JP2023057209A - Non-aqueous oral composition - Google Patents

Abstract

To inhibit or alleviate the occurrence of a harsh taste felt in the use of an enzyme-containing non-aqueous oral composition.SOLUTION: A non-aqueous oral composition is provided which contains: an enzyme as component (A); and at least one cooling agent as component (B) selected from a group consisting of N-ethyl-p-menthane-3-carboxamide, 3-l-menthoxypropane-1,2-diol, N-(4-cyanomethylphenyl)-p-menthane carboxamide, (1R, 2S, 5R)-5-methyl-2-propan-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3-carboxamido)ethyl acetate, 2-isopropyl-N,2,3-trimethyl-butylamide, menthyl lactate, menthyl monosuccinate, isopulegol and menthone glycerol ketal.SELECTED DRAWING: None

Description

The present invention relates to non-aqueous oral compositions.

By using a non-aqueous solvent instead of water as a solvent for the dentifrice, it is possible to impart a warm sensation to the dentifrice due to the heat of hydration of the solvent. Such non-aqueous dentifrices are blended with enzymes capable of decomposing and removing dental plaque (for example, Patent Documents 1 and 2).

Here, when an enzyme is added to a non-aqueous dentifrice, a harsh feeling may be felt at the beginning of brushing due to the poor dispersibility peculiar to a non-aqueous dentifrice, and the usability may be deteriorated. In order to eliminate such disadvantages, a cooling agent is added. In Patent Document 3, a dentifrice composition containing an enzyme and an anionic surfactant is blended with a hydroxyethyl cellulose dimethyl diallyl ammonium salt and a predetermined fragrance composition to improve the retention of the enzyme in the oral cavity and cause liquid separation. can be suppressed. Patent Document 4 describes a non-aqueous toothpaste containing polyvinylpyrrolidone having a prescribed number average molecular weight, prescribed glycols, and an enzyme. Patent Document 4 describes that enzymes such as glucose oxidase and flavoring agents such as peppermint oil and spearmint oil may be included.

Japanese Patent No. 4723068 Japanese Patent No. 4803889 JP-A-2002-187829 Japanese translation of PCT publication No. 2013-512897

However, with conventional techniques such as those disclosed in Patent Documents 3 and 4, it is difficult to sufficiently suppress the occurrence of harshness when adding enzymes. An object of the present invention is to suppress or alleviate the occurrence of harshness during use in a non-aqueous oral cavity composition containing an enzyme.

The present inventors provide the following [1] to [8].
[1] Component (A): Enzyme, and Component (B): N-ethyl-p-menthane-3-carboxamide, 3-l-menthoxypropane-1,2-diol, N-(4-cyanomethylphenyl )-p-menthanecarboxamide, (1R, 2S, 5R)-5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane -3 carboxamide) at least one cooling agent selected from the group consisting of ethyl acetate, 2-isopropyl-N, 2,3-trimethylbutyramide, menthyl lactate, menthyl monosuccinate, isopulegol, and menthone glycerol ketal Non-aqueous oral composition containing.
[2] Component (C): The non-aqueous oral composition according to [1], further comprising a glycerin fatty acid ester.
[3] The non-aqueous oral composition according to [1] or [2], wherein the content of component (B) is 0.0001 to 0.3% by mass.
[4] The non-aqueous oral composition according to any one of [1] to [3], wherein component (A) contains at least one selected from the group consisting of glucanase, oxygenase, and protease.
[5] the glucanase is dextranase or mutanase;
the oxygenase is laccase, lactoperoxidase, or glucose oxidase; and
The non-aqueous oral composition according to [4], wherein the protease is papain, actinidin, bromelain, or nattokinase.
[6] Component (D): Any one of [1] to [5] further containing at least one polyhydric alcohol selected from the group consisting of polyethylene glycol, glycerin, diglycerin, propylene glycol, and polypropylene glycol The non-aqueous oral composition according to the item.
[7] The ratio of the enzyme titer of component (A) to the content of component (B) (A/B ratio) is 6,000 to 200,000,000 units/g [1]- The non-aqueous oral composition according to any one of [6].
[8] The non-aqueous oral composition according to any one of [1] to [7], which is a dentifrice, mouthwash, mouth spray, oral moisturizing gel, cream or cream mouth spray.

ADVANTAGE OF THE INVENTION According to this invention, the non-aqueous composition for oral cavity which can suppress or alleviate generation|occurrence|production of harshness at the time of use is provided in spite of containing an enzyme.

[1. Oral composition]
The composition contains the following components (A) and (B), and preferably further contains component (C).

[(A) component: enzyme]
The (A) component is an enzyme.
Enzymes are usually hydrolases and oxidoreductases (oxygenases). Among them, enzymes involved in the inhibition and prevention of caries progression in the oral cavity (e.g., decomposition of dental plaque, decomposition of causative components of bad breath, Enzymes involved in stain removal) are preferred. Such hydrolytic enzymes include, for example, glucanases and proteases.

