JP2010037293A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dentifrice composition which is usable to prevent or treat various periodontal diseases by being formulated as a dentifrice of e.g., a soft paste type which exhibits sure antiseptic power, produces little foreign taste during use, is excellent in usability, is less stimulative to gingiva, and is easy to deliver medicinal ingredients even to the corners of the oral cavity. <P>SOLUTION: Titanium oxide and a cationic bactericide are formulated into a dentifrice composition having a water content of 45-70 mass% on condition that the titanium oxide content is 0.7-2 mass%. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention is a dentifrice composition having a high water content, especially prepared as a soft paste dentifrice, etc., which has a high antiseptic power and has a low taste during use, and has an excellent feeling of use. It relates to a dentifrice composition.

  With the increase in the number of patients with periodontal disease, a soft paste (soft paste type) dentifrice that is less irritating to the gums is required. Soft paste dentifrice has a high water content in the composition, so the viscosity of the formulation is low and the dispersibility in the oral cavity is high, so the burden on the gums is small and the medicinal ingredients are spread throughout the oral cavity. It is easy to get around.

  On the other hand, the soft paste dentifrice has a problem that the preservative power of the preparation is weak due to its large water content and is easily contaminated with various bacteria.

  As a method for enhancing the antiseptic power of dentifrice and preventing contamination of the preparation, it is common to add a preservative. As preservatives, paraoxybenzoic acid esters such as ethyl paraoxybenzoate, methyl paraoxybenzoate, and butyl paraoxybenzoate, sodium benzoate, potassium sorbate, sodium dehydroacetate, and the like are known.

  However, when a preservative such as p-hydroxybenzoate is added to the dentifrice, there is a problem that the feeling of use of the dentifrice, in particular, the taste is deteriorated. In particular, soft paste-type dentifrices have a high moisture content in the preparations compared to the normal moisture content of paste-like dentifrices such as toothpaste, which is about 15 to 50% by mass. Therefore, it is necessary to add a lot of preservatives in order to maintain the antiseptic power sufficiently, but if a sufficient amount of preservatives are added to fully exhibit the antiseptic power, There is a problem that the taste deteriorates and the usability is inferior.

  As a technique that does not contain a preservative such as paraoxybenzoic acid ester and ensures a sufficient antiseptic power, a method using a water-soluble calcium salt and a surfactant in combination (Patent Document 1; Japanese Patent Laid-Open No. 58-216115) And a method using a specific fragrance (Patent Document 2; JP 2001-302475 A) and the like are known. However, no matter which method is employed, sufficient antiseptic power is not exhibited in a dentifrice preparation with a high water content.

  On the other hand, cationic bactericides are blended in oral care products as an effective means of reducing the number of pathogenic bacteria in the oral cavity, and as a technique for improving the bactericidal effect, a specific nonionic surfactant is used. Oral compositions that exhibit an excellent bactericidal effect when used in combination (Patent Document 3; JP-A-11-255629, Patent Document 4; JP-A-2005-179266) have been proposed. However, it has been difficult to say that these techniques can satisfactorily increase the preservative power of a dentifrice composition having a high water content. In addition, the cationic bactericide also has a problem that the taste during use increases when it is blended in a dentifrice at a high concentration.

  For this reason, it has been difficult to satisfactorily satisfy both the antiseptic power and the feeling of use in a dentifrice such as a soft paste type having a large amount of water. Therefore, development of a technique capable of enhancing the antiseptic power of a preparation of a dentifrice composition having a high water content and maintaining a good feeling of use with almost no off-flavor is required.

  Titanium oxide has a very strong hiding power and is blended in many oral compositions as a white pigment for the purpose of preventing discoloration of the preparation (Patent Document 5; JP 2003-526649 A, Patent Document 6; Japanese Patent Application Laid-Open No. 2004-250381) does not show that the antiseptic power of the dentifrice composition is increased by the incorporation of titanium oxide.

JP 58-216115 A JP 2001-302475 A JP-A-11-255629 JP 2005-179266 A JP-T-2003-526649 Japanese Patent Laid-Open No. 2004-250381

  The present invention has been made in view of the above circumstances, and is a dentifrice composition having a high water content and prepared as a soft paste dentifrice, etc., having high antiseptic power of the preparation, and having an unpleasant taste during use. An object of the present invention is to provide a dentifrice composition that has almost no problem in use.

