JP2011126788A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for the oral cavity, not only having excellent recalcification effects, but also having excellent storage stability of calcium ion and monofluorophosphate ion with time, and providing good sense of use. <P>SOLUTION: The composition for the oral cavity contains (A) 0.1-2.0 mass% of the monofluorophosphate, (B) 0.1-2.0 mass% of calcium glycerophosphate, and (C) 0.1-1.0 mass% of one or more kinds of polymers selected from a polydimethylmethylenepiperidium chloride, and a copolymer of dimethyldiallylammonium chloride, and acrylic acid and/or acrylamide. <P>COPYRIGHT: (C)2011,JPO&amp;INPIT

Description

  The present invention relates to a composition for oral cavity containing a monofluorophosphate which is excellent in the effect of promoting remineralization and has a good feeling in use and storage stability with time.

  Teeth enamel is mainly composed of hydroxyapatite, and in the oral cavity, the elution (decalcification) of phosphate ions and calcium ions and crystallization (remineralization) into calcium phosphate and hydroxyapatite are usually in equilibrium. is there.

Fluoride ions suppress decalcification in an acidic environment, and promote crystallization of calcium ions and phosphate ions, that is, remineralization in a neutral environment, and thus are effective in preventing caries.
In order to prevent dental caries, conventionally, fluorine has been widely used in oral preparations and has a great track record.

  A known technique for improving the effectiveness of a fluorine preparation is, for example, a technique comprising sodium fluoride, a water-soluble calcium salt and a sugar derivative, forming a colloidal fluoride and improving the retention of fluorine (Patent Document 1). (A) a component for oral cavity selected from a surfactant, an abrasive, a binder, and a lower alcohol, (a) sodium fluoride, (b) a water-soluble calcium salt, and (c) a monosaccharide, an oligosaccharide, a polysaccharide An oral composition containing a fluoride colloid (B) produced by a colloidalization promoting substance such as a monohydric alcohol or an ascorbic acid derivative and (C) a phosphoric acid compound has been proposed (Patent Document 2). However, these techniques have a problem in retention of fluoride colloid in the oral cavity, and there is a problem that fluorine is not liberated unless the pH in plaque is lowered.

Furthermore, although it consists of fluoride, tartaric acid, and water-soluble calcium salt and the technique which improves calcium supply is proposed by patent document 3, this technique is pH 7.5-8.5, and is used for oral cavity. There was a problem that the stability of the ester flavor used in the composition was poor.
Patent Documents 4 and 5 contain three components (A) sugar alcohol, particularly xylitol, (B) calcium ion supply compound, and (C) fluoride ion supply compound, and suppress the formation of calcium fluoride precipitates. Techniques for promoting remineralization have been proposed, but these techniques are not yet sufficiently effective in suppressing calcium fluoride precipitation, and the remineralization action has not been sufficiently exhibited.

  A mixed aqueous solution (pH 4.5 to 7.0) of a water-soluble calcium salt, a divalent metal salt other than calcium, a water-soluble phosphate, and fluoride is a one-pack type or two-pack type for remineralization. Patent Document 6 proposes that it is effective as an aqueous product. However, although this product is effective, there is a problem that the usability of the oral composition deteriorates because it contains a divalent metal salt other than calcium and a water-soluble phosphate.

Patent Document 7 includes a calcium ion supply compound, a monofluorophosphate ion supply compound, and an acid selected from lactic acid, malic acid, and tartaric acid, and has a pH of 4 to 6.2. Oral compositions with a high calcium ion residual ratio and good storage stability have been proposed. Patent Document 8 proposes a multi-composition system composed of a first composition containing a calcium ion supply compound and a second composition containing a fluorine ion supply compound, and malate ion supply compound, monofluorophosphoric acid. An oral composition has been proposed in which calcium fluoride is efficiently adsorbed on teeth by combining with an ion supply compound. However, these techniques are not sufficient for remineralization.
In any of the techniques of Patent Documents 1 to 8, the remineralization promoting action is not sufficient, and there is a problem in the feeling of use of the oral composition.

Japanese Patent Laid-Open No. 03-72415 Japanese Patent Laid-Open No. 06-298631 Japanese Patent Publication No. 08-32619 JP 11-49653 A JP-A-11-106322 Japanese National Patent Publication No. 10-511104 JP 2005-206592 A JP 2006-69990 A

As seen in the above-mentioned known literature, fluoride is important for caries prevention, but from the viewpoint of promoting remineralization that most of the enamel is composed of hydroxyapatite. In addition, it is also important to provide a comfortable feeling for the user, but it is difficult to satisfy all of them with the prior art.
Therefore, the development of a new technique that has an excellent remineralization effect, is excellent in the storage stability of calcium ions and monofluorophosphate ions with time, and has a good feeling in use is strongly developed. It is desired.