-Glucanase-
Glucanases are enzymes that catalyze the hydrolysis of glycosidic bonds in glucans. Glucan, which is a substrate of glucanase, is composed of D-glucose bound by glycosidic bonds (e.g., α-1,3 bond, α-1,4 bond, α-1,6 bond, β-1,3 bond, β-1,4 bond). It is a polymer (polysaccharide of disaccharides or higher) having a structure linked by bonds, β-1,6 bonds). Glucans include, for example, α-glucans (eg, dextran, mutan, pullulan, amylopectin, glycogen, amylose), β-glucans (eg, cellulose, laminaran, curdlan, callose). The glucanase is preferably a glucanase that cleaves an α-1,3 bond and/or an α-1,6 bond, more preferably a dextranase or a mutanase. As a result, the glucan produced by Streptococcus mutans can be decomposed, and the decomposition and removal of dental plaque in the oral cavity can be realized. The origin of glucanase is not particularly limited, and it may be naturally derived from microorganisms, plants, animals, etc., or may be artificially prepared by genetic recombination, chemical synthesis, or the like. When the glucanase is dextranase, it may be derived from bacteria capable of producing dextranase (for example, bacteria belonging to the genera Chaetomium, Penicillium, Aspergillus, Spicaria, Lactobacillus, and Servibrio). Glucanase may be used singly or in combination of two or more.

－Protease－
Proteases are enzymes that catalyze the hydrolysis of peptide bonds in proteins. The protease may be either endopeptidase or exopeptidase (aminopeptidase, carboxypeptidase), but endopeptidase is preferred. Endoproteases include, for example, cysteine proteases such as papain, bromelain and actinidin, and serine proteases such as nattokinase. Cysteine proteases are preferred, and papain is more preferred. Papain has a high activity per unit mass, and a relatively small amount can exert an oral biofilm removal effect. The origin of the protease is not particularly limited, and it may be naturally derived from microorganisms, plants, animals, etc., or may be artificially prepared by genetic recombination, chemical synthesis, or the like. If it is naturally derived, its purity is not particularly limited, and it may contain components other than protease (eg, plant extract). When the protease is a cysteine protease, it is preferably derived from plants such as papaya, pineapple, and kiwi, but is not limited thereto, and may be derived from microorganisms such as Aspergillus and Bacillus. Proteases may be used singly or in combination of two or more.

-Oxidoreductase (oxygenase)-
Oxygenases are enzymes that catalyze redox. Oxygenases include, for example, polyphenol oxidase, glucose oxidase, and lactoperoxidase, with polyphenol oxidase being preferred. Polyphenol oxidase is an oxidase that oxidizes phenol compounds such as catechol, tyrosine, chlorogenic acid, dopa and pyrogallol. Examples of polyphenol oxidase include laccase, catechol oxidase, and monophenol oxidase, with laccase being preferred. The origin of oxygenase is not particularly limited, and it may be naturally derived from microorganisms, plants, animals, etc., or may be artificially prepared by genetic recombination, chemical synthesis, or the like. If it is naturally derived, its purity is not particularly limited, and it may contain components other than oxygenase (eg, plant extract). When the oxygenase is a polyphenol oxidase, it is preferably derived from white rot fungi (eg, Tremetes spp.). You may use oxygenase individually by 1 type or in combination of 2 or more types.

- Enzyme titer of component (A) -
The enzyme titer of component (A) (in the case of a combination of two or more enzymes, the enzyme titer of each enzyme) is preferably 2 units/g or more, more preferably 10 units/g or more. Thereby, plaque can be decomposed and removed more efficiently. The upper limit is preferably 200 units/g or less, more preferably 50 units/g or less. As a result, it is possible to suppress the occurrence of harshness during use. Therefore, it is preferably 2 to 200 units/g, more preferably 10 to 50 units/g.

In the enzymatic titer, 1 unit is based on the definition of "international unit" of the 1964 International Union of Biochemistry, "under optimal conditions, 1 μmol of substrate is changed in 1 minute at a temperature of 30 ° C. in 1 L of sample. The amount of enzyme that can be produced” (see https://www.jslm.org/committees/standard/standard_Q&A.pdf).

[(B) component: cooling agent]
The component (B) is a cooling agent. Component (B) is, for example, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3 -l-menthoxypropane-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3 carboxamido) ethyl acetate, 2-isopropyl-N, 2,3-trimethylbutyramide, and a combination of two or more selected from these. Among these, N-ethyl-p-menthane-3-carboxamide, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-menthoxypropane-1,2-diol, 5-methyl-2 -propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide and ethyl 3-(p-menthane-3carboxamido)acetate are preferred.

- Content of component (B) -
The content of component (B) is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, and even more preferably 0.01% by mass or more, relative to the total amount of the composition. As a result, it is possible to suppress the occurrence of harshness during use, and to realize a good feeling of use. The upper limit is preferably 0.3% by mass or less, more preferably 0.2% by mass or less. As a result, the bitterness can be suppressed and a good feeling of use can be realized. Therefore, the content of component (B) is preferably 0.0001 to 0.3% by mass, more preferably 0.001 to 0.3% by mass, even more preferably 0.01 to 0.2% by mass.

