JP2017007991A - Composition for oral cavity and method for improving bactericidal activity of hinokitiol in the composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a silica-containing composition for oral cavity which has improved bactericidal activity of hinokitiol and gives a moderate brushing feeling and is excellent in bactericidal effect of pathogenic bacteria in oral cavity, and to provide a method for improving bactericidal activity of hinokitiol in the composition for oral cavity.SOLUTION: The present invention relates to the composition for oral cavity, in which (C) 0.1 to 2 mass% of ascorbic acid phosphate or a salt thereof is formulated with the composition for oral cavity comprising (A) 5 to 40 mass% of silica and (B) 0.005 to 0.2 mass% of hinokitiol composition, and a method for improving bactericidal activity of hinokitiol in the composition for oral cavity in which the component (C) is formulated with the composition for oral cavity comprising the component (A) and the component (B).SELECTED DRAWING: None

Description

  The present invention relates to a silica-containing composition for oral cavity that improves the sterilizing power of hinokitiol, provides an appropriate feeling of brushing, and is excellent in the sterilizing effect of oral pathogenic bacteria.

  The cause of oral diseases such as periodontal disease is considered to be caused by various bacteria in the oral plaque, and periodontal disease, which is a typical oral disease, is obligatory such as P. gingivalis. It is an infection caused by bacteria, mainly anaerobic gram-negative bacilli. For this reason, since it is effective for the prevention or treatment of oral diseases to keep the number of pathogenic bacteria at a low level, various bactericides are used for oral compositions.

  Hinokitiol is often used in oral compositions such as dentifrices as a component derived from natural products having antibacterial and bactericidal effects on pathogenic bacteria in the oral cavity. However, hinokitiol has a drawback in that its antibacterial and bactericidal activity decreases when it is blended into an oral composition.

Conventionally, as a means for improving the antibacterial / bactericidal activity of hinokitiol in oral compositions, techniques using carboxylic acid type surfactants, edetic acid or salts thereof have been proposed (Patent Documents 1 to 4). In these, it was difficult to satisfactorily express the antibacterial and bactericidal activity derived from hinokitiol.
Furthermore, Patent Document 5 proposes a technique in which edetate is used and stabilized with an oral composition while maintaining the antibacterial activity of hinokitiol.

  On the other hand, various types of silica are used in the oral composition as an abrasive, a binder, and the like. In particular, a dentifrice generally contains abrasive silica and gives a feeling of brushing along with the ability to remove plaque.

JP 63-2111217 A JP 63-211118 A JP-A-4-198121 JP 2002-20253 A JP 2010-150155 A Japanese Patent Laid-Open No. 11-12142

  However, the sterilizing power of hinokitiol cannot be expressed satisfactorily in the silica-containing oral composition, and therefore, a new technique for improving the sterilizing power has been desired.

  The present invention has been made in view of the above circumstances, and provides a silica-containing composition for oral cavity that improves the sterilizing power of hinokitiol, gives an appropriate feeling of cleanliness, and is excellent in the sterilizing effect of oral pathogenic bacteria. For the purpose.

  As a result of intensive studies to achieve the above-mentioned object, the present inventor obtained an oral composition containing (A) 5 to 40% by mass of silica and (B) 0.005 to 0.2% by mass of hinokitiol. , (C) When 0.1 to 2% by mass of ascorbic acid phosphate ester or a salt thereof is added, the bactericidal power of hinokitiol is improved, and an appropriate bactericidal feeling is given and the bactericidal effect of oral pathogenic bacteria is excellent, In addition, it was found that the taste and good taste can be imparted by suppressing the taste and astringency.

  That is, when hinokitiol is blended with silica such as abrasive silica in the composition for oral cavity, there arises a problem that the bactericidal power of hinokitiol decreases, but in the present invention, in the combined system of (A) and (B) components, Surprisingly, the ascorbic acid phosphate ester (C) or its salt acts specifically to improve the bactericidal activity of hinokitiol, and pathogenic bacteria in the oral cavity, especially Porphyromonas gingivalis, a causative agent of periodontal disease (P. gingivalis) A high bactericidal power that can sterilize the bacterium at a sterilization rate of 60% or more is expressed, thereby achieving both an appropriate wiping effect derived from silica and a high bactericidal effect derived from hinokitiol. A working effect can be imparted. In this case, the silica of component (A) is (A-1) abrasive silica and / or (A-2) thickened silica, particularly (A-1) abrasive silica or (A-1) polishing. It is preferable that it is a functional silica and (A-2) thickening silica.

In addition, although the Example described as a composition for oral cavity which contains hinokitiol and edetate in patent document 5 and is excellent in antibacterial activity contains silicic anhydride in the composition, its content is as small as 4% by mass, In the first place, Patent Document 5 shows that the antibacterial activity of hinokitiol is improved by edetate. In Comparative Examples 2 and 3 containing no edetate, the stability of hinokitiol is inferior and the antibacterial activity is low.
Patent Document 6 discloses a composition for oral cavity that is excellent in preventing and improving gingivitis, comprising an antiplasmin agent and ascorbic acid and / or a derivative thereof in combination and an antibacterial agent. The toothpaste contains silica gel, hinokitiol and calcium ascorbate phosphate, but the amount of silica gel is as small as 2.0% by weight, and 50.0% by weight of aluminum hydroxide is blended as an abrasive.

Therefore, this invention provides the bactericidal power improvement method of the hinokitiol in the following oral cavity composition and oral cavity composition.
[1]
(A) 5 to 40% by mass of silica and (B) 0.005 to 0.2% by mass of hinokitiol are mixed with an oral composition containing 0.1% (C) ascorbic acid phosphate or a salt thereof. A composition for oral cavity characterized by containing ˜2% by mass.
[2]
The composition for oral cavity according to [1], wherein the component (A) is (A-1) abrasive silica and / or (A-2) thickened silica.
[3]
The composition for oral cavity according to [1], wherein the component (A) is (A-1) abrasive silica, or (A-1) abrasive silica and (A-2) thickened silica.
[4]
[2] or [3], wherein the component (A-1) is an abrasive silica having a median diameter of 5 to 40 μm, and the component (A-2) is a thickening silica having a liquid absorption of 2 to 3 ml / g. Oral composition.
[5]
(A-1) The composition for oral cavity as described in [3] or [4] whose compounding quantity of a component is 5-30 mass% and whose compounding quantity of (A-2) component is 0-10 mass%.
[6]
(C) The composition for oral cavity according to any one of [1] to [5], wherein the ascorbic acid phosphate or a salt thereof is a magnesium salt or a sodium salt of ascorbic acid phosphate.
[7]
(A) 5 to 40% by mass of silica and (B) 0.005 to 0.2% by mass of hinokitiol are mixed with an oral composition containing 0.1% (C) ascorbic acid phosphate or a salt thereof. The method for improving the sterilizing power of hinokitiol in the composition for oral cavity, characterized by comprising ~ 2% by mass.

  According to the present invention, the sterilizing power of hinokitiol is improved, it gives a moderate feeling of cleanliness and has an excellent bactericidal effect on pathogenic bacteria in the oral cavity, and is effective in preventing or suppressing oral diseases such as periodontal disease. An oral composition can be provided.

  The composition for oral cavity of the present invention contains (A) silica, (B) hinokitiol, and (C) ascorbic acid phosphate ester or a salt thereof.

  As the silica of component (A), one or more selected from (A-1) abrasive silica and (A-2) thickened silica can be used. In this case, (A-1) abrasive silica and / or (A-2) thickened silica can be used, but (A-1) abrasive silica is preferred, and (A-1) together with abrasive silica If necessary, (A-2) thickening silica may be included, and (A-1) abrasive silica and (A-2) thickening silica may be used.

(A-1) As the abrasive silica, those having a median diameter (d50) using a volume average of 5 to 40 μm, particularly 10 to 30 μm can be used. In addition, the median diameter of the silica is a value measured using a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium: water) (the same applies hereinafter).
Examples of the abrasive silica include compounds containing silicates such as silicic anhydride such as precipitated silica and igneous silica, aluminosilicate, zirconosilicate and titanium-bonded silica as main components.

  As the abrasive silica, those generally used for oral compositions can be used without limitation on the production method and the kind of trace components, and commercially available products can be used. Specifically, commercial products manufactured by Tosoh Silica Co., Ltd. or Taki Chemical Co., Ltd. can be used.

  In the present invention, it is preferable that abrasive silica is blended as the main abrasive. When an abrasive type other than abrasive silica, such as calcium carbonate or aluminum hydroxide, is selected as the main abrasive, it can stably contain ascorbic acid phosphate or its salts under the influence of metal ions derived from the abrasive. In some cases, the sterilizing power of hinokitiol cannot be improved.

(A-2) As the thickening silica, silica obtained by a known production method such as precipitated silica or ignitable silica having a liquid absorption amount of 2 to 3 ml / g can be used. Thickened silica has the above-described liquid absorption amount, is fine, has little abrasiveness, and is not usually used as an abrasive. In addition, the liquid absorption amount of (A-1) abrasive silica is usually less than 2 ml / g, and is different from the liquid absorption amount of (A-2) thickening silica.
The above liquid absorption amount is as follows (hereinafter the same).
A sample (1.0 g) is weighed on a clean glass plate, and the sample is mixed with a stainless steel spatula while adding 42.5% by mass of glycerin little by little using a microburette. The amount of liquid (ml) required until the sample became one lump and peeled cleanly from the glass plate with a spatula was taken as the liquid absorption amount.

  As such thickening silica, commercially available ones can be used, for example, Carplex # 67Q manufactured by DSL Japan Co., Ltd. can be used.

In this invention, the compounding quantity of the silica of (A) component is 5-40% (mass%, hereafter the same) of the whole composition, Preferably it is 5-35%, More preferably, it is 10-30%. is there.
Furthermore, (A-1) abrasive silica and / or (A-2) thickening silica can be blended within the range of the amount of component (A), and (A-1) of abrasive silica. Although the compounding quantity with respect to the whole composition can be 5 to 40%, 5 to 30% is especially preferable, More preferably, it is 5 to 27%, More preferably, it is 9 to 24%. Moreover, the compounding quantity with respect to the whole composition of (A-2) thickening silica becomes like this. Preferably it is 0-10%, More preferably, it is 0-8%, More preferably, it is 1-6%.
When the content of the silica of the component (A) is within the above range, an appropriate brushing feeling can be imparted and the bactericidal power of hinokitiol can be improved satisfactorily. The greater the content, the better the effect of imparting a feeling of cleaning, but when the content is too large, it becomes impossible to impart an appropriate feeling of brushing due to a sense of incongruity, and a feeling of astringency occurs and the feeling of use is reduced.

(B) Hinokitiol is an unsaturated seven-membered ring compound also called β-tsuyapurine, and has a bactericidal effect on pathogenic bacteria in the oral cavity.
Hinokitiol includes natural tropolone separated from the phenolic components of essential oils obtained from Hinoki cypress plants such as Taiwan Hinoki, Nioihiba, Nezuko, Asunaro, Onihiba, and juniper. As hinokitiol, not only such a natural product but also a synthetic product may be used. It is also possible to use an extract or powder containing hinokitiol. For example, cypress oil, hinoki powder, hiba oil, hiba powder and the like can be mentioned, and commercially available products can also be used.

  (B) The compounding quantity of the hinokitiol of a component is 0.005-0.2% of the whole composition, Preferably it is 0.01-0.1%, More preferably, it is 0.02-0.1%. . When 0.005% or more is blended, a sufficient bactericidal effect can be imparted. The content of 0.2% or less is suitable for suppressing the appearance of off-taste and astringency and maintaining good taste.

In the present invention, (C) ascorbic acid phosphate or a salt thereof acts as an antibacterial power improver for (B) hinokitiol in the combined system of components (A) and (B).
(C) Ascorbic acid phosphate of component (C), one or more of the hydroxyl groups at any of the 2, 3, 5, and 6 positions of ascorbic acid is an ester of a compound such as phosphoric acid, polyphosphoric acid or sulfuric acid. It is a thing. Examples include ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-6-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-sulfate, etc. Examples of the salts include alkali metal salts such as sodium salt, potassium salt, calcium salt, and magnesium salt, and alkaline earth metal salts. Of these, magnesium salts and sodium salts of ascorbic acid phosphates are more preferable from the viewpoint of improving bactericidal activity while being used for oral use.

