JP2019214524A - Oral composition - Google Patents

Abstract

To provide toothpaste compositions that can effectively incorporate fluorine ions into the tooth surface to strengthen the tooth quality while exerting the effect of closing an opening of a dentin tubule, and effectively suppress pain and the like for all users who have symptoms of hyperesthesia.SOLUTION: Provided is an oral composition containing the following components (A) to (C): (A) one or two fluorine ion-supplying compounds selected from sodium fluoride and tin fluoride; (B) 0.35 mass% or more and 1.3 mass% or less of calcium glycerophosphate; and (C) 0.5 mass% or more to 6 mass% or less of fatty acid divalent metal salt derived from a saturated fatty acid having 12 or more to 18 or less carbon atoms, the mass ratio ((B)/(C)) between the content of the component (B) and the content of the component (C) being 0.12 or more to 1.5 or less.SELECTED DRAWING: Figure 2

Description

  The present invention relates to oral compositions.

  In healthy teeth, the dentin of a tooth is usually covered with gingiva or enamel of the tooth. However, if gingival regression or damage to tooth enamel occurs due to gingivitis, aging, or improper brushing with excessive load, dentine is exposed on the tooth surface and the dentin surface The nerves are stimulated through the dentinal tubules that are open at the, causing pain and irritation, so-called hyperesthesia. In order to suppress such pain caused by hypersensitivity, it is a direct and effective method to block the opening of the dentin tubule on the surface of the exposed dentin. Is being developed.

  For example, Patent Document 1 discloses a dentifrice composition in which a poorly water-soluble powder selected from a specific fatty acid divalent metal salt, a fatty acid acyl lysine, and a fatty acid acyl taurine divalent metal salt, and a specific desensitizing agent are used together with water. Patent Document 2 discloses a dentin hypersensitivity which contains a desensitizing agent such as potassium nitrate, a specific fatty acid or an alkali metal salt thereof, and water and is adjusted to a specific pH range. A composition for oral cavity for use is disclosed, and any of the compositions can effectively block the opening of the dentin tubule on the surface of the exposed dentin.

JP 2013-1648 A JP-A-2015-124216

  On the other hand, those who are conscious of such hyperesthesia have realized so-called deterioration of the tooth quality, which is expressed by the feeling that the teeth are thin or the teeth are easily applied. Cases are increasing. If the tooth quality deteriorates, cracks and erosion are likely to occur, and tooth fractures are also likely to occur due to impact, etc., which can be indirect factors causing hypersensitivity. . Therefore, in order to suppress pain and the like due to hypersensitivity assuming all situations, not only can the opening of the dentin tubule be closed, but also a composition for the oral cavity that can enhance the dentin It is where the realization of is desired.

  However, although the composition described in Patent Literature 1 exhibits a high sealing ability with respect to the opening of the dentin tubule, no detailed study has been made on strengthening the tooth by taking in fluorine ions. Further, in the composition described in Patent Document 2, in some specific examples, a fluorine ion supplying compound which is a component for promoting remineralization is contained, but supplied fluorine ions are present in the composition such as zinc and the like. Unnecessary metal fluoride salts are formed together with the polyvalent metal, so further improvement is needed to ensure sufficient fluoride ion uptake on the tooth surface and contribute to the strengthening of the tooth. It is in.

  That is, the present invention not only exerts the effect of closing the opening of the dentin tubule, but also strengthens the tooth by effectively taking in fluorine ions not only to the tooth surface but also to the opening of the dentin tubule. The present invention relates to an oral composition capable of effectively and effectively suppressing pain and the like for any user having a hypersensitivity symptom.

  Therefore, the present inventor has conducted intensive studies to solve the above problems, and as a result, while containing a specific fluorine ion supplying compound, a fatty acid divalent metal salt is used together with calcium glycerophosphate at a specific content and a specific mass ratio. By doing so, it has been found that an oral composition which can sufficiently combine the effect of closing the opening of the dentin tubule with the effect of strengthening the dentin can be obtained.

Accordingly, the present invention provides the following components (A) to (C):
(A) One or two kinds of fluorine ion supplying compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass to 1.3% by mass (C) C12 to C18 A fatty acid divalent metal salt derived from a saturated fatty acid of 0.5 to 6% by mass, and a mass ratio of the content of the component (B) to the content of the component (C) ((B) / (C)) is 0.12 or more and 1.5 or less.

According to the composition for oral cavity of the present invention, not only can the opening of the dentin tubule on the surface of the exposed dentin be effectively blocked, but also the fluorine ion can reach the tooth surface and the opening of the dentin tubule. It is possible to effectively increase the incorporation of the tooth, effectively enhance the tooth quality, and effectively suppress pain and irritation caused by hyperesthesia.
Therefore, by using the composition for oral cavity of the present invention, not only the user whose dentin of the teeth is exposed due to the regression of the gingiva due to the progress of gingivitis or aging, etc., as well as the enamel of the teeth Even for users who have dentin exposed due to damage of the teeth, it can promote remineralization and strengthen the dentin while closing the opening of the dentin tubule Therefore, it is possible to effectively alleviate the symptoms of hypersensitivity in various situations.

9 is a photograph showing an opening of a dentin tubule before using the dentifrice composition of Example 7. 9 is a photograph showing a state in which the opening of the dentin tubule is closed after using the dentifrice composition of Example 7.

