JP7031253B2 - Toothpaste composition - Google Patents

Toothpaste composition Download PDF

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JP7031253B2
JP7031253B2 JP2017228839A JP2017228839A JP7031253B2 JP 7031253 B2 JP7031253 B2 JP 7031253B2 JP 2017228839 A JP2017228839 A JP 2017228839A JP 2017228839 A JP2017228839 A JP 2017228839A JP 7031253 B2 JP7031253 B2 JP 7031253B2
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oil
dentifrice
antibacterial effect
oral
component
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JP2019099470A (en
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優子 青木
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Lion Corp
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Lion Corp
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Priority to PCT/JP2018/042281 priority patent/WO2019107168A1/en
Priority to CN201880051483.4A priority patent/CN111050747B/en
Priority to KR1020207006424A priority patent/KR102651630B1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Description

本発明は、口腔内細菌への抗菌効果が長時間に亘って持続し、う蝕や歯周病の予防又は抑制に好適な、イソプロピルメチルフェノール含有の歯磨剤組成物に関する。 The present invention relates to an isopropylmethylphenol-containing dentifrice composition, which has an antibacterial effect on oral bacteria for a long period of time and is suitable for prevention or suppression of dental caries and periodontal disease.

う蝕や歯周病等の口腔疾患の原因ともなる口腔内細菌を殺菌するため、殺菌剤や抗菌剤を配合した歯磨剤等の口腔用組成物を用いること、更には、好ましい予防策として就寝前に歯磨きを行うことが推奨されることは広く知られているが、口腔内の病原性細菌を完全に殺菌することは難しい。とりわけ就寝中の口腔内は、細菌が繁殖し易い温度や湿度に維持されているため、一晩で口腔内細菌数が激増する傾向にある。従って、例えば就寝前に歯磨きし、一晩睡眠後、起床時までも抗菌効果が持続すれば効果的であると考えられるが、従来の歯磨剤組成物による抗菌力は持続性に課題があり十分とは言い難く、長時間に亘って、例えば一晩睡眠して起床時までも持続する抗菌効果が得られる歯磨剤組成物が望まれていた。 In order to kill oral bacteria that cause oral diseases such as caries and periodontal disease, use an oral composition such as a dentifrice containing a bactericidal agent or an antibacterial agent, and go to bed as a preferable preventive measure. It is widely known that it is recommended to brush the teeth before, but it is difficult to completely kill the pathogenic bacteria in the oral cavity. In particular, the oral cavity during sleep is maintained at a temperature and humidity at which bacteria can easily grow, so that the number of bacteria in the oral cavity tends to increase dramatically overnight. Therefore, for example, it is considered effective if the dentifrice is brushed before going to bed and the antibacterial effect is maintained even after sleeping overnight and even when waking up. It is hard to say, and a dentifrice composition capable of obtaining an antibacterial effect that lasts for a long time, for example, sleeping overnight and even when waking up, has been desired.

口腔用の殺菌剤や抗菌剤による作用の改善技術は種々提案されている。例えば、非イオン性殺菌剤としてイソプロピルメチルフェノールにはバイオフィルム浸透殺菌作用があり、その殺菌力向上のために特定の香料成分とアニオン性界面活性剤のアシルタウリン塩又は特定の糖アルコール等とを配合した歯磨剤組成物が特許文献1、2(特開2011-98916号公報、特開2011-98918号公報)に提案されているが、殺菌力の持続性に関しては触れられておらず不明である。また、特許文献3(特許第5568876号公報)には、イソプロピルメチルフェノールとアラビトールとを併用した脱灰抑制剤が提案され、界面活性剤と共に洗口剤等の口腔用組成物に配合されることが開示されている。 Various techniques for improving the action of oral bactericides and antibacterial agents have been proposed. For example, as a non-ionic bactericidal agent, isopropylmethylphenol has a biofilm penetrating bactericidal action, and in order to improve its bactericidal activity, a specific fragrance component and an anionic surfactant acyltaurine salt, a specific sugar alcohol, or the like are used. The blended dentifrice composition has been proposed in Patent Documents 1 and 2 (Japanese Patent Laid-Open Nos. 2011-98916 and 2011-98918), but the sustainability of bactericidal activity is not mentioned and is unknown. be. Further, Patent Document 3 (Patent No. 5568876) proposes a demineralization inhibitor in which isopropylmethylphenol and arabitol are used in combination, and may be incorporated into an oral composition such as a mouthwash together with a surfactant. Is disclosed.

一方、口腔用組成物の配合成分として緑茶等のチャ抽出物が、使用感の改善のみならずその抗菌作用によってう蝕や口臭の予防に応用できることが、特許文献4~7(特開平11-222419号公報、特許第5067529号公報、特開2006-199661号公報、国際公開第2013/100089号)に開示されているが、抗菌効果の持続性について言及されていない。 On the other hand, it can be applied to the prevention of dental caries and bad breath due to its antibacterial action as well as the improvement of usability of tea extract such as green tea as a compounding component of the oral composition. It is disclosed in Japanese Patent No. 222419, Japanese Patent No. 5067529, Japanese Patent Application Laid-Open No. 2006-199661, International Publication No. 2013/100089), but does not mention the sustainability of the antibacterial effect.

特開2011-98916号公報Japanese Unexamined Patent Publication No. 2011-98916 特開2011-98918号公報Japanese Unexamined Patent Publication No. 2011-98918 特許第5568876号公報Japanese Patent No. 5568876 特開平11-222419号公報Japanese Unexamined Patent Publication No. 11-22419 特許第5067529号公報Japanese Patent No. 5067529 特開2006-199661号公報Japanese Unexamined Patent Publication No. 2006-199661 国際公開第2013/100089号International Publication No. 2013/100089

本発明は上記事情に鑑みなされたもので、口腔内細菌への抗菌効果が長時間に亘って持続する歯磨剤組成物を提供することを目的とする。 The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition in which an antibacterial effect against oral bacteria is maintained for a long period of time.

本発明者は、上記目的を達成するため鋭意検討を行った結果、口腔用殺菌剤のうちのイソプロピルメチルフェノールと、特定のアニオン性界面活性剤とチャエキスとを組み合わせて口腔用組成物、特に歯磨剤組成物に配合すると、抗菌効果の持続性が格段に向上し、歯磨き直後から長時間経過後も持続する抗菌効果を付与できること、また、刺激や嫌味が抑えられ使用感も良好になることを知見した。即ち、本発明によれば、(A)イソプロピルメチルフェノール、(B)α-オレフィンスルホン酸塩、及び(C)チャエキスを配合した歯磨剤組成物によって、口腔内細菌への抗菌効果が長時間に亘って持続し、また、低刺激で味もよい使用感も付与できることを見出し、本発明をなすに至った。 As a result of diligent studies to achieve the above object, the present inventor combined isopropylmethylphenol among oral disinfectants with a specific anionic surfactant and cha extract to make an oral composition, especially a dentifrice. When blended in the agent composition, the sustainability of the antibacterial effect is remarkably improved, the antibacterial effect that lasts for a long time immediately after brushing the teeth can be imparted, and the irritation and dislike are suppressed and the usability is improved. I found out. That is, according to the present invention, the dentifrice composition containing (A) isopropylmethylphenol, (B) α-olefin sulfonate, and (C) cha extract has a long-term antibacterial effect on oral bacteria. We have found that it can be sustained for a long time and can be given a mild and tasty feeling of use, and have led to the present invention.

更に詳述すると、口腔用の抗菌剤による抗菌効果の持続性は十分ではなく、チャエキスによる抗菌効果は弱く持続性も悪い。一方、歯磨剤組成物の汎用成分であるアニオン性界面活性剤等の界面活性剤は、一般的に洗浄作用を有し、ある程度の抗菌効果があることも知られているが、界面活性剤によって満足な抗菌効果を与えることはできないものであった。しかし、本発明では、(A)、(B)及び(C)成分と組み合わせると、意外にも、三者が相乗的に作用し、口腔内細菌、特に歯周病等の病原性細菌への抗菌効果の持続性が格段に向上し、歯磨き直後から長時間経過後においても持続する優れた抗菌効果を付与できた。また、(A)成分には独特な嫌味、(B)成分には独特な刺激や苦味もあるにもかかわらず、三者を組み合わせると、予想外に、これら成分が相互作用して前記の嫌味及び刺激を十分に抑制して良い使用感を与えることもできた。従って、本発明によれば、う蝕、歯周病等の口腔疾患の原因ともなる口腔内細菌を長時間に亘って持続的に抗菌し、効果的に予防又は抑制することが可能である。
本発明では、(A)、(B)及び(C)成分の組み合わせが、口腔用の抗菌剤として特異的かつ格別な作用効果を与えるものであり、かかる作用効果、とりわけ抗菌効果の持続性は、後述の比較例の結果からも明らかなように、(A)、(B)又は(C)成分のいずれかを欠くと劣るものであった(比較例2~5)。この場合、(A)成分が配合されていないと、抗菌剤であるトリクロサンと(B)及び(C)成分とが配合されていても抗菌効果の持続性(8時間後)が劣り(比較例3)、(B)成分が配合されていないと、(A)及び(C)成分が配合され、更にアニオン性界面活性剤のラウリル硫酸ナトリウムが配合されていても、抗菌効果の持続性(8時間後)が劣っていた(比較例4)。
More specifically, the antibacterial effect of the oral antibacterial agent is not sufficiently sustained, and the antibacterial effect of Cha Extract is weak and persistent. On the other hand, surfactants such as anionic surfactants, which are general-purpose components of dentifrice compositions, are generally known to have a cleaning action and a certain degree of antibacterial effect, but depending on the surfactant. It was not possible to give a satisfactory antibacterial effect. However, in the present invention, when combined with the components (A), (B) and (C), surprisingly, the three act synergistically to deal with oral bacteria, especially pathogenic bacteria such as periodontal disease. The sustainability of the antibacterial effect was remarkably improved, and an excellent antibacterial effect that lasted for a long time immediately after brushing the teeth could be imparted. In addition, although the component (A) has a unique sarcasm and the component (B) has a unique stimulus and bitterness, when the three are combined, these components unexpectedly interact with each other to achieve the above-mentioned sarcasm. It was also possible to sufficiently suppress irritation and give a good feeling of use. Therefore, according to the present invention, it is possible to continuously antibacterialize oral bacteria that cause oral diseases such as dental caries and periodontal disease for a long period of time, and effectively prevent or suppress them.
In the present invention, the combination of the components (A), (B) and (C) gives a specific and special action and effect as an antibacterial agent for the oral cavity, and the action and effect, particularly the sustainability of the antibacterial effect, is As is clear from the results of the comparative examples described later, the lack of any of the components (A), (B) or (C) was inferior (Comparative Examples 2 to 5). In this case, if the component (A) is not blended, the durability of the antibacterial effect (after 8 hours) is inferior even if the antibacterial agents triclosan and the components (B) and (C) are blended (Comparative Example). 3) If the components (B) are not blended, the components (A) and (C) are blended, and even if the anionic surfactant sodium lauryl sulfate is blended, the antibacterial effect is sustained (8). After hours) was inferior (Comparative Example 4).

