CN102365077B - Composition for oral cavity - Google Patents
Composition for oral cavity Download PDFInfo
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- CN102365077B CN102365077B CN201080015684.2A CN201080015684A CN102365077B CN 102365077 B CN102365077 B CN 102365077B CN 201080015684 A CN201080015684 A CN 201080015684A CN 102365077 B CN102365077 B CN 102365077B
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- oral cavity
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- betaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
A composition for the oral cavity which comprises: (A) at least one kind of copper compound selected from copper gluconate, copper sulfate and hydrates of the same; (B) a betaine-type amphoteric surfactant; and (C) at least one kind of sugar alcohol selected from ethythritol, xylitol and mannitol. This composition for the oral cavity gives an actual feeling of improving periodontal disease by exerting a sufficient gum-tightening effect and, at the same time, exhibits effects of relieving an unpleasant bitterness characteristic to copper compounds and reducing irritation to the oral mucosa, thereby achieving an excellent feel in using.
Description
Technical field
The present invention relates to the composition for oral cavity that contains copper compound that a kind of use is felt good, it is for the dental bed that periodontal disease is improved the effectual sensation of effect, have to give and tighten up fully the sense effect, and, brought into play for the peculiar not well bitterness of copper compound improve effect and to the inhibition of oral cavity mucosa irritation.
Background technology
In the past, because of copper gluconate, copper citrate, the copper compounds such as copper sulfate have antibacterial effect, antihalitosis effect and the effect that prevents from forming tartar, various motions about the composition for oral cavity that cooperates copper compound are arranged, and about various copper compounds source, for the technology motion that improves effect and prevent variable color (with reference to patent documentation 1～5: Japanese patent laid-open 2-212413 communique, Japanese patent laid-open 8-310928 communique, No. 2882017 communique of Japan Patent, the flat 10-505831 communique of the special table of Japan Patent, Japanese Patent Laid-Open 2003-231621 communique).
Generally, copper compound plays for the dental bed that periodontal disease is improved the effectual sense of effect and tightens up effect, as having the composition that works to tightening up, suitably is used in the medicine etc. of toothpaste and treatment periodontal disease.
But copper compound has the not well tastes such as bitterness and metallic taste, in addition, also can stimulate oral mucosa, but to just have in composition for oral cavity, cooperate to advance the copper compound of capacity in order to bring into play gratifying effect, thereby cause reducing the problem of using sensation.So far, proposed a lot of solutions, in patent documentation 6 (Japanese Patent Laid-Open 2003-137755 communique), the applicant is proposed in the chemical compound that can discharge the metal ions such as copper by cooperating menthol derivative etc. to improve metallic taste.
Yet, through inventor research, if improved not well tastes such as bitterness from copper compound, because can damage simultaneously tightening up the sense effect and causing the reduction of actual effect sense of giving, used the technology of feeling for former improvement, also leave some room for improvement in this.On the other hand, if suppressed the stimulation to oral mucosa that copper compound brings, then suppress simultaneously to give the effect of tightening up sense, if do not lose that copper compound brings gratifyingly tighten up sense, only suppress very difficult to the stimulation meeting of oral mucosa.
So, for the inhibition of improving effect and oral mucosa being stimulated of the not well bitterness in copper compound source, tighten up fully the sense effect with giving for dental bed, have both simultaneously the exploitation of the two technology and extremely expect.The known technology document
Patent documentation
Patent documentation 1: Japanese patent laid-open 2-212413 communique
Patent documentation 2: Japanese patent laid-open 8-310928 communique
Patent documentation 3: No. 2882017 communique of Japan Patent
Patent documentation 4: the flat 10-505831 communique of the special table of Japan Patent
Patent documentation 5: Japanese Patent Laid-Open 2003-231621 communique
Patent documentation 6: Japanese Patent Laid-Open 2003-137755 communique
Patent documentation 7: Japanese Patent Laid-Open 2000-297022 communique
Patent documentation 8: Japanese Patent Laid-Open 2008-150335 communique
Patent documentation 9: Japanese Patent Laid-Open 2007-320894 communique
Summary of the invention
The problem that invention will solve
The purpose of this invention is to provide the composition for oral cavity that contains copper compound that a kind of use is felt good, it is for the dental bed that periodontal disease is improved the effectual sense of effect, have to give and tighten up fully the sense effect, and, brought into play for the peculiar not well bitterness of copper compound improve effect and to the inhibition of oral cavity mucosa irritation.
