JP5597970B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition that is excellent in biofilm bactericidal activity and hypersensitivity-suppressing action, has no disgusting taste, and is excellent in use feeling.

  Dentine hypersensitivity is a disease that causes pain when the gingiva is exposed due to the progression of periodontal disease or the like, and dentin is exposed, and stimulation such as abrasion or cold objects is transmitted to the nerve through the dentinal tubules. Therefore, in order to prevent or suppress dentin hypersensitivity, both the effects of sterilization of the oral biofilm that is the cause of periodontal disease and the relief of pain due to the obstructive action of nerve blunting and dentinal tubule sealing The composition for oral cavity having both of these is very effective.

  The sterilization of the oral biofilm is for various bacteria in the oral biofilm, which are considered to be the cause of the two major oral diseases of caries and periodontal disease. Oral bacteria related to oral diseases include Streptococcus mutans (S. mutans) and other obligate anaerobic species (p. Gingivalis) and periodontal disease. Examples include bacteria mainly gram-negative bacilli and oral bacteria such as F. nucleatum related to the cause of bad breath. It is said that it is useful to keep the number of pathogenic bacteria in the oral biofilm at a low level as an effective means for preventing and improving oral diseases.

  In order to reduce the number of pathogenic bacteria in the oral cavity, it is effective to use sparingly water-soluble bactericides, cationic bactericides, and anionic bactericides, especially for bacteria in biofilms. It has been proposed that high isopropylmethylphenol exerts an inhibitory effect on oral biofilms (Patent Document 1: Japanese Patent Laid-Open No. 2006-182626, Patent Document 2: Japanese Patent Laid-Open No. 2006-124315, Patent Document 3: JP 2005-179266 A, Patent Document 4: JP 2006-69909 A).

  On the other hand, as a preventive measure for dentin hypersensitivity, potassium nitrate, aluminum lactate, strontium chloride, etc., which are known as active ingredients for preventing hypersensitivity, are blended in oral compositions, which have a dull nerve action and a dentinal tubule blocking action. Techniques for relieving pain have been proposed. For example, Patent Document 5 (US Pat. No. 3,863,006) discloses that a dentifrice containing a potassium salt such as potassium nitrate reduces tooth sensitivity after brushing for several weeks. -48926) proposes a treatment method for applying potassium nitrate to gingiva and periodontal ligament tissue. Patent Document 7 (JP-A-5-155745) discloses that an oral composition containing an aluminum salt such as aluminum lactate suppresses hypersensitivity to dentin, and Patent Document 8 (JP-A 2001-172146). Japanese Laid-Open Patent Publication (Kokai) proposes an oral composition that contains a specific concentration of potassium nitrate and an aluminum salt such as aluminum lactate, is excellent in preventing and treating dentin hypersensitivity, and has a good feeling in use. An oral composition containing strontium chloride is proposed in Patent Document 9 (U.S. Pat. No. 3,212,483).

  If a poorly water-soluble bactericidal component such as isopropylmethylphenol and a hypersensitivity alleviating component such as isopropylmethylphenol are added to the dentifrice composition, it is considered that the bactericidal effect of the periodontal biofilm and the dentin hypersensitivity alleviating action can be combined. However, the combination of isopropylmethylphenol and a component that reduces hypersensitivity such as potassium nitrate, aluminum lactate, and strontium chloride causes a particular taste nuisance. It is desirable to improve this point.

  For the problem of unpleasant taste derived from isopropylmethylphenol, for example, a technique for reducing the taste of antibacterial components by blending a specific acyl sarcosine salt in combination with phenoxyethanol at a specific blending ratio (Patent Document 10: Japanese Patent Laid-Open 2007-161613), a technique for reducing off-flavors and tastes by blending l-menthol and sodium chloride at a specific mass ratio with respect to isopropylmethylphenol (Patent Document 11: Japanese Patent Laid-Open No. 2008-143825). Are known. However, when a large amount of acyl sarcosine salt is added, oral mucosal irritation considered to be derived from the acyl sarcosine salt occurs, and when sodium chloride is added, the flavor type may be limited depending on the salty taste. There was a problem.

In addition, for the problem of unpleasant taste derived from potassium nitrate, a technology that improves the bitterness, astringency, astringency, and discomfort by blending water-soluble polyphosphoric acid at a specific ratio with respect to potassium nitrate and polyhydric alcohol (Patent Document 12: Japanese Patent Laid-Open No. 2006-96696) and a technique for masking bitterness by blending a specific organic compound, a plant extract and baking soda (Patent Document 13: Japanese Patent Laid-Open No. 2002-302450) have been proposed. However, when blended with water-soluble polyphosphoric acid, there may be an unpleasant taste derived from water-soluble polyphosphoric acid, and when blended with a plant extract or baking soda, a new problem such as an unpleasant taste derived from both occurs. Has occurred.
With respect to the problem of unpleasant taste derived from aluminum lactate, a technique (Patent Document 14: Japanese Patent Laid-Open No. 2002-302429) that reduces bitterness and puffiness by adding baking soda to a non-aqueous preparation has been proposed. In the case of an aqueous preparation, potassium nitrate is not sufficient to suppress the hypersensitivity.

