JP7400266B2 - Oral composition - Google Patents

Description

The present invention relates to an oral composition suitable for suppressing or preventing hypersensitivity, which improves the dentinal tubule-sealing effect of a water-soluble aluminum compound, provides an immediate and excellent dentinal tubule-sealing effect that is stable even after storage.

Dentin hypersensitivity is a temporary condition that occurs when the enamel or cementum of the tooth disappears and the dentin is exposed, and this dentin is exposed to external stimuli such as temperature, chemical, mechanical, etc. It causes very unpleasant pain. The reason for this is thought to be that nerves are stimulated through the dentinal tubules. In order to alleviate, eliminate, or prevent the pain caused by hypersensitivity, it is effective to suppress or prevent the transmission of stimuli by blocking or narrowing the openings of the dentinal tubules. As preventive measures using oral hygiene products such as oral compositions such as dentifrices, methods such as blocking dentinal tubules and dulling nerves have been used.

When water-soluble aluminum compounds such as aluminum lactate are added to oral compositions such as dentifrice compositions, they exhibit the effect of suppressing or preventing hypersensitivity due to the dentinal tubule-sealing action of aluminum ions, and the number of times they are used in the oral cavity increases. The effect of sealing dentinal tubules increases each time the amount is increased, but the effect is still not sufficient when the number of times of use is small, and there has been a need for improvement in terms of immediate effect. In addition, oral compositions containing water-soluble aluminum compounds sometimes have a reduced dentinal tubule sealing effect after storage, and there is still room for improvement in terms of storage stability.

Patent Documents 1 to 7 propose techniques for imparting a dentinal tubule sealing effect by blending a water-soluble aluminum compound into an oral composition.
Patent Document 1 (Patent No. 6206153) discloses that the dentinal tubule sealing effect of aluminum lactate in a dentifrice composition is stably maintained even after storage by a combination system of sodium monofluorophosphate and sodium dihydrogen phosphate. In particular, Patent Document 2 (Japanese Patent Publication No. 06-29171) discloses that when hydroxyalkyl cellulose and carrageenan, and further aluminum hydroxide as an abrasive are added to an oral composition containing a soluble aluminum compound, the soluble aluminum compound is stably mixed. In Patent Documents 3 and 4 (Japanese Patent No. 2550909, Japanese Patent Publication No. 07-042219), it is shown that water-soluble aluminum compounds such as aluminum lactate are effective in closing dentinal tubule strictures, and that the effect is effective in specific cases. It is proposed to improve the condition using water-soluble phosphoric acid compounds. In Patent Document 5 (Japanese Patent No. 5790455), foaming is ensured by blending a specific water-soluble polymer such as xanthan gum, propylene glycol alginate, and a silica-based abrasive into an aluminum lactate-containing dentifrice composition. After use (twice a day), the effect of preventing hypersensitivity has been obtained. Patent Document 6 (Patent No. 6375350) improves the dentinal tubule sealing effect of aluminum lactate using a lactam compound, and Patent Document 7 (Patent No. 3152467) uses a water-soluble aluminum compound and a fluorine compound in a specific ratio. It is proposed to enhance the effect of suppressing dentin hypersensitivity. However, these patent documents do not mention the immediate effect of the dentinal tubule sealing effect.

Patent No. 6206153 Special Publication No. 06-29171 Patent No. 2550909 Special Publication No. 07-042219 Patent No. 5790455 Patent No. 6375350 Patent No. 3152467 Patent No. 5440150

The present invention was made in view of the above circumstances, and an object of the present invention is to provide an oral composition that improves the dentinal tubule sealing effect of a water-soluble aluminum compound and provides an immediate and excellent dentinal tubule sealing effect that is stable even after storage. With the goal.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) water-soluble aluminum salt is blended in a specific amount or more for the purpose of imparting a dentinal tubule-sealing effect, and (C) silica is used as an abrasive. When (B) a cationic polymer compound is blended into an oral composition containing specific substances such as, the dentinal tubule sealing effect of component (A) is improved, resulting in immediate and excellent dentinal tubule sealing that is stable even after storage. It has been found that the above-mentioned problems can be solved.

