JPWO2020016926A1 - Non-aqueous oral composition - Google Patents

Abstract

The non-aqueous oral composition of the present invention is a non-aqueous oral composition containing hydroxypropyl cellulose and is selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol. When the content of at least one specific non-aqueous solvent is 30% by mass or more and 85% by mass or less, and the content of the alkiloylalkyltaurine salt-type anionic surfactant is 0.1% by mass or more and 10% by mass or less. It is characterized in that the content of the alkylamide propyl betaine type amphoteric surfactant is 0.1% by mass or more and 10% by mass or less.

Description

The present invention relates to non-aqueous oral compositions.

Conventionally, as a means for preventing a specific content component from being denatured in the presence of water during storage or the like, a non-aqueous system having a low content rate even when water is substantially not contained or is contained. Oral compositions are used. In addition, the non-aqueous oral composition contains a thickener such as hydroxypropyl cellulose, carrageenan, and carnauba wax together with a relatively polar non-aqueous solvent other than water to secure the properties and shape of the composition. ..

Further, when hydroxypropyl cellulose was used together with the solvent, there was a problem of solid-liquid separation during high-temperature storage.

On the other hand, in order to enhance the detergency and foaming power of the oral composition, an alkyl sulfate-based anionic surfactant such as sodium lauryl sulfate has been blended (for example, Patent Document 1 and Patent Document 2). reference).

Although sodium lauryl sulfate has high foaming power, it is highly irritating to the oral mucosa and gums. Further, since the non-aqueous oral composition does not substantially contain or contains water in the preparation itself, its content is low, so that there is a problem that the irritation of sodium lauryl sulfate to the oral mucosa is further increased. Further, when a foaming agent that is less irritating to the oral mucosa is selected, there is a problem that a satisfactory foaming amount cannot be obtained with a non-aqueous oral composition.

Japanese Patent No. 4520858 Japanese Patent No. 3929650

An object of the present invention is to provide a non-aqueous oral composition which is less likely to cause solid-liquid separation or hardening during high-temperature storage, has high foaming power, and is less irritating to the oral mucosa and toothpaste.

Such an object is achieved by the present invention of the following (1) to (6).
(1) A non-aqueous oral composition containing hydroxypropyl cellulose.
The content of the specific non-aqueous solvent, which is at least one selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol, is 30% by mass or more and 85% by mass or less.
The content of the alkiloyl alkyl taurine salt-type anionic surfactant is 0.1% by mass or more and 10% by mass or less.
A non-aqueous oral composition comprising an alkylamide propyl betaine type amphoteric tenside having a content of 0.1% by mass or more and 10% by mass or less.

(2) The non-aqueous oral composition according to (1) above, wherein the alkiloylalkyltaurine salt-type anionic surfactant is sodium lauroylmethyltaurine.

(3) The non-aqueous oral composition according to (1) or (2) above, wherein the alkylamide propyl betaine type amphoteric surfactant is cocamidopropyl betaine.

(4) When the content of the alkylylalkyltaurine salt-type anionic surfactant is X1 [mass%] and the content of the alkylamide propyl betaine-type amphoteric surfactant is X2 [mass%], 0. The non-aqueous oral composition according to any one of (1) to (3) above, which satisfies the relationship of 1 ≦ X1 / X2 ≦ 10.

(5) The non-aqueous oral composition according to any one of (1) to (4) above, further comprising xanthan gum in a content of 0.1% by mass or more and 5.0% by mass or less.

(6) The non-aqueous oral composition according to any one of (1) to (5) above, further containing hydroxypropylmethylcellulose at a content of 0.1% by mass or more and 5.0% by mass or less.

According to the present invention, the affinity between the non-aqueous solvent and hydroxypropyl cellulose is increased, solid-liquid separation and hardening are less likely to occur even during high-temperature storage, the foaming power is high, and the irritation to the oral mucosa and gums is low. An aqueous oral composition can be provided.

Hereinafter, preferred embodiments of the present invention will be described in detail.
<< Non-aqueous oral composition >>

Conventionally, an anionic surfactant based on sodium alkyl sulfate such as sodium lauryl sulfate has been blended as a foaming agent in the oral composition in order to enhance its detergency and foaming power.

However, although sodium lauryl sulfate has a high foaming power, it has a problem that it is highly irritating to the oral mucosa and the toothpaste in the non-aqueous oral composition.

