JP6038567B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition.

  Dentine hypersensitivity is a disease in which pain is induced when a mechanical, thermal or chemical stimulus is applied to the tooth surface. The progression of periodontitis, aging, strong dentifrice treatment, etc. cause gingival retraction and tooth enamel damage, and this is due to the exposure of the dentin of the covered tooth. Conventionally, various proposals have been made to prevent or treat such dentin hypersensitivity.

  For example, Patent Document 1 discloses a method of applying an effective amount of a potassium salt selected from potassium bicarbonate and potassium chloride, and the activity of the sensory nerve itself is reduced by the action of potassium ions. It relieves pain. Patent Document 2 discloses soluble potassium salts such as potassium nitrate as well as soluble stannous salts and soluble strontium salts such as strontium chloride as active ingredients capable of reducing the sensitivity of dentin. ing. Furthermore, Patent Document 3 describes that when an oral care maintenance composition is applied to the oral cavity by brushing, tooth sensitivity can be reduced by a free or salt-form basic amino acid contained in the composition. ing.

  On the other hand, promoting remineralization to return the teeth to their original healthy state can also contribute to suppressing the onset of dentine hypersensitivity. For example, Patent Document 4 discloses an oral composition containing, as a remineralization component, a fluorine compound and a poorly water-soluble zinc compound such as zinc oxide, zinc citrate, and zinc stearate.

  On the other hand, the onset mechanism of hypersensitivity of the dentin is the hydrodynamic theory, that is, the dentinal tubule opens on the exposed surface of the dentin, and external stimuli are transmitted from this opening to the tissue fluid in the dentinal tubule. The theory that the flow of tissue fluid reaches the pulpal nerve located at the innermost end in the tubule and pain is perceived is supported. Based on such theory, in order to suppress the onset of dentine hypersensitivity, for example, Patent Document 5 discloses a perception separated into a first liquid containing an aluminum compound and an auxiliary containing a phosphate compound. An application agent for hypersensitivity has been disclosed, and an attempt has been made to physically block the opening of the dentinal tubule by depositing an aluminum salt by a reaction between the first liquid and the auxiliary agent. Moreover, the agent for preventing and treating dentine hypersensitivity disclosed in Patent Document 6 is an oral cavity disclosed in Patent Document 4 by a colloid formed by a reaction between a metal salt such as aluminum lactate and a polyol phosphate. As with the composition for use, the opening of the dentinal tubule is blocked.

JP-T 61-501389 JP 2000-281551 A Special table 2011-510981 gazette Japanese Patent Laid-Open No. 2000-247852 JP-A-6-116153 JP-A-5-117157

  However, the component that decreases the activity of sensory nerves described in Patent Document 1 or 2 changes the ion balance around the sensory nerves and makes the nerves insensitive, so that not only pain can not be reduced sufficiently, but also pain is reduced. It lacks immediate effect and sustainability. Moreover, since remineralization brought about by the oral composition described in Patent Document 4 is a mild action, it is difficult to immediately suppress the onset of dentin hypersensitivity and to maintain the effect.

  Based on the hydrodynamic theory, it is considered effective to prevent the flow of tissue fluid in the dentinal tubule by blocking the opening of the dentinal tubule based on the hydrodynamic theory. It is done. However, as in Patent Document 3, it is difficult to sufficiently seal the opening of the dentinal tubule only by using a basic amino acid, and the effect of reducing pain due to hypersensitivity of the dentin is lacking. Further, Patent Document 5 attempts to seal the opening of the dentinal tubule by forming an aluminum lactate salt, but it is necessary to deposit this salt around the opening of the dentinal tubule. Since it is difficult to sufficiently seal the opening of the dentinal tubule even with the colloid described in Patent Document 6, any of the agents described in any of the above documents causes pain caused by dentin visual hypersensitivity. It lacks the immediate effect of reducing, and lacks the effect of sufficiently reducing pain.

  Accordingly, the present invention relates to a composition for oral cavity that effectively and sufficiently seals an opening of a dentinal tubule on the surface of an exposed dentin to effectively prevent pain caused by dentinal hypersensitivity.

  Therefore, the present inventor uses a fatty acid having a specific alkyl group and a basic amino acid together with water at a specific molar ratio to make a specific pH range, thereby opening an opening of the dentinal tubule on the exposed dentin surface. It has been found that a composition for oral cavity can be obtained that can quickly and sufficiently block and effectively prevent pain caused by dentine hypersensitivity.

That is, the present invention includes the following components (A), (B), and (C):
(A) Fatty acid having a hydrocarbon group having 12 to 18 carbon atoms (B) A basic amino acid, and (C) A molar concentration of component (B) in terms of free basic amino acid and component (A) It is related with the composition for oral cavity whose molar ratio ((B) / (A)) with respect to the molar concentration of free fatty acid conversion is 1-37, and pH is 6-9.2.