Hereinafter, the present invention will be described in detail.
The oral composition of the present invention comprises the following components (A) to (C):
(A) One or two kinds of fluorine ion supplying compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass to 1.3% by mass (C) C12 to C18 A fatty acid divalent metal salt derived from a saturated fatty acid of 0.5 to 6% by mass, and a mass ratio of the content of the component (B) to the content of the component (C) ((B) / (C)) is 0.12 or more and 1.5 or less.
The oral composition of the present invention may be used as a dentifrice composition such as a toothpaste or a dentifrice, or as a liquid oral composition such as a mouthwash or a liquid dentifrice, depending on the intended use. It is a composition which can be.
In the present invention, "to block the opening of the dentin tubule" means to physically block the dentin tubule, and only to cover the opening of the dentin tubule on the surface of the dentin. In other words, the term also includes a state in which the capillaries are filled (closed) with filling in capillaries near the surface of the dentin capillaries.

  The composition for oral cavity of the present invention contains, as component (A), one or two kinds of fluorine ion supplying compounds selected from sodium fluoride and tin fluoride. The component (A) releases fluorine ions when the oral composition of the present invention is applied to the oral cavity, and the fluorine ions are effective and efficient together with calcium ions released from the component (B) described below. Calcium fluoride particles can be formed while miniaturization is achieved. The finely divided calcium fluoride can be efficiently adsorbed to the tooth surface and the dentin tubule without impairing the sealing ability of the opening of the dentin tubule, so that the fluorine ion adsorption amount is effectively increased. This promotes remineralization of the teeth, and can exert an excellent effect on strengthening the tooth quality.

The content of the component (A) is preferably 0 in the oral composition of the present invention from the viewpoint of effectively increasing the fluoride ion adsorption rate to the tooth surface and the dentin tubule in combination with the component (B) described later. 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.15% by mass or more, even more preferably 0.25% by mass or more. In addition, the content of the component (A) increases the fluorine ion adsorption rate to the tooth surface and the dentin tubule efficiently, and from the viewpoint of not unnecessarily reducing the ability to seal the opening of the dentin tubule. In the oral composition of the present invention, it is preferably 1% by mass or less, more preferably 0.8% by mass or less, further preferably 0.5% by mass or less, and still more preferably 0.4% by mass or less. % Or less. The content of the component (A) in the oral composition of the present invention is preferably 0.01% by mass or more and 1% by mass or less, more preferably 0.1-0.8% by mass, More preferably, it is 0.15 to 0.5% by mass, and even more preferably, it is 0.25 to 0.4% by mass.
From the same viewpoint as described above, the fluorine atom-converted amount of the component (A) is preferably 0.005% by mass or more, more preferably 0.05% by mass or more in the oral composition of the present invention. It is still more preferably at least 0.07% by mass, and even more preferably at least 0.11% by mass. From the same viewpoint as described above, the amount of the component (A) in terms of fluorine atoms in the oral composition of the present invention is preferably 0.4% by mass or less, more preferably 0.35% by mass or less. Yes, more preferably 0.25% by mass or less, even more preferably 0.2% by mass or less. The amount of the component (A) in terms of fluorine atom in the oral composition of the present invention is preferably 0.005 to 0.4% by mass, more preferably 0.05 to 0.35% by mass. Yes, more preferably 0.07 to 0.25% by mass, and even more preferably 0.11 to 0.2% by mass.

  The composition for oral cavity of the present invention contains 0.35% by mass or more and 1.3% by mass or less of calcium glycerophosphate as the component (B). Thereby, the unnecessary calcium salt which does not inhibit the ability of the oral composition of the present invention to seal the opening of the dentin tubule and inhibits the adsorption of fluoride ions to the tooth surface and the dentin tubule In combination with the fluoride ions released from the component (A), it is possible to effectively and effectively increase the fluorine ion adsorption rate on the tooth surface and the dentin tubule while effectively suppressing the formation of the cations.

  The content of the component (B) is combined with the component (A) to form fine calcium fluoride particles, and to effectively and effectively increase the amount of fluoride ions adsorbed on the tooth surface and the dentin tubule, thereby increasing the dentin content. From the viewpoint of enhancing the content, in the oral composition of the present invention, the content is 0.35% by mass or more, preferably 0.44% by mass or more, more preferably 0.46% by mass or more. It is preferably at least 0.48% by mass. In addition, the content of the component (B) is determined in the oral composition of the present invention from the viewpoint that the amount of fluoride ion adsorbed on the tooth surface and the dentin tubule and the ability to block the opening of the dentin tubule are not unnecessarily reduced. 1.3 mass% or less, preferably 1.1 mass% or less, more preferably 0.85 mass% or less, and still more preferably 0.7 mass% or less. The content of the component (B) in the composition for oral cavity of the present invention is 0.35% by mass or more and 1.3% by mass or less, and preferably 0.44% to 1.1% by mass. , More preferably 0.46 to 0.85% by mass, and still more preferably 0.48 to 0.7% by mass.

  The mass ratio ((A) / (B)) between the fluorine atom-converted amount of the component (A) and the content of the component (B) in the oral composition of the present invention is determined by the fluorine ion of the component (A) and the component (A). From the viewpoint of forming finely divided calcium fluoride particles composed of calcium ions released from B) on the tooth surface and in the dentin tubules, and effectively increasing the amount of fluoride ions adsorbed to strengthen the tooth, preferably, It is 0.12 or more, more preferably 0.2 or more, further preferably 0.23 or more, and still more preferably 0.26 or more. In addition, the mass ratio ((A) / (B)) between the fluorine atom equivalent of the component (A) and the content of the component (B) in the oral composition of the present invention is preferably 0 from the same viewpoint. 0.8 or less, more preferably 0.6 or less, further preferably 0.4 or less, and still more preferably 0.35 or less. The mass ratio ((A) / (B)) between the fluorine atom equivalent of the component (A) and the content of the component (B) in the oral composition of the present invention is preferably 0.12 to 0.1. 8, more preferably 0.2 to 0.6, further preferably 0.23 to 0.4, and still more preferably 0.26 to 0.35.

