KR20140098059A - Dentifrice composition and agent for promoting tooth recalcification - Google Patents

Abstract

The present invention provides a dentifrice composition which is excellent in accelerating the rejuvenation of teeth and effective for preventing dental caries, and a dental rejuvenation accelerator. (A) calcium carbonate fine particles having an average primary particle diameter of 1 탆 or less, and (B) highly polymerized polyethylene glycol. Also, the above-described skirt composition comprising (C) erythritol. Further, the above-described dentifrice composition comprising (D) a fluorine compound. (A) Calcium carbonate fine particles having an average primary particle diameter of 1 탆 or less and (B) Highly polymerized polyethylene glycol.

Description

[0001] DENTAL COMPOSITION AND AGENT FOR PROMOTING TOOTH RECORCIFICATION [0002]

The present invention relates to a dentifrice composition which is excellent in the effect of promoting remineralization of a tooth and is effective for preventing dental caries, and a dentifrice rejuvenation accelerator.

In general, it is said that the calcium concentration in human saliva is about 1.0 to 3.0 mM, and if there are more calcium ions, the degree of saturation to hydroxyapatite is increased and the recalcification is accelerated.

As a known technique for supplying calcium into the oral cavity, there is known a technique in which colloidal calcium carbonate is used as a neutralizing agent for acid produced in the plaque, and the resultant is released into the oral cavity as Ca ^{2 +} ions as a result of neutralization (Patent Document 1: Japanese Patent Application Laid-Open No. 9-295924), but also calcium phosphate-based compounds and egg shells (egg shells, cereal powders, etc.) are mixed and fermented to use a liquefied substance in the oral cavity to promote rejuvenation, (Patent Document 2; Japanese Patent Application Laid-Open No. 8-319224), and the like.

On the other hand, in the field of oral care, polyethylene glycol is generally used as a moisturizing agent or a thickener. However, there are few examples in which a high polymerized polyethylene glycol having a molecular weight of 100,000 or more is blended into a preparation, and examples used for foam generation (improvement of foam stability) of a liquid skimming agent (Patent Document 3: 2006-506359), and there is no description that high-polymerized polyethylene glycol has any influence on re-crystallization. Remarketing by high-polymerized polyethylene glycol is not mentioned.

In recent years, xylitol and erythritol have been attracting attention as substitute sweeteners, and they have been mixed with sugar, gum and soft drinks. The functions of polyhydric alcohols typified by xylitol have been reported to inhibit the growth of Streptococcus mutans, which is said to be a non-inducible, caries-causing microorganism, and to promote remineralization. As a known art relating to anti-caries using erythritol, there have been known techniques for providing erythritol-containing chewing gum, sugar confection, ice cream, carbonated drink, mouthwash (Patent Document 4: Japanese Patent Application Laid- Patent Document 5, Japanese Patent Application Laid-Open No. 10-33138) and the like, and Patent Document 5 shows that the anticellulosity of erythritol is very similar to that of xylitol. However, with respect to erythritol, the literature referring to demineralization is inconspicuous.

Patent Document 1: Japanese Patent Application Laid-Open No. 9-295924 Patent Document 2: Japanese Patent Application Laid-Open No. 8-319224 Patent Document 3: JP-A 2006-506359 Patent Document 4: Japanese Patent Application Laid-Open No. 55-34098 Patent Document 5: Japanese Patent Application Laid-Open No. 10-33138

As described above, various proposals have been made regarding re-screening in the past, but a new technique for giving a more effective skirt composition to promoting re-painting is required.

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition which is excellent in accelerating the re-coating of teeth and achieves a high caries prevention effect, and a dentifrice rejuvenation accelerator.

Means for Solving the Problems As a result of diligent studies to achieve the above object, the present inventors have found that (A) a combination of calcium carbonate having an average primary particle diameter of 1 탆 or less and (B) highly polymerized polyethylene glycol, The present invention has been accomplished. Further, it has been found that the addition of erythritol to the combination system improves the effect of preventing demineralization in addition to the effect of accelerating re-crystallization, and in particular, when the water content of the composition is 25 mass% or less, the cooling sensation is improved and a good feeling of use is obtained .