[A/B ratio]
The ratio of the contents of components (A) and (B) (A/B ratio) can be expressed as the ratio (unit/g) of the enzyme titer of component (A) to the content of component (B). , preferably 6,000 units/g or more, more preferably 10,000 units/g or more, and the upper limit is preferably 200,000,000 units/g or less, more preferably 500,000 units/g or less. be. Accordingly, the A/B ratio is preferably between 6,000 and 200,000,000 units/g, more preferably between 10,000 and 500,000 units/g. As a result, the content of component (A) can be appropriately adjusted, and harshness during use can be improved.

[(C) component: glycerin fatty acid ester]
(C) Component is a glycerin fatty acid ester. The glycerin fatty acid ester may be monoester, diester or triester, preferably glycerin fatty acid triester (fatty acid triglyceride). The number of carbon atoms in the fatty acid-derived portion is preferably 4-22, more preferably 6-16, still more preferably 6-12, still more preferably 8-10. Fatty acids may be either unsaturated or saturated fatty acids, branched-chain fatty acids, or straight-chain fatty acids. Examples include caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, oleic acid, and linoleic acid. be done. The fatty acid components constituting the glycerin fatty acid diester and triester may be different from each other, or may be common to all three types. The glycerin fatty acid ester may be added to the preparation alone or may be present as a component in the perfume. Component (C) may be used alone or in combination of two or more.

- Content of component (C) -
The content of component (C) is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, relative to the total amount of the composition. As a result, it is possible to suppress the occurrence of harshness during use. The upper limit is preferably 3% or less, more preferably 2% or less. As a result, deterioration in quality such as discoloration can be suppressed. Therefore, the content of component (C) is preferably 0.001 to 3% by mass, more preferably 0.01 to 2% by mass.

[(D) component: polyhydric alcohol]
(D) A component is a polyhydric alcohol. (D) Component is the position of the solvent in the non-aqueous oral composition. Polyhydric alcohols are typically liquid polyhydric alcohols at 25° C. that generate heat of hydration when in contact with water. Such polyhydric alcohols include, for example, polyethylene glycol, glycerin, diglycerin, propylene glycol, polypropylene glycol, or a combination of two or more thereof, preferably polyethylene glycol, glycerin, diglycerin, propylene glycol, glycerin, More preferred are polyethylene glycol and butylene glycol. As a result, the sensation of warmth is improved, and the degrease feeling in the oral cavity can be improved.

-Glycerin-
Polyhydric alcohols usually have a bitter taste, but glycerin is relatively less bitter. Therefore, when the component (D) contains at least glycerin, the bitterness of the composition can be suppressed. The glycerin content is preferably 20% by mass or more, more preferably 50% by mass or more, relative to the entire component (D). As a result, the appearance of the composition is improved, and the viscosity can be adjusted to an appropriate level. The upper limit may be 100% by mass or less, preferably 85% by mass or less, and more preferably 80% by mass or less. Thereby, the bitterness derived from the component (D) can be suppressed. Therefore, the content of glycerin is preferably 20 to 100% by mass, more preferably 50 to 85% by mass, still more preferably 50 to 80% by mass, based on the total component (D).

-Average molecular weight of polyethylene glycol-
The average molecular weight of polyethylene glycol (the average molecular weight described in Standards for Quasi-Drug Ingredients 2006, the same shall apply hereinafter) is preferably 190-630. Polyethylene glycol having the above-mentioned average molecular weight contributes relatively strongly to the sensation of warmth, so that the intensity of the sensation of warmth can be enhanced. Examples of such polyethylene glycol include polyethylene glycol 200 (average molecular weight 190-210), polyethylene glycol 400 (average molecular weight 380-420), and polyethylene glycol 600 (average molecular weight 570-630).

-Polyethylene glycol content-
The content of polyethylene glycol (preferably polyethylene glycol having an average molecular weight of 190 to 630) is preferably 10% by mass or more, more preferably 15% by mass or more, based on the total amount of the composition. Thereby, the influence of the bitterness derived from polyethylene glycol on the feeling of use can be suppressed. The upper limit is preferably 30% by mass or less. Therefore, it is preferably 10% by mass or more, more preferably 15 to 30% by mass.

-Preferred embodiment of component (D)-
Preferred embodiments of component (D) include the following:
(1) combination system of glycerin and polyethylene glycol having an average molecular weight of 190-630; and (2) combination system of glycerin, polyethylene glycol having an average molecular weight of 190-630 and butylene glycol.
Among these, (1) is preferable, and in (1), the content of glycerin is 50% or more, preferably 50 to 85%, of the total amount of component (D) is more preferable.