Solve the means of problem
The inventor in order to achieve the above object, found that through concentrating on studies, by in composition for oral cavity, cooperating the copper compound more than a kind, (B) betaine type amphoteric surfac-tant that (A) select from copper gluconate, copper sulfate and hydrate thereof and the sugar alcohol more than a kind of (C) from erithritol, xylitol and mannitol, selecting to use together, the inhibition of improving effect and oral mucosa being stimulated for the not well bitterness in copper compound source, tighten up fully the sense effect with giving for dental bed, can have both these effects.
In containing the composition for oral cavity of copper compound, the bitterness in copper compound source, to the stimulation of oral mucosa, and tighten up sense, be with the oral cavity in the mucosa result that interacts and cause.Namely, in the aforesaid composition for oral cavity that contains copper compound, for the not well taste such as the bitterness that suppresses copper compound source with to the stimulation of oral mucosa, do not damage again simultaneously and give the effect of tightening up sense, consider the interaction of mucosa in copper compound and the oral cavity is changed.To this, the present invention is in copper gluconate, copper sulfate or its hydrate, with betaine type amphoteric surfac-tant and sugar alcohol co-action, the interaction of mucosa and above-mentioned different in copper compound and the oral cavity, by these variations, thereby infer the bitterness to improve the copper compound source, suppress the stimulation to oral mucosa, can also keep simultaneously and fully tighten up the sense effect to what dental bed was given.
Action effect such among the present invention has obtained confirmation from embodiment described later.It consists of essential condition any one shortcoming the present invention, for example replacing the betaine type amphoteric surfac-tant with amino acid type amphoteric surface active agent uses, even sugar alcohol is arranged for another example, replace above-mentioned (C) composition and use with Sorbitol or glycerol, these all miss one's aim, and only have to have satisfied the present invention all consist of essential conditions and just can achieve the goal.
Moreover well-known, as the gradation composition of composition for oral cavity, sugar alcohol is to be used as common wetting agent etc.Japanese Patent Laid-Open 2008-150335 communique), combination by double-glycine acid copper and xylitol obtained to show that the compositions (patent documentation 4) of improving the oral disease effect etc. is disclosed further, by cooperating sugar alcohol to improve the technology (patent documentation 7: Japanese Patent Laid-Open 2000-297022 communique), improve the technology (patent documentation 8: of long-time storage stability by in the compositions that contains fluorine compounds and sodium lauryl sulfate and trimethyl glycine, cooperating erithritol of the variable color of the plant extract preparation that contains polyphenyl phenol.In addition, as the technology that in composition for oral cavity, cooperates amphoteric surfactant, Japanese Patent Laid-Open 2007-320894 communique) etc. by in containing the dentifrice composition of fluorine compounds, cooperating sodium lauryl sulfate and cation property copolymer and betaine type amphoteric surfac-tant, fluorine compounds have been improved at intraoral anelasticity and the technology (patent documentation 9: also be suggested that uses sensation etc.Further, the applicant has proposed in containing the composition for oral cavity of copper compound as wetting agent, the technology (patent documentation 1) that cooperates the sugar alcohol of content of reducing sugar below 0.2 quality % also has, and cooperates the technology (patent documentation 3) of amphoteric surfactant.These technology, can prevent the long-time variable color that causes because of copper compound and the effect that keeps antihalitosis, but different from problem to be solved by this invention, although any one all belongs to formation of the present invention, but do not show technological thought of the present invention and action effect.
Such as about the composition for oral cavity that contains copper compound various motions being arranged like this, and sugar alcohol and amphoteric surfactant are also known by the people as the gradation composition of composition for oral cavity.But, in the composition for oral cavity that contains copper gluconate, copper sulfate or its hydrate, by cooperating betaine type amphoteric surfac-tant and combination as erithritol, xylitol or the mannitol of sugar alcohol, do not damage copper compound source excellence give the effect of tightening up sense, improved satisfactorily simultaneously the not well bitterness in copper compound source and to the stimulation of oral mucosa, this is the inventor's new discovery.