According to the composition for oral cavity of this invention, the opening part of the dentinal tubule in the surface of the exposed dentin can be sealed immediately and sufficiently. In addition, it is possible to cover the opening of the dentinal tubule without necessarily applying an external load such as brushing, and it is possible to effectively prevent pain due to hypersensitivity of the dentin.
Therefore, liquid oral compositions such as liquid dentifrices, mouth washes and mouth fresheners, toothpaste compositions, and oral compositions having other dosage forms for preventing or improving dentin hypersensitivity Can be used widely.

FIG. 1 is a microscope photograph of the surface of dentin when the oral composition of Example 1 is used. FIG. 2 is a microscope photograph of the surface of dentin when the oral composition of Example 2 was used. FIG. 3 is a microscope photograph of the surface of dentin when the composition for oral cavity of Comparative Example 1 is used. FIG. 4 is a microscope photograph of the surface of dentin when the oral composition of Example 10 was used.

Hereinafter, the present invention will be described in detail.
The composition for oral cavity of this invention contains the fatty acid (A) which has a C12-C18 hydrocarbon group, liquid oral compositions, such as a liquid dentifrice, a mouthwash, and a mouth freshener, toothpaste composition And other dosage forms. Such a component (A) forms a basic amino acid salt of a fatty acid that can exhibit good solubility in the oral composition of the present invention, at least a part of which together with the basic amino acid of the component (B) described later. It is preferable that almost all the component (A) forms a basic amino acid salt of a fatty acid together with the component (B). Therefore, the basic amino acid salt of the fatty acid can be sufficiently distributed to every corner of the oral cavity while being dissolved in the oral composition, and can easily reach the surface of the desired dentin. Also, when the basic amino acid salt of the fatty acid reaches the tooth surface, the basic amino acid salt of the fatty acid or the fatty acid precipitates and adheres firmly to the tooth surface, so the opening of the dentinal tubule is firmly Blocking can effectively prevent pain caused by dentine hypersensitivity. In addition, since fatty acids and basic amino acid salts of fatty acids are acid-resistant, it prevents the opening of dentinal tubules from being blocked by acidic beverages and foods, and suppresses pain caused by dentin hypersensitivity The effect can be sustained. Of the component (A) and component (B), the remaining component (A) and component (B) other than those forming the basic amino acid salt of fatty acid are released in the oral composition of the present invention. It exists as a fatty acid or free basic amino acid. That is, the composition for oral cavity of the present invention contains components (A) and (B), or salts of components (A) and (B).

  Carbon number of the hydrocarbon group which component (A) has is 18 or less from the viewpoint that the basic amino acid salt of the fatty acid formed with component (B) has a Kraft point in an appropriate temperature range and maintains good solubility. Is preferable, and 16 or less is more preferable, and 12 or more is preferable from the viewpoint of flavor and aftertaste when the composition is used. Examples of the hydrocarbon group include a saturated hydrocarbon group, an unsaturated hydrocarbon group, a linear hydrocarbon group, and a branched hydrocarbon group. A saturated hydrocarbon group is preferred, and a linear saturated hydrocarbon group is preferred. More preferred. Examples of such hydrocarbon groups include lauric acid, myristic acid, pentadecylic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, and the like. Lauric acid, myristic acid, pentadecylic acid, palmitic acid Acid is preferred. These may be used singly or in combination of two or more. In addition, lauric acid and myristic acid are preferable from the viewpoint of solubility of the basic amino acid salt of fatty acid in water, and palmitic acid is preferable from the viewpoint of improving the flavor.

In the oral composition of the present invention, at least a part of the component (A) is present as a basic amino acid salt of a fatty acid together with the component (B) in the oral composition of the present invention. The content of component (A) is expressed as a free fatty acid equivalent.
The content of component (A) is such that when the oral composition of the present invention is a liquid oral composition such as a liquid dentifrice, a mouthwash, and a mouth freshener, the feeling of use, solubility, and opening of the dentinal tubule From the viewpoint of sealing properties, it is preferably 0.02% by mass or more, more preferably 0.05% by mass or more, and 0.1% by mass in terms of free fatty acid in the oral composition of the present invention. More preferably, it is the above. When the oral composition of the present invention is a liquid oral composition such as a liquid dentifrice, a mouthwash, and a mouth freshener, the content of the component (A) is a free fatty acid from the viewpoint of usability and solubility. It is preferably 1% by mass or less in terms of conversion, more preferably 0.7% by mass or less, and further preferably 0.5% by mass or less from the viewpoint of storage stability and flavor.

  In addition, when the oral composition of the present invention is a toothpaste composition, the content of the component (A) is in the oral composition of the present invention from the viewpoint of feeling of use and opening of dentinal tubules. , Preferably 1.5% by mass or less in terms of free fatty acid, from the viewpoint of flavor, preferably 1.2% by mass or less, more preferably 1.0% by mass or less, 0.8 More preferably, it is at most mass%. When the oral composition of the present invention is a toothpaste composition, the content of the component (A) is determined in terms of free fatty acid in the oral composition of the present invention from the viewpoint of the ability to seal the opening of the dentinal tubule. The content is preferably 0.15% by mass or more, more preferably 0.2% by mass or more, and further preferably 0.25% by mass or more.

