WO2013077127A1

WO2013077127A1 - Dentifrice composition and agent for promoting tooth recalcification

Info

Publication number: WO2013077127A1
Application number: PCT/JP2012/077286
Authority: WO
Inventors: 誠吉江; 佐野　浩史; 剛太郎飯泉
Original assignee: ライオン株式会社
Priority date: 2011-11-25
Filing date: 2012-10-23
Publication date: 2013-05-30
Also published as: CN103974689B; KR101909321B1; JP5720546B2; KR20140098059A; MY164108A; JP2013112613A; CN103974689A

Abstract

Provided are a dentifrice composition and an agent for promoting tooth recalcification that are excellent in terms of promoting tooth recalcification and effective in cavity prevention. The dentifrice composition is characterized in containing (A) calcium carbonate microparticles having an average primary particle diameter of 1 µm or smaller and (B) a polyethylene glycol having a high degree of polymerization. The dentifrice composition further contains (C) erythritol and (D) a fluorine compound. The agent for promoting tooth recalcification comprises (A) calcium carbonate microparticles having an average primary particle diameter of 1 µm or smaller and (B) a polyethylene glycol having a high degree of polymerization.

Description

Dentifrice composition and tooth remineralization accelerator

The present invention relates to a dentifrice composition and a tooth remineralization accelerator that are excellent in the effect of promoting tooth remineralization and effective in preventing dental caries.

In general, the calcium concentration in human saliva is said to be about 1.0 to 3.0 mM, and if more calcium ions are present, the saturation with respect to hydroxyapatite increases and remineralization has been promoted for a long time. Are known.

As a known technique for supplying calcium into the oral cavity, colloidal calcium carbonate is used as a neutralizing agent for acid produced in plaque, and as a result of neutralization, it is released into the oral cavity as Ca ²⁺ ions (patented) (Reference 1: Japanese Patent Laid-Open No. 9-295924), calcium phosphate compounds, eggshell, cereal powder, etc. are mixed and fermented, and the liquefied substance is used in the oral cavity to promote remineralization and whiten the teeth. A technology to be provided (Patent Document 2; JP-A-8-319224) is known.

On the other hand, in the field of oral care, polyethylene glycol is generally used as a humectant or thickener. However, there are few examples of blending highly polymerized polyethylene glycol having a molecular weight of 100,000 or more in the preparation, and there are some examples (Patent Document 3; JP-A-2006-506359) used for improving the foaming performance of liquid dentifrices. There is no description that highly polymerized polyethylene glycol has any effect on remineralization. No mention is made of remineralization with highly polymerized polyethylene glycol.

Recently, xylitol, erythritol and the like have been attracting attention as substitute sweeteners, and are blended in strawberries, gums, soft drinks and the like. The functions of polyhydric alcohols typified by xylitol have been reported to be non-fermentative, suppressive growth of Streptococcus mutans (S. mutans) bacteria, which are said to be cariogenic, and promote remineralization. Known techniques for anti-caries using erythritol include techniques for providing chewing gum, confectionery, ice cream, carbonated beverages and oral cleansing liquid containing erythritol (Patent Document 4; JP 55-34098 A, Patent Document 5; JP-A-10-33138) has been proposed, and Patent Document 5 shows that the anti-cariogenic property of erythritol is quite similar to that of xylitol. However, regarding erythritol, there is no literature that mentions decalcification.

Japanese Patent Laid-Open No. 9-295924 JP-A-8-319224 JP 2006-506359 A JP 55-34098 A Japanese Patent Laid-Open No. 10-33138

Thus, various proposals have been made for remineralization in the past, but a new technique for providing a more effective dentifrice composition for promoting remineralization is required.

This invention is made | formed in view of the said situation, It aims at providing the dentifrice composition which is excellent in the remineralization promotion effect of a tooth | gear, and has a high caries prevention effect, and a remineralization promoter of a tooth. .

