JP7088179B2 - Toothpaste composition - Google Patents

Description

The present invention relates to a dentifrice composition having a good usability.

In recent years, since halitosis prevention is one of the important etiquettes, there are high expectations for oral preparations that have an excellent halitosis prevention feeling. This tendency is particularly noticeable among young people.

Conventionally, a means for suppressing the generation of halitosis by sterilizing the bacteria causing halitosis with a bactericidal agent and using a deodorant such as an enzyme or rosemary extract has been known, and a certain halitosis preventive effect can be obtained. Further, a means for cleaning the oral cavity using condensed phosphate or the like is also effective for preventing bad breath.
However, in recent years, there are an increasing number of odor-sensitive users who suffer from bad breath even though it does not actually pose a problem to others. It is considered that this is halitosis anxiety caused by the detection of a slight odor in the oral cavity and the discomfort in the oral cavity.
The conventional oral composition for the purpose of preventing halitosis gives a certain degree of halitosis prevention feeling (a feeling of effect that the halitosis is suppressed or prevented) during or immediately after use in the oral cavity, but the halitosis is felt. It is hard to say that the sense of prevention is sufficient.

In Patent Document 1 (Japanese Patent Laid-Open No. 2003-231621), a polyphosphate and a hydrogen carbonate are used in combination with a water-soluble copper compound, and in Patent Document 2 (Japanese Patent Laid-Open No. 10-212220), it is not a bactericidal agent. By using an ionic surfactant and / or an amphoteric surfactant in combination with an alkali metal bicarbonate and / or carbonate, the sustainability of the oral odor prevention effect of the oral composition is improved, but the oral odor is suppressed. The feeling is unknown.

On the other hand, sodium hydrogen carbonate, which is a hydrogen carbonate, has a peculiar dislike, but gives a refreshing feeling in the oral cavity. We have proposed an oral composition that suppresses mucosal irritation and maintains a refreshing feeling in the oral cavity by using an activator in combination. Furthermore, the so-called baking soda dentifrice containing sodium hydrogen carbonate as an abrasive also has a certain effect of refreshing the oral cavity, but the feeling of suppressing bad breath by sodium hydrogen carbonate is not always sufficient, and the amount of the mixture is not sufficient. In some cases, it is not suitable for hypoallergenic preparations, which have been in increasing demand in recent years.

Japanese Patent Application Laid-Open No. 2003-231621 Japanese Unexamined Patent Publication No. 10-212220 Japanese Unexamined Patent Publication No. 11-49654 Japanese Unexamined Patent Publication No. 2014-125440 Japanese Unexamined Patent Publication No. 2015-182983 Japanese Unexamined Patent Publication No. 2016-102076 Special Table 2014-507440 Gazette Special Table 2012-508741 Special Table 2011-520925

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition which gives a high feeling of cleaning the oral cavity and an excellent feeling of preventing halitosis, has a good feeling of use, and is suitable for preventing bad breath.

As a result of diligent studies to achieve the above object, the present inventors have added an anionic surfactant and a specific nonionic surfactant to one or more selected from hydrogen carbonate and a chelating agent, and a specific N. When combined with -substitution-p-mentan-carboxamide, it gives a high oral cleaning feeling and an excellent bad breath prevention feeling in the oral composition, especially the dentifrice composition, and has a good feeling of use and is effective in preventing bad breath. It was found that it could be used, and the present invention was made.
That is, in the present invention, one or more selected from (A) hydrogen carbonate (A-1) and chelating agent (A-2), (B) anionic surfactant, and (C) poly in the dentifrice composition. A specific amount of one or more nonionic surfactants selected from oxyethylene hydrogenated toothpaste oil, polyoxyethylene alkyl ether and polyglycerin fatty acid ester is blended in a specific amount, and (D) N- (4-cyanomethylphenyl) -2. By blending -isopropyl-5-methylcyclohexanecarboxamide in a relatively small amount, these components interact specifically, which improves the effect of cleaning the oral cavity and the effect of preventing mouth odor, and also gives a feeling of irritation. Is also suppressed. Therefore, according to the present invention, it is possible to suppress the irritation sensation after application to the oral cavity and impart a high oral cleaning sensation and an excellent halitosis prevention sensation, thereby reducing a slight odor in the oral cavity and discomfort in the oral cavity. It is also possible to suppress the anxiety of bad breath caused by it.
Although the mechanism of action in the present invention is unknown, it is presumed that the action on the oral mucosa, the stain removing action, the cooling action, and the like are involved in a complex manner.