There is also a method of reducing taste by masking with a sweetener such as saccharin, but in this case, it is not always possible to suppress taste by excessively enhancing the taste of the sweetener.
Note that Patent Document 8 is a technique for improving astringency derived from potassium nitrate and aluminum lactate, and this technique cannot satisfactorily reduce the special taste that is derived from isopropylmethylphenol and an ingredient for suppressing hypersensitivity.

Moreover, when a fragrance | flavor was mix | blended in order to mask the unpleasant taste derived from isopropylmethylphenol or a hypersensitivity suppression component, the unpleasant taste in the fragrance | flavor itself might be felt during use.
For example, Patent Document 11 has been proposed as a technique of blending isopropylmethylphenol and a fragrance component. As a technique for improving the bitter taste of potassium nitrate with a fragrance component, a technique in which anethole and cineol, vanillin, citronellal and cinnamaldehyde are blended (Patent Document 15: JP-A-2003-73282) has been proposed. In addition, the composition which mix | blended isopropylmethylphenol and anisaldehyde is Examples 1-13 of patent document 1, Examples 1-3 of patent document 4, 6-12, 15-20, patent document 16 (international publication) No. 2007/69447 (Pamphlet) and Examples 11 to 17, 20, 21, and 23 of Patent Document 17 (Japanese Patent Laid-Open No. 2005-179266).
However, none of the techniques has been able to sufficiently improve the unique taste at the time of use derived from isopropylmethylphenol and the hypersensitivity-inhibiting component.

  Accordingly, there is a need for a new technique that is excellent in biofilm sterilization power and hypersensitivity mitigation action, and that can effectively reduce the unpleasant taste derived from the blended components and provide a dentifrice composition with excellent usability.

JP 2006-182661 A JP 2006-124315 A JP 2005-179266 A JP 2006-69909 A US Pat. No. 3,863,006 JP 60-48926 A JP-A-5-155745 JP 2001-172146 A U.S. Pat. No. 3,224,483 JP 2007-161613 A JP 2008-143825 A JP 2006-96696 A JP 2002-302450 A JP 2002-302429 A JP 2003-73282 A International Publication No. 2007/69447 Pamphlet JP 2005-179266 A

  This invention is made | formed in view of the said situation, and it aims at providing the dentifrice composition which was excellent in the biofilm bactericidal power and the hypersensitivity alleviation effect, and was excellent in the usability | use_condition without taste.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) isopropylmethylphenol, (B) one or more selected from potassium nitrate, aluminum lactate, and strontium chloride, (C) 3- By blending one or more fragrance components selected from octanol, 3-octyl acetate, 3-octanone, and Fencon, (D) anionic surfactant and / or nonionic surfactant , (E) anisaldehyde , surprisingly, excellent biofilm germicidal and hypersensitivity relieving action, and then found that toothpaste composition excellent in sense of use without sarcasm is obtained, leading to completion of the present invention.

  That is, in the present invention, by combining isopropylmethylphenol and a specific hypersensitivity inhibitor component into a dentifrice composition containing an anionic surfactant and / or a nonionic surfactant, excellent biofilm bactericidal power In addition to the above-mentioned effects, a combination of a specific perfume ingredient and the above-mentioned effects are combined with the above-mentioned effects to effectively reduce the taste of taste caused by the combined use of isopropylmethylphenol and a hypersensitivity-inhibiting ingredient. It also has an excellent feeling of use without masking.

  In addition, since the fragrance | flavor component of the said (C) component has characteristic fragrance | flavor and is used for a preparation flavor, such as cheese, a trace amount, since it is an unpleasant fragrance itself, dentifrice composition The use of things as perfumes was limited. When the present inventors use such a specific fragrance of the component (C) in combination with isopropylmethylphenol and a specific hypersensitivity-suppressing component, surprisingly, the specific flavor derived from isopropylmethylphenol and the specific hypersensitivity-suppressing component is unique. Dentifrice, i.e., the bitter taste derived from isopropylmethylphenol and the unique taste caused by astringency derived from the hypersensitivity-inhibiting ingredient can be effectively suppressed, and the taste taste derived from the blended flavor is not felt, and the dentifrice composition It has been found that a good feeling of use can be obtained, which is difficult to achieve with the fragrances generally used until now.