That is, the applicant has found that calcium carbonate which can exhibit the acid neutralizing ability or caries-preventing effect of plaque, and that fine calcium carbonate having a particle size of 0.04 to 0.5 mu m as a primary particle size of 50 mass% 1, it is difficult to say that the effect of promoting remineralization by fine calcium carbonate is sufficient, and there is room for improvement. Therefore, the inventors of the present invention found that the effect of further promoting re-crystallization by calcium carbonate of fine calcium, and the effect of using calcium carbonate as component (A) and high-polymerized polyethylene glycol as component (B) Acting synergistically, thus achieving a remarkably high rejuvenation promoting effect. In general, rejuvenation of a tooth means that pH in the plaque is tilted to an acidic state, resulting in the elution of minerals (Ca ^{2 +} and HPO ₄ ^{2 -} ), and then the pH is tilted in the neutral direction due to the action of saliva, The minerals once eluted are returned to the surface of the teeth and restoration of the surface of the molten tooth is performed. By this combination system, the fine calcium carbonate is uniformly dispersed to the details in the oral cavity, It is presumed that the re-deposition of minerals is promoted by the neutralization and the supply of calcium ions, thereby accelerating re-precipitation.

Further, in the present invention, the effect of accelerating re-crystallization is enhanced by the highly-polymerized polyethylene glycol, and the specific action and effect are achieved. From the combination of the moisturizer and the polyethylene glycol as the viscoelement, the combined use of the components (A) The above-mentioned specific action and effect can not be expected.

Accordingly, the present invention provides the following dentifrice composition and dentin remineralization accelerator.

[One]

(A) fine calcium carbonate having an average primary particle diameter of 1 탆 or less,

(B) Highly polymerized polyethylene glycol

By weight of the composition.

[2]

Wherein the high-polymerized polyethylene glycol as the component (B) has an average molecular weight of 100,000 or more.

[3]

The skirt composition according to [1] or [2], wherein the skirt composition is obtained by blending 0.1 to 10 mass% of component (A) and 0.01 to 0.5 mass% of component (B)

[4]

The skirt composition according to [1], [2] or [3], wherein the component (A) / component (B) has a mass ratio of 0.2 to 1,000.

[5]

The skirt composition according to any one of [1] to [4], further comprising (C) erythritol.

[6]

The skirt composition according to [5], wherein the water content in the composition is 25 mass% or less.

[7]

The skirt composition according to any one of [1] to [6], further comprising (D) a fluorine compound.

[8]

The skirt composition according to any one of [1] to [7], further comprising a silica-based abrasive.

[9]

(A) Calcium carbonate fine particles having an average primary particle diameter of 1 탆 or less and (B) Highly polymerized polyethylene glycol.

[10]

The accelerator for resuscitation of teeth according to [9], wherein the component (A) / component (B) is 0.2 to 1,000 in mass ratio.

[11]

Further, (C) a recalcification accelerator for teeth as described in [9] or [10], which comprises erythritol.

[12]

(A) Use of fine calcium carbonate having an average primary particle diameter of 1 占 퐉 or less and (B) highly polymerized polyethylene glycol for producing a remineralization accelerator for teeth.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a dentifrice composition having an effect of accelerating reshaping of a tooth and achieving a high dental caries prevention effect. In addition, the effect of inhibiting demineralization is improved along with the effect of accelerating re-crystallization, and the effect of preventing caries can be further improved. In addition, a refreshing feeling is improved, and a preparation for a good feeling of use can be provided.

Hereinafter, the present invention will be described in more detail. The denture composition of the present invention is characterized by comprising (A) calcium carbonate fine particles having an average primary particle size of 1 탆 or less and (B) highly-polymerized polyethylene glycol. In addition, (C) erythritol can be appropriately compounded.

(A) The fine calcium carbonate having an average primary particle size of 1 탆 or less is compounded as a re-crystallization accelerator.

The fine calcium carbonate as the component (A) has an average primary particle diameter of 1 mu m or less, preferably 0.04 to 0.5 mu m. If the average primary particle size exceeds 1 탆, the effectiveness is lowered and satisfactory rejuvenation promotion effect can not be obtained. In addition, if the average primary particle diameter is less than 0.04 占 퐉, the production may be difficult.

Here, the diameter of the primary particle of the fine calcium carbonate is a value obtained by measuring the particle size by an electron microscope, and the measurement method is as follows.

The particles were dispersed in water and ultrasonic waves were irradiated for several minutes to be highly dispersed. A small amount of this dispersion was dropped on a support for observation using an electron microscope, followed by drying and finally evaporation, followed by electron microscopic observation. In the measurement of the particle diameter, only particles that can be recognized as primary particles in the other four fields of view (25 per field of view) were measured. When the particles are irregular, the square root of the product of the longest and shortest is taken as the first radius. The average of a total of 100 primary particles was taken as the average particle size of the primary particles.

