WO2022102628A1

WO2022102628A1 - Composition for oral cavity

Info

Publication number: WO2022102628A1
Application number: PCT/JP2021/041226
Authority: WO
Inventors: 弘子工藤; 麻衣小幡
Original assignee: ライオン株式会社
Priority date: 2020-11-10
Filing date: 2021-11-09
Publication date: 2022-05-19
Also published as: JP2022076813A; CN116744890A

Abstract

Provided is a nonaqueous composition for the oral cavity that makes it possible to obtain a favorable moisturized feeling and suppresses a feeling of powder abrasion, and that has properties such as good shape retention and spinnability. This composition for the oral cavity: contains (A) an inorganic powder body and (B) a cooling agent; has a surfactant content of 0.5 mass% or less; and has a water content of 2 mass% or less.

Description

Oral composition

The present invention relates to an oral composition.

A non-aqueous oral composition that does not contain substantially water is advantageous in that the stability of the active ingredient, which is unstable in the aqueous system, can be ensured. For example, a non-aqueous oral composition used for an oral application such as a dentifrice, an oral moisturizing gel, or an oral cream, which does not substantially contain water, is particularly resistant to water. It is advantageous in that it can be effectively blended while ensuring the stability of the unstable component.

For example, Patent Document 1 below describes a composition used for whitening teeth, which adheres to the tooth surface at the time of application, remains on the tooth surface after removal of the application tool, and is an oral cavity at the time of application. For the purpose of achieving both suppression of leakage of the composition to the whole and dispersibility during brushing, (A) glycerin and 1,3-butylene glycol as tooth whitening components, (B) zeolite having a predetermined structure, (C). Xanthan gum, carboxymethyl cellulose and salts thereof, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxyvinyl polymer, carrageenan, at least one gelling agent selected from methyl vinyl ether / maleic anhydride copolymer crosslinked by a cross-linking agent, and ( D) Non-aqueous compositions containing alkyl sulfates are disclosed.

Further, Patent Document 2 below provides a non-aqueous oral composition containing no water or almost no water, which has excellent shape retention and is stable over time without separation of components. A base for an oral composition, which comprises at least one selected from the group consisting of polyethylene powder and polyethylene wax, and at least one selected from the group consisting of liquid paraffin, squalane and squalane. Is disclosed.

Japanese Patent No. 4462428 Japanese Patent No. 472608

However, according to the non-aqueous oral composition disclosed in the above patent document, it may be difficult to obtain a moisturizing feeling in the oral cavity after use, and a surfactant, particularly an anionic surfactant, is used in particular. If this is the case, the user may experience a strong feeling of degreasing after use, and as a result, the feeling of moisturizing in the oral cavity may be significantly reduced, resulting in a feeling of dryness.

In addition, in many cases, non-aqueous oral compositions, including the oral compositions according to the above patent documents, are inorganic powders for the purpose of imparting polishing ability, caking ability, and suppressing spinnability. The body is compounded.

However, in a non-aqueous oral composition containing an inorganic powder, if the amount of the above-mentioned surfactant is reduced in order to enhance the moisturizing feeling, it is used due to the inorganic powder, especially in the initial stage of use. A person may feel a strong squeaky feeling.

Therefore, an object of the present invention is to provide a non-aqueous oral composition capable of obtaining a good moisturizing sensation, suppressing a powdery squeaky sensation, and having good properties such as shape retention and spinnability. To do.

That is, the present invention provides the following [1] to [7].
[1] Contains (A) inorganic powder and (B) cooling sensitizer.
The content of the surfactant is 0.5% by mass or less,
An oral composition having a water content of 2% by mass or less.
[2] (B) The cooling sensitizer is N-ethyl-p-menthane-3-carboxamide, mentyllactate, mentylmonosuccinate, isopregol, mentonglycerol ketal, N- (4-cyanomethylphenyl) -p-menthane. Carboxamide, 3-l-mentoxypropane-1,2-diol, 5-methyl-2-propane-2-yl-N- (2-pyridine-2-ylethyl) cyclohexane-1-carboxamide, 3- (p-) Mentan-3-Carboxamide) The oral composition according to [1], which is at least one selected from the group consisting of ethyl acetate, 2-isopropyl-N, and 2,3-trimethylbutylamide.
[3] The oral composition according to [1] or [2], wherein the content of the inorganic powder (A) is 2 to 50% by mass.
[4] The oral composition according to any one of [1] to [3], wherein the content of the cooling sensation agent is 0.0001 to 0.3% by mass.
[5] The oral composition according to any one of [1] to [4], further comprising (C) glycyrrhizic acid, and one or more selected from the group consisting of glycyrrhizic acid and salts thereof.
[6] The oral composition according to any one of [1] to [5], further comprising (D) a solvent, wherein the solvent is a polyhydric alcohol having a melting point of 25 ° C. or lower.
[7] The oral composition according to any one of [1] to [6], which is a dentifrice or a coating agent.

According to the present invention, there is provided a non-aqueous oral composition capable of obtaining a good moisturizing sensation, suppressing a powdery squeaky sensation, and having good properties such as shape retention and spinnability. Can be done.