従って、本発明は、下記の歯磨剤組成物を提供する。
〔1〕
(A)イソプロピルメチルフェノール、
(B)α-オレフィンスルホン酸塩
及び
(C)チャエキス
を含有することを特徴とする歯磨剤組成物。
〔2〕
(A)成分を0.001~0.1質量%、(B)成分を0.1~2質量%、(C)成分をエキス純分として0.0007~0.01質量%含有する〔1〕に記載の歯磨剤組成物。
〔3〕
練歯磨剤である〔1〕又は〔2〕に記載の歯磨剤組成物。
Therefore, the present invention provides the following dentifrice composition.
[1]
(A) Isopropylmethylphenol,
A dentifrice composition comprising (B) α-olefin sulfonate and (C) cha extract.
[2]
It contains 0.001 to 0.1% by mass of the component (A), 0.1 to 2% by mass of the component (B), and 0.0007 to 0.01% by mass of the pure extract of the component (C) [1]. ] The dentifrice composition according to.
[3]
The dentifrice composition according to [1] or [2], which is a dentifrice.

本発明によれば、口腔内細菌への抗菌効果が長時間に亘って持続し、使用感も良い歯磨剤組成物を提供できる。本発明の歯磨剤組成物は、抗菌効果が使用後も持続することから、う蝕、歯周病等の口腔疾患の原因ともなる口腔内細菌の増加を長時間に亘って防止し、より効果的かつ有効にう蝕、歯周病等の口腔疾患を予防又は抑制することができる。 According to the present invention, it is possible to provide a dentifrice composition that has an antibacterial effect on oral bacteria for a long period of time and has a good usability. Since the antibacterial effect of the dentifrice composition of the present invention is maintained even after use, it is more effective by preventing the increase of oral bacteria that cause oral diseases such as dental caries and periodontal disease for a long period of time. It is possible to prevent or suppress oral diseases such as dental caries and periodontal disease in a targeted and effective manner.

以下、本発明につき更に詳述する。本発明の歯磨剤組成物は、(A)イソプロピルメチルフェノール、(B)α-オレフィンスルホン酸塩及び(C)チャエキスを含有する。 Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention contains (A) isopropylmethylphenol, (B) α-olefin sulfonate and (C) cha extract.

(A)イソプロピルメチルフェノールは、抗菌剤であり、その配合量は、組成物全体の0.001~0.1%(質量%、以下同様)が好ましく、より好ましくは0.01~0.06%である。配合量が0.001%以上であると十分な抗菌効果が発揮され、0.1%以下であるとそれ自身による独特な嫌味が十分に抑えられる。 (A) Isopropylmethylphenol is an antibacterial agent, and the blending amount thereof is preferably 0.001 to 0.1% (mass%, the same applies hereinafter) of the entire composition, and more preferably 0.01 to 0.06. %. When the blending amount is 0.001% or more, a sufficient antibacterial effect is exhibited, and when it is 0.1% or less, the peculiar sarcasm due to itself is sufficiently suppressed.

(B)α-オレフィンスルホン酸塩は、(C)チャエキスと併用することで、(A)成分の抗菌作用の持続性向上剤として作用し、また、(A)成分の嫌味の抑制剤としても作用する。
(B)α-オレフィンスルホン酸塩は、炭素数が10~16、特に14~16のα-オレフィンスルホン酸のナトリウム、カリウム等のアルカリ金属塩を用いることができる。好ましくは炭素数14のα-オレフィンスルホン酸塩、特にナトリウム塩(一般名;テトラデセンスルホン酸ナトリウム)である。
これらは、口腔用製剤に使用可能な市販品、例えばライオン・スペシャリティ・ケミカルズ(株)製の商品名「KリポランPJ-400CJ」を使用することができる。
When the (B) α-olefin sulfonate is used in combination with the (C) cha extract, it acts as an agent for improving the sustainability of the antibacterial action of the component (A) and also as an agent for suppressing the sarcasm of the component (A). It works.
(B) As the α-olefin sulfonic acid salt, an alkali metal salt such as sodium or potassium of the α-olefin sulfonic acid having 10 to 16 carbon atoms, particularly 14 to 16 carbon atoms can be used. An α-olefin sulfonate having 14 carbon atoms, particularly a sodium salt (generic name; sodium tetradecene sulfonate) is preferable.
For these, commercially available products that can be used for oral preparations, for example, trade name "K Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

(B)α-オレフィンスルホン酸塩の配合量は、組成物全体の0.1~2%が好ましく、より好ましくは0.3~1%である。配合量が0.1%以上であると、持続的な抗菌効果が十分に得られる。2%以下であると、それ自身による刺激や苦味を十分に抑制し低刺激性の使用感となる。 The blending amount of the α-olefin sulfonate (B) is preferably 0.1 to 2%, more preferably 0.3 to 1% of the total composition. When the blending amount is 0.1% or more, a long-lasting antibacterial effect can be sufficiently obtained. When it is 2% or less, irritation and bitterness due to itself are sufficiently suppressed, and a hypoallergenic feeling of use is obtained.

(C)チャエキスは、(B)成分と併用することで、(A)成分の抗菌作用の持続性向上剤として作用し、また、(A)成分の嫌味や(B)成分の刺激の抑制剤としても作用する。
チャエキスは、市販品又は公知の方法によって得られたものを使用できる。
具体的に原料は、緑茶を使用し得る。抽出溶媒は親水性溶媒が使用でき、水や、エタノール、プロパノール等の低級1価アルコール、1,3-ブチレングリコール、プロピレングリコール等の多価アルコールなどが挙げられ、これらから選ばれる1種の単独溶媒又は2種以上の混合溶媒を使用できる。抽出条件、後処理は通常の方法を採用できる。
市販品としては、緑茶抽出物(「和ism」、丸善製薬(株)製)等が挙げられる。
(C) Cha extract acts as a long-lasting agent for the antibacterial action of the component (A) when used in combination with the component (B), and also suppresses the sarcasm of the component (A) and the irritation of the component (B). Also works as.
As the cha extract, a commercially available product or a product obtained by a known method can be used.
Specifically, green tea can be used as the raw material. A hydrophilic solvent can be used as the extraction solvent, and examples thereof include water, lower monohydric alcohols such as ethanol and propanol, and polyhydric alcohols such as 1,3-butylene glycol and propylene glycol. A solvent or a mixed solvent of two or more kinds can be used. Normal methods can be used for extraction conditions and post-processing.
Examples of commercially available products include green tea extract (“Wa ism”, manufactured by Maruzen Pharmaceuticals Co., Ltd.) and the like.

