WO2016121650A1

WO2016121650A1 - Dentifrice composition

Info

Publication number: WO2016121650A1
Application number: PCT/JP2016/051874
Authority: WO
Inventors: 深澤　哲
Original assignee: ライオン株式会社
Priority date: 2015-01-26
Filing date: 2016-01-22
Publication date: 2016-08-04
Also published as: KR20170104996A; CN107205900A; JP2016138047A

Abstract

Provided is a dentifrice composition that exhibits an excellent effect of sealing dentinal fine tubules, effectively suppresses a lowering of pH, shows a controlled lowering of pH with the passage of time, gives a suppressed metallic taste and a good feeling in use and is appropriately usable for inhibiting dentinal hyperesthesia, said dentifrice composition comprising: (A) 0.01-5 mass% of aluminum lactate; (B) 0.01-5 mass% of a fused phosphate; and (C) 0.1-3 mass% of an α-olein sulfonic acid. Also provided is a method for suppressing a lowering of pH and expression of a metallic taste in the aforesaid dentifrice composition, said method comprising blending a dentifrice composition containing 0.01-5 mass% of component (A) with 0.01-5 mass% of component (B) and 0.1-3 mass% of component (C).

Description

Dentifrice composition

The present invention has a high dentinal tubule sealing effect and an excellent pH lowering suppression effect, suppresses the pH drop over time, has a good metallic feel and a good feeling of use, and contains aluminum lactate suitable for suppressing hypersensitivity It relates to a dentifrice composition.

Aluminum lactate has dentinal tubule stenosis occlusion and is effective in preventing or treating dentin hypersensitivity, but when aluminum lactate is added to the oral composition, the pH decreases over time, and it tends to become acidic. There have been problems of decalcification of the teeth and exfoliation of the oral mucosa and poor stability, and the appearance of a metallic taste peculiar to aluminum has also been a problem.

In order to deal with such problems, Patent Document 1 (Japanese Patent Laid-Open No. 10-231237) describes that by adding a sugar alcohol to a liquid oral composition containing aluminum lactate, white turbidity and precipitation are prevented and stability is improved. An improved technique has been proposed, and Patent Document 2 (Japanese Patent Laid-Open No. 2013-119520) discloses an anionic surfactant, a specific water-soluble polymer substance, a dentifrice composition containing potassium nitrate and / or aluminum lactate, There have been proposed technologies that ensure sufficient foaming and improve storage stability (liquid separation stability) by blending propylene glycol alginate, but there is no mention of pH fluctuation over time.

On the other hand, it is known that a condensed phosphate can be blended with an aluminum lactate in an oral composition, and Patent Document 3 (Japanese Patent Laid-Open No. 7-165550) discloses that it is effective in preventing and treating dentinal hypersensitivity. As an oral composition, an oral band (Example 7) containing aluminum lactate and sodium pyrophosphate is described. Patent Document 4 (Japanese Patent Application Laid-Open No. 2002-302429) proposes a non-aqueous oral composition in which aluminum lactate is blended as an acidic component together with a non-aqueous oral composition base material and baking soda to improve bitterness and itchiness. Furthermore, sodium pyrophosphate and sodium polyphosphate are described as examples of the calculus deposition preventing component that can be further blended. Patent Document 5 (Japanese Patent Application Laid-Open No. 2004-26816) discloses that aluminum lactate, sodium pyrophosphate, sodium polyphosphate, and the like can be blended in a solid dosage form oral composition.

Japanese Patent Laid-Open No. 10-231237 JP 2013-119520 A JP 7-165550 A JP 2002-302429 A JP 2004-26816 A

However, the suppression of the pH drop of the oral composition containing aluminum lactate is not sufficient and there is room for improvement, and the development of a technique for more effectively suppressing the pH drop has been desired.

The present invention has been made in view of the above circumstances. Aluminum lactate exhibits a high dentinal tubule sealing effect and is excellent in pH lowering suppression effect, suppressed pH decrease over time, and suppressed metallic taste and good usability. It aims at providing the dentifrice composition containing.

As a result of intensive studies to achieve the above object, the present inventor has found (A) a dentifrice composition containing 0.01 to 5% by mass of aluminum lactate and (B) 0.01 to 5% of condensed phosphate. By blending 5% by mass and 0.1 to 3% by mass of (C) α-olefin sulfonate, it exhibits a high dentinal tubule-sealing effect and is excellent in pH reduction inhibiting effect. In addition, the metal taste was suppressed, the usability was improved, and it was found that it can be suitably used to suppress hypersensitivity, and the present invention has been made.

That is, as shown in a comparative example described later, a dentifrice composition containing aluminum lactate does not contain pyrophosphate and α-olefin sulfonate, and does not contain anionic surfactant sodium lauryl sulfate. However, the pH decreases over time, the pH fluctuates, the metal taste appears and the taste is poor (Comparative Example 7), and either pyrophosphate and α-olefin sulfonate are blended. If the amount is inadequate, the pH will drop, or a metallic taste or oily feeling will appear and the feeling of use will worsen (Comparative Examples 3 to 6). On the other hand, as shown in the examples described later, when (A) aluminum lactate and (B) condensed phosphate and (C) α-olefin sulfonate are combined in an appropriate amount and blended into the dentifrice composition, The combination of the components (B) and (C) acts specifically, and the dentinal tubule sealing effect of aluminum lactate is excellent, and the pH change is less than 1.0 even when stored at 50 ° C. for 1 month. It has a suppressive effect, pH can be stabilized over time, and it can be prevented from being acidic, and it can also suppress the metallic taste, prevent the appearance of oiliness, and give a good feeling of good taste. .
In this case, if the amount of the component (B) is too large, the metal taste derived from the component (A) is more strongly expressed, and if the amount of the component (C) is too large, a feeling of oil is strongly generated. By appropriately combining the components (B) and (C), all of these problems can be solved and the above-mentioned special effects can be imparted.

Accordingly, the present invention provides the following dentifrice composition and a method for suppressing the decrease in pH and expression of metallic taste in the dentifrice composition.
[1]
(A) 0.01-5% by mass of aluminum lactate, (B) 0.01-5% by mass of condensed phosphate, and (C) 0.1-3% by mass of α-olefin sulfonate. A dentifrice composition characterized by comprising
[2]
The dentifrice composition according to [1], wherein the condensed phosphate of component (B) is pyrophosphate or tripolyphosphate.
[3]
(C) The dentifrice composition according to [1] or [2], wherein the α-olefin sulfonate is an α-olefin sulfonate having 14 to 16 carbon atoms.
[4]
The toothbrush according to any one of [1] to [3], wherein (B) / (A) is from 0.005 to 50 in terms of mass ratio, and (C) / (A) is in the range of from 0.05 to 100 Composition.
[5]
The dentifrice composition according to any one of [1] to [4], further comprising (D) 0.1 to 7% by mass of potassium nitrate.
[6]
The dentifrice composition according to any one of [1] to [5], wherein the pH at 25 ° C is 5 or more.
[7]
The dentifrice composition according to any one of [1] to [6], which is prepared as a toothpaste.
[8]
(A) A dentifrice composition containing 0.01-5% by mass of aluminum lactate, (B) 0.01-5% by mass of condensed phosphate, and (C) 0.1% of α-olefin sulfonate. A method for suppressing the decrease in pH and the appearance of metallic taste in the dentifrice composition by blending ˜3 mass%.
[9]
(B) / (A) has a mass ratio of 0.005 to 50, and (C) / (A) has a mass ratio of 0.05 to 100, and the pH reduction in the dentifrice composition according to [8] A method for suppressing the expression of metallic taste.
[10]
(D) A method for suppressing a decrease in pH and expression of metallic taste in the dentifrice composition according to [8] or [9], wherein 0.1 to 7% by mass of potassium nitrate is blended.
[11]
The method for suppressing a decrease in pH and expression of metallic taste in a dentifrice composition according to any one of [8] to [10], wherein the dentifrice composition has a pH of 5 or more at 25 ° C.
[12]
A method for suppressing a decrease in pH and expression of a metallic taste in the dentifrice composition according to any one of [8] to [11] prepared in a toothpaste.

According to the present invention, there is a high dentinal tubule sealing effect and an excellent pH lowering suppressing effect, the pH lowering is suppressed over time, the metallic taste is suppressed, the oily feeling is also suppressed, and a good feeling of use is given. A dentifrice composition containing aluminum lactate suitable for suppression can be provided.

Hereinafter, the present invention will be described in further detail. The dentifrice composition of the present invention contains (A) aluminum lactate, (B) condensed phosphate, and (C) α-olefin sulfonate.

(A) Aluminum lactate is a reaction product of lactic acid and metallic aluminum, is represented by the chemical formula C ₉ H ₁₅ AlO ₉ , and is a white, odorless powder. As an effect on the teeth, a dentinal tubule sealing effect that narrows or occludes the dentinal tubule is known, and has an effect of reducing dentinal hypersensitivity caused by exposure of the dentinal tubule. Commercially available aluminum lactate can be used.
The blending amount of the component (A) aluminum lactate is 0.01 to 5% (mass%, hereinafter the same) of the whole composition, preferably 0.1 to 3%, more preferably 1 to 2%. It is. When 0.01% or more is blended, a sufficient dentinal tubule sealing effect can be imparted. If too much is added, it is preferable to sufficiently suppress the pH drop and improve the feeling of use. If it exceeds 5%, the tendency to drop the pH becomes very strong, and the metallic taste is strongly expressed. .

In the present invention, the combination of (B) condensed phosphate and (C) α-olefin sulfonate gives a high dentinal tubule sealing effect and an excellent pH reduction inhibiting effect, and also provides a feeling of use. Improve. If the component (B) is absent, the pH drop cannot be suppressed, and if the component (C) is absent, the metallic taste is not suppressed and the usability is poor.

(B) As the condensed phosphate, a linear or cyclic condensed phosphate represented by the following general formula (1) or (2) may be used.
M _{n + 2} P _n O _{3n + 1} (1)
(MPO ₃ ) _m (2)
(In the formula, M represents Na or K, n is an integer of 2 or more, and m is an integer of 3 or more.)
The linear polyphosphate represented by the general formula (1) includes n = 2 sodium pyrophosphate and potassium pyrophosphate, n = 3 sodium tripolyphosphate and potassium tripolyphosphate, and n = 4 tetrapolyphosphoric acid. Examples include sodium and potassium tetrapolyphosphate, sodium metaphosphate having high polymerization degree, and potassium metaphosphate.
Examples of the cyclic polyphosphate represented by the general formula (2) include m = 3 sodium trimetaphosphate and potassium trimetaphosphate, m = 4 sodium tetrametaphosphate and potassium tetrametaphosphate, and m = 6 sodium hexametaphosphate. And potassium hexametaphosphate.
These condensed phosphates can be used singly or in combination of two or more, and among them, linear water-soluble condensed phosphates are preferable, and pyrophosphates, tripolyphosphates, especially pyrophosphoric acid are particularly preferable. A salt is more preferable, and a sodium salt is still more preferable.
Specifically, commercially available products can be used, for example, sodium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Tohoku Chemical Co., Ltd.), potassium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Toagosei Co., Ltd.) ), Sodium tripolyphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Central Glass Co., Ltd., Nippon Builder Co., Ltd.) and the like can be used.

The blending amount of the (B) component condensed phosphate is 0.01 to 5%, preferably 0.1 to 1%, more preferably 0.3 to 0.5% of the entire composition. If the blending amount is 0.01% or more, a satisfactory pH reduction suppressing effect can be imparted. If too much is added, it is suitable for improving the feeling of use, and if it exceeds 5%, the metallic taste is strongly developed and the feeling of use is lowered.

(C) As the α-olefin sulfonate, an alkali metal salt such as a sodium salt or potassium salt of an α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and an α-olefin sulfonic acid having 14 carbon atoms can be used. Salts, particularly sodium salts (generic name; sodium tetradecenesulfonate) are preferred.
As these α-olefin sulfonates, commercially available products can be used. Specifically, sodium tetradecene sulfonate (α-olefin (C14) sodium sulfonate, manufactured by Lion Specialty Chemicals Co., Ltd., “K Lipolane PJ-400CJ”) and the like can be used.
The α-olefin sulfonate may contain a hydroxyalkyl sulfonate as a by-product, and the ratio is not particularly limited, but is usually 20% or less. Acid salts can be used in the present invention.

The blending amount of the component (C) α-olefin sulfonate is 0.1 to 3% of the total composition, preferably 0.5 to 2%, more preferably 0.7 to 1.5%. is there. A feeling in use can be improved as it exists in the range of the said compounding quantity. If the blending amount is less than 0.1%, the metal taste cannot be suppressed, and if it exceeds 3%, an oily feeling is strongly expressed, the taste is poor and the feeling of use is inferior.

In addition, even if it is an anionic surfactant or an alkyl sulfate such as sodium lauryl sulfate is combined with (B) the condensed phosphate, (A) the decrease in feeling of use due to aluminum lactate is not improved, The object of the present invention is not achieved.

In the present invention, when the components (B) and (C) are combined in an appropriate ratio with the component (A), the effect of suppressing the decrease in pH is further improved and the feeling in use can be further improved.
In this case, (B) / (A) indicating the blending amount of the component (B) with respect to the blending amount of the component (A) can be 0.005 to 50 as the mass ratio, preferably 0.005 to 5 More preferably, it is 0.1-3. Further, (C) / (A) indicating the blending amount of the component (C) with respect to the blending amount of the component (A) can be 0.05 to 100 as a mass ratio, preferably 0.05 to 3, More preferably, it is 0.3 to 1.
The effect of this invention is more excellent in (B) / (A) and / or (C) / (A) being in the range of the said ratio.

Furthermore, in this invention, (D) potassium nitrate can be mix | blended. Potassium nitrate relieves pain caused by hypersensitivity and is effective as a hypersensitivity inhibitor.
The blending amount of component (D) potassium nitrate is preferably 0.1 to 7%, more preferably 0.5 to 5% of the total composition. Addition within this range is suitable for enhancing the effect of suppressing hypersensitivity. Moreover, it is suitable also in the suppression effect of pH fall of this invention, and suppression of expression of a metallic taste.

The dentifrice composition of the present invention preferably has a pH at 25 ° C. of 5 or more, particularly 5 to 10, more preferably 6 to 8, and is preferably adjusted to such a pH. When the pH is 5 or more, a sufficient dentinal tubule sealing effect is exhibited, and it is suitable for use.
In addition, when adjusting pH, you may add a pH adjuster, for example, hydroxide of alkali metals, such as sodium hydroxide, hydrogencarbonate, carbonate, etc. can also be added.

The dentifrice composition of the present invention is suitably prepared as a toothpaste, such as a toothpaste, a liquid toothpaste, and a toothpaste. Moreover, in addition to the said component, another well-known component can be mix | blended as needed in the range which does not prevent the effect of this invention. For example, in a toothpaste, an abrasive, a binder, a thickener, a surfactant, and a sweetener, a colorant, a preservative, a fragrance, an active ingredient, and the like can be blended as necessary. In addition, water can be mix | blended as a liquid medium and it can prepare by a normal method.

Examples of the abrasive include silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, calcium phosphate-based compounds, calcium carbonate, aluminum hydroxide, and synthetic resin-based abrasives. The blending amount of the abrasive is usually 10 to 50% for toothpaste and 0 to 30% for liquid toothpaste.

Examples of the binder include gums such as carrageenan and xanthan gum, organic binders such as cellulose derivatives such as carboxymethylcellulose sodium, and inorganic binders such as gelling silica and gelling aluminum silica. The amount of the binder is usually 0.1 to 10%, preferably 0.1 to 5% for toothpaste and 0 to 5% for liquid toothpaste.

Examples of the thickener include sugar alcohols such as sorbit, xylit, and propylene glycol, and polyhydric alcohols. The blending amount of the thickener is usually 5 to 50%, particularly preferably 20 to 45%.

As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate. Nonionic surfactants include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 5 to 60, sugar fatty acid esters, sugar alcohol fatty acid esters, polyglycerin fatty acid esters, polyoxy Examples include ethylene higher alcohol ethers.
Examples of cationic surfactants include alkylammonium types, and examples of amphoteric surfactants include betaine types and imidazoline types.
The blending amount of the surfactant can be adjusted according to the form, purpose of use, and the like, for example, 0 to 10% for toothpaste and 0 to 5% for liquid toothpaste.

Examples of sweeteners include sodium saccharin and the like, and examples of colorants include blue No. 1, yellow No. 4, and titanium dioxide. Examples of the preservative include paraoxybenzoic acid esters such as methyl paraben and ethyl paraben, benzoic acid or a salt thereof.

Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumed, menthol, moss Bonn, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl thiol For oral compositions such as single flavors such as acetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. Although it can be used combining the well-known fragrance | flavor raw material used, it is not limited to the fragrance | flavor of an Example description.
Further, the blending amount is not particularly limited, but the above fragrance material is preferably used at 0.000001 to 1% in the preparation composition. The flavoring fragrance using the fragrance material is preferably used in an amount of 0.1 to 2% in the preparation composition.

As the active ingredient, known ingredients that are usually blended in dentifrice compositions, such as bactericides, anti-inflammatory agents, enzymes, fluorides, plant extracts, tartar inhibitors, dental plaque inhibitors, and the like can be blended. For example, nonionic fungicides such as isopropylmethylphenol, cationic fungicides, tranexamic acid, epsilon aminocaproic acid, anti-inflammatory agents such as allantoin, enzymes such as dextranase, sodium fluoride, sodium monofluorophosphate, etc. Fluoride etc. are mentioned. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

Hereinafter, although an Example, a comparative example, and a formulation example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in Tables 1 to 3.
In addition, the dentifrice composition was adjusted so that pH in 25 degreeC might be set to 7.0.

<Evaluation method>
(1) Evaluation method of dentinal tubule sealing effect According to the method of Pashley et al. (J. Dent. Res. 57, 187-193, 1987), the permeability of dentinal tubule fluid was measured, and dentinal tubules by each dentifrice composition The degree of blockade of was evaluated.
A dentin block was cut out from a human tooth root and polished with water-resistant abrasive paper # 2000 to prepare a sample, which was used as a sample. 3 g of dentifrice composition and 6 g of artificial saliva of pH 7.0 containing 1 mM of CaCl ₂ and 3 mM of KH ₂ PO ₄ were mixed to make a 3-fold dilution, and the supernatant obtained by centrifugation was treated with the treatment liquid. did. The 3-fold dilution is based on the assumption that the dentifrice composition is diluted with saliva when brushing. The sample was immersed in this treatment solution for 1 minute, rinsed with distilled water, and then immersed in the artificial saliva at 37 ° C. for 12 hours. The same operation was performed twice a day, and this series of operations was repeated for a total of 5 days. Rinse the sample thoroughly with distilled water on the last day, and after drying, fix the sample, flush saline under constant pressure, measure the amount of saline per unit time passing through the sample, and treat with the treatment solution before treatment The permeability suppression rate with respect to the passage amount was calculated (the following formula). Evaluation was performed at n = 3, and the average value was adopted.
Passability suppression rate (%) =
((Amount of fluid before treatment -Amount of fluid after treatment) / (Amount of fluid before treatment)) × 100
Passage volume: Saline volume (μL) passing in 10 minutes

The degree of dentinal tubule sealing was judged from the average value of the obtained permeability inhibition rate according to the following evaluation criteria, and the dentinal tubule sealing effect was evaluated.
Evaluation criteria for ivory tubule sealing effect;
A: The permeability inhibition rate is 90% or more. O: The permeability inhibition rate is 80% or more and less than 90%. Δ: The permeability inhibition rate is 60% or more and less than 80%. X: The permeability inhibition rate is 60. Less than%

(2) Evaluation method of pH reduction inhibitory effect The pH after measuring the pH at 25 ° C. immediately after production of the dentifrice composition, filling the dentifrice composition in a laminate tube 50 g, and storing at 50 ° C. for 1 month. Was measured (value at 25 ° C.).
The amount of change in pH was calculated from the following formula, and the effect of suppressing the decrease in pH was determined according to the following evaluation criteria.
pH change =
(PH of dentifrice composition immediately after preparation) − (pH of dentifrice composition after storage at 50 ° C. for 1 month)
Evaluation criteria for inhibitory effect on pH decrease;
◎: pH change amount is less than 0.5 ○: pH change amount is 0.5 or more and less than 1.0 △: pH change amount is 1.0 or more and less than 1.5 ×: pH change amount is 1.5 or more

(3) Evaluation method of use feeling (3-1) No metallic taste Ten subjects examined the metallic taste when taking about 1 g of a dentifrice composition on a toothbrush and brushing for 3 minutes according to the following rating criteria. .
Rating criteria for lack of metal taste;
5 points: I do not feel at all 4 points: I feel a little 3 points: I feel 2 points: I feel strongly 1 point: I feel very strong The average value of 10 people was determined, and the lack of metallic taste was determined according to the following evaluation criteria.
Evaluation criteria for lack of metal taste;
◎: Average score of 10 people is 4.0 points or more ○: Average score of 10 people is 3.0 points or more and less than 4.0 points △: Average score of 10 people is 2.0 points or more and less than 3.0 points × : Average score of 10 people is less than 2.0

(3-2) No Oil Feeling About 10 g of the dentifrice composition was put on a toothbrush, and 10 subjects determined the oil feeling when brushing for 3 minutes according to the following rating criteria.
Grade criteria for lack of oil;
5 points: Not felt at all 4 points: Feels slightly 3 points: Feels 2 points: Feels strongly 1 point: Feels very strongly 10 averages were obtained and the lack of oil feeling was judged according to the following evaluation criteria.
Evaluation criteria for lack of oil feeling;
◎: Average score of 10 people is 4.0 points or more ○: Average score of 10 people is 3.0 points or more and less than 4.0 points △: Average score of 10 people is 2.0 points or more and less than 3.0 points × : Average score of 10 people is less than 2.0

Details of the raw materials used are shown below.
(A) Aluminum lactate; Musashino Chemical Laboratory Co., Ltd. (B) Sodium pyrophosphate; Taihei Chemical Industrial Co., Ltd. (B) Sodium tripolyphosphate; Taihei Chemical Industrial Co., Ltd. (C) α-olefin sulfonic acid Sodium: Lion Specialty Chemicals Co., Ltd. (D) Potassium nitrate; Otsuka Chemical Co., Ltd.

The following are examples of prescriptions. The raw materials used are the same as described above, and the pH of the preparation at 25 ° C. is in the range of 5-10.

[Formulation Example 1] Dentifrice (A) Aluminum lactate 2
(B) Sodium pyrophosphate 0.5
(C) Sodium α-olefin sulfonate 1
(D) Potassium nitrate 5
Sodium fluoride 0.33
Silicic anhydride 18
Sodium lauryl sulfate 1.0
70% sorbit solution 25
Propylene glycol 3
Xanthan gum 0.8
Saccharin sodium 0.2
Fragrance 1.2
Water balance
Total 100.0%

[Prescription Example 2] Dentifrice (A) Aluminum lactate 1.5
(B) Sodium pyrophosphate 1
(C) Sodium α-olefin sulfonate 1
(D) Potassium nitrate 5
Sodium monofluorophosphate 1.1
Silicic anhydride 20
Sodium lauryl sulfate 1.5
70% sorbite solution 30
Propylene glycol 3
Xanthan gum 0.8
Saccharin sodium 0.3
Fragrance 1.4
Water balance
Total 100.0%

Claims

(A) 0.01-5% by mass of aluminum lactate, (B) 0.01-5% by mass of condensed phosphate, and (C) 0.1-3% by mass of α-olefin sulfonate. A dentifrice composition characterized by comprising
The dentifrice composition according to claim 1, wherein the condensed phosphate of component (B) is pyrophosphate or tripolyphosphate.
The dentifrice composition according to claim 1 or 2, wherein the (C) α-olefin sulfonate is an α-olefin sulfonate having 14 to 16 carbon atoms.
The dentifrice composition according to any one of claims 1 to 3, wherein (B) / (A) has a mass ratio of 0.005 to 50, and (C) / (A) has a mass ratio of 0.05 to 100. object.
The dentifrice composition according to any one of claims 1 to 4, further comprising (D) 0.1 to 7% by mass of potassium nitrate.
The dentifrice composition according to any one of claims 1 to 5, wherein the pH at 25 ° C is 5 or more.
The dentifrice composition according to any one of claims 1 to 6, which is prepared as a toothpaste.
(A) A dentifrice composition containing 0.01-5% by mass of aluminum lactate, (B) 0.01-5% by mass of condensed phosphate, and (C) 0.1% of α-olefin sulfonate. A method for suppressing the decrease in pH and the appearance of metallic taste in the dentifrice composition by blending ˜3 mass%.
9. The pH reduction and metallic taste of the dentifrice composition according to claim 8, wherein (B) / (A) is 0.005 to 50 in terms of mass ratio and (C) / (A) is in the range of 0.05 to 100. To suppress the expression of.
Furthermore, (D) The method for suppressing a decrease in pH and expression of metallic taste in a dentifrice composition according to claim 8 or 9, wherein 0.1 to 7% by mass of potassium nitrate is blended.
11. The method for suppressing pH reduction and expression of metallic taste in a dentifrice composition according to any one of claims 8 to 10, wherein the dentifrice composition has a pH of 5 or more at 25 ° C.
A method for suppressing a decrease in pH and expression of a metallic taste in a dentifrice composition according to any one of claims 8 to 11, which is prepared as a toothpaste.