Hereinafter, the present invention will be described in detail.
The oral composition of the present invention contains (A) an inorganic powder and (B) a cooling sensation agent, and has a surfactant content of 0.5% by mass or less and a water content of 2% by mass or less. A certain oral composition, which may further contain (C) glycyrrhetinic acid, and one or more selected from the group consisting of glycyrrhetinic acid and salts thereof, and / or (D) a solvent.

Here, in the present specification, the "moisturizing sensation" means a sensation that the user (tester) feels that the tongue and the oral mucosa are moisturized at the time of use.
Further, in the present specification, the "powder squeaky feeling" means a feeling of discomfort or a foreign body sensation that is felt especially when the upper and lower teeth come into contact with each other at the initial stage of use (beginning of polishing) due to the local presence of the inorganic powder. To say.
Further, as used herein, the term "threading property" refers to a property in which the oral composition stretches like a string when it is taken out from a container such as a laminated tube.

Hereinafter, the components (A) to (D) that can be contained in the oral composition will be described.

[(A) Inorganic powder]
The "component (A)" according to the embodiment of the present invention is an inorganic powder. The component (A) is a component generally used as an abrasive, an inorganic thickener, an inorganic pigment, or the like in an oral composition.

Examples of the inorganic powder include silica compounds such as silicic anhydride, precipitated silica, titanium-binding silica, silica gel, aluminosilicate, and zirconosilicate; calcium carbonate (light and heavy), calcium phosphate, calcium hydrogen phosphate, and the like. Calcium salts such as calcium pyrophosphate, calcium metaphosphate, calcium hydroxide, calcium sulfate; aluminum salts such as aluminum oxide, aluminum hydroxide, and alumina; magnesium salts such as magnesium carbonate and tertiary magnesium phosphate; hydroxyapatite, fluoroapatite, calcium Examples thereof include apatites such as defective apatites; clay minerals such as kaolinite and bentonite; titanium compounds such as titanium dioxide, mica titanium and titanium oxide; and powders of inorganic substances such as titanium oxide. Of these, anhydrous silicic acid, calcium carbonate, aluminum oxide, aluminum hydroxide, and zeolite are more preferable.

The average particle size (volume standard D50) of the inorganic powder is usually in the range of 1 to 30 μm, preferably in the range of 5 to 25 μm.

In the present specification, the "average particle size" means the average particle size (volume standard D50) which is a measured value by the laser diffraction / scattering method as described above.

For the average particle size, for example, a conventionally known arbitrary suitable particle size distribution measuring device (for example, Microtrack particle size distribution measuring device (Made 117995-10, Type SRA) manufactured by Nikkiso Co., Ltd.) is used, and the turbidity (dV value) of the sample is used. Can be adjusted to 0.5 for measurement. The same measurement was performed in the examples described later.

As the component (A), one selected from the above-exemplified inorganic powders may be used alone, or two or more thereof may be used in combination. As a combination of two or more, for example, an inorganic powder that can be used in an abrasive application (for example, RDA 50 to 120, preferably 70 to 150, more preferably 90 to 120) and an inorganic thickener are used. Examples thereof include a combination with the obtained inorganic powder (for example, liquid absorption amount of 2 to 5 mL / g, preferably 2.5 to 5 mL / g). The liquid absorption amount can be calculated as, for example, the following measurement method as the liquid absorption amount (mL) per 1 g of thickened silica.

Weigh 1.0 g of the sample on a clean glass plate, and mix the sample with a stainless steel spatula while dropping 42.5% glycerin little by little using a micro burette. The amount of liquid (mL) required until the sample becomes one lump and can be peeled off cleanly from the glass plate with a spatula is defined as the liquid absorption amount.

-Contents of (A) component-
The content of the component (A) is usually 2% by mass or more, preferably 5% by mass or more, and more preferably 8% by mass or more with respect to the total amount of the oral composition. As a result, an appropriate viscosity can be imparted, good shape retention can be ensured, and a good feeling of use can be realized. The upper limit is usually 50% by mass or less, preferably 40% by mass or less, more preferably 30% by mass or less, still more preferably 20% by mass or less. As a result, it is possible to suppress an excessive increase in the viscosity of the oral composition, maintain good shape retention, and realize a good feeling of use (feeling of cleaning). Therefore, the content of the component (A) is usually 2 to 50% by mass, preferably 5 to 50% by mass, and more preferably 8 to 40% by mass.

The viscosity of the oral composition of this embodiment is preferably about 20 to 100 Pa · s at 25 ° C. The viscosity of the oral composition is, for example, Toki Sangyo Co., Ltd. (type: VISCOMETER TVB-10), rotor No. 6 or 7 can be used, the rotation speed is 20 rpm, the measurement time is 3 minutes, and the measurement can be performed under the condition of 25 ° C.

In addition, in this specification, the content of each component is based on the amount of each component charged at the time of manufacturing an oral composition.

[(B) Cooling sensitizer]
The component (B) according to the embodiment of the present invention is a cooling sensation agent. By containing the component (B), the oral composition of the present invention can improve the powdery squeaky feeling at the initial stage of use (beginning of polishing) caused by the component (A) and realize a good feeling of use. ..