  As a result of intensive studies to achieve the above object, the present inventors have added titanium oxide and a cationic fungicide to a dentifrice composition having a moisture content of 45 to 70% (mass%, the same shall apply hereinafter). When the content of titanium oxide is 0.7-2%, the antiseptic power of the dentifrice preparation with a high moisture content is remarkably high, and it is good with almost no off-flavors during use. As a result, the present invention has been found.

  In the present invention, in a dentifrice composition having a high water content, especially prepared as a soft paste type dentifrice, etc., the water content is set to an appropriate amount, and titanium oxide and a cationic disinfectant are combined in combination. Thus, as will be apparent from the examples described later, these two components act synergistically, and even without adding a particularly large amount of cationic bactericidal agent, further, paraoxybenzoic acid ester, benzoic acid or a salt thereof. Even if it does not contain preservatives such as, antiseptic power is demonstrated, contamination by various bacteria can be effectively prevented, and there is almost no nasty taste during use, so in a dentifrice composition with a high water content, It is possible to achieve a special function and effect of having both high antiseptic power and excellent usability, and such a function and effect of the present invention has a cationic fungicide. Bacteria effect is considered to be derived from that improved by the presence of titanium oxide.

Accordingly, the present invention provides the following dentifrice composition.
(1) A dentifrice comprising a dentifrice composition having a moisture content of 45 to 70% and titanium oxide and a cationic bactericidal agent, wherein the titanium oxide content is 0.7 to 2%. Agent composition.
(2) The dentifrice composition according to (1), wherein the cationic bactericidal agent is at least one selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride.

  The dentifrice composition of the present invention ensures high antiseptic power, has almost no taste during use, has excellent usability, has little irritation to gingiva, and has medicinal ingredients in every corner of the oral cavity. It can be used to prevent or treat various periodontal diseases by preparing a soft paste type dentifrice that is easy to spread.

Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention has a moisture content of 45 to 70% and contains (A) titanium oxide and (B) a cationic fungicide. Thus, it is suitably prepared as a soft paste type toothpaste, liquid toothpaste and the like.
The soft paste type has a viscosity of 25 ° C. using a BH viscometer (manufactured by Toki Sangyo Co., Ltd., VISCOMETERTVB-10). A value obtained by measuring the viscosity after 3 minutes with 6 rotors and 20 rotations can be a paste-form preparation having a viscosity of 40 Pa · s or less.

  The water content in the dentifrice composition of the present invention is 45 to 70%, preferably 51 to 60%. If the water content is less than 45%, a soft paste type preparation may not be obtained, and if it exceeds 70%, sufficient preservative power of the preparation may not be obtained.

Titanium oxide includes two types, a rutile type and an anatase type, and a rutile type is particularly preferable. The average particle diameter is preferably 0.1 to 10 μm. In addition, an average particle diameter is a measured value of 50% particle diameter by a micro track particle size analyzer (made by Nikkiso Co., Ltd.).
Commercially available products can be used as titanium oxide, and specific examples include TIPAQUE manufactured by Ishihara Sangyo Co., Ltd. and TR-600 manufactured by Fuji Titanium Industrial Co., Ltd.

  The blending amount of titanium oxide is preferably 0.7 to 2%, particularly 0.9 to 1.5% of the entire composition. If it is less than 0.7%, sufficient preservative power of the preparation may not be obtained, and if it exceeds 2%, the taste during use may be deteriorated.

Examples of the cationic fungicide include alkyl pyridinium salts, benzyl long chain alkyl short chain dialkyl ammonium salts or derivatives thereof, and long chain alkyl short chain trialkyl ammonium salts. Specific examples of such cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyldimethylbenzylammonium chloride, lauryltrimethylammonium chloride, myristyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium. Among them, alkylpyridinium salts, particularly cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride are preferably used from the viewpoint of the antiseptic power of the dentifrice preparation and the taste during use.
As these cationic disinfectants, commercially available products available from reagent manufacturers such as Wako Pure Chemical Industries, Ltd., Kanto Chemical Co., Ltd., and Tokyo Chemical Industry Co., Ltd. can be used.

  The cationic bactericides may be used alone or in combination of two or more, but the blending amount is preferably 0.005 to 0.1%, particularly preferably 0.006 to 0.05% of the whole composition. If the blending amount is less than 0.005%, sufficient preservative strength of the preparation may not be obtained, and if it exceeds 0.1%, the taste during use may be deteriorated.

  The composition of the present invention may not contain any bactericidal component other than the cationic bactericidal agent, and in particular, paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, benzoic acid or Preservatives such as salts may not be added.

