JPH0925221A - Fur-removing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a fur-removing agent capable of chemically removing fur which is a main causative site of the occurrence of foul breath, accordingly suppressing the foul breath for a long time and further being formulated into various preparations by compounding a specific enzyme with a specific surfactant. SOLUTION: This fur-removing agent is obtained by compounding an enzyme selected from N-acetylmuramidase, mutanolysin, lysozyme, levanase and lipase with one or more than one kind of surfactant selected from a betaine-type, a N-acetyltaurine-type, a methylglycosylester-type, a dialkylsulfosuccinic acid- type and a monoacylphosphoric acid-type surfactant. A compounding amount of the enzyme is preferably 0.001-5wt.% based on the total weight of the agent. A compounding ratio of the surfactant is 0.01-5wt.% based on the total weight of the agent. The fur-removing agent can be formulated into various preparations such as an oral composition and a food. Examples of the preparation include a dentifrice, a mouthwash, a troche, a chewing gum, a gargle, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD [0001] The present invention is capable of chemically removing tongue coating, which is the main cause of halitosis, to suppress halitosis for a long period of time, and to prepare oral dosage compositions and the like in various dosage forms. The present invention relates to a tongue coating remover capable of removing.

[0002]

2. Description of the Related Art
As a means of removing bad breath, bactericidal agents, deodorants, masking agents, etc. are mainly used in the technical development, and the following proposals have been made, but oral products containing these active ingredients have been proposed. Halitosis removal and preventive effects are
There were many things that lacked sustainability and were insufficient. (1) Dextranase + anionic activator + nonionic activator (toothpaste: JP-A-48-56836) (2) Dextranase + anionic activator + carboxylic acid type amphoteric activator (for oral cavity Composition: JP-A-48-5683
No. 6) (3) Dextranase + lytic enzyme (composition for oral cavity: JP-A-50-58243) (4) Dextranase + perfume + nonionic activator (oral cleanser: JP-A-61) No. 176518) (5) Dextranase + higher aliphatic alcohol (composition for oral cavity: JP 62-4221 A) (6) Dextranase + C ₁₄ -C ₁₆ sarcosinate (composition for oral cavity: special (Kaisho No. 62-195320) (7) Dextranase + ether nonionic activator (transparent liquid oral composition: Japanese Patent Laid-Open No. 63-8326) (8) Dextranase + nonionic activator ( (Transparent liquid oral composition: JP-A-63-10713) (9) Lytic enzyme + fatty acid alkalol amide or sucrose fatty acid ester (oral composition: JP-A-50-1544)
No. 41) (10) N-acetylmuramidase + alkalizing agent + nonionic activator (oral composition: JP-A-2-25081
No. 6) (11) Amylase + imidazoline-based amphoteric active agent (dentifrice: JP-A-58-69808) (12) Mutanase + sarcosinate + sucrose fatty acid ester (oral composition: JP-A-59-152315) (13) Lysozyme + nonionic activator + polyhydric alcohol (lysopasta production method: JP-A-44-40058) (14) Lysozyme + anionic activator (lysozyme-blended dentifrice composition: JP-A-52-90638) (Gazette) (15) Lysozyme + sodium fluoride (toothpaste composition:
(Japanese Patent Laid-Open No. 52-54037)

On the other hand, the occurrence of halitosis in the oral cavity was thought to be caused by plaque, periodontal pockets, saliva, tongue coating, etc., but recently, the importance of tongue coating has been pointed out.

From these things, tongue coating has attracted attention as a source of halitosis, and it is desired to develop a preparation capable of maintaining a sufficient halitosis preventing effect for a long time by reducing the tongue coating.

The present invention has been made in view of the above circumstances, and an object thereof is to provide a tongue coating remover capable of effectively removing tongue coating, which is a main cause of bad breath, to suppress halitosis for a long time. To do.

[0006]

Means for Solving the Problems and Modes for Carrying Out the Invention As a result of extensive studies conducted by the present inventor to achieve the above object, an enzyme selected from N-acetylmuramidase, mutanolysin, lysozyme, revanase and lipase was selected. , Betaine type, N-acyl taurine type, methyl glucosyl ester type, dialkyl sulfosuccinic acid type and monoacyl phosphoric acid type surfactants are used in combination with one or more types to cause the main cause of bad breath. It was discovered that a tongue coating removing agent capable of chemically effectively removing a certain tongue coating and suppressing bad breath for a long period of time can be obtained, and thus accomplished the present invention.