(C)チャエキスの配合量は、溶媒を除いたエキス純分として、組成物全体の0.0007~0.01%が好ましく、より好ましくは0.001~0.005%である。配合量が0.0007%以上であると、持続的な抗菌効果が十分に得られ、0.01%以下であると、味(嫌味)の悪化を防止して使用感を良好に維持できる。 The blending amount of the cha extract (C) is preferably 0.0007 to 0.01%, more preferably 0.001 to 0.005%, as the pure extract content excluding the solvent. When the blending amount is 0.0007% or more, a long-lasting antibacterial effect can be sufficiently obtained, and when it is 0.01% or less, deterioration of taste (sarcasm) can be prevented and a good usability can be maintained.

なお、本発明において、(A)成分に対する(B)成分又は(C)成分の配合割合、あるいは(B)成分と(C)成分との配合割合は、特に限定されないが、それぞれ上記した各成分の配合量を満たす範囲内で設定することができる。 In the present invention, the blending ratio of the component (B) or the component (C) to the component (A), or the blending ratio of the component (B) and the component (C) is not particularly limited, but each of the above-mentioned components is not particularly limited. It can be set within a range that satisfies the blending amount of.

本発明の歯磨剤組成物は、練歯磨、液体歯磨等の液状歯磨、潤製歯磨などとして、通常の方法で調製することができ、特に練歯磨剤として好適である。また、上記成分に加えて、その他の公知成分を必要に応じて、本発明の効果を妨げない範囲で配合できる。例えば、練歯磨剤では研磨剤、湿潤剤、粘結剤、(B)成分以外の界面活性剤、更に必要により着色剤、甘味料、防腐剤、香料、(A)及び(C)成分以外の有効成分などを配合し得る。これらの配合量は、本発明の効果を妨げない範囲で通常量でよい。 The dentifrice composition of the present invention can be prepared by a usual method as a dentifrice, a liquid dentifrice such as a liquid dentifrice, a dentifrice, and the like, and is particularly suitable as a dentifrice. Further, in addition to the above-mentioned components, other known components can be blended, if necessary, within a range that does not interfere with the effects of the present invention. For example, in dentifrices, abrasives, wetting agents, binders, surfactants other than the component (B), and if necessary, coloring agents, sweeteners, preservatives, fragrances, components other than the components (A) and (C) It may contain active ingredients and the like. The blending amount of these may be a normal amount as long as the effect of the present invention is not impaired.

研磨剤としては、沈降性シリカ、アルミノシリケート、ジルコノシリケート等のシリカ系研磨剤、リン酸カルシウム系化合物、炭酸カルシウム、合成樹脂系研磨剤などが挙げられ、特にシリカ系研磨剤がよい。研磨剤の配合量は、通常、2~50%、特に10~30%である。 Examples of the abrasive include silica-based abrasives such as precipitate silica, aluminosilicate and zirconosilicate, calcium phosphate-based compounds, calcium carbonate, and synthetic resin-based abrasives, and silica-based abrasives are particularly preferable. The blending amount of the abrasive is usually 2 to 50%, particularly 10 to 30%.

湿潤剤としては、ソルビット、キシリット等の糖アルコール、グリセリン、プロピレングリコール、平均分子量160~400(医薬部外品原料規格2006記載の平均分子量)のポリエチレングリコール等の多価アルコールが挙げられる。湿潤剤の配合量は、通常、5~50%、特に10~30%である。 Examples of the wetting agent include sugar alcohols such as sorbitol and xylit, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol having an average molecular weight of 160 to 400 (average molecular weight described in the non-medicinal product raw material standard 2006). The blending amount of the wetting agent is usually 5 to 50%, particularly 10 to 30%.

粘結剤としては、有機又は無機粘結剤を配合できる。具体的には、カルボキシメチルセルロースナトリウム、メチルセルロース、ヒドロキシメチルセルロース等のセルロース誘導体、アルギン酸プロピレングリコール等のアルギン酸誘導体、キサンタンガム等のガム類、カラギーナン、ポリビニルアルコール、ポリアクリル酸ナトリウムなどの有機粘結剤、ゲル化性シリカ、ゲル化性アルミニウムシリカ等の増粘性シリカなどの無機粘結剤が挙げられる。
粘結剤の配合量は、通常、0.1~10%、特に0.1~5%である。なお、本発明では、有機粘結剤及び無機粘結剤の配合が好ましく、有機粘結剤の配合量は5%以下、特に3%以下がよく、無機粘結剤の配合量は5%以下、特に2%以下がよい。
As the binder, an organic or inorganic binder can be blended. Specifically, cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose and hydroxymethyl cellulose, arginic acid derivatives such as propylene glycol alginate, gums such as xanthan gum, organic binders such as carrageenan, polyvinyl alcohol and sodium polyacrylate, and gelation. Examples thereof include inorganic binders such as thickening silica such as sex silica and gelling aluminum silica.
The blending amount of the binder is usually 0.1 to 10%, particularly 0.1 to 5%. In the present invention, the blending of the organic binder and the inorganic binder is preferable, the blending amount of the organic binder is 5% or less, particularly 3% or less, and the blending amount of the inorganic binder is 5% or less. Especially, 2% or less is good.