  The composition for oral cavity of the present invention contains a basic amino acid (B). Such a component (B) can impart good solubility while providing an effect of lowering the Kraft point of the basic amino acid salt of the fatty acid formed with the component (A) in the oral composition. Moreover, when reaching the surface of the dentin, the basic amino acid salt of the fatty acid can be effectively precipitated to cover the dentin surface, and the opening of the dentinal tubule can be sufficiently sealed.

  Examples of the component (B) include arginine and lysine. One of them may be used alone, or both may be used in combination. Among these, arginine is preferable from the viewpoint of lowering the craft point and flavor.

In the composition for oral cavity of the present invention, component (B) is present in the composition for oral cavity of the present invention because at least a part of component (B) is present as a basic amino acid salt of fatty acid together with component (A). The content of component (B) is expressed as a free base equivalent.
When the oral composition of the present invention is a liquid oral composition such as a liquid dentifrice, a mouthwash, and a mouth freshener, the content of the component (B) is such that the feeling of use and the opening of the dentinal tubules are sealed. From the point, in the composition for oral cavity of the present invention, it is preferably 0.02% by mass or more in terms of free basic amino acid, more preferably 0.05% by mass or more, and 0.1% by mass or more. It is more preferable that it is 0.2 mass% or more. When the oral composition of the present invention is a liquid oral composition, the content of the component (B) is preferably 2% by mass or less in terms of free basic amino acid from the viewpoint of storage stability. More preferably, it is 0.5 mass% or less, More preferably, it is 1 mass% or less, More preferably, it is 0.8 mass% or less.

  When the oral composition of the present invention is a toothpaste composition, the content of the component (B) is a free basic amino acid in the oral composition of the present invention from the viewpoint of sealing the opening of the dentinal tubule. In terms of conversion, it is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, further preferably 0.2% by mass or more, and free from the viewpoint of storage stability and flavor. It is preferably 2% by mass or less in terms of basic amino acid, more preferably 1.5% by mass or less, further preferably 1% by mass or less, and more preferably 0.8% by mass or less. Further preferred.

  In the oral composition of the present invention, the molar ratio ((B) / (A)) of the molar concentration of the component (B) in terms of free basic amino acid and the molar concentration of the component (A) in terms of free fatty acid is (S). From the viewpoint of efficiently forming a basic amino acid salt of a high fatty acid, from the viewpoint of improving the sealing performance of the opening of the dentinal tubule, from the viewpoint of maintaining an appropriate pH, good flavor and feeling of use, and storage stability 1 or more, preferably greater than 1, preferably 1.1 or more, more preferably 1.15 or more, more preferably 1.2 or more, 37 or less, preferably 15 or less, 7 or less Is more preferable, and 3 or less is more preferable.

  Component (A) and component (B) have the above molar ratios, and at least some of them together form a basic amino acid salt of a fatty acid. Therefore, the greater the difference between the molar concentration of component (B) and the molar concentration of component (A), the more free base of component (B) will be present, but the color of the oral composition after storage From the viewpoint of suppressing the change of the above and maintaining a good appearance, it is preferable that the difference between the molar concentration of the component (B) and the molar concentration of the component (A) is small. From this viewpoint, the difference ((B)-(A)) between the molar concentration of component (B) and the molar concentration of component (A) is preferably 100 mol / kg or less, more preferably 40 mol / kg. Or less, more preferably 20 mol / kg or less, and further preferably 15 mol / kg or less. The difference between the molar concentration of component (B) and the molar concentration of component (A) ((B)-(A)) is preferably from the viewpoint that component (A) sufficiently forms a basic amino acid salt of a fatty acid. 0 mol / kg or more, preferably greater than 0 mol / kg, more preferably 0.1 mol / kg or more, still more preferably 0.5 mol / kg or more, and even more preferably 1 mol / kg. kg or more. The difference ((B)-(A)) between the molar amount of component (B) and the molar amount of component (A) is preferably 0 to 100 mol / kg, more preferably 0.1 to 40. Mol / kg, more preferably 1 to 20 mol / kg, still more preferably 1 to 15 mol / kg. The molar concentration in the present invention is a molar molar concentration, which is the amount of substance (mole) of the component per 1 kg of the composition.

  The composition for oral cavity of the present invention contains water (C). This makes it possible to form basic amino acid salts of the fatty acids of the component (A) and the component (B) and dissolve them satisfactorily while fully dissolving them. Or it becomes possible to cover with the basic amino acid salt of a fatty acid, and the opening part sealing property of a dentinal tubule can be improved. From this viewpoint, when the oral composition of the present invention is a liquid oral composition such as a liquid dentifrice, a mouthwash, and a mouth freshener, the content of water (C) is the oral composition of the present invention. Preferably, it is 70 mass% or more, More preferably, it is 80 mass% or more, Preferably it is 95 mass% or less, More preferably, it is 90 mass% or less. When the oral composition of the present invention is a toothpaste composition, the content of water (C) is preferably 8% by mass or more, more preferably 10 in the oral composition of the present invention. It is at least mass%, more preferably at least 12 mass%, preferably at most 55 mass%, more preferably at most 45 mass%, still more preferably at most 40 mass%.