Therefore, the present inventor has made it difficult for solid-liquid separation and hardening to occur in a non-aqueous oral composition during high-temperature storage, suppresses irritation to the oral mucosa and toothpaste, and exerts sufficient foaming power. I did a lot of research for the purpose. As a result, by using an alkyrylalkyltaurine salt-type anionic surfactant and an alkylamide propylbetaine-type amphoteric surfactant at a predetermined content, they act synergistically and are cured or non-aqueous during high-temperature storage. Non-aqueous system with low irritation to oral mucosa and gums, while achieving foaming power comparable to that of sodium lauryl sulfate without separation of solvent and hydroxypropyl cellulose and without sodium alkyl sulfate. It has been found that an oral composition can be provided.

That is, the non-aqueous oral composition of the present invention is a non-aqueous oral composition containing hydroxypropyl cellulose and is selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol. The content of at least one specific non-aqueous solvent (the total content of these solvents when the group contains a plurality of solvents) is 30% by mass or more and 85% by mass or less. The content of the loylalkyltaurine salt-type anionic surfactant is 0.1% by mass or more and 10% by mass or less, and the content of the alkylamide propyl betaine-type amphoteric surfactant is 0.1% by mass or more and 10% by mass or less. It is characterized by being.

With such a configuration, the excellent effect as described above can be obtained. In particular, while suppressing stability during high-temperature storage and irritation to the oral mucosa and toothpaste, the amount of foam (foaming amount) generated when using a non-aqueous oral composition is moderately increased, and the foam persistence. Excellent foam dripping is less likely to occur, foam quality (foam elasticity, fine texture, etc.) is improved, and the usability of the non-aqueous oral composition is excellent.

On the other hand, if these conditions are not met, satisfactory results cannot be obtained.
For example, if hydroxypropyl cellulose is not contained, the stability of the non-aqueous oral composition at high temperature storage is lowered, and solid-liquid separation and hardening are likely to occur. In addition, the sustainability of the foam generated during use is reduced and foam dripping is likely to occur, and the foam quality (elasticity of the foam, fineness of texture, etc.) is reduced, and the use of a non-aqueous oral composition The feeling is significantly reduced, or it is not established as a non-aqueous oral composition in the first place.

In addition, when the above-mentioned specific non-aqueous solvent is not contained, or when the content is less than the lower limit even if it is contained, the solid content (including the dissolved one) contained in the non-aqueous oral composition is determined. It becomes difficult to mix favorably, and the usability of the non-aqueous oral composition is significantly reduced.

When the sum of the contents of the above-mentioned specific non-aqueous solvent exceeds the upper limit, the content of other components is relatively reduced, and the foaming power (foaming when the non-aqueous oral composition is used). Problems such as a significant decrease in the amount, the durability of the foam (difficulty of dripping), the elasticity of the foam, the quality of the foam such as the fineness of the texture, etc. occur. Further, when the solvent is replaced with another non-aqueous solvent, problems such as a significant decrease in foaming power and usability occur.

Further, when the alkiloylalkyltaurine salt-type anionic surfactant is not contained or when the content is less than the above lower limit even if it is contained, it is assumed that the other foaming agent is contained at a relatively high content. However, sufficient foaming power (amount of foaming when using a non-aqueous oral composition, foam durability (difficulty of foam dripping), foam elasticity, foam quality such as fine texture, etc.) is obtained. I can't.

Further, when the content of the alkiloyl alkyl taurine salt-type anionic surfactant exceeds the above upper limit value, as in the case where the content is too small, sufficient foaming power (when using a non-aqueous oral composition) The amount of foam, the durability of the foam (difficulty of dripping), the elasticity of the foam, the quality of the foam such as the fineness of the texture, etc.) cannot be obtained.

Further, when the alkylamide propyl betaine type amphoteric tenside is not contained or when the content is less than the above lower limit even if it is contained, even if another foaming agent is contained at a relatively high content. Sufficient foaming power (amount of foaming when using non-aqueous oral composition, foam durability (difficulty of foam dripping), foam elasticity, foam quality such as fine texture, etc.) cannot be obtained. ..

Further, when the content of the alkylamide propyl betaine type amphoteric tenside exceeds the above upper limit value, sufficient foaming power (when using a non-aqueous oral composition) is sufficient as in the case where the content is too small. The amount of foam, the durability of the foam (difficulty of dripping), the elasticity of the foam, the quality of the foam such as the fineness of the texture, etc.) cannot be obtained.