- Content of component (D) -
The content of component (D) is generally 20% by mass or more, preferably 40% by mass or more, relative to the total amount of the composition. Thereby, deterioration of the appearance of the composition can be suppressed. The upper limit is usually 90% by mass or less, preferably 85% by mass or less, more preferably 80% by mass or less, relative to the total amount of the composition. As a result, an excessive decrease in viscosity can be suppressed, and a good feeling of use can be maintained. Accordingly, the content of component (D) is generally 20 to 90% by mass, preferably 20 to 85% by mass, more preferably 40 to 80% by mass.

[Non-aqueous]
The composition is a non-aqueous oral composition. As used herein, the term "non-aqueous system" means substantially free of water. preferable. The water content in the non-aqueous oral composition is usually 2% by mass or less, preferably 1% by mass or less, and more preferably 0.5% by mass or less. The water content of the oral composition is the ratio (% by mass) of the total water content contained in the raw materials before blending to the total raw materials, or the difference between the dry weight and the dry weight of the oral composition. It can be calculated as a ratio (% by mass) to the original weight.

〔viscosity〕
The viscosity (25° C.) of the composition is preferably 20 to 100 Pa·s, more preferably 30 to 90 Pa·s, still more preferably 35 to 80 Pa·s, still more preferably 35 to 70 Pa·s, and 40 to 60 Pa·s. s is particularly preferred. Toki Sangyo Co., Ltd. (model: VISCOMETER TVB-10), rotor No. 6 or 7, and measured at 20 rpm for 3 minutes at 25°C.

[Optional component]
The composition may contain other components other than the components (A) to (D) as long as the effects of the present invention are not impaired. Other ingredients include, for example, surfactants, sweeteners, flavors, wetting agents, binders, abrasives, pH adjusters, preservatives, medicinal ingredients, oily ingredients, colorants (pigments), and other oral compositions. Ingredients that can be incorporated into the product include, but are not limited to.

-Surfactant-
Examples of surfactants include anionic surfactants, amphoteric surfactants, and nonionic surfactants. Anionic surfactants and amphoteric surfactants are preferred because they can further improve the rising of the warm feeling. Activators are more preferred.

Anionic surfactants include, for example, alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, and lauryl sulfoacetate. Alkyl groups and acyl groups may be linear or branched, saturated or unsaturated, and usually have 10 to 20 carbon atoms, preferably 12 to 18 carbon atoms, and more preferably 14 to 16 carbon atoms. Salts may be selected from pharmacologically acceptable salts. Pharmaceutically acceptable salts include, for example, base addition salts and amino acid salts. Specific examples thereof include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts and diisopropylammonium salts; arginine salts and the like. and basic amino acid salts of Among them, inorganic base salts are preferred, alkali metal salts (eg, sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Alkyl sulfates include, for example, lauryl sulfate and myristoyl sulfate. Acyl amino acid salts include, for example, acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate and palmitoyl glutamate; N-lauroyl-N-methylglycinate and cocoylglycine. Acylglycine salts such as salts; N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl acylalanine salts such as -N-methyl-β-alanine salts and N-methyl-N-acylalanine salts; and acyl aspartates such as lauroyl aspartate. Acyl taurine salts include, for example, lauroyl methyl taurine salts, N-methyl-N-acyl taurine salts, and N-cocoyl methyl taurine salts. The α-olefin sulfonate includes α-olefin sulfonates having 12 to 18 carbon atoms such as tetradecene sulfonate (α-olefin sulfonic acid having 14 to 16 carbon atoms). Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate.

As the anionic surfactant, an α-olefin sulfonate is preferable, and a tetradecene sulfonate (α-olefin sulfonic acid having 14 to 16 carbon atoms) is more preferable. Anionic surfactants may be used alone or in combination of two or more.

When the anionic surfactant is included, the content thereof is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, based on the total composition. As a result, the dispersibility of the preparation in the oral cavity is improved during use, and the warm feeling is improved. The upper limit is preferably 3% by mass or less, more preferably 2% by mass or less. This can reduce the feeling of degreasing in the oral cavity after use. Therefore, it is preferably 0.1 to 3% by mass, more preferably 0.5 to 2% by mass of the total composition.

Examples of amphoteric surfactants include betaine type and amino acid type, with betaine type being preferred. Examples of betaine-type amphoteric surfactants include fatty acid amidopropyl betaine (eg, coconut oil fatty acid amidopropyl betaine), alkyl acetate betaine (eg, alkyl amino acetate betaine such as lauryldimethylamino acetate betaine), and alkylimidazolinium betaine. (eg, alkylcarboxymethylhydroxyethylimidazolinium betaines), fatty acid amidopropylbetaines and alkylacetate betaines are preferred, and coconut oil fatty acid amidopropylbetaines are more preferred. When the amphoteric surfactant has an alkyl group or an acyl group, they may be linear or branched, saturated or unsaturated, and usually have 10 to 20 carbon atoms, preferably 12 to 18 carbon atoms. , more preferably 14-16. The amphoteric surfactant is preferably a solution or powder with a pure content (betaine pure content) of 65% or more. This can facilitate adjustment of the moisture content of the composition.