In the present invention, as shown in Examples described later, the combination of the components (A), (B), (C) and (D) is specific and exceptional, which cannot be achieved if any of the components is lacking. It has a good effect. As shown in the comparative example described later, if the component (A) is not blended, the feeling of cleaning the oral cavity and the feeling of preventing bad breath are inferior even if the component (D) is blended together with the components (B) and (C) ( Comparative Example 1) Further, even if the amount of the component (B) is increased, a sufficient feeling of cleaning the oral cavity cannot be obtained and the feeling of irritation becomes stronger (Comparative Example 4). When the component (D) was not blended, even if the components (B) and (C) were blended together with the component (A), the feeling of cleaning the oral cavity and the feeling of preventing bad breath were inferior (Comparative Examples 7 and 9). If the component (B) or (C) is not blended, or if the amount of the component (B) or (C) is too small, the oral cavity is blended even if the components (A) and (B) are blended. The feeling of cleaning the inside and the feeling of preventing bad breath were inferior, the feeling of irritation became stronger, and the effect of the present invention was inferior (Comparative Examples 3 to 6).

It should be noted that, as described in Patent Documents 1 and 2, even if a disinfectant or a water-soluble copper compound is not used for the prevention or suppression of halitosis, the present invention can provide an excellent feeling of cleaning the oral cavity and a feeling of preventing bad breath. .. Further, Patent Documents 4 to 9 (Japanese Patent Laid-Open Nos. 2014-125440, 2015-182983, 2016-102076; Japanese Patent Laid-Open Nos. 2014-507440, 2012-508741, 2011-520925) can be found. Disclosed are oral compositions containing N-substituted-p-menthane-carboxamide, which are cooling or improving the refreshing and refreshing sensation of the refreshing agent N-substituted-p-mentane-carboxamide. On the other hand, the present invention is to improve the feeling of cleaning the oral cavity and the feeling of preventing bad breath by combining the component (D) and the component (D) with the components (A), (B) and (C).

Therefore, the present invention provides the following dentifrice composition.
[1]
(A) One or more selected from bicarbonate (A-1) and chelating agent (A-2) 0.1 to 10% by mass,
(B) Anionic surfactant 1 to 3% by mass,
(C) One or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether and polyglycerin fatty acid ester 0.1 to 1% by mass,
And (D) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide 0.00001-0.01% by mass
A dentifrice composition containing.
[2]
The dentifrice composition according to [1], wherein the chelating agent (A-2) is selected from condensed phosphate and fruit acid.
[3]
The dentin composition according to [2], wherein the condensed phosphate is selected from sodium pyrophosphate, sodium polyphosphate and sodium hexametaphosphate.
[4]
The dentifrice composition according to [2], wherein the fruit acid is selected from malic acid, citric acid and tartaric acid.
[5]
The component (A) is a hydrogen carbonate (A-1) and a chelating agent (A-2), and the content of the component (A-1) is 0.1 to 5% by mass, that of the component (A-2). Described in any of [1] to [4], wherein the content is 0.1 to 5% by mass, and the total content of the components (A-1) and (A-2) is 0.2 to 10% by mass. Toothpaste composition.
[6]
The dentifrice composition according to any one of [1] to [5], which further contains 8 to 70% by mass of an abrasive.