As the fine calcium carbonate as the component (A), it is more preferable that the particle size of the primary particles is in the range of 0.04 to 0.5 탆, particularly 50% by mass or more, particularly 90% by mass or more, .

The fine calcium carbonate emits free calcium ions, inhibits the dissolution of minerals (calcium apatite), and accelerates recrystallization (re-deposition of minerals) at the same time. In the case of exceeding the above-mentioned first-order magnitude, this effect is inferior. Normally, the average primary particle diameter of calcium carbonate used as an abrasive is more than 1 탆, and most of the calcium carbonate is 5 to 8 탆. In this case, the primary particles include particles having a particle diameter of 0.5 탆 or less as an accumulation of about 1 to 3% by mass, but such calcium carbonate does not have the effect of accelerating re-crystallization.

As the fine calcium carbonate, light calcium carbonate can be suitably used in terms of the production method such as easy control of the particle diameter distribution.

As the fine calcium carbonate as the component (A), for example, commercially available products such as Carl Essen-A, Corocalo-EX, and Corocalmo-MG available from Shiraishi Calcium Co., Ltd. can be used.

The blending amount of the component (A) is preferably 0.1 to 10% (mass%, the same applies hereinafter), particularly 0.5 to 10%, and more preferably 0.5 to 2%. If the blending amount is 0.1% or more, a sufficient blending effect can be obtained. However, even if the blending amount exceeds 10%, the improvement of the effect may not be expected.

In the present invention, the effect of re-crystallization of the component (A) is improved and the effect of accelerating the re-crystallization is achieved by using (A) calcium carbonate of fine calcium in combination with (B) highly-polymerized polyethylene glycol, The effect of accelerating re-crystallization is not exerted, and if the component (B) is omitted, the effect of accelerating re-crystallization lags behind the object of the present invention.

(B) High-polymerized polyethylene glycols are preferably high-polymerized polyethylene glycols having an average molecular weight of 100,000 or more, particularly 100,000 to 5,000,000, more preferably 100,000 to 4,000,000, and more preferably 200,000 to 1,000,000 , Particularly preferably in the range of 200,000 to 250,000. An average molecular weight of 100,000 or more is preferable because it can be expected to accelerate re-painting. If it exceeds 5,000,000, the effect of accelerating re-painting may not be recognized, and the stability of the skirt preparation may be lowered.

The average molecular weight is a viscosity average molecular weight, and the viscosity average molecular weight is a value converted from viscosity measurement. Specifically, the average molecular weight is a value obtained by multiplying the molecular weight by the molecular weight of the chain polymer And is a value based on the intrinsic viscosity measurement (the same applies hereinafter).

As a substitute for the viscosity average molecular weight, a viscosity of 4 mass% aqueous solution at 25 캜 (B8H type viscometer, rotor No. 4, 20 rpm, 2 minutes, 25 캜) measured by a B-type viscometer It is possible. The viscosity of the highly polymerized polyethylene glycol when measured by this method is preferably 50 to 50,000 mPa · s, more preferably 70 to 10,000 mPa · s, and particularly preferably 100 to 5,000 mPa · s desirable.

Highly polymerized polyethylene glycol may be a commercially available product and may be a commercially available product such as Polyox WSR series such as POLYOX WSR N-10, N-20, N-80, N-750, N-12K, (Manufactured by Union Carbide), and the like.

The blending amount of the highly-polymerized polyethylene glycol is preferably 0.01 to 0.5%, more preferably 0.03 to 0.2%, and particularly preferably 0.05 to 0.1% of the entire composition. If the blending amount is less than 0.01%, improvement in the effect of accelerating re-painting may not be recognized. If the blending amount is more than 0.5%, further effects can not be expected and the stability of the skimming agent may be lowered.

(A) / (B) is preferably in the range of 0.2 to 1,000, more preferably in the range of 5 to 100, more preferably in the range of 5 to 100, More preferably in the range of 5 to 40, and if it is within this range, it is excellent due to the effect of accelerating re-painting. If the ratio is 0.2 or more, improvement of rejuvenation promotion effect can be expected.

The composition of the present invention preferably contains (C) erythritol. When erythritol is blended, the effect of accelerating re-crystallization is further improved, and in addition to the effect of accelerating re-crystallization, the deliming inhibitory action is improved and the effect of preventing caries is further enhanced. In addition, the cooling feeling is improved and a good feeling of use can be obtained.

Erythritol is a sugar alcohol, and a commercially available erythritol can be used.

When erythritol is blended, the blending amount thereof is preferably 5 to 30%, particularly 10 to 30%, and more preferably 10 to 25%, of the whole composition. If it is less than 5%, the compounding effect can not be expected, and if it exceeds 30%, the above effects can not be expected, and the stability of the skimming agent may be lowered.

The composition of the present invention preferably contains (D) a fluorine compound. The compounding of the fluorine compound improves the effect of suppressing the demineralization of the teeth, and can further enhance the caries prevention effect.

Examples of the fluorine compound include soluble fluorine compounds such as alkali fluoride such as sodium fluoride, ammonium fluoride, and potassium fluoride, and monofluorophosphate such as sodium monofluorophosphate, ammonium monofluorophosphate, and potassium monofluorophosphate.

When the fluorine compound is compounded, the amount of the fluorine compound is preferably 400 to 1,500 ppm, more preferably 500 to 1,000 ppm as the fluorine ion. When the content is less than 400 ppm, a blending effect may not be obtained. When the content exceeds 1,500 ppm, the stability of the dentifrice composition may be deteriorated.

The dentifrice composition of the present invention is suitably prepared as a kneading dentifrice, liquid dentifrice and the like, especially as a dentifrice. In addition, in accordance with the formulation, known components commonly used in addition to the above components can be blended as required. For example, an abradant, a tackifier, a binder, a surfactant and, if necessary, an antioxidant, a sweetener, an antiseptic, a colorant, and other effective components may be used in ordinary amounts within the range not hindering the effects of the present invention have.

(A) Since fine calcium carbonate has almost no function as an abrasive, a separate abrasive is mixed. Examples of the abrasive include a silica-based abrasive such as silica gel, precipitated silica, aluminosilicate, vinconosilicate, etc., calcium phosphate dibasic calcium phosphate, aluminum hydroxide, Alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, calcium tertiary phosphate, hydroxyapatite, calcium phosphate dibasic, synthetic resin abrasive and the like. Above all, the silica-based abrasive is more suitably compounded from the viewpoint of the effect because the stability of the dentifrice composition is improved. The blending amount of the abrasive is usually 5 to 50% of the whole composition.

Examples of the viscosifier include sugar alcohols other than erythritol such as sorbit, xylitol, maltitol and lactit, polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol having an average molecular weight of 190 to 1,540. The blending amount of these viscosifiers is usually 5 to 50%.

Examples of the binder include sodium carboxymethylcellulose, hydroxyethylcellulose, xanthan gum, carrageenan, and sodium polyacrylate. The blending amount of the binder is usually 0 to 5%, particularly 0.1 to 5%.

As the surfactant, anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants can be mixed. Specific examples of the anionic surfactant include sodium alkylsulfuric acid such as sodium laurylsulfate and sodium myristylsulfate, N-acylsarcosine sodium such as N-lauroyl sarcosine sodium and N-myristoyl sarcosine, And sodium sulfonate.

Examples of the nonionic surfactant include sugar alcohol fatty acid esters such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters and sucrose fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyethylene glycol fatty acid esters , Polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, etc., ether or ester type active agents such as lauric acid diethanolamide , And the like.

Examples of the cationic surfactant include alkylammonium, alkylbenzylammonium salts and the like. Examples of the amphoteric surfactant include betaine acetate, imidazolinium betaine, and lecithin.

The blending amount of the surfactant is preferably 0.5 to 5% of the whole composition.

Examples of the sweetener include sodium saccharin and the like, and examples of the preservative include paraoxybenzoic acid ester and sodium benzoate. Examples of the colorant include Blue No. 1, Yellow No. 4, and the like.

Examples of the flavoring agent include those selected from the group consisting of peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, time oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, The present invention relates to a method for producing a medicinal herb which is effective for the prevention and treatment of cancer, comprising the steps of: lavender oil, rosemary oil, laurel oil, camomile oil, caraway oil, marjoram oil, bayesian oil, lemongrass oil, (Natural oil) such as yuzu oil, iris concrete, Absolute Peppermint, Absolute Rose and Orange Flower, and natural natural materials such as natural treatments such as pre-cut, wake cut, Extract, essence, powder, etc.) and one or more agents selected from the group consisting of menthol, carboen, anethole, cineol, methyl salicylate, cinnamic aldehyde, ogenol, 3-l-menthoxypropane- Diol, thymol, linalool, linalool acetate, limonene, menton, menthyl acetate, N- But are not limited to, cyclopentadienyl, cyclopentadienyl, cyclopentadienyl, cyclopentadienyl, cyclopentadienyl, cyclopentadienyl, cyclopentadienyl, cyclopentadienyl, cyclopentadienyl, Methylphenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate, Known flavoring materials used in dentifrice compositions such as Strawberry Flavor, Apple Flavor, Banana Flavor, Pineapple Flavor, Grape Flavor, Mango Flavor, Butter Flavor, Milk Flavor, Fruit Mix Flavor and Tropical Fruit Flavor Can be used.

Examples of the active ingredient include enzymes such as water-soluble phosphate compounds, strains, mutans,

Allantoin chlorihydroxy aluminum, hinokin thiol, ascorbic acid, lysozyme chloride,

But are not limited to, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate,? -Bisabolol, isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, Copper chlorophyllin sodium, copper gluconate and the like, aluminum lactate, strontium chloride, potassium nitrate, berberine and the like. These effective ingredients can be blended in an effective amount within a range not hindering the effect of the present invention.

The water content (water content) of the composition of the present invention is not particularly limited, but is preferably 50% or less, more preferably 25% or less, and particularly 15% or less of the total composition in terms of demineralization suppression effect and refreshing feeling.

Particularly when erythritol is added, erythritol is preferably added at a high concentration of 10% or more, and it is preferable that the water content is 25% or less. Thus, by the interaction with erythritol, Can give a very good feeling of coolness.

The tooth remineralization accelerator of the present invention is composed of (A) calcium carbonate fine particles having an average primary particle diameter of 1 탆 or less and (B) highly polymerized polyethylene glycol, and more preferably (C) erythritol.

The components (A), (B), and (C) are the same as those described above, and the ratio of the component (A) / component (B) is also the same as described above.

Example

Hereinafter, examples and comparative examples will be shown and the present invention will be described in detail, but the present invention is not limited to the following examples. In the following examples,% represents mass% unless otherwise specified.

[Practical example, comparative example]

A dentifrice composition having the compositions shown in Tables 1 to 4 was prepared by a routine method, and the effect of accelerating remineralization was evaluated by the following method. The results are shown in Tables 1-4.

Details of the raw materials to be used are as follows. The average primary particle diameter of the fine calcium carbonate is a value measured by an electron microscope as described above. The viscosity average molecular weight of the highly polymerized polyethylene glycol was measured in the same manner as described above.

(A) Calcium carbonate

Coro-Soy-EX (manufactured by Shiraishi Calcium Co., Ltd., average primary particle size: 0.25 mu m)

(Manufactured by Shiraishi Calcium Co., Ltd., average primary particle diameter: 0.07 mu m)

(B) Highly polymerized polyethylene glycol

POLYOX WSR N-80 (manufactured by Union Carbide, viscosity average molecular weight: 200,000)

POLYOX WSR N-10 (manufactured by Union Carbide, viscosity average molecular weight: 100,000)

POLYOX WSR N-750 (manufactured by Union Carbide, viscosity average molecular weight: 300,000)

POLYOX WSR N-12K (manufactured by Union Carbide, viscosity average molecular weight: 1,000,000)

(C) Erythritol (manufactured by Cargill, 60 mesh product)

(1) Evaluation method of promotion effect

The tooth sections of human molars were immersed in a demineralized solution of pH 4.21 to prepare a caries sample. CMR (Contact Micro Radiography) was photographed to confirm whether the surface layer was demineralized, and then the surface layer mineral density and demineralized area were calculated. This was used as an initial caries sample. Using the sample, treatment with a dentifrice composition was carried out for 3 minutes, followed by washing with water, followed by immersion in dessication solution (pH 4.5) for 4 hours, washing with water, treatment with dentifrice composition for 3 minutes, washing with water, A cycle of immersion for 20 hours → water washing was repeated for 3 weeks. The CMR of the dough sample was photographed and analyzed for image, and the recovery rate (recrystallization ratio (%)) of the mineral amount was calculated by the following formula, and evaluated by the following criteria.

