JP2009096748A - Liquid composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid composition for oral cavity, which is excellent in saliva secretion-accelerating effect originated from γ-polyglutamic acid or its salt, excellent in moist feeling after use, has good appearance stability in preservation at a room temperature or at a low temperature, and has low irritation. <P>SOLUTION: This liquid composition for oral cavity comprises (A) an N-acylsarcosine sodium, (B) a polyoxyethylene-hardened castor oil having 40 to 100 moles mean addition mole number of ethylene oxide, formulated with a liquid composition for the oral cavity containing γ-polyglutamic acid or its salt, and without substantially blending ethanol. The liquid composition for oral cavity preferably further comprises (C) carboxymethyl cellulose sodium. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention has an excellent salivary secretion promoting effect, good appearance stability after storage at room temperature or low temperature, little irritation during use or after use, excellent moist feeling, substantially free of ethanol, The present invention relates to a liquid oral composition containing γ-polyglutamic acid or a salt thereof effective for oral care for dry mouth symptoms.

  There are various causes of dryness in the mouth, but stress due to mental tension, taking drugs that cause dry mouth, lifestyle-related diseases such as diabetes and hypertension, kidney disease, and even collagen disease It has become clear that a systemic disease called Sjogren's syndrome is involved.

  Dryness in the mouth is accompanied by discomfort due to sticky stickiness, difficulty in drinking food, difficulty in conversation, generation of bad breath, increased plaque, and the like. Further morbidity results in changes in the oral flora, resulting in oral troubles with impaired oral function, such as caries, periodontal disease, mucosal infection, and the like. Therefore, moisturizing the oral cavity is important for keeping the oral cavity refreshing and preventing oral diseases.

  As a means for moisturizing the oral cavity, there is a use of a moisturizing agent having a water retaining ability. For example, International Publication No. 00/56344 pamphlet (Patent Document 1) proposes the use of hyaluronic acid which is a moisturizing agent.

  On the other hand, it has also been proposed to actively promote saliva secretion to moisturize the oral cavity. For example, Japanese Laid-Open Patent Publication No. 56-22719 (Patent Document 2) discloses plum pickles and ume vinegar, Japanese Laid-Open Patent Publication No. 7-101856. Have proposed the use of organic acids as salivary secretion promoters. Except for saliva secretion by sourness stimulation, Japanese cypress seeds are disclosed in Japanese Patent Laid-Open No. 10-182392 (Patent Document 3), Japanese cypress seeds are disclosed in Japanese Patent Laid-Open No. 2002-265375 (Patent Document 4). It has been proposed to use plant azalea as a salivary secretion promoter.

  However, although a moisturizing agent such as hyaluronic acid has a moisturizing effect, it does not positively promote salivary secretion, and its effect is limited. Further, the saliva secretion promoter described above has a problem that its use is limited because it has a certain taste.

  On the other hand, γ-polyglutamic acid or a salt thereof is a tasteless and odorless moisturizer, but in recent years, an effect of promoting salivary secretion has been confirmed, and it has been attracting attention as one that moisturizes the oral cavity more effectively than conventional moisturizers. A blended oral composition has been proposed in International Publication No. 05/049050 (Patent Document 5). Further, JP 2005-255645 A (Patent Document 6) has been proposed to have an effect of promoting remineralization of teeth and to be blended into a pharmaceutical composition.

  However, an aqueous solution of γ-polyglutamic acid or a salt thereof becomes turbid or cloudy over time when stored at room temperature. Therefore, a liquid composition containing γ-polyglutamic acid or a salt thereof has poor appearance stability, and γ- There existed a subject that the effect derived from polyglutamic acid or its salt was not exhibited satisfactorily.

  Further, as a liquid oral composition containing γ-polyglutamic acid or a salt thereof, a mouthwash containing 20% by mass of ethanol as a solvent, or a composition containing 50% by mass or more of polyhydric alcohol is disclosed in Patent Document 5, 6. If ethanol is blended in this way or polyalcohol is blended at a high concentration, even if it is blended with γ-polyglutamic acid or a salt thereof, it is difficult to cause orientation and white turbidity. There is a problem that it is easy to dry because it contains highly irritating and highly volatile ethanol. In addition, those containing a high concentration of polyhydric alcohol have a low water content and a high viscosity of the composition, which is not suitable for mouthwashing, and also has a disadvantage that sweetness derived from polyhydric alcohol is strong and inferior in palatability. there were.

  Accordingly, there is a demand for a liquid oral composition that can stably incorporate γ-polyglutamic acid or a salt thereof, has excellent appearance stability, exhibits its effects sufficiently, and has a good feeling in use.

International Publication No. 00/56344 Pamphlet JP-A-56-22719 Japanese Patent Laid-Open No. 7-101856 JP 2002-265375 A International Publication No. 05/049050 Pamphlet JP 2005-255645 A

  The present invention has been made in view of the above circumstances, is excellent in salivary secretion promoting effect derived from γ-polyglutamic acid or a salt thereof, excellent in moist feeling after use, good in appearance stability at room temperature or low temperature storage, low It is an object of the present invention to provide a liquid oral composition that is stimulating and substantially free of ethanol.

  As a result of intensive studies to achieve the above object, the inventors of the present invention have added a liquid oral composition containing γ-polyglutamic acid or a salt thereof to an average addition mole number of sodium N-acyl sarcosine and ethylene oxide. Is blended with 40 to 100 moles of polyoxyethylene hydrogenated castor oil, and the composition does not substantially contain ethanol, whereby γ-polyglutamic acid or a salt thereof can be stably blended, and γ-polyglutamic acid or The salt-derived saliva secretion-promoting effect is satisfactorily exhibited, and the appearance stability is good even after long-term storage at room temperature (25 ° C) or low temperature (-5 ° C). In addition, by adding sodium carboxymethyl cellulose, the moist feeling after use and the appearance stability are further improved. It was heading.

  According to the present invention, by blending the above-mentioned specific components in combination, it is possible to stably blend γ-polyglutamic acid or a salt thereof with a composition substantially free of ethanol, and has an excellent salivary secretion promoting effect, In addition, a high-quality liquid oral composition that has good storage stability at room temperature or low temperature, has a moist feeling after use, has a low irritation and good usability, and is excellent in preventing and improving dry mouth disease. It has been found that it is obtained, and has led to the present invention.

Therefore, the present invention provides a liquid oral composition containing γ-polyglutamic acid or a salt thereof,
(A) N-acyl sarcosine sodium,
(B) A composition for liquid oral cavity characterized by blending polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 40 to 100 moles and substantially not containing ethanol, and (C) carboxy The liquid oral composition described above is characterized by containing sodium methylcellulose.

  The composition for liquid oral cavity of the present invention is excellent in saliva secretion promoting effect, excellent in moist feeling after use, has good appearance stability even after long-term storage at room temperature or low temperature, and has a good feeling of use with low irritation. It is effective for the prevention or improvement of xerostomia.

  Hereinafter, the present invention will be described in more detail. The liquid oral composition of the present invention contains γ-polyglutamic acid or a salt thereof, and (A) N-acyl sarcosine sodium and (B) an average addition mole of ethylene oxide. It contains 40 to 100 moles of polyoxyethylene hydrogenated castor oil and is substantially free of ethanol.

  The γ-polyglutamic acid or a salt thereof used in the present invention is used as a moisturizing component and a salivary secretion promoting component, specifically, γ-polyglutamic acid synthesized by a chemically known method, or Natural γ-polyglutamic acid obtained as a fermentation product from various γ-polyglutamic acid-producing strains such as Bacillus natto and salts thereof can be used, and commercially available products may be used. Among these, natural γ-polyglutamic acid or a salt thereof is preferable because it is blended in an oral composition, and γ-polyglutamic acid or a salt thereof that can be industrially mass-produced is most preferable. The γ-polyglutamic acid may be D-form or L-form, and D-form and L-form may be mixed.

  γ-polyglutamic acid is insoluble in water, but becomes water-soluble when converted to a salt. In this case, examples of the salt include alkali metal or alkaline earth metal salt such as sodium salt, potassium salt, magnesium salt, calcium salt, ammonium salt, ethanolamine salt, basic amino acid salt, etc. There is no particular limitation as long as it can be used. In addition, the neutralization degree of the salt can be arbitrarily selected according to the purpose in the range of pH 1 to pH 14 of the 1% by mass aqueous solution.