  The composition for oral cavity of the present invention further includes potassium nitrate, potassium citrate, strontium chloride, from the viewpoint of removing nerve sensitivity by changing the ion balance around the sensory nerve, or from the effect of desensitizing the nerve. And one or more desensitizers (D) selected from strontium acetate. These desensitizers (D) are water-soluble and are so-called nerve desensitizing components that can supply potassium ions or strontium ions, respectively, in the composition to change the ion balance around sensory nerves. is there. As the desensitizer (D), potassium nitrate and potassium citrate are more preferable from the viewpoint of improving the action of desensitizing the nerve.

  The content of the desensitizer (D) used in the present invention is such that when the composition for oral cavity is applied to the oral cavity, the ion balance around the sensory nerve is effectively changed by the desensitizer (D). From the viewpoint of reducing pain caused by dentin hypersensitivity, the molar concentration (mass molar concentration) in the oral composition of the present invention is preferably 0.4 to 0.6 mol / kg, or the present invention. The oral composition is more preferably 3 to 15% by mass, and further preferably 4 to 12% by mass.

  The oral composition of the present invention can further contain a wetting agent. Examples of the wetting agent include glycerin, sorbitol, propylene glycol, polyethylene glycol, xylitol, maltitol, lactol and the like. Of these, glycerin and sorbitol are preferred from the viewpoint of storage stability and flavor of the oral composition. When the oral composition of the present invention is a liquid oral composition such as a liquid dentifrice, a mouthwash, and a mouth freshener, the content of glycerin is used for the oral cavity of the present invention from the viewpoint of storage stability and flavor. In a composition, Preferably it is more than 0 mass%, More preferably, it is 1 mass% or more, Preferably it is 10 mass% or less, More preferably, it is 5 mass% or less. In addition, when the oral composition of the present invention is a toothpaste composition, the content of glycerin in the oral composition of the present invention is preferably more than 0% by mass from the viewpoint of storage stability and flavor, More preferably, it is 2 mass% or more, Preferably it is 20 mass% or less, More preferably, it is 15 mass% or less.

  The sorbitol content is such that when the oral composition of the present invention is a liquid oral composition such as a liquid dentifrice, mouthwash, and mouth freshener, from the viewpoint of storage stability and flavor, the oral composition of the present invention. In a composition, Preferably it is 1 mass% or more, More preferably, it is 5 mass% or more, Preferably it is 15 mass% or less, More preferably, it is 10 mass% or less. When the oral composition of the present invention is a toothpaste composition, the content of sorbitol is preferably 5% by mass or more in the oral composition of the present invention from the viewpoint of storage stability and flavor. More preferably, it is 10 mass% or more, More preferably, it is 15 mass% or more, Preferably it is 50 mass% or less, More preferably, it is 40 mass% or less.

  The composition for oral cavity of the present invention can further contain a binder. Examples of the binder include sodium alginate, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, and the like. Sodium carboxymethyl cellulose, carrageenan, xanthan gum Hydroxyethyl cellulose is preferable, and one or more selected from these can be used. When the oral composition of the present invention is a liquid dentifrice composition or a toothpaste composition, the content of the binder is preferably 0.2% by mass or more in the oral composition of the present invention, More preferably, it is 0.4 mass% or more, Preferably it is 2 mass% or less, More preferably, it is 1.5 mass% or less.

  When the oral composition of the present invention is a liquid dentifrice composition or a toothpaste composition, it is preferable to use a thickening silica together with the binder. The thickening silica is silica having an oil absorption of 200 to 400 mL / 100 g. Here, the amount of oil absorption indicates the amount of oil that can be supported by silica, and the measurement method is based on the method according to JIS K5101-13-2 (established in 2004), and the amount of oil absorbed in the boiled sea bream Identify. The content of the thickening silica is preferably 0.1 to 20% by mass, more preferably 1 to 10% by mass, and further preferably 2 in the liquid dentifrice composition or toothpaste composition of the present invention. It is -8 mass%.

  In addition to the above components, the oral composition of the present invention is an abrasive silica, dicalcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, alumina, hydroxylated as long as the effects of the present invention are not impaired. Polishing agents such as aluminum, magnesium acetate, dibasic magnesium phosphate, magnesium acetate, tribasic magnesium phosphate and zeolite; anionic surfactants such as sodium lauryl sulfate and sodium lauroylmethyl taurate, cationic surfactants, polyoxyethylene curing Surfactants such as nonionic surfactants such as castor oil, sucrose fatty acid ester, and sorbitan fatty acid ester; sweeteners such as saccharin sodium; fragrances such as menthol; dyes; Here, the term “abrasive silica” refers to those having an oil absorption of 50 to 150 mL / 100 g. Further, when the oral composition of the present invention is a toothpaste composition, the content of the abrasive is preferably 12% by mass or less, more preferably from the viewpoint of effectively sealing the opening of the dentinal tubule. Is 10 mass% or less, More preferably, it is 5 mass% or less, and it is not necessary to contain it.

