JPH10120538A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a liquid composition for the oral cavity, with formation of precipitated controlled when preserved at high temperature for extended periods, good in survival rate of dextranase, and excellent in temporal stability and appearance. SOLUTION: The composition contains dextrabase but no abrasive, and is incorporated with at least one type of water-soluble high-molecular-weight compound selected from the group consisting of an alkali metal salt of carboxymethyl cellulose having a degree of etherification of 1 or lower and degree of polymerization of 700 or lower, κ-carrageenan, ι-car, ageenan and hydroxyethyl cellulose.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid oral composition such as a mouthwash containing no dextranase and containing no abrasive, and more specifically, has a high storage stability of dextranase. The generation of precipitates due to high temperature storage is suppressed,
The present invention relates to a dextranase-containing liquid oral composition that retains a good appearance over a long period of time.

[0002]

2. Description of the Related Art
Although a mouthwash containing dextranase and containing no abrasive is known, a conventional mouthwash of this type forms a precipitate when stored at high temperatures, and sometimes has a problem in appearance stability.

The present inventors have conducted various studies on the mechanism of the formation of such precipitates. As a result, it was found that these precipitates are impurities generated due to inactivation of a part of dextranase in the mouthwash. It was also found that when the impurities exceeded the allowable range of the solubilizing power of the surfactant, they formed as precipitates.

[0004] Accordingly, the formation of such precipitates not only reduces the appearance but also reduces the effectiveness of dextranase, so that inactivation of dextranase is prevented as much as possible. Liquid oral compositions such as mouthwashes having high appearance stability have been desired.

SUMMARY OF THE INVENTION The present invention has been made to meet the above-mentioned demand, and suppresses the generation of precipitates generated by high-temperature storage, prevents cloudiness for a long period of time, and maintains a good appearance. An object of the present invention is to provide a composition for a liquid oral cavity which is free of an abrasive and in which deactivation is prevented as much as possible.

[0006]

Means for Solving the Problems and Embodiments of the Invention As a result of intensive studies to achieve the above object, the present inventor has found that the formation of the precipitate is caused by the inactivation of a part of dextranase. It was thought that the resulting aggregates of impurities would form precipitates that were visually observed due to the formation of aggregates of the impurities. Therefore, the inventors focused on a water-soluble polymer substance as an agent showing an effect of suppressing the formation of the aggregates of the impurities. Then, an alkali metal salt of carboxymethylcellulose having a degree of etherification of 1 or less and a degree of polymerization of 700 or less as a water-soluble polymer substance, kappa (κ) is added to a liquid oral composition containing dextranase and containing no abrasive. As a result of adding carrageenan, iota carrageenan or hydroxyethylcellulose, the generation of precipitates is suppressed even after long-term storage at high temperature, and the inactivation of dextranase is prevented. The present inventors have found that a particularly effective effect can be attained by incorporating a polymer substance in an amount of 0.01 to 0.3% by weight of the whole composition, and have accomplished the present invention.

[0007] Accordingly, the present invention provides an oral composition containing dextranase and containing no abrasive, having a degree of etherification of 1%.
A high-temperature storage characterized by comprising one or more water-soluble polymer substances selected from the group consisting of alkali metal salts of carboxymethyl cellulose having a degree of polymerization of 700 or less, kappa carrageenan, iota carrageenan and hydroxyethyl cellulose. Provided is a liquid oral composition capable of maintaining good appearance stability even under a liquid.

Hereinafter, the present invention will be described in more detail. The liquid oral composition of the present invention is prepared as a mouthwash, a dental rinse, etc., and comprises dextranase,
A specific water-soluble polymer substance is an essential component.
In this case, the liquid oral composition of the present invention does not contain an abrasive.

The dextranase is not particularly limited, but those derived from the genus Ketomium, Streptomyces, Bacillus, Corynebacterium and the like are suitable. The amount of dextranase is 100-100,000 units per ml of the composition, especially 500
It is preferable to use 50,000 units. The above one unit is 1 unit when dextran is used as a substrate.
This is a value in which the amount of reducing sugar generated per minute is expressed in terms of μg of glucose.

As the water-soluble polymer substance, alkali metal salts of carboxymethyl cellulose such as sodium carboxymethyl cellulose, carrageenan, and hydroxyethyl cellulose are used. In this case, the alkali metal salt of carboxymethyl cellulose has a degree of etherification of 1 or less and a degree of polymerization of 700 or less, particularly a degree of etherification of 0.6 to 0.95 and a degree of polymerization of 150.
650 is used. When the degree of etherification exceeds 1, or when the degree of polymerization exceeds 700, turbidity occurs, and a favorable composition cannot be obtained from the viewpoint of appearance.

As the carrageenan, copper (κ) carrageenan and iota carrageenan are used, but copper carrageenan is preferable. These water-soluble polymer substances can be used alone or in combination of two or more.

The compounding amount of the water-soluble polymer substance is 0.01 to 0.3% by weight, particularly 0.05 to 0.2% by weight in total.
Is preferable. 40 ° C if less than 0.01% by weight
Precipitation may occur within 6 months in the storage test under the conditions, and when it exceeds 0.3% by weight, a problem may occur in taste.

