に０～０．３％が好ましい。 As the α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonate having 14 to 16 carbon atoms can be used, and among them, α-olefin sulfonate having 14 carbon atoms, particularly sodium. Salts (generic name; sodium tetradecene sulfonate) are preferred.
In the case of dentifrice, for example, the amount of the surfactant, particularly an anionic surfactant, is preferably 0.6 to 2.5%, more preferably 1 to 2.5% of the whole composition. In the case of a mouthwash, 0 to 1.0%, particularly 0 to 0.3% of the whole composition is preferable.
界面活性剤、特にアニオン性界面活性剤の配合量は、例えば歯磨剤の場合は、組成物全体の０．６～２．５％が好ましく、より好ましくは１～２．５％である。洗口剤の場合は、組成物全体の０～１．０％、特に０～０．３％が好ましい。 As the α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonate having 14 to 16 carbon atoms can be used, and among them, α-olefin sulfonate having 14 carbon atoms, particularly sodium. Salts (generic name; sodium tetradecene sulfonate) are preferred.
In the case of dentifrice, for example, the amount of the surfactant, particularly an anionic surfactant, is preferably 0.6 to 2.5%, more preferably 1 to 2.5% of the whole composition. In the case of a mouthwash, 0 to 1.0%, particularly 0 to 0.3% of the whole composition is preferable.
甘味剤としては、サッカリンナトリウム、ステビオサイド、ステビアエキス、パラメトキシシンナミックアルデヒド、ネオヘスペリジルジヒドロカルコン、ペリラルチン、グリチルリチン、ソーマチン、アスパラチルフェニルアラニンメチルエステル等が挙げられる。防腐剤としては、パラオキシ安息香酸エステル、安息香酸ナトリウム等が挙げられる。
ｐＨ調整剤としては、クエン酸、乳酸等の有機酸やその塩類；塩酸、水酸化ナトリウム、水酸化カリウム、リン酸水素二ナトリウム、リン酸二水素ナトリウム等の無機化合物が挙げられる。 Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like. Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
ｐＨ調整剤としては、クエン酸、乳酸等の有機酸やその塩類；塩酸、水酸化ナトリウム、水酸化カリウム、リン酸水素二ナトリウム、リン酸二水素ナトリウム等の無機化合物が挙げられる。 Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like. Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
香料としては、公知の口腔用香料、例えばメントール、アネトール、カルボン、オイゲノール、リモネン、ｎ－デシルアルコール、シトロネロール、α－テルピネオール、シトロネリルアセテート、シネオール、リナロール、エチルリナロール、ワニリン、チモール、スペアミント油、ペパーミント油、レモン油、オレンジ油、セージ油、ローズマリー油、桂皮油、ピメント油、桂葉油、シソ油、冬緑油、丁字油、ユーカリ油等が挙げられる。
As the fragrance, known oral fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, Peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like.
薬効成分としては、デキストラナーゼ、アミラーゼ、プロテアーゼ、ムタナーゼ等の酵素；トラネキサム酸、イプシロンアミノカプロン酸、アズレン、グリチルリチン酸塩、グリチルレチン酸塩等の抗炎症剤；塩化ナトリウム、ビタミン類、アラントイン類等の細胞賦活剤；イソプロピルメチルフェノール、塩化セチルピリジニウム、塩化ベンザルコニウム、ヒノキチオール、塩化リゾチーム等の殺菌剤；銅クロロフィル、グルコン酸銅等の水溶性銅化合物；歯石予防剤；ビタミンＥ等の血行促進剤；アラニン、グリシン、プロリン等のアミノ酸類を配合できる。なお、薬効成分の配合量は、本発明の効果を妨げない範囲で有効量とすることができる。
Medicinal ingredients include enzymes such as dextranase, amylase, protease, mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate; sodium chloride, vitamins, allantoins, etc. Cell activators; bactericides such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; calculus prophylaxis; blood circulation promoters such as vitamin E Amino acids such as alanine, glycine and proline can be blended. In addition, the compounding quantity of a medicinal ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.