  Furthermore, as long as the effects of the present invention are not impaired, fluorine ion supply compounds such as tin fluoride, sodium fluoride, and ammonium fluoride, fluorides such as sodium monofluorophosphate, aluminum lactate, calcium phosphate, hydroxyapatite, arginine -It may also contain other ingredients for dentin hypersensitivity such as calcium carbonate.

In the composition for oral cavity of the present invention, the pH is the viewpoint of maintaining high solubility in water of the basic amino acid salt of the fatty acid formed from the component (A) and the component (B), and good flavor and use. From the viewpoint of providing a feeling, it is 6 or more, preferably 6.5 or more, more preferably 7 or more, still more preferably 7.2 or more, and 9.2 or less, preferably 9 Or less, more preferably 8.8 or less.
The pH of the oral composition of the present invention is a value measured using a pH electrode, and when the oral composition of the present invention is a liquid oral composition, it is a value obtained by measuring the composition. When the oral composition of the present invention is a toothpaste composition, it means a value measured after adding distilled water to adjust the concentration of the dentifrice composition to a 10% by mass aqueous solution.

  The composition for oral cavity of the present invention includes, as a pH adjuster, citric acid, malic acid, lactic acid, tartaric acid, succinic acid, various salts thereof such as potassium salt, sodium salt and ammonium salt, potassium hydroxide, sodium hydroxide and the like An alkali agent other than the component (B) can be contained. These may be used alone or in combination of two or more. When an alkaline agent such as potassium hydroxide or sodium hydroxide is contained as a pH adjuster, the content of these components is stable from the viewpoint that the component (A) forms a basic amino acid salt of the fatty acid with the component (B). From the viewpoint of properties, the molar ratio (pH adjuster / (A)) with the molar concentration of the component (A) in terms of free fatty acid is preferably 0.5 or less, more preferably 0.3 or less, More preferably, it is 0.2 or less. Moreover, when it contains the said alkali agent as a pH adjuster, potassium hydroxide is preferable from viewpoints, such as storage stability.

  The manufacturing method of the composition for oral cavity of this invention includes the process 1 which adds and mixes a component (A), a component (B), and a component (C), and mixes another water-soluble component in this process 1. This step 1 is preferably followed by a step 2 in which a surfactant and an oil-soluble component are added and mixed. Moreover, when mix | blending desensitizers, such as potassium nitrate, in step 1, you may add and mix, but after step 1, you may add and mix. In Step 2, glycerin may be added and mixed together with a surfactant and an oil-soluble component.

  The manufacturing method of the composition for oral cavity of this invention is the process 1 which adds and mixes a part (C1) of a component (A), a component (B), and a component (C) previously, and the remainder of a component (C). A step 3 of adding and mixing (C2) can also be included. When components other than these components (A) to (C) are used, for example, the component (A) and the component (B) and a part (C1) of the component (C) are mixed in advance, and then the components are added thereto. The remainder (C2) of (C) and other components such as component (D) may be added and mixed as necessary. As a part (C1) of the component (C) to be mixed in advance, 50 to 100% by mass, preferably 70 to 90% by mass, of 100% by mass of the component (C) is used. In addition, content of a component (C) is the total amount of the water | moisture content previously contained in each component to mix | blend or add besides the component (C1) and (C2) to mix. In addition, in Step 1, when not adding the total amount of the component (C) to the component (A) and the component (B) but adding a part (C1) of the component (C) and mixing, the component (A ) Or a water-soluble component that inhibits the formation of the salt of component (B), it is preferable to add the above-mentioned inhibiting component together with the remainder (C2) and mix.

In relation to the embodiment described above, the present invention further discloses the following oral composition and method for producing the same.
[1] The following components (A), (B), and (C):
(A) Fatty acid having a hydrocarbon group having 12 to 18 carbon atoms (B) A basic amino acid, and (C) A molar concentration of component (B) in terms of free basic amino acid and component (A) A composition for oral cavity having a molar ratio ((B) / (A)) of a molar concentration in terms of free fatty acid of 1 or more and 37 or less and a pH of 6 or more and 9.2 or less.
[2] (A), (B), or a salt of (A) and (B), and (C):
(A) Fatty acid having a hydrocarbon group having 12 to 18 carbon atoms (B) A basic amino acid, and (C) A molar concentration of component (B) in terms of free basic amino acid and component (A) A composition for oral cavity having a molar ratio ((B) / (A)) with a molar concentration in terms of free fatty acid of 1 to 37 and a pH of 6 to 9.2.

[3] The difference ((B)-(A)) between the molar concentration of the component (B) in terms of free basic amino acid and the molar concentration of the component (A) in terms of free fatty acid is 0 mol / kg or more and 100 mol / kg. kg or less, preferably greater than 0 mol / kg, preferably 0.1 mol / kg or more, more preferably 0.5 mol / kg or more, further preferably 1 mol / kg or more, and 40 mol / kg or less. Preferably, the composition for oral cavity according to the above [1] or [2], which is more preferably 20 mol / kg or less.
[4] The molar ratio ((B) / (A)) between the molar concentration of the component (B) in terms of free basic amino acid and the molar concentration of the component (A) in terms of free fatty acid is 1.1 or more. 1.15 or more, 1.2 or more is more preferable, 15 or less, 7 or less is preferable, and 3 or less is more preferable, The oral composition of any one of said [1]-[3].