The composition for liquid oral cavity of the present invention can be prepared into dosage forms such as mouthwash, mouthwash, diluted mouthwash, etc. In addition to the above essential components, various compositions for each purpose can be prepared. Known components can be blended.

Specifically, in the present invention, in addition to dextranase, enzymes such as amylase, protease, mutanase, and lysozyme, sodium fluoride, sodium monofluorophosphate, triclosan, chlorhexidine, tranexamic acid, and the like are used as active ingredients. One or more kinds such as cetylpyridinium chloride may be blended.

As a surfactant, sucrose fatty acid esters having a fatty acid group having 12 to 18 carbon atoms such as sucrose mono- and dilaurate, fatty acid glycerides such as stearic acid monoglyceride, and ethylene oxide having an average degree of polymerization of 10 to 10 are used. 100 moles of polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, ester-based nonionic surfactant such as polyoxyethylene hydrogenated castor oil having an average degree of polymerization of 10 to 100 moles of ethylene oxide, and ethylene oxide having an average degree of polymerization of 6 Polyoxyethylene alkyl ethers, polyoxyethylene alkyl aryl ethers, polyoxyethylene alkyl phenyl ethers, and the average degree of polymerization of ethylene oxide is 20 to 50 mol.
Up to 70 mol of a block polymer type ether-based nonionic surfactant such as polyoxyethylene polyoxypropylene ether and polyoxyethylene polyoxypropylene alkyl ether can be used alone or in combination. It can be used as 0.5 to 3% by weight.

As the thickener, propylene glycol,
One or more of glycerin and sorbit can be used in a total amount of 0.3 to 2.0% by weight, preferably 0.5 to 1.0% by weight.

Further, sweeteners such as saccharin, dipotassium glycyrrhizinate, stevia extract, aspartame, paramethoxycinnamic aldehyde, neohesperidyl dihydroxychalcone, and perilla lactin, sodium benzoate, paraoxybenzoate, lower fatty acid monoglyceride, p Preservatives such as -hydroxymethylbenzoic acid and p-hydroxyethylbenzoic acid can be used.

As the buffer, phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid and carbonic acid and their potassium salts, sodium salts and ammonium salts, amino acids and their salts, ribonucleic acid And salts thereof, and one or more of sodium hydroxide, borax, bicarbonate hydrochloride, and the like. Among these, it is particularly preferable to use a neutral amino acid or a salt thereof. Here, glycine,
Alanine, serine and leucine are mentioned, and acidic amino acids include aspartic acid, glutamic acid and asparagine glutamine.

As the flavor, one or more of menthol, eugenol, anethole, citronellol, limonene, citronellyl acetate, cineol, spearmint oil, peppermint oil, lemon oil, orange oil, rosemary oil and the like can be used. .

The liquid oral composition of the present invention is usually adjusted to pH 5-9.

Any of the above components can be blended within a range that does not impair the effects of the present invention. PE container
T (polyethylene terephthalate), glass and the like can be used, but not limited thereto, and polypropylene and the like can also be used.

[0022]

EFFECTS OF THE INVENTION The liquid oral composition of the present invention suppresses the generation of precipitates during long-term storage at high temperatures, has a good residual ratio of dextranase, and has good stability over time and product appearance. Are better.

[0023]

EXAMPLES The present invention will now be described specifically with reference to experimental examples and examples, but the present invention is not limited to the following examples. In the following examples, all percentages are by weight.

The evaluation criteria are as shown below. Evaluation method of appearance stability (sediment) 80 ml of mouthwash was placed in a 100 ml plastic bottle,
It was kept standing in a constant temperature bath at 40 ° C., and the appearance after three months was visually determined according to the following criteria. Evaluation criteria ：: No precipitate is observed. Δ: Slight formation of precipitate is observed. ×: Formation of a precipitate is observed. Evaluation method of residual ratio of dextranase Put 80 ml of mouthwash into a 100 ml plastic bottle,
The mouthwash which was left standing for 3 months in a 40 ° C. constant temperature bath was used as a sample solution, and 1 g of each sample solution was collected.
After diluting 100-fold with a phosphate buffer of 0, using dextran as a substrate, and reacting at 40 ° C. for 10 minutes, the titer was measured based on the ability to form free reducing sugars, and the titer of each sample was measured. The residual ratio was evaluated by the ratio to the initial value. Evaluation criteria ：: Residual rate where the amount of dextranase is 70% or more of the initial value. Δ: The amount of dextranase exceeds 30% of the initial value and is 70.
% Residual rate. ×: Residual rate where the amount of dextranase is 30% or less of the initial value. Evaluation method of turbidity (white turbidity) Put 80 ml of mouthwash into a 100 ml plastic bottle,
Store in a constant temperature bath at 40 ° C and turn cloudy (cloudy) after 3 months
Was determined based on the following criteria. Evaluation criteria ：: Turbidity is not observed at all. Δ: Turbidity is slightly generated. X: Turbidity occurs.