According to the present invention, it is possible to provide a dentifrice composition suitable for halitosis prevention, which gives a high oral cleansing sensation and an excellent halitosis prevention sensation, suppresses irritation and has a good usability. The dentifrice composition of the present invention can also be expected to be used as a halitosis preventive preparation for eliminating the anxiety of halitosis of users who are sensitive to odors, which has been increasing in recent years.

Hereinafter, the present invention will be described in more detail. The dentin composition of the present invention comprises one or more selected from (A) hydrogen carbonate (A-1) and chelating agent (A-2), (B) anionic surfactant, and (C) polyoxyethylene. One or more nonionic surfactants selected from cured castor oil, polyoxyethylene alkyl ethers and polyglycerin fatty acid esters, and (D) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide. Contains.

The component (A) is a bicarbonate (A-1) or a chelating agent (A-2), and may be a bicarbonate (A-1) or a chelating agent (A-2), but in terms of exhibiting the effect. , Bicarbonate (A-1) and chelating agent (A-2) can also be used.

As the hydrogen carbonate (A-1), sodium hydrogen carbonate can be used.
The blending amount of the hydrogen carbonate (A-1) is preferably 0.1 to 10% (mass%, the same applies hereinafter) of the entire composition, and more preferably 0.3 to 5%.

As the chelating agent (A-2), condensed phosphate or fruit acid can be used, but condensed phosphate is particularly preferable.
Examples of the condensed phosphate include pyrophosphate, polyphosphate, hexametaphosphate and the like, and examples of the salt include alkali metal salts such as sodium salt. Among them, pyrophosphate, polyphosphate, hexamethaphosphate, particularly pyrophosphate and polyphosphate are preferable in terms of the feeling of cleaning and the feeling of preventing bad odor. In particular, sodium polyphosphate, which is a polyphosphate, is more preferable in terms of the actual feeling of preventing bad breath.
Examples of the fruit acid include malic acid, citric acid, tartaric acid and the like. Among them, malic acid and citric acid, particularly citric acid, are preferable in terms of the actual feeling of preventing bad breath.
The blending amount of the chelating agent (A-2) is preferably 0.1 to 5%, more preferably 0.5 to 3% of the total composition.

The blending amount of the component (A) (components (A-1) and (A-2)) is 0.1 to 10%, preferably 0.2 to 10%, and more preferably 0. It is 2 to 5%. If it is less than 0.1%, the feeling of cleaning and the feeling of preventing bad breath are inferior. If it exceeds 10%, the feeling of irritation becomes stronger.
Further, when the component (A) is a bicarbonate (A-1) and a chelating agent (A-2), the blending amount of the component (A-1) is preferably 0.1 to 5%, (A). -2) The blending amount of the component is preferably 0.1 to 5%.

(B) Examples of the anionic surfactant include alkyl sulfates such as lauryl sulfate and myristyl sulfate, α-olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, and N-methyl-N. -N-acyl taurine salt such as acyl taurine salt, acyl sarcosine salt such as lauroyl sarcosin salt, and acyl amino acid salt such as N-acyl-L-glutamate. Examples of the salt include alkali metal salts such as sodium salts. Of these, sodium lauryl sulfate as an alkyl sulfate, sodium α-olefin sulfonate as an α-olefin sulfonate, sodium lauroyl sulcosine as an acyl sarcosin salt, and particularly sodium lauryl sulfate are preferable in terms of suppressing irritation.

The blending amount of the (B) anionic surfactant is 1 to 3%, preferably 1.4 to 2.5%, and more preferably 1.4 to 2.0% of the entire composition. If it is less than 1%, the feeling of cleaning and the feeling of preventing bad breath are inferior. If it exceeds 3%, the feeling of irritation becomes stronger.

The component (C) is one or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether and polyglycerin fatty acid ester. Of these, polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether, particularly polyoxyethylene hydrogenated castor oil, are preferable in terms of preventing bad breath and suppressing irritation.
The average number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil (hereinafter abbreviated as EO) is preferably 10 to 60 mol.
E. of polyoxyethylene alkyl ethers. O. Is preferably 2 to 25 mol, and the alkyl group preferably has 12 to 18 carbon atoms.
The polyglycerin fatty acid ester preferably has 12 to 18 carbon atoms in the fatty acid.