[5] The composition for oral cavity according to any one of the above [1] to [4], wherein the hydrocarbon group of the component (A) has 18 or less, preferably 16 or less, and 12 or more.
[6] The composition for oral cavity according to any one of the above [1] to [5], wherein the component (B) is arginine or lysine, more preferably arginine.
[7] Further contains a desensitizer (D), preferably the desensitizer (D) is one or more selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate, More preferably, the composition for oral cavity according to any one of the above [1] to [6], which is one or two selected from potassium nitrate and potassium citrate.
[8] The content of the desensitizer (D) is preferably a molar concentration of 0.4 to 0.6 mol / kg, or preferably 3 to 15% by mass, and 4 to 12% by mass. The composition for oral cavity according to [7], more preferably%.
[9] The pH is 6.5 or more, preferably 7 or more, more preferably 7.2 or more, 9.2 or less, preferably 9 or less, more preferably 8. The composition for oral cavity according to any one of [1] to [8], which is 8 or less.
[10] The molar concentration of the pH adjuster of the alkali agent is such that the molar ratio (pH adjuster / (A)) to the molar concentration of the component (A) in terms of free fatty acid is 0.5 or less, preferably 0.8. The composition for oral cavity according to any one of the above [1] to [8], which is 3 or less, more preferably 0.2 or less.
[11] The composition for oral cavity according to any one of the above [1] to [10], wherein the pH adjuster of the alkaline agent is one or two selected from sodium hydroxide and potassium hydroxide, preferably potassium hydroxide. object.
[12] The composition for oral cavity according to any one of the above [1] to [11], which is used for prevention or treatment of hypersensitivity of dentin.

[13] A composition for liquid oral cavity, wherein the content of the component (A) is 0.02% by mass or more, preferably 0.05% by mass or more, more preferably 0.8% by mass in terms of free fatty acid. 1% by mass or more, 1% by mass or less, preferably 0.7% by mass or less, and more preferably 0.5% by mass or less. Any one of the above [1] to [12] for oral cavity Composition.
[14] A composition for liquid oral cavity, wherein the content of component (B) is 0.02% by mass or more, preferably 0.05% by mass or more, more preferably in terms of free basic amino acid. Is 0.1% by mass or more, more preferably 0.2% by mass or more, 2% by mass or less, preferably 1.5% by mass or less, more preferably 1% by mass or less. The oral composition according to any one of [1] to [13], more preferably 0.8% by mass or less.
[15] A composition for liquid oral cavity, wherein the content of water (C) is 70% by mass or more, preferably 80% by mass or more, 95% by mass or less, preferably 90% by mass or less. The composition for oral cavity according to any one of [1] to [14] above.
[16] A composition for liquid oral cavity, which contains glycerin, the content of glycerin is more than 0% by mass, 10% by mass or less, preferably 1% by mass or more, preferably 5% by mass or less. The composition for oral cavity according to any one of the above [1] to [15].
[18] A composition for liquid oral cavity, which contains sorbitol, and the content of sorbitol is 1% by mass or more, preferably 5% by mass or more, and 15% by mass or less, preferably 10% by mass. % Of the composition for oral cavity according to any one of [1] to [16].

[19] A toothpaste composition, wherein the content of component (A) is 1.5% by mass or less in terms of free fatty acid, preferably 1.2% by mass or less, and more preferably 1. 0 mass% or less, more preferably 0.8 mass% or less, 0.15 mass% or more, preferably 0.2 mass% or more, more preferably 0.25 mass% or more. A composition for oral cavity according to any one of the above [1] to [12].
[20] A toothpaste composition, wherein the content of component (B) is 0.05% by mass or more, preferably 0.1% by mass or more, more preferably in terms of free basic amino acid. 0.2% by mass or more, 2% by mass or less, preferably 1.5% by mass or less, more preferably 1% by mass or less, and further preferably 0.8% by mass or less. The composition for oral cavity according to any one of [1] to [12] or [19].

[21] A toothpaste composition, wherein the content of water (C) is 8% by mass or more, preferably 10% by mass or more, more preferably 12% by mass or more, and 55% by mass or less. The composition for oral cavity according to any one of [1] to [12], [19] or [20], which is preferably 45% by mass or less, more preferably 40% by mass or less.
[22] A toothpaste composition comprising glycerin, the glycerin content being greater than 0% by mass, 20% by mass, and preferably 2-15% by mass [1]-[12] Or [19]-[21] The composition for oral cavity any one.
[23] A toothpaste composition comprising sorbitol, the sorbitol content being 5% by mass or more, preferably 10% by mass or more, more preferably 15% by mass or more, and 50% by mass or less. The composition for oral cavity according to any one of the above [1] to [12] or [19] to [22], which is preferably 40% by mass or less.

[24] A toothpaste composition, which contains a binder, and the binder content is 0.2% by mass or more, preferably 0.4% by mass or more, and 2% by mass or less. Yes, The composition for oral cavity of any one of said [1]-[12] or [19]-[23] which is 1.5 mass% or less preferably.
[25] A toothpaste composition comprising a thickening silica, wherein the content of the thickening silica is 0.1 to 20% by mass, preferably 1 to 10% by mass, more preferably 2 to 2%. The composition for oral cavity according to any one of the above [1] to [12] or [19] to [24], which is 8% by mass.

[26] The method for producing an oral composition according to any one of [1] to [25] above, comprising a step of adding and mixing the component (A), the component (B) and the component (C).
[27] The above step comprising adding and mixing a part of water of component (A), component (B) and component (C), and further adding and mixing the remaining water of component (C) [ 26] The manufacturing method of the composition for oral cavity of 26.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

[Examples 1-7, Comparative Examples 1-3]
The liquid oral composition having the composition shown in Table 1 was mixed with component (A), component (B), component (C) and other water-soluble components according to a conventional method, and the resulting mixture, surfactant, and fragrance It was produced by adding and mixing oil-soluble components such as. Each liquid oral composition obtained was evaluated for the sealed state of the opening of the dentinal tubule shown below. Moreover, about the composition for liquid oral cavity of the composition shown in Table 1, the inhibitory effect of the pain resulting from dentin hypersensitivity immediately after use was evaluated. The evaluation results are shown in Table 1, respectively.

《Evaluation of occluded state of ivory tubule》
Using bovine dentin as a sample, the sample was decalcified with a 1 molar aqueous lactic acid solution at room temperature for 30 minutes, and the surface was polished with sandpaper having an abrasive grain size of 40 μm and sandpaper having an abrasive grain size of 3 μm. The surface of this sample was immersed in 10 ml of the liquid oral composition of Examples and Comparative Examples for 30 seconds, and then the sample was washed with distilled water for 10 seconds. The opening of the dentinal tubule on the surface of the sample after washing was observed at a magnification of 2000 using a digital microscope (VHX-1000, manufactured by Keyence Co., Ltd.), and the opening state of the dentinal tubule was confirmed visually. Evaluation was made according to the criteria. The evaluation results are shown in Table 1.
AA: The opening of the dentinal tubule is sufficiently covered A: The opening of the dentinal tubule is almost covered B: The part where the opening of the dentinal tubule is covered and the part where the dentin is exposed are confirmed so
C: The deposit can be confirmed on the surface of the dentin, but the dentin is almost exposed. D: The dentinal tubule is exposed (the deposit cannot be confirmed on the surface of the dentin).

  1-3 is a microscope photograph showing the state of the sample after being treated with the liquid oral composition of Examples 1 and 2 and Comparative Example 1. FIG. As shown in FIG. 1, there are glossy deposits reflecting on the surface of the dentin, and the deposits seal the openings of the dentinal tubules. In FIG. 2, a portion where the opening of the dentinal tubule is covered with a deposit and a portion where the dentin is exposed are recognized. In FIG. 3, the dentin is exposed, no deposits are confirmed on the surface, and the opening of the dentinal tubule can be confirmed.

[Evaluation of the inhibitory effect of pain caused by dentine hypersensitivity]
About the liquid oral cavity composition of Examples 1-7 shown in Table 1, and Comparative Examples 1-3, the degree of the pain prevention resulting from dentin hypersensitivity immediately after use was evaluated. The panelists were those who evaluated their teeth every day during the last month or those who had several times a week. In the evaluation method, three panelists used each liquid oral composition, and cold water was included in the mouth immediately after use to evaluate pain caused by dentin hypersensitivity. The evaluation was answered from the following three categories: 3: No stain, 2: Slightly look, 1: Slightly look. Table 1 shows the total value of the panelists' responses as an evaluation of the effect of suppressing pain caused by dentine hypersensitivity. This evaluation means that the larger the numerical value, the more the pain caused by dentine hypersensitivity was suppressed or reduced.

<Method for evaluating storage stability>
Using the liquid oral compositions of Examples 1 to 7 and Comparative Examples 1 to 3 in Table 1, stored at room temperature (25 ° C.) for 1 week, at 5 ° C. for 1 week, and at 50 ° C. for 2 weeks, respectively. After that, changes in appearance were observed with the naked eye according to the following criteria. The results are shown in Table 1.
4: Almost unchanged from before storage 3: Yellowish 2: Slightly clouded 1: Precipitates were observed

《Taste evaluation method》
Taste evaluation was performed by 3 panelists according to the following criteria, after the liquid oral composition was included in the mouth and sprinkled for 20 seconds. Table 1 shows the total evaluation results.
3: Feel the oily flavor of fatty acids 2: Feel the oily taste of fatty acids slightly 1: Feel the oily flavor of fatty acids, and leave behind

  According to the results of Table 1, the compositions of Examples 1 to 7 exhibit excellent effects in suppressing pain caused by dentin hypersensitivity as compared with the compositions of Comparative Examples 1 to 3. It can be seen that the low temperature stability is excellent and the taste is also good. Since Comparative Examples 2 to 3 were solidified and could not be impregnated, the taste could not be evaluated.

[Examples 8 to 9]
A liquid oral composition having the composition shown in Table 2 was produced in the same manner as described above, and the sealed state of the opening of the dentinal tubule and the storage stability were evaluated in the same manner as described above. The evaluation results are shown in Table 2.

