KR20170094133A - Composition for use in oral cavity - Google Patents

Abstract

[assignment]
(A) at least one water-soluble metal salt selected from a copper salt, a zinc salt and a tin salt, which can be suitably used for suppressing formation of plaque, by suppressing the metal taste or the sense of convergence by the water-soluble metal salt, (B) benzyl alcohol, and (C) xylitol and / or erythritol, wherein the ratio of (A) / (B) is 0.04 to 10 in mass ratio and the ratio of (A) / To provide an oral composition.

Description

COMPOSITION FOR USE IN ORAL CAVITY [0002]

The present invention relates to an oral composition containing a water-soluble metal salt, which is suitable for suppressing formation of plaque, suppressing metallic tastes and convergence feeling by the water-soluble metal salt and having excellent palatability.

Conventionally, it has been said that water-soluble metal salts such as copper salts, zinc salts and tin salts have an effect of suppressing the formation of plaques, and proposals have been made for their incorporation into oral compositions (Patent Literatures 1 to 3: 2010/113688, JP-A-2007-126421, JP-A-5-930).

However, there is a problem that the water-soluble metal salt has too strong a sense of convergence during use and has aftertaste of metal taste after use. Therefore, the composition for oral use containing a water-soluble metal salt has a drawback (Patent Document 2).

On the other hand, in oral compositions, it is known that benzyl alcohol is blended as a flavor component or as a preservative, and that benzyl alcohol has an antibacterial activity (Patent Documents 4 to 7: Japanese Patent Specification 2009 -531414, JP-A-2010-523551, JP-A-2013-540813, JP-A-2013-32371).

Patent Document 1: International Publication No. 2010/113688 Patent Document 2: Japanese Patent Application Laid-Open No. 2007-126421 Patent Document 3: JP-A-5-930 Patent Document 4: Japanese Patent Specification No. 2009-531414 Patent Document 5: Japanese Patent Application No. 2010-523551 Patent Document 6: Japanese Patent Specification No. 2013-540813 Patent Document 7: JP-A-2013-32371

Therefore, it was a problem to improve the palatability by suppressing the metal taste and the sense of convergence of the oral composition containing the water-soluble metal salt.

The object of the present invention is to provide an oral composition containing a water-soluble metal salt, which is suitable for suppressing formation of plaque, by suppressing the metal taste and the sense of convergence by the water-soluble metal salt and imparting excellent palatability.

The inventors of the present invention have conducted intensive studies in order to achieve the above object. As a result, the present inventors have found that by combining benzyl alcohol, xylitol and / or erythritol in a specific ratio in an oral composition containing a water-soluble metal salt, Effect.

(A) at least one water-soluble metal salt selected from the group consisting of (A) copper salts, zinc salts and tin salts, (B) benzyl alcohol, (C) xylitol and / or erythritol, (B) is 0.04 to 10 in mass ratio and (A) / (C) is 0.01 to 10 in mass ratio, the metal taste and the sense of convergence by the water-soluble metal salt as the component (A) are suppressed, And that the composition can be suitably used for suppressing the formation of plaques, and thus the present invention has been accomplished.

More specifically, the water-soluble metal salt of copper salt, zinc salt and tin salt has a plaque formation inhibiting action, but gives a sense of convergence and a metal taste, and also has a feeling of convergence to benzyl alcohol. On the other hand, (B) benzyl alcohol and (C) xylitol and / or erythritol in combination with water-soluble metal salt as the component (A), the metal taste is sufficiently suppressed while maintaining the plaque formation inhibiting effect , And the feeling of convergence is reduced, thereby giving excellent palatability. In this case, by using benzyl alcohol (B) in combination with the water-soluble metal salt as the component (A) in a specific range, the aftertaste of the metal taste is reduced after use, and after 5 minutes of use, (C) xylitol and / or erythritol in combination with the (A) / (C) ratio in the sugar alcohol in the specific range with respect to the component (A) And the specific action and effect can be given specifically.

It is also known from Patent Documents 4 to 7 that the combination of components (B) and (C) is a combination of components (A) and (B) It is unpredictable to specifically suppress taste and convergence.

In the present invention, the component (A) is preferably at least one water-soluble metal salt selected from among copper gluconate, zinc citrate and tin fluoride.

Accordingly, the present invention provides a method for inhibiting the metal taste and the sense of convergence of the water-soluble metal salt in the oral composition and oral composition described below.

[One]

(A) one or more water-soluble metal salts selected from copper salts, zinc salts and tin salts,

(B) benzyl alcohol, and

(C) xylitol and / or erythritol, wherein the mass ratio of (A) / (B) is 0.04 to 10, and (A) / (C) .

[2]

The oral composition according to [1], wherein the component (A) is at least one water-soluble metal salt selected from copper gluconate, copper citrate, zinc citrate, zinc gluconate, zinc chloride, tin fluoride and tin chloride.

[3]

The oral composition according to [1], wherein the component (A) is one or more water-soluble metal salts selected from copper gluconate, zinc citrate and tin fluoride.

[4]

(1), (2) or (3), wherein the composition contains 0.01 to 3 mass% of component (B) and 0.01 to 20 mass% of component (C).

[5]

The oral composition according to any one of [1] to [4], wherein the composition contains 0.01 to 2.6% by mass of the component (A).

[6]

The oral composition according to any one of [1] to [5], which is prepared as a skirt preparation.

[7]

(A) an oral composition containing one or more water-soluble metal salts selected from copper salts, zinc salts and tin salts,

(B) benzyl alcohol, and

(C) xylitol and / or erythritol are blended,

(A) in a composition for oral cavity, wherein the mass ratio of A) / (B) is 0.04 to 10, and the ratio of (A) / (C) Inhibition method.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide an oral composition containing a water-soluble metal salt suitable for suppressing formation of plaque, with the metal taste and the sense of convergence being suppressed by the water-soluble metal salt and imparting excellent palatability.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention is characterized by containing (A) at least one water-soluble metal salt selected from a copper salt, a zinc salt and a tin salt, (B) a benzyl alcohol, and (C) a xylitol and / , And the mass ratio of (A) / (B) and the mass ratio of (A) / (C), respectively.

The component (A) is a water-soluble metal salt selected from a copper salt, a zinc salt and a tin salt, and examples thereof include copper salts such as copper gluconate and copper citrate, zinc salts such as zinc citrate, zinc gluconate, Tin salts such as tin fluoride and tin chloride, and copper gluconate, zinc citrate, and tin fluoride are particularly suitable. These may be used singly or in combination of two or more in terms of effect expression. The preferred component (A) is a copper salt or a tin salt, and a copper salt is more preferable.

The blending amount of the water-soluble metal salt as the component (A) is preferably 0.01 to 2.6% (mass%, the same applies hereinafter), more preferably 0.02 to 2.6% of the entire composition. The greater the blending amount, the higher the plaque formation inhibiting effect, and when the blending amount is 0.01% or more, sufficient plaque formation inhibiting effect can be given. If it is 2.6% or less, it is possible to satisfactorily suppress the convergence feeling and the metal taste.

The water-soluble metal salt may be used singly or in combination of two or more in the range of the amount of the component (A), but the amount of the copper salt to be added to the entire composition as the amount of each metal salt is preferably 0.01 To 1%, the zinc salt content is preferably 0.4 to 2%, and the tin salt content is preferably 0.1 to 0.5%.

The blending amount of the benzyl alcohol as the component (B) is preferably from 0.01 to 3%, more preferably from 0.02 to 3%, and still more preferably from 0.02 to 1%, based on the whole composition. When the blending amount is 0.01% or more, the metal taste derived from the water-soluble metal salt can be sufficiently inhibited. When it is 3% or less, the appearance of convergence feeling derived from benzyl alcohol can be suppressed, and the feeling of convergence during use can be suppressed, and palatability can be maintained more appropriately.

The component (C) is xylitol and / or erythritol, and xylitol and erythritol may also be used from the viewpoint of effect development even when xylitol or erythritol is used.

The blending amount of the component (C) is preferably from 0.01 to 20%, more preferably from 0.02 to 13%, and still more preferably from 0.05 to 5% of the entire composition. If it is 0.01% or more, the sense of convergence can be further improved. If it is 20% or less, the metal taste derived from the water-soluble metal salt can be sufficiently inhibited. On the other hand, if it exceeds 20%, the metal taste derived from the water-soluble metal salt may be more strongly felt due to the sweetness derived from the component (C).

In the present invention, (A) / (B) representing the proportion of the components (A) and (B) is 0.04 to 10, preferably 0.1 to 8, and more preferably 0.1 to 5 in mass ratio. By combining the components (A) and (B) within the above range, the metal taste and the feeling of convergence can be suppressed and the palatability can be improved. When the ratio (A) / (B) is less than 0.04, the sense of convergence originating from benzyl alcohol is strongly felt, which is poor in palatability, and if it exceeds 10, the metal taste derived from the water-soluble metal salt can not be reduced to achieve the object of the present invention I can not.

In the present invention, (A) / (C), which represents the proportion of the components (A) and (C), is 0.01 to 10 mass%, more preferably 0.02 to 5 mass ratio. By combining the components (A) and (C) in combination within the above range, the metal taste and the feeling of convergence can be suppressed and the palatability can be improved. If it is less than 0.01, the taste of the metal from the water-soluble metal salt is more emphasized by the sweetness derived from the component (C), and the palatability is poor. If it exceeds 10, the feeling of convergence can not be reduced.

The oral composition of the present invention is suitably prepared especially as a dental agent such as a continuous skirt or a liquid skirt. Further, in addition to the above-mentioned components, other known components may be blended as needed within a range not hindering the effect of the present invention. For example, in a continuous skimming agent, an abrasive, a tackifier, a binder, a surfactant, and, if necessary, a sweetener, a colorant, an antiseptic, an antioxidant, and an active ingredient may be mixed. The compounding amount may be a usual amount within the range not hindering the effect of the present invention.

Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, and zirconosilicate, calcium phosphate-based compounds such as calcium phosphate dihydrate and anhydride, calcium phosphate monobasic and tribasic calcium phosphate, Calcium, calcium hydroxide, aluminum hydroxide, synthetic resin abrasive, zeolite, and alumina. The blending amount of the abrasive is usually 2 to 40%, particularly 10 to 30%.

Examples of the viscosifier include polyhydric alcohols such as glycerin, propylene glycol and polyethylene glycol, and sorbitol. The blending amount of these viscous agents is usually 5 to 50%, particularly 20 to 45%.

Examples of the binder include cellulose derivatives such as sodium carboxymethylcellulose, rubbers such as carboxymethylcellulose, alginic acid derivatives such as sodium alginate, organic binders such as carrageenan, synthetic binders such as carbobole, Gelling inorganic silica, non-rubber, and laponite. The blending amount is usually 0.1 to 10%, particularly 0.5 to 3%.

As the surfactant, anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants can be mixed.

Examples of the anionic surfactant include alkylsulfuric acid salts such as sodium laurylsulfate, N-acylsalcosinates such as N-lauroylsalcosine, and N-acylglutamates.

Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid esters and sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene Polyoxyethylene fatty acid esters such as hydrogenated castor oil, polyoxyethylene higher alcohol ethers and fatty acid alkanolamides.

Examples of the cationic surfactant include alkylammonium type and alkylbenzylammonium salt. Examples of the amphoteric surfactant include fatty acid amide propyl betaine, betaine acetate, and imidazoline.

The blending amount of the surfactant is preferably 0.01 to 10%, particularly 0.01 to 5%.

Examples of the sweetener include sodium saccharin, acesulfame K and sucralose. Examples of the colorant include red No. 2, blue No. 1, titanium oxide and the like.

Examples of the preservative include paraoxybenzoic acid esters such as methylparaben, benzoic acid or salts thereof, and the like.

Examples of the flavoring agent include those selected from the group consisting of peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, time oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, Lavender oil, Rosemary oil, Lorrach oil, Camomile oil, Caraway oil, Marjoram oil, Bayou, Lemon grass oil, Oriental oil, Pine needle oil, Neroli oil, Rose oil, Jasmine oil, Grapefruit oil, Sweet oil, (Such as free cutting, iris concrete, Absolute Peppermint, Absolute Rose, orange flower, etc.), processing of these natural fats (cutting of the current portion, cutting of the wake portion, ) Extract, an essence, a powdery preparation, and the like) and one or more agents selected from the group consisting of menthol, carboen, anethole, cineol, methyl salicylate, cinnamic aldehyde, ogenol, 3-l-menthoxypropane- Diol, thymol, linalool, linalyl acetate, limonene, menton, menthyl acetate, N - substituted-parramentane-3-carboxamide, pinene, octylaldehyde, citral, fullergan, carvir acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, Ethylhexanoate, ethylmethylphenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate and the like Such as the combination of strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fructus mix flavor, tropical fruct flavor and the like, The materials may be used in combination, but the present invention is not limited to the examples described in the Examples.

The blending amount is not particularly limited, but it is preferable to use 0.000001 to 1% of the above-mentioned antibacterial material in the formulation composition. In addition, it is preferable that 0.1 to 2% of the composition be used as an excipient for the use of the above-mentioned antimicrobial material.

Examples of the active ingredient include those conventionally compounded in the composition for oral cavity such as a sterilizing agent such as triclosan, isopropylmethylphenol, cetylpyridinium chloride and benzethonium chloride, an anti-inflammatory agent such as tranexamic acid, allantoin, , An enzyme such as dextranase, a sodium salt of fluoride such as sodium fluoride, sodium monofluorophosphate, aluminum lactate, arginine, phosphoric acid, plant extract or the like can be added in an effective amount to the extent that the effect of the present invention is not hindered .

Example

Hereinafter, examples and comparative examples will be shown and the present invention will be described in detail, but the present invention is not limited to the following examples. In the following examples,% represents mass% unless otherwise specified.

[Practical example, comparative example]

The compositions for oral use (compositions for the preparation of dentifrices) having the compositions shown in Tables 1 to 3 were prepared by a routine method and evaluated by the following methods. The results are listed in the table.

<Evaluation method>

(1) Evaluation of aftertaste of metal taste after use

The metal taste felt in the mouth after the lapse of 5 minutes after the mouth was rinsed after brushing for 3 minutes was applied to a toothbrush (three lines of Kurinika toothbrush, hardness: normal) . The average score of 10 persons was evaluated according to the following criteria, and the aftertaste of the metal taste after use was indicated in the table as?,?,?, And?.

Criteria

5: I do not feel metal taste

4: I feel a little bit of metallic taste.

3: I feel metal taste

2: I feel strong metal taste

1: I feel very strong metal taste

Evaluation standard

◎: Average point 4.5 points or more and 5.0 points or less

○: Average point 4.0 points or more and less than 4.5 points

△: Average point 3.0 or more and less than 4.0 point

X: Average point 1.0 point or more and less than 3.0 point

(2) Evaluation of convergence feeling during use

0.5 g of a dental skirt was put on a toothbrush, and the degree of convergence in the mouth was measured at the time of brushing. Averages of 10 persons were evaluated according to the following criteria, and the degree of convergence during use was indicated in the table as?,?,?, And?.

Criteria

5: I do not feel a sense of convergence

4: I feel a little bit of a sense of convergence

3: I feel a sense of convergence

2: I feel strong sense of convergence

1: I feel very strongly the sense of convergence

Evaluation standard

◎: Average point 4.5 points or more and 5.0 points or less

○: Average point 4.0 points or more and less than 4.5 points

△: Average point 3.0 or more and less than 4.0 point

X: Average point 1.0 point or more and less than 3.0 point

Details of the raw materials used are shown below.

(A) Copper copper gluconate: Copper copper gluconate made by Kanto Kagaku Co., Ltd.

 Zinc citrate: Zinc citrate made by Kanto Kagaku Co., Ltd.

 Tin fluoride: tin fluoride manufactured by Junsei Chemical Co., Ltd.

(B) Benzyl alcohol: tin fluoride manufactured by Junsei Chemical Co., Ltd.

(C) Xylitol: Zeoxyl Chemical Co., Ltd. xylitol

 Erythritol: Erythritol manufactured by Junsei Chemical Co., Ltd.

[Table 1]

[Table 2]

[Table 3]

As shown in Table 3, when the ratio of (A) / (B) or (A) / (C) is inadequate, even when components (B) and (C) (A), (B), and (A) / (B) ratio as shown in Tables 1 and 2, ) / (C) ratio within a proper range, the aftertaste of the metal taste and the feeling of convergence were suppressed and the palatability was excellent. Therefore, it was found that the oral compositions of these Examples are suitable for imparting the plaque formation inhibiting effect.

Claims (7)

(A) one or more water-soluble metal salts selected from copper salts, zinc salts and tin salts,
(B) benzyl alcohol, and
(C) containing xylitol and / or erythritol,
(A) / (B) is 0.04 to 10 in mass ratio, and (A) / (C) is in a mass ratio of 0.01 to 10. The method according to claim 1,
Wherein the component (A) is one or more water-soluble metal salts selected from copper gluconate, copper citrate, zinc citrate, zinc gluconate, zinc chloride, tin fluoride and tin chloride. The method according to claim 1,
Wherein the component (A) is one or more water-soluble metal salts selected from copper gluconate, zinc citrate and tin fluoride. 4. The method according to any one of claims 1 to 3,
(B) in an amount of 0.01 to 3 mass%, and (C) in an amount of 0.01 to 20 mass%. 5. The method according to any one of claims 1 to 4,
(A) is contained in an amount of 0.01 to 2.6% by mass. 6. The method according to any one of claims 1 to 5,
Wherein the composition is prepared as a skirt preparation. (A) an oral composition containing one or more water-soluble metal salts selected from copper salts, zinc salts and tin salts,
(B) benzyl alcohol, and
(C) xylitol and / or erythritol are blended,
(A) / (B) in the composition for oral cavity characterized by the ratio of (A) / (B) being 0.04 to 10 in mass ratio and the ratio of (A) / And a method for suppressing convergence.