JPH10212220A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition which affords excellent effect of preventing foul breath during a long period of time and fine feeling in use by blending a bactericide, a specific surfactant and a (bi)carbonate of alkali metal. SOLUTION: This oral composition is obtained by blending (A) 0.001-5wt.% of a bactericide (e.g. benzethonium chloride), (B) 0.01-10wt.% of a nonionic surfactant (e.g. a polyoxyethylene cetyl ether) and/or an amphoteric surfactant [e.g. a 2-alkyl (8-16C)-N-carboxymethyl-N-hydroxyethylimidazolinium betain], (C) 0.001-30wt.% of a (bi)carbonate of alkali metal (e.g. sodium bicarbonate) and when necessary, (D) caking additives, humectants, abrasives, sweeteners, gelatin, titanium dioxide pigments. This composition is efficient when prepared and applied as moth-washing solutions, liquid dentifrice, aqueous dentifrice, gargling medicines and liquid oral compositions free from abrasives such as mouth refrigerant and the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition such as a mouthwash having a good effect of preventing bad breath for a long time.

[0002]

2. Description of the Related Art
Attempts have been made to incorporate a bactericide into the oral composition to prevent bad breath, but especially in oral compositions, it has become common to wash the oral cavity with water after its application. However, as a result, the disinfectant is removed from the oral cavity, so that the effect cannot be sufficiently exhibited, and it is particularly difficult to maintain the effect for a long time. In this case, it is conceivable that the amount of the fungicide may be left in the oral cavity by increasing the amount of the fungicide, but this is not desirable considering that the taste is significantly impaired and coloring is taken into consideration.

The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a composition for oral cavity which provides an excellent effect of preventing bad breath over a long period of time and has a good feeling in use.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above-mentioned object, and as a result, the bactericide was treated with a nonionic surfactant and / or an amphoteric surfactant. Surprisingly, by using a combination of an agent and a bicarbonate and / or carbonate of an alkali metal, a mouthwash such as a mouthwash exhibiting a stable and good bad breath prevention effect for a long time after application. It has been found that a composition is obtained.

That is, although oral compositions using a nonionic surfactant or an amphoteric surfactant in combination with a bactericide are known, even when both are used in combination, the results of Examples and Comparative Examples described below are obtained. As is clear from the above, there is no effect of preventing bad breath for a long time. Further, even when a disinfectant is used in combination with an alkali metal bicarbonate or an alkali metal carbonate, it does not have the effect of preventing bad breath for a long time. Furthermore, the combination of a nonionic surfactant or amphoteric surfactant with a bicarbonate or carbonate of an alkali metal does not provide an effect of preventing bad breath. However, when a fungicide, a nonionic surfactant and / or an amphoteric surfactant, and a bicarbonate and / or a carbonate of an alkali metal are used in combination, an effect of preventing bad breath over a long period of time. It has been found that the effect of preventing bad breath for a long time can be remarkably exerted in a system containing no anionic surfactant and more effectively exerted in a liquid system such as a mouthwash. It is something that has been done.

Hereinafter, the present invention will be described in more detail.
Oral composition according to the present invention, mouthwash, liquid dentifrice, water dentifrice, gargle, prepared as a liquid oral composition containing no abrasive such as mouth freshener, it is effective to apply, It can also be prepared and applied to systems containing an abrasive such as liquid toothpaste and toothpaste, and paste systems.

The oral composition of the present invention comprises a bactericide, a nonionic surfactant and / or an amphoteric surfactant, and a bicarbonate and / or carbonate of an alkali metal. As a result, the effect of the disinfectant is maintained, and an effective bad breath prevention effect is provided over a long period of time.

In this case, as a bactericide to be incorporated in the oral composition, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, isopropylmethylphenol, triclosan, hinokitiol and the like are preferably used. The amount is desirably 0.001 to 5% by weight, especially 0.001 to 2% by weight of the whole composition.

As the nonionic surfactant to be incorporated in the composition, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, fatty acid diethanolamide, polyoxyethylene polyoxypropylene glycol, or the like is used. In particular, polyoxyethylene polyoxypropylene glycol (25 to 300 EO, 30 to 70 P
O), polyoxyethylene cetyl ether (2-40E)
O), polyoxyethylene stearyl ether (2-2)
0EO) and polyoxyethylene sorbitan oleate (40EO) are preferably used. On the other hand, as the amphoteric surfactant, an imidazoline type and a betaine acetate type can be used. In particular, 2-alkyl (C ₈ -C ₁₈ ) -N-carboxymethyl-N-hydroxyethylimidazolinium betaine is suitably used. . The compounding amount is desirably 0.01 to 10% by weight, particularly 0.05 to 5% by weight of the whole composition.

As the alkali metal bicarbonate and / or carbonate, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, potassium sodium carbonate, sodium sesquicarbonate and potassium sesquicarbonate can be suitably used. These may be used alone or in combination of two or more. The compounding amount of the bicarbonate and / or carbonate of these alkali metals is 0.1% of the whole composition.
It is desirably 001 to 30% by weight, particularly 0.1 to 25% by weight.

[0011] In addition to the above components, the oral composition of the present invention may contain, as other components, appropriate components which are ordinarily used in accordance with the type and purpose of use of the oral composition.

Examples of the binder include cellulose derivatives such as sodium carboxymethylcellulose; alkali metal alginate such as sodium alginate; gums such as xanthan gum and gum arabic; synthetic binders such as sodium polyacrylate and polyvinylpyrrolidone; And one or more kinds of inorganic binders such as laponite (usually in an amount of 0.1 to 10% by weight).

Further, as a wetting agent, one or more of sorbitol, glycerin, propylene glycol, polyethylene glycol, xylit and the like can be blended (normally 1 to 70% by weight).

One or more abrasives such as dibasic calcium phosphate, aluminum hydroxide, and silicic anhydride (usually in an amount of 0.1 to 80% by weight, preferably 1 to 60% by weight)
% By weight). One or more alcohols such as ethanol (0 to 70% by weight, preferably 0 to 30% by weight) may be blended as a solvent.

The oral composition of the present invention further comprises a sweetener (0 to 1% by weight, preferably 0.01 to 0.5% by weight) such as sodium saccharin, stevioside, and aspartame, gelatin, titanium dioxide, a pigment, Other components can be blended and the desired component can be manufactured by mixing with an appropriate amount of water.

Further, in the present invention, tranexamic acid,
Antiplasmins such as epsilon aminocaproic acid, vitamins such as ascorbate and tocopherol salts, glycyrrhizin salts, allantoins, enzymes such as oak, dextranase and mutanase, alkali metal monofluorophosphates such as sodium monofluorophosphate One or more active ingredients such as sodium fluoride, fluorides such as stannous fluoride, inorganic salts such as sodium chloride and potassium nitrate, sodium copper chlorophyllin, zeolite, and water-soluble inorganic phosphate compounds may be blended. . The compounding amount is usually an appropriate amount from efficacy and palatability, that is, 0.001 to 0.001.
10% by weight, more preferably 0.005 to 2% by weight can be blended.

[0017]

The oral composition of the present invention effectively exerts the effect of preventing bad breath over a long period of time.

[0018]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

Examples 1 to 16 and Comparative Examples 1 to 10 In order to confirm the persistence of the effect of preventing oral malodor of the oral composition according to the present invention, mouthwashes having the formulations shown in Tables 1 to 3 were prepared. , Part 1
0 ml was taken in the mouth, rinsed for 20 seconds, and discharged.
After 60 minutes, the presence or absence of bad breath was determined by sensory evaluation using a specialized panel. The results are shown in Tables 1 to 3.

From the results shown in the table, the mouthwashes of the examples in which three kinds of fungicides, nonionic surfactants or amphoteric surfactants, and bicarbonates or carbonates of alkali metals were used in combination were obtained after 60 minutes. The effect of preventing bad breath persisted. However, the effect of preventing bad breath was not recognized by using only two of the three components.

[0021]

[Table 1]

[0022]

[Table 2]

[0023]

[Table 3]

Example 17 Toothpaste 5.0% by weight Sodium bicarbonate 5.0% by weight Calcium diphosphate 45.0 Sodium carboxymethylcellulose 1.5 Imidazolinium betaine 1.0 Polyoxyethylene stearyl ether 0.5 Sorbit solution 20.0 Propylene glycol 5.0 Dextranase 0.01 Chlorhexidine hydrochloride 0.05 Saccharin sodium 0.01 Fragrance 1.0 Purified water Residual total 100.0% by weight

Example 18 Liquid Toothpaste Sodium Bicarbonate 3.0% by Weight Sodium Carbonate 1.0 Silicic Anhydride 10.0 Sodium Alginate 0.5 Imidazolinium Betaine 1.5 Glycerin 40.0 Polyethylene Glycol # 400 5 0.0 Allantoin 0.05 Benzalkonium chloride 0.05 Stevioside 0.02 Food color blue No. 1 0.0001 Fragrance 1.0 Purified water Remaining total 100.0% by weight

Example 19 Liquid Toothpaste Sodium Bicarbonate 3.0% by Weight Sodium Chloride 5.0 Propylene Glycol 5.0 Ethanol 2.0 Polyoxyethylene Polyoxypropylene Glycol 0.5 Tranexamic Acid 0.05 Oubaku Extract 0 .05 Isopropyl methyl phenol 0.05 Saccharin sodium 0.01 Fragrance 0.5 Purified water Remaining total 100.0% by weight

Example 20 Gargle Sodium sesquicarbonate 1.0% by weight Sodium fluoride 0.5 Hinokitiol 0.1 Polyoxyethylene cetyl ether 1.0 Imidazolinium betaine 1.0 Aspartame 0.01 Fragrance 0. 5 Purified water remaining 100.0% by weight

Claims (1)

[Claims] 1. An oral composition comprising a fungicide, a nonionic surfactant and / or an amphoteric surfactant, and a bicarbonate and / or carbonate of an alkali metal.