WO2019230707A1

WO2019230707A1 - Composition for oral cavity

Info

Publication number: WO2019230707A1
Application number: PCT/JP2019/021053
Authority: WO
Inventors: 飯島　浩; 三四郎成松; 高橋　雅人
Original assignee: ライオン株式会社
Priority date: 2018-05-29
Filing date: 2019-05-28
Publication date: 2019-12-05
Also published as: CN111867550B; JPWO2019230707A1; JP7298601B2; KR20210014618A; CN111867550A

Abstract

Provided is an oral cavity composition that contains copper ions, that has an excellent oral cavity biofilm sterilization effect and an excellent effect of inhibiting occurrence of a bad breath component, and that is suitable for inhibiting bad breath. This composition for the oral cavity contains (A) 0.001-0.2 mass% of copper ions, (B) 0.01-1 mass% of a nonionic disinfectant, and (C) 0.1-2 mass% of one or more anionic surfactants selected from acyl taurines, acyl amino acids, and salts thereof. This composition for an oral cavity may further contain (D) 0.01-3 mass% of one or more selected from organic acids having not more than 10 carbon atoms and salts thereof.

Description

Oral composition

The present invention relates to a composition for oral cavity that contains copper ions, has an excellent effect of suppressing the generation of bad breath components as well as an oral biofilm sterilization effect, and is suitable for the suppression of bad breath.

Conventionally, various oral compositions in which a water-soluble copper compound is blended with an oral composition for the purpose of preventing bad breath have been proposed, focusing on the antibacterial action and deodorizing action of a water-soluble copper compound containing copper ions. No. 1 (Patent No. 2540892) proposes an oral composition in which a copper compound such as copper gluconate and a specific bactericide are used in combination, and an antibacterial effect and an excellent odor removal effect are excellent.
Further, as a technique using a water-soluble copper compound, Patent Document 2 (Japanese Patent Application Laid-Open No. 2011-105650) describes a gel-type oral composition that can be used by being applied to the oral cavity. It has been proposed that a biofilm inhibitory effect and a gingipain inhibitory effect are excellent by adding an agent, a surfactant and the like, and the retention in the oral cavity is enhanced, which is effective in improving periodontal disease. Patent Document 3 (Japanese Patent Application Laid-Open No. 2003-192555) shows that a dentifrice composition using a special abrasive (specific synthetic amorphous silicate) in combination with a copper compound has an excellent halitosis suppression effect even after long-term storage. Has proposed.
However, various factors may be involved in the generation of bad breath, and it is difficult to satisfactorily suppress bad breath, and the bad breath suppression effect on periodontal disease patients is not always sufficient.

By the way, pathogenic bacteria that cause periodontal disease are inhabited by forming a strong biofilm in the oral cavity, and nonionic fungicides such as isopropylmethylphenol are effective for osmotic sterilization of this biofilm. It is known (Patent Document 4; Japanese Patent Application Laid-Open No. 2011-98916), but it was not possible to satisfactorily suppress bad breath by simply sterilizing the biofilm.

Japanese Patent No. 2540892 JP 2011-105650 A JP 2003-192555 A JP 2011-98916 A

The present invention has been made in view of the above circumstances, and has an object to provide a composition for oral cavity that contains copper ions, is excellent in an oral biofilm sterilization effect and an effect of suppressing the generation of bad breath components, and is suitable for use in suppressing bad breath. And

As a result of intensive studies to achieve the above object, the present inventors have formulated a combination of a nonionic fungicide and a specific anionic surfactant into a specific amount of copper ions into the oral composition. It has been found that in addition to the biofilm sterilization effect, it has an excellent effect of suppressing the generation of bad breath components, particularly methyl mercaptan. That is, in the present invention, (A) 0.001 to 0.2% by mass of copper ion, (B) 0.01 to 1% by mass of nonionic fungicide, (C) acyltaurine, acylamino acid and salts thereof The composition for oral cavity containing 0.1 to 2% by mass of one or more anionic surfactants selected from the group is excellent in the bactericidal effect of oral biofilm and the effect of suppressing the generation of bad breath components, Even if it is formed, it is found that it suppresses the generation of halitosis components from halitosis-causing bacteria over a long period of time, has a good taste, and is particularly effective for the suppression or removal of halitosis. It came to.

