JP2882017B2 - Oral composition - Google Patents

Description

Description: FIELD OF THE INVENTION The present invention relates to an oral composition such as a dentifrice provided with a bad breath preventing effect by the compounding of a copper compound, and more particularly to the compounding of a copper compound even during long-term storage. The present invention relates to a composition for oral cavity in which discoloration due to lipase is suppressed.

2. Description of the Related Art Conventionally, it is known that copper compounds such as copper gluconate and copper citrate have an antibacterial effect, an effect of removing bad breath, and an effect of inhibiting plaque formation. Various oral compositions have also been proposed (US Patent Nos. 3,044,939 and 3,565,9
No. 33, 3,655,868, 4,112,066, JP-A-56-
No. 169619, No. 56-169620, No. 61-143317, No. 62-14
Nos. 2109 and 62-164614).

However, according to studies by the present inventors, discoloration may occur in oral compositions containing a copper compound when stored for a long period of time. This discoloration is considered to be a discoloration of copper itself and a discoloration caused by a redox reaction of a fragrance or the like which occurs using copper as a catalyst. In any case, it is desired to prevent discoloration due to the compounding of the copper compound.

Means and Action for Solving the Problems In view of the above circumstances, the present inventors have conducted intensive studies on means for preventing discoloration of an oral composition by compounding a copper compound. The present inventors have found that, when an amphoteric surfactant is blended in the composition, there is no discoloration even after long-term storage at a high temperature, and the bad breath suppressing effect of the copper compound is effectively exhibited, and the present invention has been accomplished.

In this case, the discoloration is prevented by the combined use of the copper compound and the amphoteric surfactant as described above because the copper ion and the amphoteric surfactant form a stable coordination compound to suppress free radicals of copper. Therefore, it is considered that discoloration of the composition for oral cavity due to oxidation-reduction reaction of a fragrance or the like that occurs using copper as a catalyst is suppressed.

Heretofore, various oral compositions containing an amphoteric surfactant have been proposed (JP-A-55-118412, JP-A-58-118412).
67808, 58-194806, JP-A-1-213223)
However, it is a new finding by the present inventors that an amphoteric surfactant is added to an oral composition containing a copper compound, whereby discoloration by the copper compound is suppressed.

 Hereinafter, the present invention will be described in more detail.

As described above, the oral composition according to the present invention comprises a copper compound and an amphoteric surfactant in combination.

Here, copper compounds effective for suppressing bad breath include copper gluconate, copper citrate, sodium copper citrate, copper formate,
Copper (II) chloride, copper acetate, cuprous chloride, copper phosphate and the like can be mentioned, and one of these can be used alone or in combination of two or more. Copper gluconate is most suitable in terms of the effect of the above. The compounding amount of these copper compounds is usually from 0.00001 to 2 of the entire composition.
% (% By weight, hereinafter the same), particularly preferably 0.001 to 0.5%. On the other hand, as the amphoteric surfactant, carboxylic acid type (aminoacetic acid type and betaine type), sulfate ester type, sulfonic acid type, phosphate ester type and the like are used. As the aminoacetic acid type, N-lauryl β-alanine, N-
Stearyl β-alanine, N-hydroxyethyl, N-
Dimethylaminopropionic acid and the like, and as the betaine type, lauryl dimethylaminoacetate betaine;
Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and the like. Further, as the sulfate type, N-lauryl N, N-dimethylaminopropylsulfuric acid and the like, and as the sulfonic acid type, N-lauryl-N, N-dimethylaminopropylsulfonic acid, N-
Phosphoric acid ester types such as lauryl-N, N-di-n-propylaminopropylsulfonic acid include P-lauryl-P,
P-dimethylphosphopropylsulfonic acid or the like is used.

Among the amphoteric surfactants described above, betaine type is particularly preferred, and betaine type is preferably betaine lauryldimethylaminoacetate and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

One of the above amphoteric surfactants may be used alone, or two or more may be used in combination. The amount of the amphoteric surfactant is 0.001 to 5% of the whole composition, especially
0.01-1.0% is preferable.

In this case, the copper and the amphoteric surfactant in the copper compound are preferably used in a weight ratio of 10/1 to 1/300, more preferably 1/1 to 1/50. . When the weight ratio exceeds 10/1, the effect of suppressing discoloration in the oral composition may deteriorate, and when the weight ratio is less than 1/300, the deodorizing effect may not be sufficiently exerted.

Oral composition according to the present invention, toothpaste, lubricating toothpaste, dentifrices such as liquid toothpaste, mouthwash, troche, gargle tablets, chewing gum, etc., depending on various uses, paste, liquid, powder, The composition can be prepared in a solid form or the like. In this case, as other components of the oral composition, appropriate components usually used depending on the purpose or the like can be blended. For example, in the case of toothpaste, an abrasive, a binder, a humectant, a surfactant, a sweetener, a fragrance, a preservative, various active ingredients, and the like can be blended.

Effects of the Invention Since the oral composition of the present invention is prepared by combining a copper compound and an amphoteric surfactant, it does not cause discoloration even when stored for a long period of time, and has an excellent bad breath prevention effect.

Next, the effects of the present invention will be specifically described with reference to experimental examples.

