JP7163623B2 - Dentifrice composition and unpleasant taste reducer - Google Patents

Description

TECHNICAL FIELD The present invention relates to a dentifrice composition that reduces the unpleasant taste derived from bicarbonate, provides a refreshing feeling and cleansing feeling, and has a good feeling of use, and an agent for reducing the unpleasant taste.

Since prevention of halitosis is one of the important etiquettes in recent years, there are high expectations for preparations for oral cavity that are excellent in preventing halitosis. This trend is particularly noticeable among young people.

Conventionally, means for suppressing the generation of halitosis by sterilizing halitosis-causing bacteria with bactericides and using deodorants such as enzymes and rosemary extracts are known, and a certain halitosis-preventing effect can be obtained. In addition, means for cleaning the oral cavity using condensed phosphate or the like is also effective in preventing bad breath.
However, in recent years, there have been an increasing number of cases where users who are sensitive to odor suffer from halitosis, which actually does not pose a problem to others. This is considered to be halitosis anxiety caused by perception of a slight odor remaining in one's own oral cavity and discomfort in the oral cavity.
Conventional oral compositions intended to prevent halitosis provide a certain degree of feeling of halitosis prevention (feeling effective that halitosis is suppressed or prevented) during or immediately after use in the oral cavity. It is difficult to say that the sense of prevention is sufficient.

In Patent Document 1 (JP 2003-231621 A), polyphosphate and hydrogen carbonate are used in combination with a water-soluble copper compound, and in Patent Document 2 (JP 10-212220 A), non-bacterial agents are used. By using an ionic surfactant and / or an amphoteric surfactant and an alkali metal bicarbonate and / or carbonate in combination, the durability of the anti-halitosis effect of the oral composition is improved. Not sure about the feeling.

On the other hand, it is thought that providing a sense of freshness and cleanliness in the oral cavity leads to a sense of prevention of halitosis. Sodium hydrogen carbonate, which is a hydrogen carbonate, has a peculiar taste, but gives a refreshing feeling in the oral cavity. are proposed to provide an oral composition that suppresses mucosal irritation and maintains a refreshing feeling in the oral cavity. Furthermore, so-called baking soda dentifrice, which contains sodium hydrogen carbonate as an abrasive, has a certain effect of refreshing the oral cavity, but sodium hydrogen carbonate does not necessarily provide a sufficient feeling of suppressing bad breath. In some cases, it is not suitable for low-irritation formulations, which have been in high demand in recent years.

Japanese Patent Application Laid-Open No. 2003-231621 JP-A-10-212220 JP-A-11-49654 JP 2014-125440 A JP 2015-182983 A JP 2016-102076 A Japanese translation of PCT publication No. 2014-507440 Japanese Patent Publication No. 2012-508741 Japanese Patent Publication No. 2011-520925

The present invention has been made in view of the above circumstances, and provides a dentifrice composition that reduces the unpleasant taste derived from bicarbonate, provides a sufficient refreshing feeling in the oral cavity and a high cleaning feeling, and has a good feeling in use, and an agent for reducing the unpleasant taste. intended to provide

As a result of intensive studies to achieve the above object, the inventors of the present invention have found that the offensive taste caused by bicarbonate and the combined use of a specific N-substituted-p-menthane-carboxamide enhances the offensive taste. Also, the unpleasant taste is reduced by blending a citrus flavor and monomenthyl succinate, and it is possible to obtain a dentifrice composition that gives a refreshing feeling and cleaning feeling in the oral cavity and further improves the feeling of use. rice field.
That is, in the present invention, in particular, (A) a dentifrice composition containing a hydrogen carbonate (A-1), or (A) a hydrogen carbonate (A-1) and (D) N-(4-cyanomethylphenyl )-2-isopropyl-5-methylcyclohexanecarboxamide, (E) a citrus fragrance and (F) monomenthyl succinate are blended into the dentifrice composition, so that components (E) and (F) Disgust derived from the component (A) or the components (A) and (D) is suppressed and reduced, and a sufficient refreshing feeling and a high cleaning feeling can be imparted to the oral cavity, and the flavor expression can be maintained, resulting in a feeling of use. was found to be excellent, and came to make the present invention.

