CN106999363B - Oral composition - Google Patents
Oral composition Download PDFInfo
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- CN106999363B CN106999363B CN201580068706.4A CN201580068706A CN106999363B CN 106999363 B CN106999363 B CN 106999363B CN 201580068706 A CN201580068706 A CN 201580068706A CN 106999363 B CN106999363 B CN 106999363B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Provided is an oral composition which can inhibit metallic taste or astringency caused by a water-soluble metal salt, and can impart excellent palatability and can be suitably used for inhibiting formation of dental plaque, the oral composition comprising: (A) 1 or 2 or more water-soluble metal salts selected from copper salts, zinc salts and tin salts, (B) benzyl alcohol, and (C) xylitol and/or erythritol, wherein the mass ratio of (A)/(B) is 0.04-10, and the mass ratio of (A)/(C) is 0.01-10.
Description
Technical Field
The present invention relates to an oral composition containing a water-soluble metal salt, which is capable of suppressing a metallic taste or a astringent feeling caused by the water-soluble metal salt, has excellent palatability (palatablity), and is suitable for suppressing the formation of dental plaque (tartar).
Background
Conventionally, water-soluble metal salts such as copper salts, zinc salts, and tin salts have been proposed as having an effect of inhibiting plaque formation, and there are proposed techniques for incorporating them into oral compositions (patent documents 1 to 3: PCT publication No. 2010/113688, Japanese patent laid-open Nos. 2007 and 126421, and 5 to 930).
However, the water-soluble metal salt has a problem that the astringent feeling during use is too strong and the metallic aftertaste after use is bad, and therefore, the oral composition containing the water-soluble metal salt has a disadvantage of poor palatability (patent document 2).
On the other hand, it is known that benzyl alcohol is mixed as a flavor component or preservative (preservative agent) in an oral composition, and that benzyl alcohol has an antibacterial activity (patent documents 4 to 7: Japanese patent application laid-open No. 2009-531414, Japanese patent application laid-open No. 2010-523551, Japanese patent application laid-open No. 2013-540813, and Japanese patent application laid-open No. 2013-32371).
Documents of the prior art
Patent document
PCT publication No. 2010/113688 (patent document 1)
[ patent document 2 ] Japanese patent laid-open No. 2007-126421
[ patent document 3 ] Japanese patent laid-open No. 5-930
[ patent document 4 ] Japanese patent application laid-open No. 2009-531414
[ patent document 5 ] Japanese patent application publication No. 2010-523551
[ patent document 6 ] Japanese patent Kokai publication 2013-540813
[ patent document 7 ] Japanese patent laid-open No. 2013-32371
Disclosure of Invention
[ problem to be solved by the invention ]
Accordingly, an object of the present invention is to suppress a metallic taste or a astringent feeling of an oral composition containing a water-soluble metal salt and to improve palatability.
The present invention has been made in view of the above circumstances, and an object thereof is to provide an oral composition containing a water-soluble metal salt, which suppresses metallic taste or a feeling of astringency caused by the water-soluble metal salt, imparts excellent palatability, and is suitably used for suppressing formation of dental plaque.
[ MEANS FOR solving PROBLEMS ] to solve the problems
The present inventors have conducted intensive studies to achieve the above object, and as a result, have found that: in the oral composition mixed with the water-soluble metal salt, the benzyl alcohol and the xylitol and/or the erythritol are combined and mixed according to a specific ratio, thereby producing a remarkable effect on the above-mentioned problems.
That is, it was found that an oral composition having excellent palatability and suppressed metallic taste or astringent feeling due to the water-soluble metal salt of component (a) can be obtained by containing 1 or 2 or more water-soluble metal salts selected from copper salts, zinc salts and tin salts, (B) benzyl alcohol, (C) xylitol and/or erythritol (erythrol) in a mass ratio of (a)/(B) of 0.04 to 10 and in a mass ratio of (a)/(C) of 0.01 to 10, and can be suitably used for suppressing formation of dental plaque, and the present invention has been finally completed.
More specifically, although water-soluble metal salts such as copper salts, zinc salts and tin salts have an effect of inhibiting plaque formation, they give a astringent feeling and a metallic taste, and benzyl alcohol also gives an astringent feeling, in the present invention, by appropriately combining a water-soluble metal salt of component (a) with a system of combining (B) benzyl alcohol and (C) xylitol and/or erythritol, it is unexpected that a sufficient metallic taste is inhibited while an effect of inhibiting plaque formation is maintained, and the astringent feeling is reduced, thereby providing excellent palatability. In this case, by using benzyl alcohol (B) in combination with the water-soluble metal salt of component (a) in the (a)/(B) ratio within the specific range, the metallic aftertaste after use is reduced, and the metallic aftertaste can be suppressed even after 5 minutes has passed after use, and further, by using xylitol (C) and/or erythritol in the sugar alcohol in combination with the water-soluble metal salt of component (a) in the (a) ratio within the specific range, the strong astringent feeling during use can be reduced, and the above-mentioned excellent action and effect can be remarkably imparted.
Further, based on patent documents 4 to 7, it cannot be predicted that: (B) when the ratio (A)/(B) and the ratio (A)/(C) are within specific ranges, the combination of the components (A) and (C) remarkably suppresses the metallic taste and the astringent feeling derived from the component (A).
In the present invention, it is particularly preferable that the component (a) is a water-soluble metal salt of 1 or 2 or more selected from copper gluconate, zinc citrate and tin fluoride.
Accordingly, the present invention provides an oral composition and a method for suppressing the metallic taste and astringent feeling of a water-soluble metal salt in the oral composition described below.
[ 1 ] an oral composition comprising:
(A) 1 or more than 2 water-soluble metal salts selected from copper salt, zinc salt and tin salt,
(B) benzyl alcohol, and
(C) xylitol and/or erythritol;
(A) the mass ratio of (v)/(B) is 0.04 to 10, and the mass ratio of (A)/(C) is 0.01 to 10.
[ 2 ] the oral composition according to [ 1 ], wherein the component (A) is 1 or 2 or more water-soluble metal salts selected from the group consisting of copper gluconate, copper citrate, zinc gluconate, zinc chloride, tin fluoride and tin chloride.
[ 3 ] the oral composition according to [ 1 ], wherein the component (A) is a water-soluble metal salt of 1 or 2 or more selected from copper gluconate, zinc citrate and tin fluoride.
[ 4 ] the oral composition according to [ 1 ], [ 2 ], or [ 3 ], which comprises: 0.01 to 3 mass% of component (B), and 0.01 to 20 mass% of component (C).
[ 5 ] the oral composition according to any one of [ 1 ] to [ 4 ], which comprises 0.01 to 2.6 mass% of the component (A).
[ 6 ] the oral composition according to any one of [ 1 ] to [ 5 ], which is formulated into a dentifrice.
[ 7 ] A method for suppressing the metallic taste and astringent feeling of a water-soluble metal salt of component (A) in an oral composition, which comprises mixing, in an oral composition containing 1 or 2 or more water-soluble metal salts selected from copper salts, zinc salts and tin salts:
(B) benzyl alcohol, and
(C) xylitol and/or erythritol, and/or xylitol and/or erythritol,
(A) the mass ratio of (v)/(B) is 0.04 to 10, and the mass ratio of (A)/(C) is 0.01 to 10.
ADVANTAGEOUS EFFECTS OF INVENTION
According to the present invention, there can be provided an oral composition containing a water-soluble metal salt, which is suppressed in metallic taste or astringency attributable to the water-soluble metal salt, has excellent palatability, and is suitable for use in suppressing plaque formation.
Detailed Description
The present invention will be described in more detail below. The oral composition of the present invention comprises: (A) 1 or 2 or more water-soluble metal salts selected from copper salts, zinc salts and tin salts, (B) benzyl alcohol, and (C) xylitol and/or erythritol, wherein the mass ratio of (A)/(B) and the mass ratio of (A)/(C) are respectively in specific ranges.
(A) The component (C) is a water-soluble metal salt selected from copper salts, zinc salts and tin salts, and examples thereof include: copper salts such as copper gluconate and copper citrate; zinc salts such as zinc citrate, zinc gluconate, and zinc chloride; tin salts such as tin fluoride and tin chloride, and particularly preferred are copper gluconate, zinc citrate and tin fluoride. These may be used alone in 1 kind, or in combination of 2 or more kinds in view of the effect. Preferred components (A) are copper salts and tin salts, and copper salts are more preferred.
(A) The amount of the water-soluble metal salt of component (a) is preferably 0.01 to 2.6% by mass of the total composition (hereinafter, the same), more preferably 0.02 to 2.6%. The more the amount is mixed, the higher the effect of inhibiting plaque formation, and 0.01% or more can impart a sufficient effect of inhibiting plaque formation. When the content is 2.6% or less, the astringent feeling and metallic taste can be satisfactorily suppressed.
In addition, within the range of the mixing amount of the component (A), the water-soluble metal salts may be used singly or in combination of 2 or more, but the mixing amount of each metal salt is preferably 0.01 to 1% by weight, 0.4 to 2% by weight, and 0.1 to 0.5% by weight, based on the total composition, of copper salt, zinc salt, and tin salt.
(B) The amount of benzyl alcohol to be mixed as the component (B) is preferably 0.01 to 3%, more preferably 0.02 to 3%, and still more preferably 0.02 to 1% of the total composition. When the amount is 0.01% or more, the metallic odor derived from the water-soluble metal salt can be sufficiently suppressed. When the content is 3% or less, the astringent feeling derived from benzyl alcohol can be suppressed, the astringent feeling during use can be suppressed, and the palatability can be maintained more appropriately.
(C) The component (b) is xylitol and/or erythritol, and xylitol or erythritol may be used, and from the viewpoint of exhibiting the effect, xylitol or erythritol may also be used.
(C) The amount of the component (a) to be mixed is preferably 0.01 to 20%, more preferably 0.02 to 13%, and still more preferably 0.05 to 5% of the total composition. When the content is 0.01% or more, the sense of astringency can be further improved. When the content is 20% or less, the metallic taste derived from the water-soluble metal salt can be sufficiently suppressed. When the amount exceeds 20%, the metallic taste derived from the water-soluble metal salt may be more strongly perceived due to the sweet taste derived from the component (C), and therefore 20% or less is preferable.
In the present invention, (A)/(B), which represents the ratio of the amounts of components (A) and (B) to be mixed, is 0.04 to 10, preferably 0.1 to 8, and more preferably 0.1 to 5 in terms of mass ratio. By combining the components (A) and (B) within the above range, the metallic taste and the astringent feeling can be suppressed, and the palatability can be improved. (A) If the amount of the salt is less than 0.04, the astringent taste derived from benzyl alcohol is strongly felt, and the palatability is poor, whereas if the amount is more than 10, the metallic taste derived from the water-soluble metal salt cannot be reduced, and the object of the present invention cannot be achieved.
In the present invention, (A)/(C) representing the ratio of the amounts of components (A) and (C) to be mixed is 0.01 to 10, preferably 0.02 to 5, in terms of mass ratio. By mixing the components (a) and (C) in combination within the above range, the metallic taste and the astringent feeling can be suppressed, and the palatability can be improved. If the amount is less than 0.01, the metallic taste derived from the water-soluble metal salt is further emphasized by the sweet taste derived from the component (C), and if the amount is more than 10, the astringent feeling cannot be reduced, and the object of the present invention cannot be achieved.
The oral composition of the present invention is particularly suitably formulated into a dentifrice such as toothpaste or liquid toothpaste. In addition to the above components, other known components may be mixed as necessary within a range not to impair the effects of the present invention. For example, in the toothpaste formulation, an abrasive, a thickener, a binder, a surfactant, and if necessary, a sweetener, a coloring agent, a preservative, a flavor, an active ingredient, and the like may be mixed. The amount to be mixed may be an ordinary amount within a range not impairing the effect of the present invention.
Examples of the polishing agent include: silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, and zirconium silicate, anhydrates of calcium hydrogen phosphate dihydrate and calcium hydrogen phosphate, calcium phosphate-based compounds such as monocalcium phosphate and tricalcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, synthetic resin-based abrasives, zeolite, alumina, and the like. The amount of the abrasive to be mixed is usually 2 to 40%, particularly 10 to 30%.
Examples of the thickener include polyhydric alcohols such as glycerin, propylene glycol and polyethylene glycol, sorbitol and the like. The amount of these thickeners is usually 5 to 50%, particularly 20 to 45%.
Examples of the binder include: cellulose derivatives such as sodium carboxymethylcellulose, gums (gum type) such as xanthan gum (xanthan gum), alginic acid derivatives such as sodium alginate, organic binders such as carrageenan (carrageenan), synthetic binders such as Carbopol (Carbopol) and Gantrez (Gantrez), and inorganic binders such as gelling silica, gelling aluminum silica, Veegum, and Laponite. The amount to be mixed is usually 0.1 to 10%, particularly 0.5 to 3%.
As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant may be mixed.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, N-acyl sarcosinates such as sodium N-lauroyl sarcosinate, and N-acyl glutamates.
Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hardened castor oil, polyoxyethylene higher alcohol ethers, and fatty acid alkanolamides.
As the cationic surfactant, an alkylammonium type, an alkylbenzylammonium salt or the like can be used, and as the amphoteric surfactant, a fatty acid amide propyl betaine, an acetic acid betaine type, an imidazoline type or the like can be used.
The amount of the surfactant to be mixed is 0.01 to 10%, particularly preferably 0.01 to 5%.
Examples of the sweetener include sodium saccharin, acesulfame K (acesulfame K), and sucralose (sucralose), and examples of the colorant include red No. 2, blue No. 1, and titanium oxide.
Examples of the preservative include parabens such as methyl paraben, benzoic acid or a salt thereof.
As the perfume, there may be used in combination: peppermint oil (peppermint oil), spearmint oil (spearmint oil), anise oil, eucalyptus oil, wintergreen oil, cinnamon oil (cassia oil), clove oil, thyme oil, sage oil, lemon oil (lemon oil), orange oil, peppermint oil (ハッカ oil), cardamom oil, coriander oil, mandarin oil (mandarin oil), lime oil (lime oil), lavender oil, rosemary oil, bay oil (laurel oil), chamomile oil (chamomile oil), caraway oil (caraway oil), marjoram oil (marjoram oil), bay oil (bay oil), lemongrass oil (origanum oil), pine needle oil, neroli oil (neroli oil), rose oil, jasmine oil, grapefruit oil (grapefruit oil), swort oil (sweet oil), rose oil (スウィーティー), rose oil (pepper oil), peppermint oil (peppermint oil), peppermint oil (clove oil, clove oil (スウィーティー), peppermint oil (peppermint oil, peppermint, Natural flavors such as orange blossom, or flavors obtained after processing (precutting, fractionating, liquid-liquid extracting, refining, powderizing, etc.) of these natural flavors, and menthol, carvone, anethole, eucalyptol, methyl salicylate, cinnamaldehyde, eugenol, 3-l-menthoxypropane-1, 2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, pulegone, carbitol acetate (carbitol acetate), anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenylglycerol, vanillin, undecalactone, hexanal, carbitol acetate, and the like, Examples of the flavoring agent include but are not limited to known flavoring agents used in oral compositions, such as monomeric flavors such as butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methylcyclopentadienyl ketone, furfural, trimethylpyrazine, ethyl lactate, and ethyl thioacetate, and further blend flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, cream flavor, milk flavor, fruit mix flavor, and tropical fruit flavor.
The amount to be mixed is not particularly limited, and it is preferable to use 0.000001 to 1% of the above-mentioned perfume raw material in the formulation composition. In addition, as the perfume for giving fragrance using the above perfume raw material, it is preferable to use 0.1 to 2% in the formulation composition.
As the active ingredient, known substances usually mixed in oral compositions can be mixed in an effective amount within a range not to impair the effect of the present invention, for example, bactericides such as triclosan (triclosan), isopropyl methylphenol, cetyl pyridinium chloride, benzethonium chloride (benzethonium chloride), antiinflammatory agents such as tranexamic acid (tranexamic aci d), allantoin, glycyrrhetinic acid, enzymes such as dextranase, sodium salts of fluorides such as sodium fluoride and sodium monofluorophosphate, aluminum lactate, arginine, condensed phosphoric acid (condensed phosphoric acid), plant extracts, and the like.
Examples
The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples,% "represents% by mass unless otherwise specified.
[ examples and comparative examples ]
Oral compositions (toothpastes) having compositions shown in tables 1 to 3 were prepared according to a conventional method and evaluated by the following method. The results are also shown in the table.
< evaluation method >
(1) Evaluation of after-use metallic aftertaste
0.5g of toothpaste was applied to a toothbrush (Clinica toothbrush 3 rows, hardness: ordinary), and after brushing teeth for 3 minutes, the teeth were rinsed with water, and metallic taste felt in the mouth after 5 minutes had passed was judged in the following 5 stages. The average points of 10 of the metal residues were evaluated according to the following criteria, and the metal residues after use were expressed as "excellent", "good", "Δ", and "x" in the table.
Criterion for determination
5: no metallic taste was felt
4: slightly metallic taste was felt
3: feeling a metallic smell
2: strongly felt the metallic taste
1: very strong sensation of metallic taste
Evaluation criteria
Very good: average point of 4.5 to 5.0 points
O: average point of 4.0 points or more and less than 4.5 points
And (delta): average point of 3.0 points or more and less than 4.0 points
X: average point of 1.0 point or more and less than 3.0 points
(2) Evaluation of sense of Convergence in use
A0.5 g toothpaste was applied to a toothbrush, and the mouth-astringency was judged in the following 5 stages. The average points of 10 items were evaluated according to the following criteria, and the convergence sensation during use is expressed as "excellent", "Δ", and "x" in the table.
Criterion for determination
5: no sense of convergence was felt
4: slightly feeling of convergence
3: feeling of convergence
2: the convergence sensation was strongly felt
1: the convergence feeling was very strongly felt
Evaluation criteria
Very good: average point of 4.5 to 5.0 points
O: 4.0 or more and less than 4.5 points on the average
And (delta): 3.0 points or more and less than 4.0 points on the average
X: less than 3.0 points at an average point of 1.0 point or more
The raw materials used are detailed below.
(A) Copper gluconate: preparation of copper gluconate from Kanto chemical Co., Ltd
Zinc citrate: zinc citrate made by Kanto chemical Co., Ltd
Tin fluoride: pure chemical (manufactured by Kabushiki Kaisha) tin fluoride
(B) Benzyl alcohol: pure chemical (manufactured by Kabushiki Kaisha) tin fluoride
(C) Xylitol: pure chemical xylitol (manufactured by Kabushiki Kaisha)
Erythritol: pure chemical (Kabushiki Kaisha) erythritol
[ TABLE 1 ]
[ TABLE 2 ]
[ TABLE 3 ]
As shown in table 3, when the (a)/(B) ratio or (a)/(C) ratio is not appropriate, the metal aftertaste or astringent feeling is felt and the palatability is poor even when the (B) and (C) components are mixed with the (a) component (comparative example), whereas the oral composition of the present invention (example) in which the (a), (B), and (C) components are mixed in combination in an appropriate range of the (a)/(B) ratio and the (a)/(C) ratio is suppressed and the palatability is excellent as shown in tables 1 and 2. As can be seen, the oral compositions of these examples are very suitable for imparting plaque formation-inhibiting effects.
Claims (5)
1. An oral composition comprising:
0.01 to 2.6 mass% of (A) 1 or 2 or more water-soluble metal salts selected from copper salts, zinc salts and tin salts based on the total composition,
0.01 to 3 mass% of (B) benzyl alcohol, and
0.01 to 20 mass% of (C) xylitol and/or erythritol;
(A) the mass ratio of (v)/(B) is 0.04 to 10, and the mass ratio of (A)/(C) is 0.01 to 10.
2. The oral composition according to claim 1, wherein the component (A) is 1 or 2 or more water-soluble metal salts selected from the group consisting of copper gluconate, copper citrate, zinc gluconate, zinc chloride, tin fluoride and tin chloride.
3. The oral composition according to claim 1, wherein the component (A) is a water-soluble metal salt of 1 or 2 or more selected from the group consisting of copper gluconate, zinc citrate and tin fluoride.
4. The oral composition of claim 1,2 or 3, formulated as a dentifrice.
5. A method for suppressing the metallic taste and astringent feeling of a water-soluble metal salt of component (A) in an oral composition, which comprises mixing 0.01 to 2.6 mass% of a water-soluble metal salt of 1 or 2 or more kinds selected from copper salts, zinc salts and tin salts with respect to the total composition:
0.01 to 3 mass% of (B) benzyl alcohol, and
0.01 to 20 mass% of (C) xylitol and/or erythritol,
(A) the mass ratio of (v)/(B) is 0.04 to 10, and the mass ratio of (A)/(C) is 0.01 to 10.
Applications Claiming Priority (3)
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JP2014251494 | 2014-12-12 | ||
JP2014-251494 | 2014-12-12 | ||
PCT/JP2015/084541 WO2016093279A1 (en) | 2014-12-12 | 2015-12-09 | Composition for use in oral cavity |
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CN106999363A CN106999363A (en) | 2017-08-01 |
CN106999363B true CN106999363B (en) | 2021-04-06 |
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JP (1) | JP6610561B2 (en) |
KR (1) | KR102497986B1 (en) |
CN (1) | CN106999363B (en) |
MY (1) | MY179102A (en) |
WO (1) | WO2016093279A1 (en) |
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JP7167713B2 (en) * | 2016-11-28 | 2022-11-09 | ライオン株式会社 | oral composition |
WO2019230707A1 (en) * | 2018-05-29 | 2019-12-05 | ライオン株式会社 | Composition for oral cavity |
WO2019230710A1 (en) | 2018-05-29 | 2019-12-05 | ライオン株式会社 | Composition for oral cavity |
WO2020264562A1 (en) * | 2019-06-28 | 2020-12-30 | The Procter & Gamble Company | Oral care compositions comprising tin ions |
AU2020303738A1 (en) | 2019-06-28 | 2021-12-16 | The Procter & Gamble Company | Dentifrice compositions comprising tin ions |
WO2024025387A1 (en) * | 2022-07-29 | 2024-02-01 | 주식회사 엘지생활건강 | Oral care composition and method for preparing oral care composition |
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WO2016093279A1 (en) | 2016-06-16 |
JP6610561B2 (en) | 2019-11-27 |
CN106999363A (en) | 2017-08-01 |
JPWO2016093279A1 (en) | 2017-09-21 |
KR20170094133A (en) | 2017-08-17 |
KR102497986B1 (en) | 2023-02-09 |
MY179102A (en) | 2020-10-28 |
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