JP7337610B2 - oral composition - Google Patents

Description

The present invention relates to oral compositions.

Conventionally, in order to prevent oral diseases such as dental caries, periodontal disease and bad breath, it is effective to inhibit the formation of biofilms in the oral cavity and to remove already formed biofilms. Oral compositions have been developed using a variety of ingredients such as foaming agents, bactericidal agents, and the like. Among these components, erythritol, as also contained in the oral composition described in Patent Document 1, is an effective component for suppressing or dissociating the agglutination reaction between bacteria in the oral cavity, and biofilm. It is known not only for its inhibitory effect on biofilm formation, but also for its excellent effect in removing biofilms formed in gaps between teeth, such as between teeth and periodontal pockets.

On the other hand, potassium compounds such as potassium nitrate are known to exhibit a blunting action due to the released potassium ions and to be excellent in alleviating symptoms of hypersensitivity. For example, Patent Document 2 discloses an oral composition containing potassium nitrate, an acylamino-based anionic surfactant, a nonionic surfactant, and isopropylmethylphenol at specific blending ratios, and contains potassium ions. It is intended to reduce pain caused by dentin hypersensitivity by enhancing dissolution properties to sufficiently express nerve blunting action.

JP 2005-29484 A JP 2016-222579 A

However, in the use of erythritol, which has excellent biofilm formation inhibition and removal effects in the oral cavity as in Patent Document 1, pain caused by dentin hypersensitivity due to osmotic pressure stimulation caused by dissolution of erythritol in water is enhanced, and even if an attempt is made to provide an alleviation effect of hypersensitivity symptoms using a potassium compound such as potassium nitrate by referring to the description of Patent Document 2, the pain caused by sufficient dentin hypersensitivity The present inventor has found that it is difficult to reduce the
Thus, an oral composition that can effectively prevent pain caused by dentine hypersensitivity while enjoying the effect of removing oral biofilms by erythritol has not yet existed. is desired.

That is, the present invention relates to an oral cavity composition that exerts an excellent oral biofilm removal effect by erythritol and also exerts an excellent effect of suppressing dentin hypersensitivity.

Therefore, as a result of various studies, the present inventors have found that, while containing a specific amount of erythritol, a potassium compound such as potassium nitrate is further used in combination with an N-acylamino acid having a specific hydrocarbon group or a salt thereof, and By adjusting the erythritol and water to a specific mass ratio, it is possible to seal the openings of the dentin tubules on the exposed dentin surface while effectively exhibiting the oral biofilm removal effect of erythritol. As a result, it was found that an oral composition that can effectively prevent pain caused by dentin hypersensitivity can be obtained.

Accordingly, the present invention provides the following components (A), (B), (C) and (D):
(A) Erythritol 3% by mass or more and 33% by mass or less (B) Potassium compound (C) N-acyl amino acid having a hydrocarbon group with 14 to 18 carbon atoms or an alkali metal salt thereof (D) Water containing component ( The present invention provides an oral composition in which the mass ratio ((D)/(A)) of the content of D) to the content of component (A) is 1 or more and 10 or less.

According to the oral cavity composition of the present invention, erythritol can effectively block the openings of dentin tubules on the surface of exposed dentin while sufficiently exhibiting the effect of dispersing intraoral biofilms. That is, the oral cavity composition of the present invention is a highly useful composition that has both the effect of removing an intraoral biofilm and the effect of suppressing pain caused by dentin hypersensitivity.

FIG. 1 is an electron micrograph of the surface of dentin when the composition for oral cavity of Example 1 was used. FIG. 2 is an electron micrograph of the surface of dentin when the composition for oral cavity of Comparative Example 2 was used.

The present invention will be described in detail below.
In the present invention, "dentin tubule" is also referred to as "dentin tubule". In addition, "to block dentinal tubules" means to physically block dentinal tubules, and not only the state of covering the openings of dentinal tubules on the surface of dentin, but also the This also includes the state of filling and capping (stopping).

The oral composition of the present invention contains 3% by mass or more and 33% by mass or less of erythritol as the component (A). This, coupled with the coexistence of the component (C) described later, suppresses the agglutination reaction between bacteria, or dissociates the agglutination between bacteria, thereby inhibiting the formation of biofilms. Already formed biofilms can be removed even in narrow areas such as gaps such as circumferential pockets, and sufficient intraoral biofilms are produced while having excellent pain suppression effects caused by dentine hypersensitivity. It makes it possible to exert a dispersing effect.