In addition, even without using a bactericide or a water-soluble copper compound for preventing or suppressing bad breath as described in Patent Documents 1 and 2, the present invention can provide an excellent feeling of cleaning the oral cavity and preventing bad breath. . In addition, Patent Documents 4 to 9 (JP 2014-125440, 2015-182983, 2016-102076; JP 2014-507440, 2012-508741, 2011-520925), Oral compositions containing N-substituted-p-menthane-carboxamides are disclosed, which are improved cooling or freshness due to the cooling or refreshing N-substituted-p-menthane-carboxamides. In contrast to these, the present invention is a combination system of the components (E) and (F), which reduces the unpleasant taste of the component (A-1) and improves the feeling of freshness and cleaning of the oral cavity.

Accordingly, the present invention provides the following dentifrice compositions and offensive taste reducing agents.
[1]
A dentifrice composition containing (A) a hydrogen carbonate (A-1), (E) a citrus fragrance and (F) a monomenthyl succinate.
[2]
(A) hydrogen carbonate (A-1), (D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide, (E) citrus fragrance and (F) monomenthyl succinate A dentifrice composition containing:
[3]
(D) The dentifrice composition according to [2], containing 0.00001 to 0.01% by mass of component.
[4]
[1] to [3] containing 0.01 to 10% by mass of component (A), 0.0001 to 0.5% by mass of component (E), and 0.001 to 1% by mass of component (F) A dentifrice composition according to any one of the above.
[5]
(E) The dentifrice composition according to any one of [1] to [4], wherein the citrus flavor is a grapefruit flavor.
[6]
The dentifrice composition according to any one of [1] to [5], further comprising a surfactant.
[7]
(E) a citrus flavor and (F) a monomenthyl succinate, (A) a bicarbonate (A-1) disgusting reducing agent.
[8]
(A) The offensive taste reducing agent by (A) hydrogen carbonate (A-1) according to [7], which is for a dentifrice composition containing component (A).
[9]
(A) bicarbonate (A-1) and (D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexane, consisting of (E) a citrus fragrance and (F) monomenthyl succinate A carboxamide-based sarcasm reducer.
[10]
(A) Hydrogen carbonate (A-1) and (D) N-(4-cyanomethylphenyl)-2 according to [9], which is for a dentifrice composition containing components (A) and (D) - Disgust reducer with isopropyl-5-methylcyclohexanecarboxamide.

According to the present invention, it is possible to provide a dentifrice composition that reduces the unpleasant taste derived from bicarbonate, imparts a sufficient refreshing feeling in the oral cavity and a high feeling of cleaning, and has a good feeling in use. This dentifrice composition can give the feeling of preventing halitosis, and can also be used as a halitosis-preventing preparation for eliminating halitosis anxiety of users who are sensitive to bad breath, which has been increasing in recent years.

The present invention will be described in further detail below. The dentifrice composition of the present invention contains (A) hydrogen carbonate (A-1), (E) citrus flavor and (F) monomenthyl succinate, and further (D) N-(4-cyano methylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide can also be included.

The component (A) is a hydrogen carbonate (A-1).
Sodium hydrogen carbonate can be used as the hydrogen carbonate (A-1).
The amount of the hydrogen carbonate (A-1) is preferably 0.01 to 10% (% by mass, the same shall apply hereinafter) of the entire composition, more preferably 0.1 to 10%, still more preferably 0.3 to 5%. When the amount is 0.01% or more, a sufficient refreshing feeling is obtained, and when it is 10% or less, the unpleasant taste is sufficiently suppressed.

A surfactant can be added to the dentifrice composition of the present invention. The surfactant is preferably an anionic surfactant or a nonionic surfactant, particularly from the point of view of cleaning the oral cavity.
Examples of anionic surfactants include alkyl sulfates such as lauryl sulfate and myristyl sulfate, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, and N-methyl-N-acyl taurine. N-acyl taurine salts such as salts, acyl sarcosine salts such as lauroyl sarcosine salts, and acyl amino acid salts such as N-acyl-L-glutamate. Salts include alkali metal salts such as sodium salts. Among them, sodium lauryl sulfate which is an alkyl sulfate, sodium α-olefin sulfonate which is an α-olefin sulfonate, sodium lauroyl sarcosinate which is an acyl sarcosine salt, and particularly sodium lauryl sulfate are preferred from the viewpoint of suppressing irritation.

The content of the anionic surfactant is preferably 1 to 3%, more preferably 1.4 to 2.5%, still more preferably 1.4 to 2.0% of the total composition. When the blending amount is 1% or more, a sufficient sensation of cleaning the oral cavity can be obtained. When the content is 3% or less, the feeling of irritation caused by itself can be suppressed and the feeling of use can be maintained satisfactorily.

