JP2014139162A - Dentifrice composition and teeth dentinal tubule blocking agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition and a teeth dentinal tubule blocking agent which improve ability of dentinal tubule blocking, stably maintain high dentinal tubule blocking effect after storage, and contain aluminium lactate effective for the prevention of hyperesthesia.SOLUTION: A dentifrice composition comprises: (A) sodium monofluorophosphate; (B) sodium dihydrogen phosphate; and (C) aluminium lactate, and the mass ratio of ((A) component+(B) component)/(C) component) is 0.10 to 1.0. The dentifrice composition also comprises (D) coconut oil fatty acid amidopropyl betaine. A teeth dentinal tubule blocking agent comprises the (A), (B) and (C) components, and the mass ratio of ((A) component+(B) component)/(C) component) is 0.10 to 1.0. The teeth dentinal tubule blocking agent also comprises the (D) component.

Description

  The present invention relates to an aluminum lactate-containing dentifrice that improves the ability of dentinal tubules to seal and constrict the opening of dentinal tubules, maintains a high dentinal tubule sealing effect even after storage, and is effective in preventing hypersensitivity The present invention relates to a composition and a dental dentinal tubule sealant.

  Hypersensitivity is a very unpleasant pain caused by various external stimuli due to exposure of dentin. To alleviate, eliminate, or prevent this hypersensitive pain, ivory It is effective to suppress and prevent the transmission of stimulation by blocking and constricting the opening of the capillary tube.

Aluminum lactate has the effect of blocking and constricting the opening of the dentinal tubule, and many techniques for preventing hypersensitivity of dentin by blending this aluminum lactate into the oral composition have been proposed. A technique that contains aluminum lactate and a phosphate compound to prevent hypersensitivity is known. Patent Document 1 (Japanese Patent Application Laid-Open No. 7-165550) discloses that the effect of stenosis or closure of dentinal tubules can be improved by blending an oral composition with a dentinal tubule stenosis closure active ingredient such as aluminum lactate. Has been proposed. Patent Document 2 (Japanese Patent Application Laid-Open No. 61-155314) discloses a composition for oral cavity which can be suitably used for the prevention and treatment of dentin hypersensitivity by stably containing an aluminum lactate compound. A toothpaste containing disodium hydrogen phosphate and sodium monofluorophosphate, and Example 6 discloses a toothpaste containing aluminum lactate and disodium hydrogen phosphate.
In addition, a composition for oral cavity in which the effect of suppressing hypersensitivity to dentin is improved by blending aluminum lactate and fluoride and the pH of the composition is in a specific range is proposed in Patent Document 3 (Patent No. 3152467). ing.
These Patent Documents 1 to 3 are improvements in dentinal tubule stenosis or closure effect after treatment, and no mention is made of the dentinal tubule sealing effect after storage.

Japanese Patent Laid-Open No. 7-165550 JP 61-155314 A Japanese Patent No. 3152467

  However, in an aluminum lactate-containing dentifrice composition, there is still room for improvement in the ability of dentinal tubules to seal and constrict the opening of the dentinal tubules, and in particular, there is a problem in the ability to seal dentinal tubules over time, When a relatively large amount of aluminum lactate is added to increase its effectiveness, problems may arise in stability and taste. Therefore, the improvement of the dentinal tubule sealing ability over time of the dentifrice composition containing aluminum lactate has been a problem.

  The present invention has been made in view of the above circumstances, and has an aluminum lactate-containing dentifrice composition that improves dentinal tubule sealing ability, maintains a high dentinal tubule sealing effect even after storage, and is effective in preventing hypersensitivity. It is an object of the present invention to provide a dentinal tubule sealant for objects and teeth.

  As a result of intensive studies to achieve the above object, the present inventors formulated (A) sodium monofluorophosphate, (B) sodium dihydrogen phosphate and (C) aluminum lactate, and (A) component And the total compounding quantity of (B) component is an appropriate ratio with respect to the compounding quantity of (C) component, the dentinal tubule sealing ability which seals and narrows the opening part of a dental dentinal tubule improves, and dentinal tubule sealing It was found that the effect was excellent and the high dentinal tubule sealing effect was maintained stably after long-term storage. Furthermore, it was found that when (D) coconut oil fatty acid amidopropyl betaine is further blended, the unpleasant taste derived from aluminum lactate is improved.

