JP7298601B2 - oral composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to an oral cavity composition that contains copper ions, is excellent in the effect of suppressing the generation of halitosis components as well as the effect of sterilizing oral biofilms, and is suitable for suppressing halitosis.

Conventionally, focusing on the antibacterial action and deodorizing action of a water-soluble copper compound containing copper ions, various oral compositions containing a water-soluble copper compound added to oral compositions for the purpose of preventing bad breath have been proposed. 1 (Japanese Patent No. 2540892) proposes an oral cavity composition that uses a copper compound such as copper gluconate in combination with a specific bactericidal agent, and has an excellent antibacterial effect and a long lasting bad breath removing effect.
In addition, as a technique using a water-soluble copper compound, Patent Document 2 (Japanese Patent Application Laid-Open No. 2011-105650) discloses a gel-like oral composition that can be applied and used in the oral cavity, a water-soluble copper compound, and a phenolic sterilizer. By blending agents, surfactants, etc., it is proposed that the biofilm inhibitory effect and gingipain inhibitory effect are excellent, the retention in the oral cavity is enhanced, and it is effective in improving periodontal disease. Patent Document 3 (Japanese Patent Application Laid-Open No. 2003-192555) describes that a dentifrice composition in which a special abrasive (specific synthetic amorphous silicate) is used in combination with a copper compound has an excellent bad breath suppressing effect even after long-term storage. is proposing.
However, since various factors are involved in the development of halitosis in a complex manner, it is difficult to satisfactorily suppress halitosis.

By the way, pathogenic bacteria that cause periodontal disease live in the oral cavity forming a strong biofilm, and nonionic bactericides such as isopropylmethylphenol are effective in penetrating and sterilizing this biofilm. Although it is known (Patent Document 4; Japanese Patent Application Laid-Open No. 2011-98916), bad breath could not be suppressed satisfactorily just by sterilizing biofilms.

Japanese Patent No. 2540892 JP 2011-105650 A JP 2003-192555 A JP 2011-98916 A

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral composition that contains copper ions, is excellent in the effect of suppressing the generation of halitosis components as well as the effect of sterilizing oral biofilms, and is suitable for suppressing halitosis. and

The present inventors have made intensive studies to achieve the above objects, and found that when a specific amount of copper ions, a nonionic bactericide and a specific anionic surfactant are combined and blended into an oral composition, the oral cavity It was found that in addition to the biofilm sterilization effect, an excellent effect of suppressing the generation of bad breath components, especially methyl mercaptan, is exhibited. That is, in the present invention, (A) 0.001 to 0.2% by mass of copper ion, (B) 0.01 to 1% by mass of nonionic fungicide, (C) acyl taurine, acyl amino acid and salts thereof An oral composition containing 0.1 to 2% by mass of one or more anionic surfactants selected from is excellent in the effect of suppressing the generation of halitosis components as well as the bactericidal effect of oral biofilms, and biofilms Even if it is formed, it suppresses the generation of halitosis components from halitosis-causing bacteria for a long time, has a good taste, and has found that it is particularly effective for suppressing or removing halitosis, and made the present invention. reached.