In this invention, the biofilm bactericidal power and the suppression effect of an unpleasant taste can be heightened more because mass ratio of (B) component / (A) component is 2-700.
Further, in the present invention, by adding (E) anisaldehyde to the dentifrice composition containing the components (A) to (D), the taste can be further reduced and the usability can be further improved.

Accordingly, the present invention provides a toothpaste composition below.
Claim 1:
(A) 0.01-0.2% by mass of isopropylmethylphenol,
(B) 0.1 to 15% by mass of one or more selected from potassium nitrate, aluminum lactate and strontium chloride
(C) 0.001 to 0.1% by mass of one or more perfume ingredients selected from 3-octanol, 3-octyl acetate, 3-octanone, and Fencon
(D) 0.1 to 5% by mass of an anionic surfactant and / or a nonionic surfactant ,
(E) Ri greens contain anisaldehyde 0.0001 wt%, pyridinedicarboxylic acid or toothpaste composition characterized by containing no salts thereof.
Claim 2:
The anionic surfactant as the component (D) is an alkyl sulfate, and the nonionic surfactant has an average addition mole number of polyoxyethylene hydrogenated castor oil or ethylene oxide having an average addition mole number of ethylene oxide of 10 to 20 mol. The toothpaste composition according to claim 1, which is ˜40 mol of polyoxyethylene alkyl ether.
Claim 3 :
Component (B) / (A) weight ratio of component according to claim 1 or 2 toothpaste composition according Ru der 2-700.

  The dentifrice composition of the present invention is excellent in biofilm bactericidal activity and hypersensitivity alleviation, has no disgusting and excellent in feeling of use, and is effective in preventing or treating dentin hypersensitivity.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention comprises (A) isopropylmethylphenol, (B) one or more selected from potassium nitrate, aluminum lactate and strontium chloride, (C) 3-octanol, 3-octyl acetate, 3- It contains one or two or more fragrance components selected from octanone and fenkon, (D) an anionic surfactant and / or a nonionic surfactant.

  (A) Isopropylmethylphenol used in the present invention is 4-isopropyl-3-methylphenol, and commercially available products such as those sold by Osaka Kasei Co., Ltd. can be used.

  (A) The blending amount of isopropylmethylphenol is preferably 0.01 to 0.2% (mass%, the same applies hereinafter), particularly 0.02 to 0.1% of the whole composition, and less than 0.01%. In some cases, a sufficient bactericidal effect may not be exhibited, and if it exceeds 0.2%, the taste detriment derived from isopropylmethylphenol may become strong and the taste may deteriorate.

  The components (B), potassium nitrate, aluminum lactate and strontium chloride, are blended as active ingredients for preventing or treating dentine hypersensitivity, and in particular, potassium nitrate and aluminum lactate from the viewpoint of inhibitory action on hypersensitivity. Can be preferably used. For these components (B), commercially available products can be used. For example, potassium nitrate is sold by Matsumoto Kosho, aluminum lactate is commercially available from Musashino Chemicals, and strontium chloride salt is genuine. Examples include strontium chloride hexahydrate commercially available from Chemical Co., Ltd.

  Although the said (B) component may mix | blend 1 type independently, it is desirable to use 2 or 3 types together, for example, using potassium nitrate and aluminum lactate, combining potassium nitrate and strontium chloride, especially potassium nitrate and Use in combination with aluminum lactate is preferred.

  The blending amount of the component (B) is preferably from 0.1 to 15%, particularly preferably from 0.5 to 10% of the whole composition. If it exceeds 50%, the taste is so strong that it may be difficult to use.

  In addition, although the compounding quantity of each said hypersensitivity suppression component can be suitably adjusted within the range of the compounding quantity of the said (B) component, the compounding quantity of potassium nitrate is 0.1 to 15% of the whole composition, especially 1 to 1. 10% is preferable, and if it is less than 0.1%, the hypersensitivity mitigating action may not be exhibited, and further, an oil phase containing a poorly water-soluble component such as isopropylmethylphenol and a fragrance component and an aqueous phase are stably blended. There is a case where an unpleasant taste is increased due to a small influence of the inorganic salt on the state of emulsification and dispersion used in the preparation. If it exceeds 15%, the taste is so strong that it may be difficult to use.

  The compounding amount of aluminum lactate or strontium chloride is preferably 0.1 to 10%, particularly preferably 0.5 to 5% of the total composition, and if it is less than 0.1%, the hypersensitivity mitigating action may not be exhibited. Disgusting taste increases due to less influence of inorganic salts on the state of emulsification and dispersion used to stably mix oil and water phases containing poorly water-soluble ingredients such as isopropylmethylphenol and perfume ingredients. There is a case. If it exceeds 10%, the taste is so strong that it may be difficult to use.