Sufficient foaming power (non-sufficient foaming power) is also obtained when at least one of the alkiloyl alkyl taurine salt-type anionic surfactant and the alkylamide propyl betaine-type amphoteric surfactant is replaced with another surfactant instead. It is not possible to obtain the amount of foaming, the durability of foam (difficulty of foam dripping), the elasticity of foam, the quality of foam such as fine texture, etc. when using an aqueous oral composition.

In the present specification, the oral composition refers to dentifrices such as dentifrices, liquid dentifrices, and dentifrices, creams, ointments, patches, mouthwashes, mouthwashes, and the like. It refers to a composition applied to the oral cavity such as chewing gum.

Further, in the present specification, the non-aqueous oral composition means that the content of water with respect to the entire oral composition is 0% by mass or more and 3% by mass or less, preferably 0% by mass or more and 1% by mass or less. , More preferably, it means an oral composition containing substantially no water (water content is 100 ppm or less).

<Hydroxypropyl cellulose>
As described above, the non-aqueous oral composition of the present invention contains hydroxypropyl cellulose.

Hydroxypropyl cellulose is a nonionic cellulose ether obtained by reacting cellulose with propylene oxide. There are grades that develop various viscosities depending on the degree of molecular polymerization. Low-viscosity grades have a viscosity of 1 mPa · s or more and 4 mPa · s or less, and high-viscosity grades have a viscosity of 1000 mPa · s or more and 5000 mPa · s or less. This viscosity is a value (mPa · s) measured using a rotational viscometer for each 2% by mass aqueous solution of hydroxypropyl cellulose.

The hydroxypropyl cellulose constituting the non-aqueous oral composition of the present invention preferably has a viscosity obtained as described above in the range of 150 mPa · s or more and 4000 mPa · s or less.

In the non-aqueous oral composition, hydroxypropyl cellulose has a function of ensuring the properties and shape of the composition, improving the sustainability of bubbles generated during use, and making it difficult for foam to drip.

The content of hydroxypropyl cellulose in the non-aqueous oral composition is not particularly limited, but is preferably 0.1% by mass or more and 5.0% by mass or less, and 0.3% by mass or more and 3.0% by mass or less. It is more preferably 0.5% by mass or more and 2.0% by mass or less.

As a result, the effect of containing hydroxypropyl cellulose as described above is more prominently exhibited.

<Specific non-aqueous solvent>

As described above, the non-aqueous oral composition of the present invention contains a specific non-aqueous solvent (at least one selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol). Includes.

In the non-aqueous oral composition, the specific non-aqueous solvent preferably mixes the solid content in the non-aqueous oral composition to prevent the occurrence of non-uniform variation and increase the viscosity of the non-aqueous oral composition. It exerts a function of suitable adjustment and contributes to improvement of usability of non-aqueous oral composition.

The content of the specific non-aqueous solvent in the non-aqueous oral composition may be 30% by mass or more and 85% by mass or less, preferably 40% by mass or more and 80% by mass or less, and 50% by mass or more and 75% by mass. It is more preferably 60% by mass or less, and further preferably 60% by mass or more and 70% by mass or less.
As a result, the above-mentioned effect is more prominently exhibited.

The specific non-aqueous solvent constituting the non-aqueous oral composition of the present invention may be at least one selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol. In particular, the non-aqueous oral composition of the present invention preferably contains propylene glycol.

<Alkiloyl alkyl taurine salt-type anionic surfactant>
As described above, the non-aqueous oral composition of the present invention contains an alkylylalkyltaurine salt-type anionic surfactant.

In the non-aqueous oral composition, the alkyroyl alkyl taurine salt type anionic surfactant has a function of improving the amount of foaming when the non-aqueous oral composition is used, and in particular, the alkylamide propyl betaine type. By being contained together with an amphoteric surfactant under the condition of a predetermined content, foaming power (foaming amount when using a non-aqueous oral composition, foam durability (difficulty of foam dripping), foam elasticity). It has a function to improve the quality of foam such as sex and fineness of texture.

The content of the alkiloyl alkyl taurine salt-type anionic surfactant in the non-aqueous oral composition may be 0.1% by mass or more and 10% by mass or less, but is 0.3% by mass or more and 3.0% by mass or less. % Or less, more preferably 0.4% by mass or more and 2.0% by mass or less, and further preferably 0.5% by mass or more and 1.5% by mass or less.
As a result, the above-mentioned effect is more prominently exhibited.