The cooling sensitizer as a component (B) is, for example, N-ethyl-p-menthan-3-carboxamide, mentyllactate, mentylmonosuccinate, isopulegol, mentonglycerol ketal, N- (4-cyanomethylphenyl) -p. -Mentancarboxamide, 3-l-mentoxypropane-1,2-diol, 5-methyl-2-propane-2-yl-N- (2-pyridine-2-ylethyl) cyclohexane-1-carboxamide, 3-( p-mentan-3-carboxamide) It is preferably at least one selected from the group consisting of ethyl acetate, 2-isopropyl-N, and 2,3-trimethylbutylamide. Of these, N-ethyl-p-menthane-3-carboxamide, N- (4-cyanomethylphenyl) -p-menthan carboxamide, 3-l-mentoxypropane-1,2-diol, 5-methyl-2 -Propane-2-yl-N- (2-pyridine-2-ylethyl) cyclohexane-1-carboxamide and 3- (p-menthan-3-carboxamide) ethyl acetate are more preferred.

-Contents of (B) component-
The content of the component (B) is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, still more preferably 0, with respect to the total amount of the oral composition, from the viewpoint of improving the powdery squeaky feeling. It is 0.01% by mass or more. As a result, it is possible to improve the powdery squeaky feeling at the initial stage of using the oral composition and realize a good feeling of use. The upper limit of the content of the component (B) is preferably 0.3% by mass or less, more preferably 0.2% by mass or less, still more preferably 0.1 from the viewpoint of optimally adjusting the viscosity of the oral composition. It is less than mass%. As a result, it is possible to improve the powdery squeaky feeling at the initial stage of using the oral composition and realize a good feeling of use. Therefore, the content of the component (B) is preferably 0.0001 to 0.3% by mass, more preferably 0.001 to 0.2% by mass, and further preferably 0.01 to 0.1% by mass. It is mass%.

[(C) Glycyrrhizic acid, and glycyrrhizic acid and its salts]
The component (C) is one or more selected from the group consisting of glycyrrhetinic acid, glycyrrhizic acid and salts thereof. By further containing the component (C) in the oral composition, it is possible to further reduce the powdery squeaky feeling at the initial stage of use and realize a good feeling of use.

The glycyrrhetinic acid may be a derivative thereof, and for example, β-glycyrrhetinic acid, stearyl glycyrrhetinate and the like can be used.

As the glycyrrhizate, for example, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate and the like can be used. Above all, it is preferable to use dipotassium glycyrrhizinate and / or β-glycyrrhetinic acid from the viewpoint of reducing the feeling of powder squeaking at the initial stage of use.

-Contents of (C) component-
The content of the component (C) is usually 0.01% by mass or more, preferably 0.03% by mass or more, based on the total amount of the oral composition. As a result, it is possible to improve the powdery squeaky feeling at the initial stage of using the oral composition and realize a good feeling of use. The upper limit is usually 0.1% by mass or less, preferably 0.05% by mass or less. As a result, it is possible to improve the powdery squeaky feeling at the initial stage of using the oral composition and realize a good feeling of use. Therefore, the content of the component (C) is usually 0.01 to 0.1% by mass, preferably 0.03 to 0.05% by mass.

[(D) Solvent]
The component (D) is a solvent. A polyhydric alcohol can be used as the component (D) which is a solvent. As the polyhydric alcohol, it is preferable to use a polyhydric alcohol having a melting point of 25 ° C. or lower.

Specific examples of the polyhydric alcohol include glycerin (melting point: 17.8 ° C.) and polyethylene glycol (PEG200) having an average molecular weight of 190 to 630 (the average molecular weight described in the Quasi-drug Raw Material Standard 2006, the same applies hereinafter). (Melting point: -35 ° C), 300 (melting point: -10 ° C), 400 (melting point: 6 ° C), 600 (melting point: 20 ° C)), propylene glycol (melting point: -20 ° C), dipropylene glycol (melting point: -20 ° C) −20 ° C.), butylene glycol (melting point: −54 ° C.), ethylene glycol (melting point: −13 ° C.), polypropylene glycol (melting point: −31 ° C.) and the like. Among these, glycerin, polyethylene glycol having an average molecular weight of 190 to 630, and butylene glycol are preferable from the viewpoint of improving the moisturizing feeling in the oral cavity. These may be used alone or in combination of two or more.

The average molecular weight of polyethylene glycol is usually 650 or less, preferably 630 or less, and more preferably 600 or less. The lower limit is usually 150 or more, preferably 250 or more. Therefore, the average molecular weight of polyethylene glycol is usually 150 to 650, preferably 150 to 630, and more preferably 250 to 600. As the polyethylene glycol, for example, polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 400 (average molecular weight 380 to 420), and polyethylene glycol 600 (average molecular weight 570 to 630) can be used. In the present specification, the average molecular weight of polyethylene glycol is the average molecular weight described in the Quasi-drug Raw Material Standard 2006.