  In the present invention, by properly combining aluminum lactate, sodium monofluorophosphate, and sodium dihydrogen phosphate, the ability to seal dentinal tubules is remarkably improved, and as shown in the examples described later, the liquid permeability control rate 80 % Or more, particularly 90% or more of the dentinal tubule-sealing effect, and such a high dentinal tubule-sealing effect is stably maintained at a high temperature of 40 ° C. without decreasing after storage for 6 months. In this case, by combining sodium monofluorophosphate and sodium dihydrogen phosphate, both components unexpectedly act specifically and can maintain the dentinal tubule sealing ability stably over time. It is possible to give the above-mentioned special effects that cannot be achieved with sodium or sodium dihydrogen phosphate alone. Moreover, the improvement of the dentinal tubule sealing ability over time as described above cannot be imparted with disodium hydrogen phosphate and trisodium phosphate belonging to the sodium salt of orthophosphoric acid. This is due to a specific action.

  Furthermore, in the present invention, (D) by adding palm oil fatty acid amidopropyl betaine, it is derived from the excretion of aluminum lactate and metallic taste in a system in which components (A), (B), and (C) are used in combination. You can improve the feeling of use by suppressing the unique taste.

Accordingly, the present invention provides the following dentifrice composition and tooth dentinal tubule sealant.
[1]
(A) Sodium monofluorophosphate, (B) Sodium dihydrogen phosphate and (C) Aluminum lactate, ((A) component + (B) component) / (C) component is 0.10 as a mass ratio. The dentifrice composition characterized by being -1.0.
[2]
The dentifrice composition according to [1], containing 0.3 to 1% by mass of component (A), 0.01 to 0.2% by mass of component (B), and 1 to 5% by mass of component (C). .
[3]
The dentifrice composition according to [1] or [2], further comprising (D) a palm oil fatty acid amidopropyl betaine.
[4]
(D) Dentifrice composition as described in [3] which contains 0.1-2 mass% of components.
[5]
The dentifrice composition according to any one of [1] to [4], which is for hypersensitivity.
[6]
(A) Sodium monofluorophosphate, (B) Sodium dihydrogen phosphate, and (C) Aluminum lactate, where ((A) component + (B) component) / (C) component is 0.10 as a mass ratio. -1.0 dental dentinal tubule sealant.
[7]
Furthermore, the tooth dentinal tubule sealant according to [6], further comprising (D) a palm oil fatty acid amidopropyl betaine.

  According to the present invention, the dentin tubule sealing ability is improved, the dentinal tubule sealing effect is excellent, and the high dentinal tubule sealing effect is stably maintained even after long-term storage, and is an aluminum lactate-containing dentifrice effective in preventing hypersensitivity A composition and a dental dentinal tubule sealant can be provided.

  The present invention will be described in further detail below. The dentifrice composition of the present invention contains (A) sodium monofluorophosphate, (B) sodium dihydrogen phosphate, and (C) aluminum lactate, and the blending ratio of these components is in a specific range. And

(A) As sodium monofluorophosphate, commercially available products such as those manufactured by Rhodia Nikka Co., Ltd. can be used.
The blending amount of sodium monofluorophosphate is preferably 0.3 to 1% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.6 to 1.0%. The amount of dentinal tubule sealing increases as the blending amount increases, and if it is 0.3% or more, the dentinal tubule sealing effect can be sufficiently obtained, but if it is 1% or less, the dentinal tubule sealing effect over time is sufficient. It is suitable for obtaining.

  The component (B) is sodium dihydrogen phosphate, and a commercial product manufactured by Taihei Chemical Industry Co., Ltd. can be used. Even if disodium hydrogen phosphate or trisodium phosphate is used in place of the component (B) sodium dihydrogen phosphate, the effect of sealing the dentinal tubule over time is not improved and the object of the present invention is not achieved.

  The blending amount of sodium dihydrogen phosphate is preferably 0.01 to 0.2% of the entire composition. When the blending amount is 0.01% or more, the dentinal tubule sealing effect can be sufficiently obtained, and when it is 0.2% or less, it is suitable for sufficiently obtaining the dentinal tubule sealing effect over time. .

(C) The aluminum lactate can use a commercial item, for example, the thing made by Musashino Chemical Co., Ltd. can be used.
The blending amount of aluminum lactate is preferably 1 to 5%, more preferably 2 to 5% of the entire composition. It is more suitable for the improvement of dentinal tubule sealing ability that a compounding quantity exists in the said range. If the blending amount is less than 1% or more than 5%, the dentinal tubule sealing ability may not be sufficiently improved.

  In the present invention, it is important for the effect expression that (A) component + (B) component) / (C) component indicating the blending ratio of components (A), (B), (C) is in a specific range. Yes, the specific ratio of the three components acts specifically, and the dentinal tubule sealing ability with time is improved. ((A) component + (B) component) / (C) component is 0.10-1.0 as mass ratio, Preferably it is 0.2-1.0, More preferably, it is 0.3-0. 6, More preferably, it is 0.3-0.5. If the blending ratio is less than 0.10 or greater than 1.0, the dentinal tubule sealing ability is not improved and the dentinal tubule sealing effect over time cannot be obtained.