Therefore, the present invention aims to provide a kind of composition for oral cavity, it is characterized in that,
The copper compound more than a kind that contains that (A) choose from copper gluconate, copper sulfate and hydrate thereof,
(B) betaine type amphoteric surfac-tant,
The sugar alcohol more than a kind of (C) from erithritol, xylitol and mannitol, selecting.
The effect of invention
The composition for oral cavity that contains copper compound of the present invention, for being given, the dental bed that improves the effectual sense of periodontal disease effect tightens up fully the sense effect, and brought into play improving effect and to the inhibition of the stimulation of oral mucosa, using sensation excellent the distinctive not well bitterness of copper compound.
The specific embodiment
Below, the present invention will be described in detail.Composition for oral cavity of the present invention is characterised in that and contains, the copper compound of (A) choosing from copper gluconate, copper sulfate and hydrate thereof, (B) betaine type amphoteric surfac-tant and the sugar alcohol more than a kind of (C) selecting from erithritol, xylitol and mannitol.
As the copper compound of (A) composition, use copper gluconate, copper sulfate, can a kind independent use also can 2 kinds and use.Copper gluconate and copper sulfate can be respectively acid anhydride or hydrate.As hydrate, can use as: copper sulfate 5 hydrates, 3 hydrates, 1 hydrate etc. contain the hydrate of water of crystallization.
The combined amount of copper compound, preferably copper accounts for 0.0026～0.51% overall (quality %, lower with) of compositions in the chemical compound, and particularly preferably 0.013～0.26%, especially preferred 0.026～0.26%.If combined amount is less than 0.0026%, giving the effect of tightening up sense and may being not in full use of copper compound source is difficult to give full play to the effect of improving bitterness if surpass 0.51%, sometimes also can improve unsatisfactorily and use sensation.
As the betaine type amphoteric surfac-tant of (B) composition, can enumerate: lauryl betaine, stearyl betaine, lauryl dimethyl aminoacetic acid betanin, stearic dimethylamino acetic acid betanin, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine, dodecyl acid amido propyl betaine, coco-nut oil fatty acid amido propyl betaine, lauryl hydroxyl sulfo betaine etc.Wherein, preferably from lauryl dimethyl aminoacetic acid betanin, coco-nut oil fatty acid amido propyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine.These betaine type amphoteric surfac-tants can also can use more than 2 kinds in the lump in a kind of independent use.
The betaine type amphoteric surfac-tant can use commercially available product, changes into the 2-alkyl that industrial commercial firm makes-N-carboxymethyl-N hydroxyethyl imidazolinium betaine (trade name LEBON 105), N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine (trade name LEBON 101-H), coco-nut oil fatty acid amido propyl betaine liquid (trade name LEBON2000), lauryl dimethyl aminoacetic acid aqueous solutions of betaine (trade name NIKKOL AM-301) that day photochemistry commercial firm makes etc. such as: Sanyo.As 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, but the 2-Oleum Cocois alkyl of commodity in use エ Na ジ コ one Le C-40H by name, Lion Corporation's sale-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine sodium water solution.
Betaine type amphoteric surfac-tant's combined amount, be preferably compositions overall 0.01～5%, particularly preferably 0.05～2%, especially preferred 0.1～1%.If combined amount, then can not be given full play to the inhibition that oral mucosa is stimulated sometimes less than 0.01%, if surpass 5% problem that oral mucosa can occur to stimulate because of surfactant, sometimes can not give full play in addition the effect of improving to bitterness.
(C) composition is the sugar alcohol of selecting from erithritol, xylitol and mannitol.These sugar alcohols can a kind use separately, also can 2 kinds or 3 kinds use in the lump.2 kinds when using in the lump, preferably use in the lump erithritol and xylitol.
(C) combined amount of composition sugar alcohol be compositions overall 2～50%, particularly preferably 5～30%, especially preferred 10～30%.If combined amount less than 2%, then can not be given full play to the effect of improving to bitterness sometimes, if surpass 50% can hinder that copper compound gives tighten up the sense effect, in addition, sometimes can not give full play to the inhibition that oral mucosa is stimulated.