  The oral composition of the present invention contains, as component (C), a fatty acid divalent metal salt derived from a saturated fatty acid having 12 to 18 carbon atoms in an amount of 0.5% by mass to 6% by mass. Thus, in combination with the above-mentioned components, the amount of fluoride ions taken up on the tooth surface and the dentin tubule is effectively and effectively increased, thereby enhancing the tooth quality and exhibiting an excellent sealing ability of the opening of the dentin tubule. Thus, pain or the like due to hyperesthesia can be sufficiently suppressed.

  The component (C) is a component composed of two saturated fatty acids and a divalent metal. Specific examples of such saturated fatty acids include lauric acid, myristic acid, pentadecylic acid, palmitic acid, margaric acid, and One or more selected from stearic acid may be mentioned. Above all, lauric acid, myristic acid, and stearic acid are preferable, and stearic acid is more preferable, and two saturated fatty acids constituting the component (C) are preferably the same. Furthermore, specific examples of the divalent metal include one or more selected from zinc, calcium, magnesium, strontium, and barium. Among them, from the viewpoint of applicability to the oral cavity, and spreadability that contributes to excellent sealing ability of the opening of the dentin tubule, one or more selected from zinc, calcium, and magnesium are preferable, and zinc is preferred. Is more preferred.

  The content of the component (C) is to form fine calcium fluoride particles composed of fluorine ions of the component (A) and calcium ions released from the component (B) on the tooth surface and in the dentin tubule. From the viewpoint of enhancing the effect of suppressing pain and the like while further enhancing the excellent sealing ability of the opening of the dentin tubule, the composition for oral cavity of the present invention contains 0.5% by mass or more, preferably 1% by mass. It is at least 0.5% by mass, more preferably at least 1.7% by mass, even more preferably at least 1.8% by mass. In addition, the content of the component (C) does not inhibit the increase in the amount of fluoride ions adsorbed on the tooth surface and the dentin tubule due to the calcium fluoride particles fined by the components (A) and (B). From the viewpoint of effectively enhancing the tooth quality and avoiding the appearance of off-flavors such as metallic tastes and ensuring good flavor of the composition, the oral composition of the present invention contains 6% by mass or less. It is preferably 5% by mass or less, more preferably 4.5% by mass or less, and still more preferably 4% by mass or less. The content of the component (C) in the composition for oral cavity of the present invention is 0.5% by mass or more and 6% by mass or less, preferably 1.5 to 5% by mass, more preferably It is 1.7 to 4.5% by mass, and more preferably 1.8 to 4% by mass.

  The mass ratio ((A) / (C)) between the fluorine atom-converted amount of the component (A) and the content of the component (C) in the oral composition of the present invention is such that the fluorine ion of the component (A) and the component (A) From the viewpoint of forming finely divided calcium fluoride particles composed of calcium ions released from B) on the tooth surface and in the dentin tubules, and effectively increasing the amount of fluoride ions adsorbed to strengthen the tooth, preferably, It is 0.01 or more, more preferably 0.02 or more, and further preferably 0.03 or more. The mass ratio ((A) / (C)) between the fluorine atom equivalent of the component (A) and the content of the component (C) in the oral composition of the present invention is preferably 0 from the same viewpoint. 0.3 or less, more preferably 0.2 or less, and even more preferably 0.15 or less. The mass ratio ((A) / (C)) between the fluorine atom equivalent of the component (A) and the content of the component (C) in the oral composition of the present invention is preferably 0.01 to 0.1. 3, more preferably 0.02 to 0.2, and still more preferably 0.03 to 0.15.

The mass ratio ((B) / (C)) between the content of the component (B) and the content of the component (C) in the composition for oral cavity of the present invention suppresses aggregation of the component (B), and From the viewpoint of effectively and effectively increasing the adsorption of the finely divided calcium fluoride particles on the surface and in the dentin tubules and the fluoride ion adsorption amount to strengthen the tooth, it is preferably 0.12 or more, preferably The mass ratio ((B) / (C)) between the content of the component (B) and the content of the component (C) is 0.14 or more, more preferably 0.24 or more. From the viewpoint of not unnecessarily reducing the amount of fluoride ions adsorbed on the surface and the dentin tubule and the ability to seal the opening of the dentin tubule, it is 1.5 or less, preferably 1.0 or less, more preferably 0 or less. 0.6 or less, and more preferably 0.35 or less. The mass ratio ((B) / (C)) between the content of the component (B) and the content of the component (C) in the oral composition of the present invention is 0.12 or more and 1.5 or less, Preferably it is 0.12-1.0, More preferably, it is 0.14-0.6, More preferably, it is 0.24-0.35.
As a result, in addition to the progress of gingivitis and aging, inadequate brushing that overloads, etc., causes gingival regression and damage to the enamel of the tooth, resulting in dentin exposure as well as cavities. In a wide variety of use environments including the occurrence of tooth fractures due to impact and the like and the occurrence of wedge-shaped defects due to malocclusion, in addition to the occurrence of cracks and corrosion, the opening of dentin tubules with the oral composition of the present invention And the effect of effectively promoting remineralization to strengthen the tooth can be achieved, and pain and the like due to hyperesthesia can be effectively suppressed.

  The oral composition of the present invention preferably contains one or more desensitizing agents (D) selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate. By containing such a component (D), it is possible to remove hypersensitivity of the nerve or desensitize the nerve to further enhance the effect of suppressing pain and the like caused by the ability to block the opening of the dentin tubule. it can. Of these, potassium nitrate is preferred.