  In the present invention, the blending ratio of component (B) / component (A) is preferably 1 to 1000, and particularly preferably 2 to 700, in terms of mass ratio. When (B) / (A) is less than 1, there may be a strong sense of taste derived from isopropylmethylphenol, and when it exceeds 1000, satisfactory biofilm sterilization power cannot be obtained, or taste due to component (B). May feel strong and inferior in use.

Component (C) is an effective perfume ingredients to mask the peculiar disagreeable derived from isopropyl methylphenol and the component (B), 3-octanol, 3-octyl acetate, 3-octanone, 1 selected from fenchone A seed or two or more perfume ingredients.
When combining 2 or more types of the said fragrance | flavor components, the combination of 3-octanol, 3-octyl acetate, and / or Fencon is suitable.
In addition, even if it is octanol, since 1-octanol common as a fragrance | flavor of a dentifrice composition cannot satisfactorily mask the dislike derived from the target isopropylmethylphenol and (B) component, the fragrance | flavor which concerns on this invention Not suitable as an ingredient.

  As the component (C), commercially available products can be used. For example, 3-octanol is a product of Shiono Perfume Co., Ltd., 3-octyl acetate and 3-octanone are products of Inoue Perfume Co., Ltd., and Fencon is a perfume. You can use products from Eiko Co., Ltd.

  The total amount of component (C) is not particularly limited, but is 0.0001 to 0.1%, particularly 0.0005 to 0.05%, especially 0.001 to 0.02%, based on the total amount of the composition. desirable. If the blending amount is less than 0.0001%, the unique taste that isopropylmethylphenol and the component (B) have cannot be masked, and the feeling of use may be inferior. It may be too strong and cause disgust.

  (D) component is an anionic surfactant and / or a nonionic surfactant, and can mix 1 type (s) or 2 or more types. In this case, the anionic surfactant or the nonionic surfactant may be blended alone (comprising only the anionic surfactant or only the nonionic surfactant), or the anionic surfactant and the nonionic surfactant are used in combination. However, the combined use of an anionic surfactant and a nonionic surfactant is preferred.

Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, acyl sarcosine salts such as sodium lauroyl sarcosine and sodium myristoyl sarcosine, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, lauryl sulfo Examples thereof include N-acyl glutamate such as sodium acetate and sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate, and the like. Among these, alkyl sulfates (especially sodium salts) are preferable from the viewpoints of biofilm bactericidal activity, solubilization / dispersibility of components (A) and (C), and suppression of taste.
Specific examples of the alkyl sulfate include NIKKOL SLS (manufactured by Nikko Chemicals Co., Ltd.) as sodium lauryl sulfate, Emar 10PT (manufactured by Kao Corporation), and TEXAPON OC- as those having a mixed alkyl group of lauryl and myristyl. Commercial products such as P (manufactured by Cognis Japan Ltd.) can be used.

  Nonionic surfactants include, for example, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, alkyl glucoside, laurin Acid decaglyceryl or the like is used. Among these, polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether are preferable from the viewpoint of biofilm bactericidal power, solubilization / dispersibility of components (A) and (C), and suppression of taste.

As the polyoxyethylene hydrogenated castor oil, those having an average added mole number of ethylene oxide of 10 to 30 moles, particularly 10 to 20 moles are preferable from the viewpoint of unpleasant taste during use. Is less than 10 mol, Ru Kotogaa emulsification can not be sufficiently suppressed slap in use becomes insufficient dentifrice composition.

As such polyoxyethylene hydrogenated castor oil, commercially available products can be used. For example, NIKKOL HCO-10 (polyoxyethylene (10) hydrogenated castor oil, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL HCO-20 ( Polyoxyethylene (20) hydrogenated castor oil, manufactured by Nikko Chemicals Co., Ltd., NIKKOL HCO-30 (polyoxyethylene (30) hydrogenated castor oil, manufactured by Nikko Chemicals Co., Ltd. ), and the like.

  As polyoxyethylene alkyl ethers, those having an average addition mole number of ethylene oxide of 3 to 40 moles, particularly 5 to 20 moles, and those having an alkyl group of 12 to 18, especially 16 to 18 are biofilm sterilizers. It is preferable from the viewpoints of strength, solubilization / dispersibility of components (A) and (C), and suppression of unpleasant taste. Specific examples include polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether and the like in which the average added mole number of ethylene oxide is in the above range.

