JP2001335447A - Aqueous dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an aqueous dentifrice composition having excellent stability and foaming properties while maintaining a coating effect of a hydrocarbon on teeth. SOLUTION: This aqueous dentifrice composition is characterized by comprising a hydrocarbon, a nonionic surfactant having 2-12 HLB and an anionic surfactant.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an aqueous dentifrice composition capable of preventing the adhesion of dirt by hydrophobically coating the tooth surface.

[0002]

2. Description of the Related Art The use of hydrocarbons and silicones in oral compositions as coating agents for suppressing the adhesion of dirt and bacteria to tooth surfaces has been disclosed in Japanese Patent Application Laid-Open No. 11-79962. Has been conventionally proposed as described in Japanese Patent Application Publication No.

An aqueous paste-type dentifrice is generally used for oral cleaning, and it is considered that blending a coating agent with such a dentifrice of such a type is extremely useful in considering oral hygiene. Conceivable.

[0004] However, when hydrocarbons are blended in an aqueous dentifrice composition, separation of hydrocarbons and silicones is liable to occur, a stable dosage form cannot be maintained, and foamability is reduced, resulting in a decrease in foamability. There was a problem that the feeling deteriorated. Therefore, a stable and good foaming aqueous dentifrice composition containing a hydrocarbon as a coating agent is desired.

[0005] The present invention has been made in response to the above-mentioned demands, and it is an object of the present invention to provide a water-based dentifrice composition which is excellent in stability and foamability while maintaining a tooth coating effect of hydrocarbons when used in the oral cavity. Aim.

[0006]

Means for Solving the Problems and Embodiments of the Invention As a result of intensive studies to achieve the above object, the present inventor has found that hydrocarbons have a nonionic surfactant of HLB 2 to 12 and an anionic surfactant. By using the composition in combination with the agent, it was found that an aqueous dentifrice composition excellent in stability and foaming properties was obtained while maintaining the tooth coating effect by use in the oral cavity, and the present invention was accomplished. Things.

Hereinafter, the present invention will be described in more detail. The water-based dentifrice composition of the present invention contains a hydrocarbon as a coating agent having an effect of preventing the adhesion of dirt and preventing the adhesion of bacteria, particularly by applying a hydrophobic coating to the tooth surface. In this case, the hydrocarbons used in the present invention are preferably liquid at room temperature from the viewpoint of feeling of use, and particularly preferably liquid paraffin or liquid isoparaffin. The compounding amount is 0.
1 to 5% (mass percentage, the same applies hereinafter), particularly 0.5 to 3%
Is preferred. If it is less than 0.1%, a satisfactory inhibitory effect may not be exhibited.

In the present invention, a nonionic surfactant and an anionic surfactant are used in combination with the above hydrocarbons. Here, as the nonionic surfactant, the value of HLB showing the balance between lipophilicity and hydrophilicity is 2 to 12, preferably 5 to 5.
Use 10 of them. If the HLB is beyond this range, separation may not occur or foaming may not be improved. Also,
Preferred are polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether. When other nonionic surfactants are used, separation may not occur or foaming may not be improved. The mixing ratio of the hydrocarbons and the nonionic surfactant is 1: 4 to
The ratio is preferably 4: 1, especially 1: 2 to 2: 1. Exceeding this range may not provide the expected effect.

It is to be noted that a nonionic surfactant other than the above may be blended as long as the effects of the present invention are not impaired.

On the other hand, as the anionic surfactant, alkyl sulfate, N-acylamino acid salt, N-acylmethyltaurine salt and the like can be used, and sodium lauryl sulfate and sodium lauroyl sarcosine are particularly preferable.
The compounding amount is preferably from 1: 4 to 4: 1, particularly preferably from 1: 2 to 2: 1 in terms of mass ratio to hydrocarbons, and if it exceeds this range, the expected effect may not be obtained.

The dentifrice composition of the present invention contains, in addition to the above components, an abrasive, a thickener, a binder, a sweetener, a flavor, a coloring agent,
Preservatives, various active ingredients, and the like can be added at ordinary doses.

Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate, dibasic calcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina , Magnesium carbonate, tribasic magnesium phosphate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, aluminum silicate, zirconium silicate, and a synthetic resin-based abrasive. In this case, the compounding amount is 1% of the whole composition.
It is preferable to set it to 90%, especially 10-50%.

Examples of the thickener include glycerin, sorbitol, xylitol, propylene glycol, polyethylene glycol and the like.

Examples of the binder include carrageenan, sodium alginate, propylene glycol alginate, xanthan gum, polyacrylic acid, sodium polyacrylate, carboxyvinyl polymer, tragacanth gum, guar gum, locust bean gum, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropyl Examples include cellulose, methylcellulose, gellan gum, gelatin, curdlan, gum arabic, agar, pectin, polyvinyl alcohol, polyvinylpyrrolidone, pullulan and the like.

As a sweetener, sodium saccharin,
Stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone,
And perillartin.

Examples of the flavor include terpenes such as l-menthol, carvone, anethole, limonene and the like, and derivatives thereof. Examples of the coloring agent include Blue No. 1, Yellow No. 4, Green No. 3, and titanium dioxide.

The active ingredient includes cationic bactericides such as chlorohexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride and decalinium chloride, phenolic compounds such as triclosan, hinokitiol and biosol, dextranase and mutanase. Enzymes such as lysozyme, amylase, protease, lytic enzyme and superoxide dismutase; vitamins such as vitamin E and vitamin C; alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; Sodium, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetic Phosphate, bisabolol, glycerophosphate, chlorophyll, sodium chloride, polyvinyl pyrrolidone, polyethylene glycol, water-soluble inorganic phosphoric acid compounds and the like, can be blended these known active ingredients one or more.

[0018]

Industrial Applicability The aqueous dentifrice composition of the present invention is excellent in stability and foamability while maintaining the tooth coating effect of hydrocarbons.

[0019]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

Example 1, Comparative Examples 1-4 An aqueous dentifrice composition having the composition shown in Table 1 was prepared.

[0021]

[Table 1] * HCO-10, HCO-60: Nikko Chemicals

Next, the tooth surface coating effect, separation stability and foaming of the above composition were evaluated by the following methods. Table 2 shows the results. Experiment-1: Tooth surface coating effect A sterilized apatite pellet was treated with dentifrice diluted three-fold with sterile water, washed three times with sterile water, and BHI containing the pellet and 1% sucrose, and pre-cultured. S. mutans bacteria in a sterile petri dish,
Incubate for 4 hours. Thereafter, the pellets are washed three times with water,
The plaque staining solution was applied and washed again with water, and the degree of coloring was visually compared with untreated apatite pellets and evaluated as follows. 5: No coloring 4: Little coloring 3: Clearly less coloring than untreated 2: Slightly less coloring than untreated 1: Coloring equivalent to untreated

Experiment-2: Separation stability The dentifrice was stored in a constant temperature bath at 50 ° C. for 2 weeks, and the state when removed from the container was evaluated as follows. ◎: No separation ○: Almost no separation △: Slight separation is observed ×: Clear separation is observed

Experiment-3: Foaming 1 g of toothpaste and 5 ml of water were put into a 100 ml Nesler tube.
Shaking vigorously, the height of foaming after 3 minutes was read on the scale of a Nesler tube, and evaluated as follows by comparison with a control (the toothpaste of Comparative Example 4). ◎: equal to or more than the control example ○: slightly less than the control example △: clearly less than the control example ×: almost no foam

[0025]

[Table 2]

Example 2 POE (10) Hardened Castor Oil (HLB 6.5) 1% Liquid Paraffin 1 Sodium Lauryl Sulfate 2 Calcium Phosphate Dihydrate 40 Propylene Glycol 3 Sorbite 30 Sodium Alginate 0.3 Sodium Carboxymethyl Cellulose 0.8 Dextranase 0.2 Sodium monofluorophosphate 0.76 Triclosan 0.02 Paraoxybenzoate 0.1 Saccharin sodium 0.2 Green No. 3 Trace amount of perfume 1 Water Residual 100.0% Experiment-1 Experiment-3 Experiment-3 ○