More specifically, in the oral composition, in order to prevent or suppress hypersensitivity by exerting the dentinal tubule sealing effect of a water-soluble aluminum compound such as aluminum lactate, it is necessary to exist in the form of free aluminum ions. is important. On the other hand, even if the amount of water-soluble aluminum compound added was increased, the immediate effect did not improve, and a decrease in the effect was observed after storage. It has become clear that this is one of the causes. Therefore, the present inventors focused on this point and conducted further studies with the aim of improving the effect. As a result, (A) a water-soluble aluminum salt and (C) a polishing agent selected from silica, calcium carbonate, and calcium phosphate were used. When one or more types of abrasives were combined together and further combined with (B) a cationic polymer compound, aluminum ions were more likely to be adsorbed to component (C) compared to other types of abrasives. Surprisingly, due to component (B), the aluminum ion of component (A) is not adsorbed to component (C), and its dentinal tubule-sealing effect is enhanced and quickly developed, thereby increasing the dentinal tubule-sealing effect. It has an improved immediate effect, can provide a high dentinal tubule sealing effect even with a relatively small number of uses, can maintain the effect stably even after storage, and can also provide a pleasant feeling of use. Ta.
The effect of the present invention is a specific effect that is obtained when component (B) is combined with components (A) and (C) in a specific amount or more of component (A).
As shown in the comparative example in Table 3 below, if component (B) is not blended, even if the cellulose derivative hydroxyethylcellulose is blended, the dentinal tubule sealing effect (after 5 cycles of the product immediately after manufacture) is lower. The immediate effect was poor in the case of ×, and the dentinal tubule sealing effect (after 5 cycles and 20 cycles of the product after preservation) was both poor in the stability of the effect after preservation (Comparative Examples 3 and 4). In addition, if the amount of component (A) is too small, even if component (B) is blended, the dentinal tubule sealing effect (after 5 cycles and 20 cycles of the product after storage) will both decrease after storage with × and become stable. The properties were poor (Comparative Example 2).
On the other hand, as shown in Examples in Tables 1 and 2 below, it contains components (A), (B), and (C) of the present invention, and the amount of component (A) is at least a specific value. The oral composition has a high dentinal tubule sealing effect (after 5 cycles and 20 cycles for the product immediately after manufacture) and a high dentinal tubule sealing effect (after 5 cycles and 20 cycles for the stored product), and has an immediate effect. It had excellent storage stability, and had a good taste (no metallic taste, no bitterness, no astringency).

In addition, Patent Document 8 (Japanese Patent No. 5440150) discloses that cationized cellulose is blended into an oral composition containing 1.0% by mass or less of aluminum lactate and sodium fluoride, and fluoride is applied to tooth surfaces. This invention improves the effect of promoting chemical deposition. In contrast, the present invention provides immediate effect and storage stability of the dentinal tubule sealing effect when the amount of the (A) component is 1.2% by mass or more by combining the (B) component with the (A) and (C) components. This is an improvement in

Therefore, the present invention provides the following oral composition.
[1]
(A) water-soluble aluminum salt,
(B) Contains a cationic polymer compound and (C) one or more selected from silica, calcium carbonate, and calcium phosphate, and the content of component (A) is 0.13 to 0.70% by mass as aluminum ions. An oral composition characterized by:
[2]
(A) The oral composition according to [1], wherein the water-soluble aluminum salt is one or more selected from aluminum lactate, aluminum chloride, and potassium aluminum sulfate.
[3]
(B) The oral composition according to [1] or [2], wherein the cationic polymer compound is one or more selected from cationized cellulose and cationized guar gum.
[4]
The oral composition according to any one of [1] to [3] , wherein the content of component (C) is 30% by mass or less .
[5]
The oral composition according to any one of [1] to [4], wherein the content of component (B) is 0.04 to 1% by mass, and the content of component (C) is 3 to 30% by mass.
[6]
The oral composition according to any one of [1] to [5], further comprising (D) a water-soluble fluorine compound.
[7]
(D) The oral composition according to [6], wherein the water-soluble fluorine compound is sodium monofluorophosphate, and the content thereof is 0.1 to 5% by mass.
[8]
The oral cavity composition according to any one of [1] to [7], which is a dentifrice composition.
[9]
The oral composition according to any one of [1] to [8], which is used for suppressing or preventing hypersensitivity.

According to the present invention, the water-soluble aluminum compound improves the dentinal tubule sealing effect, provides an immediate and excellent dentinal tubule sealing effect that is stable even after storage, has good taste, and is suitable for suppressing or preventing hypersensitivity. It is possible to provide a composition for oral cavity.

The present invention will be explained in more detail below. The oral composition of the present invention contains (A) a water-soluble aluminum salt, (B) a cationic polymer compound, and (C) one or more selected from silica, calcium carbonate, and calcium phosphate.

(A) Water-soluble aluminum salt is a component that exhibits a dentinal tubule sealing effect.
The water-soluble aluminum salt may be any salt as long as it has a dentinal tubule sealing effect, and examples thereof include aluminum lactate, aluminum chloride, potassium aluminum sulfate, etc., and one or more of these can be used. Among them, aluminum lactate and aluminum chloride are preferred, and aluminum lactate is more preferred. Commercially available products can be used for these.

From the viewpoint of dentinal tubule sealing effect and taste, the blending amount of component (A) is 0.1% (mass%, the same shall apply hereinafter) of the entire composition as the amount of aluminum ions, particularly 0.10 to 1%. is preferable, more preferably 0.11 to 0.95%, still more preferably 0.13 to 0.70%. If the amount of aluminum ions is less than 0.1%, the dentinal tubule sealing effect, especially its stability, will be poor. The effect of sealing dentinal tubules increases as the amount added increases, but if too much is added, it may develop its own metallic taste and affect the taste, and if it is less than 1%, the good taste cannot be maintained sufficiently. can.
Furthermore, the amount of water-soluble aluminum salt blended is preferably 1.2% or more of the entire composition, more preferably 1.2 to 11%, still more preferably 1.2 to 10%, and most preferably 1.5 to 10%. It is 7%.

(B) The cationic polymer compound enhances the dentinal tubule-sealing effect of component (A), particularly improves the immediate effect, and maintains the dentinal tubule-sealing effect stably even after storage. .
(B) The cationic polymer compound is, for example, a cationized cellulose, a homopolymer of dimethyldiallylammonium, a copolymer of dimethyldiallylammonium chloride and a polymerizable monomer having an ethylenically unsaturated hydrocarbon group, or a cationized polyvinylpyrrolidone. , cationic polyamide, cationic polymethacrylate, cationic polyacrylamide, copolymer of cationic methacrylate and acrylamide, copolymer of cationic methacrylate and methacrylate, polyethyleneimide, cationic starch, cationic amylose, cationic guar gum, cationic roast Examples include bean gum, cationized agar, chitin, chitosan, and modified products thereof, and those having a nitrogen content of 0.1 to 3% are preferred. These can be used alone or in combination of two or more. Among these, cationized cellulose and cationized guar gum are preferred, and cationized cellulose is more preferred.

Cationized cellulose includes, for example, hydroxyethylcellulose dimethyldiallylammonium salt such as hydroxyethylcellulose dimethyldiallylammonium chloride, which is obtained by graft polymerizing dimethyldiallylammonium salt onto hydroxyethylcellulose, and O chloride which is obtained by bonding 2,3-epoxypropyltrimethylammonium chloride to hydroxyethylcellulose. -[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose and the like. Among these, hydroxyethylcellulose dimethyldiallylammonium salt, O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride, and especially hydroxyethylcellulose dimethyldiallylammonium salt are preferred.
Examples of the cationized guar gum include chlorinated O-[2-hydroxy-3-(trimethylammonio)propyl]guar gum.

(B) A commercially available product can be used as the cationic polymer compound. Specifically, hydroxyethylcellulose dimethyldiallylammonium chloride is manufactured by Akzo Nobel Co., Ltd., such as Cellcoat L-200 and Cellcoat H-100, and O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride is Examples include Leoguard MGP manufactured by Lion Corporation. Examples of O-[2-hydroxy-3-(trimethylammonio)propyl]guar gum chloride include Jaguar C-17 manufactured by Sansho Co., Ltd.

(B) The blending amount of the cationic polymer compound is preferably 0.04 to 1%, more preferably 0.05 to 0.7%, and even more preferably 0.3 to 0.7% of the total composition. be. When the blending amount is 0.04% or more, the immediate effect and stability of the dentinal tubule sealing effect are sufficiently improved. As the amount added increases, the immediate effect of the dentinal tubule sealing effect increases, and the effect is maintained more stably even after storage, but if too much is added, it may produce its own bitter taste, so 1% or less is sufficient. It suppresses bitterness and retains good taste.