As a result of intensive studies to achieve the above object, the present inventors have found that in a combined system of (A) fine calcium carbonate having an average primary particle diameter of 1 μm or less and (B) a highly polymerized polyethylene glycol, It discovered that it had the outstanding effect with respect to remineralization promotion, and came to make this invention. Furthermore, when erythritol is added to the above combination system, the effect of preventing demineralization in addition to the effect of promoting remineralization is improved, and particularly when the water content of the composition is 25% by mass or less, the refreshing feeling is improved. It was found that the feeling was good.

That is, the applicant, as calcium carbonate capable of exhibiting the acid neutralizing ability of dental plaque or the effect of preventing dental caries, has a particle size of 50% by mass or more as a primary particle size within a particle diameter of 0.04 to 0.5 μm. Although it was proposed in Patent Document 1 that a certain fine calcium carbonate is effective, the effect of promoting remineralization by the fine calcium carbonate is not sufficient and there is room for improvement. Therefore, the present inventors have further studied the promotion of remineralization by fine calcium carbonate. When the highly polymerized polyethylene glycol (B) is used in combination with the fine calcium carbonate (A), both of them are surprisingly both. It has been found that the components act synergistically and have a significantly high remineralization promoting effect. In general, dental remineralization means that the pH in the plaque tends to be acidic and the elution of minerals (Ca ²⁺ and HPO ₄ ²⁻ ) occurs, and then the pH tends to neutral due to the action of saliva, This is the action that minerals once melted return to the tooth surface and restore the melted tooth surface. By the above combination system, fine calcium carbonate spreads to the details in the oral cavity and the acid caused by dental plaque. It is presumed that mineral re-deposition is promoted by neutralization and calcium ion supplementation, and remineralization is promoted.
In the present invention, the highly polymerized polyethylene glycol enhances the remineralization accelerating effect and exhibits a special effect. From the blend of polyethylene glycol as a moisturizing agent and a thickener of the dentifrice composition, ( The exceptional effects of the combined use of components A) and (B) cannot be expected.

Accordingly, the present invention provides the following dentifrice composition and tooth remineralization accelerator.
[1]
(A) Fine calcium carbonate having an average primary particle size of 1 μm or less,
(B) A dentifrice composition comprising a highly polymerized polyethylene glycol.
[2]
The dentifrice composition according to [1], wherein the highly polymerized polyethylene glycol (B) has an average molecular weight of 100,000 or more.
[3]
The dentifrice composition according to [1] or [2], comprising 0.1 to 10% by mass of component (A) and 0.01 to 0.5% by mass of component (B).
[4]
The dentifrice composition according to [1], [2] or [3], wherein the component (A) / component (B) is 0.2 to 1,000 in terms of mass ratio.
[5]
The dentifrice composition according to any one of [1] to [4], further comprising (C) erythritol.
[6]
The dentifrice composition according to [5], wherein the amount of water in the composition is 25% by mass or less.
[7]
The dentifrice composition according to any one of [1] to [6], further comprising (D) a fluorine compound.
[8]
The dentifrice composition according to any one of [1] to [7], further comprising a silica-based abrasive.
[9]
(A) A tooth remineralization accelerator comprising fine calcium carbonate having an average primary particle diameter of 1 μm or less and (B) highly polymerized polyethylene glycol.
[10]
[9] The tooth remineralization accelerator according to [9], wherein the component (A) / component (B) is 0.2 to 1,000 in terms of mass ratio.
[11]
Further, (C) The tooth remineralization promoter according to [9] or [10], comprising erythritol.
[12]
Use of (A) fine calcium carbonate having an average primary particle diameter of 1 μm or less and (B) highly polymerized polyethylene glycol for producing a tooth remineralization accelerator.

According to the present invention, it is possible to provide a dentifrice composition that improves the effect of promoting remineralization of teeth and exhibits a high caries prevention effect. Moreover, a demineralization inhibitory effect improves with a remineralization promotion effect, and the caries prevention effect can be improved more. Furthermore, a refreshing feeling can be improved and a preparation with a good feeling of use can be provided.

