JP7310357B2 - oral composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to an oral composition that provides a high feeling of cleansing with a unique sensation of popping bubbles in the oral cavity.

In oral compositions such as dentifrices, if the oral cavity is cleansed during and after use and gives a satisfactory feeling of refreshment, it promotes continuous use and prevents daily periodontal disease, bad breath, etc. Alternatively, it can also lead to suppression, and an improvement in effect can be expected. From such a point of view, it is desired to develop an oral composition that is highly palatable by further improving the effect feeling such as cleansing feeling so that the user of the oral composition will be more satisfied.

Fragrance ingredients used in oral compositions contain menthol, cooling agents, and the like to provide a refreshing feeling during and after use, but when accompanied by bitterness and irritation, or insufficient refreshing feeling. Sometimes.
In addition, by blending spice components such as spiranthol and capsicum as flavoring components, by imparting taste stimuli such as astringency, spiciness, and bitterness, the refreshing feeling is reinforced. Although it is known that various active ingredients that give medicinal effects can produce a feeling of effectiveness, some of these fragrance ingredients have strong irritation and bitterness, and are limited to medicinal products such as periodontal disease prevention. There were many.

Patent Document 1 (Patent No. 5251350) discloses a combination of a cooling sensation imparting agent such as menthol and a specific cooling sensation imparting agent and sodium chloride or the like to improve cooling sensation and suppress bitterness and unpleasant taste. It is suggested that adding spiranthol, red pepper, etc. can further soften the bitterness and unpleasant taste. In Patent Document 2 (Patent No. 5748626), when the composition for oral cavity is blended with a bactericide together with a Japanese pepper extract and guaiacol at a specific ratio, the medicinal effect, the feeling of effectiveness, and the disgusting masking property are improved, and the palatability is also good. is proposed to be Patent Document 3 (Japanese Patent No. 5897843) discloses that when an oral composition containing a specific spice extract, especially a chewing gum, is mixed with a mint flavor, menthol and a cooling enhancer in specific amounts, respectively, the taste and freshness of mint can be obtained. proposes to persist. Patent Document 4 (Japanese Patent Application Laid-Open No. 2015-43769) discloses that oral compositions containing hydroxy-α-sanshool and/or 2-phenylbutanol, preferably chewing gums and candies, are excellent in saliva secretion effect, moistening effect, etc. is proposing.

Japanese Patent No. 5251350 Japanese Patent No. 5748626 Japanese Patent No. 5897843 JP 2015-43769 A

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral composition that provides a highly cleansing feeling with a unique sensation of popping bubbles in the oral cavity.

As a result of intensive studies to achieve the above object, the present inventors have found that 1 selected from (A) Sichuan pepper extract, (B) cineole, (C) (C1) citral and (C2) limonene It has been found that when combined with more than seeds and mixed into an oral composition, it is possible to impart a high cleaning feeling due to the unique sensation of popping bubbles in the oral cavity, and also that the unpleasant taste is suppressed and the taste is good. , which led to the present invention.