The content of component (A) is 3% by mass or more, preferably 5% by mass or more, in the oral cavity composition of the present invention from the viewpoint of sufficiently exhibiting the biofilm removal effect. It is preferably 8% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more. In addition, the content of component (A) effectively avoids the enhancement of pain caused by dentine hypersensitivity due to osmotic stimulation caused by dissolution in water, From the viewpoint of ensuring that the effect of suppressing pain caused by dentin hypersensitivity is satisfactorily exhibited, the content of the oral cavity composition of the present invention is 33% by mass or less, preferably 32% by mass or less, and more preferably is 31% by mass or less, more preferably 30% by mass or less. The content of component (A) in the oral composition of the present invention is 3% by mass or more and 33% by mass or less, preferably 5 to 32% by mass, more preferably 8 to 31% by mass. %, more preferably 10 to 30% by mass, and even more preferably 20 to 30% by mass.

The oral composition of the present invention contains a potassium compound as component (B). As a result, while ensuring the effect of removing the biofilm by the component (A), after applying the oral composition of the present invention to the oral cavity, potassium ions are rapidly released, and the component (C) described later. Rapidly forms an N-acylamino acid potassium salt having a hydrocarbon group of 14 to 18 carbon atoms that is stably dissolved in a substance, and such salt effectively seals dentinal tubules by acting on the surface of dentin. However, it is possible to exhibit the effect of suppressing the enhancement of pain caused by dentin hypersensitivity due to osmotic stimulation caused by dissolution of component (A) in water. Among such component (B), not only from the viewpoint of blunting action by released potassium ions, but also from the viewpoint of enhancing the sealing effect of dentinal tubules together with the above component (C), and suppressing pain caused by dentine hypersensitivity. From the viewpoint of improving the effect, one or two or more potassium compounds selected from potassium nitrate, tripotassium citrate, potassium acetate and potassium hydroxide are preferable, and among them one or two selected from potassium nitrate and potassium hydroxide. Seeds are more preferred, and combinations of these are preferred. In addition, the component (B) means a potassium compound other than the component (C) described later.

The content of component (B) is preferably 0.001% by mass or more in the oral composition of the present invention from the viewpoint of promoting rapid release of potassium ions after the composition is applied to the oral cavity. Yes, more preferably 0.01% by mass or more, still more preferably 0.05% by mass or more, still more preferably 2% by mass or more, still more preferably 3% by mass or more, and particularly Preferably, it is 4% by mass or more. In addition, the content of component (B) is preferably 10% by mass or less, more preferably 8% by mass or less, in the oral composition of the present invention from the viewpoint of preventing unpleasant taste. , more preferably 7% by mass or less. The content of component (B) in the oral composition of the present invention is preferably 0.001% by mass or more and 10% by mass or less, more preferably 0.01 to 10% by mass, and further It is preferably 0.05 to 10% by mass, still more preferably 2% to 10% by mass, even more preferably 3 to 8% by mass, and even more preferably 4 to 7% by mass. .

The mass ratio of the content of component (A) to the content of component (B) ((B) / (A)) is the effect of removing oral biofilm and the dissolution of component (A) in water. It is preferably 0.1 or more, more preferably 0.13 or more, from the viewpoint of having the effect of suppressing the enhancement of pain caused by dentine hypersensitivity due to osmotic stimulation. , more preferably 0.15 or more, still more preferably 0.18 or more, even more preferably 0.2 or more, preferably 1.5 or less, more preferably 1.25 or less , more preferably 1 or less, and even more preferably 0.8 or less.

The oral composition of the present invention contains, as component (C), an N-acylamino acid having a hydrocarbon group of 14 to 18 carbon atoms or an alkali metal salt thereof. By containing such a component (C), when the oral composition of the present invention is applied to the oral cavity, it has a hydrocarbon group having 14 to 18 carbon atoms together with potassium ions released by the component (B). An N-acylamino acid potassium salt having a hydrocarbon group of 14 to 18 carbon atoms, which rapidly forms an N-acylamino acid potassium salt, or allows potassium ions to be abundantly present in the oral composition by the component (B). can be sufficiently distributed in the composition of the present invention throughout the oral cavity to easily reach the desired dentin surface. Furthermore, when such a salt reaches the surface of dentin, the substitution of the potassium salt of N-acylamino acid with the calcium salt of N-acylamino acid proceeds rapidly, and a hydrocarbon group having 14 to 18 carbon atoms is formed. Since the precipitate of the calcium salt of N-acylamino acid having firmly adheres to the surface of dentin, it is possible to effectively block dentinal tubules and effectively enhance the pain suppressing effect. ) does not interfere with the biofilm removal effect.