The present invention will be described in more detail below. The agent for removing tongue coating of the present invention is an enzyme selected from N-acetylmuramidase, mutanolysin, lysozyme, revanase and lipase and betaine type, N-acyltaurine type, methyl type. One or more selected from glucosyl ester type, dialkyl sulfosuccinic acid type and monoacyl phosphoric acid type surfactants are used in combination.

[0008] Here, the above-mentioned enzyme content is 0.
001-5% (wt%, the same applies below), especially 0.01-1
% Range is preferred. Although the amount of enzyme is limited by the titer, for example, lysozyme chloride (0.1 unit /
mg) is preferably used in the range of 0.001 to 1%. If the enzyme content is less than 0.001%, a satisfactory tongue coating removal effect may not be obtained, and if it exceeds 5%, no further effect may be obtained.

Examples of the above-mentioned surfactants include betaine-type trimethylglycine, lauryldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazole. As an N-acyl taurine type, such as nium betaine, 2-alkyl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine, 2-alkyl-N-sodium carboxymethyl-N-carboxymethyloxyethyl imidazolinium betaine N-cocoyl methyl taurine sodium, N-lauroyl methyl taurine sodium, N-
Α-methyl-D-glucopyranoside-6 as methyl glucosyl ester type, such as myristoyl methyl taurine sodium and N-palmitoyl methyl taurine sodium
-O-acylate, α-methyl-D-glucopyranoside-6-O-laurate, α-methyl-D-glucopyranoside-6-O-myristate, α-methyl-D-glucopyranoside-6-O-palmitate, etc., dialkyl As the sulfosuccinic acid type, sodium di (2-ethylhexyl) sulfosuccinate, sodium di (2-methylhexyl) sulfosuccinate, and the like, and as the monoacylphosphoric acid type, laurylphosphoric acid, sodium laurylphosphate, polyoxyethylenelauryletherphosphoric acid, monoacylphosphate- 2-
Examples thereof include triethanolamine salt.

In the present invention, one kind of the above-mentioned surfactants may be used alone or two or more kinds may be used in combination, and the blending amount thereof is 0.01 to 5%, especially 0.1 to 5%.
A range of 2% is preferred. If the blending amount is less than 0.01%, a satisfactory effect may not be obtained, and if it exceeds 5%, bitterness may occur or the stability of the enzyme may be adversely affected.

The tongue coating remover of the present invention can be prepared into various preparations such as oral compositions and foods. Specifically, toothpaste such as toothpaste, liquid toothpaste, moisturizing toothpaste, mouthwash, troche and the like. , Chewing gum, mouthwash and the like.

In this case, in addition to the above essential components, various optional components depending on the dosage form can be blended. For example, in dentifrice, an abrasive, a binder, a thickener, a surfactant other than the above, A sweetener, an antiseptic, a coloring agent, various active ingredients other than the above-mentioned enzymes, and the like can be added, and these ingredients can be mixed with water to produce the composition. Here, as the abrasive, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, and zirconosilicate, dicalcium phosphate dihydrate and anhydrate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, Magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, synthetic resin-based abrasives, etc. are preferably used (usually 10 to 50%).