More specifically, in the present invention, the fragrance composition in which the components (A), (B) and (C) are combined is such that foam pops in the oral cavity when the oral composition is put in the mouth during use. For example, instead of foaming caused by general surfactants, a unique feeling (foaming feeling) like so-called carbonic acid foaming is felt, and the feeling lasts even after rinsing the mouth after use. Due to the foaming sensation, it was possible to give an effect feeling that the inside of the oral cavity was washed. In addition, the components (A), (B) and (C) each have an irritating and bitter taste, etc., but by combining the components (A), (B) and (C), it is possible to reduce the unpleasant taste caused by each flavoring component. It was also possible to suppress such odors without making them feel sarcasm, and to give a good taste without sarcasm.
In the present invention, when (D) a cooling agent is further added, the feeling of cleansing after use could be further improved.
The composition for oral cavity of the present invention provides a high feeling of cleansing due to the above-mentioned unique foaming sensation, which is different from the refreshing feeling and effect caused by conventional cooling sensation-imparting ingredients such as menthol, and has a good taste, so it is highly palatable. I can expect it.
As is clear from the results of the comparative examples described later, if any of the components (A), (B) and (C) related to the present invention is not included, the feeling of cleaning (foaming feeling) during and after use ) was weak, and even though it contained menthol, which gives a general cooling sensation as an oral fragrance, and ethanol, the feeling of cleansing was weak and inferior as described above (Comparative Examples 1 to 9). In contrast, as shown in the Examples, oral compositions containing components (A), (B) and (C) of the present invention (Examples 1 to 44) were washed during and after use. The feeling was excellent, and the lack of sarcasm was also excellent.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) Sichuan pepper extract,
(B) Cineole and an oral composition containing one or more selected from (C) (C1) citral and (C2) limonene.
[2]
The oral composition according to [1], wherein (B)/(A) is 0.2 to 500 as a mass ratio.
[3]
When containing component (C1) as component (C), (C1) / (A) is 0.01 to 50 as a mass ratio, and when containing component (C2), (C2) / (A) is The oral composition according to [1] or [2], which has a mass ratio of 1 to 3,000.
[4]
The oral cavity composition according to any one of [1] to [3], wherein the content of component (A) is 0.001 to 0.1% by mass as a pure content.
[5]
The oral composition according to any one of [1] to [4], wherein the content of component (B) is 0.01 to 2% by mass.
[6]
When it contains component (C1), its content is 0.001 to 0.2% by mass, and when it contains component (C2), its content is 0.05 to 10% by mass [1] The composition for oral cavity according to any one of [5].
[7]
The oral cavity composition according to any one of [1] to [6], further comprising (D) a cooling agent in an amount of 0.001 to 2% by mass.
[8]
(D) the cooling agent is N-ethyl-p-menthane-3-carboxamide, N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide and N-(2-(2-pyridinyl) The oral composition according to [7], which is one or more p-menthane-3-carboxamides selected from ethyl)-2-isopropyl-5-methylcyclohexanecarboxamides.
[9]
The oral composition according to any one of [1] to [8], further comprising (E) 0.1 to 5% by mass of a surfactant.
[10]
The oral composition according to any one of [1] to [9], which is a dentifrice, mouthwash or mouth spray.

ADVANTAGE OF THE INVENTION According to this invention, the composition for oral cavity which gives a high feeling of washing|cleaning by a unique feeling like bursting foam|bubbles in an oral cavity, and also has a pleasant taste with suppressed unpleasant taste can be provided. The oral composition provides a satisfactory feeling of effectiveness through the actual feeling of cleaning, and can be expected to capture the preferences of users of oral products for a wide variety of purposes. is suitable for

The present invention will be described in further detail below. The oral composition of the present invention contains one or more selected from (A) situan pepper extract, (B) cineole, and (C) (C1) citral and (C2) limonene. In the present invention, the combination of the perfume ingredients (A), (B) and (C) acts as a cleansing agent in the oral composition.
In the present invention, the “feeling of cleansing” is the feeling that the inside of the oral cavity is cleansed by the feeling of bursting bubbles in the oral cavity (feeling of foaming) when put in the mouth (the same shall apply hereinafter).

(A) Sichuan pepper, which is the raw material for the Sichuan pepper extract, is generally known as Sichuan pepper, and is a deciduous shrub of the genus Zanthoxylum of the Rutaceae family in China. Dried peels of Sichuan pepper can be used. As the Sichuan pepper extract, extracts such as essential oils and extracts obtained by known methods using the above raw materials can be used. For example, commercially available essential oils obtained by steam distillation, and supercritical extracts using carbon dioxide is mentioned. Among them, a supercritical extract using carbon dioxide is preferable in terms of clean feeling.
As the component (A), for example, Sichuan Pepper Absolute CO2 Extract (trade name: SICHHUAN PEPPER ABSOLUTE CO2 EXTRACT, 100% pure product) manufactured by Shalabo Co., Ltd. can be used.

In the present invention, even if it belongs to the genus Zanthoxylum of the Rutaceae family, the extract of a plant different from Sichuan pepper, for example, the extract of Zanthoxylum piperitum, which is common in Japan, is not suitable. Even if the extract was blended, if the component (A) was not blended, the feeling of cleansing was low and the effects were inferior.