  The content of the component (D) is preferably 1% by mass or more in the oral composition of the present invention from the viewpoint of further enhancing the effect of suppressing hyperalgesia and other pains in combination with the component (C). , More preferably 2% by mass or more, and still more preferably 3% by mass or more. Further, the content of the component (D) is preferably 15% by mass or less, more preferably 10% by mass, in the oral composition of the present invention, from the viewpoint of the effect of suppressing pain due to hyperesthesia and the like and the economic efficiency. % By mass or less, more preferably 8% by mass or less.

  Among them, when potassium nitrate is used as the component (D), the mass ratio ((C) / (potassium nitrate)) between the content of the component (C) and the content of the potassium nitrate in the oral composition of the present invention is hypersensitive. From the viewpoint of further enhancing the effect of suppressing pain and the like due to illness, it is preferably at least 0.3, more preferably at least 0.4, even more preferably at least 0.5, and preferably at most 1.0. Yes, more preferably 0.9 or less, even more preferably 0.85 or less.

  When the oral composition of the present invention is a dentifrice composition, further, an alkyl sulfate salt such as sodium lauryl sulfate, an N-acyl amino acid salt, an alkyl phosphate, a higher fatty acid sulfonated monoglyceride salt, and a fatty acid ester of isethionic acid It is preferable to contain an anionic surfactant such as salt, N-long-chain acyltaurine sodium salt, and polyoxyethylene monoalkyl phosphate. Among them, alkyl sulfate ester salt, N-long-chain acyltaurine sodium salt, from the viewpoint of imparting good foaming and feeling of use, and ensuring the retention of the composition in the oral cavity and the adsorbability or adhesion to the tooth surface, Is more preferable, and it is further preferable to use them in combination.

  More specifically, the content of the anionic surfactant in the oral composition of the present invention is preferably at least 0.2% by mass, more preferably at least 0.4% by mass, even more preferably. Is 0.6% by mass or more, preferably 1.5% by mass or less, more preferably 1.2% by mass or less, and still more preferably 1% by mass or less.

Further, when the oral composition of the present invention contains an anionic surfactant, it suppresses salt exchange with potassium nitrate, secures retention and adhesion while providing good foam quality, and opens dentin tubules. From the viewpoint of effectively achieving both the effect of closing the part and the effect of promoting remineralization to strengthen the tooth, it is preferable that the content of the alkyl sulfate is a specific content.
More specifically, the content of the alkyl sulfate in the content of the anionic surfactant is preferably 1 to 50% by mass, more preferably 5 to 30% by mass, and still more preferably 10 to 30% by mass. -20% by mass or less.

The oral composition of the present invention reinforces the expression of good foaming and feeling of use, further enhances the retention of the composition in the oral cavity and the adsorptivity or adhesion to the tooth surface, and enhances the opening of the dentin tubule. It is preferable to contain a nonionic surfactant, from the viewpoint of ensuring both the effect of blocking odor and the effect of promoting remineralization and strengthening the dentin. As such nonionic surfactants, specifically, for example, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, alkyl glucoside, Examples include polyglycerin fatty acid ester, polyoxyethylene monoalkyl (or alkenyl) ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, fatty acid alkanolamide, polyglycol, and the like. Among them, polyoxyethylene hydrogenated castor oil is preferable, and it is preferable to use it in combination with the above-mentioned anionic surfactant.
More specifically, the content of the nonionic surfactant in the oral composition of the present invention is preferably 1% by mass or less, more preferably 0.8% by mass or less, and further preferably 0% by mass or less. 0.7% by mass or less, preferably 0.1% by mass or more, more preferably 0.2% by mass or more, still more preferably 0.3% by mass or more. Furthermore, the mass ratio of the content of the anionic surfactant to the content of the nonionic surfactant (anionic surfactant / nonionic surfactant) is preferably 1 to 2, and more preferably 1 to 1.6. It is.

  When the oral composition of the present invention is a dentifrice composition, it may further contain a binder. Such binders include one or more selected from xanthan gum, sodium carboxymethylcellulose, sodium alginate, carrageenan, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, and the like. No. Among them, xanthan gum and sodium carboxymethylcellulose are preferred, and xanthan gum is more preferred.

  The content of such a binder exerts good foam quality and foam retention while maintaining appropriate shape retention, and secures the retention property of the composition in the oral cavity and the adsorptivity or adhesion to the tooth surface. Accordingly, it is preferable to limit the amount to an appropriate amount from the viewpoint of effectively achieving both the effect of closing the opening of the dentin tubule and the effect of promoting remineralization and strengthening the dentin. Specifically, the content of the binder in the oral composition of the present invention is preferably 4% by mass or less, more preferably 3% by mass or less, and preferably 2% by mass or more. . When xanthan gum is used, the content of the xanthan gum in the oral composition of the present invention is preferably 0.5% by mass or less, more preferably 0.3% by mass or less, and preferably 0% by mass or less. .15% by mass or more.

Among such binders, while maintaining a suitable shape retention property, it exhibits even better foam quality and foam retention to improve the retention of the composition in the oral cavity and the adsorptivity or adhesion to the tooth surface. From the viewpoint of securing, it is preferable to contain a thickening silica. Such thickening silica is silica having a large oil absorption, and is different from abrasive silica used as an abrasive. Generally, the thickening silica has an oil absorption of 200 to 400 mL / 100 g, and the abrasive silica has an oil absorption of 50 to 150 mL / 100 g. Here, the oil absorption indicates the amount of oil that can be carried by the silica. The measuring method is specified by the method of JIS K 5101-13-2 (established in 2004) and the amount of oil absorbed by boiling oil. Means the values of thyricia, silopure (manufactured by Fuji Silysia Chemical), thixosil (manufactured by Rhodia), sorbosil (manufactured by Ineos Silica), fine seal (manufactured by Tokuyama), and nip gel (manufactured by Tosoh Silica) Commercial products can be used.
More specifically, the content of the thickening silica in the oral composition of the present invention is preferably 1 to 10% by mass, more preferably 2 to 8% by mass, and still more preferably 3 to 8% by mass. 6% by mass.