更に、任意成分として、雲母チタン、酸化チタン、ベントナイト等の無機化合物；結晶性セルロース等のセルロース系の有機粉末；寒天、ゼラチン、デンプン、グルコマンナン等の天然高分子化合物；ポリ酢酸ビニル、アクリル樹脂、ポリウレタン、ポリエステル、ポリ塩化ビニル、ナイロン末、ポリエチレン末等の合成高分子化合物又はそれらの共重合体；カルナバワックス、ロジン、ライスワックス、マイクロクリスタリンワックス、ミツロウ、パラフィンワックス等のワックス類；セタノール、ステアリルアルコール等の高級アルコール；ポリイソブチレン、ポリブタジエン、シリコーン、天然ゴムを、本発明の効果を妨げない範囲で配合することができる。
なお、溶剤としては、精製水が一般的に用いられる。また、エタノール等の炭素数１～３の低級一価アルコールを配合してもよい。前記低級一価アルコールの配合量は組成物全体の０～１０％がよい。 Further, as optional components, inorganic compounds such as titanium mica, titanium oxide, bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, glucomannan; polyvinyl acetate, acrylic resin Synthetic polymers such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.
As the solvent, purified water is generally used. Further, a lower monohydric alcohol having 1 to 3 carbon atoms such as ethanol may be blended. The amount of the lower monohydric alcohol is preferably 0 to 10% of the entire composition.
なお、溶剤としては、精製水が一般的に用いられる。また、エタノール等の炭素数１～３の低級一価アルコールを配合してもよい。前記低級一価アルコールの配合量は組成物全体の０～１０％がよい。 Further, as optional components, inorganic compounds such as titanium mica, titanium oxide, bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, glucomannan; polyvinyl acetate, acrylic resin Synthetic polymers such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.
As the solvent, purified water is generally used. Further, a lower monohydric alcohol having 1 to 3 carbon atoms such as ethanol may be blended. The amount of the lower monohydric alcohol is preferably 0 to 10% of the entire composition.
以下、実施例及び比較例、処方例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、下記の例において％は特に断らない限りいずれも質量％を示す。
Hereinafter, although an Example, a comparative example, and a formulation example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.
［実施例、比較例］
表１～６に示す組成の歯磨剤組成物（練歯磨）又は洗口剤をそれぞれ常法によって調製し、通常の口腔用製剤容器（練歯磨：ラミネートチューブ、洗口剤：ボトル）に収容した。これらをサンプルとして用い、下記に示す方法で評価した。結果を表１～６に併記した。表中の（Ａ）成分の配合量の数値は、抽出溶媒を除いたエキス純分量である。 [Examples and Comparative Examples]
Dentifrice compositions (toothpaste) or mouthwashes having the compositions shown in Tables 1 to 6 were prepared by conventional methods and stored in ordinary oral preparation containers (toothpaste: laminate tube, mouthwash: bottle). . These were used as samples and evaluated by the methods shown below. The results are shown in Tables 1-6. The numerical value of the blending amount of the component (A) in the table is the pure extract amount excluding the extraction solvent.
表１～６に示す組成の歯磨剤組成物（練歯磨）又は洗口剤をそれぞれ常法によって調製し、通常の口腔用製剤容器（練歯磨：ラミネートチューブ、洗口剤：ボトル）に収容した。これらをサンプルとして用い、下記に示す方法で評価した。結果を表１～６に併記した。表中の（Ａ）成分の配合量の数値は、抽出溶媒を除いたエキス純分量である。 [Examples and Comparative Examples]
Dentifrice compositions (toothpaste) or mouthwashes having the compositions shown in Tables 1 to 6 were prepared by conventional methods and stored in ordinary oral preparation containers (toothpaste: laminate tube, mouthwash: bottle). . These were used as samples and evaluated by the methods shown below. The results are shown in Tables 1-6. The numerical value of the blending amount of the component (A) in the table is the pure extract amount excluding the extraction solvent.