  In the dentifrice composition of the present invention, in addition to the above essential components, other additives can be blended as optional components depending on the dosage form as long as the effects of the present invention are not impaired. For example, when preparing a dentifrice of a soft paste type, abrasives, thickeners, binders, surfactants, sweeteners, active ingredients, pigments, fragrances, etc. can be blended, and these ingredients are mixed with water. Can be produced by conventional methods.

  As an abrasive | polishing agent, well-known abrasive | polishing agents other than a titanium oxide can be added. For example, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, calcium pyrophosphate, aluminum hydroxide, alumina, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate , Tertiary magnesium phosphate, zeolite, zirconium silicate, tertiary calcium phosphate, hydroxyapatite, fluoroapatite, calcium deficient apatite, tertiary calcium phosphate, fourth calcium phosphate, eighth calcium phosphate, synthetic resin abrasive, precipitated silica, silica gel , Aluminosilicate, zirconosilicate and the like. 5-50% of the whole composition is suitable for the compounding quantity of these abrasive | polishing agents.

  As the thickening agent, at least one of sugar alcohols such as glycerin, sorbit, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6000, ethylene glycol, reduced starch saccharified, and polyhydric alcohols can be used. Usually, the compounding quantity of these thickeners is 10 to 40% of the whole composition.

  Examples of binders include organic binders such as sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, sodium polyacrylate, xanthan gum, carbopol, guar gum, gelatin, and avicel, montmorillonite, and kaolin. And inorganic binders such as bentonite. Usually, the compounding quantity of these binders is 0.5 to 3% of the whole composition.

  As the surfactant, a known anionic surfactant, nonionic surfactant, or amphoteric surfactant can be added. Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, acyl sarcosine salts such as sodium lauroyl sarcosine, sodium myristyl sarcosine, polyoxyethylene alkyl sulfate, N-lauroyl taurate, α-olefin sulfonic acid Examples include salts. Nonionic surfactants include, for example, alkyl glycosides having 8 to 16 carbon atoms in the alkyl group, sucrose fatty acid esters having 12 to 18 carbon atoms in the fatty acid group such as sucrose mono or dilaurate, lactose fatty acid esters, Polyalkyl alcohol fatty acid esters such as lactitol fatty acid ester, maltitol fatty acid ester and stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, and alkyl such as lauroyl diethanolamide Roylethanolamide, polyoxyethylene polyoxypropylene glycol, decaglyceryl laurate and the like can be mentioned. Examples of the amphoteric surfactant include alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and the like.

  One or more surfactants as these optional components can be blended, and the blending amount is usually 0.1 to 3% with respect to the total amount of the composition.

  As a sweetening agent, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin and the like can be blended.

  As an active ingredient, in addition to a cationic disinfectant, various known active ingredients, for example, sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, monofluorolin Fluoride such as sodium phosphate, potassium phosphate of orthophosphoric acid, water-soluble phosphate compound such as sodium salt, tranexamic acid, epsilon-aminocaproic acid, allantochlorohydroxyaluminum, hinokitiol, ascorbic acid, sodium chloride, dl-tocopherol acetate, Chelating phosphate compounds such as dihydrocholesterol, α-bisabolol, triclosan, isopropylmethylphenol, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate, copper gluconate Copper compounds, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid or derivatives thereof, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, sodium chloride, dihydrocholesterol, trichlorocarbanilide And plant extracts such as zinc citrate, soft sugar beet extract, buckwheat extract, chamomile, clove, rosemary, hornon, safflower and the like. In addition, the addition amount of these active ingredients can be made into an effective amount in the range which does not prevent the effect of this invention.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Natural roses such as absolute rose and orange flower, and fragrances processed with these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid extraction, essence, powder fragrance, etc.), menthol, carvone , Anethole, cineol, methyl salicylate, syn Mic aldehyde, eugenol, 3-l-mentoxypropane-1.2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral , Pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, Isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl Single-flavored ingredients such as o-acetate, as well as fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, and dentifrice composition The well-known perfume material used for can be used, and it is not limited to the perfume of an Example.