  As shown in Table 2, it can be seen that the liquid oral composition of any of the examples has a sealed dentinal tubule opening and good storage stability.

[Examples 10 to 12]
The toothpaste composition having the composition shown in Table 3 was mixed with component (A), component (B), component (C) and other water-soluble components according to a conventional method, and the resulting mixture, abrasive, and surface activity It was produced by adding and mixing oil-soluble components such as agents and fragrances. Using each of the obtained toothpaste compositions, the occluded state of the dentinal tubules shown below was evaluated and the taste was evaluated, and the storage stability was evaluated in the same manner as described above. The evaluation results are shown in Table 3.

《Evaluation of occluded state of ivory tubule》
Using bovine dentin as a sample, the sample was decalcified with a 1 molar aqueous lactic acid solution at room temperature for 30 minutes, and the surface was polished with sandpaper having an abrasive grain size of 40 μm and sandpaper having an abrasive grain size of 3 μm. The surface of this sample was immersed in 8 g of a solution obtained by mixing 2 g of the toothpaste compositions of Examples and Comparative Examples and 6 g of distilled water for 30 seconds, and then the sample was washed with distilled water for 10 seconds. The opening of the dentinal tubule on the surface of the sample after washing was observed at a magnification of 2000 using a digital microscope (VHX-1000, manufactured by Keyence Co., Ltd.), and the opening state of the dentinal tubule was confirmed visually. Evaluation was made according to the criteria.
AA: The opening of the dentinal tubule is sufficiently covered A: The opening of the dentinal tubule is almost covered B: The part where the opening of the dentinal tubule is covered and the part where the dentin is exposed are confirmed so
C: The deposit can be confirmed on the surface of the dentin, but the dentin is almost exposed. D: The dentinal tubule is exposed (the deposit cannot be confirmed on the surface of the dentin).

  FIG. 4 is a microscope photograph showing the state of the sample after being treated with the toothpaste composition of Example 10. As shown in FIG. 4, the surface of the dentine treated with the toothpaste composition of the example has glossy deposits reflecting on the light, and these deposits block the openings of the dentinal tubules. The state is recognized.

《Taste evaluation method》
To evaluate the taste, 1g of toothpaste composition was brushed with a toothbrush (Deep Clean Ultra Compact Normal / Kao Co., Ltd.) for 30 seconds, then spit out and the mouth was rinsed with water. It went by.
3: Feel the oily flavor of fatty acids 2: Feel the oily taste of fatty acids slightly 1: Feel the oily flavor of fatty acids, and leave behind

  As shown in Table 3, the toothpaste compositions of the examples were sealed in the opening of the dentinal tubules and were excellent in suppressing the pain caused by dentin hypersensitivity by actual use. On the other hand, in the toothpaste composition of the comparative example, the opening of the dentinal tubule was almost exposed, and the effect of suppressing pain caused by dentin hypersensitivity by actual use was hardly recognized.

[Example 13]
The toothpaste compositions having the compositions shown in Table 4 were produced in the same manner as the toothpaste compositions in Table 3, and the occlusion state and taste of dentinal tubules were similarly evaluated. The evaluation results are shown in Table 4.

  As shown in Table 4, it is recognized that the toothpaste compositions of the examples have a closed dentinal tubule and a good taste.

Claims (8)

The following components (A), (B), and (C):
(A) 0.1 mass% or more in terms of free fatty acid in terms of fatty acid having a hydrocarbon group having 12 to 18 carbon atoms (B) basic amino acid, and (C) free basic amino acid of component (B) containing water The molar ratio ((B) / (A)) between the molar concentration in terms of conversion and the molar concentration in terms of free fatty acids of component (A) is greater than 1 and 3 or less, and the oral cavity has a pH of 6 or more and 9.2 or less Composition. (D) potassium nitrate, potassium citrate, strontium chloride, and the oral composition of claim 1 containing one or more desensitizing agent selected from strontium acetate. The composition for oral cavity according to claim 1 or 2 , which is used for preventing or treating dentin hypersensitivity. It is a toothpaste composition, Comprising: The composition for oral cavity of any one of Claims 1-3 which contains 0.02 mass% or more and 1 mass% or less of component (A) in conversion of a free fatty acid. Contains one or more pH adjusting agents selected from citric acid, malic acid, lactic acid, tartaric acid, succinic acid, and potassium, sodium or ammonium salts thereof, and potassium hydroxide and sodium hydroxide. The composition for oral cavity of any one of Claims 1-4. The composition for oral cavity according to claim 5, wherein the molar ratio (pH adjuster / (A)) between the content of the pH adjuster and the molar concentration of the component (A) in terms of free fatty acid is 0.5 or less.   The manufacturing method of the composition for oral cavity of any one of Claims 1-6 provided with the process of mixing a component (A), a component (B), and a component (C).   The oral cavity according to claim 7, further comprising a step of mixing a part of water of the component (A), the component (B) and the component (C), and further adding and mixing the remaining water of the component (C). A method for producing the composition.