＜使用した原料＞
（Ａ）成分
《Ａ１：ローズマリーエキス》
商品名：ローズマリー抽出物－Ｊ、抽出溶媒：５０％エタノール、使用部位：葉
メーカー：丸善製薬（株）
《Ａ２：オウゴンエキス》
商品名：オウゴン抽出物－Ｊ、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ３：ニンジンエキス》
商品名：ニンジン抽出物、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ４：セージエキス》
商品名：サルビア抽出物、抽出溶媒：５０％エタノール、使用部位：葉
メーカー：丸善製薬（株）
《Ａ５：カンゾウエキス》
商品名：カンゾウ抽出物、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ６：ナタマメエキス》
商品名：ＡＯＦ ナタマメエキス－ＨＢＧ、抽出溶媒：５０％１，３－ブチレングリコール、使用部位：種子
メーカー：（株）ヤマダ薬研
《Ａ７：柿タンニンエキス》
商品名：パンシル ＢＡ－２００Ｅ－１、抽出溶媒：水、使用部位：果実
メーカー：リリース科学工業
《Ａ８：トウキエキス》
商品名：トウキ抽出物－ＪＣ、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ９：オリーブ葉エキス》
商品名：オリーブ抽出物－ＢＧ、抽出溶媒：５０％ブチレングリコール、使用部位：葉
メーカー：丸善製薬（株） <Used raw materials>
(A) component << A1: Rosemary extract >>
Product name: Rosemary extract-J, extraction solvent: 50% ethanol, application site: leaf manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A2: Ogon Extract >>
Product name: Ougon extract-J, extraction solvent: 50% ethanol, application site: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A3: Carrot extract >>
Product name: carrot extract, extraction solvent: 50% ethanol, use site: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A4: Sage extract >>
Product name: Salvia extract, extraction solvent: 50% ethanol, application site: leaf manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A5: Daylily extract >>
Product name: Licorice extract, extraction solvent: 50% ethanol, application site: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
"A6: Bean extract"
Product name: AOF Solid bean extract-HBG, extraction solvent: 50% 1,3-butylene glycol, site of use: seed manufacturer: Yamada Yakuken Co., Ltd. << A7: salmon tannin extract >>
Product name: Pancil BA-200E-1, Extraction solvent: Water, Use site: Fruit manufacturer: Release Kagaku Kogyo << A8: Toki extract >>
Product name: Toki extract-JC, extraction solvent: 50% ethanol, site of use: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A9: Olive leaf extract >>
Product Name: Olive Extract-BG, Extraction Solvent: 50% Butylene Glycol, Application Site: Leaf Manufacturer: Maruzen Pharmaceutical Co., Ltd.
（Ａ）成分
《Ａ１：ローズマリーエキス》
商品名：ローズマリー抽出物－Ｊ、抽出溶媒：５０％エタノール、使用部位：葉
メーカー：丸善製薬（株）
《Ａ２：オウゴンエキス》
商品名：オウゴン抽出物－Ｊ、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ３：ニンジンエキス》
商品名：ニンジン抽出物、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ４：セージエキス》
商品名：サルビア抽出物、抽出溶媒：５０％エタノール、使用部位：葉
メーカー：丸善製薬（株）
《Ａ５：カンゾウエキス》
商品名：カンゾウ抽出物、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ６：ナタマメエキス》
商品名：ＡＯＦ ナタマメエキス－ＨＢＧ、抽出溶媒：５０％１，３－ブチレングリコール、使用部位：種子
メーカー：（株）ヤマダ薬研
《Ａ７：柿タンニンエキス》
商品名：パンシル ＢＡ－２００Ｅ－１、抽出溶媒：水、使用部位：果実
メーカー：リリース科学工業
《Ａ８：トウキエキス》
商品名：トウキ抽出物－ＪＣ、抽出溶媒：５０％エタノール、使用部位：根
メーカー：丸善製薬（株）
《Ａ９：オリーブ葉エキス》
商品名：オリーブ抽出物－ＢＧ、抽出溶媒：５０％ブチレングリコール、使用部位：葉
メーカー：丸善製薬（株） <Used raw materials>
(A) component << A1: Rosemary extract >>
Product name: Rosemary extract-J, extraction solvent: 50% ethanol, application site: leaf manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A2: Ogon Extract >>
Product name: Ougon extract-J, extraction solvent: 50% ethanol, application site: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A3: Carrot extract >>
Product name: carrot extract, extraction solvent: 50% ethanol, use site: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A4: Sage extract >>
Product name: Salvia extract, extraction solvent: 50% ethanol, application site: leaf manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A5: Daylily extract >>
Product name: Licorice extract, extraction solvent: 50% ethanol, application site: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
"A6: Bean extract"
Product name: AOF Solid bean extract-HBG, extraction solvent: 50% 1,3-butylene glycol, site of use: seed manufacturer: Yamada Yakuken Co., Ltd. << A7: salmon tannin extract >>
Product name: Pancil BA-200E-1, Extraction solvent: Water, Use site: Fruit manufacturer: Release Kagaku Kogyo << A8: Toki extract >>
Product name: Toki extract-JC, extraction solvent: 50% ethanol, site of use: root manufacturer: Maruzen Pharmaceutical Co., Ltd.