More specifically, the present inventors conducted a study with the goal of preventing bad breath in patients suffering from periodontal disease, and found that the effect of copper ions in suppressing bad breath was not sufficient. Bad breath was not satisfactorily suppressed only by adding ions. Therefore, we focused on biofilms, which tend to be common in patients with periodontal disease, and presumed that the main cause was the components of halitosis produced by the bacteria that cause halitosis in the biofilms. Further studies were carried out with the aim of suppressing the occurrence of As a result, when component (A) is combined with components (B) and (C) in appropriate amounts and blended into an oral composition, particularly a dentifrice composition, the three components act synergistically, unexpectedly The effect of suppressing the generation of halitosis components is enhanced, and as a result, along with the biofilm sterilization effect, the generation of halitosis components, especially methyl mercaptan, occurs over a long period of time even if halitosis-causing bacteria form biofilms and inhabit. It was possible to impart an excellent effect of suppressing Therefore, according to the present invention, it is possible to effectively suppress or eliminate bad breath in patients suffering from periodontal disease, which has been difficult to suppress only by biofilm sterilization.
In the present invention, the combination of the components (A), (B) and (C) was able to provide the above-mentioned special effects. When one of the components B) and (C) was lacking, the methyl mercaptan formation inhibitory effect was poor and the effect was inferior (Comparative Examples 1 to 5). On the other hand, even if the components (A) and (B) were blended and the anionic surfactant sodium lauryl sulfate was further blended, if the component (C) was not blended, the methyl mercaptan generation inhibitory effect was inferior. (Comparative Example 6).
In addition, Patent Document 1 describes antibacterial properties and continuous suppression of bad breath by a copper compound and a disinfectant, but the effect on biofilms has not been investigated and is unknown. Patent Document 2 is an improvement in the gingipain inhibitory effect of a water-soluble copper compound and the biofilm permeation sterilization effect of a phenolic fungicide in a gel-like oral composition, thereby suppressing periodontal disease. Patent document 3 is an improvement of the bad breath suppressing effect of a copper compound by using a special synthetic amorphous silicate as an abrasive for a dentifrice composition. In contrast to these, the present invention is a specific oral biofilm sterilization and suppression of halitosis components by a combination of the three components (A), (B) and (C), and oral compositions, particularly In the toothpaste composition, it was possible to impart particularly remarkable effects.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) 0.001 to 0.2% by mass of copper ions,
(B) 0.01 to 1% by mass of a nonionic fungicide, and (C) 0.1 to 2 of one or more anionic surfactants selected from acyl taurine, acylamino acids and salts thereof mass%
Oral composition containing.
[2]
(A) The oral composition according to [1], wherein the copper ion source is one or more water-soluble copper compounds selected from copper gluconate, copper citrate, copper sulfate and copper chloride.
[3]
(B) The oral cavity composition according to [1] or [2], wherein the nonionic disinfectant is isopropylmethylphenol.
[4]
The oral composition according to any one of [1] to [3], wherein the acyl taurine and the acyl amino acid each have an acyl group of 8 to 18 carbon atoms.
[5]
The oral composition according to any one of [1] to [4], wherein component (C) is selected from acyl taurine and salts thereof.
[6]
(C) The oral composition according to [5], wherein the component is sodium lauroylmethyltaurate.
[7]
The oral cavity composition according to any one of [1] to [6], further containing (D) 0.01 to 3% by mass of one or more selected from organic acids having 10 or less carbon atoms and salts thereof. thing.
[8]
The oral composition according to any one of [1] to [7], which is a toothpaste composition containing a silica-based abrasive.
[9]
The oral cavity composition according to any one of [1] to [8], which is for bad breath suppression and oral biofilm sterilization.

According to the present invention, it is possible to provide an oral composition that contains copper ions, is excellent in the effect of suppressing the generation of halitosis components as well as the effect of sterilizing oral biofilms, and is suitable for suppressing halitosis. This oral composition can also be effectively used to suppress or eliminate bad breath in patients suffering from periodontal disease.

The present invention will be described in further detail below. The oral composition of the present invention contains (A) copper ions, (B) a nonionic germicide, and (C) a specific anionic surfactant.
As used herein, "copper ion" means the copper ion of a copper compound that is dissolved in the liquid medium (such as water) of the composition, and not the insoluble copper compound present in the composition in solid form.

(A) Copper ion is an agent for suppressing or removing bad breath, and acts as an agent for suppressing generation of methyl mercaptan, which is a bad breath component.
The copper-containing compound that serves as the copper ion source is preferably a water-soluble copper compound. The water-soluble copper compound is a compound having a water solubility of 5 g/100 mL or more at 25° C., and is preferably a water-soluble copper salt such as copper gluconate, copper citrate, copper sulfate, or copper chloride, more preferably copper gluconate. , copper citrate, copper sulfate, especially copper gluconate, copper citrate. These may be used singly or in combination of two or more.
As another aspect, the component (A) is a copper ion derived from a solution of a poorly water-soluble or insoluble copper compound with a water solubility of less than 5 g / 100 mL at 25 ° C. dissolved in another solvent. The above solution can also be used as a source of ions and formulated. For example, copper ions obtained by dissolving water-insoluble copper oxide in an acidic aqueous solution such as dilute hydrochloric acid can also be used. In addition, copper in a copper-containing compound formed by forming a metal complex and dissolved in the system, and copper in a copper-containing compound solubilized using a surfactant can be used as the copper ion of the present invention.

(A) The content of copper ions is 0.001 to 0.2% (% by mass, the same shall apply hereinafter) of the total composition, preferably 0.005 to 0.15%, more preferably 0.01 to 0.1%. When it is 0.001% or more, sufficient bad breath removing effect is exhibited and methyl mercaptan generation suppressing effect is exhibited. If it exceeds 0.2%, the metallic taste of copper is enhanced and difficult to suppress, resulting in a bad taste of the preparation. In addition, the formulation stability after storage (no liquid separation, no discoloration) may be inferior.

(B) The nonionic fungicide exhibits a biofilm sterilization effect and acts as an inhibitor of generation of methyl mercaptan, which is a bad breath component.
The nonionic fungicide is preferably isopropylmethylphenol, triclosan, more preferably isopropylmethylphenol (3-methyl-4-isopropylphenol).
The amount of (B) nonionic fungicide is 0.01 to 1%, preferably 0.05 to 0.5%, of the total composition. If it is less than 0.01%, sufficient biofilm sterilization effect and methyl mercaptan generation suppression effect are inferior. The upper limit of the amount is not particularly limited, but if it is 1% or less, it will be sufficiently dissolved in the formulation, and if it exceeds 1%, the solubility may decrease and the action may be inferior.

Component (C) is one or more anionic surfactants selected from acyl taurine, acyl amino acids and salts thereof. The component (C) acts as an inhibitor of generation of methyl mercaptan, which is a bad breath component. Moreover, it also contributes to the improvement of the biofilm bactericidal action by the component (B). As the component (C), those selected from acyl taurine and salts thereof are particularly preferable from the viewpoint of the above effects.
Component (C) preferably has an acyl group with 8 to 18 carbon atoms, particularly 12 to 16 carbon atoms, and is selected from acyl taurine salts and acyl amino acid salts having the acyl group. Salt is preferred. Among them, lauroyl methyl taurate, lauroyl sarcosine, and particularly lauroyl methyl taurate are preferred. These salts are alkali metal salts, alkaline earth metal salts, organic amine salts, etc. Among them, alkali metal salts, particularly sodium salts are preferred.

Examples of acyl taurine salts include sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, and sodium methyl taurate of coconut oil fatty acid.
Examples of acyl amino acid salts include sodium lauroyl sarcosinate, sodium lauroyl glutamate, sodium lauroyl aspartate and the like.
Commercially available products can be used, specifically, NIKKOL LMT (sodium lauroyl methyl taurate, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL MMT (sodium myristoyl methyl taurate, manufactured by Nikko Chemicals Co., Ltd.), Soypon SLP (lauroyl sarcosine) Sodium, manufactured by Kawaken Fine Chemicals Co., Ltd.), Amisoft LS-11 (sodium lauroyl glutamate, manufactured by Ajinomoto Healthy Supply Co., Ltd.), and the like can be used.

The content of component (C) is 0.1-2%, preferably 0.3-1.5%, of the total composition. If the compounding amount is less than 0.1%, the effect of inhibiting generation of methyl mercaptan cannot be sufficiently obtained, and the effect of biofilm sterilization tends to decrease. If it exceeds 2%, the copper derived from the component (A) has a strong metallic taste, and the taste of the preparation deteriorates.

In the present invention, anionic surfactants other than the above component (C) may be blended as long as they do not interfere with the effects of the present invention, but alkyl sulfates such as sodium lauryl sulfate are not particularly blended. (0% compounded amount) is better, and when compounded, the amount is preferably 0.5% or less, particularly 0.2% or less, and especially 0.1% or less based on the total composition.