  The amount of the ascorbic acid phosphate ester or salt thereof as component (C) is 0.1 to 2% of the total composition, preferably 0.2 to 1%, more preferably 0.2 to 0. .5%. If the blending amount is less than 0.1%, the sterilizing power of hinokitiol cannot be improved and the sterilizing effect is inferior. The greater the amount, the greater the effect of improving the bactericidal power in the combined system of the components (A) and (B). However, when the amount exceeds 2%, no further improvement in the effect can be expected, and the occurrence of off-flavors is likely to occur. It is impossible to prevent a decrease in the feeling of use.

  Especially the composition for oral cavity of this invention is suitably prepared as dentifrices, such as a toothpaste, a liquid dentifrice, a liquid dentifrice, and a refined toothpaste. Moreover, in addition to the said component, another well-known component can be mix | blended as needed in the range which does not prevent the effect of this invention. For example, toothpastes can contain abrasives, binders, thickeners, surfactants and, if necessary, flavorings, sweeteners, colorants, preservatives, active ingredients and the like.

As an abrasive | polishing agent, in addition to (A-1) abrasive silica, you may mix | blend another abrasive | polishing agent in the range which does not inhibit the effect of this invention. For example, dicalcium phosphate dihydrate and anhydrous, tricalcium phosphate, calcium carbonate such as calcium carbonate, aluminum hydroxide, synthetic resin abrasive, and the like.
The blending amount of the abrasive other than the above-described abrasive silica is desirably within a range not deteriorating the stability of the ascorbic acid phosphate or a salt thereof, and is preferably 0 to 5%, particularly preferably 0 to 3% of the entire composition. In addition, it is desirable not to mix | blend abrasives other than a silica type abrasive | polishing agent.

  Examples of the thickener include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as glycerin and propylene glycol. The blending amount of the thickener is usually 5 to 50%, particularly 20 to 45%.

  As a binder, in addition to (A-2) thickening silica, another organic or inorganic binder can be mix | blended. Specific examples include organic binders such as cellulose derivatives such as sodium carboxymethyl cellulose, hydroxymethyl cellulose, and hydroxyethyl cellulose, alginic acid derivatives, and gums such as xanthan gum, and inorganic binders such as bee gum and laponite. The compounding amount of these binders is usually 0.1 to 10%, particularly 0.1 to 8%, and is preferably within the above range including the compounding amount of (A-2) thickening silica.

As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, N-acyl sarcosinate, and sodium α-olefin sulfonate.
Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, hexaglyceryl monomyristate, decaglyceryl monolaurate, polyglycerin fatty acid esters such as polyoxy Examples include ethylene fatty acid esters, polyoxyethylene higher alcohol ethers, and fatty acid alkanolamides.
Examples of the cationic surfactant include alkylammonium types, and examples of amphoteric surfactants include betaines such as alkylbetaines and acetic acid betaines, and imidazolines.
The blending amount of the surfactant is preferably 0.001 to 10%, particularly 0.01 to 5%, particularly preferably 0.1 to 2% of the entire composition.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-1-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Oral compositions such as single flavors such as o-acetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above. In addition, the compounding quantity of a fragrance | flavor is the range of 0.00001-1% normally, and it is preferable to use said fragrance | flavor raw material 0.000001-1% in a composition. As a fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material, it is preferable to use 0.1 to 2% during a formulation composition.

  Examples of the sweetener include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester, benzoic acid and salts thereof.

  As active ingredients, known ingredients usually incorporated in oral compositions, for example, nonionic fungicides such as isopropylmethylphenol, cationic fungicides such as cetylpyridinium chloride, tranexamic acid, epsilon aminocaproic acid, allantoin, glycyrrhetin Acids, anti-inflammatory agents such as glycyrrhizic acid, enzymes such as dextranase, fluorides such as sodium fluoride and sodium monofluorophosphate, water-soluble phosphate compounds, copper compounds, hypersensitivity-inhibiting ingredients, inorganic salts, ascorbic acid And plant extracts such as vitamins such as tocopherol acetate, toki soft extract, thyme, ougon, clove, and hamamelis. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified. Further, the median diameter (d50) of the abrasive silica and the liquid absorption amount of the thickening silica are values measured by the above methods, respectively.

[Examples and Comparative Examples]
Oral compositions (dentifrice compositions) having the compositions shown in Tables 1 and 2 were prepared by a conventional method and evaluated by the following methods. The results are shown in Tables 1 and 2.

<Experimental Example 1> Evaluation Test of Bactericidal Effect of Oral Pathogenic Bacteria 10 g of the dentifrice composition was weighed, and artificial saliva (100 mL) was added and the suspension stirred until uniform was used as the sample solution. Todd Hewitt Bros (Nippon Becton Dickinson Co., Ltd.) with hemin (Wako Pure Chemical Industries, 500 μg / ml) and menadione (Wako Pure Chemicals, 100 μg / ml) added A bacterial suspension was prepared so that the pre-cultured Porphyromonas gingivalis strain ATCC33277 was 1 × 10 ⁹ cells / mL with physiological saline. The bacterial solution and sample solution were mixed at 1: 1 (volume ratio) and allowed to stand for 3 minutes. Thereafter, serial dilution was performed 10 times with physiological saline, and smeared on a blood agar plate using a spiral plater. In addition, it tested similarly using what mixed physiological saline and fungus | bacterial solution 1: 1 (volume ratio) instead of the chemical | medical agent as a control | contrast. The blood plate was cultured at 37 ° C. under anaerobic conditions (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) for 5 days, and the number of colonies formed was counted.
The bactericidal test for pathogenic bacteria in the oral cavity was carried out with n = 5, and the bactericidal rate was calculated from the number of colonies by the following formula. An average value was obtained, and the bactericidal effect of oral pathogenic bacteria was evaluated according to the following criteria.

Evaluation standard for bactericidal effect of oral pathogenic bacteria ◎: Bactericidal rate 80% or more ○: Bactericidal rate 60% or more and less than 80% △: Bactericidal rate 40% or more and less than 60% ×: Bactericidal rate 40% or less

<Experimental example 2> Evaluation method of feeling of brushing About 1 g of the dentifrice composition was placed on a toothbrush having a brush head width of 10 mm and a length of 20 mm, and the feeling of brushing when brushed was subjected to sensory evaluation according to the following criteria: Judged. An average value of 10 subjects was obtained and evaluated according to the following evaluation criteria. Those for which the evaluations of 及 び and ○ were ensured were judged to be a dentifrice composition with a feeling of brushing.
Evaluation criteria for brushing feeling 4 points: Feeling the brushing feeling very much 3 points: Feeling the brushing feeling 2 points: Feeling the brushing feeling slightly 1 point: Feeling the brushing feeling not felt at all ◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

<Experimental example 3> Evaluation method of taste of taste and astringency A sensory test was conducted using 10 expert panelists. About 0.5 g of the dentifrice composition was placed on a commercial product toothbrush and brushed for 3 minutes. The taste of taste and astringency felt during use was sensory-evaluated according to the following criteria and judged. An average value of the evaluation results of 10 people was obtained and judged according to the following evaluation criteria. Those for which the evaluations of 及 び and ○ were ensured were judged to be dentifrice compositions having no taste and astringency and good taste.
Evaluation criteria for no taste or astringency 4 points: No taste or astringency 3 points: Slight taste or astringency 2 points: Slight taste or astringency 1 point: A taste or astringency Criteria for evaluation of taste and astringency ◎: 3.5 points to 4.0 points ○: 3.0 points to less than 3.5 points △: 2.0 points to less than 3.0 points ×: 2.0 Less than

Details of the raw materials used are shown below.
(A) (A-1) Abrasive silica; median diameter (d50) in the range of 5 to 40 μm,
Manufactured by Tosoh Silica Co., Ltd. (A-2) thickening silica: in the range of liquid absorption 2.0-3.0 ml / g,
Carplex # 67Q, manufactured by DSL Japan Co., Ltd. (B) Hinokitiol; manufactured by Wako Pure Chemical Industries, Ltd. (C) Magnesium ascorbic acid phosphate; manufactured by Showa Denko Co., Ltd.