<< A9: Olive leaf extract >>
Product Name: Olive Extract-BG, Extraction Solvent: 50% Butylene Glycol, Application Site: Leaf Manufacturer: Maruzen Pharmaceutical Co., Ltd.
（Ｂ）成分
《Ｂ１：Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド》
商品名：エバクールＧ－１８０、メーカー：ジボダンジャパン社
《Ｂ２：Ｎ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド》
商品名：エバクールＧ－１９０、メーカー：ジボダンジャパン社 Component (B) << B1: N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide >>
Product name: Ebacool G-180, manufacturer: Givadan Japan Co., Ltd. << B2: N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide >>
Product name: Evercool G-190, Manufacturer: Givaudan Japan
《Ｂ１：Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド》
商品名：エバクールＧ－１８０、メーカー：ジボダンジャパン社
《Ｂ２：Ｎ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド》
商品名：エバクールＧ－１９０、メーカー：ジボダンジャパン社 Component (B) << B1: N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide >>
Product name: Ebacool G-180, manufacturer: Givadan Japan Co., Ltd. << B2: N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide >>
Product name: Evercool G-190, Manufacturer: Givaudan Japan
（Ｃ）成分
《Ｃ１：メンチルモノサクシネート》
商品名：フィスクール、メーカー：ヴェマンフィス社
《Ｃ２：Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミド》
商品名：ＷＳ－５、メーカー：シムライズ社
《Ｃ３：メンチルラクテート》
商品名：フレスコラットＭＬ、メーカー：シムライズ社
なお、香料は、後述の表７～１５に示す香料組成物Ａ～Ｐを各々使用した。 (C) Component << C1: Menthyl monosuccinate >>
Product name: Fischer, manufacturer: Vemanfiss Co., Ltd. << C2: N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide >>
Product name: WS-5, manufacturer: Simrise Co., Ltd. << C3: Menthyl lactate >>
Product name: Fresco Rat ML, manufacturer: Simrise Co., Ltd. Note that the fragrance compositions A to P shown in Tables 7 to 15 described below were used.
《Ｃ１：メンチルモノサクシネート》
商品名：フィスクール、メーカー：ヴェマンフィス社
《Ｃ２：Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミド》
商品名：ＷＳ－５、メーカー：シムライズ社
《Ｃ３：メンチルラクテート》
商品名：フレスコラットＭＬ、メーカー：シムライズ社
なお、香料は、後述の表７～１５に示す香料組成物Ａ～Ｐを各々使用した。 (C) Component << C1: Menthyl monosuccinate >>
Product name: Fischer, manufacturer: Vemanfiss Co., Ltd. << C2: N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide >>
Product name: WS-5, manufacturer: Simrise Co., Ltd. << C3: Menthyl lactate >>
Product name: Fresco Rat ML, manufacturer: Simrise Co., Ltd. Note that the fragrance compositions A to P shown in Tables 7 to 15 described below were used.
＜評価方法＞
被験者４名によって評価した。
歯ブラシ（クリニカアドバンテージ歯ブラシ、４列コンパクトふつう、ライオン（株）製）にサンプルの歯磨剤組成物１ｇを載せ、３分間歯みがきを行った後、１０ｍＬの水で１回、口腔内をすすいだ。サンプルが洗口剤の場合は１０ｍＬを口に含み、３０秒間洗口したのちに吐出した。使用後の口腔内のねばつき感、使用して６０分間経過後の口腔内のすっきり感、口腔内刺激（使用直後の口腔内での刺激感のなさ）を、それぞれ下記の評点基準によって判定し、４名の平均点を求め、下記の評価基準で評価した。 <Evaluation method>
Evaluation was performed by 4 subjects.
1 g of the sample dentifrice composition was placed on a toothbrush (Clinica Advantage toothbrush, 4 rows compact normal, manufactured by Lion Corporation), brushed for 3 minutes, and then rinsed once in the mouth with 10 mL of water. When the sample was a mouthwash, 10 mL was contained in the mouth, and after 30 minutes of mouthwashing, the sample was discharged. The stickiness feeling in the oral cavity after use, the refreshing feeling in the oral cavity after 60 minutes of use, and the oral stimulation (the absence of irritation in the oral cavity immediately after use) are determined according to the following criteria. The average score of 4 people was calculated and evaluated according to the following evaluation criteria.
