JP2003113092A - Fluorine-containing sheet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a fluorine-containing sheet capable of making fluorine effectively penetrate into pit and fissure parts which are a favorite site of dental caries and supplying the parts with the fluorine, by being occluded, capable of increasing an amount of the fluorine retained on occlusal surfaces for a long time, capable of supplying deep areas of the pit and fissure parts with the fluorine, and therefore capable of preventing the dental caries from developing and advancing on the occlusal surfaces. SOLUTION: This intraoral fluorine-containing sheet for occlusion is formed by coating each of surfaces of a support base with a plasterlike material containing a fluorine compound.

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fluorine-containing sheet for effectively penetrating and supplying fluoride to a pit or fissure, which is a site where caries is frequently caused. By occlusion of the fluorine-containing sheet of the present invention, fluoride is supplied deep into the pit and fissure for a long time, thereby making it possible to suppress the occurrence and progress of caries on the occlusal surface. 2. Description of the Related Art
Not only for permanent teeth, the pit and fissure of the posterior occlusal surface is a common site of caries, even when compared to other sites such as smooth surfaces and adjacent surfaces.
It is known that the incidence of caries is extremely high. The pit fissure has a small inner diameter of several tens of microns, and its shape is complicated. Therefore, it is considered that plaque is insufficiently removed because the bristles of the brush cannot be reached with ordinary toothpaste, and as a result, the plaque is susceptible to cariogenic bacteria and caries is likely to occur. Further, since the pit and fissure portion has a complicated shape as described above, it is difficult for an effective ingredient such as fluoride to reach deep into the pit and fissure. [0003] Conventionally, in the field of caries preventive dentifrices, it has been practiced to blend fluorine compounds such as sodium fluoride and sodium monofluorophosphate as active ingredients.
However, it acts directly on the smooth surface and the adjacent surface to promote remineralization, but at present, no fluoride acts on the inside of the pit fissure due to its complicated shape. [0004] In addition, local application of fluoride by fluoride varnish has been carried out mainly in Northern Europe, but this treatment is performed about twice a year, and it is considered that fluoride is sufficiently supplied to the pit and fissure. I can't say. The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a fluorine-containing sheet for oral occlusion in which fluoride is permeated and supplied into the pit and fissure for a long time. Means for Solving the Problems and Embodiments of the Invention As a result of extensive studies to achieve the above object, the present inventor has found that a plaster containing a fluorine compound is coated on both surfaces of a support base. The occlusal sheet composition adheres to the pit and fissure entrance due to occlusion, and fluoride is gradually penetrated and supplied into the pit and fissure over a long period of time, thereby suppressing the occurrence and progress of occlusal caries. And found the present invention. Hereinafter, the present invention will be described in more detail. The fluorine-containing sheet of the present invention is obtained by coating a plaster body containing a fluorine compound on both surfaces of a support base, and is prepared for oral occlusion. Is what is done. The plaster can be prepared by kneading a fluorine compound and a binder with water. Examples of the fluorine compound used in the present invention include sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, ammonium fluoride, lithium fluoride and the like. One of these may be used alone or in combination of two or more. The compounding amount of the fluorine compound is
A concentration not exceeding 1000 ppm as fluorine ions is preferred, and 0.5 to 500 ppm is particularly suitable. As the binder, sodium polyacrylate, sodium carboxymethylcellulose, hydroxyethylcellulose, carrageenan, carbopol, guar gum, sodium alginate, cationized cellulose, montmorillonite, gelatin and the like can be blended. The amount of these binders is 0.1 to 0.1
10% (mass percentage, the same applies hereinafter), particularly 1.0 to 5.0
%, The viscosity of the paste at 25 ° C. is 20 to 200 Pa · sec, particularly 50 to 100 Pa
-It is preferable to mix them so as to make them sec. Further, a plastic film, a woven fabric, a non-woven fabric, or the like can be used as a support base of the plaster, and the plaster is coated on both sides of the support base. In this case, the size of the support base is not particularly limited as long as it is suitable for occlusal use.
mm, especially about 50 × 20 mm, and the plaster is 0.5 to 20 mm, especially 2 to 10 m
It is preferable to coat with a thickness of about m so as to give the above-mentioned fluorine ion concentration. The paste of the present invention may contain other additives as optional components in addition to the above essential components. For example, plasters include thickeners, surfactants, sweeteners, preservatives, various active ingredients other than fluorine compounds, pigments,
Perfumes and the like can be blended, and these components can be mixed with water to be produced. As the thickener, sorbit, glycerin, propylene glycol, polyoxyethylene glycol, xylit, maltit, lactit and the like can be incorporated in the paste in an amount of 0.1 to 90%, particularly 10 to 70%. As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like can be blended, and specific examples thereof include sodium lauryl sulfate, sodium α-olefin sulfonate, and N-acyl sulfonate. Cosinate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, pluronic, etc. May be blended. As a sweetener, saccharin sodium,
Stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone,
Preservatives such as perillartin and the like; paraoxybenzoic acid esters and sodium benzoate; and various active ingredients such as dextranase, mutanase, potassium phosphate and orthophosphoric acid, water-soluble phosphate compounds such as sodium salt, allantoinchlorohydroxyl Aluminum, hinokitiol,
Ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocophenol acetate, α
-Bisabolol, isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper copper chlorophyllin sodium,
Copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite, mutanase, dextranase, amylase,
Methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, toque soft extract, oak extract, clove, rosemary, orgon, safflower etc. An extract may be formulated. As fragrances, terpenes such as l-menthol, carvone, anethole, limonene and the like or derivatives thereof, and as a colorant, Blue No. 1, Yellow No. 4, titanium dioxide and the like can be compounded. In addition, the compounding quantity of these components can be each an effective amount. The fluorine-containing sheet of the present invention, by being occluded, effectively penetrates and supplies fluorine to the pit and fissure, which is a site where caries is most likely to occur. The amount of fluorine retained in the pits increases, and the fluorine is supplied deep into the pits and fissures, whereby the occurrence and progress of caries on the occlusal surface can be suppressed. The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, all% in each example is a mass percentage. Example 1, Comparative Example 1 A human extracted molar was immersed in a demineralizing solution to form an artificial initial caries (subsurface demineralization) on the occlusal surface. A human extracted molar having an artificial initial caries was attached to a jaw model, and a fluorine-containing sheet (Example 1) having the following composition was sandwiched between upper and lower molars, and occluded with a load of 30 kg for 3 seconds. Thereafter, the molars were removed from the jaw model, washed in distilled water for 10 seconds, and immersed in artificial saliva containing Ca ions and phosphate ions in a thermostat at 37 ° C. As a comparison, a dentifrice containing human extracted molars was immersed for 3 minutes in a liquid in which a dentifrice containing the same concentration of fluorine (Comparative Example 1) was dispersed in three times the amount of water.
The molars were removed from the jaw model, washed in distilled water for 10 seconds, and immersed in artificial saliva containing Ca ions and phosphate ions in a thermostat at 37 ° C. The above treatment was performed twice a day for 3 weeks and evaluated by the following method. Table 1 shows the results. <Evaluation method> A section of the molar occlusal surface after the treatment for 3 weeks was prepared, and the mineral loss ΔZ was determined from the X-ray photograph. The occlusal surface was determined using the initial value of ΔZ of the untreated molar sample. The artificial initial caries average remineralization rate was calculated. Fluorine-containing sheet (Example 1) Composition: Sodium fluoride 0.1% Sorbit (70%) 30 Fragrance 1.0 Sodium polyacrylate 2.5 Water Remainder 100.0% Absorbs the above plaster Were coated (thickness: 5 mm) on both sides of the nonwoven fabric (50 × 20 mm) of Example 1 to prepare a fluorine-containing sheet. Fluorine-containing dentifrice (Comparative Example 1) Composition: Sodium fluoride 0.1% Silicic anhydride 14 Sodium lauryl sulfate 1.4 Sodium alginate 0.8 Carrageenan 0.8 Sorbit (70%) 30 Saccharin sodium 0.15 Propylene glycol 3 Perfume 1.0 Water Remainder 100.0% From the results in Table 1, it can be seen that the occlusion of the fluorine-containing sheet increases the amount of fluorine retained on the occlusal surface as compared with ordinary toothpaste, and the fluorine is supplied deep into the pit and fissure. It was found that it was possible to suppress the occurrence and progress of occlusal caries. [Example 2] Dentifrice Sodium monofluorophosphate 0.7% Sorbit (70%) 50 Fragrance 1.0 Sodium carboxymethylcellulose 3.0 Sodium lauryl sulfate 0.5 Water Residual total 100.0% The above plaster The body was coated (thickness: 3 mm) on both sides of a plastic film (60 × 30 mm) to produce a fluorine-containing sheet. Example 3 Sodium Fluoride 0.2% Glycerin (85%) 40 Fragrance 0.8 Sodium Alginate 1.5 Yellow No. 4 0.005 Water Remainder Total 100.0% (50 × 20 mm) were coated (thickness: 10 mm) to prepare a fluorine-containing sheet. Example 4 Sodium Fluoride 0.05% Xylit 60 Saccharin Sodium 0.1 Fragrance 1.0 Hydroxyethylcellulose 2.5 Sodium Alginate 1.2 Water Remaining Total 100.0% The above plaster was nonwoven fabric (50 × (20 mm) on both sides (8 mm thick) to produce a fluorine-containing sheet.

   ────────────────────────────────────────────────── ─── Continuation of front page    (72) Inventor Shoji Nakajima             Rio, 1-3-7, Honjo, Sumida-ku, Tokyo             Incorporated F term (reference) 4C076 AA72 BB22 CC16 DD38 EE09                       FF31 FF68                 4C083 AB471 AB472 AC132 AC782                       AD272 BB60 CC41 DD12                       EE01 EE32                 4C086 AA01 AA02 HA24 MA02 MA05                       MA32 MA57 NA12 ZA67

Claims (1)

Claims: 1. A fluorine-containing sheet for oral occlusion, wherein a plaster containing a fluorine compound is coated on both surfaces of a support base.