  The present invention has been made in view of the above circumstances, and provides an oral composition having an excellent remineralization promoting effect, excellent storage stability of calcium ions and monofluorophosphate ions over time, and good usability. With the goal.

  As a result of intensive studies to achieve the above-mentioned object, the present inventors have achieved excellent reproducibility by combining (A) monofluorophosphate, (B) calcium glycerophosphate and (C) a specific polymer. Combined with calcification promoting effect and excellent storage stability of calcium ion and monofluorophosphate ion over time, it can satisfactorily promote tooth remineralization, effectively reduce or prevent dental caries, and feel The present invention has been found to be satisfactory.

  Patent Documents 7 and 8 describe that the stable supply of calcium ions and the adsorption of calcium fluoride on teeth are improved by the combined use of a monofluorophosphate ion supply compound, a calcium ion supply compound, and a specific organic acid. ing. In addition, calcium glycerophosphate is decomposed by the phosphatase enzyme in plaque, increasing the calcium and phosphate concentration in plaque to promote remineralization, and preventing a significant decrease in plaque pH. Patent Document 6 describes that it is thought to interfere with the metabolism of mutans. However, from the techniques described in these documents, the technical idea and the effects obtained by appropriately using the components (A) to (C) according to the present invention cannot be predicted.

  In contrast, in the present invention, (A) monofluorophosphate, (B) calcium glycerophosphate, (C) polydimethylmethylenepiperidinium chloride, dimethyldiallylammonium chloride, and acrylic acid and / or acrylamide. By using one or more polymers selected from a combination, in particular a dimethyldiallylammonium chloride / acrylic acid copolymer, and a polymer selected from an acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer in a specific blending amount, These components act synergistically to enhance the crystallization of calcium ions and phosphate ions in the tooth enamel, that is, remineralization, and improve the storage stability of calcium ions and monofluorophosphate ions over time. More than 70% remains after 1 month storage at 40 ° C , Calcium ions and monofluorophosphate ions can be satisfactorily supplied to the enamel over time, and can exert an excellent remineralization promoting effect. Moreover, when used, astringency, bitterness, pungent taste, poor aftertaste, Furthermore, it also has a good feeling of use with little stickiness. Such operational effects of the present invention can be achieved by combining and blending the above-mentioned specific components. Even if any of the components is absent, the cellulose-based polymer substance is used instead of the polymer of component (C). In addition to using calcium glycerophosphate as the component (B), other water-soluble calcium ion supplying substances such as calcium lactate or organic acids such as malic acid can be added. It is clear from the results of Examples described later.

Accordingly, the present invention provides the following oral composition.
Claim 1:
(A) Monofluorophosphate 0.1-2.0% by mass,
(B) calcium glycerophosphate 0.1-2.0 mass%,
(C) One or more polymers selected from a copolymer of polydimethyldimethylmethylenepiperidinium chloride, dimethyldiallylammonium chloride and acrylic acid and / or acrylamide
0.1-1.0% by mass
A composition for oral cavity, comprising:
Claim 2:
The oral composition according to claim 1, wherein the polymer of component (C) is selected from a copolymer of dimethyldiallylammonium chloride and acrylic acid, and a copolymer of dimethyldiallylammonium chloride, acrylic acid and acrylamide. .
Claim 3:
The oral composition according to claim 1 or 2, which is prepared as a liquid preparation.

  The composition for oral cavity of the present invention is excellent in the effect of promoting remineralization of tooth enamel, the monofluorophosphate ion and calcium ion are stably stored over time, the feeling of use is good, and there is no stickiness. It is effective as a preparation for suppressing and preventing caries.

  Hereinafter, the present invention will be described in more detail. The composition for oral cavity of the present invention contains (A) monofluorophosphate, (B) calcium glycerophosphate, and (C) a specific polymer.

  (A) As monofluorophosphate, monofluorophosphate ions may be supplied, and water-soluble monofluorophosphates such as alkali metal salts, alkaline earth metal salts, and ammonium salts of monofluorophosphate are exemplified. Is done. Specific examples include sodium monofluorophosphate, potassium monofluorophosphate, ammonium monofluorophosphate, and sodium monofluorophosphate is particularly preferred.

  As the monofluorophosphate, a commercially available product can be used, and examples of sodium monofluorophosphate include a commercial product (trade name: Sodium Monofluorphosphate) manufactured by Albright & Wilson UK Limited.

  The blending amount of the monofluorophosphate is 0.1 to 2.0% (mass%, the same shall apply hereinafter) of the whole composition from the viewpoint of the remineralization effect, the stability of the monofluorophosphate ion, and the feeling of use. In particular, 0.7 to 1.5% is preferable. If the blending amount is less than 0.1%, a sufficient remineralization effect cannot be obtained and the stability of monofluorophosphate ions is inferior. If it exceeds 2.0%, the stability of monofluorophosphate ions and calcium ions is poor. It becomes worse and astringency, bitterness, etc. become stronger and the feeling of use is inferior.