  As shown in the Examples and Comparative Examples of Tables 1 and 2, when hinokitiol is blended with silica, the bactericidal effect is reduced (Comparative Examples 7 and 8), and even if ascorbic acid phosphate is added, the blending amount is small. And the bactericidal effect is inferior (Comparative Example 1), and if it is too much, the taste and astringency will appear and become unsuitable for use (Comparative Example 2). When the component (C) is blended in an appropriate amount, the sterilization power of hinokitiol is improved, and a high bactericidal effect is achieved against pathogenic bacteria in the oral cavity with a moderate feeling of cleanliness, and taste and astringency are suppressed. It became favorable (Example).

  A prescription example is shown below.

[Prescription Example 1] Toothpaste (A-1) Abrasive silica 15.0
(A-2) Thickening silica 5.0
(B) Hinokitiol 0.1
(C) Ascorbic acid phosphate magnesium 0.3
70% sorbite solution 45.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 0.2
Sodium monofluorophosphate 0.3
Titanium oxide 0.4
Fragrance 1.3
Sodium hydroxide 0.14
Purified water balance
Total 100.0%

[Prescription Example 2] Toothpaste (A-1) Abrasive silica 15.0
(A-2) Thickening silica 5.0
(B) Hinokitiol 0.1
(C) Ascorbic acid phosphate magnesium 0.3
70% sorbite solution 45.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 0.2
Sodium fluoride 0.2
Titanium oxide 0.4
Fragrance 1.3
Sodium hydroxide 0.14
Purified water balance
Total 100.0%

[Formulation Example 3] Toothpaste (A-1) Abrasive silica 15.0
(A-2) Thickening silica 5.0
(B) Hinokitiol 0.1
(C) Ascorbic acid phosphate magnesium 0.3
70% sorbite solution 45.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 0.2
Sodium fluoride 0.1
Titanium oxide 0.4
Fragrance 1.3
Sodium hydroxide 0.14
Purified water balance
Total 100.0%

[Formulation Example 4] Toothpaste (A-1) Abrasive silica 15.0
(A-2) Thickening silica 5.0
(B) Hinokitiol 0.1
(C) Ascorbic acid sodium phosphate 0.3
70% sorbite solution 45.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 0.2
Sodium fluoride 0.1
Titanium oxide 0.4
Fragrance 1.3
Sodium hydroxide 0.14
Purified water balance
Total 100.0%

[Prescription Example 5] Toothpaste (A-1) Abrasive silica 15.0
(A-2) Thickening silica 5.0
(B) Hinokitiol 0.1
(C) Ascorbic acid sodium phosphate 0.3
Ascorbic acid glucoside 10.0
70% sorbite solution 45.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 0.2
Sodium fluoride 0.1
Titanium oxide 0.4
Fragrance 1.3
Sodium hydroxide 0.14
Purified water balance
Total 100.0%

Claims (7)

  (A) 5 to 40% by mass of silica and (B) 0.005 to 0.2% by mass of hinokitiol are mixed with an oral composition containing 0.1% (C) ascorbic acid phosphate or a salt thereof. A composition for oral cavity characterized by containing ˜2% by mass.   The composition for oral cavity according to claim 1, wherein the component (A) is (A-1) abrasive silica and / or (A-2) thickened silica.   The oral composition according to claim 1, wherein the component (A) is (A-1) abrasive silica, or (A-1) abrasive silica and (A-2) thickened silica.   The oral cavity according to claim 2 or 3, wherein the component (A-1) is abrasive silica having a median diameter of 5 to 40 µm, and the component (A-2) is thickening silica having a liquid absorption amount of 2 to 3 ml / g. Composition.   The composition for oral cavity according to claim 3 or 4, wherein the compounding amount of the component (A-1) is 5 to 30% by mass and the compounding amount of the component (A-2) is 0 to 10% by mass.   (C) The composition for oral cavity according to any one of claims 1 to 5, wherein the ascorbic acid phosphate or a salt thereof is a magnesium salt or a sodium salt of ascorbic acid phosphate.   (A) 5 to 40% by mass of silica and (B) 0.005 to 0.2% by mass of hinokitiol are mixed with an oral composition containing 0.1% (C) ascorbic acid phosphate or a salt thereof. The method for improving the sterilizing power of hinokitiol in the composition for oral cavity, characterized by comprising ~ 2% by mass.