Hereinafter, the present invention will be described in further detail. The dentifrice composition of the present invention is characterized by blending (A) fine calcium carbonate having an average primary particle diameter of 1 μm or less and (B) highly polymerized polyethylene glycol. Furthermore, (C) erythritol can be mix | blended suitably.

(A) Fine calcium carbonate having an average primary particle size of 1 μm or less is blended as a remineralization accelerator.
The fine calcium carbonate as component (A) has an average primary particle size of 1 μm or less, preferably 0.04 to 0.5 μm. When the average primary particle diameter exceeds 1 μm, the effectiveness decreases and a satisfactory remineralization promoting effect cannot be obtained. In addition, a thing with an average primary particle diameter of less than 0.04 micrometer may be difficult to manufacture.
Here, the primary particle diameter of the fine calcium carbonate is a value obtained by measuring the size of the particles with an electron microscope, and the measurement method is as follows.
Disperse the particles in water, further irradiate with ultrasonic waves for a few minutes to highly disperse, drop a small amount of this dispersion onto a holder for electron microscope observation, dry it, and finally evaporate it for electron microscope observation It was. For the measurement of the particle diameter, only particles that could be recognized as primary particles from four different visual fields were selected (25 particles per visual field) and measured. When the particles were indefinite, the square root of the product of the longest diameter and the shortest diameter was taken as the primary particle diameter. A total of 100 primary particle sizes were averaged as the average particle size of the primary particles.

As the fine calcium carbonate as the component (A), those having 50% by mass or more, especially 90% by mass or more of particles having a primary particle size of 0.04 to 0.5 μm as the primary particle size are remineralized. This is more preferable from the viewpoint of effectiveness of the promoting effect.
The fine calcium carbonate releases free calcium ions and suppresses dissolution of minerals (calcium apatite), and at the same time promotes remineralization (mineral re-deposition). When the particle diameter exceeds the primary particle size, the effect is inferior. Usually, the average primary particle diameter of calcium carbonate used as an abrasive exceeds 1 μm, and most is 5 to 8 μm. In this case, particles having a primary particle diameter of 0.5 μm or less are contained in an amount of about 1 to 3% by mass, but such calcium carbonate does not have an effect of promoting remineralization.

As the fine calcium carbonate, light calcium carbonate can be suitably used from the viewpoint of the production method such as easy control of the particle size distribution.

As the fine calcium carbonate of component (A), for example, commercially available products such as trade names Calessen-A, Corocarso-EX, Corocarso-MG manufactured by Shiraishi Calcium Co., Ltd. can be used.

The blending amount of the component (A) is preferably 0.1 to 10% (mass%, the same applies hereinafter), particularly 0.5 to 10%, particularly 0.5 to 2% of the total composition. If the blending amount is 0.1% or more, a sufficient blending effect can be obtained, but even if blending exceeds 10%, the effect may not be expected.

In the present invention, by using (B) highly polymerized polyethylene glycol in combination with (A) fine calcium carbonate, the remineralization effect of the component (A) is improved, and a high remineralization promoting effect is achieved. If the component is absent, the effect of promoting remineralization is not exhibited, and if the component (B) is absent, the effect of promoting remineralization is inferior, and the object of the present invention is not achieved.

(B) As the highly polymerized polyethylene glycol, a highly polymerized polyethylene glycol having an average molecular weight of 100,000 or more, particularly 100,000 to 5,000,000 is suitable, more preferably an average molecular weight of 100,000 to 4,000,000, still more preferably 200,000 to Those in the range of 1 million, especially 200,000 to 250,000 are preferred. Those having an average molecular weight of 100,000 or more are preferable because a high remineralization promoting effect can be expected. If it exceeds 5 million, the remineralization promoting effect may not be observed, and the stability of the dentifrice may be lowered.
The above average molecular weight is a viscosity average molecular weight, and this viscosity average molecular weight is a value converted from viscosity measurement. Specifically, a chain height that satisfies the relationship expressed by the Staudinger equation between the molecular weight and the molecular weight. It is a value obtained by measuring the intrinsic viscosity of a molecule (hereinafter the same).
Further, as a substitute characteristic in place of the viscosity average molecular weight, the viscosity of a 4 mass% aqueous solution at 25 ° C. (B8H viscometer, rotor No. 4, 20 rpm, 2 minutes, 25 ° C.) measured with a B type viscometer is used. You can also. The viscosity of the highly polymerized polyethylene glycol when measured by this method is preferably 50 to 50,000 mPa · s, more preferably 70 to 10,000 mPa · s, and 100 to 5,000 mPa · s. Is particularly preferred.