As the amphoteric surfactant, fatty acid amidoalkyl betaine is preferable, and fatty acid amidopropyl betaine such as coconut oil fatty acid amidopropyl betaine is more preferable. Amphoteric surfactants may be used alone or in combination of two or more.

When the amphoteric surfactant is included, the content thereof is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, based on the total composition. As a result, the feeling of degreasing in the oral cavity is sufficiently improved, and the rise of the feeling of warmth is improved. The upper limit is preferably 3% by mass or less, more preferably 2% by mass or less. As a result, the bitterness is suppressed, and the pleasant feeling of use can be sufficiently maintained. Therefore, 0.1 to 3% by mass is preferable, and 0.3 to 2% by mass is more preferable.

Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oils, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene Ethylene fatty acid ester, polyoxyethylene alkenyl ether, glycerin fatty acid ester, sucrose fatty acid ester (eg, maltose fatty acid ester), sugar alcohol fatty acid ester (eg, maltitol fatty acid ester, lactitol fatty acid ester), fatty acid diethanolamide (eg, lauryl) acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters, polyoxyethylene polyoxypropylene (EOPO) copolymers, alkyl glucosides, fatty acid polyglyceryls. The number of carbon atoms in the alkyl group of the polyoxyethylene alkyl ether is generally 12 to 18, preferably 14 to 18 (eg, lauryl and stearyl groups), and the average number of added moles of ethylene oxide is generally 5 to 30 mol, preferably is 15-30 mol. The average mole number of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is generally 5 to 100 mol, preferably 20 to 100 mol, more preferably 20 to 60 mol. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12-18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is generally 16-18, and the average number of moles of ethylene oxide added is generally 10-40 mol. The alkyl chain of the alkylolamide usually has 12-14 carbon atoms. The polyoxyethylene-polyoxypropylene (EOPO) copolymer preferably has an average added mole number of ethylene oxide of 20 to 210 and an average added mole number of propylene oxide of 15 to 60, and may be a block copolymer or a random copolymer.

The content of the nonionic surfactant is preferably 0.05% by mass or more, more preferably 0.5% by mass or more, based on the total composition. As a result, the feeling of degreasing in the oral cavity can be improved. The upper limit is preferably 2% by mass or less, more preferably 1% by mass or less. As a result, the bitterness can be suppressed, and the pleasant feeling of use can be sufficiently maintained. Therefore, it is preferably 0.05 to 2% by mass, more preferably 0.5 to 1% by mass.

-sweetener-
Sweeteners include, for example, xylitol, erythritol, maltitol, saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester, p- methoxycinnamic aldehyde and the like. A sweetener may be used individually by 1 type, and may be used in combination of 2 or more type.

-Perfume-
Peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime. Oil, Lavender Oil, Rosemary Oil, Laurel Oil, Chamomile Oil, Caraway Oil, Marjoram Oil, Bay Oil, Lemongrass Oil, Origanum Oil, Pine Needle Oil, Neroli Oil, Rose Oil, Jasmine Oil, Iris Concrete, Absolute Peppermint , absolute rose, orange flower, etc., and processed (pre-reservoir cut, post-reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder perfume, etc.) processing of these natural perfumes, and menthol , carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, Carbyl Acetate, Anisaldehyde, Ethyl Acetate, Ethyl Butyrate, Allylcyclohexane Propionate, Methyl Anthranilate, Ethyl Methyl Phenyl Glycidate, Vanillin, Undecalactone, Hexanal, Propyl Alcohol, Butanol, Isoamyl Alcohol, Hexenol, Dimethyl Sulfide, Cyclotene, Furfural, Trimethylpyrazine, Ethyllactate, Methyllactate, Ethylthioacetate, etc., Strawberry Flavor, Apple Flavor, Banana Flavor, Pineapple Flavor, Grape Flavor, Mango Flavor, Butter Flavor, Milk Flavor, Fruit Mixed flavors, tropical fruit flavors, and other mixed flavors can be used. Perfume may be used individually by 1 type, and may be used in combination of 2 or more type.

It is preferable to use 0.000001 to 1% by mass of the above perfume material in the composition, and 0.1 to 2.0% by mass of the perfume for perfuming using the above perfume material is used in the composition. It's good.

-wetting agent-
As the humectant, polyhydric alcohols other than the polyhydric alcohols exemplified as component (D) are preferred, and examples thereof include sugar alcohols such as sorbitol (sorbitol); glycols such as ethylene glycol; and reduced starch saccharification products. One type of wetting agent may be used, or two or more types may be used in combination. The average molecular weight is the average molecular weight described in the Standards for Quasi-drug Ingredients 2006.
The content of the wetting agent is usually 0-20% by weight, preferably 1-10% by weight.

-Binder-
As the binder, an organic binder such as a water-soluble polymer or an inorganic binder can be used. Organic binders include, for example, cellulose-based binders (e.g., carboxymethylcellulose (CMC), sodium salts thereof, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc.), and other polysaccharides. Binders (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, gum arabic, locust bean gum, carrageenan, sodium alginate), synthetic water-soluble polymers (e.g., (cross-linked) sodium polyacrylate, carboxyvinyl polymer, polyvinyl alcohol, propylene glycol alginate). Examples of the inorganic binder include thickening silica such as precipitated silica, igneous silica, gelling silica, and gelling aluminum silica; and clay minerals such as Veegum, laponite, and bentonite. More preferred are cellulose-based binders, other polysaccharide-based binders, and synthetic water-soluble polymers, and still more preferred are sodium carboxymethylcellulose, carrageenan, and carboxyvinyl polymer. 1 type of caking agents may be sufficient and 2 or more types of combinations may be sufficient as them.
The content of the binder is preferably 0.1 to 3% by mass, more preferably 0.1 to 2% by mass, based on the total composition.

-Abrasive-
The abrasive may be, for example, either an inorganic abrasive or an organic abrasive. Examples of inorganic abrasives include abrasive silica such as aluminosilicate, zirconosilicate, crystalline zirconium silicate, and titanium-bonded silica; dicalcium phosphate dihydrate or anhydrate, monocalcium phosphate, and tricalcium phosphate. Calcium phosphate-based compounds such as calcium pyrophosphate; Calcium carbonate-based abrasives such as calcium carbonate; Calcium-based abrasives other than carbonate/phosphoric acid, such as calcium hydroxide and calcium sulfate; Aluminum oxide, aluminum hydroxide, alumina and the like Silicic acid-based materials such as silicic anhydride, zeolite, and zirconium silicate; Magnesium-based materials such as magnesium carbonate and trimagnesium phosphate; Apatite-based materials such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; Titanium dioxide , mica titanium, titanium oxide and other titanium-based materials; and bentonite and other minerals. Examples of organic abrasives include polymethyl methacrylate and synthetic resin abrasives. Among these, abrasive silica and calcium phosphate compounds are preferable, and abrasive silica is more preferable. One type of abrasive may be used, or two or more types may be used in combination.
The compounding amount of the abrasive is usually 0 to 70% by mass, preferably 2 to 30% by mass, based on the total composition.

-pH adjuster-
Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, salts thereof, inorganic acids such as phosphoric acid (orthophosphoric acid), and salts thereof. (for example, potassium salt, sodium salt and ammonium salt), sodium hydroxide, potassium hydroxide and the like. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate. The content of the pH adjuster is usually such that the pH of the composition after addition is 5 to 9, preferably 6 to 8.5. In this specification, the pH value is generally the value after 3 minutes at 25° C. from the start of measurement, and can be measured using a pH meter (Model Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

-Preservative-
Examples of antiseptics include paraoxybenzoic acid esters (eg, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, and the like. The preservatives may be used singly or in combination of two or more.

-Medicinal Ingredients-
Examples of medicinal ingredients include nonionic fungicides (eg, isopropylmethylphenol), cationic fungicides (eg, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride), zinc gluconate, zinc citrate, triclosan, Bactericidal or antibacterial agents such as hinokitiol, lysozyme chloride, chlorhexidine salts, trichlorocarbanilide; fluorides such as sodium fluoride, sodium monofluorophosphate, tin fluoride; ε-aminocaproic acid, allantoins (e.g., allantoin, allantoin) aluminum chlorohydroxyl), tranexamic acid, azulene, dihydrocholesterol, α-bisabolol, glycyrrhizin, glycyrrhetinic acid, berberine, anti-inflammatory agents such as epidihydrocholesterin; metal salts such as zinc, copper salts, tin salts; water-soluble phosphate compounds such as potassium salts and sodium salts; chelating phosphate compounds such as glycerophosphate; anticalculus agents such as condensed phosphates and ethanehydroxydiphosphonate; vitamin E (e.g., dl-α-acetic acid Blood flow promoters such as tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, strontium chloride; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; vitamin C (e.g., ascorbic acid or its salt), astringents such as sodium chloride; copper compounds such as copper chlorophyll and copper gluconate; anticalculus agents, amino acids such as alanine, glycine, proline; Plant extracts such as thyme, scutellaria root, clove, hamamelis; calopeptide, polyvinylpyrrolidone, hydroxamic acid and its derivatives, tripolyphosphate, methoxyethylene maleic anhydride copolymer, sodium chloride, chlorophyll, sanguinarine extract, berberine, hydroxamic acid and Mention may be made of its derivatives, pyrophosphates, zeolites, epidihydrocholesterin, trichlorocarbanilides, zinc citrate. A medicinal ingredient may be used individually by 1 type, and may be used in combination of 2 or more type. The content of the medicinal ingredient can be appropriately set to an effective amount according to a conventional method within a range that does not impair the effects of the present invention.

- Oily component -
Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, microcrystalline wax, carnauba wax, rice wax, and rosin; higher alcohols (such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, iso Alcohols with 8 to 22 carbon atoms such as stearyl alcohol); higher fatty acids (for example, fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, isostearic acid), olive oil, castor oil, coconut oil, etc. and fatty acid esters such as isopropyl myristate.