  The oral composition of the present invention makes the calcium fluoride particles formed by the component (A) and the component (B) finer more effectively, and does not hinder the ability to block the opening of the dentin tubule. From the viewpoint of increasing the amount of fluorine adsorbed on the surface, it is preferable to further contain xylitol. The content of such xylitol in the oral composition of the present invention is preferably 3% by mass or more, more preferably 8% by mass or more, preferably 25% by mass or less, more preferably 20% by mass or less. % Or less.

In the oral cavity composition of the present invention, from the viewpoint of inhibiting the formation of fine calcium fluoride particles by the components (A) and (B), the content of the fatty acid is preferably limited. The fatty acid preferably has 18 or less carbon atoms, more preferably 16 or less carbon atoms, and preferably has a hydrocarbon group with 12 or more carbon atoms. Specific examples include lauric acid, myristic acid, palmitic acid, stearic acid and the like.
The content of the fatty acid in the oral composition of the present invention is preferably 0.3% by mass or less, more preferably 0.1% by mass or less, and further preferably 0.05% by mass or less. Yes, or the oral compositions of the present invention preferably do not contain fatty acids.

The oral composition of the present invention does not impair the effect of suppressing pain or the like due to hyperesthesia, and provides a good feeling of use while eliminating as much as possible a factor that induces the development of new pain and the like. It is preferable to limit the content of the abrasive from the viewpoint of maintaining the adsorbability and adhesion by maintaining foaming and the like. Specific examples of such abrasives include abrasive silica, dibasic calcium phosphate monohydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum oxide, aluminum hydroxide, magnesium acetate, and dibasic magnesium phosphate. , Tribasic magnesium phosphate, zeolite and the like.
The content of such an abrasive is preferably 10% by mass or less, more preferably 8% by mass or less, and still more preferably 4% by mass or less in the oral composition of the present invention.

  The oral composition of the present invention contains water. Such water includes not only purified water and the like blended in the oral composition, but also water contained in each blended component such as a 70% sorbitol solution (aqueous solution) used in the formulation. Means the total moisture contained in the composition. By containing such water, the component (A) and the component (B) can be favorably dissolved or dispersed to form finer calcium fluoride particles on the tooth surface more effectively, and the desired effect can be obtained. Can be fully exhibited.

For example, when the oral composition of the present invention is a dentifrice composition, the content of water in the oral composition of the present invention is preferably 5% by mass or more, more preferably 15% by mass or more. And preferably 95% by mass or less, more preferably 80% by mass or less. In addition, the content of water in the oral composition of the present invention is preferably 5 to 95% by mass, and more preferably 15 to 80% by mass.
In this case, the water content can be calculated from the blended water content and the moisture content in the blended components, but can be measured by, for example, a Karl Fischer moisture meter. As the Karl Fischer moisture meter, for example, a trace moisture measuring device (Hiranuma Sangyo Co., Ltd.) can be used. In this apparatus, 5 g of the composition for oral cavity is taken, suspended in 25 g of anhydrous methanol, and 0.02 g of the suspension is taken to measure the water content.

  When the oral composition of the present invention is a liquid oral composition, the content of water in the oral composition of the present invention is preferably 8% by mass or more, more preferably 10% by mass. And more preferably 12% by mass or more, preferably 50% by mass or less, more preferably 45% by mass or less, and still more preferably 40% by mass or less. Further, the content of water in the oral composition of the present invention is preferably 8 to 50% by mass, more preferably 10 to 45% by mass, and still more preferably 12 to 40% by mass.

The oral composition of the present invention further includes a cationic surfactant, a monofluorophosphate ion-supplying compound such as sodium monofluorophosphate and potassium monofluorophosphate, as long as the effects of the present invention are not impaired; glycerin, polyethylene Glycols, wetting agents and sweeteners; sugar alcohols other than xylitol, such as sorbitol; pH adjusters, such as sodium hydrogen phosphate; fragrances; quaternary ammonium compounds, biguanide compounds, isopropylmethylphenol, triclosan, thymol, and β- It may contain a medicinal ingredient such as glycyrrhetinic acid and other active ingredients; a fragrance; a pigment, and the like.
In addition, when the oral composition of the present invention is a dentifrice composition, it preferably contains propylene glycol from the viewpoint of increasing the amount of fluorine adsorbed on the tooth surface. The content of propylene glycol in the oral composition of the present invention is preferably 1 to 20% by mass, and more preferably 5 to 15% by mass.

When the oral composition of the present invention is a dentifrice composition, the viscosity at 25 ° C. of the oral composition is such that the composition retains in the oral cavity while maintaining an appropriate shape-retaining property and is adsorbed on the tooth surface. From the viewpoint of ensuring both the effect of closing the opening of the dentin tubule and the effect of promoting remineralization and strengthening the tooth by ensuring the properties or adhesion, preferably at 1500 dPa · s or more. Yes, more preferably 2000 dPa · s or more, still more preferably 2300 dPa · s or more, preferably 3500 dPa · s or less, more preferably 3000 dPa · s or less, and still more preferably 2700 dPa · s or less. .
The viscosity at 25 ° C. means a value measured using a helipath type viscometer. Specifically, the viscosity of an oral composition left at room temperature (25 ° C.) for at least 24 hours after production is measured. After filling in a container for measurement and storing for 24 hours in a thermostat at 25 ° C., using a helipath type viscometer (VISCOMMETER TVB-10 Toki Sangyo), 25 ° C., rotor TC, rotation speed 2.5 rpm, The measurement can be performed for one minute.