As such polyoxyethylene alkyl ether, a commercially available product can be used. For example, as polyoxyethylene cetyl ether, EMALEX 103 (polyoxyethylene (3) cetyl ether, manufactured by Nippon Emulsion Co., Ltd.), EMALEX 105 ( As polyoxyethylene stearyl ether such as polyoxyethylene (5) cetyl ether, manufactured by Nippon Emulsion Co., Ltd., EMALEX 107 (polyoxyethylene (7) cetyl ether, manufactured by Nippon Emulsion Co., Ltd.), EMALEX 603 (polyoxyethylene) (3) Stearyl ether, manufactured by Nippon Emulsion Co., Ltd., EMALEX 605 (polyoxyethylene (5) stearyl ether, manufactured by Nippon Emulsion Co., Ltd.), EMALEX 606 (polyoxyethylene ( ) Stearyl ether, Nippon Emulsion Co., Ltd.), EMALEX608 (polyoxyethylene (8) stearyl ether, Nippon Emulsion Co., Ltd.), EMA L EX620 (polyoxyethylene (20) stearyl ether, manufactured by Nippon Emulsion Co. ), EMA L EX630 (polyoxyethylene (30) stearyl ether, manufactured by Nihon Emulsion Co., Ltd.), EMA L EX640 (polyoxyethylene (40) stearyl ether, manufactured by Nihon Emulsion Co., Ltd.), etc., polyoxyethylene lauryl ether EMA L EX705 (polyoxyethylene (5) lauryl ether, manufactured by Nippon Emulsion Co., Ltd.), EMA L EX710 (polyoxyethylene (10) lauryl ether, manufactured by Nippon Emulsion Co., Ltd.), EMA L EX720 (polyoxyethylene (20) lauryl ether, manufactured by Nippon Emulsion Co., Ltd.), EMA L EX730 (polyoxyethylene (30) lauryl ether, manufactured by Nippon Emulsion Co., Ltd.), and the like.

  Among these, combinations of anionic surfactants and nonionic surfactants include alkyl sulfates and polyoxyethylene hydrogenated castor oil and / or polyoxyethylene alkyl ethers, particularly alkyl sulfates and polyoxyethylene hardened. A combination with castor oil is preferred.

  (D) The compounding amount of the anionic surfactant and / or nonionic surfactant is preferably 0.1 to 5%, particularly preferably 0.2 to 3% of the entire composition. If the blending amount is less than 0.1%, the biofilm sterilizing power may be reduced.

  Furthermore, in this invention, it is preferable to mix | blend anisaldehyde as (E) component, and by adding anisaldehyde in addition to the fragrance | flavor component of (C) component, it is unique from isopropylmethylphenol and (B) component. The effect of masking the unpleasant taste can be further enhanced, and the flavor becomes better.

  As anisaldehyde, commercially available products such as products of Taiyo Perfume Co., Ltd. can be used. The blending amount is preferably 0.0001 to 0.1%, particularly 0.0005 to 0.05%, particularly 0.001 to 0.02%, based on the total amount of the composition. If the blending amount is less than 0.0001%, the masking effect of unpleasant taste derived from isopropylmethylphenol and the component (B) may not be sufficiently enhanced, and if it exceeds 0.1%, the smell of anisaldehyde itself may be If it is too strong, it may cause an unpleasant taste and give the user an unpleasant feeling.

(E) When anisaldehyde is blended, the total blending amount of the component (C) and the component (E) from the point of further improving the masking effect of unpleasant taste derived from isopropylmethylphenol and the component (B) and improving the flavor. Can be 0.0002 to 0.15%, particularly 0.002 to 0.03%. If the total blending amount is less than 0.0002%, the masking effect of disgusting may not be sufficiently enhanced, and if it exceeds 0.2%, the flavors of the components (C) and (E) themselves are too strong to cause discomfort. May occur.
In addition, as a combination of (C) component and (E) component, the combination of 3-octanol and anisaldehyde is especially preferable, and the especially excellent masking effect is exhibited with respect to unique unpleasant taste by this.

  The dentifrice composition of the present invention can be prepared and applied as a toothpaste, liquid dentifrice, etc., in particular, as a toothpaste, and other appropriate known ingredients in addition to the above ingredients depending on the dosage form. Can be blended. Examples of the optional component include a wetting agent, a binder, a fragrance, a surfactant, an active ingredient, an abrasive, a pH adjuster, an antiseptic, a sweetener, a coloring agent, and the like, and within a range that does not hinder the effects of the present invention. Can be blended. The composition of the present invention can be produced by mixing these components and water by an ordinary method.

  As the wetting agent, sugar alcohols such as sorbit, glycerin, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, reduced starch saccharified product, or one or more of polyhydric alcohols can be blended. . The amount of the humectant is preferably 10 to 70% in the case of a toothpaste and 20 to 90% in the case of a liquid dentifrice with respect to the entire composition.