被験者４名によって評価した。
歯ブラシ（クリニカアドバンテージ歯ブラシ、４列コンパクトふつう、ライオン（株）製）にサンプルの歯磨剤組成物１ｇを載せ、３分間歯みがきを行った後、１０ｍＬの水で１回、口腔内をすすいだ。サンプルが洗口剤の場合は１０ｍＬを口に含み、３０秒間洗口したのちに吐出した。使用後の口腔内のねばつき感、使用して６０分間経過後の口腔内のすっきり感、口腔内刺激（使用直後の口腔内での刺激感のなさ）を、それぞれ下記の評点基準によって判定し、４名の平均点を求め、下記の評価基準で評価した。 <Evaluation method>
Evaluation was performed by 4 subjects.
1 g of the sample dentifrice composition was placed on a toothbrush (Clinica Advantage toothbrush, 4 rows compact normal, manufactured by Lion Corporation), brushed for 3 minutes, and then rinsed once in the mouth with 10 mL of water. When the sample was a mouthwash, 10 mL was contained in the mouth, and after 30 minutes of mouthwashing, the sample was discharged. The stickiness feeling in the oral cavity after use, the refreshing feeling in the oral cavity after 60 minutes of use, and the oral stimulation (the absence of irritation in the oral cavity immediately after use) are determined according to the following criteria. The average score of 4 people was calculated and evaluated according to the following evaluation criteria.
＜口腔内のねばつき感＞
評点基準
５：全く感じない
４：あまり感じない
３：どちらともいえない
２：やや感じる
１：非常に感じる
評価基準
◎：４点以上
○：３点以上４点未満
×：３点未満 <A feeling of stickiness in the oral cavity>
Rating criteria 5: I don't feel at all 4: I don't feel very much 3: I can't say either 2: Slightly feel 1: I feel very much Evaluation criteria ◎: More than 4 points ○: More than 3 points and less than 4 points ×: Less than 3 points
評点基準
５：全く感じない
４：あまり感じない
３：どちらともいえない
２：やや感じる
１：非常に感じる
評価基準
◎：４点以上
○：３点以上４点未満
×：３点未満 <A feeling of stickiness in the oral cavity>
Rating criteria 5: I don't feel at all 4: I don't feel very much 3: I can't say either 2: Slightly feel 1: I feel very much Evaluation criteria ◎: More than 4 points ○: More than 3 points and less than 4 points ×: Less than 3 points
＜口腔内のすっきり感＞
評点基準
５：非常に感じる
４：感じる
３：どちらともいえない
２：あまり感じない
１：全く感じない
評価基準
◎：４点以上
○：３点以上４点未満
×：３点未満 <A refreshing feeling in the oral cavity>
Rating criteria 5: Feel very much 4: Feel 3: Not say 2: Not feel very much 1: Not feel at all Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points
評点基準
５：非常に感じる
４：感じる
３：どちらともいえない
２：あまり感じない
１：全く感じない
評価基準
◎：４点以上
○：３点以上４点未満
×：３点未満 <A refreshing feeling in the oral cavity>
Rating criteria 5: Feel very much 4: Feel 3: Not say 2: Not feel very much 1: Not feel at all Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points
＜口腔内刺激＞
評点基準
５：全く感じない
４：あまり感じない
３：どちらともいえない
２：やや感じる
１：非常に感じる
評価基準
◎：４点以上
○：３点以上４点未満
×：３点未満 <Oral stimulation>
Rating criteria 5: I don't feel at all 4: I don't feel very much 3: I can't say either 2: Slightly feel 1: I feel very much Evaluation criteria ◎: More than 4 points ○: More than 3 points and less than 4 points ×: Less than 3 points
評点基準
５：全く感じない
４：あまり感じない
３：どちらともいえない
２：やや感じる
１：非常に感じる
評価基準
◎：４点以上
○：３点以上４点未満
×：３点未満 <Oral stimulation>
Rating criteria 5: I don't feel at all 4: I don't feel very much 3: I can't say either 2: Slightly feel 1: I feel very much Evaluation criteria ◎: More than 4 points ○: More than 3 points and less than 4 points ×: Less than 3 points
以下に処方例を示す。使用原料は上記と同様である。
A prescription example is shown below. The raw materials used are the same as described above.
