KR20160010667A - Toothpaste composition comprising sodium hydrogen carbonate and quillaia extract - Google Patents

Abstract

The present invention relates to a toothpaste composition comprising sodium hydrogen carbonate and an extract of Quillaia saponaria Molina. and, more specifically, to a toothpaste composition which does not need to comprise an abrasive and a synthetic surfactant harmful to a human body. The toothpaste composition in the present invention has excellent foamability, an excellent washing effect, is additionally effective to treatment of gum diseases and periodontal diseases, removal of mouth smell, mitigation of inflammation, and teeth whitening, maintains a user to feel refresh and clean for a long time compared with an existing toothpaste composition, and enables a user to feel less dry after tooth brushing compared with an existing toothpaste composition, when being used.

Description

[0001] TOOTHPASTE COMPOSITION COMPRISING SODIUM HYDROGEN CARBONATE AND QUILLAIA EXTRACT [0002]

The present invention relates to a dentifrice composition containing sodium hydrogencarbonate and quillaia extract. More particularly, the present invention relates to a dentifrice composition which does not require the use of a foaming agent such as an abrasive such as silicon dioxide and a synthetic surfactant, unlike a conventional dentifrice composition.

Oral is a very important organ for respiration and food intake, but it is also an institution that is constantly exposed to the outside environment through air and food. Therefore, unless cleanliness of the oral cavity is maintained through tooth brushing, plaque is generated in the periphery of the tooth and the gum.

A stigma is a very thin and transparent film consisting of bacteria, metabolites of bacteria or saliva of a living organism, which is a colorless bacterial film formed on the tooth surface.

When the plaque is formed, the bacteria inside it multiply exponentially using the sugar that is supplied through the food consumed by the host organism.

Bacteria in the dentition create toxins and free oxygen that breaks the gums, destroying the tissue surrounding the teeth. This causes irritation of the gums, redness of the gums, easy pouring and frequent bleeding. In addition, gaps between the gums and the teeth (gingival fissures) can open up a small pocket called a periodontal pouch. When the tooth builds up, the germs descend along the root surface to destroy the bone supporting the tooth, It is lost.

Dental calculus means that the unremoved plaque is deposited with saliva and calcium or phosphorus minerals in the gingival fissure. The calculus consists of about 75% of minerals and about 6 to 15% of organic matter and moisture.

Calcite itself may cause gum inflammation by stimulating the gum itself, but what is more problematic is that it becomes a hotbed of germs composed of bacteria. Therefore, once the tartar is formed, plaque is easily attached to the tartar, accelerating the progress of the gingival inflammation, causing the bad breath.

Host organisms use toothpaste to brush teeth to prevent the formation of these calculi and to effectively remove plaque.

However, general toothpastes contain a chemical abrasive such as silicon dioxide, precipitated calcium carbonate, tricalcium phosphate, or potassium nitrate in order to remove plaque or calculus attached to the teeth and to impart gloss to the teeth. Specifically, some commercially available toothpastes contain a strong abrasive such as silicon dioxide, depending on the type of toothpaste, and those containing weaker abrasives such as tricalcium phosphate or potassium nitrate have.

However, such an abrasive ingredient may cause cervical erosion, which may cause induction of dental hypersensitivity, and may cause irritation to the extent that it may damage the oral mucous membranes when brushing with excessive force . In particular, silicon dioxide, among other abrasive ingredients, is a first-level carcinogen that has been warned by the National Toxicology Task Force (NTP) and the International Carcinogenicity Research Institute (IARC) that long-term exposure to the human body poses a risk of carcinogenicity.

Therefore, there has been a demand for a dentifrice composition which does not contain an exciting abrasive ingredient or which can effectively remove plaque or calculus while containing a small amount of irritating abrasive ingredient.

As a part of the study, Korean Patent Laid-Open Publication No. 10-2008-0006109 proposes a foam dentifrice composition which gives a high-quality foam feeling in order to compensate for the disadvantages of the conventional toothpaste of the cream type or the jelly type containing the abrasive have.

Specifically, according to the above patent publication, the ratio of 0.8% by weight, based on the total weight of the composition, of foaming agent (anionic surfactant) such as sodium laurylsulfate and 0.3% by weight polyoxyethylene polyoxypropylene copolymer A pH adjusting agent such as 0.01 wt% citric acid, a sweetener such as 0.08 wt% sodium saccharin, 0.3 wt% of a flavoring agent, purified water and the like are mixed, It is possible to provide a foam dentifrice composition which can give a lighter and softer feeling when the toothbrush is brushed by lowering the specific gravity.