Example 3 POE (5) Hardened Castor Oil (HLB 6.0) 0.8% Liquid Isoparaffin 0.5 Sodium Lauryl Sulfate 1.3 Sarcosinate 0.2 Calcium Carbonate 50 Xylitol 1 Polyethylene Glycol 400 3 Glycerin 20 Sodium polyacrylate 0.5 Sodium carboxymethylcellulose 0.5 Dextranase 0.2 Sodium monofluorophosphate 0.76 Triclosan 0.02 Paraoxybenzoate 0.1 Saccharin sodium 0.2 Titanium dioxide 0.3 Blue No. 1 Trace amount of fragrance 1 water balance 100.0% Experiment-1 3 Experiment-2 ○ Experiment-3 ○

Example 4 POE (7.5) Hydrogenated Castor Oil (HLB 6.0) 2% Liquid Paraffin 2 Sodium Lauryl Sulfate 1.5 Thickening Silica 5 Silica 15 Xylitol 5 Propylene Glycol 3 Glycerin 20 Sorbit 30 Polyacryl Sodium citrate 0.8 Xanthan gum 0.7 Sodium fluoride 0.21 Tranexamic acid 0.05 Triclosan 0.02 Paraoxybenzoate 0.1 Saccharin sodium 0.2 Titanium dioxide 0.3 Green No. 3 Trace amount of perfume 1 Water Balance 100 0.0% Experiment-1 4 Experiment-2 ○ Experiment-3 ○

Example 5 POE (7) Cetyl Ether (HLB9) 0.7% Liquid Isoparaffin 1 Sodium Lauryl Sulfate 1.4 Thickening Silica 5 Calcium Phosphate Dihydrate 40 Propylene Glycol 3 Sorbite 25 Sodium Alginate 0.6 Xanthan Gum 0.7 Dextranase 0.2 Sodium monofluorophosphate 0.76 Triclosan 0.02 Paraoxybenzoate 0.1 Saccharin sodium 0.2 Fragrance 1 Water Balance 100.0% Experiment-1 Experiment-4 Experiment -3 ○

[Example] 6 POE (5) lauryl ether (HLB9) 1% liquid paraffin 1.5 sodium lauryl sulfate 2 thickening silica 5 calcium phosphate dihydrate 40 polyethylene glycol 400 3 glycerin 20 carrageenan 0.4 carboxymethyl cellulose Sodium 0.8 Dextranase 0.2 Sodium monofluorophosphate 0.76 Paraoxybenzoate 0.1 Saccharin sodium 0.2 Fragrance 1 Water Balance 100.0% Experiment-1 Experiment-4 ○ Experiment-3 ○

Example 7 POE (7) Lauryl Ether (HLB10) 1.3% Liquid Paraffin 0.7 Sodium Lauryl Sulfate 1.2 Sarcosinate 0.1 Silica 15 Propylene Glycol 3 Glycerin 20 Sorbit 30 Sodium Polyacrylate 0 8.8 Xanthan gum 0.7 Sodium fluoride 0.21 Tranexamic acid 0.05 Triclosan 0.02 Paraoxybenzoic acid ester 0.1 Saccharin sodium 0.2 Green No. 3 Trace yellow 4 Trace perfume 1 water Residue 100.0% Experiment -1 3 Experiment-2 ◎ Experiment-3 ○ Polyoxyethylene hydrogenated castor oil: Nikko Chemicals, Inc. Polyoxyethylene alkyl ether: Nippon Emulsion

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Claims (3)

[Claims] An aqueous dentifrice composition comprising a hydrocarbon, a nonionic surfactant having an HLB of 2 to 12, and an anionic surfactant. 2. The aqueous dentifrice composition according to claim 1, wherein the hydrocarbon is liquid paraffin or liquid isoparaffin. 3. The aqueous dentifrice composition according to claim 1, wherein the nonionic surfactant having an HLB of 2 to 12 is polyoxyethylene hydrogenated castor oil or polyoxyethylene alkyl ether.