［処方例１］歯磨剤
（Ａ）Ａ１：ローズマリーエキス エキス純分として０．０００２％
（Ｂ）Ｂ１：Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－
メチルシクロヘキサンカルボキサミド ０．００１
（Ｃ）Ｃ１：メンチルモノサクシネート ０．０００５
（Ｃ）Ｃ３：メンチルラクテート ０．０００３
（Ｄ）研磨性シリカ １５
ソルビット液（７０％） ３０
プロピレングリコール ４
増粘性シリカ ４
キサンタンガム １．５
ラウリル硫酸ナトリウム １．５
フッ化ナトリウム ０．２
サッカリンナトリウム ０．２
香料 １
水 残部
計 １００％
（Ａ）／（Ｂ）＝０．２ [Formulation Example 1] Dentifrice (A) A1: Rosemary Extract 0.0002% as a pure extract
(B) B1: N- (4-cyanomethylphenyl) -2-isopropyl-5
Methylcyclohexanecarboxamide 0.001
(C) C1: Menthyl monosuccinate 0.0005
(C) C3: Menthyl lactate 0.0003
(D) Abrasive silica 15
Sorbit liquid (70%) 30
Propylene glycol 4
Thickening silica 4
Xanthan gum 1.5
Sodium lauryl sulfate 1.5
Sodium fluoride 0.2
Saccharin sodium 0.2
Fragrance 1
Water balance
Total 100%
(A) / (B) = 0.2
（Ａ）Ａ１：ローズマリーエキス エキス純分として０．０００２％
（Ｂ）Ｂ１：Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－
メチルシクロヘキサンカルボキサミド ０．００１
（Ｃ）Ｃ１：メンチルモノサクシネート ０．０００５
（Ｃ）Ｃ３：メンチルラクテート ０．０００３
（Ｄ）研磨性シリカ １５
ソルビット液（７０％） ３０
プロピレングリコール ４
増粘性シリカ ４
キサンタンガム １．５
ラウリル硫酸ナトリウム １．５
フッ化ナトリウム ０．２
サッカリンナトリウム ０．２
香料 １
水 残部
計 １００％
（Ａ）／（Ｂ）＝０．２ [Formulation Example 1] Dentifrice (A) A1: Rosemary Extract 0.0002% as a pure extract
(B) B1: N- (4-cyanomethylphenyl) -2-isopropyl-5
Methylcyclohexanecarboxamide 0.001
(C) C1: Menthyl monosuccinate 0.0005
(C) C3: Menthyl lactate 0.0003
(D) Abrasive silica 15
Sorbit liquid (70%) 30
Propylene glycol 4
Thickening silica 4
Xanthan gum 1.5
Sodium lauryl sulfate 1.5
Sodium fluoride 0.2
Saccharin sodium 0.2
Fragrance 1
Water balance
Total 100%
(A) / (B) = 0.2
［処方例２］洗口剤
（Ａ）Ａ１：ローズマリーエキス エキス純分として０．０００２％
（Ｂ）Ｂ２：Ｎ－（２－（２－ピリジニル）エチル）－２－イソプロピル－
５－メチルシクロヘキサンカルボキサミド ０．００５
（Ｃ）Ｃ１：メンチルモノサクシネート ０．０００５
（Ｃ）Ｃ３：メンチルラクテート ０．０００３
エタノール ２．０
メントール ０．０６
クエン酸 ０．０５
クエン酸ナトリウム ０．３
ポリオキシエチレン（６０）硬化ヒマシ油 ０．５
塩化セチルピリジニウム ０．０５
パラオキシ安息香酸メチル ０．２５
香料 １
水 残部
計 １００％
（Ａ）／（Ｂ）＝０．０４ [Prescription Example 2] Mouthwash (A) A1: Rosemary extract 0.0002% as pure extract
(B) B2: N- (2- (2-pyridinyl) ethyl) -2-isopropyl-
5-methylcyclohexanecarboxamide 0.005
(C) C1: Menthyl monosuccinate 0.0005
(C) C3: Menthyl lactate 0.0003
Ethanol 2.0
Menthol 0.06
Citric acid 0.05
Sodium citrate 0.3
Polyoxyethylene (60) hydrogenated castor oil 0.5
Cetylpyridinium chloride 0.05
Methyl paraoxybenzoate 0.25
Fragrance 1
Water balance
Total 100%
(A) / (B) = 0.04
（Ａ）Ａ１：ローズマリーエキス エキス純分として０．０００２％
（Ｂ）Ｂ２：Ｎ－（２－（２－ピリジニル）エチル）－２－イソプロピル－
５－メチルシクロヘキサンカルボキサミド ０．００５
（Ｃ）Ｃ１：メンチルモノサクシネート ０．０００５
（Ｃ）Ｃ３：メンチルラクテート ０．０００３
エタノール ２．０
メントール ０．０６
クエン酸 ０．０５
クエン酸ナトリウム ０．３
ポリオキシエチレン（６０）硬化ヒマシ油 ０．５