As the thickener, glycerin, sorbit, propylene glycol, polyethylene glycol,
Examples of binders such as xylit, maltite, and lactit include sodium carboxymethyl cellulose, hydroxyethyl cellulose, carrageenan, sodium alginate, xanthan gum, carbopol, guar gum, montmorillonite, gelatin (usually 5 to 70%),
As the surface active agent, an anionic surface active agent, a nonionic surface active agent, or a zwitterionic surface active agent can be used. Examples of anionic surfactants include sodium alkylsulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-lauroyl sarcosinate, N-
N-acyl sarcosinate sodium such as sodium myristoyl sarcosinate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N
-N-acyl glutamate such as sodium palmitoyl glutamate, N-methyl-N-acyl alanine sodium, sodium α-olefin sulfonate, etc., as nonionic surfactants, sucrose fatty acid ester, maltose fatty acid ester, lactose fatty acid ester, etc. Sugar alcohol fatty acid ester such as sugar fatty acid ester, maltitol fatty acid ester, lactitol fatty acid ester, polyoxyethylene sorbitan monolaurate,
Polyoxyethylene sorbitan monostearate and other polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil and other polyoxyethylene fatty acid ester, lauric acid mono- or diethanolamide, myristic acid mono- or diethanolamide and other fatty acid diethanolamide, sorbitan Examples of zwitterionic surfactants such as fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, N-lauroyldiaminoethylglycine, N-myristyldiaminoethyl N such as glycine
-Alkyldiaminoethylglycine (usually 0.1 to 5%), preservatives such as paraoxybenzoate and sodium benzoate, and various active ingredients such as sodium fluoride, potassium fluoride, ammonium fluoride. , Stannous fluoride, fluorides such as sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salts and sodium salts of orthophosphoric acid, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizinic acid and Salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, α-bisabolol, isopropylmethylphenol, chlorohexidine salts,
Cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, dextranase, mutanase, amylase , Methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone,
Epidihydrocholesterine, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, soft cane extract, oak extract, clove,
Extracts such as rosemary, sardine, safflower, etc., such as 1-menthol, carvone, anethole,
Examples of colorants such as terpenes such as limonene or derivatives thereof include Blue No. 1, Yellow No. 4, titanium dioxide, and alumina oxide. In addition, the compounding amount of these components can be a normal amount within a range that does not hinder the effects of the present invention.

[0014]

The tongue coating remover of the present invention can chemically remove tongue coating, which is the main cause of halitosis, which can suppress halitosis for a long period of time, and further reduce the halitosis. However, since the reduction of tongue coating can be visually perceived, it is possible to visually recognize the reduction of halitosis by removing tongue coating. Oral compositions, foods, etc. Can be prepared and used.

[0015]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%. [Experimental Example] Using the agents shown in Tables 1 and 2, the amount of tongue coating was evaluated by the following method. The results are shown in Tables 1 and 2. In vitro tongue coating amount evaluation system : Streptococcus salivarius, a tongue coating matrix-forming bacterium separated from human tongue coating in 5 ml of THB medium containing 1% sucrose
40 μl of the pre-cultured solution was inoculated and subjected to anaerobic conditions (80% N ₂ :
18% at 37 ° C. under 10% H ₂ : 10% CO ₂ , the same applies below.
Main culture was performed for an hour. Centrifuge this (1 at 3500 rpm)
After 0 minutes), the supernatant was removed, and 2.5 ml of the drug sample shown in Tables 1 and 2 (0.05 M phosphate buffer, pH 7.
0) was added. After stirring, this was reacted at 37 ° C. for 30 minutes, treated at 100 ° C. for 5 minutes, and then centrifuged again. The supernatant was removed, and the precipitate was suspended in 5 ml of the above buffer solution, stirred, and then centrifuged again. The supernatant was removed, and the precipitate was added to 5 ml of 0.5 NNa.
After suspending in OH, OD ₅₅₀ was measured. The in vitro tongue coating amount was shown as a relative value with the control OD ₅₅₀ as 100.

[0016]

[Table 1]

[0017]

[Table 2]

[Example 1] Toothpaste Aluminum hydroxide 43% Sorbit 20 Sodium carboxymethyl cellulose 2 Sodium lauryl sulfate 0.5 Lauroyl sarcosine sodium 0.3 Sodium lauryl phosphate 0.2 Perfume 1 Sodium saccharin 0.1 Lysozyme chloride 0. 2 Sodium fluoride 0.02 Water Residual 100.0%

[Example 2] Toothpaste Aluminum hydroxide 43% Solbit 20 Sodium carboxymethyl cellulose 2 Sodium lauryl sulfate 0.5 Lauroyl sarcosine sodium 0.3 α-Methyl-D-glucopyranoside-6-O-acylate 0.2 Perfume 1 Saccharin sodium 0.1 Mutanolysin 0.05 Sodium fluoride 0.02 Water Residual 100.0%