  (B) The calcium glycerophosphate can be a natural product or a synthetic product. For example, a commercially available product such as “Calcium glycerophosphate” manufactured by Iwaki Pharmaceutical Co., Ltd. can also be used.

  The blending amount of calcium glycerophosphate is 0.1 to 2.0% of the total composition, particularly 0.1 to 0.5% from the viewpoint of remineralization effect, calcium ion stability and usability. . If the blending amount is less than 0.1%, a sufficient remineralization effect cannot be obtained and the stability of calcium ions is poor, and if it exceeds 2.0%, the stability of monofluorophosphate ions and calcium ions is poor. , Astringency, bitterness, etc. become stronger and the feeling of use is poor.

  The polymer of the component (C) is selected from polydimethyldimethylmethylenepiperidinium chloride, a copolymer of dimethyldiallylammonium chloride and acrylic acid and / or acrylamide.

  As the polymer of component (C), polydimethylmethylenepiperidinium chloride, dimethyldiallylammonium chloride / acrylamide copolymer, dimethyldiallylammonium chloride / acrylic acid copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer Among them, dimethyldiallylammonium chloride / acrylic acid copolymer and acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer are particularly preferable from the viewpoint of the stability of calcium ions.

The said polymer can use a commercial item, and the following are mentioned specifically.
Polydimethyldimethylmethylene piperidinium chloride:
Marcote 100, Marcote 106 manufactured by Nalco Corporation
Dimethyldiallylammonium chloride / acrylamide copolymer:
Marcote 550, Marcote 550PR, Marcote S, Marcote 7SPR, Marcote 2200 made by Nalco Co., Ltd.
Dimethyldiallylammonium chloride / acrylic acid copolymer:
MARCOAT 280, MARCOAT 281, MARCOAT 280SD, MARCOAT 295, manufactured by Nalco Corporation
Acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer:
MARCOAT PLUS 3330, MARCOAT 3330PR, MARCOAT 3330DRY, MARCOAT PLUS 3331, MARCOAT 3331PR, MARCOAT 3940 manufactured by Nalco Co., Ltd.

These commercial products are marketed in the form of aqueous solutions or polymer powders, and any form can be used, but those in aqueous solution are preferred. Examples of the aqueous solution include the following commercially available products.
Marcote 100:
Solid content 39 to 44.2%, viscosity 8,000 to 12,000 mPa · s (Brookfield viscometer LVF, spindle No. 3, 6 revolutions / minute, 25 ° C.)
Marcote 106:
Solid content 30 to 36%, viscosity 20 to 65 mPa · s (Brookfield viscometer LVF, spindle No. 1, 60 revolutions / minute, 25 ° C.)
Marcote 550:
Solid content of 8.5 to 9.5%, viscosity of 7,500 to 15,000 mPa · s (Brookfield viscometer RVF, spindle No. 4, 10 revolutions / minute, 25 ° C.)
Marcote 550PR:
Solid content: 8.8 to 9.8%, viscosity: 7,500 to 15,000 mPa · s (Brookfield viscometer RVF, spindle No. 4, 10 revolutions / minute, 25 ° C.)
Marcote S:
Solid content of 8.5 to 9.5%, viscosity of 9,000 to 15,000 mPa · s (Brookfield viscometer RVF, spindle No. 4, 10 revolutions / minute, 25 ° C.)
Marcote 7SPR:
Solid content 8.8 to 9.8%, viscosity 9,000 to 15,000 mPa · s (Brookfield viscometer RVF, spindle No. 4, 10 revolutions / minute, 25 ° C.)
Marcote 280:
Solid content 39 to 43%, viscosity 3,000 to 6,000 mPa · s (Brookfield viscometer LVF, spindle No. 4, 60 rpm), 25 ° C.
Marcote 281:
Solid content 39 to 43%, viscosity 4,000 to 15,000 mPa · s (Brookfield viscometer LVF, spindle No. 4, 60 rpm), 25 ° C.
Marcote 295:
Solid content 35-40%, viscosity 3,500-9,000 mPa · s (Brookfield viscometer LVF, spindle No. 4, 30 rev / min, 25 ° C.)
Marcote 3330PR:
Solid content 9.7 to 10.7%, viscosity 2,000 to 8,000 mPa · s (Brookfield viscometer LVF, spindle No. 4, 30 revolutions / minute, 25 ° C.)
Marcote 3330:
Solid content 9.4 to 10.4%, viscosity 4,000 to 10,000 mPa · s (Brookfield viscometer LVF, spindle No. 4, 30 revolutions / minute, 25 ° C.)
Marcote PLUS3331:
Solid content 9.4 to 10.4%, viscosity 5,500 to 16,000 mPa · s (Brookfield viscometer LVF, spindle No. 4, 30 revolutions / minute, 25 ° C.)
Marcote 3331PR:
Solid content of 9.7 to 10.7%, viscosity of 2,000 to 12,000 mPa · s (Brookfield viscometer LVF, spindle No. 5, 30 revolutions / minute, 25 ° C.)
Marcote 3940:
Solid content 41.0-45.0%, viscosity 1,500-4,500 mPa · s (Brookfield viscometer LVF, spindle No. 3, 10 revolutions / minute, 25 ° C.)