However, the above foam dentifrice composition is problematic because it contains a synthetic surfactant such as sodium lauryl sulfate as a foaming agent.

Because synthetic surfactants are substances that can easily react with other chemicals and have the potential to become carcinogens. In addition, according to a study published in October 2001 by a consumer environmental group, when petrochemical surfactants are used for a long period of time, they may cause disorders of body nerve function or decrease immunity, resulting in atopy, asthma or rhinitis.

Korean Patent Publication No. 10-2008-0006109

As described above, conventional dentifrice compositions contain a large amount of substances that cause damage to the mucosa or the like in the oral cavity, are carcinogenic substances, or cause environmental hormones. Typical examples thereof are abrasives such as silicon dioxide and foaming agents such as sodium lauryl sulfate. The dentifrice composition containing such a harmful substance may cause various side effects rather than effectively removing plaque or tartar which is an original role in use.

Disclosure of the Invention The present invention addresses the problem of the conventional dentifrice composition. More specifically, it is an object of the present invention to provide a dentifrice composition which does not contain an abrasive such as silicon dioxide and a synthetic surfactant or can sufficiently attain its original role even if it contains a small amount.

The present invention solves the above-described problems through the following means.

(1) A dentifrice composition containing sodium bicarbonate and quillaia extract.

(2) The dentifrice composition according to (1) above, further comprising at least one additive selected from the group consisting of wetting agents, thickeners, sweeteners, dental caries inhibitors and flavoring agents.

(3) In the above item (1) or (2), the humectant is at least one selected from the group consisting of D-sorbitol solution, glycerin and polyethylene glycol 1500, and the thickener is selected from the group consisting of hydrous silicic acid and sodium carboxymethylcellulose Wherein the sweetener is at least one selected from the group consisting of xylitol, sodium saccharin hydrate, chamomile extract, sage extract and propolis extract, the dental caries inhibitor is sodium fluoride, the flavoring agent is L-menthol and mint A flavoring agent and a flavoring agent.

(4) The dentifrice composition according to any one of (1) to (3) above, wherein the content of quillaia extract is 0.7 to 3.0% by weight based on the total weight of the composition.

(5) The dentifrice composition according to any one of (1) to (4), which does not contain a synthetic surfactant.

The present invention is advantageous in that sufficient air bubbles are generated even when the abrasive agent and the synthetic surfactant which are harmful to human body are not contained or contained in a small amount, and there is less inconvenience and irritation feeling when brushing teeth, and excellent washing power against plaque or tartar. Furthermore, the present inventors have surprisingly found that according to one embodiment of the present invention, the following effects are further expressed.

(1) Gum disease, periodontal disease, bad breath removal and inflammation improvement

(2) tooth whitening

(3) Compared to the conventional dentifrice composition, freshness and freshness are retained for a long time after brushing

(4) Less dryness after brushing than conventional dentifrice compositions

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a photograph of the foaming power of a dentifrice composition containing quillaia extract.
2 is a photograph of the foam force of a dentifrice composition containing an yukata extract.
3 is a photograph of the foam force of a dentifrice composition containing cocoa beet.
Fig. 4 compares the bubble counts of dental compositions containing quillaia extract, dentifrice compositions containing yucca extract, and dentifrice composition containing cocobetain.

As used herein, the term " wetting agent " refers to a component that is employed for the purpose of preventing toothpaste from contacting and solidifying in the air to give the toothpaste a moist and creamy appearance. Examples thereof include D-sorbitol solution, glycerin, polyethylene glycol, and the like, and can be appropriately selected by a person skilled in the art.

As used herein, the term " thickening agent " refers to a component that is employed for the purpose of preventing the separation of a solid component and a liquid component of a toothpaste. Examples thereof include sodium carboxymethylcellulose or hydrated silicic acid, and a person skilled in the art can appropriately select them.

As used herein, the term " sweetener " refers to a component that is employed for the purpose of imparting a certain aesthetics to a toothpaste and imparting a cooling sensation and the like. Examples thereof include xylitol, steviol glycoside, green tea extract, or sage extract, and can be appropriately selected by a person skilled in the art.