Polyhydric alcohol has its own bitterness, but glycerin is a polyhydric alcohol with relatively little bitterness. Therefore, from the viewpoint of reducing the bitterness derived from the solvent, the solvent contains at least glycerin, and the content of glycerin is 20 to 100% by mass, particularly 50 to 85% by mass, and further 50 to 80% by mass of the total polyhydric alcohol. Is more preferable. Further, among the polyhydric alcohols, polyethylene glycol having the above average molecular weight is a preferable solvent because a good feeling of warmth can be obtained. From the viewpoint of improving the feeling of warmth, the component (D) preferably contains at least polyethylene glycol, and the content of polyethylene glycol is 10% by mass or more, particularly 15 to 30% by mass of the entire oral composition. Is more preferable. If the content of polyethylene glycol exceeds 30% by mass, the bitterness derived from polyethylene glycol may affect the usability, but if it is 30% by mass or less, a good usability can be maintained.

From the viewpoint of imparting a warm feeling to the oral composition, the polyhydric alcohol is a combination system of glycerin and polyethylene glycol having an average molecular weight of 190 to 630 and / or butylene glycol, particularly glycerin and polyethylene glycol having an average molecular weight of 190 to 630. It is preferable that the glycerin content is 50% by mass or more, particularly more preferably 50 to 85% by mass, based on the total amount of the polyhydric alcohol. That is, it is particularly preferable that the mass ratio of glycerin / (polyethylene glycol and / or butylene glycol having an average molecular weight of 190 to 630) is 50/50 to 85/15.

[Content ratio]
-(A) / (B)-
The content ratio ((A) / (B)), which is the ratio of the content of the component (A) to the content of the component (B), is preferably 67 or more, more preferably 100 or more. (A) / (B) is preferably 200,000 or less, more preferably 2000 or less. By doing so, the viscosity and shape retention of the oral composition can be improved, and the powdery squeaky feeling at the initial stage of use can be reduced. Therefore, (A) / (B) is preferably 67 to 200,000, more preferably 100 to 2000.

[amount of water]
The oral composition of the present embodiment is a non-aqueous oral composition that does not substantially contain water.
Here, "substantially water-free" means that water is not intentionally added in the manufacturing process of the oral composition.

Further, "non-aqueous" is not limited to the absence of water in the oral composition as a result in any case.

The oral composition of the present embodiment may contain water in an amount of 2% by mass or less due to, for example, water that can be inevitably mixed in the raw material. For example, even concentrated glycerin, which is a component (B) having a low water content, can inevitably contain about 0.5% by mass of water.

The water content of the oral composition of the present embodiment is usually 2% by mass or less, preferably 1% by mass or less, and more preferably 0.5% by mass or less.

The water content of the oral composition is the ratio (% by mass) of the total water content of the raw materials before compounding to the total raw materials, or the difference between the weight after drying and the weight before drying of the oral composition is dried. It can be calculated as a ratio (mass%) to the previous weight.

[Arbitrary ingredient]
The oral composition of the present embodiment may contain arbitrary components other than the components (A) to (D) already described, as long as the effects of the present invention are not impaired. Optional components include, for example, surfactants, sweeteners, fragrances, medicinal components, oily components, abrasives (organic abrasives), preservatives, wetting agents, binders, pH adjusters, colorants (pigments) and the like. Ingredients are mentioned. In the oral composition of the present embodiment, the optional components are not limited to these.

-Surfactant-
The oral composition of the present embodiment has a surfactant content of 0.5% by mass or less. That is, in the oral composition of the present embodiment, the content of the surfactant is reduced to 0.5% by mass or less, or the content of the surfactant is reduced to 0.5% by mass or less from the viewpoint of suppressing the degreasing feeling at the time of use and realizing the moisturizing feeling. It is preferable that the surfactant is not contained.

Examples of the surfactant that can be used in the oral composition include an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant.

Examples of the anionic surfactant include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. The alkyl group and the acyl group may be either a linear group or a branched chain, and may be saturated or unsaturated, and the number of carbon atoms thereof is usually 10 to 20, preferably 12 to 18, and more preferably 12 to 18. It is 14. The salt can be selected from pharmacologically acceptable salts. Pharmacologically acceptable salts include, for example, base addition salts and amino acid salts. Specific examples thereof include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt and diisopropylammonium salt; arginine salt and the like. Basic amino acid salts of. Among them, as the pharmacologically acceptable salt, an inorganic base salt is preferable, an alkali metal salt (for example, a sodium salt or a potassium salt) or an ammonium salt is more preferable, and a sodium salt is further preferable.

Examples of the alkyl sulfate include lauryl sulfate and myristoyl sulfate. Examples of the acyl amino acid salt include acyl sarcosine salts such as lauroyl sarcosin salt and myristoyl sarcosin salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate and palmitoyl glutamate; N-lauroyl-N-methylglycine salt and cocoyl glycine. Acylglycine salts such as salts; N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl Acylalanine salts such as -N-methyl-β-alanine salt, N-methyl-N-acylalanine salt; acylasparaginate such as lauroyl asparagate can be mentioned. Examples of the acyl taurine salt include lauroylmethyl taurine salt, N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of the α-olefin sulfonate include α-olefin sulfonate having 12 to 18 carbon atoms such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate.

The anionic surfactant preferably contains a sulfonic acid group in terms of foaming and good foam quality, and more preferably an alkyl sulfate or an α-olefin sulfonate. The content of the anionic surfactant is preferably 0.1 to 2.5% by mass, more preferably 0.6 to 2.5% by mass, still more preferably 1 to 2.5% by mass of the entire composition. ..

Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester (eg, polyoxyethylene sorbitan monostearate), alkylolamide, and polyoxy. Ethylene fatty acid ester, polyoxyethylene alkenyl ether, glycerin fatty acid ester, sucrose fatty acid ester (eg, maltose fatty acid ester), sugar alcohol fatty acid ester (eg, multitoll fatty acid ester, lactitol fatty acid ester), fatty acid diethanolamide (eg, lauryl) Acid mono or diethanolamide), polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, and the like. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 15 to 30 mol. The average number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is usually 20 to 100 mol, preferably 20 to 60 mol. The number of carbon atoms of the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The fatty acid of the polyoxyethylene sorbitan fatty acid ester usually has 16 to 18 carbon atoms, and the average number of moles of ethylene oxide added is usually 10 to 40 mol. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene alkyl ether are preferable.

Examples of the amphoteric surfactant include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (eg, lauryldimethylaminoacetic acid betaine) and fatty acid amide propyldimethylaminoacetic acid betaine (eg, cocamidopropyl betaine); N-. Fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt (eg, N-palm oil fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut oil fatty acid imidazolinium betaine, 2-alkyl Examples include imidazoline-type amphoteric surfactants such as -N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine. Examples of the cationic surfactant include an alkylammonium salt and an alkylbenzylammonium salt.

When the oral composition contains an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, or a combination of two or more thereof, the content is 0.5% by mass or less of the total composition. It is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, and particularly preferably 0.05% by mass or less. Above all, when an anionic surfactant is used, the content thereof is preferably 0.1% by mass or less, preferably 0.05% by mass, from the viewpoint of reducing the feeling of degreasing during use and enhancing the feeling of moisturizing. The following is more preferable, and it is further preferable to make it non-containing (0% by mass).

-Sweetener-
The oral composition of the present embodiment may contain any suitable sweetener previously known as an arbitrary suitable content. When the oral composition contains a sweetening agent, the feeling of use can be further improved.

Examples of the sweetener include xylitol, erythritol, maltitol, saccharin, saccharin sodium, aspartame, stebioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, thaumatin, aspartylphenylalanine methyl ester and the like. As the sweetener, the above-exemplified sweetener may be used alone or in combination of two or more.

-Fragrance-
The oral composition of the present embodiment may contain any suitable fragrance previously known as an arbitrary suitable content. When the oral composition contains a fragrance, the feeling of use can be further improved.

Examples of fragrances include peppermint oil, sparemint oil, eucalyptus oil, winter green oil, clove oil, thyme oil, sage oil, cardamon oil, rosemary oil, majorum oil, lemon oil, orange oil, nutmeg oil, and lavender oil. Natural essential oils such as parlacles oil, laurel oil, piment oil, laurel oil, perilla oil, winter green oil; menthol, carboxylic, synamic aldehyde, anetol, 1,8-cineole, methyl salicylate, eugenol, timole, linalol, limonen, Perfume components contained in the above natural essential oils such as menthon, mentholacetate, citral, camphor, borneol, pinen, spirantol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, ethyllinalol, varnish and the like; ethyl acetate , Ethylbutyrate, isoamylacetate, hexanal, hexenal, methylanthranilate, ethylmethylphenylglycidate, benzaldehyde, vanillin, ethylvaniline, flaneol, etc.; and a combination of several perfume ingredients and natural essential oils. Examples include various blended flavors such as mint-based, fruit-based, and herbal-based. As the fragrance, the above-exemplified fragrance may be used alone or in combination of two or more.

-Medicinal ingredient-
Examples of the medicinal ingredient include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, timole, hinokithiol, and lysodium chloride; Enzymes such as mutanase, amylase, protease, lytecenzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, tin fluoride; ε-aminocaproic acid, allantin, tranexamic acid, allantinchlorhydroxyaluminum, azulene, dihydrocholesterol, etc. Anti-inflammatory agents; Metal salts such as zinc, copper salt, tin salt; Toothstone preventive agents such as condensed phosphate and ethanehydroxydiphosphonate; , Aluminum lactate, strontium chloride and other hypersensitivity inhibitors; coating agents such as hydroxyethyl cellulose dimethyldiallyl ammonium chloride; astringents such as vitamin C (eg, ascorbic acid or salts thereof), lysozyme chloride, sodium chloride and the like; copper chlorophyll, glucon Water-soluble copper compounds such as copper acid acid; amino acids such as dentin preventive agent, alanine, glycine and proline, plant extracts such as thyme, ginger, chow and hamamelis; caropeptide and polyvinylpyrrolidone can be mentioned. The medicinal ingredient may be used alone or in combination of two or more. The content of the medicinal ingredient can be appropriately set as an effective amount according to a conventional method.

-Oil component-
Examples of the oily component include fatty acids such as squalane, liquid paraffin, vaseline, microcrystallin wax, carnauba wax, rice wax, and rosin; higher alcohols (eg, lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, iso). Alcohols with 8 to 22 carbon atoms such as stearyl alcohol); higher fatty acids (eg, fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, isostearic acid), olive oil, castor oil, coconut oil and the like. Vegetable oils; fatty acid esters such as isopropyl myristate.

-Abrasive-
The oral composition of the present embodiment may contain a conventionally known arbitrary suitable abrasive (excluding the raw material used as the component (A) already described) as an optional suitable content.

Examples of any abrasive that can be contained in the oral composition include organic abrasives such as polymethylmethacrylate and synthetic resin-based abrasives. The content of the organic abrasive is preferably 10% by mass or less (0 to 10% by mass). The total amount of the organic abrasive and the component (A) is preferably 50% by mass or less, more preferably 8 to 50% by mass, based on the whole composition.

-Preservative-
The oral composition of the present embodiment may contain any suitable preservative previously known as an arbitrary suitable content. When the oral composition contains an antiseptic, the antiseptic power of the oral composition can be ensured.

Examples of the preservative that can be contained in the oral composition include paraoxybenzoic acid esters (for example, methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate and the like. The preservative may be used alone or in combination of two or more.

-Wetting agent-
The oral composition of the present embodiment may contain any suitable wettable agent conventionally known (excluding those used as the component (D) already described) as an optional suitable content. When the oral composition contains an arbitrary wetting agent, the feeling of use can be further improved.

As the wetting agent, polyhydric alcohols other than the polyhydric alcohol exemplified as the component (D) are preferable, and examples thereof include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, and xylitol; and reduced starch saccharified products. The content of the wetting agent is usually 0 to 20% by mass, preferably 1 to 10% by mass.

-Blotting agent-
The oral composition of the present embodiment may contain any suitable binder conventionally known as an arbitrary suitable content. By including an arbitrary binder in the oral composition, the viscosity can be optimized, and the shape retention and usability can be further improved.

As any binder that can be contained in the oral composition, any suitable organic binder conventionally known, for example, a polysaccharide, a cellulosic binder (for example, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, etc.) Hydroxypropyl methylcellulose, methylcellulose, cationized cellulose, etc.), other polysaccharide thickeners (eg, xanthan gum, gua gum, gellan gum, tragant gum, karaya gum, arabiya gum, locust bean gum, carrageenan, sodium alginate, propylene glycol alginate), synthetic water Examples thereof include sex polymers (eg, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol). The content of any binder is preferably 0 to 1% by mass, more preferably 0.1 to 0.8% by mass.

-PH regulator-
The oral composition of the present embodiment may contain a conventionally known arbitrary suitable pH adjuster as an arbitrary suitable content. When the oral composition contains a pH adjuster, the pH stability of the oral composition can be ensured.

Examples of the pH adjuster include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid and lactic acid or salts thereof, and inorganic acids such as phosphoric acid (orthoric acid) or salts thereof. (For example, potassium salt, sodium salt and ammonium salt), hydroxides such as sodium hydroxide and potassium hydroxide can be mentioned. Examples of the inorganic acid salt include disodium hydrogen phosphate and sodium dihydrogen phosphate.

The content of the pH adjuster can usually be such that the pH of the oral composition after addition is 5 to 9, preferably 6 to 8.5.

In the present specification, the pH value usually means a value at 25 ° C. after 3 minutes have passed from the start of measurement. The pH value can be measured using, for example, a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

-Colorant-
The oral composition of the present embodiment may contain a conventionally known arbitrary suitable colorant as an arbitrary suitable content.

Colorants that can be contained in the oral composition include, for example, Benibana red pigment, gardenia yellow, gardenia blue pigment, perilla pigment, red koji pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, and the like. Natural pigments such as tamarind pigments and legal regulations such as red 2, red 3, red 104, red 105, red 106, red 227, yellow 4, yellow 5, green 3, and blue 1. Examples include dyes, riboflavin, sodium copper chlorofin, titanium dioxide and the like. When the oral composition contains a colorant, the content thereof is preferably 0.00001 to 3% by mass with respect to the entire oral composition.

-Other optional ingredients-
The oral composition of the present embodiment may contain an arbitrary component other than the above as an arbitrary suitable content.

[Dosage form and use of oral composition]
The oral composition of the present invention can be in any suitable dosage form by any suitable method according to a conventional method. Dosage forms include, for example, liquids (solutions, emulsions, suspensions, syrups, etc.), semi-solids (gels, creams, pastes, etc.), solids (tablets, particulate agents, capsules, film agents, kneaded products, melts, etc.). Solids, waxy solids, elastic solids, soft capsules, etc.). The dosage form of the oral composition is preferably liquid or semi-solid.