  As the component (C), one of the above polymers can be used alone, or two or more of them can be used in combination, and the blending amount thereof includes a remineralization effect, a feeling of use, a sticky feeling, a monofluorophosphate ion and a calcium ion. From the point of storage stability over time, it is 0.1 to 1.0% of the total composition, preferably 0.1 to 0.5% in terms of solid content. If the blending amount is less than 0.1%, a sufficient remineralization effect cannot be obtained, and there is a problem in the stability of monofluorophosphate ions and calcium ions. It becomes too high and a sticky feeling is produced, and astringency, bitterness, etc. become strong and the feeling of use is inferior.

  The composition for oral cavity according to the present invention can be made into various forms such as solid, solid, liquid, liquid, gel, paste, gum and the like, such as toothpaste, liquid toothpaste, liquid toothpaste, and toothpaste. It can be prepared in various dosage forms such as dentifrices, mouthwashes, mouthwashes, etc., but it is particularly suitably prepared for liquid preparations such as mouthwashes, and its production method can employ conventional methods according to the dosage form.

In addition to the above-described essential components (A) to (C), the composition of the present invention can further contain appropriate optional components other than these components, depending on the purpose and dosage form of the composition. .
Liquid preparations such as mouthwashes can contain, for example, wetting agents, surfactants, alcohols, solvents, organic acids, preservatives, bactericides, fragrances, sweeteners, colorants, active ingredients and medicinal ingredients. Furthermore, you may mix | blend an abrasive | polishing agent and a binder with liquid formulations, such as a mouthwash, as needed. In the case of a dentifrice such as toothpaste, for example, abrasives, thickeners, binders, alcohols, surfactants, sweeteners, fragrances, colorants, preservatives, active ingredients and medicinal ingredients can be blended.

  Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrous, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, carbonic acid Magnesium, tribasic magnesium phosphate, zeolite, zirconium silicate, synthetic resin-based abrasive and the like are preferably used. In the case of dentifrice, the blending amount of these abrasives is preferably 2 to 40%, particularly preferably 10 to 30% of the whole composition. When mix | blending with a liquid formulation, 0 to 5% is good.

  As a thickening agent (wetting agent), one or more of sugar alcohols such as sorbit and xylitol, glycerin, propylene glycol, and polyethylene glycol 200 to 20000 can be blended. The blending amount of the thickening agent is preferably 5 to 50%, particularly 20 to 45% of the whole composition.

Examples of the alcohol include lower monohydric alcohols having 2 to 4 carbon atoms such as ethanol, isopropanol, butanol and propanol, divalent or 3 such as ethylene glycol, diethylene glycol, hexylene glycol, butylene glycol, pentanediol, and polypropylene glycol 300 to 4000. Can be mentioned, and one or more of these can be blended. The blending amount of these alcohols is preferably 1 to 30%, particularly 2 to 20% of the whole composition.
As the solvent, purified water is generally used.

  Examples of the binder include inorganic and organic binders such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, carbopol, guar gum, montmorillonite, and gelatin. The compounding quantity of a binder can be adjusted with a dosage form, 0.1-5% can be mix | blended with a toothpaste, and 0-5% can be mixed with a liquid dentifrice and a mouthwash.

  As the organic acid, various organic acids that can be usually blended in oral compositions can be used, for example, citric acid, isocitric acid, malic acid, acetic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, maleic acid, fumaric acid. Examples include acids, aconitic acid, lactic acid, tartaric acid, pyruvic acid, ascorbic acid, glycolic acid, and the like, and salts of these organic acids may be blended. These organic acids can be used alone or in combination of two or more. Among them, citric acid, malic acid, tartaric acid, lactic acid, and salts thereof are preferable.

As the surfactant, an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.
Examples of the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosinate such as sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosinate, sodium dodecylbenzene sulfonate, Hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, N-methyl-N-acyl taurine sodium, N-methyl-N-acylalanine sodium, α-olefin Sodium sulfonate, sodium dioctyl sulfosuccinate and the like are used.

  Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters and lactose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters and lactitol fatty acid esters, polyoxyethylene sorbitan monolaurate, poly Polyoxyethylene fatty acid esters such as polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, fatty acid diethanolamides such as lauric acid mono or diethanolamide, myristic acid mono or diethanolamide, sorbitan fatty acid esters, fatty acid monoglycerides, polyoxy Ethylene hydrogenated castor oil, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer Polyoxyethylene polyoxypropylene fatty acid ester or the like is used.

Examples of zwitterionic surfactants include N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, and 2-alkyl-1-hydroxyethylimidazoline. Examples include betaine sodium, N-alkyl-lauryldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium, and the like.
The blending amount of these surfactants is preferably 0.1 to 10%, particularly 0.2 to 5% of the whole composition.

Sweeteners include saccharin sodium, erythritol, lactitol, maltitol, mannitol, palatinose, reduced palatinose (palatinite), thaumatin, aspartame, acesulfame K, cyclamate sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesberyl dihydro Examples include chalcone, perilartin, p-methoxycinnamic aldehyde, trehalose, palatinose, palatinit, soybean oligosaccharide, dairy oligosaccharide, xylooligosaccharide, L-aspartyl-L-phenylalanine methyl ester, sucralose, glycyrrhizin and the like. As a preservative, paraoxybenzoic acid ester, benzoic acid or a salt thereof can be blended.
As colorants, Blue No. 1, Blue No. 2, Red No. 2, Red No. 3, Red No. 40, Red No. 102, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, paprika pigment, titanium dioxide, etc. can be blended in normal amounts.

  As medicinal ingredients and active ingredients, in addition to (A) component monofluorophosphate and (B) ingredient calcium glycerophosphate, other than these, such as sodium azulenesulfonate, ε-aminocaproic acid, allantoin, allantoinchlor Allantoins such as hydroxyaluminum and allantoindihydroxyaluminum, epidihydrocholesterin, dihydrocholesterol, sodium chloride, glycyrrhizic acid, diammonium glycyrrhizinate, disodium, trisodium, dipotassium, monoammonium glycyrrhizic acid and its salts, β -Nonionic fungicides such as glycyrrhetinic acid, isopropylmethylphenol, and cationic properties such as cetylpyridinium chloride, decalinium chloride, benzalkonium chloride, benzethonium chloride Bactericides, alkyldiaminoethylglycine hydrochloride, chlorhexidine hydrochloride, triclosan, ascorbic acid, ascorbic acid and its salts such as sodium ascorbate, pyridoxine hydrochloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, zeolite, pyrophosphate Disodium dihydrogen, sodium pyrophosphate, anhydrous sodium pyrophosphate, sodium monohydrogen phosphate, trisodium phosphate, sodium polyphosphate, sodium fluoride, tin fluoride, polyvinylpyrrolidone such as polyvinylpyrrolidone K25, K30, K90, chloride Enzymes such as lysozyme, sodium copper chlorophyllin, hinokitiol, tranexamic acid, dextranase, protease, aluminum lactate, potassium nitrate, etc. The The compounding quantity of the said medicinal component can be made into an effective quantity in the range which does not prevent the effect of this invention (mixing quantity usually 0.001 to 5%).

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractionation, essence, powdered fragrance, etc. ) Fragrance, menthol, carvone Anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentan-3- Carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, Butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethylthioacetate Oral compositions such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above. Usually, the blending amount is in the range of 0.00001 to 2%.

  The pH of the oral composition is preferably in the range of 5.0 to 9.0, and particularly preferably 6.0 to 8.0.

  EXAMPLES Hereinafter, although an experimental example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%. The blending amount of the polymer is a solid content conversion value.

[Experimental example]
Test compositions (mouthwash) having the compositions shown in Tables 1 to 5 were prepared by the following method and evaluated by the following method. The results are also shown in Tables 1-5.

Methods for preparing test compositions (comparative examples and examples):
For the calcium lactate, lactic acid, malic acid, hydrochloric acid, and sodium hydroxide, special reagent grades of Wako Pure Chemical Industries, Ltd. were used. Sodium monofluorophosphate is “Sodium Monofluorophosphate” from Albright & Wilson UK Limited, calcium glycerophosphate is “calcium glycerophosphate” manufactured by Iwaki Pharmaceutical Co., Ltd., and polydimethylmethylenepiperidinium is a marcoat 100 manufactured by Nalco Corporation The dimethyldiallylammonium chloride / acrylamide copolymer is Marcote 550 manufactured by Nalco Co., Ltd., and the dimethyldiallylammonium chloride / acrylic acid copolymer is Marcote 280 manufactured by Nalco Co., Ltd., acrylamide / acrylic acid / dimethyldiallyl chloride. Ammonium copolymer is weighed to a predetermined concentration using Marcote 3330PR manufactured by Nalco Co., Ltd., and the total amount is 100 g by adding purified water. Sea urchin was prepared. Thereafter, the material dispersed and dissolved by stirring for one day at room temperature was immediately used for the experiment.
The pH of the compositions was adjusted to pH 7.0 in Examples and Comparative Examples 1 to 18 with hydrochloric acid and sodium hydroxide, and adjusted to pH 5.0 in Comparative Examples 19 and 20.