  As binder, cellulose binder such as sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylethylcellulose, methylcellulose, xanthan gum, carrageenan, guar gum, sodium alginate, cationized cellulose, montmorillonite, gelatin And sodium polyacrylate, and the like, and one or more of them can be blended. A compounding quantity is 0.1 to 5% normally with respect to the composition whole quantity.

  In addition to component (C) and component (E), other perfumes such as eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, peppermint Oil, spearmint oil, peppermint oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, coconut oil, sweetie oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, celery Oil, bay oil, origanum oil, pine needle oil, neroli oil, lemongrass oil, rose oil, jasmine oil, patchouli oil, iris concrete, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchoulia absolute, ginger oreo Natural flavors such as gin, pepper oleoresin, capsicum oleoresin, pepper extract, and processing of these natural flavors (front reservoir cut, rear reservoir cut, fractional distillation, liquid extraction, essence, powdered flavor Perfume and limonene, pinene, butanol, isoamyl alcohol, n-hexenol, cis-3-hexenol, cis-6-nonenol, linalool, α-terpineol, menthol, benzyl alcohol, phenylethyl alcohol, anethole, Thymol, methylchavicol, eugenol, carvone, menthone, pregon, 1,8-cineole, yonon, caron, n-hexanal, trans-2-hexenal, citral, cinnamaldehyde, benzaldehyde, ethyl acetate, ethyl butyrate , Isoamyl acetate, hexyl acetate, ethyl 2-methylbutyrate, allyl hexanoate, allyl cyclohexane propionate, linalyl acetate, menthyl acetate, menthyl lactate, carbyl acetate, phenoxyethyl isobutyrate, methyl jasmonate, salicylic acid Methyl, ethyl salicylate, methyl cinnamate, methyl anthranilate, phenyl ethyl glycidate, ethyl lactate, vanillin, maltol, gamma and delta lactones having 4 to 12 carbon atoms, ambretlide, dimethyl sulfide, trimethylpyrazine, ethyl β- Methylthiopropionate, furaneol, ethylcyclopentenolone, cycloten, 2-methylbutyric acid, propionic acid, p-meth Cinnamic aldehyde, 3-l-menthoxypropane-1,2-diol, menthone glycerol acetal, spiranthol, monomenthyl succinate, linalool oxide, vanillyl butyl ether, isopulegol, and other single flavors, strawberry flavor, apple flavor, Melon Flavor, Banana Flavor, Peach Flavor, Raspberry Flavor, Pineapple Flavor, Grape Flavor, Tropical Fruit Flavor, Mango Flavor, Ume Flavor, Orange Flavor, Lemon Flavor, Grapefruit Flavor, Tea Flavor, Butter Flavor, Milk Flavor, etc. And ethyl alcohol, propylene glycol, triacetin, glycerin fatty acid ester Known perfume materials used in dentifrice compositions, such as perfume solvents such as tellurium, can be used in combination. Although the compounding quantity of these fragrance | flavor raw materials is not specifically limited, It is preferable to use 0.000001 to 1% in a composition. Moreover, as a fragrance | flavor for perfume using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a composition.

  As the surfactant, in addition to the anionic surfactant and the nonionic surfactant, an amphoteric surfactant may be blended. Examples of the amphoteric surfactant include lauryl dimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, and coconut oil fatty acid. Amidopropyl betaine or the like is used, but is not limited to the above. When the amphoteric surfactant is blended, the blending amount is usually 0.1 to 5%.

  Various active ingredients include (A) isopropylmethylphenol, (B) potassium nitrate, aluminum lactate, strontium chloride and other active ingredients such as fluorine compounds such as sodium fluoride, sodium monofluorophosphate and tin fluoride. , Enzymes such as dextranase and mutanase, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphate, tranexamic acid, epsilon-aminocaproic acid, allantochlorhydroxyaluminum, hinokitiol, sodium lauroylsarcosine, ascorbic acid, acetic acid dl-tocopherol, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphine Chelating phosphate compounds such as carbonate, copper compounds such as copper gluconate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethylene maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, chloride Examples thereof include cetylpyridinium, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, soft sugar beet extract, buckwheat extract, chamomile, clove, rosemary, hornon, safflower and the like. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

Examples of the abrasive include silica-based abrasives such as silica gel, aluminosilicate , zirconosilicate, dibasic calcium phosphate dihydrate , dibasic calcium phosphate anhydrate , tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate, calcium pyrophosphate, etc. Calcium phosphate abrasive, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zeolite, silica One kind or two or more kinds of zirconium acid, hydroxyapatite, fluoroapatite, calcium deficient apatite , synthetic resin-based abrasive and the like can be used. The blending amount is usually 0 to 50%, especially 5 to 40% with respect to the total amount of the toothpaste, and 0 to 30%, particularly 2 to 15% with respect to the total amount of the liquid dentifrice. It is.