(A) The amount of the Sichuan pepper extract to be blended is preferably 0.001 to 0.1% (% by mass, hereinafter the same), more preferably 0.01 to 0.05%, based on the total composition. When the blending amount is 0.001% or more, a sufficient feeling of cleansing can be obtained. If it is 0.1% or less, the offensive taste (irritating taste) of the situan pepper extract itself can be sufficiently suppressed. The above compounding amount is the pure amount of the Sichuan pepper extract (the same shall apply hereinafter).

(B) Cineol can be a commercially available cineole, for example, a product manufactured by Eikodo Honten Co., Ltd., or the like. As the component (B), cineol-containing essential oils such as eucalyptus oil and rosemary oil can also be used.

The content of (B) cineole is preferably 0.01 to 2%, more preferably 0.1 to 1% of the total composition. When the blending amount is 0.01% or more, a sufficient feeling of cleansing can be obtained. If it is 2% or less, the unpleasant taste (bitterness) of cineole itself can be sufficiently suppressed.

The component (C) is selected from (C1) citral and (C2) limonene, and may be the component (C1) or the component (C2), or a combination of the components (C1) and (C2).
As component (C), commercially available citral and/or limonene, such as products manufactured by Hasegawa International Corporation and Takasago International Corporation, can be used.
As component (C), essential oils containing citral and/or limonene, such as lemon oil, orange oil and grapefruit oil, can also be used.

(C) The compounding quantity of the component is preferably within the following range.
When (C1) citral is blended, the blending amount is preferably 0.001 to 0.2%, more preferably 0.005 to 0.1% of the total composition. When the blending amount is 0.001% or more, a sufficient feeling of cleansing can be obtained. If it is 0.2% or less, the unpleasant taste (oiliness) of citral itself can be sufficiently suppressed.
(C2) When limonene is blended, its blending amount is preferably 0.05 to 10%, more preferably 0.2 to 5% of the total composition. When the blending amount is 0.05% or more, a sufficient feeling of cleansing can be obtained. When it is 10% or less, the unpleasant taste (oiliness) of limonene itself can be sufficiently suppressed. If the blending amount exceeds 10%, liquid separation or the like may occur and the appearance stability may deteriorate.
The preferred total amount of component (C) is within the range obtained by adding up the above compounding amounts of component (C1) and/or component (C2).

In the present invention, (B)/(A), which indicates the quantitative ratio of component (A) to component (B), is preferably from 0.2 to 500, more preferably from 3 to 100 as a mass ratio. Within this range, the feeling of washing is particularly excellent, the nasty taste is sufficiently suppressed, and the feeling of use is also excellent. If the (B)/(A) mass ratio is less than 0.2 or more than 500, the feeling of cleansing may be poor.
Further, the quantitative ratio of the component (A) and the component (C) is 0.01 to 50 as a mass ratio of (C1)/(A), especially when (C1) citral is blended as the component (C). 0.1 to 5 is preferable, and when (C2) limonene is blended, (C2)/(A) is 1 to 3,000 as a mass ratio, particularly 1 to 1,000, and particularly preferably 5 to 200. . Within the above ranges, the feeling of cleansing can be improved, a significantly higher feeling of cleansing can be imparted, and unpleasant taste can be further suppressed. If the mass ratio of (C1)/(A) exceeds 50, a sufficient feeling of cleansing may not be obtained, and the effect of suppressing unpleasant taste may not be obtained sufficiently. Also, when the amount of component (C2) is too large and the mass ratio of (C2)/(A) exceeds 3,000, liquid separation may occur.

In the present invention, it is preferable to further add (D) a cooling agent. When (D) a cooling agent is added, the feeling of cleansing after use is improved, and the lasting feeling of cleansing is particularly excellent.
Menthol derivatives, p-menthane-3-carboxamides and the like can be used as cooling agents. Specific examples of menthol derivatives include menthyl lactate, monomenthyl succinate, monomenthyl glutarate, and 3-L-menthoxypropane-1,2-diol. N-ethyl-p-menthane-3-carboxamide, N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide, N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5 -methylcyclohexane carboxamide and the like. Particularly preferred are p-menthane-3-carboxamides. These may be used singly or in combination of two or more.