Highly-polymerized polyethylene glycol is commercially available. For example, POLYOX WSR N-10, N-20, N-80, N-750, N-12K, N-60K and other Polyox WSR series (Union) Commercially available).

The blending amount of the highly polymerized polyethylene glycol is preferably 0.01 to 0.5% of the total composition, more preferably 0.03 to 0.2%, and particularly preferably 0.05 to 0.1%. If the blending amount is less than 0.01%, the improvement effect of remineralization may not be recognized, and if it exceeds 0.5%, no further effect may be expected, and the stability of the dentifrice May decrease.

The blending ratio of (A) fine calcium carbonate and (B) highly polymerized polyethylene glycol is not particularly limited, but (A) / (B) is preferably 0.2 to 1,000, more preferably 5 as a mass ratio. It is desirable to be in the range of ˜100, more preferably in the range of 5 to 40, and in this range, the effect of promoting remineralization is excellent. The improvement of the remineralization promotion effect can be expected as it is 0.2 or more.

It is preferable that (C) erythritol is further blended in the composition of the present invention. When erythritol is blended, the remineralization promoting effect is further improved, and the decalcification inhibiting action is improved in addition to the remineralization promoting effect, and the caries prevention effect is further enhanced. Furthermore, a refreshing feeling can be improved and a good feeling of use can be given.

Erythritol is a sugar alcohol, and a commercially available product can be used.
When erythritol is blended, the blending amount is preferably 5 to 30%, particularly 10 to 30%, particularly 10 to 25% of the total composition. If it is less than 5%, the blending effect may not be expected, and if it exceeds 30%, no further effect can be expected and the stability of the dentifrice may be lowered.

The composition of the present invention preferably further contains (D) a fluorine compound. By adding a fluorine compound, the effect of suppressing the decalcification of teeth can be further improved, and the effect of preventing dental caries can be further enhanced.
Fluorine compounds include soluble fluorides such as alkali fluorides such as sodium fluoride, ammonium fluoride and potassium fluoride, monofluorophosphates such as sodium monofluorophosphate, ammonium monofluorophosphate and potassium monofluorophosphate. Compounds.
When a fluorine compound is blended, the blending amount is preferably 400 to 1,500 ppm, particularly 500 to 1,000 ppm as fluorine ions with respect to the entire composition. If it is less than 400 ppm, the blending effect may not be obtained, and if it exceeds 1,500 ppm, the stability of the dentifrice composition may be lowered.

The dentifrice composition of the present invention is suitably prepared as a toothpaste, a liquid dentifrice or the like, particularly as a toothpaste. Moreover, the well-known component normally used besides the said component can be mix | blended as needed according to the dosage form. For example, abrasives, thickeners, binders, surfactants, and if necessary, fragrances, sweeteners, preservatives, colorants, active ingredients other than those described above, and the like, within a range that does not interfere with the effects of the present invention Can be used.

(A) Fine calcium carbonate has almost no function as an abrasive, so an abrasive is added separately. As the abrasive, conventionally used calcium carbonate for abrasives having an average primary particle size of about 5 to 8 μm, silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, dicalcium phosphate, water, etc. Examples thereof include aluminum oxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, and synthetic resin-based abrasive. Among these, silica-based abrasives are more preferably blended from the viewpoint of the effect since the stability of the dentifrice composition is improved. The blending amount of the abrasive is usually 5 to 50% of the entire composition.

Examples of the thickening agent include sugar alcohols other than erythritol such as sorbit, xylit, malt, and lactit, glycerin, propylene glycol, and polyhydric alcohols such as polyethylene glycol having an average molecular weight of 190 to 1,540. The amount of these thickeners is usually 5 to 50%.

Examples of the binder include sodium carboxymethyl cellulose, hydroxyethyl cellulose, xanthan gum, carrageenan, sodium polyacrylate, and the like. The amount of the binder is usually 0 to 5%, particularly 0.1 to 5%.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended. Specific examples of anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, N-acyl sarcosine sodium such as sodium N-lauroyl sarcosine and sodium N-myristoyl sarcosine, and sodium α-olefin sulfonate. Etc.
Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Ether type or ester type activator such as polyhydric alcohol fatty acid ester such as fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, And fatty acid alkanolamides such as lauric acid diethanolamide.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine, and lecithin.
The blending amount of the surfactant is preferably 0.5 to 5% of the entire composition.

Examples of the sweetener include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester and sodium benzoate. Examples of the colorant include blue No. 1, yellow No. 4, and the like.

Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfume and menthol) Carvone, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted-paramenthane 3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Toothpaste compositions such as single flavors such as thioacetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above.

Active ingredients include water-soluble phosphate compounds, enzymes such as dextranase, mutanase, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon aminocaproic acid, acetic acid dl-tocophenol, α-bisabolol, isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate and other copper compounds, aluminum lactate, strontium chloride, potassium nitrate, berberine, etc. . In addition, an effective amount can be mix | blended with these active ingredients in the range which does not prevent the effect of this invention.

The amount of water in the composition of the present invention is not particularly limited, but is preferably 50% or less, more preferably 25% or less, and particularly preferably 15% or less, from the viewpoint of deashing suppression effect and imparting a refreshing feeling.
In particular, when erythritol is added, especially when erythritol is blended at a high concentration of 10% or more, it is desirable that the water content is 25% or less, thereby improving the refreshing feeling due to the interaction with erythritol. It can give a very good refreshing feeling that the user can satisfy.

Further, the tooth remineralization accelerator of the present invention comprises (A) fine calcium carbonate having an average primary particle diameter of 1 μm or less and (B) highly polymerized polyethylene glycol, and more preferably (C) erythritol. .
The components (A), (B), and (C) are the same as described above, and the ratio of the component (A) / (B) is the same as described above.

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions having the compositions shown in Tables 1 to 4 were prepared by a conventional method, and the remineralization promoting effect was evaluated by the following method. The results are shown in Tables 1 to 4.

The details of the raw materials used are as follows. The average primary particle diameter of the fine calcium carbonate is a value measured with an electron microscope in the same manner as described above. The viscosity average molecular weight of the highly polymerized polyethylene glycol was measured in the same manner as described above.
(A) Fine calcium carbonate Corocalso-EX (Shiraishi Calcium Co., Ltd., average primary particle size 0.25 μm)
Cal Essen-A (Shiraishi Calcium Co., Ltd., average primary particle size 0.07 μm)
(B) Highly polymerized polyethylene glycol POLYOX WSR N-80 (manufactured by Union Carbide, viscosity average molecular weight 200,000)
POLYOX WSR N-10 (Union Carbide, viscosity average molecular weight 100,000)
POLYOX WSR N-750 (manufactured by Union Carbide, viscosity average molecular weight 300,000)
POLYOX WSR N-12K (manufactured by Union Carbide, viscosity average molecular weight 1 million)
(C) Erythritol (Cargill, 60 mesh product)

(1) Evaluation method of remineralization promoting effect A dental caries sample was prepared by immersing a tooth section of a human molar in a decalcification solution of pH 4.21. CMR (Contact Micro Radiography) was photographed, and after confirming whether surface demineralization was performed, the surface mineral density and demineralized area were calculated. This was used as an initial caries sample. Using the above sample, treatment with dentifrice composition for 3 minutes → water washing → immersion in decalcification solution (pH 4.5) for 4 hours → water washing → treatment with dentifrice composition for 3 minutes → water washing → remineralization liquid A cycle test of immersion for 20 hours in (pH 6.5) → water washing was repeated for 3 weeks. The CMR of this carious sample was photographed and subjected to image analysis, and the recovery rate of mineral content (remineralization rate (%)) was calculated by the following formula and evaluated according to the following criteria.

Evaluation standard of remineralization promotion effect ◎: Remineralization rate is 60% or more ○: Remineralization rate is 50% or more and less than 60% Δ: Remineralization rate is 30% or more and less than 50% ×: Remineralization rate Is less than 30%

(2) Evaluation method of demineralization inhibitory effect The root part of bovine teeth is cut, and the surface of the root part is polished with No. 300 sandpaper, and then polished with No. 1,500 sandpaper to make it flat and smooth. A dentin surface was obtained and trimmed to a certain size to obtain a sample piece. The dentin sample piece was covered with water-resistant nail polish except for a certain area (3 mm diameter circle, hereinafter abbreviated as test surface). This test surface was immersed for 3 minutes in a slurry obtained by diluting each dentifrice composition with water twice. Thereafter, excess components were removed by washing with water, and 15 μL of a dentin decalcifying acid (0.6% acetic acid solution, pH 4.5) was dropped onto the test surface to decalcify for 30 minutes. Then, this sample piece was poured into 1 mL of distilled water together with 1 μL of acetic acid solution, and mineral ions dissolved in acetic acid were extracted by a decalcification operation. Subsequently, after removing the sample piece from distilled water and removing excess water, the same treatment, decalcification, and extraction of mineral ions were repeated twice. Among the mineral ions extracted and accumulated in 1 mL, the phosphoric acid concentration (ppm) was measured using the vanadomolybdic acid method by absorbance. The test surface was immersed in water for 3 minutes and treated similarly, and the phosphoric acid concentration was measured in the same manner. The decalcification inhibition rate was calculated by the following formula and evaluated according to the following criteria.

Evaluation standard for deashing suppression effect ◎: Deashing suppression rate is 70% or more ○: Deashing suppression rate is 50% or more and less than 70% △: Deashing suppression rate is 30% or more and less than 50% ×: Deashing suppression rate Less than 30%

(3) Evaluation method of cool feeling Using 10 subjects, about 1 g of the dentifrice composition is put on a toothbrush, and the refreshing feeling when brushing for 3 minutes is very good, and the cool feeling is 4 points. 3 points, 2 points with little refreshing feeling, and 1 point with no cooling feeling, the feeling of use was evaluated according to the following criteria from the average score of 10 people.
Evaluation criteria for refreshing feeling ◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average 1.0 point or more and less than 2.0 point

Claims

(A) Fine calcium carbonate having an average primary particle size of 1 μm or less,
(B) A dentifrice composition comprising a highly polymerized polyethylene glycol.
The dentifrice composition according to claim 1, wherein the highly polymerized polyethylene glycol as component (B) has an average molecular weight of 100,000 or more.
The dentifrice composition according to claim 1 or 2, comprising 0.1 to 10% by mass of component (A) and 0.01 to 0.5% by mass of component (B).
The dentifrice composition according to claim 1, 2 or 3, wherein (A) component / (B) component is 0.2 to 1,000 as a mass ratio.
The dentifrice composition according to any one of claims 1 to 4, further comprising (C) erythritol.
The dentifrice composition according to claim 5, wherein the water content in the composition is 25% by mass or less.
The dentifrice composition according to any one of claims 1 to 6, further comprising (D) a fluorine compound.
Furthermore, the dentifrice composition of any one of Claim 1 thru | or 7 formed by mix | blending a silica type abrasive | polishing agent.
(A) A tooth remineralization accelerator comprising fine calcium carbonate having an average primary particle diameter of 1 μm or less and (B) highly polymerized polyethylene glycol.
The tooth remineralization accelerator according to claim 9, wherein the component (A) / component (B) is 0.2 to 1,000 in terms of mass ratio.
The tooth remineralization promoter according to claim 9 or 10, further comprising (C) erythritol.
Use of (A) fine calcium carbonate having an average primary particle diameter of 1 μm or less and (B) highly polymerized polyethylene glycol for producing a tooth remineralization accelerator.