JP2020011951A - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP2020011951A JP2020011951A JP2019119632A JP2019119632A JP2020011951A JP 2020011951 A JP2020011951 A JP 2020011951A JP 2019119632 A JP2019119632 A JP 2019119632A JP 2019119632 A JP2019119632 A JP 2019119632A JP 2020011951 A JP2020011951 A JP 2020011951A
- Authority
- JP
- Japan
- Prior art keywords
- feeling
- oral composition
- component
- washing
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 80
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims abstract description 33
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940043350 citral Drugs 0.000 claims abstract description 17
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims abstract description 17
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960005233 cineole Drugs 0.000 claims abstract description 16
- 229940087305 limonene Drugs 0.000 claims abstract description 16
- 235000001510 limonene Nutrition 0.000 claims abstract description 16
- 229940116257 pepper extract Drugs 0.000 claims abstract description 15
- -1 2-pyridinyl Chemical group 0.000 claims description 34
- 239000000551 dentifrice Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 229930007050 cineol Natural products 0.000 claims description 12
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 claims description 9
- 230000035597 cooling sensation Effects 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 239000002324 mouth wash Substances 0.000 claims description 6
- 229940051866 mouthwash Drugs 0.000 claims description 6
- FINKDHKJINNQQW-UHFFFAOYSA-N 5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical class CC(C)C1CCC(C)CC1C(N)=O FINKDHKJINNQQW-UHFFFAOYSA-N 0.000 claims description 5
- FPJRGEOLQICYQZ-UHFFFAOYSA-N n-[4-(cyanomethyl)phenyl]-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(=O)NC1=CC=C(CC#N)C=C1 FPJRGEOLQICYQZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 4
- QRYKPMDEGMJHAT-UHFFFAOYSA-N 1-ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CCC1(C(N)=O)CC(C)CCC1C(C)C QRYKPMDEGMJHAT-UHFFFAOYSA-N 0.000 claims 1
- 238000005406 washing Methods 0.000 abstract description 34
- 230000035807 sensation Effects 0.000 abstract description 11
- 244000089698 Zanthoxylum simulans Species 0.000 abstract description 5
- 235000009932 Zanthoxylum simulans Nutrition 0.000 abstract description 4
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 abstract description 4
- 230000009172 bursting Effects 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 30
- 235000019640 taste Nutrition 0.000 description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
- 239000000796 flavoring agent Substances 0.000 description 16
- 235000019634 flavors Nutrition 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 239000003205 fragrance Substances 0.000 description 15
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 239000000284 extract Substances 0.000 description 14
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 11
- 239000004359 castor oil Substances 0.000 description 11
- 235000019438 castor oil Nutrition 0.000 description 11
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 11
- 235000002639 sodium chloride Nutrition 0.000 description 11
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 10
- 235000019615 sensations Nutrition 0.000 description 10
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 238000005187 foaming Methods 0.000 description 9
- 229940041616 menthol Drugs 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 8
- 235000019658 bitter taste Nutrition 0.000 description 7
- 238000013329 compounding Methods 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 239000000377 silicon dioxide Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000006260 foam Substances 0.000 description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 4
- 235000002566 Capsicum Nutrition 0.000 description 4
- 206010015535 Euphoric mood Diseases 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 4
- 239000003945 anionic surfactant Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229940085605 saccharin sodium Drugs 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 235000013599 spices Nutrition 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 239000000811 xylitol Substances 0.000 description 4
- 235000010447 xylitol Nutrition 0.000 description 4
- 229960002675 xylitol Drugs 0.000 description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 4
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- 206010013911 Dysgeusia Diseases 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000006002 Pepper Substances 0.000 description 3
- 235000016761 Piper aduncum Nutrition 0.000 description 3
- 240000003889 Piper guineense Species 0.000 description 3
- 235000017804 Piper guineense Nutrition 0.000 description 3
- 235000008184 Piper nigrum Nutrition 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 241001093501 Rutaceae Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 235000019629 palatability Nutrition 0.000 description 3
- 208000028169 periodontal disease Diseases 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000010356 sorbitol Nutrition 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- DORBKQIZZTWKOR-UHFFFAOYSA-N 2-(2-oxotridecylamino)ethanesulfonic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(=O)CNCCS(O)(=O)=O DORBKQIZZTWKOR-UHFFFAOYSA-N 0.000 description 2
- UWKAYLJWKGQEPM-UHFFFAOYSA-N 3,7-dimethylocta-1,6-dien-3-yl acetate Chemical compound CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 2
- WXABJFUNSDXVNH-UHFFFAOYSA-N 5-methyl-2-propan-2-yl-n-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(=O)NCCC1=CC=CC=N1 WXABJFUNSDXVNH-UHFFFAOYSA-N 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 235000011203 Origanum Nutrition 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Natural products NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940011037 anethole Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960003720 enoxolone Drugs 0.000 description 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- VAMXMNNIEUEQDV-UHFFFAOYSA-N methyl anthranilate Chemical compound COC(=O)C1=CC=CC=C1N VAMXMNNIEUEQDV-UHFFFAOYSA-N 0.000 description 2
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 2
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- IAEGWXHKWJGQAZ-UHFFFAOYSA-N trimethylpyrazine Chemical compound CC1=CN=C(C)C(C)=N1 IAEGWXHKWJGQAZ-UHFFFAOYSA-N 0.000 description 2
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- NZGWDASTMWDZIW-MRVPVSSYSA-N (+)-pulegone Chemical compound C[C@@H]1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-MRVPVSSYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- FPJRGEOLQICYQZ-FHLIZLRMSA-N (1r,2s,5r)-n-[4-(cyanomethyl)phenyl]-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)NC1=CC=C(CC#N)C=C1 FPJRGEOLQICYQZ-FHLIZLRMSA-N 0.000 description 1
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 1
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- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
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- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、口腔内で泡がはじけるような独特な感覚によって高い洗浄実感を与える口腔用組成物に関する。 TECHNICAL FIELD The present invention relates to an oral composition which gives a high feeling of cleansing by a unique sensation such as foam popping in the oral cavity.
歯磨剤等の口腔用組成物において、使用時や使用後に口腔内が洗浄され、さっぱりしたと満足に実感できる効果感を与えることは、継続使用を促し日常的な歯周病、口臭等の予防又は抑制にも繋がり、効果向上を期待することもできる。このような観点から、口腔用組成物の使用者に、より一層満足してもらえるよう、洗浄実感等の効果感を更に改善して嗜好性の高い口腔用組成物を開発することが望まれる。 In oral compositions such as dentifrices, the oral cavity is washed at the time of use or after use, and gives a feeling of effect that can be satisfactorily realized when refreshed, which promotes continuous use and prevents daily periodontal disease, bad breath, etc. Alternatively, it leads to suppression, and an improvement in effect can be expected. From such a viewpoint, it is desired to develop an oral composition having a high palatability by further improving the feeling of effect such as a feeling of cleaning so that users of the oral composition can be more satisfied.
口腔用組成物に用いられる香料成分には、使用時や使用後のさっぱり感付与のためにメントールや冷感剤等が配合されているが、苦味や刺激を伴う場合や、さっぱり感が不十分な場合もあった。
また、香辛料成分であるスピラントール、トウガラシ等を香料成分として配合することにより、収斂感や辛味、苦味等の味的刺激の感覚を与えることで、さっぱり感を補強し、口腔用組成物に配合されている薬効を与える各種有効成分の効果感を演出できることが知られているが、これら香料成分には刺激や苦味が強いものもあり、歯周病予防等の薬用タイプの製品に限られることが多かった。
The fragrance component used in the oral composition contains menthol or a cooling sensation agent or the like for the purpose of providing a refreshing feeling at the time of use or after use. There were cases.
Also, by blending spice ingredients such as spirantol and capsicum as flavor ingredients, it gives a feeling of taste stimulus such as astringency, pungency, and bitterness. Although it is known that various active ingredients that give medicinal effects can produce a sense of effectiveness, some of these flavor ingredients have a strong irritation and bitterness, and are limited to medicinal products such as periodontal disease prevention. There were many.