[Example 3] Toothpaste Aluminum hydroxide 40% Solbit 22 Sodium carboxymethyl cellulose 2 Sodium lauryl sulfate 0.5 Sodium lauroyl sarcosine 0.3 Di (2-ethylhexyl) sulfosuccinate 0.2 Perfume 1 Sodium saccharin 0. 1 Levanase 0.05 Sodium fluoride 0.02 Water Residual 100.0%

[Example 4] Toothpaste Dicalcium phosphate 43% Solbit 20 Propylene glycol 2 Carboxymethyl cellulose sodium 0.3 Carrageenan 0.8 Sodium lauryl sulfate 0.5 Lauroyl sarcosine sodium 0.3 Di (2-ethylhexyl) sulfosuccinate Sodium 0.2 Perfume 1 Saccharin sodium 0.1 Lysozyme chloride 0.3 Sodium monofluorophosphate 0.1 Water Residual 100.0%

Example 5 Toothpaste Dibasic calcium phosphate 43% Solbit 20 Propylene glycol 2 Carboxymethyl cellulose sodium 0.3 Carrageenan 0.8 Sodium lauryl sulphate 0.5 Lauroyl sarcosine sodium 0.3 Sodium monoacyl phosphate 0.2 Perfume 1 Saccharin sodium 0.1 Mutanolysin 0.1 Water Total 100.0%

Example 6 Dibasic calcium phosphate dihydrate 40% Solbit 10 Sodium carboxymethyl cellulose 1 Sodium myristyl sulfate 0.5 Lauroyl sarcosine sodium 0.3 N-Cocoylmethyl taurine sodium 0.3 N-Acetylmuramidase 0.01 Perfume 1 Saccharin sodium 0.1 Stannous fluoride 0.05 Water Residual 100.0%

[Example 7] Liquid toothpaste Sodium polyacrylate 50% Glycerin 30 Fragrance 0.9 Sodium saccharin 0.1 Copper gluconate 0.1 Lysozyme chloride 0.1 α-Methyl-D-glucopyranoside-6-O-acylate 0.2 Sodium lauroyl sarcosinate 0.2 Water Residual total 100.0%

[Example 8] Liquid toothpaste Sodium polyacrylate 50% Glycerin 30 Perfume 0.9 Sodium saccharin 0.1 Copper gluconate 0.1 N-Acetylmuramidase 0.1 Di (2-ethylhexyl) sodium sulfosuccinate 0 .2 Sodium lauroyl sarcosinate 0.2 water Total 100.0%

[Example 9] Liquid toothpaste Sodium polyacrylate 50% Glycerin 30 Perfume 0.9 Sodium saccharin 0.1 Copper gluconate 0.05 Levanase 0.02 α-Methyl-D-glucopyranoside-6-O-acylate 0 .2 Sodium lauroyl sarcosinate 0.2 water Total 100.0%

[Example 10] Liquid toothpaste Sodium polyacrylate 50% Glycerin 30 Perfume 0.9 Sodium saccharin 0.1 Copper gluconate 0.1 Lipase 0.1 N-Lauroylmethyltaurine sodium 0.2 Sodium lauryl sulfate 0. 1 Sodium lauroyl sarcosinate 0.1 Water Residual 100.0%

Example 11 Mouthwash Ethanol 20% Sorbit 10 Sodium saccharin 0.08 Copper gluconate 0.05 Chlorhexidine hydrochloride 0.005 Lysozyme chloride 0.05 Lauryldiethanolamide 0.2 Lauroylsarcosine sodium 0.3 Trimethylglycine 0.1 Fragrance 0.9 Water Residual 100.0%

[Example 12] Mouthwash Ethanol 20% Sorbit 10 Sodium saccharin 0.08 Copper gluconate 0.05 Chlorhexidine hydrochloride 0.005 Lysozyme chloride 0.15 Lauryldiethanolamide 0.2 Lauroylsarcosine sodium 0.3 α- Methyl-D-glucopyranoside-6-O-acylate 0.2 Perfume 0.9 Water Residual 100.0%

Example 13 Mouthwash Ethanol 20% Sorbit 10 Sodium saccharin 0.08 Copper gluconate 0.05 Chlorhexidine hydrochloride 0.005 Lysozyme chloride 0.1 Lauryldiethanolamide 0.2 Lauroyl sarcosine sodium 0.3 Trimethylglycine 0.1 Fragrance 0.9 Water Residual 100.0%