界面活性剤としては、(B)成分以外のアニオン性界面活性剤、ノニオン性界面活性剤、カチオン性界面活性剤、両性界面活性剤を配合できる。
アニオン性界面活性剤は、ラウリル硫酸塩等のアルキル硫酸塩などが挙げられる。
ノニオン性界面活性剤は、ショ糖脂肪酸エステル等の糖脂肪酸エステル、糖アルコール脂肪酸エステル、ソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油等のポリオキシエチレン脂肪酸エステル、ポリオキシエチレン高級アルコールエーテル、脂肪酸アルカノールアミドなどが挙げられる。
カチオン性界面活性剤は、アルキルアンモニウム型、アルキルベンジルアンモニウム塩などが挙げられる。両性界面活性剤としては、アルキルベタイン、脂肪酸アミドプロピルベタイン等の酢酸ベタイン型、アルキルイミダゾリニウムベタイン等のベタイン型、イミダゾリン型、イミダゾリウムベタイン型などが挙げられる。
界面活性剤の配合量は、通常、0~10%、特に0.1~5%である。
なお、(B)成分以外のアニオン性界面活性剤、特にラウリル硫酸塩の好ましい配合量は1~5%、特に1~3%である。また、ノニオン性界面活性剤の好ましい配合量は0~2%である。
As the surfactant, an anionic surfactant other than the component (B), a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended.
Examples of the anionic surfactant include alkyl sulfates such as lauryl sulfate.
Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and the like. Examples thereof include polyoxyethylene fatty acid ester, polyoxyethylene higher alcohol ether, and fatty acid alkanolamide.
Examples of the cationic surfactant include an alkylammonium type and an alkylbenzylammonium salt. Examples of the amphoteric tenside include an acetate betaine type such as alkyl betaine and fatty acid amide propyl betaine, a betaine type such as alkyl imidazolinium betaine, an imidazoline type, and an imidazolium betaine type.
The blending amount of the surfactant is usually 0 to 10%, particularly 0.1 to 5%.
The preferable blending amount of the anionic surfactant other than the component (B), particularly lauryl sulfate, is 1 to 5%, particularly 1 to 3%. The preferable blending amount of the nonionic surfactant is 0 to 2%.

着色剤としては、青色1号、黄色4号、二酸化チタン等が挙げられる。甘味料としては、サッカリンナトリウム等が挙げられる。
防腐剤としては、メチルパラベン、ブチルパラベン等のパラオキシ安息香酸エステル、安息香酸又はその塩等が挙げられる。
Examples of the colorant include Blue No. 1, Yellow No. 4, Titanium Dioxide and the like. Examples of the sweetener include saccharin sodium and the like.
Examples of the preservative include paraoxybenzoic acid esters such as methylparaben and butylparaben, benzoic acid or salts thereof and the like.

香料としては、ペパーミント油、スペアミント油、アニス油、ユーカリ油、ウィンターグリーン油、カシア油、クローブ油、タイム油、セージ油、レモン油、オレンジ油、ハッカ油、カルダモン油、コリアンダー油、マンダリン油、ライム油、ラベンダー油、ローズマリー油、ローレル油、カモミル油、キャラウェイ油、マジョラム油、ベイ油、レモングラス油、オリガナム油、パインニードル油、ネロリ油、ローズ油、ジャスミン油、グレープフルーツ油、スウィーティー油、柚油、イリスコンクリート、アブソリュートペパーミント、アブソリュートローズ、オレンジフラワー等の天然香料や、これら天然香料の加工処理(前溜部カット、後溜部カット、分留、液抽出、エッセンス化、粉末香料化等)した香料、及び、メントール、カルボン、アネトール、シネオール、サリチル酸メチル、シンナミックアルデヒド、オイゲノール、3-l-メントキシプロパン-1,2-ジオール、チモール、リナロール、リナリールアセテート、リモネン、メントン、メンチルアセテート、N-置換-パラメンタン-3-カルボキサミド、ピネン、オクチルアルデヒド、シトラール、プレゴン、カルビールアセテート、アニスアルデヒド、エチルアセテート、エチルブチレート、アリルシクロヘキサンプロピオネート、メチルアンスラニレート、エチルメチルフェニルグリシデート、バニリン、ウンデカラクトン、ヘキサナール、ブタノール、イソアミルアルコール、ヘキセノール、ジメチルサルファイド、シクロテン、フルフラール、トリメチルピラジン、エチルラクテート、エチルチオアセテート等の単品香料、更に、ストロベリーフレーバー、アップルフレーバー、バナナフレーバー、パイナップルフレーバー、グレープフレーバー、マンゴーフレーバー、バターフレーバー、ミルクフレーバー、フルーツミックスフレーバー、トロピカルフルーツフレーバー等の調合香料等、歯磨剤組成物に用いられる公知の香料素材を組み合わせて使用することができ、実施例記載の香料に限定されない。
香料の配合量は特に限定されないが、上記の香料素材は、組成物中に0.000001~1%使用するのが好ましく、上記香料素材を使用した賦香用香料は、組成物中に0.1~2%使用するのが好ましい。
Fragrances include peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, distilling, liquid extraction, essence, powder fragrance) Perfume, menthol, carboxylic, anator, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, timole, linalol, linalyl acetate, limonene, menton , Menthylacetate, N-substituted-paramentan-3-carboxamide, pinen, octylaldehyde, citral, pregon, calbea acetate, anisaldehyde, ethylacetate, ethylbutyrate, allylcyclohexanepropionate, methylanthranilate, ethylmethyl Single flavors such as phenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, ethylthioacetate, as well as strawberry flavor, apple flavor, banana flavor. , Peppermint flavor, Grape flavor, Mango flavor, Butter flavor, Milk flavor, Fruit mix flavor, Tropical fruit flavor, etc., can be used in combination with known fragrance materials used in dentifrice compositions. It is not limited to the fragrances described in the examples.
The blending amount of the fragrance is not particularly limited, but it is preferable to use 0.000001 to 1% of the above fragrance material in the composition, and the fragrance for fragrance using the above fragrance material is 0. It is preferable to use 1 to 2%.