When the oral composition of the present invention is a dentifrice composition, the rotational viscosity of such an oral composition at 25 ° C. using a cylindrical rotor is preferably 2500 dPa · s or more from the same viewpoint. And more preferably 3000 dPa · s or more, further preferably 3300 dPa · s or more, preferably 4500 dPa · s or less, more preferably 4000 dPa · s or less, and still more preferably 3700 dPa · s or less.
The rotational viscosity at 25 ° C. using a cylindrical rotor is measured at 25 ° C., a B8H type viscometer (Toki Sangyo TVB-10R), a rotor H7, a rotational speed of 2.5 rpm for 1 minute. Means the value. The above-mentioned rotor H7 has a cylindrical shape, and has an area in which a diameter of a part of a single cylindrical shape is reduced, and is different in shape from a rotor having a disk shape for measuring a liquid or gel-like composition. . The rotational viscosity using the above-mentioned cylindrical rotor is a value measured in consideration of viscosity, hardness, degree of elongation, and the like. It is considered to be suitable as an index for evaluating according to the adhesiveness of the particles.

  The method for applying the oral composition of the present invention to the oral cavity, when the composition is a liquid oral composition, after sufficiently containing the oral cavity and spreading in the oral cavity, may be used by taking it out of the mouth, When the oral composition of the present invention is a dentifrice composition, it may be applied or brushed with a toothbrush. Further, from the viewpoint of sufficiently exhibiting the effect of closing the opening of the dentin tubule and the effect of promoting remineralization and strengthening the dentin and effectively suppressing pain and the like due to hyperesthesia, the oral cavity of the present invention The frequency of use of the composition for use is preferably 1 to 5 times a day, and is preferably continued for one or more days or 1 to 2 weeks in a month.

With respect to the above-described embodiments, the present invention further discloses the following oral compositions.
[1] The following components (A) to (C):
(A) One or two kinds of fluorine ion supplying compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass to 1.3% by mass (C) C12 to C18 A fatty acid divalent metal salt derived from a saturated fatty acid of 1.5 to 6% by mass, and a mass ratio of the content of the component (B) to the content of the component (C) ((B) / (C)) is 0.12 or more and 1.5 or less.
[2] The content of the component (A) is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, further preferably 0.15% by mass or more, and still more preferably Is 0.25% by mass or more, preferably 1% by mass or less, more preferably 0.8% by mass or less, further preferably 0.5% by mass or less, and still more preferably 0.4% by mass or less. The composition for oral cavity according to the above [1], which is not more than mass%.
[3] The fluorine atom equivalent of the component (A) is preferably at least 0.005% by mass, more preferably at least 0.05% by mass, even more preferably at least 0.07% by mass, It is still more preferably 0.11% by mass or more, preferably 0.4% by mass or less, more preferably 0.35% by mass or less, further preferably 0.25% by mass or less, and further more The oral composition according to the above [1] or [2], which is preferably 0.2% by mass or less.
[4] The content of the component (B) is preferably 0.44% by mass or more, more preferably 0.46% by mass or more, still more preferably 0.48% by mass or more, and preferably 1% or more. 0.1% by mass or less, more preferably 0.85% by mass or less, still more preferably 0.7% by mass or less, for the oral composition of any one of the above [1] to [3].
[5] The mass ratio ((A) / (B)) between the fluorine atom equivalent of the component (A) and the content of the component (B) is preferably at least 0.12, more preferably 0.2. Or more, more preferably 0.23 or more, still more preferably 0.26 or more, preferably 0.8 or less, more preferably 0.6 or less, and still more preferably 0.4 or less. The composition for oral cavity according to any one of [1] to [4] above, more preferably 0.35 or less.

[6] The saturated fatty acid constituting the component (C) is preferably one or more selected from lauric acid, myristic acid, pentadecylic acid, palmitic acid, margaric acid, and stearic acid, and more preferably lauric acid. The oral composition according to any one of the above [1] to [5], which is an acid, myristic acid, or stearic acid, and more preferably stearic acid.
[7] The divalent metal constituting the component (C) is one or more selected from zinc, calcium, magnesium, strontium, and barium, and preferably one selected from zinc, calcium, and magnesium. Or two or more kinds, more preferably zinc, the composition for oral cavity according to any one of the above [1] to [6].
[8] The content of the component (C) is preferably 1.5% by mass or more, more preferably 1.7% by mass or more, still more preferably 1.8% by mass or more, and preferably 5% by mass or more. The oral composition according to any one of the above [1] to [7], wherein the composition is not more than 4.5% by mass, more preferably not more than 4.5% by mass, and still more preferably not more than 4% by mass.
[9] The mass ratio ((B) / (C)) between the content of the component (B) and the content of the component (C) is preferably 0.14 or more, more preferably 0.24 or more. The oral composition according to any one of the above [1] to [8], wherein the composition is preferably 1.0 or less, more preferably 0.6 or less, and still more preferably 0.35 or less.
[10] The mass ratio ((A) / (C)) between the fluorine atom equivalent of the component (A) and the content of the component (C) is preferably 0.01 or more, and more preferably 0.02 or more. [1] to [9] above, more preferably 0.03 or more, preferably 0.3 or less, more preferably 0.2 or less, and still more preferably 0.15 or less. Any one of the oral compositions.
[11] The oral cavity according to any one of the above [1] to [10], further comprising one or more desensitizing agents (D) selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate. Composition.
[12] The oral composition of the above-mentioned [11], wherein the content of the component (D) is preferably 15% by mass or less, more preferably 10% by mass or less, and still more preferably 8% by mass or less.
[13] It contains potassium nitrate as the component (D), and the mass ratio ((C) / (potassium nitrate)) between the content of the component (C) and the content of the potassium nitrate is preferably 0.3 or more; It is more preferably 0.4 or more, further preferably 0.5 or more, preferably 1.0 or less, more preferably 0.9 or less, and further preferably 0.85 or less. 1] to [12] The composition for oral cavity according to any one of [1] to [12].

[14] The content of the nonionic surfactant is preferably 1% by mass or less, more preferably 0.8% by mass or less, further preferably 0.7% by mass or less, and preferably 0.1% by mass or less. The composition for oral cavity according to any one of the above [1] to [13], which is at least 0.2% by mass, more preferably at least 0.2% by mass, and still more preferably at least 0.3% by mass.
[15] It contains xylitol, and such a content is preferably 3% by mass or more, more preferably 8% by mass or more, preferably 25% by mass or less, and more preferably 20% by mass or less. The oral composition according to any one of the above [1] to [14].
[16] The content of the fatty acid is preferably 0.3% by mass or less, more preferably 0.1% by mass or less, further preferably 0.05% by mass or less, or the above-mentioned one containing no fatty acid. [1] The composition for oral cavity of any one of [15].

[17] The oral composition according to any one of the above [1] to [16], which is a liquid oral composition.
[18] The water content is preferably 8% by mass or more, more preferably 10% by mass or more, further preferably 12% by mass or more, preferably 50% by mass or less, more preferably The composition for oral cavity according to the above [17], wherein the composition is 45% by mass or less, more preferably 40% by mass or less.

[19] The oral composition according to any one of [1] to [16], which is a dentifrice composition.
[20] The content of the anionic surfactant is preferably 0.2% by mass or more, more preferably 0.4% by mass or more, still more preferably 0.6% by mass or more, and preferably 1% by mass or more. 0.5% by mass or less, more preferably 1.2% by mass or less, still more preferably 1% by mass or less, and the content of the alkyl sulfate is preferably in the content of the anionic surfactant. Is from 1 to 50% by mass, more preferably from 5 to 30% by mass, even more preferably from 10 to 20% by mass.
[21] The above-mentioned [19] or [20] which contains a binder and has a content of preferably 4% by mass or less, more preferably 3% by mass or less, and preferably 2% by mass or more. Oral composition.
[22] The binder is preferably one or two selected from xanthan gum, sodium carboxymethylcellulose, sodium alginate, carrageenan, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum and the like. Or more, more preferably xanthan gum and sodium carboxymethylcellulose, and still more preferably xanthan gum.
[23] The above-mentioned [19] to [22] in which the content of the thickening silica is preferably 1 to 10% by mass, more preferably 2 to 8% by mass, and still more preferably 3 to 6% by mass. Any one of the oral compositions.
[24] The above-mentioned [19], wherein the content of water is preferably 5% by mass or more, more preferably 15% by mass or more, preferably 95% by mass or less, and more preferably 80% by mass or less. To [23] The oral composition according to any one of the above.
[25] The oral composition according to any one of the above [19] to [24], which contains propylene glycol and preferably has a content of 1 to 20% by mass, more preferably 5 to 15% by mass. .
[26] The viscosity at 25 ° C. is preferably 1500 dPa · s or more, more preferably 2000 dPa · s or more, further preferably 2300 dPa · s or more, preferably 3500 dPa · s or less, more preferably The oral composition according to any one of the above [19] to [25], wherein the composition is 3000 dPa · s or less, more preferably 2700 dPa · s or less.

[27] Use of the oral composition of any one of [1] to [26] for closing an opening of a dentin tubule.
[28] Use of the oral composition of any one of the above [1] to [26] for strengthening the tooth structure.
[29] A method for closing an opening in a dentin tubule, wherein the oral composition according to any one of the above [1] to [26] is applied to a tooth.

[30] The oral composition of the present invention has the following components (A) to (C) from the viewpoint of effectively increasing the fluorine ion adsorption rate to the tooth surface and the dentin tubule:
(A) One or two kinds of fluorine ion supplying compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass to 1.3% by mass (C) C12 to C18 A fatty acid divalent metal salt derived from a saturated fatty acid of 0.5 to 6% by mass, and a mass ratio of the component (A) equivalent to the fluorine atom and the content of the component (B) (( A) / (B)) is 0.12 or more and 0.8 or less, and the mass ratio ((B) / (C)) between the content of the component (B) and the content of the component (C) is 0.1. Most preferably, it is 14 or more and 0.6 or less.

  Hereinafter, the present invention will be specifically described based on examples. Unless otherwise indicated in the table, the content of each component indicates mass%.

[Examples 1 to 7, Comparative Examples 1 to 8]
According to the formulation shown in Table 1, predetermined components were mixed by a conventional method to prepare each liquid oral composition.
Next, using the obtained liquid oral cavity composition, the fluorine ion uptake rate on the HAP surface was determined according to the following method.
The results are shown in Table 1.

<< Fluorine ion uptake rate on HAP surface >>
HAP pellets (APP-100 HOYA) 10 mm × 10 mm × 2 mm were immersed in 20 mL of a 4 × diluted solution of the obtained liquid oral composition, immersed for 3 minutes, and then the liquid oral composition was removed with ion-exchanged water. To dry the pellet. Extraction of fluorine ions from the dried pellets with 1N hydrochloric acid for 30 seconds, and using a fluoride ion electrode (ionplus20Fluoride (manufactured by ORION)) and an ion analyzer (Expandable ionAnalyzer EA 940 (manufactured by ORION)) for HAP. The amount of fluorine adsorbed on the pellet was determined as the amount of fluorine ion taken up.
On the basis of the fluorine atom conversion amount of the component (A) used when each liquid oral composition was prepared, the fluorine ion uptake rate on the HAP surface was determined based on the obtained fluorine ion uptake value (100%). %) Was calculated. The larger the value is, the larger the fluorine ion uptake amount is, and the more excellent the tooth reinforcement is.