The oral composition of the present invention preferably further contains (D) an organic acid having 10 or less carbon atoms or a salt thereof. When the component (D) is blended, the metallic taste due to the copper derived from the component (A) is improved and the taste of the formulation is more excellent.
The organic acid has 10 or less carbon atoms, preferably 4 to 6 carbon atoms, and tricarboxylic acids, dicarboxylic acids, and salts thereof having the above carbon atoms can be used, and the salts are alkali metal salts. Among them, hydroxy acids such as citric acid, tartaric acid, malic acid, and salts thereof are preferred. These may be used singly or in combination of two or more.

The content of component (D) is preferably 0.01 to 3%, more preferably 0.1 to 2%, of the total composition. Within this range, the effect of improving the taste is more excellent, and a sufficient effect of suppressing the generation of methyl mercaptan is exhibited.

The oral composition of the present invention is particularly suitable as a dentifrice composition such as a toothpaste, a liquid dentifrice, and a wet dentifrice, especially as a dentifrice composition. It can be blended according to need within a range that does not interfere with the effects of the invention. Specifically, abrasives, wetting agents, binding agents, surfactants other than anionic surfactants, sweeteners, coloring agents, preservatives, fragrances, compounds that serve as a source of copper ions, and nonionic sterilization if necessary. Active ingredients other than the agent can be blended.

Abrasives that are commonly used for the oral cavity can be used. For example, silicic anhydride such as precipitated silica and igneous silica, silica-based abrasives such as aluminosilicate, zirconosilicate and titanium-bonded silica, dicalcium phosphate dihydrate or anhydrate, monocalcium phosphate, Calcium phosphate-based abrasives such as tribasic calcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, and synthetic resin-based abrasives can be mentioned, and silica-based abrasives generally used for dentifrices are suitable. . The blending amount of these abrasives is usually 2 to 40%, particularly 10 to 30%.

Wetting agents include sugar alcohols such as sorbitol and xylite, and polyhydric alcohols such as glycerin and propylene glycol. The amount of wetting agent is usually 5-50%, especially 10-40%.

As the binder, an organic binder or an inorganic binder can be used. Examples of organic binders include cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, and hydroxyethylcellulose, gums such as xanthan gum, alginic acid derivatives such as sodium alginate, carrageenan, polyvinyl alcohol, and sodium polyacrylate. Examples of inorganic binders include gelling silica and gelling aluminum silica.
The amount of the binder is usually 0.1-10%, especially 0.2-8%, and the amount of the organic binder is 0.1-5%, especially 0.5-3%. The content of the inorganic binder is often 0.1 to 8%, preferably 0.5 to 5%.

A nonionic surfactant, a cationic surfactant, or an amphoteric surfactant can be arbitrarily blended as the surfactant. Specifically, nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oils and the like. Examples include oxyethylene fatty acid esters, polyoxyethylene higher alcohol ethers such as polyoxyethylene stearyl ether, and fatty acid alkanolamides such as lauric acid diethanolamide. Examples of cationic surfactants include alkylammonium types such as distearylmethylammonium chloride and alkylbenzylammonium salts. Amphoteric surfactants include alkylbetaines, betaine acetate types such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyl betaine, betaine types such as alkylimidazolinium betaine, and imidazoline types. The blending amount of these surfactants is preferably 0 to 10%, particularly 0.01 to 5%. The nonionic surfactant may be blended in an amount of 0.01% or less, or not blended at 0%.

Examples of sweetening agents include sodium saccharin, and examples of coloring agents include Blue No. 1, Yellow No. 4, titanium dioxide and the like. Preservatives include paraoxybenzoic acid esters such as methyl parahydroxybenzoate, benzoic acid, and salts thereof.

Peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime. Oil, Lavender Oil, Rosemary Oil, Laurel Oil, Chamomile Oil, Caraway Oil, Marjoram Oil, Bay Oil, Lemongrass Oil, Origanum Oil, Pine Needle Oil, Neroli Oil, Rose Oil, Jasmine Oil, Grapefruit Oil, Sweetie Oil , Yuzu Oil, Iris Concrete, Absolute Peppermint, Absolute Rose, Orange Flower, etc., and processing of these natural flavors (pre-reservoir cut, post-reservoir cut, fractional distillation, liquid-liquid extraction, essence formation, powder perfume ), and menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone , menthyl acetate, N-substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl Phenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate, etc., strawberry flavor, apple flavor, banana flavor , pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, mixed fruit flavor, and tropical fruit flavor. can.
The blending amount of the above perfume material is preferably 0.000001 to 1%, and the blending amount of the perfume for perfuming using the above perfume material is preferably 0.1 to 2%.

Active ingredients include cationic fungicides such as cetylpyridinium chloride and benzalkonium chloride, anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, and allantoin, enzymes such as dextranase, sodium fluoride, and sodium monofluorophosphate. vitamins such as ascorbic acid and tocopherol acetate, and plant extracts such as dipotassium glycyrrhizinate, potassium nitrate, aluminum lactate, sodium chloride and thyme. Any of the above active ingredients can be incorporated in an effective amount within a range that does not interfere with the effects of the present invention.

EXAMPLES The present invention will be specifically described below by showing examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are also shown in the table.

(1) Evaluation method of biofilm bactericidal effect As oral bacteria, Actinomyces viscosus ATCC43146, Fusobacterium nucleatum ATCC10953, Porphyromonas gingivalis ATCC33277 , 5 mg/L hemin (Sigma (manufactured by Wako Pure Chemical Industries, Ltd.) and 1 mg/L of vitamin K (manufactured by Wako Pure Chemical Industries, Ltd.). Veillonella parvula ATCC17745 was cultured using Toddhewitt broth (Becton and Dickinson) broth [THBL] containing 1.26% sodium lactate (Sigma). The culturing was carried out overnight at 37° C. with anaerobic culture (80 vol % nitrogen, 10 vol % carbon dioxide, 10 vol % hydrogen). After culturing, the bacterial solution was collected by centrifugation (8,000 g×10 min). Each bacterium collected by centrifugation was resuspended in basal medium mucin medium (BMM) ^*1 .
A hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) with a diameter of 7 mm and a thickness of 3.5 mm was treated with unstimulated human saliva filtered through a 0.45 μm filter, and used as a carrier for model biofilm production. , was placed on the bottom of a 24-well multiplate (manufactured by Sumitomo Bakelite Co., Ltd.). To this, the above 4 strains prepared to 1 × 10 ⁷ cfu / mL (cfu: colony forming units) with BMM were inoculated, 37 ° C., under anaerobic conditions (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) It was continuously cultured for 6 days to form a model biofilm of a mixture of 4 bacterial species on the surface of the HA plate.
After biofilm formation, 0.5 mL of the centrifugal supernatant obtained by diluting the toothpaste composition of each example 3-fold with distilled water as a test formulation was applied to the biofilm-adhered HA plate from which the culture medium was removed, for 3 minutes. Treatment (control was treated in the same way using phosphate buffered saline (PBS, manufactured by Wako Pure Chemical Industries, Ltd.)), washed 6 times with 1 mL of PBS, transferred to 4 mL of physiological saline, The biofilm was dispersed with an ultrasonic homogenizer. This biofilm dispersion was serially diluted 10-fold with physiological saline, 50 μL of each was smeared on a blood agar medium, anaerobic culture was performed for 1 week, and the number of grown colonies was counted.
The number of colonies was compared with the control (PBS treatment), and the biofilm bactericidal effect was evaluated according to the following criteria.
Evaluation criteria ◎: The number of colonies is less than 1/500 ○: The number of colonies is 1/500 or more and less than 1/100 ×: The number of colonies is 1/100 or more

* 1; Composition of BMM (indicated by mass in 1 L)
Proteose peptone (manufactured by Becton and Dickinson):
4g/L
Tryptone (manufactured by Becton and Dickinson):
2g/L
Yeast extract (manufactured by Becton and Dickinson):
2g/L
Mucin (manufactured by Sigma): 5 g / L
Hemin (manufactured by Sigma): 2.5 mg/L
Vitamin K (manufactured by Wako Pure Chemical Industries, Ltd.): 0.5 mg / L
KCl (manufactured by Wako Pure Chemical Industries, Ltd.): 1 g / L
Cysteine (manufactured by Wako Pure Chemical Industries, Ltd.): 0.2 g / L
Distilled water: Remainder (filled up to 1 L and autoclaved at 120°C for 20 minutes)

