JP7075291B2 - Oral composition - Google Patents

Description

The present invention relates to an oral composition.

In healthy teeth, the dentin of the teeth is usually covered with gingiva or tooth enamel. However, when gingival retraction or tooth enamel damage occurs due to gingival inflammation, aging, or improper brushing with excessive load, the dentin is exposed on the tooth surface and the surface of the dentin is exposed. The nerves are stimulated through the dentin tubules that are open in the dentin, causing so-called hypersensitivity, which causes pain and irritation. In order to suppress pain and the like caused by such hypersensitivity, it is a direct effective method to block the opening of the dentin tubule on the surface of the exposed dentin, and therefore, various oral compositions. Has been developed.

For example, Patent Document 1 describes a toothpaste composition in which a sparingly water-soluble powder selected from a specific fatty acid divalent metal salt, a fatty acid acyl lysine, and a fatty acid acyl taurine divalent metal salt and a specific desensitizing agent are used in combination with water. A substance is disclosed, and Patent Document 2 contains a desensitizing agent such as potassium nitrate, a specific fatty acid or an alkali metal salt thereof, and water, and dentin hypersensitivity adjusted to a specific pH range. Oral compositions are disclosed, both of which can effectively block the openings of dentinal tubules on the surface of exposed dentin.

Japanese Unexamined Patent Publication No. 2013-1648 Japanese Unexamined Patent Publication No. 2015-124216

On the other hand, for those who are aware of such hypersensitivity, they are experiencing so-called deterioration of the tooth structure, which is expressed by the feeling that the teeth are thin or easy to put on. The number of cases is increasing. When the tooth quality deteriorates, cracks and acid erosion are likely to occur, and tooth fracture is also likely to occur due to impact, etc., so these can be indirect factors that cause hypersensitivity. .. Therefore, in order to suppress pain due to hypersensitivity in all situations, an oral composition that can not only block the opening of the dentin tubule but also strengthen the dentin. Is where the realization of is desired.

However, although the composition described in Patent Document 1 exhibits a high sealing ability for the opening of the dentin capillary tube, the strengthening of the dentin by the uptake of fluorine ions has not been studied in detail. Further, although the composition described in Patent Document 2 contains a fluorine ion supply compound which is a component that promotes remineralization in some specific examples, the supplied fluorine ions may be coexisting zinc or the like. Since unnecessary fluoride metal salts are formed together with polyvalent metals, further improvement is required to secure a sufficient amount of fluorine ions taken up on the tooth surface and contribute to strengthening the tooth structure. It is in.

That is, the present invention exerts the effect of blocking the opening of the dentin tubule, and can also effectively take in fluorine ions not only on the tooth surface but also up to the opening of the dentin tubule to strengthen the dentin. The present invention relates to an oral composition capable of effectively and effectively suppressing pain and the like for all users having symptoms of hypersensitivity.

Therefore, as a result of diligent studies to solve the above problems, the present inventor used a fatty acid divalent metal salt together with calcium glycerophosphate in a specific content and a specific mass ratio while containing a specific fluorine ion supply compound. By doing so, it has been found that an oral composition capable of sufficiently combining the effect of closing the opening of the dentin tubule and the effect of strengthening the dentin can be obtained.

Therefore, in the present invention, the following components (A) to (C):
(A) One or two fluorine ion supply compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass or more and 1.3% by mass or less (C) Carbon number 12 or more and 18 or less Fatty acid divalent metal salt derived from saturated fatty acid of No. 0.5% by mass or more and 6% by mass or less, and the mass ratio of the content of the component (B) to the content of the component (C) ((B)) / (C)) provides an oral composition having a value of 0.12 or more and 1.5 or less.

According to the oral composition of the present invention, not only can the opening of the dentin tubule on the surface of the exposed dentin be effectively closed, but also the tooth surface and the opening of the dentin tubule can be fluorinated. It is possible to sufficiently increase the uptake of dentin, effectively strengthen the dentin, and effectively suppress the pain and irritation caused by hyperesthesia.
Therefore, by using the oral composition of the present invention, not only the user who has the dentin of the tooth exposed due to the regression of the gingiva due to the progression of gingival inflammation or aging, but also the enamel of the tooth. Even for users whose dentin is exposed due to damage to the gingiva, it is possible to promote remineralization and strengthen the gingiva while blocking the opening of the dentin tubule. Therefore, it is possible to effectively alleviate the symptoms of hyperesthesia in various situations.

It is a photograph which shows the opening of the dentin tubule before using the toothpaste composition of Example 7. It is a photograph which shows the appearance that the opening of the dentin tubule is closed after using the toothpaste composition of Example 7.

Hereinafter, the present invention will be described in detail.
The oral composition of the present invention has the following components (A) to (C):
(A) One or two fluorine ion supply compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass or more and 1.3% by mass or less (C) Carbon number 12 or more and 18 or less Fatty acid divalent metal salt derived from saturated fatty acid of No. 0.5% by mass or more and 6% by mass or less, and the mass ratio of the content of the component (B) to the content of the component (C) ((B)) / (C)) is 0.12 or more and 1.5 or less.
The oral composition of the present invention may be used as a dentifrice composition such as a dentifrice or a powdered dentifrice, or as a liquid oral composition such as a mouthwash or a liquid dentifrice, depending on the intended use. It is a composition that can be used.
In the present invention, "sealing the opening of the dentin tubule" means physically sealing the dentin tubule, and only in a state of covering the opening of the dentin tubule on the surface of the dentin. It also means that the dentin tubules are filled in the tubules near the surface and the lid is closed (plugged).

The oral composition of the present invention contains, as the component (A), one or two fluorine ion supply compounds selected from sodium fluoride and tin fluoride. The component (A) releases fluorine ions when the oral composition of the present invention is applied into the oral cavity, and the fluorine ions are effective and efficient together with the calcium ions released from the component (B) described later. Calcium fluoride particles can be formed while trying to make the particles finer. Then, since the finely divided calcium fluoride can be efficiently adsorbed on the tooth surface and the dentin tubule without impairing the sealing ability of the opening of the dentin tubule, the amount of fluorine ion adsorbed is effectively increased. Therefore, it can promote remineralization of teeth and exert an excellent effect on strengthening dentin.

The content of the component (A) is preferably 0 in the oral composition of the present invention from the viewpoint of effectively increasing the adsorption rate of fluorine ions on the tooth surface and the dentin capillary tube in combination with the component (B) described later. It is 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.15% by mass or more, still more preferably 0.25% by mass or more. In addition, the content of the component (A) efficiently increases the adsorption rate of fluorine ions on the tooth surface and the dentin capillary tube, and does not unnecessarily reduce the sealing ability of the opening of the dentin capillary tube. In the oral composition of the present invention, it is preferably 1% by mass or less, more preferably 0.8% by mass or less, still more preferably 0.5% by mass or less, still more preferably 0.4% by mass. % Or less. The content of the component (A) is preferably 0.01% by mass or more and 1% by mass or less, and more preferably 0.1 to 0.8% by mass in the oral composition of the present invention. It is more preferably 0.15 to 0.5% by mass, and even more preferably 0.25 to 0.4% by mass.
From the same viewpoint as above, the fluorine atom equivalent amount of the component (A) is preferably 0.005% by mass or more, more preferably 0.05% by mass or more in the oral composition of the present invention. It is more preferably 0.07% by mass or more, and even more preferably 0.11% by mass or more. Further, the fluorine atom equivalent amount of the component (A) is preferably 0.4% by mass or less, more preferably 0.35% by mass or less in the oral composition of the present invention from the same viewpoint as above. Yes, more preferably 0.25% by mass or less, still more preferably 0.2% by mass or less. The fluorine atom equivalent amount of the component (A) is preferably 0.005 to 0.4% by mass, more preferably 0.05 to 0.35% by mass in the oral composition of the present invention. Yes, more preferably 0.07 to 0.25% by mass, and even more preferably 0.11 to 0.2% by mass.

The oral composition of the present invention contains calcium glycerophosphate in an amount of 0.35% by mass or more and 1.3% by mass or less as the component (B). As a result, an unnecessary calcium salt that does not inhibit the sealing ability of the opening of the dentin capillary tube exhibited by the oral composition of the present invention and inhibits the adsorption of fluorine ions on the tooth surface and the dentin capillary tube. It is possible to effectively and effectively increase the adsorption rate of fluorine ions on the tooth surface and the dentin tubules in combination with the fluorine ions released by the component (A) while effectively suppressing the formation of the dentin.

The content of the component (B), in combination with the component (A), forms finely divided calcium fluoride particles, and effectively and effectively increases the amount of fluorine ions adsorbed on the tooth surface and the dentin tubules to make the tooth substance. In the oral composition of the present invention, it is 0.35% by mass or more, preferably 0.44% by mass or more, more preferably 0.46% by mass or more, and further. It is preferably 0.48% by mass or more. Further, the content of the component (B) is contained in the oral composition of the present invention from the viewpoint of not unnecessarily reducing the amount of fluorine ions adsorbed on the tooth surface and the dentin capillary tube and the ability to block the opening of the dentin capillary tube. , 1.3% by mass or less, preferably 1.1% by mass or less, more preferably 0.85% by mass or less, still more preferably 0.7% by mass or less. The content of the component (B) in the oral composition of the present invention is 0.35% by mass or more and 1.3% by mass or less, preferably 0.44 to 1.1% by mass. , More preferably 0.46 to 0.85% by mass, still more preferably 0.48 to 0.7% by mass.

The mass ratio ((A) / (B)) of the fluorine atom equivalent amount of the component (A) to the content of the component (B) in the oral composition of the present invention is the fluorine ion of the component (A) and the component ( From the viewpoint of forming finely divided calcium fluoride particles composed of calcium ions released from B) on the tooth surface and the dentin tubules, effectively increasing the amount of fluorine ions adsorbed, and strengthening the dentin, it is preferable. It is 0.12 or more, more preferably 0.2 or more, still more preferably 0.23 or more, and even more preferably 0.26 or more. Further, the mass ratio ((A) / (B)) of the fluorine atom equivalent amount of the component (A) and the content of the component (B) in the oral composition of the present invention is preferably 0 from the same viewpoint. It is 8.8 or less, more preferably 0.6 or less, still more preferably 0.4 or less, still more preferably 0.35 or less. The mass ratio ((A) / (B)) of the fluorine atom equivalent amount of the component (A) to the content of the component (B) in the oral composition of the present invention is preferably 0.12 to 0. It is 8, more preferably 0.2 to 0.6, still more preferably 0.23 to 0.4, and even more preferably 0.26 to 0.35.

The oral composition of the present invention contains 0.5% by mass or more and 6% by mass or less of a fatty acid divalent metal salt derived from a saturated fatty acid having 12 or more and 18 or less carbon atoms as the component (C). As a result, in combination with the above components, the amount of fluorine ions taken up on the tooth surface and the dentin tubules is effectively and effectively increased to strengthen the dentin while exhibiting excellent sealing ability of the opening of the dentin tubules. Therefore, pain and the like due to hyperesthesia can be sufficiently suppressed.

The component (C) is a component composed of two saturated fatty acids and a divalent metal, and specific examples of the saturated fatty acids include lauric acid, myristic acid, pentadecic acid, palmitic acid, margaric acid, and margaric acid. One or more selected from stearic acid can be mentioned. Of these, lauric acid, myristic acid, and stearic acid are preferable, stearic acid is more preferable, and the two saturated fatty acids constituting the component (C) are preferably the same. Further, examples of the divalent metal include one or more selected from zinc, calcium, magnesium, strontium, and barium. Among them, one or more selected from zinc, calcium, and magnesium are preferable from the viewpoint of applicability into the oral cavity and ductility that contributes to the excellent sealing ability of the opening of the dentin capillary tube. Is more preferable.

The content of the component (C) causes finely divided calcium fluoride particles composed of the fluorine ion of the component (A) and the calcium ion released from the component (B) to be formed on the tooth surface and the dentin tubules. From the viewpoint of further enhancing the excellent sealing ability of the opening of the dentin tubule and enhancing the effect of suppressing pain and the like, 0.5% by mass or more, preferably 1 It is 1.5% by mass or more, more preferably 1.7% by mass or more, and further preferably 1.8% by mass or more. Further, the content of the component (C) does not inhibit the increase in the amount of fluorine ions adsorbed on the tooth surface and the dentin tubules due to the calcium fluoride particles atomized by the component (A) and the component (B). In the oral composition of the present invention, 6% by mass or less, from the viewpoint of effectively strengthening the dentin, and from the viewpoint of avoiding the appearance of unpleasant taste such as metallic taste and ensuring a good flavor of the composition. It is preferably 5% by mass or less, more preferably 4.5% by mass or less, and further preferably 4% by mass or less. The content of the component (C) in the oral composition of the present invention is 0.5% by mass or more and 6% by mass or less, preferably 1.5 to 5% by mass, more preferably. It is 1.7 to 4.5% by mass, more preferably 1.8 to 4% by mass.

The mass ratio ((A) / (C)) of the fluorine atom equivalent amount of the component (A) to the content of the component (C) in the oral composition of the present invention is the fluorine ion of the component (A) and the component ( From the viewpoint of forming finely divided calcium fluoride particles composed of calcium ions released from B) on the tooth surface and the dentin tubules, effectively increasing the amount of fluorine ions adsorbed, and strengthening the dentin, it is preferable. It is 0.01 or more, more preferably 0.02 or more, and further preferably 0.03 or more. Further, the mass ratio ((A) / (C)) of the fluorine atom equivalent amount of the component (A) and the content of the component (C) in the oral composition of the present invention is preferably 0 from the same viewpoint. It is 0.3 or less, more preferably 0.2 or less, still more preferably 0.15 or less. The mass ratio ((A) / (C)) of the fluorine atom equivalent amount of the component (A) to the content of the component (C) in the oral composition of the present invention is preferably 0.01 to 0. It is 3, more preferably 0.02 to 0.2, and even more preferably 0.03 to 0.15.

The mass ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) in the oral composition of the present invention suppresses the aggregation of the component (B) and the teeth. From the viewpoint of effectively and effectively increasing the adsorption of finely divided calcium fluoride particles and the amount of fluorine ion adsorption on the surface and into the dentin tubules to strengthen the dentin, 0.12 or more is preferable. It is 0.14 or more, more preferably 0.24 or more, and the mass ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) is a tooth. From the viewpoint of not unnecessarily reducing the amount of fluorine ions adsorbed on the surface and the dentin tubules and the ability to block the opening of the dentin tubules, it is 1.5 or less, preferably 1.0 or less, and more preferably 0. It is 6.6 or less, more preferably 0.35 or less. The mass ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) in the oral composition of the present invention is 0.12 or more and 1.5 or less. It is preferably 0.12 to 1.0, more preferably 0.14 to 0.6, and even more preferably 0.24 to 0.35.
This causes not only the progression of gingival inflammation and aging, but also the case where the dentin of the tooth is exposed due to the retraction of the gingiva and the damage of the enamel of the tooth due to improper brushing that applies an excessive load. The opening of the dentin tubule by the oral composition of the present invention under various wide-ranging usage environments including the occurrence of cracks and caries, as well as the occurrence of tooth fracture due to impact and the occurrence of wedge-shaped defects due to improper occlusion. It is possible to achieve both the effect of blocking the gingiva and the effect of effectively promoting remineralization and strengthening the gingiva, and it is possible to effectively suppress pain and the like due to hyperesthesia.

The oral composition of the present invention preferably contains one or more desensitizers (D) selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate. By containing such a component (D), it is possible to remove the nerve hypersensitivity or desensitize the nerve, and further enhance the effect of suppressing pain and the like caused by the ability to block the opening of the dentin tubule. can. Of these, potassium nitrate is preferable.

The content of the component (D) is preferably 1% by mass or more in the oral composition of the present invention from the viewpoint of further enhancing the effect of suppressing pain due to hypersensitivity in combination with the component (C). , More preferably 2% by mass or more, still more preferably 3% by mass or more. Further, the content of the component (D) is preferably 15% by mass or less, more preferably 10 in the oral composition of the present invention, from the viewpoint of the effect of suppressing pain due to hypersensitivity and economic efficiency. It is 0% by mass or less, more preferably 8% by mass or less.