-coloring agent-
Examples of coloring agents include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, monascus pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, tamarind pigment, Legal pigments such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, Blue No. 4, riboflavin, Copper chlorophyllin sodium etc. are mentioned.
When the non-aqueous oral composition contains a coloring agent, the content thereof is preferably 0.00001 to 3% by mass based on the total non-aqueous oral composition.

The composition includes dentifrices such as toothpaste, gel-like dentifrice, liquid dentifrice, liquid dentifrice, and toothpaste, oral coating agents such as oral moisturizing gel and oral cream, mouth spray, and mouthwash. as a toothpaste, preferably a toothpaste.

The dosage form of the composition can be appropriately selected according to the usage form, and is not particularly limited. Dosage forms include, for example, gels, pastes, and liquids.

[2. Method for manufacturing the composition]
The method for producing the composition is not particularly limited, and it can be prepared by a conventional method depending on the dosage form. For example, when it is used as a toothpaste, a method of preparing components that dissolve in a solvent, mixing other insoluble components, and degassing (for example, reducing pressure, etc.) as necessary. The obtained toothpaste can be stored in a container to be used as a product. The shape and material of the container are not particularly limited, and containers commonly used for toothpaste compositions can be used. Examples thereof include plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon.

EXAMPLES The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, % in the table indicates % by mass unless otherwise specified.

[Main raw materials used in Examples and Comparative Examples]
(A-1) Dextranase: Daiichi Sankyo Propharma Co., Ltd., 13,000 units / g
(A-2) Laccase: Amano Enzyme Co., Ltd., "Laccase Daiwa" (derived from white rot fungus (Trametes sp.))
(A-3) Papain: Mitsubishi Kagaku Foods Co., Ltd., "purified papain"
(A-4) Mutanase: Amano Enzyme Co., Ltd., "Mutanase"
(A-5) Lactoperoxidase: Sigma-Aldrich, "lactoperoxidase from bovine milk"
(A-6) glucose oxidase: manufactured by Sigma-Aldrich, "glucose oxidase from Aspergillus niger"
(A-7) actinidin: manufactured by BNH Co., Ltd., "Zactinase (registered trademark)"
(A-8) Bromelain: “Bromelain” manufactured by Godo Shusei Co., Ltd.
(A-9) Nattokinase: "Natto bacteria culture extract NSK-SD" manufactured by Japan Biological Science Laboratory Co., Ltd.
(B-1) N-ethyl-p-menthane-3-carboxamide: "WS-3" manufactured by Givaudan
(B-2) N-(4-cyanomethylphenyl)-p-menthanecarboxamide: manufactured by Givaudan, "Evercool (registered trademark) G-180"
(B-3) 3-l-menthoxypropane-1,2-diol: manufactured by Takasago International Corporation, "CA-10"
(C) fatty acid triglyceride: Fuji Oil Co., Ltd., "medium chain fatty acid triglyceride"
(D-1) Concentrated glycerin: Sakamoto Pharmaceutical Co., Ltd., "Concentrated glycerin for cosmetics (99.5%)"
(D-2) Polyethylene glycol 400: manufactured by Sanyo Chemical Industries, Ltd., "Polyethylene glycol 400"
CMC (sodium carboxymethylcellulose): "CMC1260" manufactured by Daicel Finechem Co., Ltd.
SDS (sodium dodecyl sulfate): manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., "sodium dodecyl sulfate"
Silica: "Tixosil (registered trademark) 73" manufactured by Solvay
For other ingredients, those conforming to the Standards for Quasi-drug Ingredients 2006 were used.

Examples 1-35 and Comparative Examples 1-2 (toothpaste)
A toothpaste was prepared according to the following preparation method. The formulation composition of each example is shown in Tables 1-6. When the water content of the composition was calculated as the ratio (% by mass) of the total water content contained in the raw materials before blending to the total raw materials, it was 2% by mass or less. The amount of enzyme preparation used in each composition was 100 g.

[Method for preparing dentifrice composition]
Raw materials were blended by a conventional method, mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kosakusho Co., Ltd.), and degassed under reduced pressure (pressure 4 kPa) to obtain a dentifrice composition.

The obtained dentifrice composition was evaluated by the following procedures.

[Evaluation method]
－Evaluation of sharpness at the beginning of polishing－
When 1 g of the dentifrice composition is placed on a toothbrush (clinica advantage toothbrush, 4-row compact normal, manufactured by Lion Corporation) and brushed in the usual manner, the harshness at the beginning of brushing is evaluated in 4 stages according to the following rating criteria. evaluated. The average score of the 7 testers was calculated and shown in the table as *, .circleincircle., .smallcircle., .DELTA.

(Rating criteria)
4 points: no harshness at the beginning of polishing is felt 3 points: slight harshness at the beginning of polishing is felt 2 points: the harshness at the beginning of polishing is felt 1 point: the harshness at the beginning of polishing is strongly felt (evaluation criteria)
★: Average 3.5 or more ◎: Average 3.0 or more and less than 3.5 〇: Average 2.5 or more and less than 3.0 △: Average 2.0 or more and less than 2.5 ×: Average 2 Less than 0 points

In Comparative Examples 1 and 2 containing component (A) but not containing component (B), harshness was felt at the beginning of polishing. Acne was suppressed. Examples 10 to 25, 27, and 29 to 35, which further contained component (C) in addition to components (A) and (B), were excellent in lack of harshness at the beginning of polishing.

Formulation examples are shown below.

Formulation Example 1: Mouthwash (A-1) Dextranase (unit/g) 20
(B-1) N-ethyl-p-menthane-3-carboxamide 0.07
(C) Fatty acid triglyceride 0.6
(D-1) Concentrated glycerin (99.5%, manufactured by Sakamoto Yakuhin Kogyo) Balance (D-2) Polyethylene glycol 400 20
(D-3) propylene glycol 10
Saccharin sodium 0.01
Methylparaben 0.1
Total 100
(A)/(B) = 20000

Formulation Example 2: Mouthwash (A-1) Dextranase (unit/g) 20
(B-1) N-ethyl-p-menthane-3-carboxamide 0.07
(C) Fatty acid triglyceride 0.6
(D-1) Concentrated glycerin (99.5%, manufactured by Sakamoto Yakuhin Kogyo) Balance (D-2) Polyethylene glycol 400 20
(D-3) propylene glycol 10
Saccharin sodium 0.01
Methylparaben 0.1
Total 100
(A)/(B) = 20000

Formulation Example 3: Mouthwash (A-1) Dextranase (unit/g) 20
(B-2) N-(4-cyanomethylphenyl)-p-menthanecarboxamide
0.07
(C) Fatty acid triglyceride 0.6
(D-1) Concentrated glycerin (99.5%, manufactured by Sakamoto Yakuhin Kogyo) Balance (D-2) Polyethylene glycol 400 30
(D-3) propylene glycol 10
Saccharin sodium 0.01
Methylparaben 0.1
Total 100
(A)/(B) = 20000

Formulation Example 4: Mouthwash (A-1) dextranase (unit/g) 20
(B-3) 3-l-menthoxypropane-1,2-diol 0.07
(C) Fatty acid triglyceride 0.6
(D-1) Concentrated glycerin (99.5%, manufactured by Sakamoto Yakuhin Kogyo) Balance (D-2) Polyethylene glycol 400 30
(D-3) propylene glycol 10
Saccharin sodium 0.01
Methylparaben 0.1
Total 100
(A)/(B) = 20000

Formulation Example 5: Mouth Spray (A-1) Dextranase (unit/g) 20
(B-3) 3-l-menthoxypropane-1,2-diol 0.02
(C) Fatty acid triglyceride 0.6
(D-1) Concentrated glycerin (99.5%, manufactured by Sakamoto Yakuhin Kogyo) Balance (D-2) Polyethylene glycol 400 30
Saccharin sodium 0.01
Methylparaben 0.1
Total 100
(A)/(B) = 20000

Claims (8)

(A) component: enzyme, and (B) component: N-ethyl-p-menthane-3-carboxamide, 3-l-menthoxypropane-1,2-diol, N-(4-cyanomethylphenyl)-p - menthanecarboxamide, (1R,2S,5R)-5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3 carboxamide ) Ethyl acetate, 2-isopropyl-N, 2,3-trimethylbutyramide, menthyl lactate, menthyl monosuccinate, isopulegol, and a cooling agent containing at least one cooling agent selected from the group consisting of menthone glycerol ketal A water-based oral composition. (C) Component: The non-aqueous oral composition according to claim 1, further comprising a glycerin fatty acid ester. 3. The non-aqueous oral composition according to claim 1, wherein the content of component (B) is 0.0001 to 0.3% by mass. The non-aqueous oral composition according to any one of claims 1 to 3, wherein component (A) comprises at least one selected from the group consisting of glucanase, oxygenase, and protease. the glucanase is dextranase or mutanase;
the oxygenase is laccase, lactoperoxidase, or glucose oxidase; and
5. The non-aqueous oral composition according to claim 4, wherein the protease is papain, actinidin, bromelain, or nattokinase. (D) component: polyethylene glycol, glycerin, diglycerin, propylene glycol, and non-non-polarizing according to any one of claims 1 to 5 further containing at least one polyhydric alcohol selected from the group consisting of polypropylene glycol A water-based oral composition. Any one of claims 1 to 6, wherein the ratio of the enzyme titer of component (A) to the content of component (B) (A/B ratio) is 6,000 to 200,000,000 units/g. 1. The non-aqueous oral composition according to 1. The non-aqueous oral composition according to any one of claims 1 to 7, which is a dentifrice, mouthwash, mouthspray, oral moisturizing gel, or cream.