Composition for oral cavity of the present invention can be mixed with the toothpaste such as ordinary toothpaste, wet type toothpaste, liquid tooth paste, collutory, gel, ointment, oral cavity freshener, the various dosage forms such as using tablet, oral cavity ointment, chewing gum of gargling, be particularly suitable for preparing toothpaste and gel, especially gel.If be mixed with such dosage form, reflect the more effective effect than the present invention.In these preparations, except above-mentioned essential component, according to the dosage form needs, in the scope of not damaging effect of the present invention, also can cooperate other composition, can prepare by conventional method.
As other composition, for example during the situation of toothpaste, can cooperate various grinding agents, wetting agent, binding agent, surfactant, and can cooperate sweeting agent as required, spice, stain, antiseptic, pH adjusting agent and other effective ingredient etc.During the situation of gel, can cooperate wetting agent, binding agent, surfactant and can cooperate as required sweeting agent, spice, stain, antiseptic, pH adjusting agent, alcohol, oiliness composition and other effective ingredient etc.
Can enumerate as grinding agent: precipitability silicon dioxide, silica gel, aluminosilicate, zeolite, zirconium silicate, calcium monohydrogenphosphate 2 hydrates and acid anhydride thereof, calcium pyrophosphate, calcium carbonate, aluminium hydroxide, aluminium oxide, magnesium carbonate, magnesium phosphate, insoluble Polymeric sodium metaphosphate., insoluble potassium metaphosphate, titanium oxide, hydroxyapatite, synthetic resin grinding agent etc. (combined amount: be generally compositions overall 5～50%).
As wetting agent, material except (C) composition sugar alcohol can be enumerated such as polyhydric alcohol such as Sorbitol, glycerol, propylene glycol, Polyethylene Glycol, 1,3 butylene glycols.When cooperating wetting agent, its use level is generally 10～50%.
Can enumerate as binding agent: the synthetic binders (combined amount is generally 0.5～10%) such as the gummy class such as alginic acid derivant, guar gum, xanthan gum, arabic gum, carrageenin, animal glue, polyvinyl alcohol, sodium polyacrylate, carboxyl ethylene polymer, polyvinylpyrrolidone such as the cellulose derivatives such as sodium carboxymethyl cellulose, hydroxy ethyl cellulose, sodium alginate, propylene glycol alginate.
As surfactant, except the betaine type amphoteric surfac-tant of (B) composition, can cooperate such as nonionic surfactant, anionic surfactant and cationic surfactant.
As nonionic surfactant, ether type or the fatty acid fat alkylolamides classes such as ester type surfactant, lauric acid diethyl amide such as polyol fatty acid ester, polyoxyethylene alkyl ether, poloxalkol, polyoxyethylene alkyl phenyl ether, the polyoxyethylene hardened castor oils such as the sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, fatty acid glyceride, polyglyceryl fatty acid ester, polyoxyethylene fatty acid glyceride, cithrol.
Can enumerate as the anionic surfactant: sodium lauryl sulfate; the alkyl sulfates such as sodium tetradecyl sulfate; N-lauroyl sarcosine sodium; the N-acyl group sarcosine sodium such as N-myristoyl sarcosine sodium; dodecylbenzene sodium sulfonate; hydrogenated coconut glycerine monofatty ester sulfate mono sodium; lauryl alcohol sulfoacetic acid sodium; the N-acylaminoglutaricamiderivative hydrochlorates such as N-palmityl sodium glutamate; N-methyl-N-acyl group taurine sodium; N-methyl-N-acyl amino sodium propionate; alpha-olefin sodium sulfonate etc.As cationic surfactant alkylammonium, alkylbenzene methyl ammonium salt etc. are arranged for example.
During as these surfactants of any components matching, its combined amount is generally 0.01～2%.
Moreover anionic surfactant's among the present invention, particularly sodium lauryl sulfate etc. alkyl sulfate reduces the tendency of using sensation because having, and preferably mismatches.When cooperating the situation of anion surfactant, its combined amount is preferred below 0.5%, and particularly preferably 0～0.1%, 0% also can.Especially preferably mismatch.
Can enumerate as sweeting agent: saccharin sodium, stevioside, Stevia rebaudiana (Bertoni) Hemsl extract, p-met hoxycinnamic aldehyde, neohesperidin base oxidation chalcone derivative, perillartine etc.
Can enumerate as stain: blue No. 1 (FD﹠amp; C Blue No.1 (42090)), yellow No. 4 (FD﹠amp; C Yellow No.5 (19140)), titanium dioxide etc.Can enumerate as antiseptic: the benzoic acid such as p-Hydroxybenzoate, sodium benzoate or its salt etc.Can enumerate as spice: the terpenoid such as l-menthol, carvone, anethole, limonene and derivant thereof, Herba Menthae wet goods.
Can enumerate as pH adjusting agent: citric acid, fumaric acid, malic acid, tartaric acid, lactic acid etc.
Can enumerate as alcohol: the lower alcohol of the carbon numbers such as ethanol below 3.When cooperating alcohol, its combined amount is generally 1～20%.
The oiliness composition can be enumerated: liquid paraffin, liquid paraffin,light, hard paraffin, ceresine, microwax, Squalene, the hydrocarbon ils such as squalene, dodecyl acid, myristic acid, Palmic acid, stearic acid, lauroleic acid, oleic acid, eicosatetraenoic acid, linoleic acid, linolenic acid, the fatty acids such as ricinoleic acid, oleum lini, siritch, safflower oil, Oleum Glycines, Semen Maydis oil, Oleum Brassicae campestris, Oleum Gossypii semen, olive oil, Camellia oil, Oleum Ricini, the cocoa resin, Petiolus Trachycarpi oil, Cortex cocois radicis wet goods vegetable oil, Adeps Bovis seu Bubali, Adeps Sus domestica, house oil, the animal wet goods such as Adeps caprae seu ovis.Wherein, considering preferred hydrocarbon ils, more preferably liquid paraffin, liquid paraffin,light aspect the intraoral anelasticity from preparation.When cooperating the oiliness composition, its combined amount is generally 0.1～10%.
Effective ingredient can be enumerated, except (A) composition copper compound, as: the vitaminss such as ascorbic acid (vitamin C) salt vitamin E (tocopherol) ester, glucanase, become dextranase, the enzyme of lysozyme etc., Cortex Phellodendri extract, the Radix Scutellariae extract, the crude drug compositions such as Flos Caryophylli extract, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, dequalinium chloride, chlorhexidine hydrochloride, the gluconic acid chlorhexidine, triclosan, isopropyl methyl phenol, order cypress alcohol waits antibacterial, sodium chloride, polyphosphate sodium, Polymeric sodium metaphosphate., sodium phosphate, sodium tripolyphosphate, aluctyl., the inorganic salts such as chitosan or organic salt etc.In addition, the combined amount of these effective ingredient is sneaked into effective dose in not hindering effective scope of the present invention.
Embodiment
Below, by embodiment and comparative example, more be described in detail the present invention, but the present invention is not limited by following embodiment.Combined amount in the following example all refers to quality %.In addition, be the composition of aqueous solution about form, any one that shows in the table all represents to be scaled the combined amount of pure material.
(embodiment, comparative example)
The composition for oral cavity (gel) that preparation forms shown in table 1～4 is coated on the about 0.5g of composition for oral cavity on 5 members' of expert group the gingiva with finger.The inhibition of tightening up the sense effect, oral mucosa being stimulated of just after the coating dental bed having been given, to the improving effect, carry out subjective appreciation by 4 grades of scoring benchmark as follows respectively of bitterness, press afterwards commentary valency benchmark and assess.The result is shown in table 1～5.In addition, the details of gradation composition is as shown in table 6.
Give the effect of tightening up sense:
Scoring
4 minutes: feel to tighten up sense
3 minutes: arrive in a little and tighten up sense
2 minutes: almost imperceptiblely tighten up sense
1 minute: imperceptiblely tighten up sense
Give the metewand that tightens up the sense effect:
◎: give the average mark more than 3.5 minutes below 4.0 minutes that tightens up the sense effect
Zero: give tighten up the sense effect average mark more than 3.0 minutes 3.5 minutes less than
△: give tighten up the sense effect average mark more than 2.0 minutes 3.0 minutes less than
*: give the average mark 2.0 minutes that tightens up the sense effect less than
Inhibition to the oral mucosa stimulation:
Scoring
4 minutes: complete imperceptible stimulation
3 minutes: almost imperceptible stimulation
2 minutes: feeling a little stimulated
1 minute: feeling stimulated
Oral mucosa is stimulated the metewand of inhibition:
◎: the average mark that oral mucosa is stimulated inhibition is more than 3.5 minutes below 4.0 minutes
Zero: the average mark that oral mucosa is stimulated inhibition more than 3.0 minutes 3.5 minutes less than
△: the average mark that oral mucosa is stimulated inhibition more than 2.0 minutes 3.0 minutes less than
*: the average mark 2.0 minutes that oral mucosa is stimulated inhibition less than
The effect of improving to bitterness:
Scoring
4 minutes: complete imperceptible bitterness
3 minutes: imperceptible bitterness almost
2 minutes: feel a little bitterness
1 minute: feel bitterness, or stimulate strong
Bitterness is improved the metewand of effect:
◎: the average mark that bitterness is improved effect is more than 3.5 minutes below 4.0 minutes
Zero: the average mark that bitterness is improved effect more than 3.0 minutes 3.5 minutes less than
△: the average mark that bitterness is improved effect more than 2.0 minutes 3.0 minutes less than
*: the average mark 2.0 minutes that bitterness is improved effect less than
[table 1]
[table 2]
[table 3]
[table 4]
[table 5]
[table 6]
| Composition | The manufacturer | Trade name |
| Copper sulfate pentahydrate | Kanto Kagaku K. K. | Copper sulfate pentahydrate |
| Copper gluconate | With the pure medicine of light Co., Ltd. | Copper gluconate |
| 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine | Sanyo Chemical Industries, Ltd. | LEBON 105 |
| N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine | Sanyo Chemical Industries, Ltd. | LEBON 101-H |
| Coco-nut oil fatty acid amido propyl betaine liquid | Sanyo Chemical Industries, Ltd. | LEBON 2000 |
| Lauryl dimethyl aminoacetic acid aqueous solutions of betaine | Nikko Chemicals Co., Ltd | NIKKOL AM-301 |
| β-laurylamino-propionic acid sodium | Sanyo Chemical Industries, Ltd. | LEBON APL |
| Erithritol | Mitsubishi-kagaku Foods Corp. | Erithritol |
| Xylitol | Mitsubishi Food Technology Co., Ltd | Xylitol |
| Mannitol | ROQUETTE commercial firm | PEARITOL (registered trade mark) 50C |
| Sorbitol | MERCK commercial firm | Parteck SI 150 |
| Glycerol | Asahi Denka Kogyo K. K | Glycerol |
Claims (4)
1. a composition for oral cavity is characterized in that, contains
(A) copper compound more than a kind of choosing from copper gluconate, copper sulfate and hydrate thereof is expressed as 0.013～0.26 quality % with copper,
(B) betaine type amphoteric surfac-tant 0.05～2 quality % and
(C) 5～30 quality % of sugar alcohol more than a kind that from erithritol, xylitol and mannitol, select.
As in the claim 1 record composition for oral cavity, wherein, the betaine type amphoteric surfac-tant is selected from one kind or two or more in lauryl dimethyl aminoacetic acid betanin, coco-nut oil fatty acid amido propyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine and N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine.
3. such as the composition for oral cavity of claim 1 or 2 records, be formulated into toothpaste or gel.
As claim 1 or 2 the record composition for oral cavity, wherein,
(C) composition is that erithritol and xylitol are used in the lump.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009-081716 | 2009-03-30 | ||
| JP2009081716 | 2009-03-30 | ||
| PCT/JP2010/054910 WO2010113688A1 (en) | 2009-03-30 | 2010-03-23 | Composition for oral cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102365077A CN102365077A (en) | 2012-02-29 |
| CN102365077B true CN102365077B (en) | 2013-10-16 |
Family
ID=42827983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080015684.2A Active CN102365077B (en) | 2009-03-30 | 2010-03-23 | Composition for oral cavity |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP5930713B2 (en) |
| KR (1) | KR101649003B1 (en) |
| CN (1) | CN102365077B (en) |
| HK (1) | HK1163509A1 (en) |
| WO (1) | WO2010113688A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999363B (en) | 2014-12-12 | 2021-04-06 | 狮王株式会社 | Oral composition |
| JP7347416B2 (en) | 2018-05-29 | 2023-09-20 | ライオン株式会社 | Oral composition |
| CN112041030B (en) * | 2018-07-17 | 2023-08-15 | 日本泽托克株式会社 | Nonaqueous oral care compositions |
| EP3603626A1 (en) * | 2018-07-31 | 2020-02-05 | Mucosa Innovations, S.L. | Composition for use in the prevention and/or treatment of the genitourinary mucosa |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158081A (en) * | 1994-09-15 | 1997-08-27 | 普罗克特和甘保尔公司 | Oral compositions |
| EP0920857A2 (en) * | 1997-11-06 | 1999-06-09 | Dentaid, S.A. | Oral composition for the treatment of halitosis |
| CN1960696A (en) * | 2004-03-29 | 2007-05-09 | 高露洁-棕榄公司 | Improved dental whitening method |
| CN1993104A (en) * | 2004-06-02 | 2007-07-04 | 高露洁-棕榄公司 | Anti-staining antibacterial dentifrice |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57171909A (en) * | 1981-04-15 | 1982-10-22 | Lion Corp | Composition for oral cavity |
| JP2785298B2 (en) * | 1989-02-10 | 1998-08-13 | ライオン株式会社 | Oral composition |
| JP2882017B2 (en) * | 1990-09-19 | 1999-04-12 | ライオン株式会社 | Oral composition |
| JPH08310928A (en) * | 1995-05-15 | 1996-11-26 | Lion Corp | Dentifrice composition |
| JP2000297022A (en) | 1999-04-12 | 2000-10-24 | Lion Corp | Composition for oral cavity |
| JP2003137755A (en) | 2001-11-02 | 2003-05-14 | Lion Corp | Composition for oral cavity |
| ES2346856T3 (en) * | 2001-11-28 | 2010-10-21 | THE PROCTER & GAMBLE COMPANY | DENTIFRICO COMPOSITIONS. |
| JP2003231621A (en) | 2002-02-06 | 2003-08-19 | Lion Corp | Composition for oral cavity for preventing foul breath |
| JP2007008824A (en) * | 2005-06-28 | 2007-01-18 | Lion Corp | Composition for oral cavity |
| JP2007320894A (en) | 2006-05-31 | 2007-12-13 | Lion Corp | Toothpaste composition |
| JP4825122B2 (en) | 2006-12-19 | 2011-11-30 | ライオン株式会社 | Dentifrice composition |
| JP4919060B2 (en) * | 2007-06-28 | 2012-04-18 | ライオン株式会社 | Oral composition and algin dipine inhibitor |
-
2010
- 2010-03-23 KR KR1020117022572A patent/KR101649003B1/en active IP Right Grant
- 2010-03-23 CN CN201080015684.2A patent/CN102365077B/en active Active
- 2010-03-23 JP JP2011507099A patent/JP5930713B2/en active Active
- 2010-03-23 WO PCT/JP2010/054910 patent/WO2010113688A1/en active Application Filing
-
2012
- 2012-04-23 HK HK12104008.8A patent/HK1163509A1/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158081A (en) * | 1994-09-15 | 1997-08-27 | 普罗克特和甘保尔公司 | Oral compositions |
| EP0920857A2 (en) * | 1997-11-06 | 1999-06-09 | Dentaid, S.A. | Oral composition for the treatment of halitosis |
| CN1960696A (en) * | 2004-03-29 | 2007-05-09 | 高露洁-棕榄公司 | Improved dental whitening method |
| CN1993104A (en) * | 2004-06-02 | 2007-07-04 | 高露洁-棕榄公司 | Anti-staining antibacterial dentifrice |
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| Title |
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| JP平2-212413A 1990.08.23 |
| JP平4-128217A 1992.04.28 |
| JP昭57-171909A 1982.10.22 |
| JP特开2009-7292A 2009.01.15 |
| 权利要求9. |
| 第[0028]段第1行，第3-4行 |
| 裘炳毅.第五篇 口腔卫生制品.《化妆品化学与工艺技术大全（下册）》.中国轻工业出版社,1997,(第1版),第1360-1361页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5930713B2 (en) | 2016-06-08 |
| JPWO2010113688A1 (en) | 2012-10-11 |
| KR101649003B1 (en) | 2016-08-17 |
| HK1163509A1 (en) | 2012-09-14 |
| KR20110133573A (en) | 2011-12-13 |
| WO2010113688A1 (en) | 2010-10-07 |
| CN102365077A (en) | 2012-02-29 |
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