A commercial item can be used for the cooling agent. For example, N-ethyl-p-menthane-3-carboxamide (WS-3 manufactured by Givaudan Japan Co., Ltd.), N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide (Givaudan Japan Co., Ltd. ) manufactured by Evercool G-180) and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide (Givaudan Japan Co., Ltd. Evercool G-190).

The content of (D) cooling agent is preferably 0.001 to 2%, more preferably 0.01 to 1% of the total composition. When the amount is 0.001% or more, the feeling of cleansing is sufficiently maintained even after use, and when the amount is 2% or less, the unpleasant taste (bitterness) is sufficiently suppressed and the flavor expression is good.

The oral composition of the present invention can further contain (E) a surfactant.
Surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants. Specifically, the following can be used singly or in combination of two or more.

Anionic surfactant:
Alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate; Acyl taurine such as lauroyl methyl taurine or salts thereof; Sodium lauryl sulfoacetate; α-olefin sulfonates; Acyl amino acid salt nonionic surfactant of:
Polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil; Polyoxyethylene higher alcohol ethers such as polyoxyethylene lauryl ether and polyoxyethylene cetyl ether; Sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan Fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester cationic surfactant:
Distearylmethylammonium Chloride, Stearyldimethylbenzylammonium Chloride Zwitterionic Surfactants:
Betaines such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and fatty acid amidopropyl betaine

As the anionic surfactant, acyl taurine or a salt thereof, especially; lauroyl methyl taurine salt, is preferred.
Polyoxyethylene hydrogenated castor oil is particularly preferred as the nonionic surfactant. The average number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is preferably 3-200, more preferably 20-100.
Among these, anionic surfactants and nonionic surfactants are preferred, and in particular, nonionic surfactants, especially polyoxyethylene hydrogenated castor oil, are expected from the point that foaming of surfactants can be expected to reinforce the feeling of cleaning. is more preferred.
(E) The content of the surfactant is preferably 0.1 to 5%, more preferably 0.5 to 3% of the total composition.

The oral composition of the present invention can be prepared in the form of a paste, a liquid, or the like, and can be prepared into dentifrices such as toothpaste, liquid dentifrice, wet dentifrice, mouthwash, and mouth spray. It is suitable as a mouthwash, especially a dentifrice.
Further, if necessary, in addition to the above components, other known additives according to the dosage form can be blended within a range that does not impair the effects of the present invention. For example, abrasives, thickeners, binders, sweeteners, preservatives, various active ingredients, colorants, pH adjusters, fragrances, etc. can be blended, and these ingredients are mixed with water to produce. be able to.
In the present invention, ethanol may be blended or may not be blended, and the content of ethanol may be 0 to 50% or 3 to 40% of the total composition. In the oral cavity composition, a trace amount of ethanol may be contained in the perfume or the like blended in the composition, and ethanol other than such ethanol may not be blended. In this case, the ethanol content is 1%. It may be 0.5% or less, particularly 0.3% or less.

Examples of abrasives include silica-based abrasives such as anhydrous silicic acid, silica gel, aluminosilicate, zirconosilicate, and crystalline zirconium silicate; dicalcium phosphate anhydrous or dihydrate; Calcium phosphate polishing agents such as calcium octaphosphate and calcium pyrophosphate, alumina, titanium dioxide, polymethyl methacrylate, insoluble calcium metaphosphate, calcium carbonate, magnesium carbonate, magnesium tertiary phosphate, zeolite, hydroxyapatite, fluoroapatite, synthetic resin polishing agents and the like. Abrasives may not be blended (0% blended amount), but when blended, the blended amount is preferably 2 to 50%, particularly 10 to 40%, of the total composition.

Examples of thickening agents include sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, mannitol, reduced starch saccharification products, glycerin, propylene glycol, and an average molecular weight (average molecular weight according to the Standards for Quasi-drug Ingredients 2006) of 200 to 6. ,000 polyethylene glycol, polyhydric alcohol such as ethylene glycol.
The blending amount of the thickening agent is usually 5 to 50% of the total composition.

Binders include organic binders such as sodium polyacrylate, xanthan gum, carrageenan, sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carbopol, guar gum, gelatin, crystalline cellulose, polyvinyl alcohol, and polyvinylpyrrolidone. and inorganic binders such as gelling silica, gelling aluminum silica, montmorillonite, kaolin, and bentonite. The blending amount of the organic binder is preferably 0.01 to 5% of the total composition, and the blending amount of the inorganic binder is preferably 0.1 to 10% of the total composition.

Sweetening agents include saccharin sodium, aspartame, stevioside, stevia extract, neohesperidyl dihydrochalcone, perillartine and the like.
Examples of antiseptics include paraoxybenzoic acid esters such as butylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.

As active ingredients, known ingredients that are usually blended in oral compositions, such as fluorides, bactericides, anti-inflammatory agents, enzymes, plant extracts, anti-calculus agents, anti-plaque agents, etc., can be used according to the present invention. An effective amount can be added as long as the effect is not impaired. Specifically, fluorides such as sodium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, sodium salt of orthophosphate, tranexamic acid, epsilon aminocaproic acid, tocopherol acetate, α-bisabolol , dihydrocholesterol, chlorhexidine salts, azulene, glycyrrhetin, glycyrrhetinic acid, glycyrrhizic acid or salts thereof, copper compounds such as sodium copper chlorophyllin, chlorophyll, copper gluconate, chelating phosphate compounds such as glycerophosphate, hydroxamic acid or derivatives thereof , sodium tripolyphosphate, methoxyethylene, epidihydrocholesterin, isopropylmethylphenol, benzethonium chloride, cetylpyridinium chloride, allantoin chlorohydroxyaluminum, ascorbic acid or its salts, ascorbic acid phosphate or its salts, lysozyme chloride, trichlorocarbani Lid, zinc citrate, and Phellodendron extract.

As a coloring agent, Blue No. 1, Yellow No. 4, Green No. 3, etc. can be blended in a usual amount.
Examples of the pH adjuster include organic acids such as citric acid, lactic acid and malic acid or salts thereof, phosphoric acid or salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide and potassium hydroxide.

Examples of fragrances include anise oil, wintergreen oil, thyme oil, sage oil, cardamom oil, coriander oil, lavender oil, chamomile oil, caraway oil, marjoram oil, lemongrass oil, origanum oil, pine needle oil, neroli. Natural fragrances such as oil, rose oil, jasmine oil, iris concrete, absolute rose, orange flower, etc., and processing of these natural fragrances (pre-reservoir cut, post-reservoir cut, fractionation, liquid-liquid extraction, essence formation, powder Perfume, etc.), menthol, carvone, anethole, methyl salicylate, thymol, linalool, linalyl acetate, menthone, menthyl acetate, pinene, octylaldehyde, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate , allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenylglycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, trimethylpyrazine, ethyl lactate, methyl lactate, Oral compositions such as individual flavors such as ethyl thioacetate, and compound flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, mixed fruit flavor, and tropical fruit flavor. can be used. The amount of these perfume materials to be blended is not particularly limited, but it is preferable to use 0.000001 to 1% in the composition. Further, it is preferable to use 0.1 to 2% of the perfume for perfuming using the above perfume material in the composition.
In addition, in the present invention, when menthol is blended, its content is preferably 0.1 to 5%, particularly 0.3 to 2%, of the entire composition, or even if menthol is not blended (content of 0% )good.

EXAMPLES Hereinafter, the present invention will be specifically described by showing Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
According to the composition shown in Table 1, dentifrice compositions (toothpaste) shown in Tables 2 to 7 were prepared by a conventional method. The resulting dentifrice composition was evaluated by the method described below, and the results are also shown in the table.
In addition, the numerical value which shows the compounding quantity of (A) component in a table|surface is a pure amount.

(*) The composition of the perfume is as follows.
Anethole 10
Menthol 50
Ethanol 40
Total 100%

The raw materials used for the preparation of the dentifrice composition are shown below.
(A) Sichuan pepper extract (trade name; SICHUAN PEPPER
ABSOLUTE CO2 EXTRACT, manufactured by Shalabo Co., Ltd., AI; 100%)
(B) Cineole (manufactured by Eikodo Co., Ltd.)
(C) (C1) citral (manufactured by Hasegawa Perfumery Co., Ltd. (C) (C2) limonene (manufactured by Takasago International Corporation)
(D) N-ethyl-p-menthane-3-carboxamide (trade name; WS-3, manufactured by Givaudan Japan Co., Ltd.)
(D) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide (trade name; Evercool G-180, manufactured by Givaudan Japan Co., Ltd.)
In addition, polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, sodium lauroyl methyl taurate, and components other than the above are all Ingredient standard) standard product was used, and purified water was used as cosmetic raw material (cosmetic raw material standard) standard product.

Evaluation method It was evaluated by 10 subjects. Take 1 g of the dentifrice composition on a toothbrush (Dentor Systema Lion Toothbrush, Regular, manufactured by Lion Co., Ltd.), and brush for 3 minutes. A sensory test was performed for absolute evaluation of the lackiness, using the following rating criteria.
The average values of 10 people were obtained and evaluated according to the following evaluation criteria.

Here, the feeling of cleansing during use means the actual feeling that the inside of the oral cavity is cleansed by the sensation of popping bubbles in the oral cavity (feeling of foaming) when put in the mouth.
Moreover, the feeling of cleansing after use refers to the feeling that the inside of the oral cavity is cleansed by the above sensation (feeling of bubbling) even after rinsing the mouth.

(i) Feeling of cleansing during use Rating criteria 4 points: Very clean feeling in the oral cavity 3 points: Clean feeling in the oral cavity 2 points: Some clean feeling in the oral cavity 1 point: Cleansing in the oral cavity Evaluation criteria Average score of feeling of cleaning during use ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and 3.0 points Less than ×: 1.0 points or more and less than 2.0 points

(ii) Feeling of cleansing after use Rating criteria 4 points: Very clean feeling in the oral cavity 3 points: Clean feeling in the oral cavity 2 points: Some clean feeling in the oral cavity 1 point: Cleansing in the oral cavity Evaluation criteria Average score of feeling of cleaning after use ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and 3.0 points Less than ×: 1.0 points or more and less than 2.0 points

(iii) Absence of sarcasm Rating criteria 4 points: Almost no sarcasm 3 points: A little sarcasm, but no problem 2 points: Smells 1 point: Very sarcasm Evaluation criteria Average score for no sarcasm ◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more and less than 2.0 points

As can be seen from the results in Tables 2 to 6, the dentifrice compositions (Examples) of the present invention had excellent clean feeling during and after use, and also had a good taste with suppressed unpleasant taste. On the other hand, as can be seen from the results in Table 7, the dentifrice composition lacking any of the components (A), (B) and (C) (Comparative Example) was cleaned during and after use. I didn't feel well.

A formulation example is shown below. The oral formulations of the formulation examples were prepared by a conventional method using the same raw materials as above, and each was used by a conventional method and evaluated in the same manner as above. , The sarcasm was suppressed and the taste was also good.

[Prescription Example 1] (Mouthwash)
(A) Sichuan pepper extract 0.01
(B) cineol 0.1
(C) (C1) citral 0.01
(E) Polyoxyethylene (60) hydrogenated castor oil 0.3
Ethanol 5
Propylene glycol 2
Glycerin 2
xylitol 3
Sodium citrate 0.25
Perfume 0.1
Remainder of purified water
Total 100.0%
(B)/(A)=10, (C1)/(A)=1

[Prescription Example 2] (Mouthwash)
(A) Sichuan pepper extract 0.005
(B) Cineole 0.02
(C) (C2) limonene 0.05
(E) Polyoxyethylene (60) hydrogenated castor oil 0.4
(E) Polyoxyethylene (15) cetyl ether 0.2
(E) Sodium lauroyl methyl taurate 0.2
Sodium benzoate 0.3
Propylene glycol 3
Glycerin 2
xylitol 4
Sodium citrate 0.25
Methyl paraoxybenzoate 0.05
Perfume 0.05
Remainder of purified water
Total 100.0%
(B)/(A)=4, (C2)/(A)=10

[Prescription Example 3] (mouth spray)
(A) Sichuan pepper extract 0.005
(B) Cineole 0.05
(C) (C1) citral 0.01
(C) (C2) limonene 0.25
(E) Polyoxyethylene (60) hydrogenated castor oil 3
Ethanol 35
Glycerin 10
xylitol 2
Saccharin sodium 0.3
Sodium citrate 0.15
Perfume 0.5
Remainder of purified water
Total 100.0%
(B)/(A)=10, (C1)/(A)=2, (C2)/(A)=50

[Prescription Example 4] (Toothpaste)
(A) Sichuan pepper extract 0.03
(B) Cineol 0.5
(C) (C1) citral 0.01
(C) (C2) limonene 0.05
(D) N-ethyl-p-menthane-3-carboxamide 0.05
(E) polyoxyethylene (20) hydrogenated castor oil 1.5
(E) sodium tetradecene sulfonate 0.3
(E) Coconut fatty acid amidopropyl betaine 0.5
(E) sodium lauroyl sarcosinate 0.1
Sorbitol 35
Propylene glycol 4
Polyethylene glycol 4000 0.4
abrasive silica 15
Thickening silica 3
Xanthan gum 0.8
Carrageenan 0.8
Sodium polyacrylate 0.5
Methyl paraoxybenzoate 0.18
Titanium oxide 0.5
Citric acid 0.1
sodium hydroxide 0.24
Sodium fluoride 0.3
Saccharin sodium 0.18
Perfume 0.5
Remainder of purified water
Total 100.0%

[Prescription Example 5] (Toothpaste)
(A) Sichuan pepper extract 0.03
(B) Cineole 0.5
(C) (C1) citral 0.01
(C) (C2) limonene 0.05
(D) N-ethyl-p-menthane-3-carboxamide 0.05
(E) polyoxyethylene (20) hydrogenated castor oil 0.5
(E) polyoxyethylene (5) lauryl ether 0.5
(E) sodium lauryl sulfate 1.2
Sorbitol 35
Propylene glycol 4
Polyethylene glycol 4000 0.4
abrasive silica 10
Thickening silica 3
Xanthan gum 0.3
Sodium alginate 0.8
Carrageenan 1
Methyl paraoxybenzoate 0.18
Titanium oxide 0.5
Citric acid 0.1
sodium hydroxide 0.24
Sodium monofluorophosphate 1.1
Isopropylmethylphenol 0.1
Saccharin sodium 0.18
Perfume 0.5
Remainder of purified water
Total 100.0%

Claims (13)

(A) Sichuan pepper extract,
(B) cineole and (C) (C1) citral
An oral composition containing The oral composition according to claim 1, wherein (B)/(A) is 0.2 to 500 as a mass ratio. 3. The oral cavity composition according to claim 1, wherein ( C1)/(A) is 0.01 to 50 as a mass ratio. The oral composition according to any one of claims 1 to 3, further comprising (C2) limonene as component (C). 5. The oral composition according to claim 4, wherein (C2)/(A) is 1 to 3,000 as a mass ratio. 6. The oral cavity composition according to claim 4, wherein the content of component (C2) is 0.05 to 10% by mass. The oral cavity composition according to any one of claims 1 to 6, wherein the content of component (A) is 0.001 to 0.1 mass% as a pure content. The oral cavity composition according to any one of claims 1 to 7 , wherein the content of component (B) is 0.01 to 2% by mass. The oral cavity composition according to any one of claims 1 to 8 , wherein the content of component (C1) is 0.001 to 0.2% by mass. The oral cavity composition according to any one of claims 1 to 9 , further comprising (D) a cooling agent in an amount of 0.001 to 2% by mass. (D) the cooling agent is N-ethyl-p-menthane-3-carboxamide, N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide and N-(2-(2-pyridinyl) The oral composition according to claim 10 , which is one or more p-menthane-3-carboxamides selected from ethyl)-2-isopropyl-5-methylcyclohexanecarboxamides. The oral composition according to any one of claims 1 to 11 , further comprising (E) a surfactant in an amount of 0.1 to 5% by mass. The oral composition according to any one of claims 1 to 12 , which is a dentifrice, mouthwash or mouthspray.