In particular, when potassium nitrate is used as the component (D), the mass ratio ((C) / (potassium nitrate)) between the content of the component (C) and the content of potassium nitrate in the oral composition of the present invention is hypersensitivity. From the viewpoint of further enhancing the effect of suppressing pain due to the disease, it is preferably 0.3 or more, more preferably 0.4 or more, further preferably 0.5 or more, and preferably 1.0 or less. Yes, more preferably 0.9 or less, still more preferably 0.85 or less.

When the oral composition of the present invention is a toothpaste composition, it further contains an alkyl sulfate ester salt such as sodium lauryl sulfate, an N-acyl amino acid salt, an alkyl phosphate, a higher fatty acid sulfonated monoglyceride salt, and a fatty acid ester of isethionic acid. It preferably contains an anionic surfactant such as a salt, an N-long-chain acyltaurine sodium salt, and a polyoxyethylene monoalkyl phosphate. Among them, alkyl sulfate ester salts and N-long-chain acyl taurine sodium salts are given from the viewpoint of imparting good foaming and a feeling of use, and ensuring the retention of the composition in the oral cavity and the adsorptivity or adhesion to the tooth surface. Is more preferable, and it is further preferable to use them together.

More specifically, the content of the anionic surfactant in the oral composition of the present invention is preferably 0.2% by mass or more, more preferably 0.4% by mass or more, still more preferably. Is 0.6% by mass or more, preferably 1.5% by mass or less, more preferably 1.2% by mass or less, and further preferably 1% by mass or less.

Further, when the oral composition of the present invention contains an anionic surfactant, it suppresses salt exchange with potassium nitrate, secures retention and adhesion while providing good foam quality, and opens dentin tubules. From the viewpoint of effectively achieving both the effect of sealing the portion and the effect of promoting remineralization and strengthening the dentin, the alkylsulfate ester salt is preferably contained in a specific content.
More specifically, the content of the alkyl sulfate is preferably 1 to 50% by mass, more preferably 5 to 30% by mass or less, still more preferably 10 in the content of the anionic surfactant. It is ~ 20% by mass or less.

The oral composition of the present invention reinforces the development of good foaming and usability, further enhances the retention of the composition in the oral cavity and the adsorptivity or adhesion to the tooth surface, and opens the dentin capillary tube. It is preferable to contain a nonionic surfactant from the viewpoint of ensuring both the effect of blocking the tooth and the effect of promoting remineralization and strengthening the dentin. Specific examples of the nonionic surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, and alkyl glucoside. Examples thereof include polyglycerin fatty acid ester, polyoxyethylene monoalkyl (or alkenyl) ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkyl phenyl ether, fatty acid alkanolamide, and polyglycol. Of these, polyoxyethylene hydrogenated castor oil is preferable, and it is preferable to use it in combination with the above-mentioned anionic surfactant.
More specifically, the content of the nonionic surfactant is preferably 1% by mass or less, more preferably 0.8% by mass or less, and further preferably 0 in the oral composition of the present invention. It is 0.7% by mass or less, preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and further preferably 0.3% by mass or more. Further, the mass ratio (anionic surfactant / nonionic surfactant) between the content of the anionic surfactant and the content of the nonionic surfactant is preferably 1 to 2, more preferably 1 to 1.6. Is.

When the oral composition of the present invention is a dentifrice composition, a binder can be further contained. As such a binder, one or more selected from xanthan gum, sodium carboxymethyl cellulose, sodium alginate, carrageenan, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragant gum, Arabic gum, guar gum and the like can be used. Can be mentioned. Of these, xanthan gum and sodium carboxymethyl cellulose are preferable, and xanthan gum is more preferable.

The content of such a caking agent exhibits good foam quality and foam retention while maintaining an appropriate shape retention property, and secures the retention of the composition in the oral cavity and the adsorptivity or adhesion to the tooth surface. Therefore, from the viewpoint of effectively achieving both the effect of closing the opening of the dentin capillary and the effect of promoting remineralization and strengthening the dentin, it is preferable to limit the amount to an appropriate level. Specifically, the content of the binder is preferably 4% by mass or less, more preferably 3% by mass or less, and preferably 2% by mass or more in the oral composition of the present invention. .. When xanthan gum is used, the content of such xanthan gum in the oral composition of the present invention is preferably 0.5% by mass or less, more preferably 0.3% by mass or less, and preferably 0. .15% by mass or more.

Among such binders, while maintaining an appropriate shape-retaining property, it exhibits even better foam quality and foam retention, and exhibits the retention of the composition in the oral cavity and the adsorptivity or adhesion to the tooth surface. From the viewpoint of ensuring, it is preferable to contain thickening silica. Such thickening silica is silica having a large amount of oil absorption, and is different from the abrasive silica used as an abrasive. Generally, the viscous silica has an oil absorption amount of 200 to 400 mL / 100 g, and the abrasive silica has an oil absorption amount of 50 to 150 mL / 100 g. Here, the oil absorption amount indicates the amount of oil that silica can carry, and the measuring method is specified by the amount of oil in the boiled sardine absorbed by the method of JIS K5101-13-2 (established in 2004). Syricia, Syropure (manufactured by Fuji Silysia Chemical Ltd.), Tixosyl (manufactured by Rhodia), Sorbosil (manufactured by Ineos Silica), Fineseal (manufactured by Tokuyama), Nipgel (manufactured by Tosoh Silica) Commercially available products can be used.
More specifically, the content of the thickening silica is preferably 1 to 10% by mass, more preferably 2 to 8% by mass, still more preferably 3 to 3 to 10% by mass in the oral composition of the present invention. It is 6% by mass.