[Equation 1]

(%) = (Mineral density after skimming treatment - Mineral density after demining) /

(Minerals density before demineralization - minerals density after demineralization) × 100

Criteria for evaluation of promotion effect

◎: Over 60%

○: The recall ratio is 50% or more and less than 60%

△: Residual painting rate is 30% or more and less than 50%

X: Less than 30%

(2) Evaluation method of demineralization inhibiting effect

The root portion of the umbrella was cut, the surface of the root portion was abraded with 300 times of sandpaper, followed by polishing with 1,500 times of sandpaper to form a flattened and dented dentin surface. This dentin sample piece was covered with a water resistant manicure except for a certain area (circle of 3 mm diameter, hereinafter abbreviated as test surface). This test surface was immersed for 3 minutes in a slurry obtained by diluting each dentifrice composition twice with water. Thereafter, the excess component was removed by washing with water, and 15 μl of an acid (0.6% acetic acid solution, pH 4.5) for dentin demineralization was added dropwise to the test surface, followed by demineralization for 30 minutes. Thereafter, this sample piece was put into 1 ml of distilled water together with 1 占 퐇 of acetic acid solution, and mineral ions dissolved in acetic acid were extracted by a demining operation. Subsequently, the sample piece was taken out of the distilled water, the excess water was removed, and the same treatment, demineralization and extraction of mineral ions were repeated twice. The concentration (ppm) of phosphoric acid in the mineral ions extracted and accumulated in 1 ml was measured using a vanadomolybdate method using absorbance. The test surface was immersed in water for 3 minutes to similarly measure the phosphoric acid concentration of the treated surface. The demineralization inhibition rate was calculated by the following formula and evaluated according to the following criteria.

[Equation 2]

(%) = (Phosphoric acid concentration after water treatment-phosphoric acid concentration after skimmed product treatment) /

(Phosphoric acid concentration after water treatment) x 100

Evaluation criterion of demineralization inhibition effect

&Amp; cir &: The demineralization inhibition rate is 70% or more

○: Delinquent inhibition rate is 50% or more and less than 70%

DELTA: Delinquent inhibition rate is 30% or more and less than 50%

X: Less than 30% of deliming inhibition rate

(3) Evaluation method of refreshing feeling

About 10 g of the subject's dentifrice composition was applied to a toothbrush, and about 3 g of the dentifrice was wiped for 3 minutes. The dentifrice was evaluated as having a good feeling of coolness of 4, a good feeling of coolness of 3, The feeling of no feeling of cooling was taken as 1 point, and the use feeling was evaluated based on the following criteria from the average of 10 persons.

Evaluation criteria of refreshing feeling

◎: Average point 3.5 points or more and 4.0 points or less

○: Average point 3.0 points or more and less than 3.5 points

△: average point is 2.0 or more and less than 3.0 point

×: Average point 1.0 point or more and less than 2.0 points

[Table 1]

[Table 2]

[Table 3]

[Table 4]

Claims (12)

(A) fine calcium carbonate having an average primary particle diameter of 1 탆 or less,
(B) Highly polymerized polyethylene glycol
By weight of the composition. The method according to claim 1,
Wherein the highly polymerized polyethylene glycol as the component (B) has an average molecular weight of 100,000 or more. The method according to claim 1 or 2,
, 0.1 to 10 mass% of component (A), and 0.01 to 0.5 mass% of component (B). The method according to claim 1, 2 or 3,
Wherein the component (A) / component (B) has a mass ratio of 0.2 to 1,000. 5. The method according to any one of claims 1 to 4,
And (C) erythritol. 6. The method of claim 5,
Wherein the composition has a water content of 25 mass% or less. 7. The method according to any one of claims 1 to 6,
And (D) a fluorine compound. 8. The method according to any one of claims 1 to 7,
The skirt composition according to any one of claims 1 to 3, further comprising a silica-based abrasive. (A) calcium carbonate fine granules having an average primary particle diameter of 1 탆 or less and (B) highly polymerized polyethylene glycol. 10. The method of claim 9,
Wherein the component (A) / component (B) is 0.2 to 1,000 in mass ratio. 11. The method according to claim 9 or 10,
Also, (C) a resorptive enhancer for teeth characterized by containing erythritol. (A) Use of fine calcium carbonate having an average primary particle diameter of 1 占 퐉 or less and (B) highly polymerized polyethylene glycol for producing a remineralization accelerator for teeth.