〔Example〕

A toothpaste having the composition shown in Table 1 was prepared by a conventional method, filled in a tube, and stored in a thermostat adjusted to 50 ° C for one month. Then, the degree of discoloration of the toothpaste was measured at -5 ° C. And evaluated according to the following evaluation criteria. The results are shown in Table 1.

Toothpaste discoloration score 3: No discoloration is observed compared to the product stored at -5 ° C. 2: Discoloration is slightly observed compared to the product stored at -5 ° C. Be From the results shown in Table 1, it is recognized that the copper compound alone causes discoloration due to long-term storage, and when an amphoteric surfactant is added thereto, the discoloration due to the copper compound is effectively suppressed.

Hereinafter, the present invention will be described specifically with reference to Examples.
The present invention is not limited to the following examples. In addition,
The dentifrices according to the following examples show an excellent deodorizing effect and are very suitable as bad breath prevention dentifrice.

[Example 1] Toothpaste Copper gluconate 0.05% Lauryl dimethylaminoacetic acid betaine 0.2 Aluminum hydroxide 40 Titanium oxide 0.1 Propylene glycol 3.0 Glycerin 20 Carboxymethyl cellulose Sodium 1.0 Carrageenan 0.5 Saccharin sodium 0.2 Sodium lauryl sulfate 1.7 Sodium benzoate 0.2 Methyl paraoxybenzoate 0.2 Fragrance 1.0 Sodium monofluorophosphate 0.73 Purified water Balance 100.0% [Example 2] Toothpaste Copper gluconate 0.02% N-stearin β-alanine 0.3 Silicic anhydride 25 Polyethylene glycol 400 4.0 Sorbit solution (60%) 25 Sodium carboxymethyl cellulose 1.0 Sodium alginate 0.5 Sodium saccharin 0.2 Sodium lauryl sulfate 1.2 Diethanolamide laurate 0.2 Methyl parahydroxybenzoate 0.1 Paraoxybenzo 0.1 Purified water balance Total 100.0% butyl 0.1 Perfume 1.0 Tranexamic acid Example 3 Toothpaste gluconate 0.1% 2-alkyl -N- carboxy-methyl -N- hydroxyimino-da 1.0 sledding betaine aluminum hydroxide 45 Propylene Glycol 2.0 Sorbit solution (60%) 20 Glycerin 10 Sodium polyacrylate 1.5 Sodium saccharin 0.2 Sodium lauryl sulfate 1.5 Sodium benzoate 0.3 Methyl parahydroxybenzoate 0.1 Fragrance 1.0 β-Glutyl retinoic acid 0.1 Purified water Residue 100.0% [Example 4] Toothpaste Copper citrate 0.05% N-lauryl-N, N-dimethylaminopropylsulfonic acid 0.1 Silicic anhydride 30 Aluminum oxide 1.0 Propylene glycol 3.0 Glycerin 30 Xanthan gum 1.5 Dipotassium glycyrrhizinate 0.2 Sodium lauryl sulfate 1.0 N-Lauroyl sal Thin sodium 0.5 Sodium benzoate 0.5 Butyl parahydroxybenzoate 0.1 Perfume 1.0 chlorhexidine gluconate solution 0.05 Purified water balance Total 100.0% Example 5 0.1% toothpaste gluconate 2-alkyl -N- carboxy methyl -N- hydroxy Ethyl 0.3 imidazolinium betaine dicalcium phosphate 40 titanium oxide 0.05 propylene glycol 3.0 sorbite solution (60%) 20 glycerin 20 carboxymethylcellulose sodium 1.0 carrageenan 0.3 sodium saccharin 0.2 sodium lauryl sulfate 1.5 sodium benzoate 0.3 methyl paraoxybenzoate 0.2 flavor 1.0 deki Sutoranaze 500 U / g purified water balance total 100.0% example 6 toothpaste copper citrate 0.1% lauryl betaine 0.5 aluminum hydroxide 45 polyethylene glycol 400 3.0 glycerin Down 25 sodium alginate 1.5 sodium saccharin 0.2 Sucrose laurate 2.0 methyl parahydroxybenzoate 0.2 Perfume 1.0 Sodium fluoride 0.22 Purified water balance Total 100.0% Example 7 toothpaste copper citrate 0.07% N-lauryl -N, N -Dimethylaminopropylsulfonic acid 0.2 Silicic anhydride 20 Propylene glycol 3.0 Sorbite solution (60%) 30 Sodium carboxymethyl cellulose 1.5 Sodium saccharin 0.2 Sodium lauryl sulfate 1.5 Sucrose laurate ester 0.5 Sodium benzoate 0.2 Methyl paraoxybenzoate 0.2 Flavor 1.0 acetate dl-alpha-tocopherol 0.1 purified water balance total 100.0% example 8 toothpaste gluconate 0.05% 2-alkyl -N- carboxy methyl -N- hydroxyethyl 0.1 betaine aluminum hydroxide 40 propylene Glycol 2.5 Glycerin 30 Sodium carboxymethyl cellulose 1.2 Carrageenan 0.3 Saccharin sodium 0.1 dipotassium glycyrrhizinate 0.1 Sodium lauryl sulfate 1.3 N-lauroyl sarcosine sodium 0.3 Sodium benzoate 0.3 Methyl parahydroxybenzoate 0.1 Perfume 1.0 glycine 0.03 Purified water balance Total 100.0%

Claims (1)

(57) [Claims] An oral composition comprising a copper compound and an amphoteric surfactant.