塩化セチルピリジニウム ０．０５
パラオキシ安息香酸メチル ０．２５
香料 １
水 残部
計 １００％
（Ａ）／（Ｂ）＝０．０４ [Prescription Example 2] Mouthwash (A) A1: Rosemary extract 0.0002% as pure extract
(B) B2: N- (2- (2-pyridinyl) ethyl) -2-isopropyl-
5-methylcyclohexanecarboxamide 0.005
(C) C1: Menthyl monosuccinate 0.0005
(C) C3: Menthyl lactate 0.0003
Ethanol 2.0
Menthol 0.06
Citric acid 0.05
Sodium citrate 0.3
Polyoxyethylene (60) hydrogenated castor oil 0.5
Cetylpyridinium chloride 0.05
Methyl paraoxybenzoate 0.25
Fragrance 1
Water balance
Total 100%
(A) / (B) = 0.04
［処方例３］洗口剤
（Ａ）Ａ１：ローズマリーエキス エキス純分として０．０００２％
（Ｂ）Ｂ２：Ｎ－（２－（２－ピリジニル）エチル）－２－イソプロピル－
５－メチルシクロヘキサンカルボキサミド ０．００５
（Ｃ）Ｃ１：メンチルモノサクシネート ０．０００５
（Ｃ）Ｃ３：メンチルラクテート ０．０００３
プロピレングリコール ３．０
メントール ０．０６
クエン酸 ０．０５
クエン酸ナトリウム ０．３
ポリオキシエチレン（６０）硬化ヒマシ油 ０．５
塩化セチルピリジニウム ０．０５
パラオキシ安息香酸メチル ０．２５
香料 １
水 残部
計 １００％
（Ａ）／（Ｂ）＝０．０４ [Prescription Example 3] Mouthwash (A) A1: Rosemary extract 0.0002% as pure extract
(B) B2: N- (2- (2-pyridinyl) ethyl) -2-isopropyl-
5-methylcyclohexanecarboxamide 0.005
(C) C1: Menthyl monosuccinate 0.0005
(C) C3: Menthyl lactate 0.0003
Propylene glycol 3.0
Menthol 0.06
Citric acid 0.05
Sodium citrate 0.3
Polyoxyethylene (60) hydrogenated castor oil 0.5
Cetylpyridinium chloride 0.05
Methyl paraoxybenzoate 0.25
Fragrance 1
Water balance
Total 100%
(A) / (B) = 0.04
（Ａ）Ａ１：ローズマリーエキス エキス純分として０．０００２％
（Ｂ）Ｂ２：Ｎ－（２－（２－ピリジニル）エチル）－２－イソプロピル－
５－メチルシクロヘキサンカルボキサミド ０．００５
（Ｃ）Ｃ１：メンチルモノサクシネート ０．０００５
（Ｃ）Ｃ３：メンチルラクテート ０．０００３
プロピレングリコール ３．０
メントール ０．０６
クエン酸 ０．０５
クエン酸ナトリウム ０．３
ポリオキシエチレン（６０）硬化ヒマシ油 ０．５
塩化セチルピリジニウム ０．０５
パラオキシ安息香酸メチル ０．２５
香料 １
水 残部
計 １００％
（Ａ）／（Ｂ）＝０．０４ [Prescription Example 3] Mouthwash (A) A1: Rosemary extract 0.0002% as pure extract
(B) B2: N- (2- (2-pyridinyl) ethyl) -2-isopropyl-
5-methylcyclohexanecarboxamide 0.005
(C) C1: Menthyl monosuccinate 0.0005
(C) C3: Menthyl lactate 0.0003
Propylene glycol 3.0
Menthol 0.06
Citric acid 0.05
Sodium citrate 0.3
Polyoxyethylene (60) hydrogenated castor oil 0.5
Cetylpyridinium chloride 0.05
Methyl paraoxybenzoate 0.25
Fragrance 1
Water balance
Total 100%
(A) / (B) = 0.04
Claims (6)
- （Ａ）植物エキスをエキス純分として０．００００１～０．０５質量％と、
（Ｂ）Ｎ－（４－シアノメチルフェニル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－１）及びＮ－（２－（２－ピリジニル）エチル）－２－イソプロピル－５－メチルシクロヘキサンカルボキサミド（Ｂ－２）から選ばれる１種以上を０．００００１～０．０１質量％と
を含有し、（Ａ）／（Ｂ）が質量比として０．０２～１００である口腔用組成物。 (A) 0.00001 to 0.05% by mass as a pure extract of plant extract,