The oral composition of the present invention further effectively refines the calcium fluoride particles formed by the component (A) and the component (B), and does not impair the sealing ability of the opening of the dentin tubule. From the viewpoint of increasing the amount of fluorine adsorbed on the surface, it is preferable to further contain xylitol. The content of such xylitol in the oral composition of the present invention is preferably 3% by mass or more, more preferably 8% by mass or more, preferably 25% by mass or less, and more preferably 20% by mass. % Or less.

The oral composition of the present invention preferably limits the content of fatty acids from the viewpoint of suppressing the inhibition of the formation of fine calcium fluoride particles by the components (A) and (B). Examples of such fatty acids include those having a hydrocarbon group having 18 or less carbon atoms, more preferably 16 or less carbon atoms, and preferably 12 or more carbon atoms. Specific examples thereof include lauric acid, myristic acid, palmitic acid, stearic acid and the like.
The content of such fatty acid in the oral composition of the present invention is preferably 0.3% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less. Yes, or the oral composition of the present invention preferably does not contain fatty acids.

The oral composition of the present invention does not inhibit the inhibitory effect of pain and the like due to hypersensitivity, and provides a good usability while eliminating as much as possible the factors that induce the onset of new pain and the like, and is good. From the viewpoint of retaining foaming and ensuring adsorptivity and adhesion, it is preferable to limit the content of the abrasive. Specific examples of such an abrasive include abrasive silica, calcium dibasic phosphate monohydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum oxide, aluminum hydroxide, magnesium acetate, and magnesium dibasic phosphate. , One or more selected from tertiary magnesium phosphate, zeolite and the like.
The content of such an abrasive is preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 4% by mass or less in the oral composition of the present invention.

The oral composition of the present invention contains water. Such water includes not only purified water and the like blended in the oral composition, but also water contained in each blended component, such as a 70% sorbitol solution (aqueous solution) used for prescribing, for the oral cavity. It means the total water content contained in the composition. By containing such water, the component (A) and the component (B) can be satisfactorily dissolved or dispersed to form more effectively finely divided calcium fluoride particles on the tooth surface, which is a desired effect. Can be fully exerted.

For example, when the oral composition of the present invention is a toothpaste composition, the content of water in the oral composition of the present invention is preferably 5% by mass or more, more preferably 15% by mass or more. Yes, preferably 95% by mass or less, and more preferably 80% by mass or less. The content of water in the oral composition of the present invention is preferably 5 to 95% by mass, more preferably 15 to 80% by mass.
In this case, the water content can be calculated from the blended water content and the water content in the blended components, but can be measured by, for example, a Karl Fischer titer. As the Karl Fischer Moisture Meter, for example, a trace moisture measuring device (Hiranuma Sangyo Co., Ltd.) can be used. In this device, 5 g of the oral composition is taken, suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension can be dispensed to measure the water content.

When the oral composition of the present invention is a liquid oral composition, the content of water in the oral composition of the present invention is preferably 8% by mass or more, more preferably 10% by mass. The above is more preferably 12% by mass or more, preferably 50% by mass or less, more preferably 45% by mass or less, still more preferably 40% by mass or less. The content of water in the oral composition of the present invention is preferably 8 to 50% by mass, more preferably 10 to 45% by mass, and further preferably 12 to 40% by mass.

The oral composition of the present invention further comprises a cationic surfactant; a monofluorophosphate ion supply compound such as sodium monofluorophosphate and potassium monofluorophosphate; glycerin and polyethylene, as long as the effects of the present invention are not impaired. Glycols, wetting agents and sweeteners; sugar alcohols other than xylitol such as sorbitol; pH adjusters such as sodium hydrogen phosphate; fragrances; quaternary ammonium compounds, biguanide compounds, isopropylmethylphenol, triclosan, timole, and β- It can contain medicinal ingredients such as glycyrrhetinic acid and other active ingredients; fragrances; pigments and the like.
When the oral composition of the present invention is a dentifrice composition, it preferably contains propylene glycol from the viewpoint of increasing the amount of fluorine adsorbed on the tooth surface. The content of propylene glycol in the oral composition of the present invention is preferably 1 to 20% by mass, more preferably 5 to 15% by mass.

When the oral composition of the present invention is a toothpaste composition, the viscosity of the oral composition at 25 ° C. is such that the composition stays in the oral cavity and is adsorbed on the tooth surface while maintaining an appropriate shape retention. From the viewpoint of effectively achieving both the effect of closing the opening of the dentin capillary and the effect of promoting remineralization and strengthening the dentin by ensuring the property or adhesion, the value is preferably 1500 dPa · s or more. Yes, more preferably 2000 dPa · s or more, further preferably 2300 dPa · s or more, preferably 3500 dPa · s or less, more preferably 3000 dPa · s or less, still more preferably 2700 dPa · s or less. ..
The viscosity at 25 ° C. means a value measured using a helipas-type viscometer, and specifically, a viscosity of an oral composition that has been allowed to stand at room temperature (25 ° C.) for at least 24 hours after production. After packing in a container for measurement and storing in a thermostat at 25 ° C for 24 hours, using a helipas type viscometer (VISCOMETER TVB-10 Toki Sangyo), 25 ° C, rotor TC, rotation speed 2.5 rpm, It can be measured under the condition of 1 minute.

When the oral composition of the present invention is a toothpaste composition, the rotational viscosity of the oral composition at 25 ° C. using a cylindrical rotor is preferably 2500 dPa · s or more from the same viewpoint. , More preferably 3000 dPa · s or more, further preferably 3300 dPa · s or more, preferably 4500 dPa · s or less, more preferably 4000 dPa · s or less, still more preferably 3700 dPa · s or less.
The rotational viscosity using a cylindrical rotor at 25 ° C is measured under the conditions of 25 ° C, B8H type viscometer (Toki Sangyo TVB-10R), rotor H7, rotational speed 2.5 rpm, and 1 minute. Means a value. The rotor H7 has a cylindrical shape and has a region in which a part of the cylindrical shape has a small diameter, and is different in shape from a rotor having a disk shape for measuring a liquid or gel-like composition. .. The rotational viscosity using the above-mentioned cylindrical rotor is a value measured in consideration of viscosity, hardness, degree of elongation, etc., and is compared to the helipus viscosity to the teeth and gingiva of the oral composition. It is considered that it is suitable as an index for evaluation according to the adhesiveness of.

In the case of the liquid oral composition, the method for applying the oral composition of the present invention to the oral cavity may be used by including it in the oral cavity and sufficiently spreading it in the oral cavity, and then taking it out of the mouth. When the oral composition of the present invention is a dentifrice composition, it may be applied or brushed with a toothbrush. Further, from the viewpoint of sufficiently exerting the effect of blocking the opening of the dentin tubule and the effect of promoting remineralization and strengthening the dentin, and effectively suppressing pain due to hypersensitivity, the oral cavity of the present invention. The frequency of use of the composition is preferably 1 to 5 times a day, and it is preferable to continue this for 1 day or more or 1 to 2 weeks in a month.

With respect to the embodiments described above, the present invention further discloses the following oral compositions.
[1] The following components (A) to (C):
(A) One or two fluorine ion supply compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass or more and 1.3% by mass or less (C) Carbon number 12 or more and 18 or less Fatty acid divalent metal salt derived from saturated fatty acid of No. 1.5% by mass or more and 6% by mass or less, and the mass ratio of the content of the component (B) to the content of the component (C) ((B)) / (C)) is an oral composition of 0.12 or more and 1.5 or less.
[2] The content of the component (A) is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.15% by mass or more, and even more preferably. Is 0.25% by mass or more, preferably 1% by mass or less, more preferably 0.8% by mass or less, still more preferably 0.5% by mass or less, still more preferably 0.4. The oral composition according to the above [1], which is by mass or less.
[3] The fluorine atom equivalent amount of the component (A) is preferably 0.005% by mass or more, more preferably 0.05% by mass or more, and further preferably 0.07% by mass or more. Even more preferably 0.11% by mass or more, preferably 0.4% by mass or less, still more preferably 0.35% by mass or less, still more preferably 0.25% by mass or less, still more. The oral composition according to the above [1] or [2], preferably 0.2% by mass or less.
[4] The content of the component (B) is preferably 0.44% by mass or more, more preferably 0.46% by mass or more, still more preferably 0.48% by mass or more, and preferably 1 . The oral composition according to any one of the above [1] to [3], which is 1% by mass or less, more preferably 0.85% by mass or less, still more preferably 0.7% by mass or less.
[5] The mass ratio ((A) / (B)) of the fluorine atom equivalent amount of the component (A) to the content of the component (B) is preferably 0.12 or more, more preferably 0.2. The above, more preferably 0.23 or more, still more preferably 0.26 or more, preferably 0.8 or less, still more preferably 0.6 or less, still more preferably 0.4. The oral composition according to any one of the above [1] to [4], which is the following, more preferably 0.35 or less.

[6] The saturated fatty acid constituting the component (C) is preferably one or more selected from lauric acid, myristic acid, pentadecylic acid, palmitic acid, margaric acid, and stearic acid, and more preferably lauric acid. The oral composition according to any one of the above [1] to [5], which is an acid, myristic acid, stearic acid, and more preferably stearic acid.
[7] The divalent metal constituting the component (C) is one or more selected from zinc, calcium, magnesium, strontium, and barium, and preferably one selected from zinc, calcium, and magnesium. Alternatively, the oral composition according to any one of the above [1] to [6], which is two or more, more preferably zinc.
[8] The content of the component (C) is preferably 1.5% by mass or more, more preferably 1.7% by mass or more, still more preferably 1.8% by mass or more, and preferably 5 The oral composition according to any one of the above [1] to [7], which is 1% by mass or less, more preferably 4.5% by mass or less, still more preferably 4% by mass or less.
[9] The mass ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) is preferably 0.14 or more, more preferably 0.24 or more. The oral composition according to any one of the above [1] to [8], preferably 1.0 or less, more preferably 0.6 or less, and further preferably 0.35 or less.
[10] The mass ratio ((A) / (C)) of the fluorine atom equivalent amount of the component (A) to the content of the component (C) is preferably 0.01 or more, more preferably 0.02. The above, more preferably 0.03 or more, preferably 0.3 or less, more preferably 0.2 or less, still more preferably 0.15 or less, the above [1] to [9]. The oral composition of any one.
[11] For the oral cavity of any one of the above [1] to [10], which further contains one or more desensitizing agents (D) selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate. Composition.
[12] The oral composition according to the above [11], wherein the content of the component (D) is preferably 15% by mass or less, more preferably 10% by mass or less, and further preferably 8% by mass or less.
[13] Potassium nitrate is contained as the component (D), and the mass ratio ((C) / (potassium nitrate)) of the content of the component (C) to the content of potassium nitrate is preferably 0.3 or more. More preferably 0.4 or more, still more preferably 0.5 or more, preferably 1.0 or less, still more preferably 0.9 or less, still more preferably 0.85 or less. 1]-[12] The oral composition according to any one.

[14] The content of the nonionic surfactant is preferably 1% by mass or less, more preferably 0.8% by mass or less, still more preferably 0.7% by mass or less, and preferably 0.1 by mass. The oral composition according to any one of the above [1] to [13], which is 1% by mass or more, more preferably 0.2% by mass or more, and further preferably 0.3% by mass or more.
[15] Contains xylitol, and the content thereof is preferably 3% by mass or more, more preferably 8% by mass or more, preferably 25% by mass or less, and more preferably 20% by mass or less. The oral composition according to any one of the above [1] to [14].
[16] The fatty acid content is preferably 0.3% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, or no fatty acid. The oral composition according to any one of [1] to [15].

[17] The oral composition according to any one of the above [1] to [16], which is a liquid oral composition.
[18] The content of water is preferably 8% by mass or more, more preferably 10% by mass or more, further preferably 12% by mass or more, preferably 50% by mass or less, and more preferably. The oral composition according to the above [17], which is 45% by mass or less, more preferably 40% by mass or less.

[19] The oral composition according to any one of the above [1] to [16], which is a toothpaste composition.
[20] The content of the anionic surfactant is preferably 0.2% by mass or more, more preferably 0.4% by mass or more, still more preferably 0.6% by mass or more, and preferably 1 It is 5.5% by mass or less, more preferably 1.2% by mass or less, still more preferably 1% by mass or less, and the content of the alkyl sulfate is preferably in the content of the anionic surfactant. Is 1 to 50% by mass, more preferably 5 to 30% by mass or less, still more preferably 10 to 20% by mass or less, the oral composition according to the above [19].
[21] The above [19] or [20], which contains a binder and has a content of preferably 4% by mass or less, more preferably 3% by mass or less, and preferably 2% by mass or more. Oral composition.
[22] The binder is preferably one or two selected from xanthan gum, sodium carboxymethyl cellulose, sodium alginate, carrageenan, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragant gum, Arabic gum, guar gum and the like. The oral composition according to the above [21], which is more than a seed, more preferably xanthan gum, sodium carboxymethyl cellulose, and even more preferably xanthan gum.
[23] The content of the thickening silica is preferably 1 to 10% by mass, more preferably 2 to 8% by mass, and further preferably 3 to 6% by mass, as described above [19] to [22]. The oral composition of any one.
[24] The content of water is preferably 5% by mass or more, more preferably 15% by mass or more, preferably 95% by mass or less, and more preferably 80% by mass or less [19]. -[23] The oral composition according to any one.
[25] The oral composition according to any one of the above [19] to [24], which contains propylene glycol and has a content of preferably 1 to 20% by mass, more preferably 5 to 15% by mass. ..
[26] The viscosity at 25 ° C. is preferably 1500 dPa · s or more, more preferably 2000 dPa · s or more, further preferably 2300 dPa · s or more, preferably 3500 dPa · s or less, and more preferably. The oral composition according to any one of the above [19] to [25], which is 3000 dPa · s or less, more preferably 2700 dPa · s or less.

[27] Use of the oral composition according to any one of the above [1] to [26] for closing the opening of the dentin capillary tube.
[28] Use of the oral composition according to any one of the above [1] to [26] for strengthening the tooth structure.
[29] A method for closing an opening of a dentin capillary tube, wherein the oral composition according to any one of the above [1] to [26] is applied to a tooth.

[30] The oral composition of the present invention has the following components (A) to (C): from the viewpoint of effectively increasing the adsorption rate of fluorine ions on the tooth surface and the dentin capillary tube.
(A) One or two fluorine ion supply compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass or more and 1.3% by mass or less (C) Carbon number 12 or more and 18 or less Fatty acid divalent metal salt derived from saturated fatty acid of No. 0.5% by mass or more and 6% by mass or less, and the mass ratio of the fluorine atom equivalent amount of the component (A) to the content of the component (B) ((() A) / (B)) is 0.12 or more and 0.8 or less, and the mass ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) is 0. Most preferably, it is 14 or more and 0.6 or less.

Hereinafter, the present invention will be specifically described based on examples. Unless otherwise specified in the table, the content of each component indicates mass%.

[Examples 1 to 7, Comparative Examples 1 to 8]
According to the formulation shown in Table 1, predetermined components were mixed by a conventional method to prepare each liquid oral composition.
Then, using the obtained liquid oral composition, the fluorine ion uptake rate on the HAP surface was determined according to the following method.
The results are shown in Table 1.

<< Fluorine ion uptake rate on the surface of HAP >>
HAP pellets (APP-100 HOYA) 10 mm × 10 mm × 2 mm were immersed in 20 mL of a 4-fold diluted solution of the obtained liquid oral composition and immersed for 3 minutes, and then the liquid oral composition was removed with ion-exchanged water. The pellet was dried. Fluorine ions are extracted from the dried pellets with 1N hydrochloric acid for 30 seconds, and HAP is used with a fluorine ion electrode (ionplus20Fluoride (manufactured by ORION)) and an ion analyzer (Expandable ionAnalyzer EA 940 (manufactured by ORION)). The amount of fluorine adsorbed on the pellet was regarded as the amount of fluorine ion uptake and quantified.
Based on the fluorine atom equivalent amount of the component (A) used when preparing each liquid oral composition as a standard, the fluorine ion uptake rate on the HAP surface (based on the obtained fluorine ion uptake amount value) %) Was calculated. The larger the value, the larger the amount of fluorine ion uptake, indicating that the dentin is excellently strengthened.

[Examples 8 to 10, Comparative Examples 9 to 12]
According to the formulation shown in Table 2, each toothpaste composition was prepared by mixing predetermined components by a conventional method.
Then, using the obtained toothpaste composition, measurement and evaluation were performed according to the following method.
The results are shown in Table 2.

《Measurement of helipus viscosity》
A toothpaste composition that has been allowed to stand at room temperature (25 ° C) for 24 hours after production is packed in a container for viscosity measurement, stored in a thermostat at 25 ° C for 24 hours, and then a helipas-type viscometer (VISCOMETER TVB-10 Toki Sangyo). The measurement was performed under the conditions of rotor TC, rotation speed 2.5 rpm, and 1 minute.

<< Measurement of B8H viscosity >>
The rotational viscosity of the obtained toothpaste composition was measured under the conditions of a B8H type viscometer (Toki Sangyo TVB-10R), a rotor H7, a rotational speed of 2.5 rpm, and 1 minute.

<< Fluorine ion uptake rate on the surface of HAP >>
2.5 g of the obtained toothpaste composition was diluted 4-fold with ion-exchanged water to obtain 10 g of each sample. Then, HAP pellets (APP-100 HOYA) 10 mm × 10 mm × 2 mm were immersed in a 4-fold diluted solution of each sample for 3 minutes, and then the toothpaste composition was removed with ion-exchanged water to dry the pellets. Fluorine ions are extracted from the dried pellets with 1N hydrochloric acid for 30 seconds, and HAP is used with a fluorine ion electrode (ionplus20Fluoride (manufactured by ORION)) and an ion analyzer (Expandable ionAnalyzer EA 940 (manufactured by ORION)). The amount of fluorine adsorbed on the pellet was regarded as the amount of fluorine ion uptake and quantified.
Based on the fluorine atom equivalent amount of the component (A) used when preparing each toothpaste composition as a standard, the fluorine ion uptake rate (%) on the HAP surface based on the obtained fluorine ion uptake amount value. Was calculated. The larger the value, the larger the amount of fluorine ion uptake, indicating that the dentin is excellently strengthened.

<< Evaluation of pain improvement caused by hypersensitivity >>
The obtained dentifrice composition was evaluated for the degree of pain prevention or suppression due to dentin hypersensitivity symptoms due to long-term use. As evaluation subjects (panelists), those who have had their teeth squeezed daily in the last month, or those who have had their teeth squeezed at least once a week were selected. Eighty-five panelists evaluated whether the pain caused by hypersensitivity was prevented or suppressed after using each toothpaste composition 2-3 times a day for 2 weeks.
The evaluation criteria are "1: soft", "2: no change", and "3: increased pain" for the "improvement effect of squeaky pain" after 2 weeks of continuous use. After receiving the answers from, the total number of panelists at each stage was calculated, and the ratio among the total panelists was calculated. Next, the percentage of panelists who answered "1: Soft" was set to 100%, and the value quantified by replacing this with 10 was used as an index for evaluating pain caused by hyperesthesia.
The results are shown in Table 2. The larger the value, the stronger the tooth substance by the use of the dentifrice composition, and the more the pain caused by the hypersensitivity was prevented or suppressed.

《Observation evaluation of dentin canaliculus》
About 1 cm square sections (thickness about 500 μm) of bovine dentin were mirror-polished with sandpaper and sonicated for 10 minutes. Next, the 1% aqueous citric acid solution was etched for 20 seconds and then sonicated again for 10 minutes to completely remove the smear layer. Next, a toothpaste 4-fold diluted solution was prepared using the toothpaste composition obtained in Example 8, and brushing was performed once for 5 minutes under a weight of 200 g. The state of the dentin capillary tube before and after using the toothpaste composition was observed using SEM (VE-7800 manufactured by EYENCE, acceleration voltage: 2.0 kV) (state on the outermost surface at low acceleration voltage). Observe only). A photograph of the opening of the dentin tubule before use is shown in FIG. 1, and a photograph of the opening of the dentin tubule after use is shown in FIG.
From FIG. 2, it was confirmed that by applying the toothpaste composition of the present invention, the opening of the dentin tubule shown in FIG. 1 can be effectively closed.

Claims (8)

The following components (A) to (C):
(A) One or two fluorine ion supply compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass or more and 1.3% by mass or less (C) Carbon number 12 or more and 18 or less Fatty acid divalent metal salt derived from saturated fatty acid of No. 0.5% by mass or more and 6% by mass or less, and the mass ratio of the content of the component (B) to the content of the component (C) ((B)) / (C)) is an oral composition of 0.14 or more and 1.5 or less. The oral composition according to claim 1, which contains one or more desensitizing agents (D) selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate. The invention according to claim 1 or 2, wherein the mass ratio ((A) / (B)) of the fluorine atom equivalent amount of the component (A) to the content of the component (B) is 0.12 or more and 0.8 or less. Oral composition. Any of claims 1 to 3 in which the mass ratio ((A) / (C)) of the fluorine atom equivalent amount of the component (A) to the content of the component (C) is 0.01 or more and 0.3 or less. The oral composition according to item 1. The oral composition according to any one of claims 1 to 4, which further contains propylene glycol and is a toothpaste composition. The oral composition according to claim 5, further containing 0.2% by mass or more and 3% by mass or less of an anionic surfactant. The oral composition according to claim 5 or 6, further containing 2% by mass or more and 4% by mass or less of a binder. The oral composition according to claim 6 or 7, wherein the content of the alkyl sulfate is 1% by mass or more and 50% by mass or less in the content of the anionic surfactant.

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