  Marcoat 100 has a viscosity of 9,020 mPa · s (Brookfield Viscometer LVF, spindle No. 3, 6 revolutions / minute, 25 ° C.), and Marcoat 550 has a viscosity of 10,580 mPa · s (Brookfield Viscometer RVF, spindle No. , 10 revolutions / minute, 25 ° C.), Marcoat 280 has a viscosity of 4,210 mPa · s (Brookfield Viscometer LVF, spindle No. 4, 60 revolutions / minute, 25 ° C.), and Marcoat 3330PR has a viscosity of 4, 140 mPa · s (Brookfield viscometer LVF, spindle No. 4, 30 revolutions / minute, 25 ° C.) was used.

  In the comparative example, hydroxyethyl cellulose dimethyldiallylammonium chloride is Cellcoat L-200 manufactured by Nippon NSC Co., Ltd., and the viscosity of a 5% aqueous solution is 9,330 mPa · s (BH viscometer manufactured by Tokyo Keiki Co., Ltd., spindle No. 4). , 20 rotations / min, 25 ° C., 1 min), O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethylcellulose chloride has a viscosity of 3% by marcoat 10 manufactured by Nalco Co., Ltd. , 610 mPa · s (manufactured by Tokyo Keiki Co., Ltd., BH type viscometer, spindle No. 4, 20 revolutions / minute, 25 ° C., 1 minute).

(I) Evaluation of remineralization effect Kasushi Oshino et al. The following experiment was conducted according to the description of Oral Hygiene Journal 54: 2-8,2004.
Preparation of decalcified sample:
The enamel portion of the bovine teeth was divided into crosses with a hard tissue cutting machine (Isomet 2000, Buehler) to produce 4 enamel blocks per tooth. The enamel surfaces of these blocks were mirror polished and coated with nail enamel so that an approximately 4 × 4 mm window was exposed. The enamel block is immersed in a demineralization solution having the following composition (described as the composition of the demineralization solution and the remineralization solution) and left at 37 ° C. for 3 days to form an artificial surface demineralized lesion. I let you.

Remineralization treatment:
Demineralized samples (5 blocks for each group) were immersed in the test compositions of Tables 1-5 for 5 minutes twice a day (around 9 and 18:00). The demineralized sample after immersion was cleaned for about 10 seconds with a toothbrush (PC CLINICA IONHABRUSH standard) on the window surface, washed for about 30 seconds under running tap water, and then remineralized with the following composition in blocks. It was immersed in 10 ml of the solution and kept at 37 ° C. This remineralization solution is similar to the plaque fluid composition 30 minutes after ingestion of sucrose and is supplemented with acid phosphatase having MFPase activity (derived from P-3627 wheat). . This series of operations continued for 14 days.

Measurement of mineral loss by Contact microradiography (CMR):
The sample after demineralization and remineralization treatment is resin-embedded (Rigolac 2004: Permec N: Promoter E = 120: 1: 1, Oken Shoji Co., Ltd.), solidified, and then hard tissue cutting machine (Isomet 2000) Was cut into a thickness of 300 μm, and a polished slice sample having a thickness of about 150 μm was obtained with an automatic polishing machine (Speedlap ML-150DC, Marto). Each section was subjected to CMR imaging (SO-343, SO-343, with an aluminum step for a calibration curve using a soft X-ray generator (CMR-III, Softex) under the conditions of current 3 mA, voltage 20 kV, and X-ray irradiation time 20 minutes. Kodak). Under the microscope (OPTIPHOTO T2, Nikon), the CMR image of the subsurface demineralized part was taken with a camera (HD camera model HQ-130, Nikon) and enameled using image analysis software (WinRoof V3.0, Mitani). The mineral concentration from the surface layer to the deep layer was analyzed. The background and healthy enamel mineral concentrations were 0 and 100%, respectively, and the mineral loss amount (ΔZ; vol% · μm) of the polished slice sample was measured and calculated from these mineral concentration profiles. The demineralized sample and the amount of mineral loss ΔZ after remineralization were measured, and the remineralization rate of each group was calculated.