The nonionic surfactant is preferably one or more selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether and polyglycerin fatty acid ester. Among them, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and particularly polyoxyethylene hydrogenated castor oil are preferred from the viewpoint of suppressing irritation.
The average number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil (hereinafter abbreviated as EO) is preferably 10 to 60 moles.
E. of polyoxyethylene alkyl ethers. O. is preferably 2 to 25 mol, and the number of carbon atoms in the alkyl group is preferably 12 to 18.
The polyglycerol fatty acid ester preferably has a fatty acid having 12 to 18 carbon atoms.

The nonionic surfactant content is preferably 0.1 to 1%, more preferably 0.3 to 1% of the total composition. When it is 0.1% or more, a sufficient feeling of cleaning the oral cavity is obtained, and when it is 1% or less, the feeling of cleaning the oral cavity is sufficiently maintained.

In addition, in the present invention, nonionic surfactants other than those described above may be blended as long as the effects of the present invention are not impaired. Specifically, polyoxyethylene fatty acid esters; sucrose fatty acid esters such as maltose fatty acid esters; sugar alcohol fatty acid esters such as maltitol fatty acid esters and lactitol fatty acid esters; oxyethylene sorbitan fatty acid esters; fatty acid diethanolamides such as lauric acid mono- or diethanolamide; sorbitan fatty acid esters; polyoxyethylene-polyoxypropylene copolymers; When these nonionic surfactants are blended, their blending amount is preferably 3% or less, particularly preferably 1% or less, of the entire composition, or may be 0% without blending.

In the present invention, when (D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide is blended, the blending amount is preferably 0.00001 to 0.01% of the total composition. , more preferably 0.00005 to 0.005%. When it is 0.00001% or more, a sufficient refreshing feeling can be obtained. When it is 0.01% or less, sufficient flavor expression can be obtained, and the feeling of irritation due to itself can be suppressed, and the feeling of use can be maintained satisfactorily.
When an N-substituted-p-menthane-carboxamide other than component (D) is used instead of component (D), the effect of the present invention may be inferior.

In the present invention, (E) a citrus fragrance is further blended.
The (A) hydrogen carbonate (A-1) used in the present invention gives a refreshing feeling in the oral cavity, but has a peculiar unpleasant taste, especially (D) N-(4-cyanomethylphenyl)-2- When used in combination with isopropyl-5-methylcyclohexanecarboxamide, the offensive taste derived from the hydrogen carbonate (A-1) tends to increase. However, by using the component (E), even if the offensive taste is enhanced by the combined use of the component (D), the offensive taste derived from the hydrogen carbonate (A-1) is reduced, which is preferable.

As citrus-based fragrances, fragrances such as grapefruit, lemon, and orange are preferred. Examples include lemon oil, refined lemon oil, orange oil, refined orange oil, grapefruit oil, refined grapefruit oil, lemon flavor, orange flavor, grapefruit flavor, etc., and one or more selected from these can be used. Among them, the preferred citrus flavor is grapefruit flavor. It is particularly preferred that the grapefruit flavor contains nootkatone.

(E) The content of the citrus fragrance is preferably 0.0001 to 0.5%, particularly preferably 0.001 to 0.2%, based on the total composition. Within this range, the sarcasm can be sufficiently reduced. When the blending amount is 0.001% or more, the offensive taste is sufficiently suppressed, and sufficient flavor expression can be obtained. When it is 0.5% or less, the flavor expression can be sufficiently maintained.

In the present invention, (F) monomenthyl succinate is blended in addition to (E) a citrus fragrance.
In the present invention, it is more preferable to contain (F) monomenthyl succinate, because not only can the effect of suppressing the unpleasant taste derived from the hydrogen carbonate (A-1) be obtained, but also the feeling of cleaning the oral cavity can be improved. In particular, when (F) monomenthyl succinate is used in combination with (E) a citrus flavor, the effect of component (E) in reducing unpleasant taste is further improved, the flavor expression is good, and the feeling of cleaning the oral cavity is further enhanced.

The content of (F) monomenthyl succinate is preferably 0.001 to 1%, more preferably 0.001 to 1.0%, and particularly preferably 0.01 to 0.1% of the total composition. Within this range, it is possible to sufficiently suppress the unpleasant feeling and sufficiently improve the feeling of cleaning the oral cavity. When the blending amount is 0.001% or more, a sufficient sensation of cleaning the oral cavity can be obtained. If it is 1% or less, the sarcasm can be sufficiently suppressed.