Examples of the alkiloyl alkyl taurine salt-type anionic surfactant include coconut oil fatty acid methyl taurine sodium (Nikko Chemicals), lauroyl methyl taurine sodium (Nikko Chemicals), myristyl methyl taurine sodium (Nikko Chemicals), and palmitoyl methyl taurine sodium (Nikko Chemicals). Nikko Chemicals), N-stearoyl-N-methyltaurine sodium (Nikko Chemicals) and the like, but among them, lauroylmethyltaurine sodium is preferable.

As a result, the above-mentioned effect is more prominently exhibited.

<Alkylamide propyl betaine type amphoteric tenside>
As described above, the non-aqueous oral composition of the present invention contains an alkylamide propyl betaine type amphoteric tenside agent.

In the non-aqueous oral composition, the alkylamide propyl betaine type amphoteric surfactant has a function of improving the amount of foaming when the non-aqueous oral composition is used, and in particular, the alkiloyl alkyl taurine salt type shade. By being contained together with an ionic surfactant under the condition of a predetermined content, foaming power (foaming amount when using a non-aqueous oral composition, foam durability (difficulty of foam dripping), foam elasticity). It has a function to improve the quality of foam such as sex and fineness of texture.

The content of the alkylamide propyl betaine type amphoteric tenside agent in the non-aqueous oral composition may be 0.1% by mass or more and 10% by mass or less, but 0.3% by mass or more and 3.0% by mass or less. It is more preferably 0.4% by mass or more and 2.0% by mass or less, and further preferably 0.5% by mass or more and 1.5% by mass or less.
As a result, the above-mentioned effect is more prominently exhibited.

Examples of the alkylamide propyl betaine type amphoteric tenside agent include lauric acid amide propyl betaine (Nichiyu), cocamidopropyl betaine (Goldschmidt AG), palm kernel oil fatty acid amide propyl betaine (Nichiyu), and cocamidopropyl hydroxysul. Tine and the like can be mentioned, but among them, cocamidopropyl betaine is preferable.

As a result, the above-mentioned effect is more prominently exhibited.

When the content of the alkyloylalkyltaurine salt-type anionic surfactant in the non-aqueous oral composition is X1 [mass%] and the content of the alkylamide propyl betaine-type amphoteric surfactant is X2 [mass%]. , 0.1 ≦ X1 / X2 ≦ 10 is preferably satisfied, 0.2 ≦ X1 / X2 ≦ 5.0 is more preferably satisfied, and 0.4 ≦ X1 / X2 ≦ 3. It is more preferable to satisfy the relationship of 0.

As a result, the amount of foam generated when the non-aqueous oral composition is used, the durability of the foam, and the foam quality are particularly excellent, and the usability of the non-aqueous oral composition is further improved.

The sum (X1 + X2) of the content of the alkyloylalkyltaurine salt-type anionic surfactant and the content of the alkylamide propylbetaine-type amphoteric tenside in the non-aqueous oral composition is 0.6% by mass or more. It is preferably 6.0% by mass or less, more preferably 0.8% by mass or more and 4.0% by mass or less, and further preferably 1.0% by mass or more and 3.0% by mass or less.

As a result, the amount of foam generated when the non-aqueous oral composition is used, the durability of the foam, and the foam quality are particularly excellent, and the usability of the non-aqueous oral composition is further improved.

<Xanthan gum>
The non-aqueous oral composition of the present invention may contain xanthan gum.

As a result, a synergistic effect is exhibited when used in combination with the above-mentioned components, and the sustainability and foam quality of the foam generated when the non-aqueous oral composition is used are further improved, and the non-aqueous oral composition is further improved. Usability is further improved.

The content of xanthan gum in the non-aqueous oral composition is preferably 0.1% by mass or more and 5.0% by mass or less, and more preferably 0.3% by mass or more and 3.0% by mass or less. , 0.5% by mass or more and 2.0% by mass or less is more preferable.
As a result, the above-mentioned effect is more prominently exhibited.

<Hypromellose methylcellulose>
The non-aqueous oral composition of the present invention may contain hydroxypropylmethyl cellulose.

As a result, a synergistic effect is exhibited when used in combination with the above-mentioned components, and the sustainability and foam quality of the foam generated when the non-aqueous oral composition is used are further improved, and the non-aqueous oral composition is further improved. Usability is further improved.