有効成分としては、口腔用の薬効成分として公知のもの、例えば塩化セチルピリジニウム等のカチオン性殺菌剤、トラネキサム酸、アラントイン等の抗炎症剤、フッ化ナトリウム、モノフルオロリン酸ナトリウム等のフッ素含有化合物、酵素、植物抽出物、歯石防止剤、歯垢防止剤などが挙げられる。これらは、有効量配合できる。 The active ingredient is known as a medicinal ingredient for the oral cavity, for example, a cationic bactericidal agent such as cetylpyridinium chloride, an anti-inflammatory agent such as tranexamic acid and allantin, and a fluorine-containing compound such as sodium fluoride and sodium monofluorophosphate. , Enzymes, plant extracts, anti-dental agents, anti-plaque agents and the like. These can be blended in an effective amount.

以下、実施例及び比較例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。下記において%は特に断らない限りいずれも質量%を示す。 Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following,% indicates mass% unless otherwise specified.

[実施例、比較例]
表1~3に示す組成の歯磨剤組成物(練歯磨)を常法によって調製し、下記方法で評価した。結果を表に併記した。
[Examples, comparative examples]
Toothpaste compositions (dentifrices) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following method. The results are also shown in the table.

(1)適用直後の抗菌効果及び抗菌効果の持続性(8時間後)の評価方法-1
(1-1)モデルバイオフィルムの調製
直径7mm×厚さ3.5mmのハイドロキシアパタイト(HA)板(旭光学工業(株)製)を0.45μmのフィルターでろ過したヒト無刺激唾液で4時間処理したものをモデルバイオフィルム作製担体に用いた。培養液は、トリプチケースソイブロス(Difco社製)30gを1Lの精製水に溶解した液にヘミン(Sigma社製)5mg/L、ビタミンK(和光純薬工業(株)製)1mg/Lを添加したものを用いた。
口腔内細菌としては、ストレプトコッカス・ミュータンス ATCC25175株、ストレプトコッカス・サングイニス ATCC10556株、アクチノマイセス・ナエスランディー ATCC51655株、フゾバクテリウム・ヌクレアタム ATCC10953株及びベイヨネラ・パルブラ ATCC17745株を用い、これら5菌種をそれぞれ2×107cfu/mL(colony forming units)になるように上述の培養液に接種し、唾液処理したHA担体と共に37℃、嫌気条件下(80vol%窒素、10vol%二酸化炭素、10vol%水素)で2週間連続培養(培養液の置換率は10vol%とした)を行い、HA担体表面に5菌種混合のモデルバイオフィルムを形成させた。
(1) Evaluation method of antibacterial effect immediately after application and persistence of antibacterial effect (after 8 hours)-1
(1-1) Preparation of model biofilm 4 hours with human non-irritating saliva obtained by filtering a hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) having a diameter of 7 mm and a thickness of 3.5 mm with a 0.45 μm filter. The treated product was used as a model biofilm preparation carrier. The culture solution is 5 mg / L of hemin (manufactured by Sigma) and 1 mg / L of vitamin K (manufactured by Wako Pure Chemical Industries, Ltd.) in a solution prepared by dissolving 30 g of trypticase soybros (manufactured by Difco) in 1 L of purified water. Was added.
As the oral bacteria, Streptococcus mutans ATCC25175 strain, Streptococcus sanguinis ATCC10556 strain, Actinomyces naeslandy ATCC51655 strain, Fuzobacterium nucleotam ATCC10953 strain, and Bayonera palbra ATCC1745 strains were used, respectively, and 5 strains thereof were used. Inoculate the above-mentioned culture solution to 10 7 cfu / mL (colony forming units), and together with a saliva-treated HA carrier at 37 ° C. under anaerobic conditions (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) 2 Continuous culture was carried out for a week (the replacement rate of the culture solution was 10 vol%), and a model biofilm containing 5 bacterial species was formed on the surface of the HA carrier.

(1-2)適用直後の抗菌効果の評価方法
形成させた上記モデルバイオフィルムを、評価薬剤(評価する歯磨剤組成物に人工唾液*を2倍質量添加し、分散させた後、遠心した上清)2mLに3分間浸漬し、滅菌生理食塩水1mLで6回洗浄した。その後、滅菌生理食塩水4mL中で超音波処理(200μA、10秒間)することにより、滅菌生理食塩水中にモデルバイオフィルムを分散し、バクテロイデス寒天平板に50μL塗沫し、肉眼でコロニーが確認できるまで嫌気培養(80vol%窒素、10vol%二酸化炭素、10vol%水素)した。生育したコロニー数をカウントし、残存す生菌数(cfu)を求め、下記基準に則り、判定した。
*;人工唾液組成(溶媒;水、pH6.5)
CaCl2 2.2mmol/L
KH2PO4 2.2mmol/L
酢酸 0.1mol/L
Clostridium histolyticum由来のコラゲナーゼ
(Type 1A,Sigma社製) 1.0単位/mL
<評価基準>
◎:cfuが106未満
○:cfuが106以上107未満
×:cfuが107以上
(1-2) Evaluation method of antibacterial effect immediately after application The formed model biofilm is centrifuged after adding twice the mass of artificial saliva * to the evaluation agent (toothpaste composition to be evaluated), dispersing it, and then centrifuging it. Qing) Soaked in 2 mL for 3 minutes and washed 6 times with 1 mL of sterile saline. Then, by sonication (200 μA, 10 seconds) in 4 mL of sterile saline, the model biofilm was dispersed in sterile saline, and 50 μL was smeared on a Bacteroides agar plate until colonies could be confirmed with the naked eye. Anaerobic culture (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) was performed. The number of grown colonies was counted, the number of remaining viable bacteria (cfu) was determined, and the determination was made according to the following criteria.
*; Artificial saliva composition (solvent; water, pH 6.5)
CaCl 2 2.2 mmol / L
KH 2 PO 4 2.2 mmol / L
Acetic acid 0.1 mol / L
Collagenase derived from Clostridium collagenase (Type 1A, manufactured by Sigma) 1.0 unit / mL
<Evaluation criteria>
⊚: cfu is less than 10 6 ○: cfu is 10 6 or more and less than 10 7 ×: cfu is 10 7 or more

(1-3)抗菌効果の持続性(8時間後)の評価方法
形成させた上記モデルバイオフィルムを、評価薬剤((1-2)と同様にして得た歯磨剤組成物上清)2mLに3分間浸漬し、滅菌生理食塩水1mLで6回洗浄した後、37℃で8時間嫌気培養した。培養後、滅菌生理食塩水4mL中で超音波処理(200μA、10秒間)することにより、滅菌生理食塩水中にモデルバイオフィルムを分散し、バクテロイデス寒天平板に50μL塗沫し、肉眼でコロニーが確認できるまで嫌気培養(80vol%窒素、10vol%二酸化炭素、10vol%水素)した。生育したコロニー数をカウントし、残存す生菌数(cfu)を求め、下記基準に則り、判定した。
<評価基準>
◎:cfuが107未満
○:cfuが107以上108未満
×:cfuが108以上
(1-3) Method for evaluating the persistence of antibacterial effect (after 8 hours) The formed model biofilm was added to 2 mL of the evaluation agent (toothpaste composition supernatant obtained in the same manner as in (1-2)). The cells were soaked for 3 minutes, washed 6 times with 1 mL of sterile physiological saline, and then anaerobically cultured at 37 ° C. for 8 hours. After culturing, the model biofilm is dispersed in sterile saline by ultrasonic treatment (200 μA, 10 seconds) in 4 mL of sterile saline, and 50 μL is smeared on a Bacteroides agar plate, and colonies can be confirmed with the naked eye. Up to anaerobic culture (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen). The number of grown colonies was counted, the number of remaining viable bacteria (cfu) was determined, and the determination was made according to the following criteria.
<Evaluation criteria>
⊚: cfu is less than 10 7 ○: cfu is 10 7 or more and less than 10 8 ×: cfu is 10 8 or more

(2)使用感(低刺激性)の評価方法
専門家パネラー10人を用いた官能試験により評価した。歯磨剤組成物を歯ブラシ上に1g載せ、普段と同じ方法で3分間ブラッシングを行い、使用中に感じた舌及び口腔粘膜への刺激について、以下の評点基準で判定した。
<評点基準>
4点:刺激が全くない
3点:刺激がほとんどない
2点:刺激がややある
1点:刺激がある
10人の評点結果を平均し、以下の評価基準で使用感(低刺激性)を評価した。◎及び○の評価が確保されるものを刺激のない歯磨剤組成物であると判断した。
<評価基準>
◎:3.5点以上4.0点以下
○:3.0点以上3.5点未満
△:2.0点以上3.0点未満
×:2.0点未満
(2) Evaluation method of usability (hypoallergenicity) Evaluation was made by a sensory test using 10 expert panelists. 1 g of the dentifrice composition was placed on a toothbrush and brushed for 3 minutes in the same manner as usual, and the irritation to the tongue and oral mucosa felt during use was judged according to the following score criteria.
<Score criteria>
4 points: No stimulus at all 3 points: Almost no stimulus 2 points: Slightly stimulating 1 point: Stimulated The score results of 10 people are averaged and the usability (hypoallergenicity) is evaluated according to the following evaluation criteria. did. It was judged that the dentifrice composition having no irritation was the one in which the evaluations of ⊚ and ○ were ensured.
<Evaluation criteria>
⊚: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: less than 2.0 points

(3)使用感(嫌味のなさ)の評価方法
専門家パネラー10人を用いた官能試験により評価した。歯磨剤組成物を歯ブラシ上に1g載せ、普段と同じ方法で3分間ブラッシングを行い、使用中に感じた嫌味について、以下の評点基準で判定した。
<評点基準>
4点:嫌味が全くない
3点:嫌味がほとんどない
2点:嫌味がややある
1点:嫌味がある
10人の評点結果を平均し、以下の評価基準で使用感(嫌味のなさ)を評価した。◎及び○の評価が確保されるものを嫌味のない歯磨剤組成物であると判断した。
<評価基準>
◎:3.5点以上4.0点以下
○:3.0点以上3.5点未満
△:2.0点以上3.0点未満
×:2.0点未満
(3) Evaluation method of usability (no sarcasm) Evaluation was made by a sensory test using 10 expert panelists. 1 g of the dentifrice composition was placed on a toothbrush and brushed for 3 minutes in the same manner as usual, and the sarcasm felt during use was judged according to the following scoring criteria.
<Score criteria>
4 points: No sarcasm 3 points: Almost no sarcasm 2 points: Slightly sarcasm 1 point: Has sarcasm The score results of 10 people are averaged and the usability (no sarcasm) is evaluated according to the following evaluation criteria. did. It was judged that the dentifrice composition having no sarcasm was one in which the evaluations of ⊚ and ○ were ensured.
<Evaluation criteria>
⊚: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: less than 2.0 points

使用した主原料の詳細を下記に示す。
(A)イソプロピルメチルフェノール(4-イソプロピル-3-メチルフェノール、大阪
化成(株)製)
(B)α-オレフィンスルホン酸ナトリウム(ライオン(株)製)
(C)チャエキス(「和ism」、丸善製薬(株)製、エキス分0.2%、抽出溶媒:50%ブチレングリコール水溶液)
トリクロサン(比較品)(イルガサン,チバ・スペシャルティ・ケミカルズ(株)製)
なお、表中の(C)チャエキスの配合量は、いずれもエキス純分量である。
Details of the main raw materials used are shown below.
(A) Isopropylmethylphenol (4-isopropyl-3-methylphenol, manufactured by Osaka Kasei Co., Ltd.)
(B) Sodium α-olefin sulfonate (manufactured by Lion Corporation)
(C) Cha extract ("Wa ism", manufactured by Maruzen Pharmaceuticals Co., Ltd., extract content 0.2%, extraction solvent: 50% butylene glycol aqueous solution)
Triclosan (comparative product) (Ilgasan, manufactured by Ciba Specialty Chemicals Co., Ltd.)
The blending amount of (C) cha extract in the table is the pure amount of the extract.

Figure 0007031253000001
Figure 0007031253000001

Figure 0007031253000002
Figure 0007031253000002

Figure 0007031253000003
Figure 0007031253000003

また、上記実施例1、比較例4,5の歯磨剤組成物について、下記試験を実施した。結果を表4に示した。 In addition, the following tests were carried out on the dentifrice compositions of Examples 1 and Comparative Examples 4 and 5. The results are shown in Table 4.

(4)歯磨き直後の抗菌効果及び抗菌効果の持続性(8時間後)の評価方法-2
ヒトの唾液中の口腔細菌数を測定することで、口腔内細菌への抗菌効果を評価した。
被験者は、無作為に15人ずつの2群(I;歯磨剤群、II;水ブラッシング群(コントロール))に分類した。
各被験者の昼食後の口腔清掃を停止し、そのまま歯磨きすることなく就寝前の唾液を採取した(初期唾液サンプルA)。また、被験者が、歯磨剤組成物を歯ブラシ上に1g載せ、普段と同じ方法で3分間歯をブラッシングし、その直後の唾液を採取した(直後唾液サンプルB)。更に、8時間就寝した後、唾液を採取した(8時間後唾液サンプルC)。採取した唾液サンプルは、それぞれ希釈後、嫌気培養の後、口腔細菌数(Log(cfu/mL))を測定した。前記サンプルA、B、Cの口腔細菌数をそれぞれa、b、cとした。なお、水ブラッシング群(コントロール群)は、歯磨剤組成物を使用せず水を歯ブラシに浸す以外は上記と同様にして唾液サンプルA、B、Cを採取した。
測定結果について、群ごとの初期値に対する口腔細菌数増加率(直後;b/a×100(%)、8時間後;c/a×100(%))の平均値を求め、以下に示す評価基準でそれぞれを判定し、歯磨き直後の抗菌効果と歯磨き後に長時間(8時間)経過した後の抗菌効果の持続性とを評価した。
<評価基準>
◎:歯磨剤群の口腔細菌数増加率がコントロール群に対して25%未満
○:歯磨剤群の口腔細菌数増加率がコントロール群に対して25%以上50%未満
×:歯磨剤群の口腔細菌数増加率がコントロール群に対して50%以上
(4) Evaluation method of antibacterial effect immediately after brushing teeth and sustainability of antibacterial effect (after 8 hours)-2
The antibacterial effect on oral bacteria was evaluated by measuring the number of oral bacteria in human saliva.
Subjects were randomly divided into two groups of 15 each (I; dentifrice group, II; water brushing group (control)).
Oral cleaning after lunch was stopped for each subject, and saliva before bedtime was collected without brushing teeth (initial saliva sample A). In addition, the subject placed 1 g of the dentifrice composition on a toothbrush, brushed the teeth for 3 minutes in the same manner as usual, and collected saliva immediately after that (immediately after saliva sample B). Further, after going to bed for 8 hours, saliva was collected (saliva sample C after 8 hours). The collected saliva samples were diluted, anaerobically cultured, and then the number of oral bacteria (Log (cfu / mL)) was measured. The numbers of oral bacteria in the samples A, B, and C were defined as a, b, and c, respectively. In the water brushing group (control group), saliva samples A, B, and C were collected in the same manner as above except that water was immersed in a toothbrush without using the dentifrice composition.
Regarding the measurement results, the average value of the rate of increase in the number of oral bacteria (immediately after; b / a × 100 (%), 8 hours later; c / a × 100 (%)) with respect to the initial value for each group was obtained, and the evaluation shown below was performed. Each was judged based on the criteria, and the antibacterial effect immediately after brushing and the sustainability of the antibacterial effect after a long time (8 hours) after brushing were evaluated.
<Evaluation criteria>
⊚: Increase rate of oral bacteria in the dentifrice group is less than 25% compared to the control group ○: Increase rate of oral bacteria in the dentifrice group is 25% or more and less than 50% compared to the control group ×: Oral cavity in the dentifrice group Bacterial count increase rate is 50% or more compared to the control group

Figure 0007031253000004
Figure 0007031253000004

Claims (3)

(A)イソプロピルメチルフェノール、
(B)α-オレフィンスルホン酸塩
及び
(C)チャエキス
を含有することを特徴とする歯磨剤組成物。
(A) Isopropylmethylphenol,
A dentifrice composition comprising (B) α-olefin sulfonate and (C) cha extract.
(A)成分を0.001~0.1質量%、(B)成分を0.1~2質量%、(C)成分をエキス純分として0.0007~0.01質量%含有する請求項1記載の歯磨剤組成物。 Claimed to contain 0.001 to 0.1% by mass of the component (A), 0.1 to 2% by mass of the component (B), and 0.0007 to 0.01% by mass of the pure extract of the component (C). 1. The dentifrice composition according to 1. 練歯磨剤である請求項1又は2記載の歯磨剤組成物。 The dentifrice composition according to claim 1 or 2, which is a dentifrice.
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