As used herein, " dental caries inhibitor " refers to a component employed for the purpose of preventing dental caries. Examples thereof include fluorine, etc., and can be appropriately selected by a person skilled in the art.

As used herein, " flavoring agent " refers to a component that is employed for the purpose of cleansing the mouth, giving a refreshing feeling, and suppressing a filthy smell in the mouth. Examples thereof include ginseng extract, propolis extract, cucumber oil, L-menthol, colimient flavor (HF-61399) or combination flavor (apple flavor, HF-30630).

[Toothpaste composition]

The dentifrice composition according to one embodiment of the present invention contains sodium hydrogencarbonate and quillaia extract.

In addition, the dentifrice composition according to one embodiment of the present invention further contains at least one additive selected from the group consisting of wetting agents, thickeners, sweeteners, dental caries inhibitors and flavoring agents.

[Sodium hydrogencarbonate]

In the conventional dentifrice composition, a small amount of sodium hydrogencarbonate has been utilized as a pH adjuster. In this connection, Legier et al. Have reported that sodium bicarbonate used as a pH buffer in dentifrice compositions can reduce the number of mutans streptococcus and Lactobacillus in saliva to exhibit anti-pharmacological effects 1995). In addition, Yankell et al. (1993) reported that a dentifrice composition containing sodium bicarbonate inhibited the formation of bacterial membranes on dentition and showed gentle drenching effects.

However, some publications disclose a dentifrice composition containing a large amount of sodium hydrogencarbonate. For example, U.S. Patent No. 4,891,211 discloses a dentifrice composition containing a large amount of sodium hydrogencarbonate . However, in general, sodium bicarbonate is known to have a disadvantage in that it can not effectively remove food residues, teeth or tooth surface contaminants that are trapped in the teeth due to a very low polishing force, and has a disadvantage that the saltiness due to a large amount of sodium bicarbonate causes the user to feel rejection have. Therefore, simply containing a large amount of sodium hydrogencarbonate is not preferable as a dentifrice composition.

The dentifrice composition according to one embodiment of the present invention contains sodium hydrogencarbonate. In particular, the dentifrice composition according to one embodiment of the present invention may contain not less than 30% by weight, preferably not less than 40% by weight, more preferably not less than 60% by weight, based on the total weight of the composition, Sodium bicarbonate, and the upper limit of the content thereof can be suitably selected by a person skilled in the art within a range that does not impair the original function of the dentifrice composition.

Thus, although one embodiment of the present invention contains a large amount of sodium hydrogencarbonate, a generally disadvantageous point that can be predicted when the dentifrice composition is used as a dentifrice composition is not exhibited, and rather an unexpected desirable effect is exhibited.

[Quillaia extract]

Quillaia extract is a substance contained in the bark of rose and evergreen tree called Quillaia saponaria MOLINA distributed in Chile, Bolivia or Peru region of South America. It is obtained by extracting and extracting bark of rose quillaia from water. These quillaia extracts are currently on the market.

One embodiment of the present invention is characterized by combining sodium bicarbonate and quillaia extract. In particular, the dentifrice composition according to one embodiment of the present invention may contain 0.1% by weight or more, preferably 0.5% by weight or more, more preferably 0.5% by weight or more, based on the total weight of the composition, of quillaia extract for the purpose of remarkably expressing the desired effect of the present invention Is contained in an amount of 1% by weight or more and 10% by weight or less, preferably 5% by weight or less, more preferably 3% by weight or less.

[additive]

The dentifrice composition according to one embodiment of the present invention further contains at least one additive selected from the group consisting of wetting agents, thickeners, sweeteners, dental caries inhibitors and flavoring agents. Particularly, in the remarkable manifestation of the desired effect of the present invention, the humectant is at least one selected from the group consisting of D-sorbitol solution, glycerin and polyethylene glycol 1500, and the thickener is selected from the group consisting of hydrous silicic acid and carboxymethylcellulose sodium And the sweetener is one or more selected from the group consisting of xylitol, sodium saccharin hydrate, chamomile extract, sage extract and propolis extract, the dental caries inhibitor is sodium fluoride, the flavoring agent is L-menthol and mint flavor And a flavoring agent.

In addition, the dentifrice composition according to one embodiment of the present invention may contain other additives that can be incorporated into the dentifrice composition.

Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.