The blending amount of the component (C) is 0.1 to 1%, preferably 0.3 to 1%, and particularly preferably 0.3 to 0.8% of the entire composition. If it is less than 0.1%, the feeling of cleaning is inferior. If it exceeds 1%, the feeling of preventing bad breath is lowered, and the feeling of cleaning may be lowered.

In the present invention, a nonionic surfactant other than the component (C) may be further blended as long as the effect of the present invention is not impaired.
Examples of the nonionic surfactant other than the component (C) include polyoxyethylene fatty acid ester; sucrose fatty acid ester such as maltose fatty acid ester; sugar alcohol fatty acid ester such as martitol fatty acid ester and lactitol fatty acid ester; Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate; fatty acid diethanolamides such as lauric acid mono or diethanolamide; sorbitan fatty acid esters; polyoxyethylene polyoxypropylene copolymers; polyoxyethylene polyoxypropylene fatty acid esters Can be mentioned.
When a nonionic surfactant other than the component (C) is blended, the blending amount thereof is preferably 3% or less, particularly 1% or less, and may be 0% without blending.

(D) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide has an effect of improving the feeling of cleaning and the feeling of preventing bad breath. When N-substituted-p-menthane-carboxamide other than the component (D) is used instead of the component (D), the feeling of cleaning and the feeling of preventing bad breath according to the present invention cannot be obtained, and the action and effect are not obtained. Inferior.
The blending amount of the component (D) is 0.00001 to 0.01%, preferably 0.00005 to 0.005% of the entire composition. If it is less than 0.00001%, the feeling of cleaning and the feeling of preventing bad breath are inferior. If it exceeds 0.01%, the feeling of irritation becomes stronger.

In the present invention, a known fragrance can be blended. For example, menthol, anator, carboxylic, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalol, ethyllinalol, crocodile, timole, sparemint oil, peppermint oil, sage oil, rosemary oil, Examples thereof include katsura oil, pimento oil, katsura leaf oil, perilla oil, winter green oil, choji oil, and eucalyptus oil. The blending amount of these fragrances is a normal amount as long as the effect of the present invention is not impaired.

The dentifrice composition of the present invention can be in the form of a paste, a liquid such as a liquid, or various other dosage forms such as dentifrice, liquid dentifrice, liquid dentifrice, and dentifrice. Can be prepared by the method. Further, in addition to the above-mentioned components, other known components usually used in the dentifrice composition can be added as needed within a range that does not impair the effects of the present invention. Optional ingredients that can be blended include abrasives, binders, wetting agents, surfactants other than anionic surfactants and nonionic surfactants, sweeteners, preservatives, pH adjusters, medicinal ingredients and the like. Be done.

As the polishing agent, calcium phosphate-based compounds such as dibasic calcium phosphate / dihydrate salt or anhydrous salt, primary calcium phosphate, tertiary calcium phosphate, calcium pyrophosphate, etc .; precipitate silica, aluminosilicate, zirconosilicate, titanium-binding silica, etc. Calcium-based abrasives; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, magnesium tertiary phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, and one or two of these. Can contain more than seeds. Among these, silica-based abrasives and calcium carbonate-based abrasives containing silicates as main components such as precipitate silica, aluminosilicate, zirconosilicate, and titanium-binding silica, and silica-based abrasives such as precipitate silica are particularly present. Abrasives are preferred.

Abrasives, particularly sedimentary silica, are preferably abrasive particles having a particle size of 1 to 40 μm and a BET specific surface area of 80 to 250 square meters per gram. The particle size is a measured value by a particle size distribution measuring device (Microtrak particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium; water).
Commercially available products can be used as such silica-based abrasives, and for example, HUBER's ZEODENT 124, ZEODENT 113, Rhodia's TIXOSIL 73, TIXOSIL 63, Degussa's Side 3, Siden 20, and Taki Chemical Co., Ltd. Examples include zirconosilicate and aluminosilicate manufactured by Co., Ltd.
The blending amount of the abrasive is preferably 8 to 70%, particularly preferably 10 to 50% of the entire composition.

Further, the abrasive may be in the form of granules, and granules can be blended as a component having abrasiveness. The granules are particles obtained by forming water-insoluble powder into granules, and granules using a binder may be used for granulation.

As the binder, xanthan gum, sodium carboxymethyl cellulose, sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, carrageenan, methyl cellulose, hydroxyethyl cellulose sodium, tragant gum, karaya gum, arabiya gum, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbopol , Organic binders such as bee gum and propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate can be blended. These can be used in one type or two or more types. In the case of an organic binder, the blending amount of these binders is preferably 0.8 to 5%, particularly 1 to 3% of the entire composition, and in the case of an inorganic binder, 0.5 to 0.5% of the entire composition. 10%, particularly 1-8% is preferable.

Examples of the wetting agent include sugar alcohols such as sorbitol and xylit, and polyhydric alcohols such as propylene glycol and glycerin. The blending amount is usually 5 to 50%, particularly 20 to 45% of the total composition.

As the surfactant, an amphoteric surfactant may be blended. Specific examples thereof include fatty acid amide propyl betaine such as cocamidopropyl betaine; alkyl betaine such as lauryldimethylaminoacetic acid betaine; and imidazoline type amphoteric surfactant such as coconut oil fatty acid imidazolium betaine.

Examples of the sweetening agent include saccharin sodium, stebioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perraltin, glycyrrhizin, thaumatin, aspalathylphenylalanine methyl ester and the like.
Examples of the preservative include paraoxybenzoic acid ester, benzoic acid or a salt thereof and the like.

Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate and sodium dihydrogen phosphate.

Fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate; enzymes such as dextranase, amylase, protease and mutanase; tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, glycyrrhetinate and the like. Anti-inflammatory agents; cell activators such as sodium chloride, vitamins, alanine, etc .; bactericides such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokithiol, lysoteam chloride; water-soluble such as copper chlorophyll, copper gluconate, etc. Sexual copper compounds; dentin preventive agents such as zeolite; blood circulation promoters such as vitamin E; amino acids such as alanine, glycine and proline. The blending amount of the medicinal ingredient can be an effective amount within a range that does not interfere with the effect of the present invention.

Further, as optional components, inorganic compounds such as mica titanium, titanium oxide and bentonite; cellulosic organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch and glucomannan; vinyl acetate and acrylic resin. , Polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder and other synthetic polymer compounds or their copolymers; carnauba wax, rosin, rice wax, microcrystallin wax, honey wax, paraffin wax and other waxes; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended within a range that does not interfere with the effects of the present invention.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
The dentifrice compositions having the compositions shown in Tables 1 to 4 were prepared by a conventional method. The obtained dentifrice composition was used as a sample and evaluated by the following method. The results are also shown in the table.

<Evaluation method>
The feeling of use of the dentifrice composition was evaluated by four subject panelists. 1 g of a sample dentifrice composition was placed on a toothbrush (Clinica Advantage Toothbrush, 4-row compact normal type, manufactured by Lion Corporation), and the teeth were brushed for 3 minutes.
After rinsing (after rinsing the oral cavity with water after brushing the teeth), the feeling of cleaning the oral cavity, the feeling of preventing bad breath, and the feeling of irritation during brushing were judged according to the following scoring criteria. The average of the scores of the four people was calculated and evaluated according to the following evaluation criteria.
Here, the actual feeling of cleaning the oral cavity is a sensation that the oral cavity is cleaned and cleaned. The actual feeling of prevention of bad breath means that the slight odor in the oral cavity and the discomfort in the oral cavity are not felt.

(1) Oral cleaning after rinsing Actual score criteria 1: I didn't feel 2: I can't say either 3: I felt a little 4: I felt 5: I felt very much Evaluation criteria ◎: The average score of 4 people was 4 points Or more ○: The average score of 4 people is 3 points or more and less than 4 points △: The average score of 4 people is 2 points or more and less than 3 points ×: The average score of 4 people is less than 2 points

(2) Halitosis prevention actual feeling score criteria 1: I did not feel 2: I can not say either 3: I felt a little 4: I felt 5: I felt very much Evaluation criteria ◎: The average score of 4 people is 4 points or more ○: 4 The average score of 4 people is 3 points or more and less than 4 points △: The average score of 4 people is 2 points or more and less than 3 points ×: The average score of 4 people is less than 2 points

(3) Stimulation feeling while brushing teeth Rating criteria 1: Strong stimulus 2: Stimulation 3: Slight stimulus but no problem Level 4: Almost no stimulus 5: No stimulus Evaluation criteria ◎: 4 people The average score of 4 people is 4 points or more ○: The average score of 4 people is 3 points or more and less than 4 points △: The average score of 4 people is 2 points or more and less than 3 points ×: The average score of 4 people is less than 2 points

Details of the raw materials used are shown below.
(A) ((A-1))
Sodium hydrogen carbonate: Sodium bicarbonate (manufactured by Asahi Glass Co., Ltd.)
(A) ((A-2))
Sodium polyphosphate: Sodium polyphosphate (manufactured by Taihei Kagaku Sangyo Co., Ltd.)
Sodium pyrophosphate: Sodium pyrophosphate (manufactured by Taihei Kagaku Sangyo Co., Ltd.)
Sodium hexametaphosphate: Sodium hexametaphosphate (manufactured by Taihei Chemical Industry Co., Ltd.)
Malic acid: Malic acid (manufactured by Fuso Chemical Industry Co., Ltd.)
Citric acid: Citric acid (manufactured by Fuso Chemical Industry Co., Ltd.)
(B)
Sodium lauryl sulfate: Texaspon (manufactured by BASF)
Sodium α-olefin sulfonate:
K Liporan PJ-400CJ (manufactured by Lion Specialty Chemicals Co., Ltd.)
Lauroyl sarcosine sodium: Soipon SLP (manufactured by Kawaken Fine Chemical Co., Ltd.)
(C)
Polyoxyethylene (20) hardened castor oil:
NIKKOL HCO-20 (manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added 20)
Polyoxyethylene (5) stearyl ether:
EMALEX605 (manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added 5)
(D)
N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide: Evacool 180 (manufactured by Givaudan Japan Co., Ltd.)

Claims (5)

(A) Bicarbonate (A-1) and / or chelating agent (A-2 ) 0.1 to 10% by mass,
(B) Anionic surfactant 1 to 3% by mass,
(C) One or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether and polyglycerin fatty acid ester.
0.1 to 1% by mass
and
(D) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide 0.00001 to 0.01% by mass
A dentifrice composition in which the chelating agent (A-2) is selected from condensed phosphate and fruit acid .
Toothpaste composition. The dentin composition according to claim 1 , wherein the condensed phosphate is selected from sodium pyrophosphate, sodium polyphosphate and sodium hexametaphosphate. The dentifrice composition according to claim 1 or 2, wherein the fruit acid is selected from malic acid, citric acid and tartaric acid. The component (A) is a chelating agent (A-2) selected from hydrogen carbonate (A-1) and condensed phosphate and fruit acid , and the content of the component (A-1) is 0.1 to 5. Claimed that the content of the component (A-2) is 0.1 to 5% by mass, and the total content of the components (A-1) and (A-2) is 0.2 to 10% by mass. The dentin composition according to any one of 1 to 3 . The dentifrice composition according to any one of claims 1 to 4 , further comprising an abrasive in an amount of 8 to 70% by mass.