The remineralization rate was evaluated according to the following criteria.
Remineralization rate is 60% or more ◎
Remineralization rate is 50% or more and less than 60% ○
Remineralization rate is 40% or more and less than 50% △
Remineralization rate is less than 40% ×

Composition of decalcification solution and remineralization solution:
Component Demineralization solution Remineralization solution CaCl ₂ ^{* 1} 3.0 mmol / L 2.0 mmol / L
KH ₂ PO ₄ ^{* 1} 1.8 mmol / L 10 mmol / L
Lactic acid ^{* 1} 20mmol / L 40mmol / L
Sodium lactate ^{* 1} 80mmol / L-
NaCl ^{* 1} -30 mmol / L
KOH ^{* 1} -Appropriate amount Acid phosphatase ^* 2-0.025 units / mL
Hydroxyethyl cellulose ^{* 1} 5.0% −
pH 4.5 6.0
* 1: Wako Pure Chemical Industries, Ltd.
* 2: Sigma Aldrich Japan Co., Ltd.

(II) Sensory evaluation Ten test subjects (8 males and 2 females) washed their mouth using test solutions prepared by dissolving the test compositions shown in Tables 1 to 5 in distilled water. The feeling of use and the feeling of stickiness that combined the strength of the pungent taste and the good aftertaste were subjected to sensory evaluation in five stages according to the following criteria. The result was shown by the average value of the scores of 10 subjects. In addition, sensory evaluation was performed using distilled water as a control and using the distilled water for 5 points.

Evaluation criteria for feeling of use (overall) 5: Good 4: Slightly good 3: Not good 2: Slightly bad 1: Bad Evaluation criteria for non-stickiness 5: No stickiness 4: Slightly sticky feel 3: There is a little sticky feeling 2: There is a sticky feeling 1: There is a strong sticky feeling

Judgment criteria:
Average value of 4 points or more ◎
Average value 3 points or more and less than 4 points ○
Average value 2 points or more and less than 3 points △
Average value less than 2 points ×

(III) Evaluation of Stability of Monofluorophosphate Ion and Calcium Ion After storing the test composition at 40 ° C. for 1 month, it was filtered with a membrane filter (Sterile Millex Filter Unit 0.22 μm (Millipore Corporation)), Monofluorophosphate ion and calcium ion were measured for the filtrate. From the values of monofluorophosphate ion and calcium ion before and after storage, the residual ratio of each test composition after storage at 40 ° C. for 1 month was determined before storage (each test composition was evaluated at n = 3). .
Residual rate of monofluorophosphate ion (MFP) (%) =
(MFP amount after saving / MFP amount before saving) × 100
Calcium ion (Ca) residual rate (%) =
(Ca amount after storage / Ca amount before storage) × 100

Calcium ions were quantified with an atomic absorption device (Hitachi Ltd. Z5310). Monofluorophosphate ions were quantified by a calibration curve method using ion chromatography. An ICS-2000 manufactured by Nippon Dionex Co., Ltd. was used as the ion chromatography apparatus.
Measurement condition:
Separation column IonPac AS-20
Guard column IonPac NG-1
Eluent 55 mM KOH (2 mM at equilibrium)
Flow rate 1.2mL / min
Suppressor ASRS-ULTRA II (137 mA)
Detector Use electrical conductivity detector Sample introduction volume 20μL
Column temperature 30 ° C
Detector temperature 35 ℃
With respect to monofluorophosphate ions and calcium ions, the stability after storage at 40 ° C. for 1 month was evaluated according to the following criteria.
Stability Residual rate is 90% or more before storage ◎
Residual rate is 70% or more and less than 90% before storage ○
Residual rate is 50% or more and less than 70% before storage.
Residual rate is less than 50% before storage ×

  From the results of Tables 1 to 5, sodium monofluorophosphate, calcium glycerophosphate, polydimethylmethylenepiperidinium chloride, dimethyldiallylammonium chloride / acrylamide copolymer, dimethyldiallylammonium chloride / acrylic acid copolymer, acrylamide When combined with one or more polymers selected from acrylic acid / dimethyldiallylammonium chloride copolymer (Example), it has excellent remineralization effect and storage stability over time of monofluorophosphate ion and calcium ion, The feeling of use was also good.

On the other hand, when any of the essential requirements of the present invention is lacking, it is inferior to any of the remineralization effect, feeling of use, stickiness, storage stability of monofluorophosphate ions and calcium ions, The objective could not be achieved (comparative example).
When calcium lactate is used instead of calcium glycerophosphate, the remineralization effect and the feeling of use are inferior (Comparative Example 16), and the polymer is hydroxyethylcellulose dimethyl diallylammonium chloride, O- [2-hydroxy-3- (trimethylammonio) chloride. When) propyl] hydroxyethylcellulose was used, the remineralization effect was poor and the storage stability of monofluorophosphate ions and calcium ions was also poor (Comparative Examples 17 and 18). Furthermore, even when malic acid and lactic acid were blended, when a suitable polymer was not blended, a satisfactory remineralization effect was not obtained, and the usability was also poor (Comparative Examples 19 and 20).
In addition, sodium fluoride was compared with sodium monofluorophosphate using the same fluorine concentration (Example 8 and Comparative Example 15), but sodium fluoride showed a significant improvement in the remineralization effect. Therefore, the object of the present invention could not be achieved. This is probably because sodium fluoride forms insoluble calcium fluoride in the presence of calcium ions and the remineralization effect of fluorine is weakened.