  Moreover, although the compounding quantity of a fragrance | flavor is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

  As colorants, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 No. is exemplified. In addition, the compounding quantity of these components can be made into a normal quantity in the range which does not prevent the effect of this invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

Examples and comparative examples
A dentifrice composition (soft paste type) having the composition shown in Tables 1 and 2 was prepared by the following method, and a laminate tube (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30, having a thickness of 257 μm (Dai Nippon Printing Co., Ltd.) was filled with 50 g, and the antiseptic power of the dentifrice formulation and its taste during use were evaluated by the following methods. The results are shown in Tables 1 and 2.
In addition, the viscosity of the obtained dentifrice composition was 25 degreeC using a BH type viscometer (the Toki Sangyo Co., Ltd. make, VISCOMETERTVB-10), No. The values measured after 3 minutes at 6 rotors and 20 revolutions were all 40 Pa · s or less.

(1) Preparation of test dentifrice composition Preparation of dentifrice composition involves dissolving a water-soluble substance such as saccharin sodium and sorbit in purified water, and then dissolving a cationic bactericidal agent such as cetylpyridinium chloride, and xanthan gum. A propylene glycol solution in which the binder was dispersed was added, and titanium oxide was added and stirred. Then, the fragrance | flavor, the abrasive | polishing agent, and the sodium lauryl sulfate were added in order, and also it stirred under reduced pressure (4 kPa), and obtained the dentifrice composition. In addition, the unimixer (FM-SR-25, POWEX CORPORATION) was used for manufacture.

  For preparation of these dentifrice compositions, titanium oxide (TIPAQUE manufactured by Ishihara Sangyo Co., Ltd.), cetylpyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.), benzalkonium chloride (manufactured by Wako Pure Chemical Industries, Ltd.) ), Benzethonium chloride (manufactured by Wako Pure Chemical Industries, Ltd.), stearyldimethylbenzylammonium chloride (manufactured by Wako Pure Chemical Industries, Ltd.), lauryltrimethylammonium chloride (manufactured by Wako Pure Chemical Industries, Ltd.), cetyltrimethylammonium chloride (Wako Pure Chemical Industries, Ltd.) was used. In addition, sodium fluoride, sorbit, sodium saccharin, silicic acid anhydride, xanthan gum, sodium polyacrylate, propylene glycol, sodium lauryl sulfate, methyl paraoxybenzoate, butyl paraoxybenzoate, and water use quasi-drug raw material standard products It was. About sorbit, the dentifrice composition was prepared using the 70% aqueous solution goods, and the compounding quantity of 70% aqueous solution was shown in the table | surface.

The abbreviations and names in the layer structure of the laminated tube used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: Low density polyethylene white LDPE: White low density polyethylene LLDPE: Linear low density polyethylene AL: Aluminum EAA: Copolymer resin of ethylene / acrylic acid PET: Polyethylene terephthalate EMAA: Copolymer resin of ethylene / methacrylic acid SiOx -PET: Glass-deposited polyethylene terephthalate

(2) Evaluation method of antiseptic power of dentifrice preparation Inoculate a test strain (bacteria and fungi derived from the environment) into 30 g of a dentifrice composition so as to be about 10 ⁷ CFU / g. The number of bacteria after 14 and 28 days was measured and evaluated according to the following criteria.

Evaluation criteria ◎: Bacteria die within 4 days ○: Bacteria die within 5-14 days Δ: Bacteria die within 15-28 days ×: Bacteria do not die

(3) Evaluation method of tastelessness in use It evaluated by the sensory test using ten expert panelists. About 1 g of the dentifrice was put on a commercial toothbrush and brushed for 3 minutes. The taste felt during use was evaluated based on the following four levels of comparison with the control product (the dentifrice of Comparative Example 6). The average score of the names was obtained and judged according to the following criteria.

Evaluation criteria for tastelessness in use (control product: Comparative Example 6)
4: There was no off-flavor compared to the control product. 3: There was almost no off-taste compared to the control product. 2: There was an equivalent taste compared to the control product. There was a nasty taste compared to the nasty taste of the control product
Judgment criteria for tastelessness during use (feeling of use) ◎: 3.5 points to 4.0 points ○: 3.0 points to less than 3.5 points △: 2.0 points to 3.0 points Less than points ×: Less than 2.0 points

  From the results of Tables 1 and 2, it was confirmed that the dentifrice composition (Example) of the present invention has high antiseptic power of the dentifrice preparation, almost no nasty taste during use, and excellent usability.

Claims (2)

  A dentifrice comprising a dentifrice composition having a moisture content of 45 to 70 mass% and a titanium oxide and a cationic bactericidal agent, wherein the titanium oxide content is 0.7 to 2 mass%. Composition.   The dentifrice composition according to claim 1, wherein the cationic bactericidal agent is at least one selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride.