JP2000344641A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity with excellent low-temperature storage stability, fanciness and feeling when used. SOLUTION: This composition for oral cavity is obtained by including erythritol and also formulating 1-menthol and at least one kind of fragrance ingredient selected from anethole, menthone, cineole, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinnamaldehyde, and trans-2-hexenal in the weight ratio of (50:1) to (2:8).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an oral composition containing erythritol.

[0002]

2. Description of the Related Art
Erythrit is mainly used in foods and the like as an alternative sweetener, but its application to oral compositions has been proposed because it is a non-cariogenic carbohydrate (Japanese Patent Application Laid-Open No. 10-33138). Gazette). However, since erythritol has low solubility, when it is added to an oral composition, there is a problem that low-temperature storage stability is inferior, and that palatability and usability deteriorate.

[0003] The present invention has been made in view of the above circumstances, and has as its object to provide an erythritol-containing oral composition having excellent low-temperature storage stability and excellent palatability and usability.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, in an oral composition containing erythritol, anethole, menthone, One or more fragrance components selected from cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinamic aldehyde and trans-2-hexenal, and 1-menthol in a ratio of 1:50. The present inventors have found that by blending at a weight ratio of about 8: 2, excellent low-temperature storage stability, palatability, and usability can be ensured, and the present invention has been accomplished.

Hereinafter, the present invention will be described in more detail.
The oral composition of the present invention contains erythritol and is selected from among anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinamic aldehyde, and trans-2-hexenal. One or two or more flavor components and l-menthol are mixed in a ratio of 1:50 to 8: 2.
In the weight ratio of

Here, the structure of erythrite is L
There are three isomers, -erythritol, D-erythritol, and meso-erythritol, but the present invention does not depend on these structures. As the erythritol used in the present invention, those produced by fermenting glucose are mainly used, and those manufactured by Niken Chemical Co., Ltd., Mitsubishi Chemical Co., etc. can be used.

The amount of erythritol is 0.1% in the composition.
-35% (% by weight, hereinafter the same), particularly preferably 0.3-25%.

[0008] The flavor component used in the present invention is one selected from anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinamic aldehyde, and trans-2-hexenal. Or two or more kinds, and the present invention uses this flavor component in combination with l-menthol.
In this case, the combination ratio of the above-mentioned perfume component and l-menthol is 1:50 to 8: 2, preferably 1:30 to 7: as a weight ratio from the viewpoint of low-temperature storage stability, palatability and feeling of use.
3, more preferably 1:20 to 5: 5. If the proportion of l-menthol is too large, the stability in low-temperature storage will decrease. If the proportion of l-menthol is too small, the palatability is reduced.

The above-mentioned perfume component and 1-menthol are contained in the composition in a total amount of 0.01 to 2%, more preferably 0.1 to 2%.
It is preferable to mix 1 to 1%.

These fragrance components may be blended individually, but may be blended with an essential oil or the like containing them, such as spearmint oil in the case of carvone.
Further, when l-menthol is used in combination with the above fragrance component, essential oils and the like containing the same, such as peppermint oil,
You may mix Japanese peppermint oil and the like.

Further, in addition to the above-mentioned perfume components, perfume components such as aliphatic alcohols and esters thereof, terpene hydrocarbons, phenol ethers, aldehydes, ketones and lactones, and essential oils are blended within a range not to impair the effects of the present invention. No problem.

The oral composition of the present invention includes dentifrices such as toothpastes, liquid dentifrices, liquid dentifrices, gel dentifrices, mouthwashes, coatings, mouthwashes, dental pasta, denture cleaners, chewing gums and troches. It can be prepared as such.

The oral composition of the present invention may contain other additives as optional components in addition to the above essential components, depending on the dosage form and the like.

In the case of dentifrices, for example, abrasives, thickeners,
Binders, surfactants, sweeteners, preservatives, active ingredients, pigments and the like can be blended, and can be produced by mixing these ingredients with water.

Examples of the abrasive include silica-based abrasives such as silica gel, precipitated silica, igneous silica, aluminosilicate and zirconosilicate, dibasic calcium phosphate, dibasic calcium phosphate anhydrate, calcium pyrophosphate,
Aluminum hydroxide, alumina, light calcium carbonate,
Heavy calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, fluoroapatite, calcium-deficient apatite, quaternary calcium phosphate, octacalcium phosphate, synthetic resin-based abrasives, etc. These may be used alone or in combination of two or more. These amounts are 1 to 1 of the whole composition.
It is preferably 60%, particularly preferably 5 to 40%.