Component (C) is one or more selected from silica, calcium carbonate, and calcium phosphate, and these are abrasives.
Examples of silica include abrasives containing silica (silicic anhydride), such as silica-based abrasives such as silica gel, precipitated silica, zirconosilicate, and aluminosilicate, and metals such as aluminum and zirconium that contain silica. Metal composite silica further containing these may be used. In the component (C) according to the present invention, "silica" means an abrasive containing the above-mentioned silica (silicic anhydride).
Examples of calcium carbonate include calcium carbonate-based abrasives such as light calcium carbonate and heavy calcium carbonate, and these can be used.
Examples of calcium phosphate include calcium phosphate-based abrasives such as dicalcium phosphate dihydrate, dicalcium phosphate anhydrate, and calcium pyrophosphate, which may be used.
These can be used alone or in combination of two or more. Commercially available products can be used for these.
As component (C), silica-based abrasives and calcium carbonate-based abrasives are particularly preferred from the viewpoint of immediate dentinal tubule sealing effect, and the immediate effect of dentinal tubule sealing effect and the improvement of dentinal tubule sealing effect after repeated use. From this point of view, silica-based abrasives are particularly preferred.

The blending amount of component (C) is preferably 30% or less of the entire composition, more preferably 25% or less, and still more preferably 15% or less. The lower limit is not particularly set, but from the point of view of cleaning experience, it is preferably 3% or more, more preferably 5% or more. If too much is added, the immediate effect of the dentinal tubule sealing effect, especially after storage, may be reduced. If the amount is 30% or less, the immediate effect and stability of the dentinal tubule sealing effect are sufficiently excellent.

In the present invention, it is preferable to further include (D) a water-soluble fluorine compound. When component (D) is combined with component (B), component (D) enhances the effect of improving the dentinal tubule sealing effect of component (B), improving the immediate effect and stability of the effect, especially on dentinal dentin after storage. It has the effect of further improving the immediate effect of the capillary sealing effect.
Examples of water-soluble fluorine compounds include sodium monofluorophosphate, sodium fluoride, potassium fluoride, ammonium fluoride, tin fluoride, amine fluoride, potassium monofluorophosphate, and sodium silicon fluoride, but preferably These include sodium monofluorophosphate and sodium fluoride, with sodium monofluorophosphate being particularly preferred.

The blending amount of component (D) is adjusted depending on the substance used. When sodium monofluorophosphate is blended as component (D), the blending amount is preferably 0.1 to 5% of the entire composition, and more It is preferably 0.5 to 3%, more preferably 1 to 2%.
Furthermore, when sodium fluoride is blended as component (D), the blending amount is preferably 0.05 to 3%, more preferably 0.1 to 1% of the total composition.
When the amount of component (D) is within the above range, the dentinal tubule sealing effect is sufficiently enhanced and the astringency and bitterness are sufficiently suppressed to maintain a pleasant feeling of use.

The oral composition of the present invention is particularly suitable as a dentifrice composition such as toothpaste. Furthermore, in addition to the above-mentioned components, other known components may be blended as needed within a range that does not impede the effects of the present invention. For example, a toothpaste can contain surfactants, binders, wetting agents, sweeteners, preservatives, colorants, fragrances, pH adjusters, medicinal ingredients, and the like. Incidentally, the blending amount may be a normal amount within a range that does not impede the effects of the present invention.

As the surfactant, anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants can be blended.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, acyl taurine salts such as sodium lauroylmethyltaurate, acyl sarcosinates, and acyl amino acid salts.
Examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, etc. Examples include polyoxyethylene fatty acid ester, polyoxyethylene higher alcohol ether, and fatty acid alkanolamide.
Examples of cationic surfactants include alkyl ammonium types and alkylbenzylammonium salts, and examples of amphoteric surfactants include betaine types, imidazoline types, and imidazolium betaine types.
The amount of surfactant to be blended is usually 0.001 to 10%, particularly 0.1 to 5% of the total composition.

The binder may contain an organic binder or an inorganic binder other than component (B). Specific examples of the organic binder include cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, and hydroxymethylcellulose, alginic acid derivatives, gums such as xanthan gum, carrageenan, polyvinyl alcohol, and sodium polyacrylate. Examples of the inorganic binder include thickening silica and thickening aluminum silica. The blending amount of these binders is usually 0.1 to 10% by weight, particularly 0.5 to 5% by weight, based on the total composition. In the present invention, organic binders are particularly preferred in terms of effectiveness, and the amount of organic binders to be blended is preferably 0.1 to 5%, particularly 0.5 to 3%, based on the total composition.

Examples of wetting agents include sugar alcohols such as sorbitol and xylit, and polyhydric alcohols such as glycerin and propylene glycol. The amount of wetting agent incorporated is usually 5 to 50%, particularly 20 to 45% of the total composition.

Examples of sweeteners include sodium saccharin.
Examples of the preservative include paraoxybenzoic acid ester, benzoic acid, or a salt thereof.
Examples of the coloring agent include Blue No. 1, Yellow No. 4, and titanium dioxide.

Fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime. Oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil Natural fragrances such as , yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, etc., and processing of these natural fragrances (front distillation cut, rear distillation cut, fractional distillation, liquid-liquid extraction, essence formation, powder fragrance) menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linaryl acetate, limonene, menthone , menthyl acetate, N-substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl Individual fragrances such as phenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethylthioacetate, as well as strawberry flavor, apple flavor, and banana flavor. , pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, mixed fruit flavor, tropical fruit flavor, and other known flavor materials used in oral compositions can be used in combination.
Although the blending amount of the fragrance is not particularly limited, it is preferable that the above-mentioned fragrance material is used in the composition in an amount of 0.000001 to 1%, and the fragrance using the above-mentioned fragrance material is used in the composition in an amount of 0.000001 to 1%. It is preferred to use 1-2%.

A pH adjuster may be added, and examples thereof include alkali metal hydroxides such as sodium hydroxide, hydrogen carbonates, carbonates, and the like.

The medicinal ingredients are generally known active ingredients, such as nonionic bactericidal agents such as isopropylmethylphenol, cationic bactericidal agents such as cetylpyridinium chloride, anti-inflammatory agents such as tranexamic acid and allantoin, and dextra. Examples include enzymes such as enzymes such as enzymes, water-soluble phosphoric acid compounds, inorganic salts such as sodium chloride and potassium nitrate, vitamins such as ascorbic acid and tocopherol acetate, plant extracts, anti-tartar agents, and anti-plaque agents. The medicinal ingredients can be blended in an effective amount within a range that does not interfere with the effects of the present invention.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to Examples and Comparative Examples, but the present invention is not limited to the Examples below. In addition, in the following examples, % indicates mass % unless otherwise specified.

[Example, Comparative Example]
Dentifrice compositions (dentifrices) having the compositions shown in Tables 1 to 3 were prepared by conventional methods, used as test dentifrices, and evaluated by the following method. The results are also listed in Tables 1 to 3.

<Evaluation method of dentinal tubule sealing effect>
The dentin part of a human molar tooth cut into 1-2 mm pieces was polished on one side with a file, and the tooth section was etched by immersing it in a 37% phosphoric acid aqueous solution for 45 seconds, followed by washing with water and ultrasonic cleaning. (0 cycles). The dentin part of this human molar was prepared by diluting the test dentifrice supernatant (the test dentifrice was diluted 3 times with artificial saliva, stirred with a shaker for 10 minutes, and then centrifuged at 10,000 rpm for 10 minutes. ) (3-fold dilution of artificial saliva, immersion for 3 minutes), and after washing, immersion in artificial saliva for 10 minutes at 37°C was repeated 5 times (5 cycles). Thereafter, the dentinal tubules were photographed using a laser microscope. Furthermore, after repeating the above operation 20 times in total (20 cycles), the dentinal tubules were photographed in the same manner. The obtained image was divided into two tones, and the ratio of the open area of the dentinal tubules that were not blocked was determined using the following formula.
Percentage of dentinal tubule opening area (%) =
(Dentinal tubule opening area at 5th or 20th cycle/dentinal tubule opening area at 0th cycle) x 100
From the ratio of the dentinal tubule opening area obtained, the dentinal tubule sealing effect was evaluated based on the following evaluation criteria.
Evaluation criteria ◎◎: The ratio of the dentinal tubule opening area is less than 20%. ◎: The ratio of the dentinal tubule opening area is 20% or more and less than 30%. ○: The ratio of the dentinal tubule opening area is 30% or more and less than 50%. Yes △: The ratio of the dentinal tubule opening area is 50% or more and less than 60%. ×: The ratio of the dentinal tubule opening area is 60% or more. Using dentifrice compositions (products immediately after manufacture) and dentifrice compositions stored for one month at 50°C and 75% RH conditions (post-preservation products), the test was carried out after the completion of 5 cycles of the above operations and after completion of 20 cycles of operations. The results were shown as dentinal tubule sealing effect (product immediately after manufacture, after 5 cycles or 20 cycles) and dentinal tubule sealing effect (product after storage, after 5 cycles or 20 cycles).
The immediate effect was determined from the evaluation results after 5 cycles of operation, and the stability of the effects was determined by comparing the evaluation results after 20 cycles of the product immediately after production and the product after storage.

<How to evaluate usability>
Five test subjects (expert panelists n=5) evaluated the usability of the product samples immediately after manufacture. 1 g of the sample was placed on a toothbrush (Clinica Advantage toothbrush, 4-row compact normal type), and teeth were brushed for 3 minutes. Immediately after rinsing, a questionnaire regarding the taste was conducted, and the taste was judged based on the following rating criteria. The average score of the five people was calculated, and the taste (lack of metallic taste, bitterness, and astringency) was evaluated using the following evaluation criteria.
Scoring criteria 1: Very strong metallic, bitter, or astringent taste 2: Very metallic, bitter, or astringent taste 3: Somewhat metallic, bitter, or astringent taste, but problematic No level 4: Almost no metallic taste, bitterness, or astringency 5: No metallic taste, bitterness, or astringency Evaluation criteria ◎: Average score of 5 people is 3.5 points or higher ○: Average of 5 people The score is 2.5 points or more and less than 3.5 points. △: The average score of 5 people is 2 points or more and less than 2.5 points. ×: The average score of 5 people is less than 2 points.

The following components (B) and (C) were used.
(B) Hydroxyethylcellulose dimethyldiallylammonium salt Hydroxyethylcellulose dimethyldiallylammonium chloride Manufactured by Akzo Nobel Co., Ltd., product name: Cellcoat L-200
(B) O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride manufactured by Lion Co., Ltd., trade name: Leogard MGP
(B) O-[2-hydroxy-3-(trimethylammonio)propyl] guar gum chloride manufactured by Sansho Co., Ltd., product name: Jaguar C-17
(C) Silicic anhydride Manufactured by Taki Chemical Co., Ltd., trade name: Silicic anhydride (C) Calcium carbonate, Calfine Co., Ltd., trade name: Heavy calcium carbonate (C) Calcium phosphate Manufactured by Tosoh Akzo Corporation , Product name: Dicalcium phosphate dihydrate

As shown in Table 3, Comparative Example 1 without component (A) and Comparative Examples 3 and 4 without component (B) both have dentinal tubule sealing effect (product immediately after manufacture, after 5 cycles) and dentinal tubule sealing effect (product immediately after manufacture, after 5 cycles). The sealing effect (after storage, after 5 cycles, after 20 cycles) was low, and the immediate effect and stability were poor. In addition, even though components (A), (B), and (C) are blended, Comparative Example 2, which has a small amount of component (A), has a low dentinal tubule sealing effect (product after preservation, after 5 cycles, after 20 cycles). A decrease was observed, and the stability of the effect was poor.
On the other hand, as shown in Tables 1 and 2, a dentifrice composition (Example) containing component (A) in a specific amount or more and a combination of components (B) and (C) It has a high tubule sealing effect (immediately manufactured product, after 5 cycles, 20 cycles) and dentinal tubule sealing effect (preserved product, after 5 cycles, after 20 cycles), has excellent immediate effect and stability, and has excellent taste. It had a good usability. Furthermore, when component (D) was added, the dentinal tubule sealing effect was further enhanced, and the effect was more immediate and stable.

Claims (6)

(A) water-soluble aluminum salt,
(B) contains one or more cationic polymer compounds selected from cationized cellulose and cationized guar gum, and (C) one or more selected from silica, calcium carbonate, and calcium phosphate, and the content of component (A) is The content of aluminum ions is 0.13 to 0.70% by mass, the content of component (B) is 0.04 to 1% by mass, and the content of component (C) is 3 to 30% by mass. Characteristic composition for oral cavity. The oral composition according to claim 1, wherein the water-soluble aluminum salt (A) is one or more selected from aluminum lactate, aluminum chloride, and potassium aluminum sulfate. The oral composition according to claim 1 or 2, further comprising (D) a water-soluble fluorine compound. The oral composition according to claim 3 , wherein the water-soluble fluorine compound (D) is sodium monofluorophosphate, and the content thereof is 0.1 to 5% by mass. The oral composition according to any one of claims 1 to 4 , which is a dentifrice composition. The oral composition according to any one of claims 1 to 5 , which is used for suppressing or preventing hypersensitivity.