In the present invention, in addition to the components (E) and (F), perfumes other than these can also be used. Other fragrances include known fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyllinalool, vanillin, thymol, spearmint oil, Peppermint oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil and the like. The amount of these perfumes to be blended is a normal amount within a range that does not impair the effects of the present invention.

The dentifrice composition of the present invention can be in the form of a paste, a liquid such as a liquid, or the like, and can be made into various dosage forms such as toothpaste, liquid dentifrice, liquid dentifrice, and wet dentifrice. can be prepared by the method In addition to the above ingredients, other known ingredients that are usually used in dentifrice compositions can be blended as needed within a range that does not impair the effects of the present invention. Optional ingredients that can be blended include abrasives, binders, wetting agents, surfactants other than anionic surfactants and nonionic surfactants, sweeteners, preservatives, pH adjusters, and medicinal ingredients. be done.

Abrasives include calcium phosphate-based compounds such as dicalcium phosphate dihydrate or anhydrate, monocalcium phosphate, tricalcium phosphate, and calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, etc. calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, magnesium tertiary phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite; More than seeds can be blended. Among these, silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, and especially silica-based abrasives such as precipitated silica, etc. Abrasives are preferred.

The abrasive, especially precipitated silica, is preferably abrasive particles having a particle size of 1-40 μm and a BET specific surface area of 80-250 square meters per gram. The particle size is a value measured by a particle size distribution analyzer (Microtrac particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium: water).
As such silica-based abrasives, commercially available products can be used. Co., Ltd. zirconosilicate, aluminosilicate and the like.
The compounding amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the total composition.

Also, the abrasive may be in the form of granules, and granules can be blended as a component having abrasive properties. The granules are particles obtained by forming water-insoluble powder into granules, and granulation using a binder may be used for granulation.

Binders include xanthan gum, sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, karaya gum, arabic gum, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbopol. , Veegum and propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate. These can be used alone or in combination of two or more. The blending amount of these binders is preferably 0.8 to 5%, particularly preferably 1 to 3%, of the total composition in the case of an organic binder, and 0.5 to 0.5% of the total composition in the case of an inorganic binder. 10%, especially 1 to 8% is preferred.

Wetting agents include sugar alcohols such as sorbitol and xylite, and polyhydric alcohols such as propylene glycol and glycerin. The amount is usually 5-50%, especially 20-45% of the total composition.

As the surfactant, an amphoteric surfactant can be blended. Specific examples include fatty acid amidopropyl betaine such as cocamidopropyl betaine; alkylbetaine such as lauryldimethylaminoacetate betaine; and imidazoline type amphoteric surfactant such as coconut oil fatty acid imidazolium betaine.

Sweetening agents include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perraltin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like.
Examples of antiseptics include paraoxybenzoic acid esters, benzoic acid, salts thereof, and the like.

Examples of pH adjusters include organic acids such as citric acid and lactic acid, salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

Fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate; enzymes such as dextranase, amylase, protease, and mutanase; tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate, etc. anti-inflammatory agents; sodium chloride, vitamins, cell activators such as allantoin; bactericidal agents such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; water solutions such as copper chlorophyll and copper gluconate anticalculus agents such as zeolite; blood circulation promoters such as vitamin E; and amino acids such as alanine, glycine, and proline. The amount of the medicinal ingredient can be an effective amount within a range that does not impair the effects of the present invention.

Furthermore, as optional ingredients, inorganic compounds such as mica titanium, titanium oxide, and bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, and glucomannan; polyvinyl acetate, and acrylic resins. , synthetic polymer compounds such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder, or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.

Further, in the present invention, (A) a disgusting taste reducing agent by a hydrogen carbonate (A-1), which consists of (E) a citrus flavor and (F) monomenthyl succinate, and the above components (E) and (F) (A) bicarbonate (A-1) and (D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide to provide an offensive taste reducing agent consisting of: The disgusting taste reducing agent is for a dentifrice composition containing components (A) ((A-1)) and a dentifrice composition containing components (A) ((A-1)) and (D). It is suitable for use.
In these cases, the components (E) and (F) are the active ingredients of the offensive taste reducing agent, and can be used as the offensive taste reducing agent consisting only of the above active ingredients. Furthermore, it is possible to prepare a dentifrice composition containing the components (E) and (F) as active ingredients for reducing unpleasant taste. Details such as the compounding amount of each component are the same as those described for the dentifrice composition.