As the thickener, glycerin, sorbitol, propylene glycol, polyethylene glycol,
Ethylene glycol, reduced starch saccharified product, xylitol, polyhydric alcohols such as maltitol and the like,
One or more of these may be used.

Examples of the binder include inorganic binders such as xanthan gum, sodium alginate, propylene glycol alginate, carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, carrageenan, carbopol, guar gum, gelatin, Avicel, montmorillonite, kaolin and bentonite. One or more of these can be used.

Examples of the surfactant include an anionic surfactant, a cationic surfactant, and a nonionic surfactant. Specific examples thereof include sodium lauryl sulfate, sodium N-lauroyltaurine, N-acyl sarcosinate, α-olefin sulfone. Acid, N-acylamino acid, N-acylglutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N
Acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, pluronic, decaglyceryl laurate and the like.

As sweeteners, sodium saccharin,
Use aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin, etc., as preservatives, use parabens such as butyl paraben, ethyl paraben, paraoxybenzoate, sodium benzoate, etc. Is possible.

In the present invention, dextranase, amylase, protease, mutanase, superoxide dismutase, lysozyme, litechenzyme, lytic enzyme and other enzymes, antibodies, alkali metal monofluorophosphate such as sodium monofluorophosphate are used as active ingredients. Fluoride such as sodium fluoride, potassium fluoride, potassium tin fluoride, strontium fluoride, stannous fluoride, stannous compound, hinokitiol, ascorbic acid, chlorhexidine salts, triclosan, epsilon aminocaproic acid, tranexamic acid, Aluminum hydroxyl allantoin, dihydrocholesterol,
Glycyrrhizates, glycyrrhetinates, glycerophosphate, chlorophyll, copper gluconate, cetylpyridinium chloride, lysozyme chloride, benzalkonium chloride, benzethonium chloride, bisabolol, dl-tocopherol acetate, isopropylmethylphenol, sodium chloride, orthophosphoric acid Potassium salts, water-soluble inorganic phosphate compounds such as sodium salts, polyethylene glycol, potassium nitrate, aluminum lactate, berberine, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, Epidihydrocholesterine, trichlorocarbanide, zinc citrate, soft oyster extract, oak extract, clove, rosemary, ogon, safflower etc. The active ingredient of the extract, such as one or
More than one species may be blended.

[0021] The amounts of these components can be set to ordinary amounts as long as the effects of the present invention are not impaired.

The oral composition such as toothpaste thus obtained can be used in aluminum tubes, laminate tubes, glass deposition tubes, plastic tubes, bottle containers, aerosol containers and the like. It is possible to use a container whose inner surface has been treated as necessary.

[0023]

EFFECTS OF THE INVENTION The erythritol-containing oral composition of the present invention is excellent in low-temperature storage stability, palatability and usability.

[0024]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to experimental examples and examples, but the present invention is not limited to these examples. In the following examples,% is% by weight unless otherwise specified.
Is shown. Further, in the following examples, "flavor" is anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol,
It is a preparation containing no thymol, cinnamaldehyde, trans-2-hexenal, and 1-menthol.

[Experimental Examples] Toothpaste compositions were prepared from the components shown in Table 1 by a conventional method, and various characteristics were evaluated according to the following methods. The results are shown below.

[0026]

[Table 1] * Eritrite: manufactured by Niken Chemical Co., Ltd.

(1) Feeling of use (actual use, exhilaration, quality of foam) Evaluation method: Evaluation was carried out by a sensory test by a specialized panelist. Actual feeling of use Invention product >> Comparative example 1> Comparative example 2 = Comparative example 4> Comparative example 3 Refreshing invention product >> Comparative example 3> Comparative example 1 = Comparative example 2> Comparative example 4 Foam quality Invention product >> Comparative example 1> Comparative Example 2> Comparative Example 4> Comparative Example 3

(2) Stability: The stability of each dentifrice was measured after storing each dentifrice in a thermostat at -5 ° C. for one month. Temperature (° C) Inventive product Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Low temperature liquid separation -5 ○ △ ○ ○ △ Low temperature skin roughness -5 ○ ○ × × ○ Low temperature extrudability -5 ○ ○ × × ○ Low temperature moldability -5 ○ ○ △ △ ○ ○: Good △: Acceptable ×: Not possible

(3) Preference: Evaluation method: Special panel 2
It was evaluated by a sensory test by 0 persons. Evaluation item Inventive product Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Feeling that plaque fell ○ △ △ △ △ Mouth feel during use ○ △ ○ △ ○ Cool feeling after polishing ○ × △ ○ ×

Comprehensive evaluation: Comprehensive evaluation based on evaluation items (1) to (3) Evaluation items Invention product Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Overall evaluation ○ △ × × △

From the above results, it has been clarified that the oral composition according to the present invention is excellent in low-temperature storage stability, usability, and palatability.

Examples are shown below. In the following examples, erythrit is manufactured by Mitsubishi Chemical Corporation and dextranase is 120
00u / g manufactured by Sankyo Co., Ltd.

Example 1 Toothpaste Dibasic calcium phosphate 50% sorbitol 20 sodium lauryl sulfate 0.7 erythrit 0.5 lauric acid diethanolamide 1.2 carrageenan 1.0 saccharin sodium 0.1 flavor 0.3 l-menthol 7 Anethole 0.2 water balance 100.0%

Example 2 Toothpaste Aluminum Hydroxide 35% Silicic Anhydride 2 Sorbite 15 Glycerin 15 Coconut Oil Alcohol Sodium Sulfate 0.5 Erythrit 1.5 Sodium Alginate 1.0 Gelatin 0.5 Saccharin Sodium 0.1 Fragrance 0. 8 l-menthol 0.3 anethole 0.05 water balance 100.0%

Example 3 Toothpaste Dibasic calcium phosphate 45% Sorbit 25 Sodium lauryl sulfate 1.0 Erythrit 0.5 Carrageenan 0.2 CMC 0.8 Propylene glycol 4.0 Saccharin sodium 0.2 Silicic anhydride 3.0 Glycyrrhizin Dipotassium acid 0.05 tranexamic acid 0.05 fragrance 0.7 eugenol 0.1 l-menthol 0.4 water balance 100.0%

Example 4 Toothpaste Aluminum Hydroxide 40% Glycerin 20 Sodium Lauryl Sulfate 1.0 Erythrit 10.0 Sodium Monofluorophosphate 0.5 CMC 1.3 Propylene Glycol 4.0 Saccharin Sodium 0.2 Silicic Anhydride 3.0 dextranase 0.2 fragrance 1.0 anethole 0.1 l-menthol 0.4 water balance 100.0%

Example 5 Toothpaste Dibasic calcium phosphate 40% Sorbit 30 Sodium lauryl sulfate 1.2 Erythrit 0.6 CMC 0.9 Propylene glycol 3.0 Saccharin sodium 0.2 Silicic anhydride 2 Vitamin E 0.5 Glycyrrhetinic acid 0.05 tranexamic acid 0.05 oat extract 0.05 perfume 0.4 l-menthol 0.5 ethyl butyrate 0.3 water balance 100.0%

Example 6 Toothpaste 30% Calcium Carbonate 30% Sorbit 20 Sodium Lauryl Sulfate 0.8 Erythrit 0.4 CMC 1.3 Sodium Saccharin 0.02 Silicic Anhydride 3.0 Ougon Dry Extract 0.001 Sodium Monofluorophosphate 0.5 Sodium chloride 10 Fragrance 0.8 1-Menthol 0.4 Ethyl butyrate 0.2 Water Residual 100.0%

Example 7 Toothpaste Aluminum Hydroxide 40% Sorbit 20 Hydroxyethyl Cellulose 0.5 Sodium Lauryl Sulfate 2.0 Carrageenan 0.5 Sodium Saccharin 0.1 Diethanolamide Laurate 1.0 Propylene Glycol 2.0 Aluminum Lactate 2 0.0 Erythrit 0.4 Triclosan 0.3 Sodium monofluorophosphate 0.4 Decaglyceryl laurate 0.5 Fragrance 0.6 1-Menthol 0.4 Methyl salicylate 0.1 Water Residue 100.0%

Example 8 Dentifrice Silica 15% Sorbite 30 Glycerin 18 Sodium Lauryl Sulfate 0.9 Sodium Alginate 0.4 Sodium Saccharin 0.05 Erythritol 20 Lauric Diethanolamide 1 Propylene Glycol 2 Dipotassium Glycyrrhizinate 0.05 Triclosan 0. 02 Sodium fluoride 0.2 Decaglyceryl laurate 0.5 Dextranase 1.5 0.1% Blue No. 1 0.8 Fragrance 0.5 1-Menthol 0.5 Limonene 0.1 Water Balance 100.0 %