  Examples of pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, pyrophosphoric acid, glycerophosphoric acid and carbonic acid, and potassium salts, sodium salts and ammonium salts thereof, ribonucleic acid and salts thereof. Furthermore, 1 type (s) or 2 or more types, such as sodium hydroxide, can be normally added in the range which does not prevent the effect of this invention.

  Examples of the preservative include paraoxybenzoates such as butylparaben, propylparaben, ethylparaben, and methylparaben, benzoates such as sodium benzoate, potassium sorbate, and the like.

Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin and the like.
Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, Red No. 105, and the like.
In addition, the compounding quantity of these components can be made into a normal quantity in the range which does not prevent the effect of this invention.

  As a container, the material in particular of the container to accommodate is not restrict | limited, Usually, the container used for a toothpaste composition and a liquid dentifrice composition can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% is mass% unless otherwise specified.

Examples and comparative examples
Dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by the following production method.
(Production method)
The preparation of the dentifrice composition was prepared by dissolving a water-soluble substance such as sodium saccharin, sodium monofluorophosphate, and sorbit solution in purified water, and then adding a liquid in which a binder was dispersed in propylene glycol and stirring. did. Thereafter, polyoxyethylene hydrogenated castor oil, heat-dissolved polyoxyethylene (5) stearyl ether, fragrance, abrasive, sodium alkyl sulfate, etc. are added, and further stirred under reduced pressure (pressure 4 KPa) to obtain a dentifrice composition. It was. A unimixer (FM-SR-25, POWEX CORPORATION) was used for the production.

These dentifrice compositions were prepared using isopropylmethylphenol (Osaka Kasei Co., Ltd.), potassium nitrate (Matsumoto Kosho Co., Ltd.), aluminum lactate (Musashino Chemicals Co., Ltd.), strontium chloride ( Junsei Chemical Co., Ltd.), 3-octanol (manufactured by Shiono Koryo Co., Ltd.), 3-octyl acetate and 3-octanone (manufactured by Inoue Kako Co., Ltd.), Fencon (manufactured by Koei Kogyo Co., Ltd.), Anisaldehyde (manufactured by Taiyo Perfume Co., Ltd.), 1-octanol (manufactured by Takasago International Corporation), sodium lauryl sulfate (manufactured by Nikko Chemicals Co., Ltd., NIKKOL SLS), polyoxyethylene (20) hydrogenated castor oil (Nikko) Chemicals Co., Ltd., NIKKOL HCO-20), polyoxyethylene (5) stearyl ether (Nippon Emulsion Co., Ltd., EMAL X605), silica (manufactured by Rhodia Nikka Co., Ltd., TIXOSIL 73), sorbit (manufactured by Towa Kasei Kogyo Co., Ltd., D-sorbitol solution (70% aqueous solution)), sodium carboxymethylcellulose (Daicel Chemical Industries, Ltd., CMC1250) In addition, sodium monofluorophosphate, propylene glycol, sodium saccharin, titanium oxide, and purified water were used in conformity with the quasi-drug raw material standard 2006.
For Sorbit, a dentifrice composition was prepared using a 70% aqueous solution product. As the fragrance, fragrance compositions A to I shown in Table 4 were prepared and blended using the flavor composition shown in Table 5.

The obtained dentifrice composition was coated with a 26 mm diameter laminate tube (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30, thickness 257 μm (Dainippon). (Printed) was filled with 50 g.
The abbreviations and names in the layer structure of the laminated tube used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: Low density polyethylene white LDPE: White low density polyethylene LLDPE: Linear low density polyethylene AL: Aluminum PET: Polyethylene terephthalate EMAA: Ethylene / methacrylic acid copolymer resin

  The obtained dentifrice composition was evaluated by the following methods for the biofilm bactericidal activity, the hypersensitivity suppressing effect, and the level of tastelessness. The results are shown in Tables 1-3.