The amino acid moiety of the N-acylamino acid having a hydrocarbon group of 14 to 18 carbon atoms in component (C) is one selected from glutamic acid, glycine and alanine, or from the viewpoint of exerting an excellent dentinal tubule sealing effect. Two or more are preferred, and one or two selected from glutamic acid and glycine are more preferred from the viewpoint of more effectively and rapidly sealing dentinal tubules, and glycine is even more preferred. In addition, these amino acid moieties may be in the D-configuration, the L-configuration, or a mixture of the D- and L-configurations, preferably the L-configuration.

The acyl group of the N-acylamino acid in component (C) has a hydrocarbon group with 14 to 18 carbon atoms from the viewpoint of exhibiting an excellent dentinal tubule sealing effect. Such N-acylamino acids having a hydrocarbon group of 14 to 18 carbon atoms or alkali metal salts thereof are derived from fatty acids having saturated or unsaturated straight or branched chains or mixed fatty acids thereof. It is more preferable to have a hydrocarbon group with 14 to 16 carbon atoms. That is, as the acyl group having a hydrocarbon group with such a carbon number, a plurality of types of hydrocarbon groups with the above carbon number may be mixed, but from the viewpoint of sufficiently exhibiting an excellent effect of blocking the opening of dentinal tubules. , myristoyl group, palmitoyl group and stearoyl group are preferred, and a myristoyl group is more preferred.

Examples of the alkali metal salt of N-acylamino acid having a hydrocarbon group of 14 to 18 carbon atoms in component (C) include sodium and potassium, with potassium being preferred.

The content of the component (C) forms a potassium salt that rapidly dissolves stably in the composition together with the potassium ions released by the component (B), and the salt acts on the surface of the dentin to produce an effect. From the viewpoint of effectively blocking dentinal tubules and effectively suppressing pain, the acid-equivalent amount in the oral cavity composition of the present invention is preferably 0.01% by mass or more, more preferably 0.05% by mass. It is at least 0.1% by mass, and more preferably at least 0.1% by mass. In addition, from the viewpoint of ensuring good flavor, the content of component (C) in the oral cavity composition of the present invention is preferably 2% by mass or less, more preferably 1.5%, in terms of acid. % by mass or less, more preferably 1% by mass or less. The content of component (C) in the oral cavity composition of the present invention, in terms of acid, is preferably 0.01% by mass or more and 2% by mass or less, more preferably 0.05 to 1.0% by mass. It is 5% by mass, more preferably 0.1 to 1% by mass.
Here, the "acid conversion amount" means that the content of component (C) is expressed in terms of N-acylamino acid having a hydrocarbon group of 14 to 18 carbon atoms.
N-acyl amino acids or alkali metal salts thereof having an acyl group that may contain a hydrocarbon group with a carbon number other than the above carbon number while a plurality of types of hydrocarbon groups having the above carbon number are mixed, such as a cocoyl group, are used. When used in the oral composition of the present invention, the content of the N-acylamino acid having a hydrocarbon group with the above carbon number or the alkali metal salt thereof should be the content of the above component (C). good.

The mass ratio ((C)/(A)) between the acid equivalent amount of component (C) and the content of component (A) is the effect of removing oral biofilm and the dissolution of component (A) in water. It is preferably 0.001 or more, more preferably 0 It is 0.004 or more, more preferably 0.008 or more, preferably 0.035 or less, more preferably 0.03 or less, still more preferably 0.02 or less.

The oral composition of the present invention contains water as component (D). By adjusting the water content, it is possible to effectively avoid the enhancement of pain caused by dentine hypersensitivity due to osmotic pressure stimulation caused by dissolution of component (A) in component (D). do. In addition, the potassium ion released from the component (B) is present in the composition, and the N-acylamino acid potassium salt having the specific carbon number that exhibits stable solubility due to the component (B) and the component (C) is added. It is possible to effectively block the dentinal tubules while allowing the agent to exist and to spread it to every corner of the oral cavity, and to exhibit a sufficient biofilm removal effect.

The content of component (D) is determined from the viewpoint of suppressing osmotic stimulation caused by dissolution of component (A) in component (D), and stable solubility by component (B) and component (C). From the viewpoint of efficiently forming the N-acylamino acid potassium salt having the specific carbon number shown above to improve the dentinal tubule sealing effect, and from the viewpoint of effectively exhibiting the biofilm removal effect by the component (A), the present invention It is preferably 8% by mass or more, more preferably 10% by mass or more, still more preferably 12% by mass or more, still more preferably 15% by mass or more, and still more preferably is 33% by mass or more, still more preferably 34% by mass or more, still more preferably 40% by mass or more, even more preferably 45% by mass or more, preferably less than 60% by mass, It is more preferably 55% by mass or less, still more preferably 50% by mass or less.

The mass ratio of the content of component (D) to the content of component (A) ((D) / (A)) ensures an excellent biofilm removal effect by component (A), while maintaining component (A) is 1 or more, preferably 2 or more, and more preferably 3, from the viewpoint of improving the dentinal tubule sealing effect by appropriately controlling the osmotic pressure stimulus caused by the dissolution of the component (D). more preferably 3.5 or more, 10 or less, preferably 9 or less, more preferably 5 or less.

The oral composition of the present invention can further contain a fatty acid divalent metal salt (E) having a hydrocarbon group of 12 to 18 carbon atoms. Thereby, the pain suppressing effect caused by dentine hypersensitivity can be further enhanced. Such component (E) is derived from a saturated fatty acid having 12 to 18 carbon atoms and is composed of two saturated fatty acids and a divalent metal. Specific examples of the saturated fatty acids derived from it include lauric acid, myristic acid, pentadecylic acid, palmitic acid, margaric acid, and stearic acid. Among them, lauric acid, myristic acid, palmitic acid and stearic acid are preferred, and lauric acid, myristic acid and stearic acid are more preferred. The two saturated fatty acids that constitute component (E) are preferably the same. Specific examples of divalent metals include zinc, calcium, magnesium, strontium, and barium. Among them, zinc, calcium, and magnesium are preferable, and zinc and calcium are more preferable, from the viewpoint of effectively enhancing the pain suppressing effect caused by dentine hypersensitivity and from the viewpoint of applicability to the oral cavity.
More specifically, zinc stearate is preferred as component (E).

The content of component (E) is preferably 0.1 to 3 in the oral composition of the present invention from the viewpoint of enhancing the sealing property of the openings of dentin tubules and maintaining good flavor. % by mass, more preferably 0.2 to 2% by mass, still more preferably 0.4 to 1.8% by mass.

The oral composition of the present invention can further contain maltitol (F). As a result, it is possible to effectively suppress unnecessary crystal growth of the component (A) and ensure an excellent biofilm removal effect, and the dissolution of the component (A) in the component (D) is a factor It is possible to effectively suppress the enhancement of pain caused by dentin hypersensitivity due to osmotic stimulation, while maintaining high stability of the composition and ensuring a good appearance. It is also possible to secure a good flavor.

The content of component (F) is preferably 1 It is up to 30% by mass, more preferably 3 to 20% by mass, and still more preferably 5 to 15% by mass.

When the oral composition of the present invention is a toothpaste composition, it may contain up to 10% by weight of abrasive or no abrasive. Examples of such abrasives include abrasive silica, dicalcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide, magnesium acetate, dimagnesium phosphate, magnesium acetate, and tertiary phosphate. One or two or more selected from abrasives such as magnesium and zeolite can be used. Among these, from the viewpoint of suppressing an excessive increase in the pH of the composition, an abrasive containing at least abrasive silica is preferred, and an abrasive comprising only abrasive silica is more preferred.
Here, abrasive silica refers to one having an oil absorption of 50 to 150 mL/100 g, and the oil absorption indicates the amount of oil that silica can support. by the amount of boiled linseed oil absorbed.

The content of the abrasive in the oral cavity composition of the present invention is preferably It is 10% by mass or less, more preferably 8% by mass or less, and still more preferably 4% by mass or less, and provides excellent flavor while achieving both excellent biofilm removal effect and dentinal tubule sealing effect. is preferably more than 0% by mass, more preferably 2% by mass or more.

The oral composition of the present invention may further contain a humectant in addition to the above ingredients. Such humectants include one or more selected from glycerin, propylene glycol, polyethylene glycol, sorbitol, xylitol and lactol, and one or more selected from sorbitol, glycerin, xylitol and propylene glycol. is preferred, and one or two selected from sorbitol and propylene glycol are more preferred. The total content of the humectant is preferably 5% by mass or more, more preferably 8% by mass or more, preferably 60% by mass or less, more preferably 45% by mass or less, even more preferably 40% by mass or less, still more preferably It is 35% by mass or less.

The oral composition of the present invention can further contain a binder. Such binders include one or more selected from sodium alginate, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, gum tragacanth, gum arabic, guar gum, and the like. mentioned. Among them, one or two or more selected from sodium alginate, sodium carboxymethylcellulose, carrageenan, xanthan gum, and hydroxyethylcellulose are preferable, and one or two or more selected from sodium carboxymethylcellulose and carrageenan are particularly preferable.
When the oral composition of the present invention is a toothpaste composition, the content of such a binder in the oral composition of the present invention is preferably 0.2% by mass or more, more preferably 0.2% by mass or more. 4% by mass or more, preferably 3% by mass or less, more preferably 2.5% by mass or less, and even more preferably 1.8% by mass or less.