The composition of the present invention preferably further contains (D) coconut oil fatty acid amide propyl betaine, and this can improve taste.
Coconut oil fatty acid amidopropyl betaine is amidopropyl betaine made from coconut oil fatty acid containing saturated fatty acids such as lauric acid, myristic acid and palmitic acid. For example, commercially available products such as TEGO Betaine CK OK (30% aqueous solution) manufactured by Degussa Co., Ltd. and Anhitol 55AB (30% aqueous solution) manufactured by Kao Corporation can be used, and these commercially available products can be used. In place of coconut oil fatty acid amide propyl betaine, even when amide propyl betaine other than coconut oil fatty acid is used as a raw material, for example, lauric acid amide propyl betaine or the like, bitterness is produced, and taste amelioration cannot be improved.

  When the coconut oil fatty acid amidopropyl betaine is blended, the blending amount is preferably 0.1 to 2%, more preferably 0.1 to 1% of the total composition in terms of pure content. If the blending amount is 0.1% or more, the sashimi is eliminated and the effect of improving the taste can be given. If the blending amount is 2% or less, the occurrence of the bitterness derived from the coconut oil fatty acid amidopropyl betaine can be suppressed. it can.

  The dentifrice composition of the present invention is prepared as a toothpaste, a liquid dentifrice, a liquid dentifrice, a moisturizing dentifrice or the like. Moreover, in addition to the said component, the well-known component according to a dosage form can be mix | blended as needed in the range which does not prevent the effect of this invention. For example, toothpastes can contain abrasives, thickeners, binders, surfactants, and if necessary, flavorings, sweeteners, colorants, preservatives, active ingredients, and the like.

  Examples of the abrasive include silica-based abrasives such as silica gel and precipitated silica, dicalcium phosphate dihydrate and anhydrous, calcium phosphate-based abrasives such as tertiary calcium phosphate and tetrabasic calcium phosphate, calcium pyrophosphate, calcium carbonate, hydroxylated Examples thereof include aluminum, alumina, and synthetic resin abrasive. The blending amount of the abrasive is preferably 0 to 40%, particularly preferably 2 to 30% of the entire composition.

  Examples of the thickener include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as glycerin and propylene glycol. These compounding amounts are usually 5 to 50%, particularly 20 to 40%.

  Examples of the binder include cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, and hydroxypropylcellulose, gums such as xanthan gum and gum arabic, alginic acid derivatives, carrageenan, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone. Examples thereof include inorganic binders such as organic binders, gelling silica, and gelling aluminum silica. The amount is usually 0.1 to 10%.

As the surfactant, any surfactant usually used in dentifrice compositions may be used, and anionic surfactants, nonionic surfactants, cationic surfactants and the like can be blended, but sodium lauryl sulfate is suitably blended. it can.
Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, N-acyl sarcosine salts such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate Examples include sodium, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate, etc. .

Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, monolaurin Polyglycerin fatty acid esters such as hexaglyceryl acid, hexaglyceryl monomyristate, decaglyceryl monolaurate, decaglyceryl monomyristate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate Polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, and polyoxyethylene lauryl ether Polyoxyethylene higher alcohol ethers, fatty acid alkanolamides, such as lauric acid diethanolamide, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid esters.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.
The compounding quantity of surfactant, especially sodium lauryl sulfate is 0.1 to 5.0% normally.

  As a fragrance | flavor, the well-known fragrance | flavor used normally can be mix | blended suitably. Specifically, peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, Sweet oil, cocoon oil, Iris concrete, absolute peppermint, absolute rose, orange flower and other natural fragrances, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence conversion) Fragrance, powdered fragrance, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-1-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Single-flavored ingredients such as o-acetate, as well as fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, and dentifrice composition It can be used in combination with known perfume materials used in the above.

Examples of the sweetener include saccharin sodium, stevioside, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, and perilartin.
Examples of the colorant include Blue No. 1, Yellow No. 4, titanium dioxide, and the like. Examples of the preservative include paraoxybenzoic acid esters such as methylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof. .

  As the active ingredient, known ingredients other than sodium monofluorophosphate and aluminum lactate can be blended. For example, nonionic fungicides such as isopropylmethylphenol, cationic fungicides such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, allantoin, glycyrrhetinic acid, glycyrrhizic acid , Enzymes such as dextranase, mutanase, amylase, protease, lysozyme, fluorides such as sodium fluoride, water-soluble phosphate compounds such as potassium salt of orthophosphate, copper compounds such as copper gluconate, copper chlorophyllin sodium, Inorganic salts such as sodium chloride, potassium nitrate, zinc chloride, zinc citrate, and strontium chloride, vitamins such as ascorbic acid and tocopherol acetate, chlorophyll, soft bean extract, thyme, ogon, clove, hamamelis, etc. Things extract, anti-tartar agents and antiplaque agents. These active ingredients can be blended in an effective amount as long as the effects of the present invention are not hindered.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in Tables 1-3.