The content of hydroxypropylmethylcellulose in the non-aqueous oral composition is preferably 0.1% by mass or more and 5.0% by mass or less, and preferably 0.3% by mass or more and 3.0% by mass or less. More preferably, it is 0.5% by mass or more and 2.0% by mass or less.
As a result, the above-mentioned effect is more prominently exhibited.

<Ingredients that are easily denatured by water>
The non-aqueous oral composition of the present invention may contain a component that is easily denatured by water.
As a result, the effect of making the oral composition non-aqueous is more remarkable.

Ingredients that are easily denatured by water include, for example, α-tertiary calcium phosphate (α-TCP), fluoride, enzymes, antibacterial agents such as hinokithiol and triclosan, and antibacterial agents such as sodium copper chlorophyllin, lysozyme chloride and ε-aminocaproic acid. Examples thereof include inflammatory agents, vitamin preparations such as ascorbic acid and salts thereof, crude drugs, lysozymes and the like, and one or more selected from these groups can be used.

α-Tricalcium phosphate (α-TCP) has an extremely high effect of promoting remineralization in the oral cavity, and is particularly effective in preventing and repairing dental caries. On the other hand, α-TCP has the property of converting to an apatite compound in the presence of water, and the reaction is accelerated in the presence of fluoride or other calcium phosphate, causing a self-curing reaction, and thus contains normal water. It was not possible to make a stable formulation in the oral composition such as the dentifrice.

Examples of the fluoride include sodium fluoride, potassium fluoride, sodium monofluorophosphate, tin fluoride and the like.

Examples of the enzyme include lysozyme, mutanase, protease, amylase, dextranase and the like having a lytic action and a proteolytic action. These enzymes have the property of being easily hydrolyzed in water-containing oral compositions.

Hinokitiol is a compound known as a natural bactericidal agent having a strong antibacterial activity and a broad antibacterial spectrum, and ε-aminocaproic acid is a compound having an antiplasmin effect, a hemostatic effect, and an anti-inflammatory effect. These compounds (active ingredients) also have the property of being easily hydrolyzed in the oral composition containing water.

Ascorbic acid and its salts are known to be effective in preventing gingival inflammation, alveolar pyorrhea, etc. in addition to functioning as an antioxidant, but the decomposition reaction easily proceeds in the presence of water, and the content Causes deterioration and discoloration.

Examples of the salt of ascorbic acid include sodium ascorbic acid, potassium ascorbic acid, calcium ascorbic acid, magnesium ascorbic acid and the like.

<Other ingredients>
The non-aqueous oral composition of the present invention may contain components other than the above.

Examples of such components (other components) include abrasives, moisturizers other than the above, solvents, binders other than the above, fragrances, cleaning agents, sweeteners, pH adjusters, preservatives, and solubilizers. , Foaming agents, lubricants, oils, colorants, chelating agents, moisturizers, antibacterial agents, anti-inflammatory agents, vitamin agents, crude drugs and the like other than the above.

Examples of the cleaning agent include silica-based abrasives such as silica gel, precipitated silica, hydrous silicic acid, silicic anhydride, aluminosilicate and zirconosilicate; calcium dihydrate dihydrate, calcium dihydrate anhydride and the like. Calcium hydrogen phosphate for toothpaste; calcium carbonate such as light calcium carbonate and heavy calcium carbonate; calcium phosphate, dicalcium phosphate, magnesium tertiary phosphate, insoluble sodium metaphosphate, calcium pyrophosphate, aluminum hydroxide, aluminum oxide, magnesium carbonate, Examples thereof include zirconium silicate, titanium dioxide, synthetic resin-based abrasives, alumina, zeolite and the like, and one or a combination of two or more selected from these can be used.

Examples of the wetting agent other than the above include one or more selected from saccharides such as sorbitol, ethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, erythritol, mannitol, palatinose, trehalose and other rare sugars. Can be used in combination.

Examples of the solvent include ethanol, propyl alcohol, isopropyl alcohol and the like.

Examples of binders other than the above include carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose and the like and salts and derivatives thereof; gums such as alginic acid and its salts and its derivatives and carrageenan; synthesis of polyvinyl alcohol, sodium polyacrylate and the like. Examples thereof include a binder, and one or a combination of two or more selected from these can be used.

Fragrances include, for example, l-menthol, l-carboxylic, synamic aldehyde, orange oil, anetol, 1,8-cineole, methylsalicylate, eugenol, timol, linalol, limonene, menton, mentylacetate, citral, camphor, borneol. , Peppermint, spirantol, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methylanthranilate, ethylmethylphenylglycidate, benzaldehyde, vanillin, ethyl vanillin, flaneol, maltol, ethyl maltol, gamma / delta decalactone, Fragrance components such as gamma / deltown decalactone, N-ethyl-p-menthan-3-carboxamide, menthyl lactate, ethylene glycol-l-mentyl carbonate; peppermint oil, spearmint oil, eucalyptus oil, clove oil, thyme oil, sage Natural essential oils such as oil, cardamon oil, rosemary oil, majorum oil, lemon oil, nutmeg oil, lavender oil, paracress oil; known fragrances such as blended flavors of apple, strawberry, blueberry, peach, grape, wine, yogurt, etc. Materials and the like can be mentioned, and one or a combination of two or more selected from these can be used.

Examples of the sweetener include aspartame, sodium saccharin, acesulfame potassium, stevia and the like, and one or a combination of two or more selected from these can be used.

Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, or these chemically available salts such as disodium hydrogen phosphate, sodium hydroxide, and the like, and the pH of the composition is appropriate. One or a combination of two or more selected from these can be used so as to be in the range.

Examples of the preservative include paraoxybenzoic acid esters, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like, and one selected from these. Two or more types can be used in combination.

Examples of the solubilizer include sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene hydrogenated Himashi. Examples thereof include oils and soybean phospholipids, and one or a combination of two or more selected from these can be used.

Examples of foaming agents other than the above include N-acylamino acid salts such as sodium lauroyl sarcosin, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerin sulfonate, sodium α-olefin sulfonate, N-acylglutamate, and 2-alkyl. -N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, multitoll fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, poly Examples thereof include oxyethylene fatty acid esters, and one or a combination of two or more selected from these can be used. The non-aqueous oral composition of the present invention does not exclude the inclusion of a small amount (for example, 0.1% by mass or less) of sodium lauryl sulfate, but does not contain sodium lauryl sulfate. preferable.

Examples of the lubricant include magnesium stearate, sucrose fatty acid ester, talc, hydrogenated oil, and the like, and one or a combination of two or more selected from these can be used.

Examples of the oil include coconut oil, olive oil, sesame oil, peanut oil, parsley oil, parsley seed oil, safflower oil and the like, and one or a combination of two or more selected from these can be used.

Examples of the colorant include tar pigments such as Blue No. 1, pigments such as titanium dioxide, and various dyes, and one or a combination of two or more selected from these can be used.

Moisturizers include, for example, amino acids or salts thereof, pyrrolidonecarboxylic acid, mutin, hyaluronic acid or salts thereof, mucopolysaccharides such as chondroitin sulfate, sodium lactate, urea, pantenol, aloe extract, rosemary extract, thyme extract, etc. Examples include natural extract components such as cha extract (cha dry distillate extract), so-called extracellular matrix such as collagen and elastin, and one or a combination of two or more selected from these can be used.

Examples of the antibacterial agent include phenolic antibacterial agents such as isopropylmethylphenol, triclosan, and timol; cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, decalinium chloride, chlorhexidine hydrochloride, sodium chlorhexidine gluconate, bisabolol chlorhexidine, and the like. Examples thereof include lactoferrin, and one or a combination of two or more selected from these can be used.

Examples of the anti-inflammatory agent include lysozyme chloride, ε-aminocaproic acid, aluminum hydroxyl allantoin, glycyrrhetinic acid, glycyrrhizates, guaiazulene sulfonic acid, dl-α-tocopherol acetate and the like, and are selected from these 1 Species or a combination of two or more can be used.

Examples of vitamin preparations include vitamin A such as retinoic acid and β-carotene, pantothenic acid or salts thereof, vitamin B such as niacin and biotin, vitamin E such as α-tocopherol, and folic acid. One type or a combination of two or more types selected from the above can be used.

Herbal medicines include, for example, Ogon, Kikyo, Jio, Chamomile, Valeriana, Jujube, Hop, Ramender, Linden, Karin, Kinginka, Kumazasa, Gummy, Clove, Denshichininjin, Salvia, Mukuroji, Keihi, Bukuryo, Shakuyaku, Hawthorn, Touki, Examples include chamomile, hawthorn, hawthorn, valeriana, carrot, jujube, turmeric, rosemary and the like, and one or a combination of two or more selected from these can be used.