[Experimental Example 1] A mouthwash having the composition shown in Table 1 was prepared by a conventional method and stored in a thermostat at 40 ° C for 3 months.
Evaluation was performed based on the above criteria. Table 1 shows the results.

The degree of etherification of carboxymethyl cellulose is 1.0 and the degree of polymerization is 700.

[0027]

[Table 1]

From the results shown in Table 1, the appearance stability of the mouthwash and the stability of dextranase can be obtained by blending carboxymethylcellulose and kappa (κ) carrageenan as water-soluble polymers in the mouthwash containing dextranase. It was found that excellent evaluation was obtained in terms of the properties and the cloudiness of the whole liquid. In addition, iota carrageenan had the same effect.

Experimental Example 2 Mouthwashes having the compositions shown in Table 2 were prepared and evaluated according to the above evaluation criteria. Table 2 shows the results.

[0030]

[Table 2]

From the results in Table 2, it can be seen that the use of sodium carboxymethylcellulose having a degree of etherification of 1 or less and a degree of polymerization of 700 or less in a mouthwash containing dextranase and a water-soluble polymer substance is excellent. Evaluation was obtained.

Experimental Example 3 Mouthwashes having the compositions shown in Table 3 were prepared and evaluated according to the above evaluation criteria. Table 3 shows the results.

[0033]

[Table 3]

From the results shown in Table 3, it was found that excellent evaluation can be obtained by adding a water-soluble polymer substance in the range of 0.01 to 0.3% in the mouthwash of the present invention.

Example 1 Mouthwash Ethanol 10.0% Glycerin (85%) 10.0 Citric Acid 3.0 Sodium Citrate 6.0 Xylit 3.0 Sodium Fluoride 0.2 Sodium Saccharin 0.1 Benzo Sodium acid 0.2 Dye 0.0002 Fragrance 0.2 Dextranase 0.1 Polyoxyethylene (20) stearyl ether 0.4 Propylene glycol 3.0 Sodium carboxymethyl cellulose (Degree of etherification 1.0; Degree of polymerization 700) 0.2 Purified water balance meter 100.0%

Example 2 Mouthwash Ethanol 1.0% Glycerin (85%) 7.5 Citric acid 2.5 Sodium citrate 5.0 Dipotassium glycyrrhizinate 0.05 Tranexamic acid 0.05 Stevia extract 0.0 1 fragrance 0.3 dextranase 0.5 polyoxyethylene (200) polyoxypropylene (70) 1.2 propylene glycol 3.0 copper (κ) carrageenan 0.025 iota carrageenan 0.025 purified water balance meter 100. 0%

Example 3 Mouthwash Ethanol 10.0% Glycerin (85%) 10.0 Sodium Monohydrogen Phosphate 3.0 Sodium Dihydrogen Phosphate 6.0 Xylit 3.0 Sodium Bicarbonate 3.0 Saccharin sodium 0.1 Sodium benzoate 0.2 Fragrance 0.2 Dye 0.0002 Dextranase 0.5 Polyoxyethylene (20) cetyl ether 1.0 Propylene glycol 3.0 Hydroxyethyl cellulose 0.2 Purified water Balance meter 100 0.0%

Example 4 Mouthwash Ethanol 1.0% Sorbit (60%) 7.5 Citric Acid 2.5 Sodium Dihydrogen Phosphate 2.5 Triclosan 0.1 Stevia Extract 0.1 Perfume 0.3 Dextranase 0.5 Polyoxyethylene (60) hydrogenated castor oil 1.0 Propylene glycol 3.0 Iota carrageenan 0.2 Purified water Balance meter 100.0%

Example 5 Mouthwash Ethanol 1.0% Sorbit (60%) 7.5 Citric Acid 2.5 Sodium Dihydrogen Phosphate 2.5 Triclosan 0.1 Stevia Extract 0.1 Perfume 0.3 Dextranase 0.5 Polyoxyethylene (60) hydrogenated castor oil 1.0 Propylene glycol 3.0 Iota carrageenan 0.2 Cetylpyridinium chloride 0.05 Purified water Balance meter 100.0%

Example 6 Mouthwash Ethanol 1.0% Sorbit (60%) 7.5 Citric Acid 2.5 Sodium Dihydrogen Phosphate 2.5 Triclosan 0.1 Stevia Extract 0.1 Fragrance 0.3 Dextranase 0.5 Polyoxyethylene (60) hydrogenated castor oil 1.0 Propylene glycol 3.0 Iota carrageenan 0.2 Chlorhexidine gluconate 0.05 Purified water Balance meter 100.0%

Claims (1)

[Claims] 1. An oral composition containing dextranase and containing no abrasive is added to an alkali metal salt of carboxymethylcellulose having a degree of etherification of 1 or less and a degree of polymerization of 700 or less, kappa carrageenan, iota carrageenan and hydroxy. A composition for a liquid oral cavity comprising one or more water-soluble polymer substances selected from ethyl cellulose.