Example 1 - Preparation of dentifrice composition containing quillaia extract

The ingredients listed in Table 1 below were added to the mixing apparatus and stirred for 20 minutes to obtain the final product.

ingredient Content (g) Sodium hydrogencarbonate 65 Sodium fluoride 0.22 D-sorbitol solution 15 glycerin One Polyethylene glycol 1500 2 Function silicate 8 Carboxymethylcellulose sodium 0.8 Xylitol 0.2 Sodium saccharin hydrate 0.3 Chamomile extract 0.01 Sageex 0.001 Propolis extract 0.01 L-menthol 0.2 Mint flavoring agent 0.6 Quillaia extract 2 Purified water 4.659

The Wuquilaya extract used was Quillaia extract prepared from National Starch (U.S.A).

Comparative Example 1 - Preparation of dentifrice composition containing yucca extract

The materials shown in the following Table 2 were added to the mixing apparatus and stirred for 20 minutes to obtain the final product.

ingredient Content (g) Sodium hydrogencarbonate 65 Sodium fluoride 0.22 D-sorbitol solution 15 glycerin One Polyethylene glycol 1500 2 Function silicate 3 Carboxymethylcellulose sodium 0.8 Xylitol 0.2 Sodium saccharin hydrate 0.3 Chamomile extract 0.01 Sageex 0.001 Propolis extract 0.01 L-menthol 0.2 Mint flavoring agent 0.6 Yucca extract 2 Purified water 4.659

Comparative Example 2 - Preparation of dentifrice composition containing cocoa betaine

The materials shown in the following Table 3 were added to the mixing apparatus and stirred for 20 minutes to obtain the final product.

ingredient Content (g) Sodium hydrogencarbonate 65 Sodium fluoride 0.22 D-sorbitol solution 15 glycerin One Polyethylene glycol 1500 2 Function silicate 3 Carboxymethylcellulose sodium 0.8 Xylitol 0.2 Sodium saccharin hydrate 0.3 Chamomile extract 0.01 Sageex 0.001 Propolis extract 0.01 L-menthol 0.2 Mint flavoring agent 0.6 Coco Betaine 2 Purified water 4.659

Comparative Example 3 - Preparation of dentifrice composition containing synthetic surfactant

The ingredients shown in Table 4 below were added to the mixing apparatus and stirred for 20 minutes to obtain the final product.

ingredient Content (g) Silicon dioxide 8 Tocopherol acetate 0.182 D-sorbitol solution 64 Polyethylene glycol 1500 One Function silicate 9 Carboxymethylcellulose sodium 0.9 Sodium saccharin hydrate 0.135 Sodium lauryl sulfate 2.4 L-menthol 0.2 Mint flavoring agent One Purified water 13.183

Experimental Example 1 - Bubble strength test

The bubble strength test was carried out as follows.

100 ml of a 1% solution was prepared in a 200 ml beaker per sample and agitated at 500 rpm for 60 seconds with an agitate mixer (AGI). Thereafter, the solution was poured into a 100-ml measuring cylinder, and then ascertained how much was increased by 100 ml.

The results are shown in FIG. 1 to FIG. 4, and the amount of expanded bubbles was measured by specific numerical values, as shown in Table 5 below.

Sample Increased bubble volume Example 1 65 ml Comparative Example 1 3 ml Comparative Example 2 20 ml

Yucca extract and cocoa betaine which are used as natural foam in beverages or shampoos were very disappointing when used as a dentifrice composition and were not suitable for brushing. However, although the specific cause of the quillaia extract is not known, when it is combined with sodium bicarbonate or the like and used as a dentifrice composition, its foaming power is excellent even if no additional synthetic surfactant or foaming agent is added. That is, it is confirmed that natural bubbles used in beverages or shampoos can not be preferably used in dentifrice compositions in which the specific ingredients are different from each other. This is presumed to be the result of the undiscovered interaction between the unknown ingredient and the dentifrice composition containing sodium hydrogencarbonate, each of which contains different components for each of the natural extracts.

Experiment 2 - Test of feeling

Fifty subjects with periodontal disease, gingival bleeding, irritable bowel syndrome, and gingival disease were selected and divided into two groups of randomly selected 25 subjects. Fifty subjects divided into two groups were allowed to use the toothpaste prepared in Example 1 and Comparative Example 3 three times a day for four weeks. During this period, the subjects were prohibited from taking oral antibiotics and oral care which could affect the experiment.

Then, the gum disease treatment effect, the bad breath removing effect and the feeling sensory evaluation were performed by the following methods, and the results are shown in Table 6.