特許文献1(特許第5251350号公報)は、メントール等の清涼感付与剤及び特定の冷感付与剤と塩化ナトリウム等とを組み合わせて配合することで、清涼感を向上し、苦味や嫌味を抑制できること、更にスピラントール、唐辛子等を添加すると苦味や嫌味がより和らぐことを提案している。特許文献2(特許第5748626号公報)では、口腔用組成物に殺菌剤と共にサンショウエキス及びグアイアコール等を特定割合で配合すると、薬効感、効果感及び嫌味のマスキング性が改善し嗜好性も良好となることを提案している。特許文献3(特許第5897843号公報)は、特定の香辛料抽出物を含有する口腔用組成物、特にチューインガムに、ミント香料、メントール及びクーリングエンハンサーをそれぞれ特定量配合すると、ミントの味感及び爽やかさが持続することを提案している。特許文献4(特開2015−43769号公報)は、ヒドロキシ−α−サンショール及び/又は2−フェニルブタノールを含有する経口組成物、好ましくはチューインガムやキャンディーが、唾液分泌効果、湿潤効果等に優れることを提案している。 Patent Literature 1 (Japanese Patent No. 5251350) discloses a combination of a refreshing agent such as menthol or a specific cooling agent and sodium chloride to improve the refreshing feeling and suppress bitterness and disgust. It proposes that what can be done, and that the addition of spirantol, chili, etc. will further reduce bitterness and hate. In Patent Literature 2 (Japanese Patent No. 5748626), when a composition for oral cavity is mixed with a fungicide and a sansho extract, guaiacol, and the like at a specific ratio, the medicinal effect, the effect, and the masking property of unpleasant taste are improved, and the palatability is also good. It is proposed to be. Patent Document 3 (Japanese Patent No. 5879784) discloses that when a specific amount of a mint flavor, menthol, and a cooling enhancer are added to an oral composition containing a specific spice extract, in particular, a chewing gum, the taste and freshness of mint are obtained. Is proposed to last. Patent Document 4 (Japanese Patent Application Laid-Open No. 2015-43969) discloses that an oral composition containing hydroxy-α-sanshoal and / or 2-phenylbutanol, preferably a chewing gum or a candy, is excellent in saliva secretion effect, moisturizing effect and the like. Propose that.
本発明は、上記事情に鑑みなされたもので、口腔内で泡がはじけるような独特な感覚によって高い洗浄実感を与える口腔用組成物を提供することを目的とする。 The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a composition for an oral cavity that gives a high feeling of cleansing by a unique sensation such as foam popping in the oral cavity.
本発明者は、上記目的を達成するため鋭意検討を行った結果、(A)シチュアンペッパー抽出物と、(B)シネオールと、(C)(C1)シトラール及び(C2)リモネンから選ばれる1種以上とを組み合わせて口腔用組成物に配合すると、口腔内で泡がはじけるような独特な感覚によって高い洗浄実感を付与することができ、また、嫌味が抑制されて味も良いことを知見し、本発明をなすに至った。 The present inventor has conducted intensive studies to achieve the above object, and as a result, (A) 1 selected from (C) (C1) citral and (C2) limonene, (C) (C1) citral, and (B) cineole. When combined with a composition for oral cavity in combination with more than one species, it is possible to impart a high feeling of washing by a unique feeling such as foam popping in the oral cavity, and it is also found that the unpleasant taste is suppressed and the taste is good. The present invention has been accomplished.
更に詳述すると、本発明では、(A)、(B)及び(C)成分を組み合わせた香料組成によって、口腔用組成物を使用時に口に含んだときに口腔内で泡がはじけるような、例えば一般的な界面活性剤による起泡ではなく、いわゆる炭酸発泡のような独特な感覚(発泡感)が感じられ、しかも、前記感覚が使用後に口を濯いでも持続し、このような特異な発泡感覚によって、口腔内が洗浄されたように感じられる効果感を与えることができた。また、(A)、(B)及び(C)成分は、それぞれ刺激や苦味等を有するが、(A)、(B)及び(C)成分を組み合わせることで、各香料成分による上記不快な味等を嫌味として感じさせることなく抑制し、嫌味のない良い味を与えることもできた。
本発明では、更に(D)冷感剤を添加すると、特に使用後の上記洗浄実感をより向上することもできた。
本発明の口腔用組成物は、従来のメントール等の清涼感付与成分によるさっぱり感や効果感とは異なる、上記特有な発泡感覚によって高い洗浄実感を与え、味も良いことから、高い嗜好性を期待できる。
後述の比較例の結果からも明らかなように、本発明にかかわる(A)、(B)及び(C)成分のうちのいずれかを含まないと、使用中及び使用後の洗浄実感(発泡感)が弱く、口腔用香料として一般的な清涼感を与えるメントール、更にはエタノールを含有していても上記のように洗浄実感が弱く、劣った(比較例1〜9)。これに対して、実施例に示すように、本発明の(A)、(B)及び(C)成分を含有する口腔用組成物(実施例1〜44)は、使用中及び使用後の洗浄実感が優れ、嫌味のなさも優れていた。
More specifically, in the present invention, the fragrance composition combining the components (A), (B) and (C) causes foam to burst in the oral cavity when the oral composition is contained in the mouth at the time of use. For example, instead of foaming with a general surfactant, a unique sensation (foaming sensation) such as so-called carbonated foaming is felt, and the sensation persists even after rinsing the mouth after use, and such a unique feeling is obtained. By the foaming sensation, it was possible to give an effect feeling as if the inside of the mouth was washed. Further, the components (A), (B) and (C) have irritation and bitterness, respectively, but by combining the components (A), (B) and (C), the unpleasant taste due to each flavor component is obtained. And the like were suppressed without being felt as unpleasant, and a good taste without any unpleasant taste could be given.
In the present invention, by further adding (D) a cooling sensation agent, it was possible to further improve the above-mentioned washing feeling particularly after use.
The oral composition of the present invention gives a high washing feeling by the above-mentioned unique foaming sensation, which is different from a refreshing feeling and a feeling of effect by a conventional refreshing ingredient such as menthol, and has a good taste, so that it has high palatability. Can be expected.
As is clear from the results of the comparative examples described below, if any one of the components (A), (B) and (C) according to the present invention is not contained, the washing feeling during use and after use (foaming feeling) ) Is weak, and even if it contains menthol, which gives a general refreshing sensation as an oral fragrance, and further contains ethanol, the washing feeling is weak and inferior as described above (Comparative Examples 1 to 9). On the other hand, as shown in the examples, the oral compositions containing the components (A), (B) and (C) of the present invention (Examples 1 to 44) were washed during and after use. The feeling was excellent and the tastelessness was also excellent.
従って、本発明は、下記の口腔用組成物を提供する。
〔1〕
(A)シチュアンペッパー抽出物、
(B)シネオール
及び
(C)(C1)シトラール及び(C2)リモネンから選ばれる1種以上
を含有する口腔用組成物。
〔2〕
(B)/(A)が質量比として0.2〜500である〔1〕に記載の口腔用組成物。
〔3〕
(C)成分として(C1)成分を含有する場合、(C1)/(A)が質量比として0.01〜50であり、(C2)成分を含有する場合、(C2)/(A)が質量比として1〜3,000である〔1〕又は〔2〕に記載の口腔用組成物。
〔4〕
(A)成分の含有量が純分として0.001〜0.1質量%である〔1〕〜〔3〕のいずれかに記載の口腔用組成物。
〔5〕
(B)成分の含有量が0.01〜2質量%である〔1〕〜〔4〕のいずれかに記載の口腔用組成物。
〔6〕
(C1)成分を含有する場合、その含有量が0.001〜0.2質量%であり、(C2)成分を含有する場合、その含有量が0.05〜10質量%である〔1〕〜〔5〕のいずれかに記載の口腔用組成物。
〔7〕
更に、(D)冷感剤を0.001〜2質量%含有する〔1〕〜〔6〕のいずれかに記載の口腔用組成物。
〔8〕
(D)冷感剤が、N−エチル−p−メンタン−3−カルボキサミド、N−(4−シアノメチルフェニル)−2−イソプロピル−5−メチルシクロヘキサンカルボキサミド及びN−(2−(2−ピリジニル)エチル)−2−イソプロピル−5−メチルシクロヘキサンカルボキサミドから選ばれる1種以上のp−メンタン−3−カルボキサミド類である〔7〕に記載の口腔用組成物。
〔9〕
更に、(E)界面活性剤を0.1〜5質量%含有する〔1〕〜〔8〕のいずれかに記載の口腔用組成物。
〔10〕
歯磨剤、洗口剤又はマウススプレー剤である〔1〕〜〔9〕のいずれかに記載の口腔用組成物。
Accordingly, the present invention provides the following oral composition.
[1]
(A) situ pepper extract,
An oral composition comprising (B) cineol and (C) one or more selected from (C1) citral and (C2) limonene.
[2]
The oral composition according to [1], wherein (B) / (A) has a mass ratio of 0.2 to 500.
[3]
When the component (C1) is contained as the component (C), the mass ratio of (C1) / (A) is 0.01 to 50, and when the component (C2) is contained, (C2) / (A) is The oral composition according to [1] or [2], which has a mass ratio of 1 to 3,000.
[4]
The oral composition according to any one of [1] to [3], wherein the content of the component (A) is 0.001 to 0.1% by mass as a pure component.
[5]
The oral composition according to any one of [1] to [4], wherein the content of the component (B) is 0.01 to 2% by mass.
[6]
When the component (C1) is contained, the content is 0.001 to 0.2% by mass, and when the component (C2) is contained, the content is 0.05 to 10% by mass [1]. The composition for oral cavity according to any one of to [5].
[7]
The oral composition according to any one of [1] to [6], further comprising (D) 0.001 to 2% by mass of a cooling sensation agent.
[8]
(D) N-ethyl-p-menthan-3-carboxamide, N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide and N- (2- (2-pyridinyl) The composition for oral cavity according to [7], which is one or more p-menthan-3-carboxamides selected from ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide.
[9]
The oral composition according to any one of [1] to [8], further comprising (E) 0.1 to 5% by mass of a surfactant.
[10]
The oral composition according to any one of [1] to [9], which is a dentifrice, mouthwash or mouth spray.
本発明によれば、口腔内で泡がはじけるような独特な感覚によって高い洗浄実感を与え、また、嫌味が抑制されて味も良い口腔用組成物を提供できる。前記口腔用組成物は、上記洗浄実感によって満足な効果感を与え、多種多様な用途の口腔製品使用者の嗜好を捉えるものと期待でき、特に歯肉炎等の歯周病ケアや口臭予防の用途に好適である。 Advantageous Effects of Invention According to the present invention, it is possible to provide an oral composition that gives a high feeling of washing by a unique sensation such as foam popping in the oral cavity and suppresses unpleasantness and has a good taste. The oral composition gives a satisfactory effect by the above-mentioned feeling of cleaning, and can be expected to capture the tastes of oral product users of various uses, especially for periodontal disease care such as gingivitis and prevention of bad breath. It is suitable for.
以下、本発明につき更に詳述する。本発明の口腔用組成物は、(A)シチュアンペッパー抽出物、(B)シネオール、及び(C)(C1)シトラール及び(C2)リモネンから選ばれる1種以上を含有する。本発明では、口腔用組成物において、香料成分である(A)、(B)及び(C)成分の組み合わせが洗浄実感付与剤として作用する。
本発明において、「洗浄実感」とは、口に含んだとき口腔内で泡がはじけるような感覚(発泡感)によって口腔内が洗浄されたように感じられる実感である(以下同様)。
Hereinafter, the present invention will be described in more detail. The oral composition of the present invention contains (A) situ pepper extract, (B) cineol, and (C) one or more kinds selected from (C1) citral and (C2) limonene. In the present invention, in the oral cavity composition, a combination of the perfume components (A), (B) and (C) acts as a cleansing feeling imparting agent.
In the present invention, the “cleaning feeling” is a feeling that the inside of the mouth is washed by a feeling (foaming feeling) that bubbles pop in the mouth when contained in the mouth (the same applies hereinafter).
(A)シチュアンペッパー抽出物の原料となるシチュアンペッパーは、一般的には花椒の別名で知られ、中国のミカン科サンショウ属の落葉低木である華北山椒(学名:Zanthoxylum bungeanum、英名:Sichuan pepper)の果皮を乾燥させたものを使用することができる。シチュアンペッパー抽出物としては、上記原料を使用し、公知の方法で得られる精油、エキス等の抽出物を使用でき、例えば、市販の水蒸気蒸留による精油や、二酸化炭素を用いた超臨界抽出物が挙げられる。中でも、洗浄実感の点で、二酸化炭素を用いた超臨界抽出物が好ましい。
(A)成分としては、例えば、シャラボ(株)製のシチュアンペッパーアブソリュートCO2エキストラクト(商品名;SICHUAN PEPPER ABSOLUTE CO2 EXTRACT、純度100%品)を使用できる。
(A) Situan pepper, which is a raw material of the situ pepper extract, is generally known as peppermint, and is a deciduous shrub of the genus Rutaceae in China (Zanthoxylum bungeanum, scientific name: English name: The dried pericarp of Sichuan pepper can be used. As the situ pepper extract, using the above-mentioned raw materials, an essential oil obtained by a known method, an extract such as an extract can be used, for example, a commercially available essential oil by steam distillation, or a supercritical extract using carbon dioxide Is mentioned. Above all, a supercritical extract using carbon dioxide is preferable from the viewpoint of the feeling of washing.
As the component (A), for example, Sitian Pepper Absolute CO2 Extract (trade name; SICHUAN PEPPER ABSOLUTE CO2 EXTRACT, 100% purity) manufactured by Shalabo Co., Ltd. can be used.
なお、本発明では、ミカン科サンショウ属であってもシチュアンペッパーとは異種の植物、例えば日本で一般的なサンショウ(学名:Zanthoxylum piperitum)の抽出物は相応しくなく、このようなサンショウ抽出物を配合しても、(A)成分が配合されていないと洗浄実感が低く作用効果が劣るものであった。 In the present invention, an extract of a plant of the genus Rutaceae belonging to the genus Rutaceae, which is different from that of Situan pepper, for example, an extract of a common common salt in Japan (scientific name: Zantoxylum piperitum) is not suitable. Even when the extract was blended, if the component (A) was not blended, the washing feeling was low and the effect was inferior.
(A)シチュアンペッパー抽出物の配合量は、組成物全体の0.001〜0.1%(質量%、以下同様)が好ましく、より好ましくは0.01〜0.05%である。配合量が0.001%以上であると、十分な洗浄実感が得られる。0.1%以下であると、シチュアンペッパー抽出物自体の嫌味(刺激のある味)を十分に抑制できる。上記配合量は、シチュアンペッパー抽出物の純分量である(以下同様)。 (A) The compounding amount of the situ pepper extract is preferably 0.001 to 0.1% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.01 to 0.05%. When the amount is 0.001% or more, a sufficient washing feeling can be obtained. When the content is 0.1% or less, the bad taste (irritating taste) of the situ pepper extract itself can be sufficiently suppressed. The above compounding amount is a pure amount of the situ pepper extract (the same applies hereinafter).
(B)シネオールは、市販のシネオール、例えば(株)永廣堂本店製等の製品を使用できる。なお、(B)成分として、シネオールを含む精油、例えばユーカリ油、ローズマリー油等を用いることもできる。 As (B) cineol, commercially available cineole, for example, a product manufactured by Eikodo Head Office or the like can be used. In addition, as the component (B), an essential oil containing cineol, for example, eucalyptus oil, rosemary oil, or the like can be used.
(B)シネオールの配合量は、組成物全体の0.01〜2%が好ましく、より好ましくは0.1〜1%である。配合量が0.01%以上であると、十分な洗浄実感が得られる。2%以下であると、シネオール自体の嫌味(苦味)を十分に抑制できる。 (B) The content of cineol is preferably 0.01 to 2%, more preferably 0.1 to 1% of the whole composition. When the amount is 0.01% or more, a sufficient washing feeling can be obtained. When the content is 2% or less, the bad taste (bitterness) of cineole itself can be sufficiently suppressed.
(C)成分は、(C1)シトラール及び(C2)リモネンから選ばれ、(C1)又は(C2)成分でもよいが、(C1)及び(C2)成分を組み合わせて用いてもよい。
(C)成分は、市販のシトラール及び/又はリモネン、例えば長谷川香料(株)製、高砂香料工業(株)製等の製品を使用することができる。
なお、(C)成分として、シトラール及び/又はリモネンを含む精油、例えばレモン油、オレンジ油、グレープフルーツ油等を用いることもできる。
The component (C) is selected from (C1) citral and (C2) limonene, and may be the (C1) or (C2) component, or may be a combination of the (C1) and (C2) components.
As the component (C), commercially available citral and / or limonene, for example, products manufactured by Hasegawa Perfume Co., Ltd. and Takasago Perfumery Co., Ltd. can be used.
In addition, as the component (C), essential oils containing citral and / or limonene, for example, lemon oil, orange oil, grapefruit oil and the like can also be used.
(C)成分の配合量は下記範囲が好ましい。
(C1)シトラールを配合する場合、その配合量は、組成物全体の0.001〜0.2%が好ましく、より好ましくは0.005〜0.1%である。配合量が0.001%以上であると、十分な洗浄実感が得られる。0.2%以下であると、シトラール自体の嫌味(油っぽさ)を十分に抑制できる。
(C2)リモネンを配合する場合、その配合量は、組成物全体の0.05〜10%が好ましく、より好ましくは0.2〜5%である。配合量が0.05%以上であると、十分な洗浄実感が得られる。10%以下であると、リモネン自体の嫌味(油っぽさ)を十分に抑制できる。配合量が10%を超えると、液分離等が生じて外観安定性が低下する場合がある。
なお、(C)成分の好ましい総量は、(C1)及び/又は(C2)成分の上記配合量を合算した範囲である。
The compounding amount of the component (C) is preferably in the following range.
When (C1) citral is blended, its blending amount is preferably 0.001 to 0.2%, more preferably 0.005 to 0.1% of the whole composition. When the amount is 0.001% or more, a sufficient washing feeling can be obtained. When the content is 0.2% or less, the unpleasant taste (oiliness) of citral itself can be sufficiently suppressed.
When (C2) limonene is blended, its blending amount is preferably 0.05 to 10%, more preferably 0.2 to 5% of the whole composition. When the amount is 0.05% or more, a sufficient washing feeling can be obtained. When the content is 10% or less, the bad taste (oiliness) of limonene itself can be sufficiently suppressed. If the amount is more than 10%, liquid separation or the like may occur, and the appearance stability may decrease.
The preferable total amount of the component (C) is a range in which the above-mentioned amounts of the components (C1) and / or (C2) are combined.
本発明において、(A)成分と(B)成分との量比を示す(B)/(A)は、質量比として0.2〜500が好ましく、3〜100がより好ましい。この範囲内であると、洗浄実感が特に優れ、嫌味が十分に抑制され使用感もより優れる。(B)/(A)の質量比が0.2未満又は500を超えると、洗浄実感が低くなる場合がある。
また、(A)成分と(C)成分との量比は、(C)成分として(C1)シトラールを配合する場合は、(C1)/(A)が質量比として0.01〜50、特に0.1〜5が好ましく、また、(C2)リモネンを配合する場合は、(C2)/(A)が質量比として1〜3,000、特に1〜1,000、とりわけ5〜200が好ましい。それぞれ上記範囲内であると、洗浄実感が向上し、飛躍的に高い洗浄実感を付与することができ、嫌味をより抑制することもできる。(C1)/(A)の質量比が50を超えると、十分な洗浄実感が得られず嫌味の抑制効果も十分に得られない場合がある。また、(C2)成分量が多すぎて(C2)/(A)の質量比が3,000を超えると、液分離が生じる場合がある。
In the present invention, (B) / (A) indicating the quantitative ratio of the component (A) to the component (B) is preferably from 0.2 to 500, more preferably from 3 to 100 as a mass ratio. When the content is within this range, the feeling of actual cleaning is particularly excellent, the unpleasant taste is sufficiently suppressed, and the feeling of use is more excellent. When the mass ratio of (B) / (A) is less than 0.2 or more than 500, the feeling of actual cleaning may decrease.
Further, when the amount ratio of the component (A) to the component (C) is (C1) citral is blended as the component (C), the mass ratio of (C1) / (A) is 0.01 to 50, particularly 0.1-5 is preferable, and when (C2) limonene is mix | blended, (C2) / (A) has a mass ratio of 1-3,000, especially 1-1,000, especially 5-200. . When each of the amounts is within the above range, the washing feeling can be improved, a drastically high washing feeling can be given, and the unpleasant taste can be further suppressed. When the mass ratio of (C1) / (A) exceeds 50, sufficient washing feeling may not be obtained, and the effect of suppressing odor may not be sufficiently obtained. Further, if the amount of the component (C2) is too large and the mass ratio of the component (C2) / (A) exceeds 3,000, liquid separation may occur.
本発明では、更に、(D)冷感剤を配合することが好ましい。(D)冷感剤を配合すると、使用後の洗浄実感が向上し、特に洗浄実感の持続性がより優れる。
冷感剤は、メントール誘導体、p−メンタン−3−カルボキサミド類等を使用できる。具体的にメントール誘導体としては、メンチルラクテート、モノメンチルサクシネート、モノメンチルグルタレート、3−L−メントキシプロパン−1,2−ジオール等が挙げられ、p−メンタン−3−カルボキサミド類としては、N−エチル−p−メンタン−3−カルボキサミド、N−(4−シアノメチルフェニル)−2−イソプロピル−5−メチルシクロヘキサンカルボキサミド、N−(2−(2−ピリジニル)エチル)−2−イソプロピル−5−メチルシクロヘキサンカルボキサミド等が挙げられる。特にp−メンタン−3−カルボキサミド類が好ましい。これらは、1種単独でも2種以上を併用してもよい。
In the present invention, it is preferable to further mix (D) a cooling sensation agent. (D) When a cooling sensation agent is blended, the washing feeling after use is improved, and in particular, the persistence of the washing feeling is more excellent.
As the cooling sensation agent, menthol derivatives, p-menthan-3-carboxamides and the like can be used. Specific examples of the menthol derivative include menthyl lactate, monomenthyl succinate, monomenthyl glutarate, 3-L-menthoxypropane-1,2-diol, and the like.Examples of p-menthane-3-carboxamides include: N-ethyl-p-menthan-3-carboxamide, N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5 -Methylcyclohexanecarboxamide and the like. Particularly, p-menthan-3-carboxamides are preferred. These may be used alone or in combination of two or more.
冷感剤は、市販品を用いることができる。例えば、N−エチル−p−メンタン−3−カルボキサミド(ジボダンジャパン(株)製のWS−3)、N−(4−シアノメチルフェニル)−2−イソプロピル−5−メチルシクロヘキサンカルボキサミド(ジボダンジャパン(株)製のEvercool G−180)、N−(2−(2−ピリジニル)エチル)−2−イソプロピル−5−メチルシクロヘキサンカルボキサミド(ジボダンジャパン(株)製のEvercool G−190)を使用できる。 As the cooling sensation agent, a commercially available product can be used. For example, N-ethyl-p-menthan-3-carboxamide (WS-3 manufactured by Dibodan Japan KK), N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (Dibodan Japan KK ), N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide (Evercool G-190, manufactured by Divadan Japan K.K.).
(D)冷感剤の配合量は、組成物全体の0.001〜2%が好ましく、より好ましくは0.01〜1%である。配合量が0.001%以上であると、使用後も洗浄実感が十分に持続し、2%以下であると、十分に嫌味(苦味)が抑制され、香味発現性も良い。 (D) The content of the cooling sensation agent is preferably 0.001 to 2%, more preferably 0.01 to 1% of the whole composition. When the amount is 0.001% or more, the actual feeling of washing is sufficiently maintained even after use, and when the amount is 2% or less, the unpleasant taste (bitterness) is sufficiently suppressed and the flavor expression is good.
本発明の口腔用組成物は、更に、(E)界面活性剤を配合できる。
界面活性剤としては、アニオン性界面活性剤、ノニオン性界面活性剤、カチオン性界面活性剤、両イオン性界面活性剤が挙げられる。具体的には下記に示すものを、1種単独で又は2種以上を組み合わせて使用できる。
The oral composition of the present invention may further contain (E) a surfactant.
Examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and a zwitterionic surfactant. Specifically, the following compounds can be used alone or in combination of two or more.
アニオン性界面活性剤:
ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム等のアルキル硫酸塩;ラウロイルメチルタウリン等のアシルタウリン又はその塩;ラウリルスルホ酢酸ナトリウム;α−オレフィンスルホン酸塩;ラウロイルサルコシンナトリウム等のアシルサルコシン酸塩;ラウロイルグルタミン酸ナトリウム等のアシルアミノ酸塩
ノニオン性界面活性剤:
ポリオキシエチレン硬化ヒマシ油等のポリオキシエチレン脂肪酸エステル;ポリオキシエチレンラウリルエーテル、ポリオキシエチレンセチルエーテル等のポリオキシエチレン高級アルコールエーテル;ショ糖脂肪酸エステル等の糖脂肪酸エステル、糖アルコール脂肪酸エステル、ソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル
カチオン性界面活性剤:
塩化ジステアリルメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム
両イオン性界面活性剤:
2−アルキル−N−カルボキシメチル−N−ヒドロキシエチルイミダゾリニウムベタイン、脂肪酸アミドプロピルベタイン等のベタイン系
Anionic surfactant:
Alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate; acyl taurine such as lauroylmethyl taurine or a salt thereof; sodium lauryl sulfoacetate; α-olefin sulfonate; acyl sarcosinates such as sodium lauroyl sarcosine; sodium lauroyl glutamate; Nonionic surfactant of acyl amino acid salt of:
Polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil; polyoxyethylene higher alcohol ethers such as polyoxyethylene lauryl ether and polyoxyethylene cetyl ether; sugar fatty acid esters such as sucrose fatty acid esters; sugar alcohol fatty acid esters; sorbitan Fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester cationic surfactant:
Distearyl methyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride amphoteric surfactant:
Betaines such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and fatty acid amidopropyl betaine
アニオン性界面活性剤としては、特にアシルタウリン又はその塩、とりわけ;ラウロイルメチルタウリン塩が好ましい。
ノニオン性界面活性剤としては、特にポリオキシエチレン硬化ヒマシ油が好ましい。なお、ポリオキシエチレン硬化ヒマシ油のエチレンオキサイドの平均付加モル数は3〜200、特に20〜100が好ましい。
これらの中でも、アニオン性界面活性剤及びノニオン性界面活性剤が好ましく、特に、界面活性剤の泡による洗浄実感の補強効果が期待できる点から、ノニオン性界面活性剤、とりわけポリオキシエチレン硬化ヒマシ油が、より好ましい。
(E)界面活性剤の配合量は、組成物全体の0.1〜5%が好ましく、より好ましくは0.5〜3%である。
As anionic surfactants, in particular, acyltaurine or a salt thereof, especially; lauroylmethyltaurine salt is preferred.
As the nonionic surfactant, polyoxyethylene hydrogenated castor oil is particularly preferred. The average number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is preferably from 3 to 200, particularly preferably from 20 to 100.
Among these, anionic surfactants and nonionic surfactants are preferable, and in particular, nonionic surfactants, especially polyoxyethylene hydrogenated castor oil, can be expected from the point that the effect of enhancing the feeling of cleaning by surfactant foam can be expected. Is more preferred.
(E) The compounding amount of the surfactant is preferably from 0.1 to 5%, more preferably from 0.5 to 3% of the whole composition.
本発明の口腔用組成物は、ペースト状、液体等の形態で、練歯磨、液体歯磨、潤製歯磨等の歯磨剤、洗口剤、マウススプレー剤に調製することができ、特に歯磨剤又は洗口剤、とりわけ歯磨剤として好適である。
また、必要に応じて、上記成分に加えて、剤型に応じた他の公知の添加剤を本発明の効果を妨げない範囲で配合できる。例えば、研磨剤、粘稠剤、粘結剤、甘味剤、防腐剤、各種有効成分、着色剤、pH調整剤、香料等を配合することができ、これら成分と水とを混合して製造することができる。
なお、本発明では、エタノールが配合されていてもよいが無配合でもよく、エタノールの含有量は組成物全体の0〜50%がよく、3〜40%でもよい。口腔用組成物では、組成物中に配合される香料等にエタノールが微量含まれる場合があり、このようなエタノール以外にエタノールは配合しなくてもよく、この場合、エタノールの含有量は1%以下、特に0.5%以下、更には0.3%以下でもよい。
The oral composition of the present invention can be prepared in the form of paste, liquid, or the like, toothpaste, liquid dentifrice, dentifrice such as lubricating dentifrice, mouthwash, mouth spray, especially dentifrice or It is suitable as a mouthwash, especially a dentifrice.
Further, if necessary, in addition to the above-mentioned components, other known additives according to the dosage form can be blended as long as the effects of the present invention are not impaired. For example, abrasives, thickeners, binders, sweeteners, preservatives, various active ingredients, coloring agents, pH adjusters, fragrances, etc. can be blended, and these components are mixed with water to produce. be able to.
In the present invention, ethanol may be blended but may not be blended, and the content of ethanol may be 0 to 50%, and may be 3 to 40% of the whole composition. In the oral composition, a small amount of ethanol may be contained in a flavor or the like blended in the composition, and ethanol may not be blended in addition to such ethanol. In this case, the content of ethanol is 1%. Below, especially 0.5% or less, furthermore it is possible to be 0.3% or less.
研磨剤としては、無水ケイ酸、シリカゲル、アルミノシリケート、ジルコノシリケート、結晶性ジルコニウムシリケート等のシリカ系研磨剤、第2リン酸カルシウム無水和物又は2水和物、第3リン酸カルシウム、第4リン酸カルシウム、第8リン酸カルシウム、ピロリン酸カルシウム等のリン酸カルシウム系研磨剤、アルミナ、二酸化チタン、ポリメチルメタアクリレート、不溶性メタリン酸カルシウム、炭酸カルシウム、炭酸マグネシウム、第3リン酸マグネシウム、ゼオライト、ハイドロキシアパタイト、フルオロアパタイト、合成樹脂系研磨剤等が挙げられる。研磨剤は配合しなくても(配合量0%)よいが、研磨剤を配合する場合、その配合量は組成物全体の2〜50%、特に10〜40%がよい。 Examples of the abrasive include silica-based abrasives such as silicic anhydride, silica gel, aluminosilicate, zirconosilicate, and crystalline zirconium silicate; dibasic calcium phosphate anhydrate or dihydrate; tribasic calcium phosphate; Calcium phosphate abrasive such as calcium phosphate 8 and calcium pyrophosphate, alumina, titanium dioxide, polymethyl methacrylate, insoluble calcium metaphosphate, calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zeolite, hydroxyapatite, fluoroapatite, synthetic resin-based polishing Agents and the like. The abrasive may not be blended (blending amount 0%), but when the abrasive is blended, the blending amount is preferably 2 to 50%, particularly 10 to 40% of the whole composition.
粘稠剤としては、ソルビトール、キシリトール、エリスリトール、マルチトール、マンニトール、還元でんぷん糖化物等の糖アルコールや、グリセリン、プロピレングリコール、平均分子量(医薬部外品原料規格2006記載の平均分子量)200〜6,000のポリエチレングリコール、エチレングリコール等の多価アルコールが挙げられる。
粘稠剤の配合量は、通常、組成物全体の5〜50%である。
Examples of the thickener include sorbitol, xylitol, erythritol, maltitol, mannitol, sugar alcohols such as reduced starch saccharide, glycerin, propylene glycol, and average molecular weights (average molecular weights described in quasi-drug raw material standards 2006). And polyhydric alcohols such as polyethylene glycol and ethylene glycol.
The amount of the thickener is usually 5 to 50% of the whole composition.
粘結剤としては、ポリアクリル酸ナトリウム、キサンタンガム、カラギーナン、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル、カルボキシメチルセルロースナトリウム、ヒドロキシエチルセルロース、カーボポール、グアガム、ゼラチン、結晶セルロース、ポリビニルアルコール、ポリビニルピロリドン等の有機粘結剤、ゲル化性シリカ、ゲル化性アルミニウムシリカ、モンモリロナイト、カオリン、ベントナイト等の無機粘結剤が挙げられる。有機粘結剤の配合量は組成物全体の0.01〜5%がよく、無機粘結剤の配合量は組成物全体の0.1〜10%がよい。 Examples of the binder include organic binders such as sodium polyacrylate, xanthan gum, carrageenan, sodium alginate, propylene glycol alginate, sodium carboxymethylcellulose, hydroxyethylcellulose, carbopol, guar gum, gelatin, crystalline cellulose, polyvinyl alcohol, and polyvinylpyrrolidone. Agents, gelling silica, gelling aluminum silica, montmorillonite, kaolin, bentonite and the like. The compounding amount of the organic binder is preferably 0.01 to 5% of the whole composition, and the compounding amount of the inorganic binder is preferably 0.1 to 10% of the whole composition.
甘味剤としては、サッカリンナトリウム、アスパルテーム、ステビオサイド、ステビアエキス、ネオヘスペリジルジヒドロカルコン、ペリラルチン等が挙げられる。
防腐剤としては、ブチルパラベン、エチルパラベン等のパラオキシ安息香酸エステル、安息香酸ナトリウム等の安息香酸又はその塩が挙げられる。
Sweetening agents include saccharin sodium, aspartame, stevioside, stevia extract, neohesperidyl dihydrochalcone, perillartin and the like.
Examples of the preservative include paraoxybenzoic acid esters such as butylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.
有効成分としては、口腔用組成物に通常、配合される公知のもの、例えばフッ化物、殺菌剤、抗炎症剤、酵素、植物抽出物、歯石防止剤、歯垢防止剤等を、本発明の効果を妨げない範囲で有効量を配合できる。具体的には、フッ化ナトリウム、フッ化第1錫、フッ化ストロンチウム、モノフルオロリン酸ナトリウム等のフッ化物、正リン酸のナトリウム塩、トラネキサム酸、イプシロンアミノカプロン酸、トコフェロール酢酸エステル、α−ビサボロール、ジヒドロコレステロール、クロロヘキシジン塩類、アズレン、グリチルレチン、グリチルレチン酸、グリチルリチン酸又はその塩類や、銅クロロフィリンナトリウム、クロロフィル、グルコン酸銅等の銅化合物、グリセロホスフェート等のキレート性リン酸化合物、ヒドロキサム酸又はその誘導体、トリポリリン酸ナトリウム、メトキシエチレン、エピジヒドロコレステリン、イソプロピルメチルフェノール、塩化ベンゼトニウム、塩化セチルピリジニウム、アラントインクロルヒドロキシアルミニウム、アスコルビン酸又はその塩、アスコルビン酸リン酸エステル又はその塩、塩化リゾチーム、トリクロロカルバニリド、クエン酸亜鉛、オウバクエキスが挙げられる。 As the active ingredient, known ingredients usually blended in the oral composition, for example, fluoride, bactericide, anti-inflammatory agent, enzyme, plant extract, tartar inhibitor, plaque inhibitor, etc. of the present invention An effective amount can be blended as long as the effect is not hindered. Specifically, fluorides such as sodium fluoride, stannous fluoride, strontium fluoride and sodium monofluorophosphate, sodium salts of orthophosphoric acid, tranexamic acid, epsilon aminocaproic acid, tocopherol acetate, α-bisabolol , Dihydrocholesterol, chlorohexidine salts, azulene, glycyrrhetin, glycyrrhetinic acid, glycyrrhizic acid or salts thereof, copper compounds such as copper copper chlorophyllin, chlorophyll, copper gluconate, chelating phosphate compounds such as glycerophosphate, hydroxamic acid or derivatives thereof , Sodium tripolyphosphate, methoxyethylene, epidihydrocholesterine, isopropylmethylphenol, benzethonium chloride, cetylpyridinium chloride, allantochlorohydroxyl Chloride, ascorbic acid or a salt thereof, ascorbic acid phosphoric acid ester or its salt, lysozyme chloride, trichlorocarbanilide, zinc citrate, and a bark extract.
着色剤としては、青色1号、黄色4号、緑色3号等を通常量で配合できる。
pH調整剤としては、クエン酸、乳酸、リンゴ酸等の有機酸又はその塩や、リン酸又はその塩類、塩酸、水酸化ナトリウム、水酸化カリウム等の無機化合物が挙げられる。
As the colorant, Blue No. 1, Yellow No. 4, Green No. 3 and the like can be blended in usual amounts.
Examples of the pH adjuster include organic acids such as citric acid, lactic acid, and malic acid or salts thereof, phosphoric acids and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, and potassium hydroxide.
香料としては、例えば、アニス油、ウィンターグリーン油、タイム油、セージ油、カルダモン油、コリアンダー油、ラベンダー油、カモミル油、キャラウェイ油、マジョラム油、レモングラス油、オリガナム油、パインニードル油、ネロリ油、ローズ油、ジャスミン油、イリスコンクリート、アブソリュートローズ、オレンジフラワー等の天然香料、及びこれら天然香料の加工処理(前溜部カット、後溜部カット、分留、液液抽出、エッセンス化、粉末香料化等)した香料や、メントール、カルボン、アネトール、サリチル酸メチル、チモール、リナロール、リナリールアセテート、メントン、メンチルアセテート、ピネン、オクチルアルデヒド、プレゴン、カルビルアセテート、アニスアルデヒド、エチルアセテート、エチルブチレート、アリルシクロヘキサンプロピオネート、メチルアンスラニレート、エチルメチルフェニルグリシデート、バニリン、ウンデカラクトン、ヘキサナール、プロピルアルコール、ブタノール、イソアミルアルコール、ヘキセノール、ジメチルサルファイド、シクロテン、トリメチルピラジン、エチルラクテート、メチルラクテート、エチルチオアセテート等の単品香料、更に、ストロベリーフレーバー、アップルフレーバー、バナナフレーバー、パイナップルフレーバー、グレープフレーバー、マンゴーフレーバー、バターフレーバー、ミルクフレーバー、フルーツミックスフレーバー、トロピカルフルーツフレーバー等の調合香料といった口腔用組成物に用いられる公知の香料素材を使用することができる。これらの香料素材の配合量は、特に限定されないが、組成物中に0.000001〜1%使用するのが好ましい。また、上記香料素材を使用した賦香用香料は、組成物中に0.1〜2%使用するのが好ましい。
なお、本発明では、メントールを配合する場合、その含有量は組成物全体の0.1〜5%、特に0.3〜2%が好ましく、あるいはメントールを配合しなくても(含有量0%)よい。
Examples of the fragrance include anise oil, winter green oil, thyme oil, sage oil, cardamom oil, coriander oil, lavender oil, chamomile oil, caraway oil, marjoram oil, lemongrass oil, origanum oil, pine needle oil, and neroli. Natural fragrances such as oil, rose oil, jasmine oil, iris concrete, absolute rose, orange flower, etc., and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractionation, liquid-liquid extraction, essence, powder Fragrance, menthol, carvone, anethole, methyl salicylate, thymol, linalool, linalool acetate, menthone, menthyl acetate, pinene, octyl aldehyde, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate , Rylcyclohexanepropionate, methylanthranilate, ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, trimethyl pyrazine, ethyl lactate, methyl lactate, ethyl Oral compositions such as single flavors such as thioacetate, and also flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor. Known perfume materials used can be used. The amount of these fragrance materials is not particularly limited, but is preferably used in the composition in an amount of 0.000001 to 1%. In addition, it is preferable to use 0.1 to 2% of the fragrance for flavoring using the above fragrance material in the composition.
In the present invention, when menthol is blended, the content is preferably 0.1 to 5%, particularly 0.3 to 2% of the whole composition, or even if menthol is not blended (content 0%). ) Good.
以下、実施例及び比較例、更には処方例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、下記の例において%は特に断らない限りいずれも質量%を示す。 Hereinafter, the present invention will be described in detail with reference to Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.
[実施例、比較例]
表1に示す組成に従い、表2〜7に示す歯磨剤組成物(練歯磨)を常法により調製した。得られた歯磨剤組成物を後述の方法で評価し、結果を表に併記した。
なお、表中の(A)成分の配合量を示す数値は純分量である。
[Examples and Comparative Examples]
According to the composition shown in Table 1, dentifrice compositions (toothpaste) shown in Tables 2 to 7 were prepared by a conventional method. The obtained dentifrice composition was evaluated by the method described below, and the results are shown in the table.
In addition, the numerical value which shows the compounding quantity of (A) component in a table | surface is a pure amount.
(*)香料の組成は下記の通りである。
アネトール 10
メントール 50
エタノール 40
合計 100%
(*) The composition of the fragrance is as follows.
Anethole 10
Menthol 50
Ethanol 40
100% in total
歯磨剤組成物の調製に使用した原料を下記に示す。
(A)シチュアンペッパー抽出物(商品名;SICHUAN PEPPER
ABSOLUTE CO2 EXTRACT、シャラボ(株)製、AI;100%)
(B)シネオール((株)永廣堂本店製)
(C)(C1)シトラール(長谷川香料(株)製
(C)(C2)リモネン(高砂香料工業(株)製)
(D)N−エチル−p−メンタン−3−カルボキサミド(商品名;WS−3、ジボダン
ジャパン(株)製)
(D)N−(4−シアノメチルフェニル)−2−イソプロピル−5−メチルシクロヘキサ
ンカルボキサミド(商品名;Evercool G−180、ジボダンジャパン
(株)製)
なお、(E)成分のポリオキシエチレン(20)硬化ヒマシ油、ポリオキシエチレン(60)硬化ヒマシ油、ラウロイルメチルタウリンナトリウム、更には上記以外の成分は、いずれも外原規(医薬部外品原料規格)規格品を用い、精製水は粧原基(化粧品原料基準)規格品を用いた。
The raw materials used for preparing the dentifrice composition are shown below.
(A) Situan pepper extract (trade name: SICHUAN PEPPER)
(ABSOLUTE CO2 EXTRACT, manufactured by Shalabo Inc., AI; 100%)
(B) Cineol (manufactured by Eikodo Head Office)
(C) (C1) Citral (Hasegawa Perfume Co., Ltd. (C) (C2) Limonene (Takasago Perfumery Co., Ltd.)
(D) N-ethyl-p-menthan-3-carboxamide (trade name; WS-3, manufactured by Dibodan Japan KK)
(D) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (trade name; Evercool G-180, manufactured by Dibodan Japan Co., Ltd.)
The component (E), polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, sodium lauroylmethyltaurine, and components other than those described above, were all used in the outer standards (quasi-drugs). Raw material standard) standard product was used, and purified water used was a cosmetic primordia (cosmetic raw material standard) standard product.
評価方法
10名の被験者により評価した。1gの歯磨剤組成物を歯刷子(デンターシステマ ライオンハブラシ、レギュラー、ライオン(株)製)にとり、3分間のブラッシングを行い、口腔内で使用中の洗浄実感、使用後の洗浄実感と、嫌味のなさについて、それぞれ下記の評点基準で、絶対評価での官能試験を行った。
10名の平均値をそれぞれ求め、下記の評価基準で評価した。
Evaluation method Evaluation was performed by 10 subjects. 1 g of the dentifrice composition was applied to a toothbrush (Denter Systema Lion Toothbrush, Regular, manufactured by Lion Co., Ltd.) and brushed for 3 minutes to give a feeling of washing during use in the oral cavity, a feeling of washing after use, and an unpleasant taste. With respect to the lack, a sensory test was performed by absolute evaluation according to the following evaluation criteria.
The average value of 10 persons was determined and evaluated according to the following evaluation criteria.
ここで、使用中の洗浄実感とは、口に含んだとき口腔内で泡がはじけるような感覚(発泡感)によって口腔内が洗浄されたように感じられる実感をいう。
また、使用後の洗浄実感とは、口を濯いだ後も口腔内で上記感覚(発泡感)によって口腔内が洗浄されたように感じられる実感があることをいう。
Here, the feeling of washing during use refers to the feeling of feeling that the inside of the mouth is washed by a feeling (foaming feeling) that bubbles are blown out of the mouth when contained in the mouth.
Further, the feeling of washing after use means that there is a feeling that the inside of the mouth is washed by the above-mentioned sensation (foaming feeling) even after rinsing the mouth.
(i)使用中の洗浄実感
評点基準
4点:口腔内の洗浄感を非常に感じる
3点:口腔内の洗浄感を感じる
2点:口腔内の洗浄感をやや感じる
1点:口腔内の洗浄感を全く感じない
評価基準
使用中の洗浄実感の平均点
◎:3.5点以上4.0点以下
○:3.0点以上3.5点未満
△:2.0点以上3.0点未満
×:1.0点以上2.0点未満
(I) Actual feeling of washing during use Evaluation criteria 4 points: Feel the feeling of washing in the oral cavity 3 points: Feel the feeling of washing in the oral cavity 2 points: Feel the feeling of washing in the oral cavity 1 point: Washing of the oral cavity No feeling at all Evaluation criteria Average point of actual cleaning feeling during use ◎: 3.5 or more and 4.0 or less :: 3.0 or more and less than 3.5 Δ: 2.0 or more and 3.0 points Less than ×: 1.0 or more and less than 2.0 points
(ii)使用後の洗浄実感
評点基準
4点:口腔内の洗浄感を非常に感じる
3点:口腔内の洗浄感を感じる
2点:口腔内の洗浄感をやや感じる
1点:口腔内の洗浄感を全く感じない
評価基準
使用後の洗浄実感の平均点
◎:3.5点以上4.0点以下
○:3.0点以上3.5点未満
△:2.0点以上3.0点未満
×:1.0点以上2.0点未満
(Ii) Feeling of washing after use Evaluation criteria 4 points: Feel the feeling of washing in the oral cavity 3 points: Feel the feeling of washing in the oral cavity 2 points: Feel slightly the feeling of washing in the oral cavity 1 point: Washing of the oral cavity No feeling is felt Evaluation criteria Average point of actual cleaning feeling after use ◎: 3.5 or more and 4.0 or less :: 3.0 or more and less than 3.5 Δ: 2.0 or more and 3.0 points Less than ×: 1.0 or more and less than 2.0 points
(iii)嫌味のなさ
評点基準
4点:嫌味をほとんど感じない
3点:嫌味をやや感じるが問題ない
2点:嫌味を感じる
1点:嫌味を非常に感じる
評価基準
嫌味のなさの平均点
◎:3.5点以上4.0点以下
○:3.0点以上3.5点未満
△:2.0点以上3.0点未満
×:1.0点以上2.0点未満
(Iii) Lack of hate Rating criteria 4 points: Almost no hate 3 points: Feel a little hate but no problem 2 points: Feel the hate 1 point: Feel the hate very much Evaluation criteria Average score of no hate ◎: 3.5 or more and 4.0 or less :: 3.0 or more and less than 3.5 points Δ: 2.0 or more and less than 3.0 points ×: 1.0 or more and less than 2.0 points
表2〜6の結果からわかるように、本発明の歯磨剤組成物(実施例)は、使用中及び使用後の洗浄実感が共に優れ、また、嫌味が抑制されて味も良かった。これに対して、表7の結果からわかるように、(A)、(B)及び(C)成分のうちのいずれかを欠く歯磨剤組成物(比較例)は、使用中及び使用後の洗浄実感が劣っていた。 As can be seen from the results of Tables 2 to 6, the dentifrice compositions (Examples) of the present invention were excellent in both the feeling of washing during use and after use, and also had a good taste with suppressed unpleasantness. In contrast, as can be seen from the results in Table 7, the dentifrice compositions lacking any of the components (A), (B) and (C) (comparative examples) were washed during and after use. The feeling was inferior.
下記に処方例を示す。処方例の口腔用製剤を、上記と同様の原料を使用して常法によって調製し、それぞれを通常の方法で使用して上記と同様に評価したところ、使用中及び使用後の洗浄実感に優れ、嫌味が抑えられ味も良好であった。 An example of the formulation is shown below. The oral preparations of the formulation examples were prepared by the usual method using the same raw materials as described above, and each was evaluated in the same manner as above using the usual method. In addition, the taste was good, with the unpleasant taste suppressed.
[処方例1](洗口剤)
(A)シチュアンペッパー抽出物 0.01
(B)シネオール 0.1
(C)(C1)シトラール 0.01
(E)ポリオキシエチレン(60)硬化ヒマシ油 0.3
エタノール 5
プロピレングリコール 2
グリセリン 2
キシリトール 3
クエン酸ナトリウム 0.25
香料 0.1
精製水 残部
合計 100.0%
(B)/(A)=10、(C1)/(A)=1
[Formulation Example 1] (Mouthwash)
(A) situ pepper extract 0.01
(B) Cineol 0.1
(C) (C1) Citral 0.01
(E) Polyoxyethylene (60) hydrogenated castor oil 0.3
Ethanol 5
Propylene glycol 2
Glycerin 2
Xylitol 3
Sodium citrate 0.25
Fragrance 0.1
Purified water balance
100.0% in total
(B) / (A) = 10, (C1) / (A) = 1
[処方例2](洗口剤)
(A)シチュアンペッパー抽出物 0.005
(B)シネオール 0.02
(C)(C2)リモネン 0.05
(E)ポリオキシエチレン(60)硬化ヒマシ油 0.4
(E)ポリオキシエチレン(15)セチルエーテル 0.2
(E)ラウロイルメチルタウリンナトリウム 0.2
安息香酸ナトリウム 0.3
プロピレングリコール 3
グリセリン 2
キシリトール 4
クエン酸ナトリウム 0.25
パラオキシ安息香酸メチル 0.05
香料 0.05
精製水 残部
合計 100.0%
(B)/(A)=4、(C2)/(A)=10
[Formulation Example 2] (Mouthwash)
(A) situ pepper extract 0.005
(B) Cineol 0.02
(C) (C2) limonene 0.05
(E) Polyoxyethylene (60) hydrogenated castor oil 0.4
(E) polyoxyethylene (15) cetyl ether 0.2
(E) sodium lauroylmethyltaurine 0.2
Sodium benzoate 0.3
Propylene glycol 3
Glycerin 2
Xylitol 4
Sodium citrate 0.25
Methyl paraoxybenzoate 0.05
Fragrance 0.05
Purified water balance
100.0% in total
(B) / (A) = 4, (C2) / (A) = 10
[処方例3](マウススプレー剤)
(A)シチュアンペッパー抽出物 0.005
(B)シネオール 0.05
(C)(C1)シトラール 0.01
(C)(C2)リモネン 0.25
(E)ポリオキシエチレン(60)硬化ヒマシ油 3
エタノール 35
グリセリン 10
キシリトール 2
サッカリンナトリウム 0.3
クエン酸ナトリウム 0.15
香料 0.5
精製水 残部
合計 100.0%
(B)/(A)=10、(C1)/(A)=2、(C2)/(A)=50
[Formulation Example 3] (mouse spray)
(A) situ pepper extract 0.005
(B) Cineol 0.05
(C) (C1) Citral 0.01
(C) (C2) limonene 0.25
(E) Polyoxyethylene (60) hydrogenated castor oil 3
Ethanol 35
Glycerin 10
Xylitol 2
Saccharin sodium 0.3
Sodium citrate 0.15
Spice 0.5
Purified water balance
100.0% in total
(B) / (A) = 10, (C1) / (A) = 2, (C2) / (A) = 50
[処方例4](練歯磨剤)
(A)シチュアンペッパー抽出物 0.03
(B)シネオール 0.5
(C)(C1)シトラール 0.01
(C)(C2)リモネン 0.05
(D)N−エチル−p−メンタン−3−カルボキサミド 0.05
(E)ポリオキシエチレン(20)硬化ヒマシ油 1.5
(E)テトラデセンスルホン酸ナトリウム 0.3
(E)ヤシ油脂肪酸アミドプロピルベタイン 0.5
(E)ラウロイルサルコシンナトリウム 0.1
ソルビトール 35
プロピレングリコール 4
ポリエチレングリコール4000 0.4
研磨性シリカ 15
増粘性シリカ 3
キサンタンガム 0.8
カラギーナン 0.8
ポリアクリル酸ナトリウム 0.5
パラオキシ安息香酸メチル 0.18
酸化チタン 0.5
クエン酸 0.1
水酸化ナトリウム 0.24
フッ化ナトリウム 0.3
サッカリンナトリウム 0.18
香料 0.5
精製水 残部
合計 100.0%
[Formulation Example 4] (Toothpaste)
(A) situ pepper extract 0.03
(B) Cineol 0.5
(C) (C1) Citral 0.01
(C) (C2) limonene 0.05
(D) N-ethyl-p-menthan-3-carboxamide 0.05
(E) Polyoxyethylene (20) hydrogenated castor oil 1.5
(E) Sodium tetradecene sulfonate 0.3
(E) Coconut oil fatty acid amidopropyl betaine 0.5
(E) Lauroyl sarcosine sodium 0.1
Sorbitol 35
Propylene glycol 4
Polyethylene glycol 4000 0.4
Abrasive silica 15
Thickening silica 3
Xanthan gum 0.8
Carrageenan 0.8
Sodium polyacrylate 0.5
Methyl paraoxybenzoate 0.18
Titanium oxide 0.5
Citric acid 0.1
Sodium hydroxide 0.24
Sodium fluoride 0.3
Saccharin sodium 0.18
Fragrance 0.5
Purified water balance
100.0% in total
[処方例5](練歯磨剤)
(A)シチュアンペッパー抽出物 0.03
(B)シネオール 0.5
(C)(C1)シトラール 0.01
(C)(C2)リモネン 0.05
(D)N−エチル−p−メンタン−3−カルボキサミド 0.05
(E)ポリオキシエチレン(20)硬化ヒマシ油 0.5
(E)ポリオキシエチレン(5)ラウリルエーテル 0.5
(E)ラウリル硫酸ナトリウム 1.2
ソルビトール 35
プロピレングリコール 4
ポリエチレングリコール4000 0.4
研磨性シリカ 10
増粘性シリカ 3
キサンタンガム 0.3
アルギン酸ナトリウム 0.8
カラギーナン 1
パラオキシ安息香酸メチル 0.18
酸化チタン 0.5
クエン酸 0.1
水酸化ナトリウム 0.24
モノフルオロリン酸ナトリウム 1.1
イソプロピルメチルフェノール 0.1
サッカリンナトリウム 0.18
香料 0.5
精製水 残部
合計 100.0%
[Prescription Example 5] (Toothpaste)
(A) situ pepper extract 0.03
(B) Cineol 0.5
(C) (C1) Citral 0.01
(C) (C2) limonene 0.05
(D) N-ethyl-p-menthan-3-carboxamide 0.05
(E) Polyoxyethylene (20) hydrogenated castor oil 0.5
(E) polyoxyethylene (5) lauryl ether 0.5
(E) Sodium lauryl sulfate 1.2
Sorbitol 35
Propylene glycol 4
Polyethylene glycol 4000 0.4
Abrasive silica 10
Thickening silica 3
Xanthan gum 0.3
Sodium alginate 0.8
Carrageenan 1
Methyl paraoxybenzoate 0.18
Titanium oxide 0.5
Citric acid 0.1
Sodium hydroxide 0.24
Sodium monofluorophosphate 1.1
Isopropyl methyl phenol 0.1
Saccharin sodium 0.18
Spice 0.5
Purified water balance
100.0% in total
Claims (10)
(B)シネオール
及び
(C)(C1)シトラール及び(C2)リモネンから選ばれる1種以上
を含有する口腔用組成物。 (A) situ pepper extract,
An oral composition comprising (B) cineol and (C) one or more selected from (C1) citral and (C2) limonene.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111544353A (en) * | 2020-05-21 | 2020-08-18 | 天津芸熙生物技术有限公司 | Antibacterial oral spray and preparation method thereof |
WO2022064598A1 (en) * | 2020-09-24 | 2022-03-31 | ライオン株式会社 | Polyhydric alcohol-based dentifrice composition |
WO2023063269A1 (en) * | 2021-10-11 | 2023-04-20 | ライオン株式会社 | Nonaqueous composition for oral cavity |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727407A (en) * | 2012-03-31 | 2012-10-17 | 重庆和信农业发展有限公司 | Health-care toothpaste containing Chinese prickly ash extracts |
CN103947994A (en) * | 2014-04-18 | 2014-07-30 | 大姚家和天然食品开发有限责任公司 | Wild pepper extract and preparation method thereof |
JP2017514881A (en) * | 2014-05-14 | 2017-06-08 | ザ プロクター アンド ギャンブル カンパニー | Oral care composition with improved stability |
-
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- 2019-06-27 JP JP2019119632A patent/JP7310357B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727407A (en) * | 2012-03-31 | 2012-10-17 | 重庆和信农业发展有限公司 | Health-care toothpaste containing Chinese prickly ash extracts |
CN103947994A (en) * | 2014-04-18 | 2014-07-30 | 大姚家和天然食品开发有限责任公司 | Wild pepper extract and preparation method thereof |
JP2017514881A (en) * | 2014-05-14 | 2017-06-08 | ザ プロクター アンド ギャンブル カンパニー | Oral care composition with improved stability |
Non-Patent Citations (1)
Title |
---|
WHITENING TOOTHPASTE, TAIYEN CORP., 2017年4月, MINTEL GNPD [ONLINE], JPN6023009227, ISSN: 0005011595 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111544353A (en) * | 2020-05-21 | 2020-08-18 | 天津芸熙生物技术有限公司 | Antibacterial oral spray and preparation method thereof |
WO2022064598A1 (en) * | 2020-09-24 | 2022-03-31 | ライオン株式会社 | Polyhydric alcohol-based dentifrice composition |
WO2023063269A1 (en) * | 2021-10-11 | 2023-04-20 | ライオン株式会社 | Nonaqueous composition for oral cavity |
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