(1) Evaluation method of model biofilm bactericidal effect Triptychase soy broth treated with human unstimulated saliva filtered through a 0.45 μm filter with a 7 mm diameter hydroxyapatite (HA) plate and added with hemin and menadione Among them, Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nuclatum, Fusobacterium nucleatum A model biofilm is formed on the HA plate by continuous culture for a week. Made. Once a day after culturing for 2 weeks, artificial saliva (50 mmol / L KCl + 1 mmol / L KH ₂ PO ₄ +1 mmol / L CaCl ₂ +0.1 mmol / L MgCl ₂ (pH 7.0)) is added to the dentifrice preparation shown in the following table. The centrifugal supernatant after adding and dispersing 2 times the mass was used as a test drug solution, and the model biofilm was immersed in the solution for 3 minutes and further cultured for 3 days. At the end of the culture, the model biofilm was taken out, dispersed, and cultured on an agar plate to determine the number of viable bacteria of each bacterial species in the model biofilm. Although the number of viable bacteria may fluctuate somewhat depending on the culture conditions, when artificial saliva is used instead of the test drug solution, it is about 8.5 log cfu (colony forming units / HA plate), and 6.0 log cfu / HA plate In the case of less than, it was judged that the biofilm sterilizing power was high. The evaluation criteria are shown below.
Evaluation criteria for model biofilm sterilization effect ◎: Less than 5.0 log cfu / HA plate ○: More than 5.0 log cfu / HA plate to less than 6.0 log cfu / HA plate Δ: More than 6.0 log cfu / HA plate to 7.0 log Less than cfu / HA plate x: 7.0 log cfu / HA plate or more

(2) Inhibition of hypersensitivity Test dentifrice composition filled in laminate tube after letting 10 panelists of hypersensitivity that teeth appear when cold water is contained in mouth for 4 weeks The product was extruded 1 cm onto a toothbrush, brushed for 2 minutes in the same manner as usual, and evaluated according to Evaluation Criteria-1 shown below. The average score of 10 people was evaluated by Evaluation Criteria-2.
Evaluation criteria-1
5 points: After brushing, if cold water is included in the mouth, teeth will not stain at all 4 points: After brushing, if cold water is included in the mouth, teeth will not stain 3 points: After brushing, if cold water is included in the mouth, most teeth No scrubbing, no problem level 2 points: After brushing, if you have cold water in your mouth, your teeth will rub 1 point: After brushing, if you have cold water in your mouth, Evaluation Criteria-2
◎: Average score of 10 people is 4.0 points or more ○: Average score of 10 people is 3.0 points or more and less than 4.0 points △: Average score of 10 people is 2.0 points or more and less than 3.0 points × : Average score of 10 people is less than 2.0

(3) Evaluation of tastelessness A sensory test was conducted using 10 expert panelists. About 1 g of the dentifrice composition was placed on a commercially available toothbrush and brushed for 3 minutes. The unpleasant taste felt during use was evaluated according to the following rating. An average value of the evaluation results of 10 people was obtained, and those for which evaluations of ◎ and ○ were ensured based on the following criteria were judged to be dentifrice compositions without taste.
(Score)
4 points: no disgusting 3 points: little disgusting 2 points: slightly disgusting 1 point: disgusting (evaluation criteria)
◎: 3.7 points to 4.0 points ◎ to ○: 3.3 points to less than 3.7 points ○: 3.0 points to less than 3.3 points Δ: 2.0 points to 3 points Less than 0 point x: Less than 2.0 point

From the results of Tables 1 to 3, if any of the components (A) to (D) is missing or if the blending amount of these components is inappropriate, the biofilm bactericidal power, the hypersensitivity suppressing action, and the tastelessness On the other hand, the dentifrice compositions (Examples) of the present invention are excellent in biofilm bactericidal activity and hypersensitivity suppressing action, have no disgusting, and have a good feeling of use. It turns out that it combines. In Reference Examples 1 to 35 and Examples 1 to 44 , the same results were obtained even when the fragrance composition A was replaced with any of the fragrance compositions B to I.

＊：上記香料組成中に３−オクタノール、３−オクチルアセテート、３−オクタノン、フ
ェンコン、アニスアルデヒドは含まれない。

*: The above fragrance composition does not contain 3-octanol, 3-octyl acetate, 3-octanone, phencon, or anisaldehyde.

Claims (3)

(A) 0.01-0.2% by mass of isopropylmethylphenol,
(B) 0.1 to 15% by mass of one or more selected from potassium nitrate, aluminum lactate and strontium chloride
(C) 0.001 to 0.1% by mass of one or more perfume ingredients selected from 3-octanol, 3-octyl acetate, 3-octanone, and Fencon
(D) 0.1 to 5% by mass of an anionic surfactant and / or a nonionic surfactant ,
(E) Ri greens contain anisaldehyde 0.0001 wt%, pyridinedicarboxylic acid or toothpaste composition characterized by containing no salts thereof. The anionic surfactant as the component (D) is an alkyl sulfate, and the nonionic surfactant has an average addition mole number of polyoxyethylene hydrogenated castor oil or ethylene oxide having an average addition mole number of ethylene oxide of 10 to 20 mol. The toothpaste composition according to claim 1, which is ˜40 mol of polyoxyethylene alkyl ether. Component (B) / (A) weight ratio of component according to claim 1 or 2 toothpaste composition according Ru der 2-700.