(1) Measuring gum disease treatment effect

After using the toothpaste prepared in Example 1 and Comparative Example 3 for 4 weeks, the subjects of each experimental group were evaluated on the basis of the 5-point scale for the treatment of gum disease such as periodontitis, gum bleeding, And the average value thereof was measured.

Evaluation criteria: 1 point: very unsatisfied, 2 points: unsatisfied, 3 points: average, 4 points: satisfaction, 5 points: very satisfied

(2) Measurement of bad breath removal effect

The halitosis degree of the subjects of each experimental group was measured before and after using the toothpaste prepared in Examples 1 and 3 (before the experiment and before the rinse) and after 4 weeks (after the rinse and after the rinse) , And the average value was compared.

(3) Sensory evaluation

The subjects of each experimental group were evaluated for their sensation of irritation during toothbrushing, freshness, freshness, and dryness after toothpaste daily during the use of the toothpaste prepared in Example 1 and Comparative Example 3 for 4 weeks, and then the average value thereof was measured. Herein, the stimulation means the stimulation to the mucous membranes in the oral cavity, including the gums and teeth, and the freshness means that the mouthful refreshing feeling lasts for a certain period of time after the mouth brushing. It is said that the feeling of cleanliness that the dentition or the calculus including the food is cleansed neatly for a certain period of time, and the dryness means the feeling that the mouth becomes dry after brushing.

Assessment criteria for stimuli: 1 point: very irritating, 2 points: slightly irritating, 3 points: normal, 4 points: slightly irritating, 5 points: not at all irritating

Refreshing Evaluation Criteria: 1 point: not refreshing at all, 2 points: slightly refreshing, 3 points: normal, 4 points: slightly refreshing, 5 points: very refreshing

2 points: not good luck, 3 points: normal, 4 points: somewhat lax, 5 points: very lucky

Dryness Evaluation Criteria: 1 point: very dry, 2 points: slightly dry, 3 points: normal, 4 points: slightly dry, 5 points: not at all dry

division Item Example 1 Comparative Example 3 Gum disease Periodontitis 3.5 3.7 Bleeding gums 4.0 4.0 Igarashim 3.1 3.5 Bad breath Just before the experiment 210.4 230.3 After 4 weeks 100 125.2 Feeling Irritability 4.9 1.5 Refreshing 4.0 3.7 Recuperation 3.2 3.7 Dry 4.5 1.2

As a result, in both Example 1 and Comparative Example 3, the treatment satisfaction for gum disease was more than usual. Also, in Example 1 and Comparative Example 3, halitosis reduction rate, freshness and freshness were satisfactory.

However, Comparative Example 3 containing an abrasive such as silicon dioxide and a synthetic surfactant is irritating to the feeling of use, and tends to become dry after the mouthwash after the mouthwashing, while the sodium bicarbonate and quillaia extract It was found that Example 1 was not irritating at all in feeling and had no tendency to dry the mouth even after gargling.

That is, when the sodium bicarbonate and the quillaia extract are mixed in the dentifrice composition, the detergent for the toothpaste, which is an original function that the toothpaste has to have, which is not contained in the synthetic surfactant, and other dirt including the tartar is excellent, It has been found for the first time that there is a prophylactic and therapeutic effect of gum disease, less irritation and, above all, surprisingly less dryness than toothpastes containing conventional synthetic surfactants.

Claims (5)

Sodium hydrogencarbonate, and quillaia extract. The dentifrice composition according to claim 1, further comprising at least one additive selected from the group consisting of wetting agents, thickeners, sweeteners, dental caries inhibitors and flavoring agents. The method of claim 2, wherein the humectant is at least one selected from the group consisting of D-sorbitol solution, glycerin, and polyethylene glycol 1500, the thickening agent is at least one selected from the group consisting of hydrous silicic acid and carboxymethylcellulose sodium, Xylitol, saccharin sodium hydrate, chamomile extract, sage extract and propolis extract, the dental caries inhibitor is sodium fluoride, and the flavoring agent is selected from the group consisting of L-menthol and mint flavoring agent Of the toothpaste composition. The dentifrice composition according to claim 1, wherein the content of quillaia extract is 0.7 to 3.0% by weight based on the total weight of the composition. The dentifrice composition according to any one of claims 1 to 4, which is free of a synthetic surfactant.

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