When the oral composition contains the above-mentioned crude drug, the oral composition may contain the above-mentioned crude drug as it is, for example, by crushing a dried plant or water. It may be contained as a component (extract) obtained by removing the extraction medium from the extract or the extract extracted by using an extraction solvent such as an organic solvent or an extraction medium such as a supercritical fluid.

Although preferred embodiments of the present invention have been described above, the present invention is not limited to the above.

The present invention will be described in more detail with reference to specific examples below, but the present invention is not limited to these examples.

<< 1 >> Production of Non-Aqueous Oral Composition The non-aqueous oral composition according to each Example and each Comparative Example was produced as follows.

(Example 1)
First, at room temperature (23 ° C.), hydroxypropyl cellulose, propylene glycol as a specific non-aqueous solvent, lauroylmethyl taurine sodium as an alkylylalkyltaurine salt-type anionic surfactant, and alkylamide propylbetaine-type amphoteric surfactant. Cocamidopropyl betaine, xanthan gum, hydroxypropyl methyl cellulose, calcium phosphate, silicic anhydride, and glycerin fatty acid ester were mixed in a predetermined ratio to prepare a base for a non-aqueous oral composition.

Then, at room temperature (23 ° C.), the base for the non-aqueous oral composition and ascorbic acid are mixed in a predetermined ratio, and toothpaste as a non-aqueous oral composition having the composition shown in Table 1 is used. I got the agent.

(Examples 2 to 19)
Other than the compositions shown in Tables 1 and 2 by adjusting the types and proportions of the components used in the production of non-aqueous oral compositions bases and non-aqueous oral compositions (dentifrices). Produced a dentifrice as a non-aqueous oral composition in the same manner as in Example 1.

(Comparative Examples 1 to 15)
Except that the composition shown in Table 2 was obtained by adjusting the types and proportions of the components used in the production of the non-aqueous oral composition base and the non-aqueous oral composition (dentifrice). A dentifrice as a non-aqueous oral composition was produced in the same manner as in Example 1.

The compositions of the non-aqueous oral compositions according to each of the above-mentioned Examples and Comparative Examples are summarized in Tables 1 and 2. In Tables 1 and 2, the unit of the content of each component is mass%. Further, in the non-aqueous oral composition (dentifrice) of each of the above Examples and Comparative Examples, the water content was 100 ppm or less.

<< 2 >> Evaluation We asked 10 adults to put about 1 g of the non-aqueous oral composition according to each of the above Examples and Comparative Examples on a commercially available toothbrush and brush it for 1 minute, and evaluated the following items. I got it.

<< 2-1 >> Difficulty of foam dripping Regarding the difficulty of foam dripping outside the oral cavity during 1 minute of brushing for each subject, if it is difficult to foam dripping: 2 points, foam dripping When it is difficult to evaluate whether it is easy or difficult: 1 point, when foaming is easy: 0 points are scored, and the average value of the points of 10 subjects was calculated and evaluated according to the following criteria.

A: The average value of points is 1.8 points or more.
B: The average value of points is 1.4 points or more and less than 1.8 points.
C: The average value of points is 1.0 points or more and less than 1.4 points.
D: The average value of points is 0.6 points or more and less than 1.0 points.
E: The average value of points is less than 0.6 points.

<< 2-2 >> Foaming amount After brushing for 1 minute, the foam in the oral cavity was discharged into a test tube, and immediately after that, the foam amount was measured, and the average value for 10 people was calculated and evaluated according to the following criteria.

A: The average value of the amount of foam is 20 mL or more.
B: The average value of the amount of foam is 17 mL or more and less than 20 mL.
C: The average value of the amount of foam is 14 mL or more and less than 17 mL.
D: The average value of the amount of foam is 11 mL or more and less than 14 mL.
E: The average amount of foam is less than 11 mL.

<< 2-3 >> Foam quality evaluation << 2-3-1 >> Foam elasticity When each subject feels excellent elasticity of the foam in the oral cavity during brushing: 2 points, medium elasticity If you feel sex: 1 point, if you feel that elasticity is inferior: 0 points were scored, and the average value of the points of 10 subjects was calculated and evaluated according to the following criteria.

A: The average value of points is 1.8 points or more.
B: The average value of points is 1.4 points or more and less than 1.8 points.
C: The average value of points is 1.0 points or more and less than 1.4 points.
D: The average value of points is 0.6 points or more and less than 1.0 points.
E: The average value of points is less than 0.6 points.

<< 2-3-2 >> Fine texture of foam When each subject feels that the fineness of texture (creaminess) of the foam in the oral cavity during brushing is excellent: 2 points, medium If you feel the fineness of the texture: 1 point, if you feel that the texture is inferior: 0 points, calculate the average value of the points of 10 subjects, and follow the following criteria evaluated.

A: The average value of points is 1.8 points or more.
B: The average value of points is 1.4 points or more and less than 1.8 points.
C: The average value of points is 1.0 points or more and less than 1.4 points.
D: The average value of points is 0.6 points or more and less than 1.0 points.
E: The average value of points is less than 0.6 points.

<< 2-4 >> Irritation Regarding the irritation to the oral mucosa and gums during brushing, each subject felt weak irritation: 2 points, moderate irritation: 1 point, irritation If you feel strong: Have them score 0 points, calculate the average value of the points of 10 subjects, and evaluate according to the following criteria.

A: The average value of points is 1.8 points or more.
B: The average value of points is 1.4 points or more and less than 1.8 points.
C: The average value of points is 1.0 points or more and less than 1.4 points.
D: The average value of points is 0.6 points or more and less than 1.0 points.
E: The average value of points is less than 0.6 points.

<< 2-5 >> Stability The non-aqueous oral compositions according to each of the Examples and Comparative Examples were stored in an incubator at 60 ° C. for 3 weeks, respectively, and their properties were judged according to the following criteria.

A: No hardening or solid-liquid separation was observed, and it was stable.
B: Slight hardening tendency and solid-liquid separation tendency are observed, but it is stable.
C: Hardening and solid-liquid separation were observed.
These results are shown in Table 3.

As is clear from Table 3, excellent results were obtained in the present invention, whereas satisfactory results were not obtained in the comparative examples.

Further, except that α-tricalcium phosphate (α-TCP), sodium fluoride, lysozyme, hinokitiol, and ε-aminocaproic acid were used instead of ascorbic acid, they were not used in the same manner as in each of the above Examples and Comparative Examples. When a dentifrice as an aqueous oral composition was produced and evaluated in the same manner as described above, the same results as described above were obtained.

The non-aqueous oral composition of the present invention is a non-aqueous oral composition containing hydroxypropyl cellulose and is selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol. When the content of at least one specific non-aqueous solvent is 30% by mass or more and 85% by mass or less, and the content of the alkiloylalkyltaurine salt-type anionic surfactant is 0.1% by mass or more and 10% by mass or less. It is characterized in that the content of the alkylamide propyl betaine type amphoteric surfactant is 0.1% by mass or more and 10% by mass or less. Therefore, the affinity between the non-aqueous solvent and hydroxypropyl cellulose is enhanced during high-temperature storage, solid-liquid separation and hardening are unlikely to occur, the foaming power is high, and the non-aqueous oral composition is less irritating to the oral mucosa and toothpaste. Can provide things. Therefore, the non-aqueous oral composition of the present invention has industrial applicability.

Claims (6)

A non-aqueous oral composition containing hydroxypropyl cellulose.
The content of the specific non-aqueous solvent, which is at least one selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol, is 30% by mass or more and 85% by mass or less.
The content of the alkiloyl alkyl taurine salt-type anionic surfactant is 0.1% by mass or more and 10% by mass or less.
A non-aqueous oral composition comprising an alkylamide propyl betaine type amphoteric tenside having a content of 0.1% by mass or more and 10% by mass or less. The non-aqueous oral composition according to claim 1, wherein the alkiloylalkyltaurine salt-type anionic surfactant is sodium lauroylmethyltaurine. The non-aqueous oral composition according to claim 1 or 2, wherein the alkylamide propyl betaine type amphoteric surfactant is cocamidopropyl betaine. 0.1 ≤ X1 when the content of the alkylamide alkyltaurine salt-type anionic surfactant is X1 [mass%] and the content of the alkylamide propyl betaine-type amphoteric surfactant is X2 [mass%]. The non-aqueous oral composition according to any one of claims 1 to 3, which satisfies the relationship of / X2 ≦ 10. The non-aqueous oral composition according to any one of claims 1 to 4, further comprising xanthan gum in a content of 0.1% by mass or more and 5.0% by mass or less. The non-aqueous oral composition according to any one of claims 1 to 5, further comprising hydroxypropylmethyl cellulose in a content of 0.1% by mass or more and 5.0% by mass or less.