(B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide An oral composition containing 0.00001 to 0.01% by mass of one or more selected from (B-2), wherein (A) / (B) is 0.02 to 100 as a mass ratio. - （Ａ）植物エキスが、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ、キハダ、クロモジ、サンショウ、タイム、シラカバ、シャクヤク、ウラジロガシ、アセンヤク、ウコン、チョウジ、ステビア、ムクロジ、マジョラム、メリッサ、シソ、ローレル、ユーカリ、コーラ、羅漢果、ツバキ、クローブ、オールスパイス、スオウ、シコン、ダイオウ、レンギョウ、チンピ、ケイヒ、オレガノ、バジル、ナギナタコウジュ、ボタンピ及びセイタカミロバランから選ばれる１種以上の植物の抽出エキスである請求項１記載の口腔用組成物。 (A) The plant extract is rosemary, oxon, carrot, sage, licorice, sugar beet, salmon, peanut, olive, tea, yellowfin, black mushroom, salamander, thyme, birch, peonies, flamingo, asenyaku, turmeric, clove, stevia , Mucloj, Marjoram, Melissa, Perilla, Laurel, Eucalyptus, Cola, Luo Hanhua, Camellia, Clove, Allspice, Suou, Shikon, Diou, Forsythia, Chimpi, Keihi, Oregano, Basil, Naginata Koju, Buttonpi and Seitakamiirobaran The composition for oral cavity according to claim 1, which is an extract of one or more kinds of plants.
- （Ａ）植物エキスが、ローズマリー、オウゴン、ニンジン、セージ、カンゾウ、トウキ、柿、ナタマメ、オリーブ、チャ及びキハダから選ばれる１種以上の植物の抽出エキスである請求項２記載の口腔用組成物。 (A) The composition for oral cavity according to claim 2, wherein the plant extract is an extract of one or more plants selected from rosemary, hornon, carrot, sage, licorice, sugarcane, salmon, jujube, olive, tea and yellowfin. object.
- 更に、（Ｃ）メンチルモノサクシネート、Ｎ－｛（エトキシカルボニル）メチル｝－ｐ－メンタン－３－カルボキサミド及びメンチルラクテートから選ばれる１種以上を０．０００１～０．０１質量％含有する請求項１～３のいずれか１項記載の口腔用組成物。 The composition further comprises 0.0001 to 0.01% by mass of one or more selected from (C) menthyl monosuccinate, N-{(ethoxycarbonyl) methyl} -p-menthane-3-carboxamide and menthyl lactate. The oral composition according to any one of 1 to 3.
- 歯磨剤又は洗口剤である請求項１～４のいずれか１項記載の口腔用組成物。 The composition for oral cavity according to any one of claims 1 to 4, which is a dentifrice or a mouthwash.
- 歯磨剤であり、更に、（Ｄ）研磨剤を８～７０質量％含有する請求項５記載の口腔用組成物。 The oral composition according to claim 5, which is a dentifrice and further contains (D) 8 to 70% by mass of an abrasive.
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|---|---|---|---|---|
| WO2021235424A1 (en) * | 2020-05-18 | 2021-11-25 | ライオン株式会社 | Composition for oral cavity |
| WO2022030559A1 (en) * | 2020-08-05 | 2022-02-10 | ライオン株式会社 | Oral liquid composition |
| WO2022122144A1 (en) | 2020-12-09 | 2022-06-16 | Symrise Ag | A method for fighting microorganisms using menthol derivatives |
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| CN110691583A (en) | 2020-01-14 |
| JPWO2018221621A1 (en) | 2020-04-02 |
| JP7264049B2 (en) | 2023-04-25 |
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