An oral composition having the following composition was prepared and evaluated in the same manner as described above.
In the following examples, sodium monofluorophosphate and calcium glycerophosphate, polydimethylmethylenepiperidinium chloride (Mercoat 100), dimethyldiallylammonium chloride / acrylamide copolymer (Mercoat 550), dimethyldiallylammonium chloride / acrylic acid copolymer ( The same as the above was used as the mercoat 280) and the acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer (Mercoat 3330PR).
Marcote 295 is manufactured by Nalco Co., Ltd. and has a viscosity of 6,170 mPa · s (Tokyo Keiki Co., Ltd., BH viscometer, spindle No. 5, 20 revolutions / minute, 25 ° C., 1 minute). A Nalco Co., Ltd. product having a viscosity of 10,050 mPa · s (Tokyo Keiki Co., Ltd. BH type viscometer, spindle No. 5, 20 revolutions / minute, 25 ° C., 1 minute) was used.

[Example 39] Toothpaste silica 20.0%
Propylene glycol 3.0
Glycerin 18.0
Sodium carboxymethylcellulose 1.4
Sodium monofluorophosphate 0.76
Calcium glycerophosphate 0.5
Marcote 100 0.5
Erythritol 2.0
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Sodium fluoride 0.21
Fragrance 0.8
Purified water balance
Total 100.0%

[Example 40] Toothpaste, aluminum hydroxide 42.0%
Propylene glycol 3.0
70% sorbit 25.0
Sodium carboxymethylcellulose 1.2
Sodium monofluorophosphate 0.8
Calcium glycerophosphate 0.4
Marcote 550 0.3
Melibiose 2.0
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 41] Toothpaste Heavy calcium carbonate 25.0%
Propylene glycol 3.0
70% sorbit 30.0
Sodium carboxymethylcellulose 1.2
Sodium monofluorophosphate 1.3
Calcium glycerophosphate 0.2
Marcote 280 0.8
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 42] Toothpaste silica 17.0%
Propylene glycol 3.0
70% sorbit 25.0
Sodium carboxymethylcellulose 1.2
Sodium monofluorophosphate 0.08
Calcium glycerophosphate 1.2
Marcote 3330PR 0.3
Palatinose 2.5
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 43] Toothpaste Dicalcium phosphate 46.0%
Propylene glycol 3.0
70% sorbit 28.0
Sodium carboxymethylcellulose 1.2
Sodium monofluorophosphate 0.8
Calcium glycerophosphate 0.3
Marcote 295 0.3
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 44] Mouthwash glycerin 8.0%
Ethanol 8.0
Sodium monofluorophosphate 1.2
Calcium glycerophosphate 1.2
POE hydrogenated castor oil (100EO) 0.8
MARCOAT PLUS3331 0.9
Melibiose 12.0
Erythritol 5.0
Sodium citrate 0.1
Citric acid 0.3
Sodium benzoate 0.5
Fragrance 0.2
Purified water balance
Total 100.0%

[Example 45] Mouth freshener Glycerin 13.0%
Ethanol 40.0
POE hydrogenated castor oil (60EO) 2.0
Sodium monofluorophosphate 0.6
Calcium glycerophosphate 0.2
Marcote 550 0.5
Raffinose 1.0
Reduced palatinose 1.5
Xylitol 2.0
Sodium citrate 0.1
Citric acid 0.03
Fragrance 0.4
l-Menthol 0.5
Purified water balance
Total 100.0%

  The compositions for oral cavity of these examples all showed a high remineralization promoting effect, good usability, no stickiness, and excellent storage stability of calcium ions and monofluorophosphate ions.

Claims (3)

(A) Monofluorophosphate 0.1-2.0% by mass,
(B) calcium glycerophosphate 0.1-2.0 mass%,
(C) One or more polymers selected from a copolymer of polydimethyldimethylmethylenepiperidinium chloride, dimethyldiallylammonium chloride and acrylic acid and / or acrylamide
0.1-1.0% by mass
A composition for oral cavity, comprising:   The oral composition according to claim 1, wherein the polymer of component (C) is selected from a copolymer of dimethyldiallylammonium chloride and acrylic acid, and a copolymer of dimethyldiallylammonium chloride, acrylic acid and acrylamide. .   The oral composition according to claim 1 or 2, which is prepared as a liquid preparation.