[Examples 8 to 10, Comparative Examples 9 to 12]
According to the prescription shown in Table 2, predetermined components were mixed by a conventional method to prepare each dentifrice composition.
Next, using the obtained dentifrice composition, measurement and evaluation were performed according to the following methods.
The results are shown in Table 2.

<< Measurement of helipath viscosity >>
After the production, the dentifrice composition left standing at room temperature (25 ° C.) for 24 hours is packed in a container for measuring viscosity and stored in a thermostat at 25 ° C. for 24 hours, and then a helipath viscometer (VISCOMMETER TVB-10 Toki Sangyo). Was measured under the conditions of a rotor TC, a rotation speed of 2.5 rpm, and 1 minute.

<< Measurement of B8H viscosity >>
The rotational viscosity of the obtained dentifrice composition was measured under the conditions of a B8H type viscometer (Toki Sangyo TVB-10R), a rotor H7, a rotational speed of 2.5 rpm and 1 minute.

<< Fluorine ion uptake rate on HAP surface >>
2.5 g of the obtained dentifrice composition was diluted 4-fold with ion-exchanged water to obtain 10 g of each sample. Then, HAP pellets (APP-100 HOYA) 10 mm × 10 mm × 2 mm were immersed in a four-fold dilution of each sample and immersed for 3 minutes, then the dentifrice composition was removed with ion-exchanged water, and the pellets were dried. Extraction of fluorine ions from the dried pellets with 1N hydrochloric acid for 30 seconds, and using a fluoride ion electrode (ionplus20Fluoride (manufactured by ORION)) and an ion analyzer (Expandable ionAnalyzer EA 940 (manufactured by ORION)) for HAP. The amount of fluorine adsorbed on the pellet was determined as the amount of fluorine ion taken up.
Based on the fluorine atom conversion amount of the component (A) used when preparing each dentifrice composition as a 100% standard, the fluorine ion uptake rate (%) on the HAP surface based on the obtained fluorine ion uptake value. Was calculated. The larger the value is, the larger the fluorine ion uptake amount is, and the more excellent the tooth reinforcement is.

《Evaluation of improvement of pain caused by hyperesthesia》
The resulting dentifrice composition was evaluated for the degree of prevention or suppression of pain caused by hypersensitivity to dentin due to long-term use. As subjects to be evaluated (panelers), those who had daily teething during the last month or those who had at least once a week were employed. Eighty-nine panelists evaluated whether the pain due to hyperesthesia was prevented or suppressed after using each dentifrice composition two to three times a day for two weeks.
The evaluation criteria were as follows: "Improving effect of squeezing pain" after continuous use for 2 weeks, "1: soft", "2: no change", "3: increased pain", among these After obtaining the answer from, the total number of panelists at each stage was obtained, and the ratio among the total panelists was calculated. Next, the ratio of panelists who answered "1: soft" was set to 100%, and this was replaced with 10 to obtain a numerical value, which was used as an index for evaluating pain caused by hyperesthesia.
The results are shown in Table 2. The larger the value, the stronger the tooth quality is due to the use of the dentifrice composition, which means that the pain due to hyperesthesia has been prevented or suppressed.

《Observation and evaluation of dentin tubules》
Approximately 1 cm square sections (about 500 μm thick) of bovine dentin were mirror-polished with sandpaper and sonicated for 10 minutes. Next, etching treatment was performed on a 1% citric acid aqueous solution for 20 seconds, and ultrasonic treatment was performed again for 10 minutes to completely remove the smear layer. Next, a toothpaste four-fold water dilution was prepared using the dentifrice composition obtained in Example 8, and brushing was performed once for 5 minutes under a load of 200 g. The state of the dentin tubules before and after using the dentifrice composition was observed using a SEM (VE-7800 manufactured by EYENCE, acceleration voltage: 2.0 kV) (the state of the outermost surface at a low acceleration voltage). Only observed). FIG. 1 shows a photograph of the opening of the dentin tubule before use, and FIG. 2 shows a photograph of the opening of the dentin tubule after use.
From FIG. 2, it was confirmed that the application of the dentifrice composition of the present invention can effectively block the opening of the dentin tubule shown in FIG.

Claims (8)

The following components (A) to (C):
(A) One or two kinds of fluorine ion supplying compounds selected from sodium fluoride and tin fluoride (B) Calcium glycerophosphate 0.35% by mass to 1.3% by mass (C) C12 to C18 A fatty acid divalent metal salt derived from a saturated fatty acid of 0.5 to 6% by mass, and a mass ratio of the content of the component (B) to the content of the component (C) ((B) / (C)) is 0.12 or more and 1.5 or less.   The oral composition according to claim 1, comprising one or more desensitizing agents (D) selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate.   The mass ratio ((A) / (B)) between the fluorine atom equivalent of the component (A) and the content of the component (B) is 0.12 or more and 0.8 or less. Oral composition.   The mass ratio ((A) / (C)) between the fluorine atom equivalent of the component (A) and the content of the component (C) is 0.01 or more and 0.3 or less. Item 2. The oral composition according to item 1.   The oral composition according to any one of claims 1 to 4, further comprising propylene glycol and a dentifrice composition.   The oral composition according to claim 5, further comprising an anionic surfactant in an amount of from 0.2% by mass to 3% by mass.   The oral composition according to claim 5, further comprising 2% by mass or more and 4% by mass or less of a binder.   The oral composition according to claim 6 or 7, wherein the content of the alkyl sulfate is 1% by mass or more and 50% by mass or less in the content of the anionic surfactant.