<Evaluation of ivory tubule sealing ability>
According to the method of Pashley et al. (J. Dent. Res. 57, 187-193, 1987), the permeability of the dentinal tubule was measured, and the degree of occlusion of the dentinal tubule by each dentifrice composition was evaluated.
A dentin block was cut out from a human tooth root and polished with water-resistant abrasive paper # 2000 to prepare a sample, which was used as a sample. 3 g of the dentifrice composition and 6 g of artificial saliva of pH 7.0 containing 1 mM of CaCl ₂ and 3 mM of KH ₂ PO ₄ were mixed to obtain a 3-fold dilution, and the supernatant obtained by centrifugation was treated liquid. It was. The 3-fold dilution is based on the assumption that the dentifrice composition is diluted with saliva during brushing. The sample was immersed in this treatment solution for 1 minute, rinsed with distilled water, and then immersed in the artificial saliva at 37 ° C. for 12 hours. The same operation was performed twice a day, and this series of operations was repeated for a total of 5 days. Rinse the sample thoroughly with distilled water on the last day, and after drying, fix the sample, flush saline under constant pressure, measure the amount of saline per unit time passing through the sample, and treat with the treatment solution before treatment The permeability suppression rate of each Example and the comparative example with respect to the passage amount was calculated (the following formula (1)). In each example (Example, Comparative Example), the evaluation was performed with n = 3, and the average value was adopted.

The degree of dentinal tubule sealing of each example was judged from the average value of the obtained permeability inhibition rate according to the following criteria, and dentinal tubule sealing ability was evaluated. ○ The above was considered acceptable.
Evaluation criteria;
A: The permeability inhibition rate is 90% or more. O: The permeability inhibition rate is 80% or more and less than 90%. Δ: The permeability inhibition rate is 60% or more and less than 80%. X: The permeability inhibition rate is 60. Less than%

<Evaluation of dentinal tubule sealing ability over time>
The dentinal tubule sealing ability over time was operated and calculated in the same manner as the evaluation of the dentinal tubule sealing ability using the dentifrice composition after being stored at 40 ° C. for 6 months. Capillary blocking ability was evaluated.

Furthermore, about the Example of Table 2, it evaluated by the following method about unpleasant taste.
<Evaluation of bad taste>
About 1 g of the dentifrice composition was placed on a commercially available toothbrush and brushed for 3 minutes. The unpleasant taste felt during use was determined according to the following rating and evaluated according to the following evaluation criteria (n = 10).
Rating 4 points: No disgusting 3 points: Little disgusting 2 points: Some disgusting 1 point: Disgusting Evaluation criteria ◎: 3.5 points or more 4.0 points or less ○: 3.0 points or more 3 Less than 5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

Details of the raw materials used are as follows.
(A) Sodium monofluorophosphate; Rhodia Nikka Co., Ltd. (B) Sodium dihydrogen phosphate; Taihei Chemical Industry Co., Ltd. (C) Aluminum lactate; Musashino Chemicals Co., Ltd. sodium fluoride; Stellachemifa Disodium hydrogen phosphate manufactured by Taihei Chemical Industrial Co., Ltd. Trisodium phosphate manufactured by Taihei Chemical Industrial Co., Ltd.

＊：比較品との比率

*: Ratio to comparison product

Claims (7)

  (A) Sodium monofluorophosphate, (B) Sodium dihydrogen phosphate and (C) Aluminum lactate, ((A) component + (B) component) / (C) component is 0.10 as a mass ratio. The dentifrice composition characterized by being -1.0.   The dentifrice composition of Claim 1 which contains (A) component 0.3-1 mass%, (B) component 0.01-0.2 mass%, and (C) component 1-5 mass%.   The dentifrice composition according to claim 1 or 2, further comprising (D) a coconut oil fatty acid amidopropyl betaine.   The dentifrice composition of Claim 3 which contains 0.1-2 mass% of (D) component.   The dentifrice composition according to any one of claims 1 to 4, which is used for hypersensitivity.   (A) Sodium monofluorophosphate, (B) Sodium dihydrogen phosphate, and (C) Aluminum lactate, where ((A) component + (B) component) / (C) component is 0.10 as a mass ratio. -1.0 dental dentinal tubule sealant.   The tooth dentinal tubule sealant according to claim 6, further comprising (D) a palm oil fatty acid amidopropyl betaine.