The oral composition of the present invention can be widely used in oral applications. Applications in solid dosage forms include, for example, troches, gummies, gums, powders or tablets of dentifrices. Examples of applications in the semi-solid dosage form include dentifrices and gel-like dentifrices. Examples of applications in the form of liquids include mouthwashes, liquid dentifrices, and mouthwashes (sprays and the like). The oral composition of the present invention realizes a good moisturizing sensation, suppresses a squeaky feeling, and can improve physical properties such as shape retention and spinnability. Therefore, a dentifrice (dentifrice, gel) can be obtained. It is preferably a dentifrice) or a coating agent (oral moisturizing gel, oral moisturizing claim).

[Manufacturing method of oral composition]
The method for producing the oral composition of the present invention is not particularly limited. Oral compositions can be prepared by their respective conventional methods, depending on the dosage form selected. For example, when the oral composition is used as a dentifrice, a component that dissolves in a solvent is first prepared, and then other insoluble components are mixed, and if necessary, the pressure is reduced, for example, to further remove the composition. A manufacturing method for foaming can be mentioned. The dentifrice thus obtained can be made into a product by accommodating it in a tube container such as a laminated tube or a pump-type container.

The shape and material of the container in which the oral composition of the present invention can be contained are not particularly limited. Any suitable conventionally known container used for the oral composition can be used. Examples of the container include a container made of a plastic material such as polyethylene, polypropylene, polyethylene terephthalate, and nylon.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. The present invention is not limited to the following examples. Unless otherwise specified, the numerical values in the table indicate the pure content (AI amount) and mass% of each component.

[Ingredients used in Examples and Comparative Examples]
First, the components used in Examples and Comparative Examples will be described.
(A) Inorganic silicic acid (silica): manufactured by Solvay, Tixosil (registered trademark) 73 (average particle size (volume standard D50): 9 μm)
(B) N-ethyl-p-menthan-3-carboxamide: N- (4-cyanomethylphenyl) -p-menthancarboxamide manufactured by Symrise: 3-l-mentoxypropane-1,2-diol manufactured by Dibodan: Takasago Perfume Industry Co., Ltd. (C) Dipotassium glycyrrhizinate: Maruzen Pharmaceuticals Co., Ltd. (D) Concentrated glycerin (99.5%): Sakamoto Pharmaceutical Co., Ltd., Concentrated glycerin polyethylene glycol for cosmetics: Sanyo Kasei Kogyo Co., Ltd. Polyethylene glycol 400
(Components other than component (A) to component (D))
Carboxymethyl cellulose (CMC): CMC1260 manufactured by Dycel Finechem Co., Ltd.
Sodium monofluorophosphate Sodium saccharinso Polyoxyethylene (20) Hardened castor oil Fragrance For the above ingredients, raw materials conforming to the quasi-drug raw material standard 2006 were used.

Examples 1 to 16 and Comparative Examples 1 to 6 (test oral composition)
Using the above-mentioned components, a test oral composition having the composition shown in Tables 1 to 3 below was prepared according to the following preparation method.

The viscosities of the obtained test oral compositions were all in the range of 20 to 100 Pa · s at 25 ° C.
The water content of the test oral composition was calculated as a ratio (mass%) of the total water content contained in the raw materials before compounding to all the raw materials, and is shown in Tables 1 to 3 below.

[Preparation method of test oral composition]
The raw materials shown in Tables 1 to 3 below are blended by a conventional method, mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kosakusho Co., Ltd.), defoamed under reduced pressure (pressure 4 kPa), and dentifrice (dentifrice). ) Was obtained.

The obtained test oral composition was evaluated by the following procedure. The evaluation results are shown in Tables 1 to 3 below.

[Evaluation methods]
-Evaluation of moisturizing feeling in the oral cavity after use-
1 g of the test oral composition was placed on the brush of a toothbrush (Clinica Advantage toothbrush, 4-row compact, usually manufactured by Lion: the same applies to the toothbrush used in the following evaluation method), and the tester brushed it in the usual manner. The moisturizing sensation in the oral cavity after rinsing (after use) was evaluated on a 5-point scale. Specifically, the average score of 10 examiners who scored according to the following scoring criteria was calculated, and based on this, evaluation was made on a 5-point scale of excellent, excellent, good, acceptable, and unacceptable. The results are shown in Tables 1 to 3 below.

(Score criteria)
5 points: Feel the moisturizing feeling in the oral cavity 4 points: Feel the moisturizing feeling in the oral cavity 3 points: Feel the moisturizing feeling in the oral cavity a little 2 points: Feel the moisturizing feeling in the oral cavity almost 1 point: In the oral cavity I do not feel any moisturizing feeling (evaluation criteria)
Excellent: Average 4.5 points or more and 5.0 points or less Excellent: Average 4.0 points or more and less than 4.5 points Good: Average 3.0 points or more and less than 4.0 points Possible: Average 2.0 points or more and 3.0 No less than points: 1.0 points or more and less than 2.0 points on average

-Evaluation of powder squeaky feeling at the beginning of polishing-
When 1 g of the test oral composition was placed on the brush of a toothbrush and the examiner started brushing by a usual method, the lack of powdery sensation in the oral cavity was evaluated on a 5-point scale according to the following scoring criteria. .. The average score of 10 testers was calculated and evaluated on a 4-point scale as excellent, good, acceptable, and unacceptable according to the following evaluation criteria. The results are shown in Tables 1 to 3 below.

(Score criteria)
5 points: No powder squeaky feeling at the beginning of polishing 4 points: Almost no powder squeaky feeling at the beginning of polishing 3 points: Slightly felt powder squeaky feeling at the beginning of polishing but allowable range 2 points: Powder squeaky feeling at the beginning of polishing 1 point to feel the feeling: I strongly feel the powdery squeaky feeling at the beginning of polishing (evaluation standard)
Excellent: Average 4.0 points or more and 5.0 points or less Good: Average 3.0 points or more and less than 4.0 points Possible: Average 2.5 points or more and less than 3.0 points Impossible: Average 1.0 points or more 2.5 Less than a point

-Evaluation of spinnability-
First, the test oral composition is filled in a laminated tube having an inner diameter of 8 mm, and then the test oral composition is extruded from the laminated tube onto a toothbrush brush, and about 1 g is placed on the laminated tube, and then the laminated tube and the toothbrush are upwardly loaded. Test when the toothbrush was pulled apart The breakage (spinning property) of the oral composition was tested.

The spinnability was evaluated on a 4-point scale as excellent, good, acceptable, and unacceptable according to the following evaluation criteria, which can be evaluated by measuring the length of the filamentous portion drawn by the test oral composition. The results are shown in Tables 1 to 3 below.

(Evaluation criteria)
Excellent: Spinnability is less than 0.5 cm and sharpness is good (usability is good).
Good: Spinnability of 0.5 cm or more and less than 0.7 cm is observed (no problem with usability).
Possible: Spinning property of 0.7 cm or more and less than 1 cm is recognized (although there is a slight problem in usability, it is acceptable).
Impossible: Spinning property of 1 cm or more is recognized (problem with usability)

-Evaluation of shape retention when extruded from laminated tube-
The test oral composition is filled in a laminated tube having an inner diameter of 8 mm, the test oral composition is extruded from the laminated tube onto a toothbrush, and the state (shape retention) immediately after about 1.0 g is applied is as follows. According to the evaluation criteria, it was evaluated as evaluation A, evaluation BH, evaluation BS, evaluation CH, and evaluation CS. The results are shown in Tables 1 to 3 below.
(Evaluation criteria)
A: The extruded test oral composition retains its shape and does not drip from the toothbrush (good usability).
BH: The extruded test oral composition is in the form of a hard paste, but does not roll off the toothbrush (no problem with usability).
BS: The extruded test oral composition slightly loses its shape but does not fall off the toothbrush (no problem with usability).
CH: The extruded test oral composition is in the form of a hard paste and rolls off the toothbrush (problems with usability).
CS: Extruded test oral composition loses its shape and drips from the toothbrush (problems with usability)

In Comparative Examples 1 to 6 which did not satisfy the above requirements of the present invention, the evaluation of the moisturizing feeling in the oral cavity, particularly the powdery squeaky feeling at the initial stage of use (beginning of polishing), the spinnability, and the shape retention was low. On the other hand, in Examples 1 to 16 satisfying the above requirements of the present invention, the evaluation of the moisturizing feeling in the oral cavity, the powdery squeaking feeling at the initial stage of use, the spinnability, and the shape-retaining property were all good.
In addition, when toothbrushing was performed using the oral composition and the toothbrush according to Examples 1 to 15 and Comparative Examples 1 to 6 in which glycerin and polyethylene glycol were used in combination, the examiner was irritated during brushing. I could feel no good warmth.

Claims

Contains (A) inorganic powder and (B) cooling sensitizer
The content of the surfactant is 0.5% by mass or less,
An oral composition having a water content of 2% by mass or less.
(B) The cooling agent is N-ethyl-p-menthane-3-carboxamide, menthyllactate, menthylmonosuccinate, isopregol, mentonglycerol ketal, N- (4-cyanomethylphenyl) -p-menthancarboxamide, 3 -L-mentoxypropane-1,2-diol, 5-methyl-2-propane-2-yl-N- (2-pyridine-2-ylethyl) cyclohexane-1-carboxamide, 3- (p-menthane-3) -Carboxamide) The oral composition according to claim 1, which is at least one selected from the group consisting of ethyl acetate, 2-isopropyl-N, and 2,3-trimethylbutylamide.
(A) The oral composition according to claim 1 or 2, wherein the content of the inorganic powder is 2 to 50% by mass.
(B) The oral composition according to any one of claims 1 to 3, wherein the content of the cooling sensation agent is 0.0001 to 0.3% by mass.
(C) The oral composition according to any one of claims 1 to 4, further comprising one or more selected from the group consisting of glycyrrhetinic acid and glycyrrhizic acid and a salt thereof.
The oral composition according to any one of claims 1 to 5, further comprising (D) a solvent, and (D) a polyhydric alcohol having a melting point of 25 ° C. or lower.
The oral composition according to any one of claims 1 to 6, which is a dentifrice or a coating agent.