Example 9 Dentifrice Silica 18% Sorbite 50 Glycerin 18 Sodium Lauryl Sulfate 1.0 Erythrit 0.5 Xanthan Gum 0.8 Saccharin Sodium 0.1 Gelatin 0.2 Lauric Diethanolamide 1.0 Propylene Glycol 2.0 Triclosan 0.3 Sodium fluoride 0.2 Dextranase 0.15 Fragrance 0.4 1-Menthol 0.5 Cinamic aldehyde 0.1 Water Balance 100.0%

Example 10 Toothpaste Silica 13% Sorbite 30 Glycerin 20 Sodium Lauryl Sulfate 0.9 Erythrit 25 Sodium Alginate 0.3 Sodium Saccharin 0.1 Sodium Sulfate Anhydrous 0.3 Diethanolamide Laurate 1.0 Propylene Glycol 2. 0 Tripolyphosphoric acid 0.5 Dipotassium glycyrrhizinate 0.05 Triclosan 0.02 Sodium monofluorophosphate 0.5 Decaglyceryl laurate 0.5 Fragrance 0.5 1-Menthol 0.4 Thymol 0.1 Water Balance 100. 0%

Example 11 Mouthwash Denatured Ethanol 18% Polyoxyethylene hydrogenated castor oil 2.0 (EO = 60) Sodium myristyl sulfate 1.0 Erythrit 14 Glycerin 10 Citric acid 0.01 Trisodium citrate 0. 3 Sodium fluoride 0.08 Fragrance 0.2 l-Menthol 0.3 Ethyl butyrate 0.1 Water Balance 100.0%

Example 12 Mouthwash Glycerin 20% Sodium Myristyl Sulfate 1.0 Erythrit 0.5 Sodium Saccharin 0.1 Ethanol 3.0 Fragrance 0.1 1-Menthol 0.7 Carvone 0.2 Na Polyacrylate 5.0 dextranase 0.2 water balance 100.0%

Example 13 Mouse Wash 90% Ethanol 18% Polyoxyethylene (80) Sorbitan 1.8 Monotaurate Sodium Lauryl Sulfate 0.01 Erythrit 13 Cetylpyridinium Chloride 0.1 Sodium Monofluorophosphate 0.1 Triclosan 0 .02 Fragrance 0.7 l-menthol 0.3 menthon 0.1 water balance 100.0%

Example 14 Toothpaste Calcium Carbonate 80% Glycerin 10 Sodium Lauryl Sulfate 0.3 Erythrit 0.4 Saccharin Sodium 0.1 Fragrance 0.3 1-Menthol 0.5 Cineol 0.1 Water Residue 100. 0%

Example 15 Lozenges Gum Arabic 6% Glucose 15 Palatinose 36 Sodium Monofluorophosphate 0.05 Triclosan 0.02 Sodium Lauryl Sulfate 0.01 Erythrit 15 Fragrance 0.7 1-Menthol 0.3 Anethole 3 water balance 100.0%

Example 16 Dental Pasta Hydroxyethylcellulose 3.0% Carrageenan 2.0 Sorbit 20 Sucrose Palmitate Monoester 2.0 Sodium Saccharin 0.1 Aluminum Lactate 3.0 Sodium Lauryl Sulfate 0.01 Erythrit 25 Fragrance 0.2 l-menthol 0.3 eugenol 0.1 water balance 100.0%

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Makoto Maruyama 1-3-7 Honjo, Sumida-ku, Tokyo F-term in Lion Corporation (reference) 4C083 AA112 AB052 AB172 AB222 AB292 AB322 AB332 AB352 AB472 AC102 AC122 AC131 AC132 AC171 AC172 AC211 AC302 AC341 AC342 AC422 AC432 AC442 AC622 AC642 AC692 AC782 AC792 AC812 AC862 AD092 AD202 AD222 AD272 AD282 AD302 AD352 AD432 AD472 AD531 AD532 AD662 BB41 CC41 DD22 DD23 DD27 EE01 EE06

Claims (1)

[Claims] 1. A composition containing erythritol, anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol,
Thymol, cinnamaldehyde and trans-2-
An oral composition comprising one or more flavor components selected from hexenal and l-menthol in a weight ratio of 1:50 to 8: 2.