More specifically, when the present inventors studied with the goal of taking care to prevent bad breath in patients suffering from periodontal disease in particular, the effect of suppressing bad breath by copper ions was not sufficient, and the composition for oral use was made of copper. The bad breath was not satisfactorily suppressed only by adding ions. Therefore, focusing on biofilms that tend to be more common among those suffering from periodontal disease, it is estimated that the bad breath component produced by the bad breath causing bacteria in the biofilm is the main cause, and bad breath components from the biofilm Further studies were carried out with the aim of suppressing the occurrence of odors. As a result, when the components (B) and (C) are combined in an appropriate amount with the component (A) and blended into an oral composition, particularly a dentifrice composition, the three members act synergistically and surprisingly Inhibition of the generation of halitosis components has been enhanced and this has resulted in the generation of halitosis components, in particular methyl mercaptan, over a long period of time, even when the bacteria that cause halitosis have formed biofilms, in addition to the biofilm bactericidal effect. It was possible to impart an excellent action and effect. Therefore, according to the present invention, it is possible to effectively suppress or remove bad breath of a person suffering from periodontal disease, which has been difficult to suppress only by sterilization of a biofilm.
In the present invention, the combination of the components (A), (B), and (C) was able to give the above-mentioned special effects, and as shown in the comparative examples described later, (A), ( In the absence of any of the components B) and (C), the effect of inhibiting the generation of methyl mercaptan was poor and the effect was inferior (Comparative Examples 1 to 5). On the other hand, even if the components (A) and (B) are blended and the anionic surfactant sodium lauryl sulfate is blended, if the component (C) is not blended, the effect of inhibiting the generation of methyl mercaptan was inferior. (Comparative Example 6).
In addition, although patent document 1 is the continuous suppression of the antibacterial and bad breath by a copper compound and a disinfectant, the effect with respect to a biofilm is not examined and is unknown. Patent document 2 is the improvement of the gingipaine inhibitory action of a water-soluble copper compound and the biofilm penetration bactericidal effect of a phenolic fungicide in a gel oral composition, and thereby suppression of periodontal disease. Patent document 3 is the improvement of the bad breath suppression effect of a copper compound by the special synthetic amorphous silicate as an abrasive | polishing agent of a dentifrice composition. On the other hand, the present invention is a specific bactericidal biofilm sterilization and suppression of the generation of bad breath components by a combination of the three components (A), (B) and (C). In the toothpaste composition, a particularly remarkable effect can be imparted.

Accordingly, the present invention provides the following oral composition.
[1]
(A) 0.001 to 0.2% by mass of copper ions,
(B) 0.01 to 1% by mass of a nonionic fungicide, and (C) 0.1 to 2 of one or more anionic surfactants selected from acyl taurine, acyl amino acids and salts thereof. mass%
The composition for oral cavity to contain.
[2]
(A) The composition for oral cavity according to [1], wherein the copper ion source is one or more water-soluble copper compounds selected from copper gluconate, copper citrate, copper sulfate and copper chloride.
[3]
(B) The oral composition according to [1] or [2], wherein the nonionic fungicide is isopropylmethylphenol.
[4]
The oral composition according to any one of [1] to [3], wherein the acyl taurine and the acyl amino acid each have an acyl group having 8 to 18 carbon atoms.
[5]
The oral composition according to any one of [1] to [4], wherein the component (C) is selected from acyl taurine and salts thereof.
[6]
(C) The composition for oral cavity as described in [5] whose component is lauroyl methyl taurine sodium.
[7]
(D) The oral composition according to any one of [1] to [6], further comprising 0.01 to 3% by mass of one or more selected from organic acids having 10 or less carbon atoms and salts thereof Stuff.
[8]
The oral composition according to any one of [1] to [7], which is a toothpaste composition containing a silica-based abrasive.
[9]
The oral composition according to any one of [1] to [8], which is used for suppressing bad breath and sterilizing oral biofilms.