(2) Evaluation method of methyl mercaptan generation inhibitory effect After forming a model biofilm in the same manner as in (1), 0.5 mL of centrifugal supernatant obtained by diluting the toothpaste composition of each example 3 times with distilled water as a test formulation. for 3 minutes (controls were treated in the same way using PBS), washed with PBS, transferred to a glass bottle, added with a methionine-containing PBS solution, and sealed. After 3 hours of incubation at 37° C., the amount of methyl mercaptan (MeSH) in the gas phase was measured by gas chromatography to determine its concentration.
The methyl mercaptan concentration was compared with the control (PBS-treated), and the methyl mercaptan generation inhibitory effect was evaluated according to the following criteria.
Evaluation criteria ◎: Methyl mercaptan concentration is less than 1/10 ○: Methyl mercaptan concentration is 1/10 or more and less than 1/4 △: Methyl mercaptan concentration is 1/4 or more and less than 1/2 ×: Methyl mercaptan concentration is 1/2 or more

(3) Method for evaluating taste of formulation (absence of bitterness and metallic taste) Five subjects evaluated usability (taste). 1 g of the test formulation was placed on a toothbrush (Clinica Advantage Toothbrush, 4-row compact regular type, manufactured by Lion Corporation) and brushed for 3 minutes. The taste during toothbrushing was judged according to the following rating criteria. The average score of 5 people was obtained, and the taste of the preparation (absence of bitterness and metallic taste) was evaluated according to the following evaluation criteria.
Rating criteria 5: Very good 4: Good 3: Neither good nor bad 2: Not good 1: Very bad Evaluation criteria ◎: Average score of 5 people is 4 points or more ○: Average score of 5 people is 3.5 3 points or more and less than 4 points △: Average score of 5 people is 3 points or more and less than 3.5 points ×: Average score of 5 people is less than 3 points

＊：不溶粉末（固形物）中の銅量。

*: Amount of copper in insoluble powder (solid matter).

Claims (9)

(A) 0.005 to 0.1 % by mass of copper ions,
(B) 0.01 to 1% by mass of isopropylmethylphenol , and
(C) 0.3 to 1.5 % by mass of one or more anionic surfactants selected from acyl taurine and salts thereof
Oral composition containing. 2. The oral composition according to claim 1, wherein (A) the copper ion source is one or more water-soluble copper compounds selected from copper gluconate, copper citrate, copper sulfate and copper chloride. 3. The oral composition according to claim 1 , wherein component (C) is one or more anionic surfactants selected from acyl taurine having an acyl group of 8 to 18 carbon atoms and salts thereof . 4. The oral composition according to claim 3 , wherein component (C) is sodium lauroylmethyltaurate. 5. The oral composition according to any one of claims 1 to 4 , further comprising (D) one or more selected from organic acids having 10 or less carbon atoms and salts thereof in an amount of 0.01 to 3% by mass. . 6. The oral composition according to claim 5, wherein component (D) is one or more selected from hydroxy acids having 10 or less carbon atoms and salts thereof. (A) 0.005 to 0.1% by mass of copper ions,
(B) 0.01 to 1% by mass of isopropylmethylphenol,
(C') 0.3 to 1.5% by mass of one or more anionic surfactants selected from acylamino acids and salts thereof, and
(D') 0.01 to 3% by mass of one or more selected from hydroxy acids having 10 or less carbon atoms and salts thereof
and a copper ion source comprising one or more water-soluble copper compounds selected from copper gluconate, copper citrate, copper sulfate and copper chloride. The oral composition according to any one of claims 1 to 7, which is a toothpaste composition containing a silica-based abrasive. The oral composition according to any one of claims 1 to 8, which is used for suppressing bad breath and sterilizing oral biofilms.