The oral composition of the present invention can further contain an amphoteric surfactant as component (G). Such amphoteric surfactants include one or more selected from alkylamidopropylbetaines such as coconut oil fatty acid amidopropylbetaine and alkylhydroxysulfobetaines such as laurylhydroxysulfobetaine.
The content of the component (G) amphoteric surfactant is preferably 0.05 mass in the oral cavity composition of the present invention from the viewpoint of moderately controlling the osmotic pressure stimulation of the component (A) by its foaming property. % or more, more preferably 0.1% by mass or more, still more preferably 0.25% by mass or more, preferably 3% by mass or less, more preferably 2% by mass or less, and still more preferably is 0.8% by mass or less.

The mass ratio of the content of component (G) to the content of component (A) ((G) / (A)) ensures an excellent biofilm removal effect by component (A), while maintaining component (A) is preferably 0.001 or more, more preferably 0.5 or more, and still more preferably 0.1 or more, from the viewpoint of improving the dentinal tubule sealing effect by appropriately controlling the osmotic pressure stimulation of , preferably 0.05 or less.

When the oral cavity composition of the present invention is a toothpaste composition, it is preferable to use thickening silica together with the above-mentioned binder. Thickening silica is silica with an oil absorption of 200 to 400 mL/100 g. Here, the oil absorption indicates the amount of oil that silica can support, and the measurement method is specified by the amount of boiled linseed oil absorbed according to JIS K5101-13-2 (established in 2004). The content of thickening silica in the oral composition of the present invention is preferably 0.1 to 20% by mass, more preferably 1 to 10% by mass, and still more preferably 2 to 8% by mass. be.

The oral composition of the present invention contains, in addition to the above components, an anionic surfactant such as sodium lauryl sulfate or sodium lauroyl methyl taurate, a cationic surfactant, coconut oil fatty acid amidopropyl betaine, within a range that does not inhibit the effects of the present invention. Surfactants such as amphoteric surfactants such as polyoxyethylene hydrogenated castor oil, sucrose fatty acid esters, nonionic surfactants such as sorbitan fatty acid esters; sweeteners such as saccharin sodium; fragrances; can contain.

Furthermore, within a range that does not impair the effects of the present invention, fluoride ion supplying compounds such as tin fluoride, sodium fluoride and ammonium fluoride, fluorides such as sodium monofluorophosphate, titanium oxide, aluminum lactate, calcium phosphate, hydroxyl Other ingredients such as apatite, arginine-calcium carbonate, etc. may also be included.

Potassium contained in the oral composition of the present invention exists in ionic or salt form in the oral composition of the present invention. For example, such potassium is present as potassium ions released from component (B) and, when component (C) is a potassium salt, as potassium forming such a salt.
The total amount of potassium present in the ionic or salt form in the oral composition of the present invention is the oral cavity of the present invention from the viewpoint of promoting rapid release of potassium ions after application of the composition to the oral cavity. It is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and still more preferably 0.5% by mass or more in the composition for use. In addition, the total amount of potassium present in the oral cavity composition of the present invention is preferably 6% by mass or less, more preferably 4% by mass or less, and still more preferably from the viewpoint of preventing an unpleasant taste. It is 2% by mass or less. The total amount of potassium present in the oral cavity composition of the present invention is preferably 0.05% by mass or more and 6% by mass or less, more preferably 0.1 to 4% by mass, and still more preferably 0.1% by mass or more. It is 5 to 2% by mass.
The total amount of potassium present in the oral cavity composition can be measured by ion chromatography, ICP emission spectrometry, or the like.

In addition, the mass ratio of the content of component (C) and the total amount of potassium ((C)/potassium) is the viewpoint of promoting rapid release of potassium ions after application of the composition to the oral cavity and unpleasant taste From the viewpoint of preventing the feeling of 0.5 or less, more preferably 0.3 or less.

The pH of the oral composition of the present invention at 25°C is preferably 6.5 or higher, more preferably 7 or higher, from the viewpoint of promoting salt formation by the component (B) and the component (C). More preferably 7.5 or more, preferably 9.5 or less, more preferably 9 or less, still more preferably from the viewpoint of ensuring good flavor while preventing discoloration of the composition and modulation of fragrance. is 8.5 or less.
The pH of the oral composition of the present invention is a value measured at 25°C using a pH electrode. When the oral composition of the present invention is a toothpaste composition, it is measured after adjusting to an aqueous solution with a concentration of 10% by mass with ion-exchanged water or purified water consisting of distilled water. value.

INDUSTRIAL APPLICABILITY The oral composition of the present invention exhibits an excellent biofilm removal effect and can effectively prevent pain caused by dentin hypersensitivity. That is, it can also be widely used as a dentin hypersensitivity reducing agent or preventive agent.

The method for producing the oral cavity composition of the present invention is not particularly limited, and the above ingredients may be appropriately mixed by a conventional method.
Specifically, for example, step (I) of obtaining and heating a mixture containing component (B) and at least a part of component (D) and having a pH of 9 or more at 25 ° C., obtained in step (I) It is preferred to have a step (II) of mixing component (C) into the mixture obtained in step (II) and a step (III) of adding component (A) to the mixture obtained in step (II). The temperature for heating the mixture in step (I) is preferably 40°C or higher, more preferably 50°C or higher, still more preferably 55°C or higher, preferably 100°C or lower, and more preferably 80°C. It is below.
In this step (II), the mixture obtained in step (I) should be mixed with other water-soluble components. Other water-soluble components include, for example, fluoride ion-providing compounds, water-soluble components such as sodium saccharin. A binder can also be added and mixed.

Further, in step (III), it is preferable to add powder such as a surfactant and an abrasive while adding component (A). In this step (II) or step (III), the remainder of component (D) may be added and mixed.
Furthermore, after the step (III), a step (IV) of adding a perfume to the mixture obtained in the step (III) and mixing at a room temperature of 15 to 30° C. may be provided.

In relation to the above-described embodiments, the present invention further discloses the following oral compositions.
[1] The following components (A), (B), (C) and (D):
(A) Erythritol 3% by mass or more and 33% by mass or less (B) Potassium compound (C) N-acyl amino acid having a hydrocarbon group with 14 to 18 carbon atoms or an alkali metal salt thereof (D) Water containing component ( An oral cavity composition in which the mass ratio ((D)/(A)) of the content of D) to the content of component (A) is 1 or more and 10 or less.
[2] The content of component (A) is preferably 5% by mass or more, more preferably 8% by mass or more, still more preferably 10% by mass or more, and even more preferably 20% by mass or more. preferably 32% by mass or less, more preferably 31% by mass or less, and even more preferably 30% by mass or less.
[3] The mass ratio of the content of component (A) to the content of component (B) ((B)/(A)) is preferably 0.1 or more, more preferably 0.13 or more. , more preferably 0.15 or more, still more preferably 0.18 or more, even more preferably 0.2 or more, preferably 1.5 or less, more preferably 1.25 or less , more preferably 1 or less, and even more preferably 0.8 or less.

[4] The amino acid portion of the N-acylamino acid in component (C) is preferably one or more selected from glutamic acid, glycine and alanine, more preferably one or two selected from glutamic acid and glycine. and more preferably glycine.
[5] The above [1], wherein the acyl group of the N-acylamino acid in component (C) is preferably one or more selected from a myristoyl group, a palmitoyl group and a stearoyl group, and more preferably a myristoyl group. ~ [4] The composition for oral cavity of any one.
[6] The content of component (C), in terms of acid, is preferably at least 0.01% by mass, more preferably at least 0.05% by mass, and still more preferably at least 0.1% by mass. preferably 2% by mass or less, more preferably 1.5% by mass or less, and still more preferably 1% by mass or less, any one of [1] to [5] above.
[7] The mass ratio ((C)/(A)) of the acid-equivalent amount of component (C) to the content of component (A) is preferably 0.001 or more, more preferably 0.004 or more. , more preferably 0.008 or more, preferably 0.035 or less, more preferably 0.03 or less, and still more preferably 0.02 or less Any of the above [1] to [6] or 1 oral cavity composition.

[8] The content of component (D) is preferably 8% by mass or more, more preferably 10% by mass or more, still more preferably 12% by mass or more, and even more preferably 15% by mass or more. Yes, more preferably 33% by mass or more, still more preferably 34% by mass or more, still more preferably 40% by mass or more, even more preferably 45% by mass or more, preferably 60% by mass %, more preferably 55% by mass or less, and still more preferably 50% by mass or less, any one of the above [1] to [7].
[9] The mass ratio of the content of component (D) to the content of component (A) ((D)/(A)) is preferably 2 or more, more preferably 3 or more, and still more preferably is 3.5 or more, preferably 9 or less, more preferably 5 or less, any one of the above [1] to [8].
[10] Any one of the above [1] to [9], which further contains a fatty acid divalent metal salt (E) having a hydrocarbon group with 12 to 18 carbon atoms, and the component (E) is preferably zinc stearate. 1 oral composition.
[11] The content of component (E) is preferably 0.1 to 3% by mass, more preferably 0.2 to 2% by mass, still more preferably 0.4 to 1.8% by mass. The oral composition according to any one of [1] to [10] above.

[12] It further contains maltitol (F), and the content of component (F) is preferably 1 to 30% by mass, more preferably 3 to 20% by mass, and still more preferably 5 to 15% by mass. %.
[13] The content of component (B) is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.05% by mass or more, and even more preferably is 2% by mass or more, more preferably 3% by mass or more, even more preferably 4% by mass or more, preferably 10% by mass or less, more preferably 8% by mass or less, and further The composition for oral cavity according to any one of the above [1] to [12], which is preferably 7% by mass or less.
[14] It further contains an amphoteric surfactant (G), and the content of component (G) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and still more preferably Any one of the above [1] to [13], which is 0.25% by mass or more, preferably 3% by mass or less, more preferably 2% by mass or less, and further preferably 0.8% by mass or less oral composition.
[15] The mass ratio of the content of component (G) to the content of component (A) ((G)/(A)) is preferably 0.001 or more, more preferably 0.5 or more. and more preferably 0.1 or more and preferably 0.05 or less.
[16] Step (I) of obtaining and heating a mixture containing component (B) and at least a part of component (D) and having a pH of 9 or more at 25 ° C., component in the mixture obtained in step (I) Step (II) of mixing (C), and Step (III) of adding component (A) to the mixture obtained in step (II), preferably at 15 to 30 ° C. after step (III) A method for producing an oral composition according to any one of [1] to [15] above, comprising step (IV) of adding a flavoring agent to the mixture obtained in step (III) and mixing at room temperature.

EXAMPLES The present invention will be specifically described below based on examples. In addition, unless otherwise indicated in the table, the content of each component indicates % by mass.

[Examples 1 to 11, Comparative Examples 1 to 6]
The oral compositions shown in Tables 1 and 2 were produced by mixing each component by the production method described above. The content of component (C) in Tables 1 and 2 is shown in terms of acid.
Using each obtained composition, each evaluation was performed according to the methods and criteria shown below.

《Evaluation of the closed state of the opening of the ivory tubule》
The surface of each approximately 1 cm section (approximately 500 μm thick) of bovine dentin was mirror-polished using sandpaper with an abrasive grain size of 40 μm and sandpaper with an abrasive grain size of 3 μm, and then subjected to ultrasonic treatment for 10 minutes. did. Next, etching treatment is performed with a 1% citric acid aqueous solution for 20 seconds, and ultrasonic treatment is performed again for 10 minutes to completely remove the smear layer and expose the opening of the dentinal tubule of the bovine dentin, A dentin sample was used.
Next, 1 g of each composition was applied to a toothbrush (Deep Clean Ultra Compact, Ordinary, manufactured by Kao Corporation), and after brushing the dentin sample for 1 minute, the sample was washed with distilled water for 10 seconds. Platinum was deposited on the surface of the sample after washing, and the dentin surface was photographed at a magnification of 2000 using an electron microscope (VE-7800, manufactured by KEYENCE, accelerating voltage 2 kV). evaluated the condition.
Electron micrographs of Example 1 and Comparative Example 2 are shown in FIGS. 1 and 2, respectively.
As shown in FIG. 1, in Example 1, the openings of the dentinal tubules were sufficiently covered, whereas in Comparative Example 2 shown in FIG. , it can be seen that the dentinal tubules are almost exposed.

《Hypersensitivity sensory evaluation》
Each composition shown in Tables 1-2 was evaluated for the degree of pain prevention resulting from dentin hypersensitivity immediately after use. A panel of subjects for evaluation was made up of those who experienced tooth sensitivity every day in the last month, or those who experienced tooth sensitivity more than 2-3 times a week. The evaluation method was as follows: 3 panelists took 1 g of each oral composition on a toothbrush (Deep Clean Super Compact, Ordinary, manufactured by Kao Corporation), brushed for 1 minute, spit it out, rinsed the mouth with water, and rinsed the mouth with cold water immediately after use. was held in the mouth, and the pain caused by dentine hypersensitivity was evaluated.
For evaluation, answers were obtained from among 4: 4: no stain, 3: almost no stain, 2: slightly stain, 1: stain, and the average value of the panelist's answers was attributed to dentin hypersensitivity. It was used as an evaluation of the pain suppressing effect.
The results are shown in Tables 1-2.
In addition, it means that the pain resulting from dentine hypersensitivity was suppressed or reduced, so that a numerical value is large.

<<Evaluation method for plaque removal>>
1) Collection of stimulated saliva Healthy men in their 20s and 30s were asked to chew gum pellets contained in Dent Buff Strips (OralCare Inc.), and saliva collected in their mouths was collected each time. Saliva was collected in Falcon tubes by having them expectorate into the Falcon tubes. Since there are individual differences in bacteria in saliva, plaque removal properties were evaluated for all Examples and Comparative Examples using the saliva of one healthy male.
2) Preparation of Plaque Model Saliva collected in a falcon tube was centrifuged at 3000 rpm/rt (25° C.)/10 min (refrigerated centrifuge CF15RN, manufactured by HITACHI). Using the separated supernatant saliva, sucrose was added to make a 5% by mass solution, and then stirred using a stirring device (Voltex, manufactured by Nippon Genetics Co., Ltd.) to prepare a dental plaque model test solution.
Next, one side of an HAp substrate (manufactured by Cosmo Bio Co., Ltd., 1 cm square) was mirror-polished using abrasive papers of 40 μm, 12 μm, and 3 μm, and then immersed in 1N HCl for 1 minute for acid decalcification. After the treated HAp plate was washed with ion-exchanged water and dried, placed in a 24-well plate, 1 mL each of the dental plaque model test solution prepared above was added, and then this was stored in a plastic case together with a CO ₂ pack and anaerobic. conditioned and cultured at 37° C. for 48 hours.

3) Evaluation of Plaque Removal Using a vacuum pump, saliva in the plate was sucked, 1 mL of ion-exchanged water was added, and the plate was shaken for 5 minutes. Next, water was sucked up using a pump, and 1 mL of each composition obtained in Examples and Comparative Examples was added and shaken for 5 to 20 minutes. Shaking was performed using a shaker (BioShake iQ (Waken Bee Tech Co., Ltd.)) at room temperature (25° C.) and 500 rpm.
After that, each composition was sucked up, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes, and this was repeated twice. Then, the water was blotted, 750 μL of 0.1 mass % crystal violet (CV) solution was added, and the mixture was shaken for 15 minutes.
Further, the CV staining solution was sucked up with a pump, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes, and this was repeated twice. Next, the water is sucked up with a pump, 500 μL of ethanol is added and pipetted, and then the extract is diluted 10-fold with ion-exchanged water and read with a microplate recorder (Sunrise Rainbow Thermo, variable wavelength absorbance microplate reader manufactured by TECAN). Absorbance OD _595nm was measured.
Also, based on the absorbance OD _{595 nm} (initial value) of only washing with deionized water without using the composition obtained above, the plaque retention rate (%) was calculated according to the following formula.
Plaque residual rate (%) = {OD 595 nm when using the composition obtained above / OD _{595 nm after} washing with ion-exchanged water} x 100
Based on the value of the plaque retention rate (%) obtained, the plaque removal property was evaluated according to the following criteria. In addition, it means that the smaller the value of the obtained plaque retention rate, the higher the plaque-removing property.
The results are shown in Tables 1-2.
AA: Sufficiently high plaque removal (less than 40% residual plaque rate)
A: High plaque removability (plaque residual rate of 40% or more and less than 60%)
B: Slightly high plaque removal (plaque residual rate of 60% or more and less than 80%)
C: Low plaque removal (plaque retention rate of 80% or more)

Claims (5)

The following components (A), (B), (C) and (D):
(A) Erythritol 3% by mass or more and 33% by mass or less (B) Potassium nitrate
(C) an N-acylamino acid having a hydrocarbon group with 14 to 18 carbon atoms or an alkali metal salt thereof (D) containing water, the mass ratio of the content of component (D) to the content of component (A) ((D)/(A)) is 1 or more and 10 or less, and the mass ratio ((B)/(A)) of the content of component (B) to the content of component (A) is 0.1 or more 1.5 or less oral composition. The oral composition according to Claim 1, wherein the amino acid portion of the N-acylamino acid in component (C) is one or more selected from glutamic acid, glycine and alanine. 3. The oral composition according to claim 1, further comprising a fatty acid divalent metal salt (E) having a hydrocarbon group with 12 to 18 carbon atoms. 4. An oral composition according to claim 3, wherein component (E) is zinc stearate. The oral composition according to any one of claims 1 to 4, which is an oral composition for dentine hypersensitivity.