According to the present invention, it is possible to provide a composition for oral cavity that contains copper ions and is excellent in the effect of suppressing the generation of bad breath components together with the bactericidal effect of oral biofilm and suitable for the suppression of bad breath. This composition for oral cavity can also be used effectively for suppressing or removing bad breath of a person suffering from periodontal disease.

The present invention will be described in further detail below. The composition for oral cavity of this invention contains (A) copper ion, (B) nonionic fungicide, and (C) specific anionic surfactant.
Here, “copper ion” means a copper ion of a copper compound dissolved in a liquid medium (water or the like) of the composition, and is not an insoluble copper compound existing in a solid state in the composition.

(A) Copper ion is a bad breath suppression or removal agent, and acts as a generation inhibitor of methyl mercaptan, a bad breath component.
It is preferable that the copper containing compound used as a copper ion source is a water-soluble copper compound. The water-soluble copper compound is a compound having a water solubility at 25 ° C. of 5 g / 100 mL or more, and preferably a water-soluble copper salt such as copper gluconate, copper citrate, copper sulfate, copper chloride, more preferably copper gluconate. , Copper citrate, copper sulfate, especially copper gluconate, copper citrate. These may be used alone or in combination of two or more.
(A) component can also use the copper ion derived from the solution which melt | dissolved the poorly water-soluble or insoluble copper compound whose solubility in water in 25 degreeC is less than 5 g / 100mL in another solvent as another aspect, The above solution can also be used as a source of ions. For example, copper ions obtained by dissolving water-insoluble copper oxide in an acidic aqueous solution such as dilute hydrochloric acid can also be used. In addition, copper of a copper-containing compound formed by dissolving a metal complex in the system and copper of a copper-containing compound solubilized using a surfactant can also be used as the copper ion of the present invention.

The blending amount of (A) copper ions is 0.001 to 0.2% (mass%, the same applies hereinafter) of the entire composition, preferably 0.005 to 0.15%, more preferably 0.01 to 0.1%. When it is 0.001% or more, a sufficient bad breath removing effect is exhibited and a methyl mercaptan generation suppressing effect is exhibited. If it exceeds 0.2%, the metallic taste of copper is enhanced, making it difficult to suppress, and the taste of the preparation becomes poor. In addition, the preparation stability after storage (no liquid separation, no discoloration) may be inferior.

(B) The nonionic bactericide has a biofilm bactericidal action and acts as a generation inhibitor of methyl mercaptan, which is a bad breath component.
The nonionic fungicide is preferably isopropylmethylphenol or triclosan, more preferably isopropylmethylphenol (3-methyl-4-isopropylphenol).
The blending amount of the (B) nonionic fungicide is 0.01 to 1%, preferably 0.05 to 0.5% of the whole composition. If it is less than 0.01%, a sufficient biofilm sterilizing effect and a methyl mercaptan generation suppressing effect are inferior. The upper limit amount is not particularly limited, but if it is 1% or less, it is sufficiently dissolved in the preparation, and if it exceeds 1%, the solubility is lowered and the action may be inferior.

Component (C) is one or more anionic surfactants selected from acyl taurine, acyl amino acids, and salts thereof. The component (C) acts as a generation inhibitor of methyl mercaptan, which is a bad breath component. Moreover, it contributes also to the improvement of the biofilm sterilization effect by (B) component. As the component (C), those selected from acyl taurine and salts thereof are particularly preferable from the viewpoint of the above-described effects.
The component (C) preferably has an acyl group having 8 to 18 carbon atoms, particularly 12 to 16 carbon atoms, and is selected from acyl taurine salts and acyl amino acid salts having the acyl group. Salts are preferred. Of these, lauroylmethyl taurine salt, lauroyl sarcosine salt, particularly lauroylmethyl taurine salt are preferable. These salts are alkali metal salts, alkaline earth metal salts, organic amine salts and the like, among which alkali metal salts, particularly sodium salts are preferred.

Examples of the acyl taurine salt include sodium lauroylmethyl taurate, myristoyl methyl taurine sodium, coconut oil fatty acid methyl taurine sodium and the like.
Examples of the acyl amino acid salt include sodium lauroyl sarcosine, sodium lauroyl glutamate, sodium lauroyl aspartate and the like.
Commercially available products can be used. Specifically, NIKKOL LMT (lauroyl methyl taurine sodium, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL MMT (myristoyl methyl taurine sodium, manufactured by Nikko Chemicals Co., Ltd.), Soypon SLP (lauroyl sarcosine) Sodium, manufactured by Kawaken Fine Chemical Co., Ltd.), Amisoft LS-11 (sodium lauroyl glutamate, manufactured by Ajinomoto Healthy Supply Co., Ltd.) and the like can be used.

The blending amount of component (C) is 0.1 to 2%, preferably 0.3 to 1.5% of the whole composition. If the blending amount is less than 0.1%, the effect of suppressing the generation of methyl mercaptan cannot be sufficiently obtained, and the biofilm sterilization effect tends to be low. When it exceeds 2%, the metallic taste of copper derived from the component (A) becomes strong, and the taste of the preparation is lowered.

In the present invention, anionic surfactants other than the above component (C) may be blended as long as the effects of the present invention are not hindered. In particular, alkyl sulfates such as sodium lauryl sulfate are not blended. (Blending amount 0%) is better, and when blending, the amount is preferably 0.5% or less, particularly 0.2% or less, particularly 0.1% or less of the whole composition.

The oral composition of the present invention preferably further contains (D) an organic acid having 10 or less carbon atoms or a salt thereof. When (D) component is mix | blended, the metal taste by copper derived from (A) component will improve, and the taste of a formulation will be more excellent.
The organic acid has 10 or less carbon atoms, preferably 4 to 6 carbon atoms, and tricarboxylic acid, dicarboxylic acid or a salt thereof having the carbon number can be used, and the salt is an alkali metal salt. Among them, hydroxy acid such as citric acid, tartaric acid, malic acid and salts thereof are preferable. These may be used alone or in combination of two or more.

The blending amount of component (D) is preferably 0.01 to 3%, more preferably 0.1 to 2% of the entire composition. Within this range, the taste improving effect is more excellent, and a sufficient methyl mercaptan generation suppressing effect is exhibited.

The oral composition of the present invention is particularly suitable as a dentifrice composition such as toothpaste, liquid dentifrice, and toothpaste, especially as a toothpaste composition. It can mix | blend as needed in the range which does not prevent the effect of invention. Specifically, abrasives, wetting agents, binders, surfactants other than anionic surfactants, and if necessary, sweeteners, colorants, preservatives, fragrances, compounds serving as copper ion sources, and nonionic sterilization Active ingredients other than the agent can be blended.

As the abrasive, a general abrasive for oral cavity can be used. For example, silica-based abrasives such as silicic anhydride such as precipitated silica and pyrogenic silica, aluminosilicate, zirconosilicate, titanium-binding silica, dicalcium phosphate dihydrate or anhydrous, monobasic calcium phosphate, Examples thereof include calcium phosphate-based abrasives such as tertiary calcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, and synthetic resin-based abrasives, and general silica-based abrasives for dentifrices are suitable. . The blending amount of these abrasives is usually 2 to 40%, particularly 10 to 30%.

Examples of the wetting agent include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as glycerin and propylene glycol. The blending amount of the wetting agent is usually 5 to 50%, particularly 10 to 40%.

As the binder, an organic binder or an inorganic binder can be used. Examples of the organic binder include cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, and hydroxyethylcellulose, gums such as xanthan gum, alginic acid derivatives such as sodium alginate, carrageenan, polyvinyl alcohol, and sodium polyacrylate. Examples of the inorganic binder include gelling silica and gelling aluminum silica.
The amount of binder is usually 0.1 to 10%, particularly 0.2 to 8%, and the amount of organic binder is 0.1 to 5%, particularly 0.5 to 3%. The blending amount of the inorganic binder is preferably 0.1 to 8%, particularly 0.5 to 5%.

As the surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be arbitrarily blended. Specifically, nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and the like. Examples include oxyethylene fatty acid esters, polyoxyethylene higher alcohol ethers such as polyoxyethylene stearyl ether, and fatty acid alkanolamides such as lauric acid diethanolamide. Examples of the cationic surfactant include alkylammonium types such as distearylmethylammonium chloride and alkylbenzylammonium salts. Examples of the amphoteric surfactant include alkyl betaines, betaine acetate types such as alkyldimethylaminoacetic acid betaines and fatty acid amidopropyl betaines, betaine types such as alkylimidazolinium betaines, and imidazoline types. The blending amount of these surfactants is preferably 0 to 10%, particularly 0.01 to 5%. The nonionic surfactant may be blended in an amount of 0.01% or less, or 0% without blending.

Sweeteners include sodium saccharin and the like, and colorants include blue No. 1, yellow No. 4, and titanium dioxide. Examples of the preservative include paraoxybenzoic acid esters such as methyl paraoxybenzoate, benzoic acid, and salts thereof.

Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil , Sardine oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and other natural fragrances, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder flavor Perfume, menthol, carvone Anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentan-3- Carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, Butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethylthioacetate In addition, single flavors such as strawberry flavor, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can use combining the well-known fragrance | flavor raw material used for a composition.
The blending amount of the fragrance material is preferably 0.000001 to 1%, and the blending amount of the fragrance material using the fragrance material is preferably 0.1 to 2%.

Active ingredients include cationic fungicides such as cetylpyridinium chloride and benzalkonium chloride, anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, allantoin, enzymes such as dextranase, sodium fluoride, sodium monofluorophosphate, etc. Fluorine-containing compounds, vitamins such as ascorbic acid and tocopherol acetate, and plant extracts such as dipotassium glycyrrhizinate, potassium nitrate, aluminum lactate, sodium chloride and thyme. The above-mentioned arbitrary active ingredient can be blended in an effective amount as long as the effects of the present invention are not hindered.

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in the table.

(1) Evaluation method of biofilm bactericidal effect As oral bacteria, Actinomyces viscosus ATCC 43146, Fusobacterium nucleatum ATCC10953, Porphyromonas gingivalium 27 ) And 1 mg / L vitamin K (manufactured by Wako Pure Chemical Industries, Ltd.) and Todd Hevit broth (manufactured by Becton and Dickinson) culture solution [THBHM]. Veillonella parvula ATCC17745 was cultured using Todd Hewitt broth (Becton and Dickinson) culture solution [THBL] containing 1.26% sodium lactate (Sigma). The culture was anaerobic culture overnight at 37 ° C. (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen). After culturing, the bacterial solution was collected by centrifugation (8,000 g × 10 min). Each bacterium collected by centrifugation was resuspended in a basal medium mucin culture solution (BMM) ^{* 1} .
A hydroxyapatite (HA) plate (made by Asahi Optical Industry Co., Ltd.) having a diameter of 7 mm and a thickness of 3.5 mm treated with human unstimulated saliva filtered through a 0.45 μm filter is used as a carrier for producing a model biofilm. , 24 holes multiplate (manufactured by Sumitomo Bakelite Co., Ltd.). The above 4 strains prepared by BMM to 1 × 10 ⁷ cfu / mL (cfu: colony forming units) were inoculated, and the anaerobic condition (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) was 37 ° C. By continuously culturing for 6 days, a model biofilm mixed with 4 bacterial species was formed on the surface of the HA plate.
After forming the biofilm, 0.5 mL of the centrifugal supernatant obtained by diluting the toothpaste composition of each example 3 times with distilled water as a test preparation was applied to the biofilm-attached HA plate from which the culture solution was removed for 3 minutes. Treatment (control is the same treatment using phosphate buffered saline (PBS, manufactured by Wako Pure Chemical Industries, Ltd.)), washed 6 times with 1 mL of PBS, transferred to 4 mL of physiological saline, The biofilm was dispersed with an ultrasonic homogenizer. This biofilm dispersion was serially diluted 10-fold with physiological saline, smeared on a blood agar medium at 50 μL, anaerobically cultured for 1 week, and the number of colonies that had grown was counted.
The number of colonies was compared with the control (PBS treatment), and the biofilm bactericidal effect was evaluated according to the following criteria.
Evaluation criteria A: The number of colonies is less than 1/500 B: The number of colonies is 1/500 or more and less than 1/100 x: The number of colonies is 1/100 or more

* 1; BMM composition (expressed in mass in 1 L)
Proteose peptone (Becton and Dickinson):
4g / L
Tryptone (Becton and Dickinson):
2g / L
Yeast extract (Becton and Dickinson):
2g / L
Mucin (Sigma): 5g / L
Hemin (manufactured by Sigma): 2.5 mg / L
Vitamin K (Wako Pure Chemical Industries, Ltd.): 0.5mg / L
KCl (Wako Pure Chemical Industries, Ltd.): 1g / L
Cysteine (Wako Pure Chemical Industries, Ltd.): 0.2g / L
Distilled water: remaining (up to a volume of 1 L, autoclaved at 120 ° C. for 20 minutes)

(2) Evaluation method of methyl mercaptan generation inhibitory effect After forming a model biofilm in the same manner as in (1), 0.5 mL of a centrifugal supernatant obtained by diluting the toothpaste composition of each example three times with distilled water as a test preparation Was treated for 3 minutes (control was similarly treated using PBS), washed with PBS, transferred to a glass bottle, and sealed by adding a methionine-containing PBS solution. After incubating at 37 ° C., the concentration of methyl mercaptan (MeSH) in the gas phase after 3 hours was measured by gas chromatography.
The methyl mercaptan concentration was compared with the control (PBS treatment), and the methyl mercaptan generation inhibitory effect was evaluated according to the following criteria.
Evaluation criteria ◎: Methyl mercaptan concentration is less than 1/10 ○: Methyl mercaptan concentration is 1/10 or more and less than 1/4 Δ: Methyl mercaptan concentration is 1/4 or more and less than 1/2 ×: Methyl mercaptan concentration is 1/2 or more

(3) Evaluation method of taste (bitterness, lack of metal taste) of the preparation The feeling of use (taste) was evaluated by five subjects. 1 g of the test preparation was placed on a toothbrush (clinica advantage toothbrush, 4-row compact normal type, manufactured by Lion Corporation), and brushing was performed for 3 minutes. The taste during brushing was judged according to the following criteria. The average score of 5 people was calculated | required and the taste (bitterness, lack of metal taste) of a formulation was evaluated by the following evaluation criteria.
Rating criteria 5: Very good 4: Good 3: Not good 2: Not good 1: Very bad Evaluation criteria ◎: Average score of 5 people is 4 or more ○: Average score of 5 people is 3.5 △: Less than 4 points △: Average score of 5 people is 3 or more and less than 3.5 points ×: Average score of 5 people is less than 3 points

*: Amount of copper in insoluble powder (solid).

Claims

(A) 0.001 to 0.2% by mass of copper ions,
(B) 0.01 to 1% by mass of a nonionic fungicide, and (C) 0.1 to 2 of one or more anionic surfactants selected from acyl taurine, acyl amino acids and salts thereof. mass%
The composition for oral cavity to contain.
The oral composition according to claim 1, wherein (A) the copper ion source is one or more water-soluble copper compounds selected from copper gluconate, copper citrate, copper sulfate and copper chloride.
(B) The composition for oral cavity according to claim 1 or 2, wherein the nonionic fungicide is isopropylmethylphenol.
The oral composition according to any one of claims 1 to 3, wherein the acyl taurine and the acyl amino acid each have an acyl group having 8 to 18 carbon atoms.
The composition for oral cavity according to any one of claims 1 to 4, wherein the component (C) is selected from acyl taurine and salts thereof.
The composition for oral cavity according to claim 5, wherein component (C) is sodium lauroylmethyltaurine.
The oral composition according to any one of claims 1 to 6, further comprising (D) 0.01 to 3% by mass of one or more selected from organic acids having 10 or less carbon atoms and salts thereof. .
The oral composition according to any one of claims 1 to 7, which is a toothpaste composition containing a silica-based abrasive.
The composition for oral cavity according to any one of claims 1 to 8, which is used for suppressing bad breath and sterilizing oral biofilms.