EXAMPLES Hereinafter, the present invention will be specifically described by showing examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
Dentifrice compositions having compositions shown in Tables 1 to 3 were prepared by a conventional method. The resulting dentifrice composition was used as a sample and evaluated by the following methods. The results are also shown in Tables 1-3.

<Evaluation method>
Four subject panelists evaluated the feeling of use of the dentifrice composition. 1 g of the sample dentifrice composition was placed on a toothbrush (clinica advantage toothbrush, 4-row compact regular type, manufactured by Lion Corporation) and brushed for 3 minutes.
After rinsing (after rinsing the oral cavity with water after brushing the teeth), the feeling of cleaning the oral cavity was evaluated according to the following rating criteria. The average score of four persons was calculated and evaluated according to the following evaluation criteria.
Here, the feeling of cleaning the oral cavity is a feeling that the oral cavity has been cleaned and becomes clean.

Oral cleaning experience Scoring criteria 1: Did not feel 2: Neither 3: Somewhat felt 4: Felt 5: Strongly felt Evaluation criteria ◎: Average score of 4 people is 4 points or more Average score of 3 or more and less than 4 points △: Average score of 4 people is 2 or more and less than 3 points ×: Average score of 4 people is less than 2 points

Further, 10 subjects put 1 g of the dentifrice composition on the same toothbrush as above and brushed their teeth for 3 minutes. The refreshing feeling after rinsing, the lack of unpleasant taste during toothbrushing (offensive taste derived from bicarbonate), and the flavor development were evaluated according to the following rating criteria. The average score of 10 persons was calculated and evaluated according to the following evaluation criteria.

Refreshing feeling Rating criteria 4: Strongly felt 3: Slightly felt 1: Did not feel Evaluation criteria ◎: Average score of 3.5 or more ○: Average score of 3.0 or more and less than 3.5 △ : Average score of 2.0 or more and less than 3.0 ×: Average score of less than 2.0

Absence of sarcasm Scoring criteria 4: No sarcasm 3: Almost no sarcasm 2: Slightly sarcasm 1: Somewhat sarcasm Evaluation criteria ◎: Average score of 3.5 points or more ○: Average score of 3.0 points 3.5 points or more △: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

Flavor expression Rating criteria 4: Very good 3: Good 2: Somewhat bad 1: Bad Evaluation criteria ◎: Average score of 3.5 points or more ○: Average score of 3.0 or more and less than 3.5 points △: Average Points 2.0 or more and less than 3.0 points ×: Average score less than 2.0 points

Details of raw materials used are shown below.
(A) ((A-1))
Sodium hydrogen carbonate: sodium bicarbonate (manufactured by Asahi Glass Co., Ltd.)
(D)
N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide: Evacool 180 (manufactured by Givaudan Japan Co., Ltd.)
(E)
Grapefruit fragrance: Grapefruit oil (manufactured by Taiyo Fragrance Co., Ltd.)
(F)
Monomenthyl succinate: Monomenthyl succinate (Ve Man Fiss Fragrance (
Co., Ltd.)
Sodium lauryl sulfate: Texapon (manufactured by BASF)
Polyoxyethylene (20) hydrogenated castor oil:
NIKKOL HCO-20 (manufactured by Nikko Chemicals Co., Ltd., average added mole number of ethylene oxide: 20)

*；Reference example

As a result of using the dentifrice composition of the example, the feeling of cleaning the oral cavity and the refreshing feeling are excellent, the unpleasant taste derived from bicarbonate is sufficiently suppressed, and the flavor expression is high, and it is refreshing and very good use. It was evaluated that it was a feeling.

Claims (7)

(A) bicarbonate, (D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide, (E) citrus fragrance and (F) monomenthyl succinate , (A ) ) A dentifrice composition in which the content of the component is 0.1 to 5% by mass . The dentifrice composition according to claim 1 , containing 0.00001 to 0.01% by mass of component (D). 3. The dentifrice composition according to claim 1, comprising 0.0001 to 0.5% by mass of component ( E) and 0.001 to 1% by mass of component (F). (E) The dentifrice composition according to any one of claims 1 to 3 , wherein the citrus flavor is grapefruit flavor. The dentifrice composition according to any one of claims 1 to 4 , further comprising a surfactant. (E) citrus flavor and (F) monomenthyl succinate, (A) bicarbonate and (D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexane carboxamide reducing agent. (A) the hydrogen carbonate according to claim 6, which contains components (A) and (D) and is for a dentifrice composition in which the content of component (A) is 0.1 to 5% by mass; (D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide unpleasant taste reducing agent.