[Example 14] Mouthwash Ethanol 20% Sorbit 10 Sodium saccharin 0.08 Copper gluconate 0.05 Chlorhexidine gluconate 0.005 N-Acetylmuramidase 0.01 Trimethylglycine 0.2 Lauroyl sarcosine sodium 0.3 Fragrance 0.9 Water Residual 100.0%

Example 15 Mouthwash Ethanol 20% Sorbit 10 Sodium saccharin 0.08 Copper gluconate 0.02 Chlorhexidine hydrochloride 0.005 Levanase 0.02 Trimethylglycine 0.2 Lauroyl sarcosine sodium 0.3 Perfume 0.9 Water balance 100.0%

Example 16 Mouthwash Ethanol 20% Sorbit 10 Sodium saccharin 0.08 Copper gluconate 0.05 Chlorhexidine hydrochloride 0.005 Lipase 0.02 Lauryldiethanolamide 0.2 Lauroylsarcosine sodium 0.3 Trimethylglycine 0 .1 Fragrance 0.9 Water Total 100.0%

Example 17 Mouthwash Ethanol 15% Sorbit 10 Sodium saccharin 0.04 Zinc chloride 0.05 N-Lauroylmethyltaurine sodium 0.2 Mutanolysin 0.02 Lauryldiethanolamide 0.1 Perfume 0.9 Water Residual balance 100.0%

[Example 18] Lozenge gum arabic 6.0% Glucose 70.0 Gelatin 3.0 Sodium myristoyl sarcosinate 0.1 α-Methyl-D-glucopyranoside-6-O-acylate 0.2 Lysozyme chloride 0. 5 Fragrance 0.2 Water Total 100.0%

Example 19 Lozenge Gum Arabic 6.0% Glucose 70.0 Gelatin 3.0 Sodium lauroyl sarcosinate 0.1 Trimethylglycine 0.1 N-Acetylmuramidase 0.02 Lipase 0.02 Perfume 0.0. 2 Water balance 100.0%

[Example 20] Lozenge gum arabic 6.0% Glucose 70.0 Gelatin 3.0 Sodium lauroyl sarcosinate 0.1 Trimethylglycine 0.1 N-Acetylmuramidase 0.02 Mutanolysin 0.1 Perfume 0.1. 2 Water balance 100.0%

[Example 21] Lozenge gum arabic 6.0% Glucose 70.0 Gelatin 3.0 Sodium lauroyl sarcosinate 0.1 Trimethylglycine 0.1 Levanase 0.02 Mutanolysin 0.02 Perfume 0.2 Water balance 100.0%

[Example 22] Chewing gum Gum base 40.0% Calcium carbonate 2.0 Water candy 15.0 Powdered sugar 35.0 Perfume 0.5 Mutanolysin 0.05 α-methyl-D-glucopyranoside-6-O-acylate 0.1 Water balance 100.0%

[Example 23] Chewing gum Gum base 40.0% Calcium carbonate 2.0 Water candy 15.0 Powdered sugar 35.0 Perfume 0.5 Lysozyme chloride 0.3 Trimethylglycine 0.1 Water Residual 100.0%

[Example 24] Chewing gum Gum base 40.0% Calcium carbonate 2.0 Water candy 15.0 Powdered sugar 35.0 Fragrance 0.5 Lipase 0.02 N-acetylmuramidase 0.01 Trimethylglycine 0.1 Water balance 100.0%

[Example 25] Chewing gum Gum base 40.0% Calcium carbonate 2.0 Water candy 15.0 Powdered sugar 35.0 Perfume 0.5 Lipase 0.02 Revanase 0.1 Trimethylglycine 0.1 Water Residual 100 0.0%

Claims (1)

[Claims] 1. An enzyme selected from N-acetylmuramidase, mutanolysin, lysozyme, revanase and lipase, and a betaine type, N-acyl taurine type, methyl glucosyl ester type, dialkyl sulfosuccinic acid type and monoacyl phosphate type surfactant. A tongue coating remover characterized by being used in combination with one or more selected from the group consisting of: