JP2002255771A - Liquid composition for oral cavity not mixed with alcohol - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a liquid composition for the oral cavity not mixed with alcohol, controlling coloration of teeth with a cationic germicide. SOLUTION: This liquid composition for the oral cavity not mixed with alcohol controls the coloration of teeth with the cationic germicide by formulating (a) a cationic germicide with (b) a polyoxyethylene hardened castor oil and (c) a polyethylene glycol having 200-800 average molecular weight.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a liquid oral composition containing no alcohol, which suppresses the coloring of teeth by a cationic fungicide.

[0002]

2. Description of the Related Art Removal of plaque (plaque) which causes caries and periodontitis and prevention of adhesion (plaque control) are important in oral hygiene. BACKGROUND ART Conventionally, oral compositions containing a cationic antibacterial agent for the purpose of sterilizing plaque bacteria have been proposed. However, when a cationic fungicide is used for a long time, there is a problem that teeth are colored.

[0003] In order to solve the problem of tooth coloring caused by the use of a cationic fungicide, for example, WO-9316681 discloses a cationic fungicide by using an oral composition comprising a combination of a cationic fungicide and polyvinylpyrrolidone. It is described that the coloring of the teeth due to is suppressed. However, polyvinylpyrrolidone has poor stability in pharmaceutical systems,
There is a problem that discoloration of the preparation occurs due to long-term storage.
JP-A-57-188510 discloses that by adjusting the pH of a quaternary ammonium compound and a tetraalkali metal pyrophosphate to a specific pH, tooth coloring derived from a quaternary ammonium compound can be reduced. Has been described. However, tetraalkali metal pyrophosphate has a problem that taste is bad. That is, in any of the above cases, the effect cannot be said to be sufficient.

[0004] Polyethylene glycol is mainly blended as a dispersant or wetting agent for the purpose of stabilizing the preparation. For example, JP-A-56-77221 discloses that a specific polyethylene glycol is blended in a transparent dentifrice composition containing an anionic activator to prevent precipitation of the anionic activator at a low temperature. It states that it can. Also, JP-A-03-109315 discloses that
An aqueous gel composed of a polyoxyethylene / polyoxypropylene block copolymer-based surfactant is mixed with cetylpyridinium chloride and a specific amount of polyethylene glycol.
A dentifrice composition which stably blends cetylpyridinium chloride by blending with benzene and has good properties is described. Further, Japanese Patent Application Laid-Open No. 09-510192 discloses a particulate silica abrasive stably suspended with a precipitation inhibitor such as xanthan gum, a wetting agent system containing sorbitol and polyethylene glycol of a specific molecular weight. It is described that a liquid dentifrice comprising is excellent in tooth cleaning properties. None of them mentions the suppression of tooth coloring by a cationic fungicide.

[0005]

That is, an object of the present invention is to provide a liquid oral composition containing no monohydric alcohol, which suppresses tooth coloring by a cationic fungicide.

[0006]

Means for Solving the Problems The inventors of the present invention have made intensive studies in view of such circumstances, and as a result, have found that a liquid oral cavity containing no alcohol containing a polyoxyethylene hydrogenated castor oil and polyethylene glycol mixed with a cationic fungicide. The composition has been found to inhibit the coloring of teeth by a cationic fungicide, and has completed the present invention.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The cationic fungicide used in the alcohol-free liquid oral composition of the present invention is not particularly limited, but cetylpyridinium chloride or chlorhexidine salts are preferred. The compounding amount is from 0.01 to 0.1% by weight based on the total amount of the composition.
If it is more than 1% by weight, bitterness may occur.

[0008] The polyoxyethylene hydrogenated castor oil used in the liquid oral composition containing no monohydric alcohol of the present invention is not particularly limited, but the number of moles of ethylene oxide added is preferably 10 to 100 moles. Especially 40
~ 60 mol is preferred. The compounding amount is preferably from 0.01 to 5% by weight, particularly preferably from 0.1 to 1% by weight, based on the total amount of the composition. If the amount is less than 0.01% by weight, sufficient solubilizing power may not be obtained, and if the amount is more than 5% by weight, the bactericidal activity may decrease due to incorporation of the cationic bactericide into micelles.

[0009] The polyethylene glycol of the present invention preferably has an average molecular weight of 200 to 800.
It is preferably from 1:30 to 1: 100, and more preferably from 1 to 5% by weight based on the total amount of the composition. If it is less than 1% by weight, suppression of tooth coloring is insufficient, and if it is more than 5% by weight, a problem of bitterness occurs.

[0010] The alcohol-free liquid oral composition of the present invention can be provided in the form of liquid dentifrice, mouthwash, rinse, low-viscosity gel and the like. The term “alcohol-free liquid oral composition” as used herein means a monohydric alcohol-free liquid oral composition, particularly an ethanol-free liquid-free oral composition.

[0011] In addition to the above components, the alcohol-free liquid oral composition of the present invention may further contain the following appropriate components according to the form of the composition as long as the effects of the present invention are not impaired. Can be.

For example, the surfactant can be selected from nonionic surfactants and amphoteric surfactants. For example,
Nonionic surfactants include sucrose fatty acid esters, maltose fatty acid esters, sugar fatty acid esters such as lactose fatty acid esters, fatty acid alkanolamides,
Sorbitan fatty acid esters, fatty acid monoglycerides,
Polyoxyethylene addition coefficient is 8 to 10, polyoxyethylene alkyl ether type having 13 to 15 carbon atoms in the alkyl group or polyoxyethylene addition coefficient is 10 to 10.
18, a polyoxyethylene alkylphenyl ether nonionic surfactant having an alkyl group having 9 carbon atoms, and the like. Examples of the amphoteric surfactant include N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiethylglycine, N-alkyl-N-carboxymethylammonium betaine, and sodium 2-alkyl-1-hydroxyethylimidazoline betaine. Can be These surfactants may be used alone or in combination of two or more. The compounding amount is usually 0.01 to 30% by weight, preferably 0.1 to 5% by weight based on the total amount of the composition.

As a flavoring agent, menthol, carboxylic acid,
Anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronell,
α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool, ethyl linalool, thymol, spearmint oil,
A composition comprising a fragrance such as peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, and pigment oil, alone or in combination of two or more. It can be blended at a ratio of about 0.1 to about 5% by weight, preferably about 0.5 to 5% by weight based on the total amount.

Further, a sweetener such as saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanyl methyl ester, and ρ-methoxycinnamic aldehyde is added to the total amount of the composition. It can be added at a ratio of 0.01 to 1% by weight, preferably 0.05 to 0.5% by weight.

In the oral composition of the present invention, alkali metal alginate such as cationized hydroxyethylcellulose and sodium alginate, propylene glycol alginate, xanthan gum, tragacanth gum and karaya gum are used in order to impart a viscosity that does not impair the feeling of use. Gums such as gum arabic, carrageenan, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, synthetic binders such as polyvinylpyrrolidone, silica gel, aluminum silica gel, veegum, one of inorganic binders such as laponite or Two or more can be blended. The amount of these compounds is usually 0.1% by weight or less.

Further, as humectants, sorbitol, glycerin, ethylene glycol, propylene glycol,
1,3-butylene glycol, polypropylene glycol, xylit, maltit, lactit and the like can be used alone or in combination of two or more. The compounding amount is usually 3 to 70% by weight based on the total amount of the composition.

In the oral composition of the present invention, vitamin E such as dl-α-tocopherol acetate, tocopherol succinate or tocopherol nicotinate, and dodecyl diaminoethyl glycine as active ingredients other than the cationic bactericide. Non-ionic fungicides such as amphoteric fungicides, triclosan, isopropylmethylphenol, etc.
Enzymes such as dextranase, amylase, protease, mutanase, lysozyme, and lytic enzyme (Litek enzyme), alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, sodium fluoride, and first fluoride Fluoride such as tin, tranexamic acid or epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyrrhizin salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, sodium chloride, caropeptide, water-soluble inorganic phosphate compound, etc. More than one species can be combined and blended.

[0018]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. In Examples, [%] is [% by weight] unless otherwise specified. The evaluation method is described below. 1. Tooth coloring evaluation test Acrylic plate (10 mm x 30 mm x 5 mm) 0.3%
Soak in bovine serum albumin for 2 minutes. The acrylic plate is immersed in distilled water for 30 seconds, washed, and then immersed in a test sample for 2 minutes. After washing by immersion in distilled water for 30 seconds, black tea (10 g /
Extracted with 1000 ml of boiling water and passed through gauze after 2 minutes to remove the leaves) and soaked for 60 minutes. After washing by immersion in distilled water for 30 seconds, air drying is performed. The above operation was repeated 10 times, and the coloring of the acrylic plate surface was measured at a measurement wavelength of 395 n.
Measure absorbance in m.

2. Evaluation criteria: Evaluation was made as follows according to the absorbance. The larger the value of the evaluation criterion, the higher the effect of suppressing tooth coloring. Table 1 shows the results.

[0020]

[Table 1]

According to the results shown in Table 1, the average molecular weight is 200 to 8
The test samples of Examples 1 to 3 containing 1.0% to 5.0% of polyethylene glycol of Comparative Example 1 were Comparative Example 1 containing no polyethylene glycol or having an average molecular weight of 100.
Comparative Examples 2 and 3 containing 0 polyethylene glycol
It is clear that the tooth coloring inhibition effect is extremely excellent as compared with the test sample of Example 1. Furthermore, when the polyoxyethylene hydrogenated castor oil was not blended as in the test sample of Comparative Example 4, it was found that the effects as in the test samples of Examples 1 and 4 were not obtained.

Example 5 A mouthwash was produced according to the following formulation according to a conventional method. Component name Content (%) Glycerin 15.0 Polyoxyethylene hydrogenated castor oil (EO) 4.0 Polyethylene glycol 400 3.0 Fragrance 0.1 Sodium saccharin 0.01 Cetylpyridinium chloride 0.05 Sodium citrate 0.05 Acetic acid Tocopherol 0.02 Sodium fluoride 0.05 Purified water Remainder Total 100.0 The obtained mouthwash was evaluated by the above-described tooth coloring evaluation test method and showed an excellent inhibitory effect.

Example 6 A liquid dentifrice was produced according to the following formulation according to a conventional method. Component name Content (%) Sorvit 10.0 Polyoxyethylene hydrogenated castor oil (EO) 5.0 Fragrance 0.05 Polyethylene glycol 400 5.0 Saccharin sodium 0.01 Chlorhexidine gluconate 0.05 Sodium citrate 0.05 Acetic acid Tocopherol 0.02 Sodium fluoride 0.05 Purified water Remainder Total 100.0 The obtained liquid dentifrice was evaluated by the above-described tooth coloring evaluation test method and showed an excellent inhibitory effect.

Example 7 A low-viscosity gel was produced according to the following formulation according to a conventional method. Component name Content (%) Sorbit 10.0 Polyoxyethylene hydrogenated castor oil (EO) 3.0 Fragrance 0.2 Polyethylene glycol 400 1.0 Saccharin sodium 0.01 Chlorhexidine gluconate 0.05 Hydroxyethyl cellulose 0.01 Tocopherol acetate 0.05 Sodium fluoride 0.05 Purified water Remainder Total 100.0 The obtained low-viscosity gel was evaluated by the above-mentioned tooth coloring evaluation test method, and showed an excellent inhibitory effect.

[0025]

Effect of the Invention According to the present invention in which polyoxyethylene hydrogenated castor oil and polyethylene glycol are blended with a cationic fungicide, an alcohol-free liquid oral composition that suppresses tooth coloring by the cationic fungicide is provided. it can.

Claims (4)

[Claims] 1. A cationic fungicide, (b) polyoxyethylene hydrogenated castor oil, and (c) an average molecular weight of 200 to 80.
An alcohol-free liquid oral composition comprising 0 polyethylene glycol. 2. The liquid oral composition according to claim 1, wherein the cationic fungicide is cetylpyridinium chloride or chlorhexidine salt. 3. The compounding amount of the cationic bactericide is 0.01 to 3.0.
The alcohol-free liquid oral composition according to any one of claims 1 and 2, which is 0.1% by weight. 4. The compounding ratio of polyethylene glycol to the cationic germicide is 1:30 to 1: 100, and the compounding amount of polyethylene glycol is 1 to 1 to the total amount of the composition.
The alcohol-free liquid oral composition according to any one of claims 1 to 4, which is 5% by weight.