JP2003231621A - Composition for oral cavity for preventing foul breath - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a composition for oral cavity for preventing foul breath, sustaining the foul breath-preventing effects for a long time and having good sense of use. <P>SOLUTION: This composition for the oral cavity for preventing the foul breath is obtained by formulating a water-soluble copper compound, one or more kinds of linear or cyclic polyphosphoric acid salts represented by the formula (1): M<SB>n+2</SB>P<SB>n</SB>O<SB>3n-1</SB>(1), or the formula (2): (MPO<SB>3</SB>)<SB>m</SB>(2) (wherein, n≥2; m≥3; and M is a monovalent metal with the proviso that a part of M may be substituted with hydrogen atom), and 0.01-1 wt.% hydrogen carbonate based on the whole composition. <P>COPYRIGHT: (C)2003,JPO

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition for preventing bad breath, which has a long-lasting effect and a good feeling upon use. 2. Description of the Related Art
It is known that water-soluble copper compounds such as copper gluconate and copper citrate have an antibacterial effect, an effect of removing bad breath, and an effect of inhibiting plaque formation, and various dentifrice compositions containing these copper compounds have been proposed. (U.S. Pat. Nos. 3,044,939, 3,565,933, 3,655,868, and 411)
No. 2066, JP-A-56-169519 and JP-A-56-1
No. 69620, No. 61-143317, No. 62-14
2109, JP-A-1-153620, 1-1
No. 53622). [0003] However, oral compositions containing the above copper compound have the disadvantage that the effect of removing bad breath is reduced in a short time, and it is desired to develop a composition for oral cavity that maintains the effect of removing bad breath for a long time. Had been rare. [0004] The present invention has been made in view of the above circumstances,
An object of the present invention is to provide an oral composition for preventing bad breath, which has a long-lasting effect of preventing bad breath and has a good feeling of use. Means for Solving the Problems and Embodiments of the Invention The present inventors have made intensive studies to achieve the above object, and as a result, have found that a water-soluble copper compound and the following general formula (1) or ( One or more linear or cyclic polyphosphates represented by 2) and a hydrogen carbonate are used in combination, and in this case, the hydrogen carbonate is used in an amount of 0.01 to 1% (mass) of the whole composition. (Percentage, the same applies hereinafter)), it has been found that an oral composition for preventing bad breath can be obtained, which has a long-lasting effect on breathing for a long time and a good feeling upon use. Incidentally, a technique of blending sodium bicarbonate into an oral composition (JP-A-52-54038, JP-A-59-54038).
176206), a technique of blending sodium bicarbonate to give a refreshing feeling in the mouth (Japanese Patent Laid-Open No. 49-698)
No. 49) is publicly known. Further, a technique for removing tongue coating by blending bicarbonate under specific conditions in an oral composition (Japanese Patent Application Laid-Open No. 2000-2000)
No. 297021, JP-A-2000-022800),
A technique of blending a condensed phosphoric acid compound as a tongue coating remover is also known (Japanese Patent Application Laid-Open No. 10-182587). However, in the above-mentioned technology for chemically removing tongue coating, when bicarbonate is added, if the effect of removing tongue coating is sufficiently imparted, the amount of hydrogencarbonate added increases, and the salty taste peculiar to hydrogencarbonate is strongly used. Has the disadvantage that it becomes worse. When a condensed phosphoric acid compound is blended, a sufficient effect cannot be obtained by blending the condensed phosphoric acid compound alone, so that it is used in combination with alkyldiaminoethyl glycine hydrochloride (Japanese Patent Laid-Open No. 11-2092).
No. 57) has been proposed, but this method has problems such as strong bitterness and oily odor. [0008] Further, a technique of blending copper gluconate or copper citrate and a polyphosphate in a dentifrice composition is disclosed in Japanese Patent No. 25.
No. 80657. However, a water-soluble copper compound, one or more linear or cyclic polyphosphates represented by the following general formula (1) or (2), and 0.01% of the total composition
As will be apparent from the examples described later, the copper retention in the oral cavity is unexpectedly improved and the effect of removing bad breath is maintained for a long time, as apparent from the examples described later. It is a new finding of the present inventor that a composition for oral cavity which has good usability and is useful for preventing bad breath can be obtained. Accordingly, the present invention provides a water-soluble copper compound and the following general formula (1) or (2): M _{n + 2} P _n O _3n-1 (1) (MPO ₃ ) _m (2) In the formula, n ≧ 2 and m ≧ 3, and M represents a monovalent metal, but a part of M may be substituted with a hydrogen atom.) Provided is an oral composition for preventing bad breath, which comprises one or more kinds thereof and 0.01 to 1% of a bicarbonate of the whole composition. Hereinafter, the present invention will be described in more detail. Examples of the water-soluble copper compound to be incorporated in the oral composition of the present invention include copper gluconate, copper citrate, copper lauroyl sarcosinate, copper formate, copper acetate, and the like. Copper propionate, copper butyrate, copper lactate, copper oxalate, copper phytate, copper tartrate, copper malate, copper succinate, copper malonate, copper maleate, copper benzoate, copper salicylate, copper aspartate, copper glutamate , Copper organic salts such as copper fumarate, copper glycerophosphate, sodium copper chlorophyllin, and inorganic acid copper salts such as copper chloride, copper fluoride, copper sulfate, copper fluorosilicate, copper nitrate, copper fluoroborate, copper iodate, etc. And organic copper salts, especially copper gluconate, are preferably used. The compounding amount of the water-soluble copper compound is 0.0001 to 5%, preferably 0.001 to 2%, more preferably 0.05 to 1% of the whole composition. As the condensed phosphate, a linear or cyclic one represented by the following general formula (1) or (2) is used.
In the present invention, by the chelating action of this condensed phosphate,
Improves the stability of copper ions in the formulation and exerts an excellent effect of preventing and maintaining bad breath. M _{n + 2} P _n O _3n-1 (1) (MPO ₃ ) _m (2) In the above formula, n ≧ 2, m ≧ 3, preferably 30 ≧ n ≧ 2.
30 ≧ m ≧ 3, and M is 1 such as sodium, potassium, etc.
Although a valent metal is shown, a part of M may be replaced with a hydrogen atom. As the condensed phosphates of the above formulas (1) and (2), sodium pyrophosphate and sodium polyphosphate are particularly preferred. The amount of the condensed phosphate is preferably 0.1 to 10%, more preferably 1 to 6% of the whole composition. In the present invention, a water-soluble salt such as sodium bicarbonate is used as the bicarbonate, and the amount of the bicarbonate is 0.01 to 1% of the total composition, preferably 0.2 to 2%.
0.5%. Further, in the present invention, the hydrogen carbonate and the condensed phosphate are mixed at a mixing ratio (mass ratio) of hydrogen carbonate / condensed phosphate of 1/10 to 1/2, particularly 1/5 to 1/2. 1/2,
In particular, it is preferable to mix in a range of 1/5 to 2/5. By mixing in such a range of the mixing ratio, the copper retention property in the oral cavity is improved, so that the effect of removing bad breath is maintained for a long time. Thus, it is possible to obtain an oral composition having a good feeling in use. If the blending ratio of the condensed phosphate is too large and the blending ratio is less than the above ratio, the taste of the composition may be deteriorated,
If the compounding ratio of the bicarbonate is too large and the mixing ratio exceeds the above ratio, the effect of preventing bad breath may not be maintained for a long time. The oral composition according to the present invention comprises a toothpaste,
It can be prepared into dentifrices such as liquid dentifrice, mouth washes, mouthwash, oral pasta and the like. In this case, as the other components, appropriate components usually used can be blended. For example, in the case of dentifrice, an abrasive, a binder, a thickener, a surfactant,
Sweetening agents, flavors, preservatives, various active ingredients, and the like can be added. In this case, as the polishing agent, calcium hydrogen phosphate / anhydride, calcium hydrogen phosphate / dihydrate, tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, silicic anhydride, silicic acid One or more of aluminum, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, polymethyl methacrylate, and other synthetic resins may be blended. Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose and hydroxyethylcellulose; alginic acid derivatives such as sodium alginate and propylene glycol alginate; gums such as xanthan gum, gellan gum, tragacanth gum and karaya gum; One or more kinds of synthetic binders such as polyvinyl alcohol, sodium polyacrylate, and carboxyvinyl polymer, and inorganic binders such as silica gel, veegum, and laponite may be blended. As humectants, glycerin, sorbitol, propylene glycol, polyethylene glycol,
One or more polyhydric alcohols such as xylitol, maltitol and lactitol may be blended. As the surfactant, an anionic surfactant, a nonionic surfactant and an amphoteric surfactant are used. Examples of the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, and sodium N-lauroyl sarcosinate and sodium N-myristoyl sarcosinate.
N-acyl glutamates such as sodium acyl sarcosinate, sodium dodecyl benzene sulfonate, hydrogenated coconut fatty acid, sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, Sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate and the like are used. Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan monolau. Rate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, lauric acid mono- or diethanolamide, fatty acid mono- or myristic acid mono- or diethanolamide or the like. Diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxy Etc. Ji Ren polyoxypropylene fatty acid ester is used. As the fragrance component, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, cineol, linalool, ethyl linalool, crocodile, thymol, peppermint oil, spearmint oil, wintergreen oil, Flavors such as clove oil and eucalyptus oil may be used alone or in combination. As a sweetener, sodium saccharin,
Sweetening agents such as stevioside, dipotassium glycyrrhizinate, perillartin, thaumatin and the like can be added. The active ingredients include fluorides such as sodium fluoride and sodium monofluorophosphate, enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, tranexamic acid, epsilon aminocaproic acid, dipotassium glycyrrhizinate. , Glycyrrhetinic acid, bisabolol, chlorophyll, sodium chloride, water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride, benzalkonium chloride,
One or more active ingredients such as benzethonium chloride may be blended. The amounts of these optional components can be set to ordinary amounts as long as the effects of the present invention are not impaired. The oral composition of the present invention has a long-lasting effect of preventing bad breath for a long time, has a good feeling in use, and is useful for preventing bad breath. EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, in the following examples, the blending percentage is a mass percentage. [Comparative Examples 1 to 9, Examples 1 and 2] Oral compositions for preventing bad breath having the following compositions were prepared by a conventional method, and the usability and copper retention were evaluated by the following methods, and comprehensively evaluated. Table 1 shows the results. Comparative Example 1: Liquid dentifrice Copper gluconate 0.1% Sodium bicarbonate 5 Fragrance 1 Propylene glycol 3 85% Glycerin 25 Xanthan gum 0.2 Sodium polyacrylate 0.2 Abrasive silica 10 Sodium lauryl sulfate 1.5 saccharin sodium 0.2 purified water balance total 100% [0034] Comparative example 2: mouthwash gluconate 0.2% glycerin 20 ethyl alcohol 15 polyoxyethylene hardened castor oil 2 sodium bicarbonate 1 sodium fluoride 0.1 perfume 1 Purified water balance 100% Comparative Example 3: Toothpaste Copper gluconate 0.5% Potassium hydrogen carbonate 10 Flavor 1 Propylene glycol 3 85% Glycerin 25 Xanthan gum 0.7 Sodium polyacrylate 0.7 Abrasive silica 20 Lauryl sulfur Sodium 1.5 Sodium saccharin 0.2 Purified water balance Total 100% [0036] Comparative Example 4: toothpaste gluconate 0.3% sodium hydrogen carbonate 1 Perfume 1 Propylene glycol 2.5 70% sorbitol 25 carboxymethylcellulose 1.2 Aluminum hydroxide 18 Sodium lauryl sulfate 1.3 Saccharin sodium 0.15 Purified water Balance 100% [Comparative Example 5] Toothpaste copper gluconate 0.1% Sodium pyrophosphate 5 Fragrance 1 Polyethylene glycol 2.5 70% Sorbit 20 carrageenan 1.0 xanthan gum 0.2 calcium 25 sodium lauryl sulfate carbonate 1.3 sodium saccharin 0.2 purified water balance total 100% [0038] Comparative example 6: toothpaste gluconate 6% sodium bicarbonate 3 Tolypocladium Sodium 6 Perfume 1 Propylene glycol 2.5 70% sorbitol 25 carboxymethylcellulose 1.2 Sodium phosphate dibasic calcium 18 lauryl sulfate 1.3 Sodium saccharin 0.15 Purified water balance Total 100% phosphoric acid [0039] Comparative Example 7: toothpaste Copper gluconate 0.1% Sodium bicarbonate 5 Sodium hexametaphosphate 5 Fragrance 1 Propylene glycol 2.5 85% Glycerin 25 Carrageenan 1.2 Silicic anhydride 18 Sodium lauryl sulfate 1.3 Sodium saccharin 0.15 Purified water Balance 100% Comparative Example 8: Toothpaste Copper gluconate 0.1% Potassium bicarbonate 0.5 Sodium trimetaphosphate 0.5 Fragrance 0.8 Propylene glycol 3 85% Glycerin 25 Carboxymethylcellulose 1.5 Calcium carbonate 20 Sodium lauryl sulfate 1.3 Saccharin sodium 0.1 Purified water Balance 100% Comparative example 9: Toothpaste Sodium bicarbonate 0.6% Sodium tripolyphosphate 3 Fragrance 1 Propylene glycol 3 85% Glycerin 30 Xanthan gum 0.8 Carboxymethylcellulose 0.3 Abrasive silica 15 Sodium lauryl sulfate 1.2 Saccharin sodium 0.1 Purified water balance 100% Example 1: Toothpaste Copper gluconate 0.1% Sodium bicarbonate 0 .6 Sodium tripolyphosphate 3 Fragrance 1 Propylene glycol 3 85% glycerin 30 Xanthan gum 0.8 Carboxymethyl cellulose 0.3 Abrasive silica 15 Sodium lauryl sulfate 1.2 Saccharin sodium 0. 1 Purified water balance 100% Example 2: Toothpaste Copper gluconate 0.2% Sodium bicarbonate 0.6 Sodium pyrophosphate 2 Fragrance 1 Propylene glycol 3 70% Sorvite 30 Carrageenan 0.4 Carboxymethylcellulose 0. 2 Abrasive silica 20 Sodium lauryl sulfate 1.8 Saccharin sodium 0.05 Purified water Residual 100% Copper retention evaluation method: Brushing or mouth washing was performed for about 3 minutes with about 1 g of dentifrice or 20 ml of mouth washing solution. . After rinsing the mouth with water, 1 hour, 2 hours, and 5 hours later, saliva was collected, and the copper concentration in saliva was measured by atomic absorption to evaluate. Toothpaste feeling: ○: No salty ×: Salty [Table 1] *: Sensory evaluation confirmed that the products of Examples 1 and 2 had no bad breath until 5 hours after use. Next, an oral composition having the following composition was prepared by a conventional method and evaluated in the same manner as described above. As a result, all of the compositions had a high copper retention property, the effect of removing bad breath was maintained for a long time, and the feeling upon use was good. I found it. Example 3 Toothpaste Copper gluconate 0.3% Sodium bicarbonate 0.6 Sodium tripolyphosphate 3 Sodium fluoride 0.21 Fragrance 1 Propylene glycol 3 85% Glycerin 30 Carboxymethyl cellulose 1.2 Abrasive silica 15 Triclosan 0.5 Sodium lauryl sulfate 1.2 Saccharin sodium 0.1 Purified water Balance 100% [Example 4] Toothpaste copper gluconate 0.3% Sodium bicarbonate 0.6 Sodium tripolyphosphate 3 Fluoride Sodium 0.21 Fragrance 1 Propylene glycol 3 85% glycerin 30 Gellan gum 0.3 Carboxymethylcellulose 0.8 Abrasive silica 15 Sodium lauryl sulfate 1.2 Saccharin sodium 0.1 Lauroyl sarcosine sodium 0.2 Purified water balance Total 100% [0049] [Example 5] 0.3% toothpaste gluconate sodium bicarbonate 0.6 Sodium tripolyphosphate 3 Sodium fluoride 0.21 Perfume 1 Propylene glycol 3 70% sorbitol Liquid 30 Carboxymethylcellulose 1.4 Abrasive silica 18 Sodium lauryl sulfate 1.5 Sodium saccharin 0.1 Sodium lauroyl sarcosine 0.2 Purified water Balance 100% [Example 6] Toothpaste Copper gluconate 0.3% sodium bicarbonate 0.6 tripolyphosphate 3 sodium fluoride 0.21 perfume 1 propylene glycol 3 70% sorbitol solution 20 Pluronic 15 abrasive silica 18 sodium saccharin 0.1 sodium lauroyl sarcosinate 0.2 purified water Balance Example 7 Toothpaste Copper Gluconate 0.5% Sodium Bicarbonate 0.3 Sodium Tripolyphosphate 1.0 Sodium Fluoride 0.21 Fragrance 1 Propylene Glycol 3 70% Sorbit Solution 30 Xanthan Gum 0. 6 Sodium alginate 0.5 Abrasive silica 18 Sodium lauryl sulfate 1.5 Sodium saccharin 0.1 Sodium lauroyl sarcosine 0.2 Purified water Balance 100% [Example 8] Toothpaste Copper gluconate 0.5% Carbonic acid Sodium hydrogen 0.3 Sodium tripolyphosphate 1.0 Sodium fluoride 0.21 Fragrance 1 Propylene glycol 3 70% sorbite liquid 30 Xanthan gum 0.6 L-carrageenan 0.5 Abrasive silica 18 Sodium lauryl sulfate 1.5 Saccharinna Potassium 0.1 sodium lauroyl sarcosinate 0.2 Purified water balance Total 100%

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Claims (1)

[Claim 1] A water-soluble copper compound and the following general formula (1) or (2): M _{n + 2} P _n O _3n-1 (1) (MPO ₃ ) _m (2) (however, In the above formula, n ≧ 2, m ≧ 3, and M represents a monovalent metal, but a part of M may be substituted with a hydrogen atom.) An oral composition for preventing bad breath, comprising one or more salts, and 0.01 to 1% by mass of bicarbonate of the whole composition.