  As γ-polyglutamic acid or a salt thereof, sodium γ-polyglutamate represented by the following formula (1) is particularly preferable.

（但し、式中、ｎ＝６６〜３３１１２、好ましくは３３１〜１３２４５の整数。）

(However, in the formula, n = 66 to 33112, preferably an integer of 331 to 13245.)

  The viscosity of γ-polyglutamic acid or a salt thereof is not particularly limited, but the viscosity of a 4% aqueous solution obtained by the method described later is preferably in the range of 40 to 200 mPa · s, particularly 60 to 120 mPa · s. Depending on the viscosity, various viscosities can be used.

Viscosity Measurement Method Take 96 g of water in a 200 mL beaker and add 4.0 g of γ-polyglutamic acid or a salt thereof to the beaker with stirring with a stirrer to completely dissolve it. Next, after leaving still in a 25 degreeC thermostat for 1 hour, the viscosity after 1 minute is measured correctly using a BL type | mold viscometer.
BL type viscometer: Tokyo Keiki B type viscometer Model BL
Rotor: No. 2
Rotation speed: 60rpm
Measurement temperature: 25 ° C

  The blending amount of γ-polyglutamic acid or a salt thereof is preferably 0.05 to 2% (mass%, the same applies hereinafter), particularly 0.1 to 1%, based on the entire composition. If the amount is too small, the moist feeling after use and the effect of promoting salivation may not be exhibited. If the amount is too large, the viscosity increases, which may affect the feeling in use.

  The component (A) N-acyl sarcosine sodium is preferably one having a carbon chain length of 12 to 16 in terms of taste, specifically lauroyl sarcosine sodium, myristoyl sarcosine sodium, palmitoyl sarcosine sodium, and particularly lauroyl sarcosine sodium. Is preferred.

  The blending amount of N-acyl sarcosine sodium is preferably 0.05 to 1.0%, more preferably 0.1 to 0.5% in the composition from the viewpoint of appearance stability at room temperature and low temperature. If the blending amount is less than 0.05%, the orientation may be generated or become cloudy and the appearance stability at room temperature may be impaired. If the blending amount exceeds 1.0%, it may precipitate over time or cause irritation during low-temperature storage. The taste may be worse.

  The polyoxyethylene hydrogenated castor oil of component (B) has an average addition mole number of ethylene oxide of 40 to 100 mol from the viewpoint of appearance stability and taste at low temperature, and preferably from the viewpoint of appearance stability at low temperature. 60-100 moles are used. When the average added mole number of ethylene oxide is less than 40 moles, orientation and scratches are generated at room temperature or low temperature storage, and those exceeding 100 moles are generally not commercially available.

  The blending amount of the polyoxyethylene hydrogenated castor oil is preferably 0.1 to 1.0%, more preferably 0.2 to 0.7% in terms of appearance stability at low temperatures. If it is less than 0.1%, it is difficult to maintain the appearance stability, and if it exceeds 1.0%, a bitter taste derived from polyoxyethylene hydrogenated castor oil may be produced or the taste may be deteriorated.

  Furthermore, (C) sodium carboxymethylcellulose can be mix | blended with the liquid oral cavity composition of this invention in order to improve the external appearance stability in room temperature and low temperature, and the moist feeling after use. As sodium carboxymethylcellulose, those having a degree of etherification of 2.0 to 2.8, particularly 2.2 to 2.6 are preferred.

Here, the degree of etherification is determined according to the CMC Industrial Association analysis method (ashing method). About 1 g (absolutely dry weight) of powder sample is precisely weighed, wrapped in filter paper and placed in a magnetic crucible. After ashing, the produced sodium hydroxide was neutralized and titrated with 0.1N sulfuric acid using phenolphthalein as an indicator, and calculated according to the following formula.
Degree of etherification = 162 × A / (1000-80 × A)
Here, A is a value obtained by correcting the mL number of 0.1 N sulfuric acid required for titration by the titer.

  The amount of sodium carboxymethylcellulose is preferably 0.05 to 1.0%, particularly 0.1 to 0.5% of the entire composition. If it is less than 0.05%, the effect of improving the appearance stability is poor, and if it exceeds 1.0%, the stickiness after use becomes high and the usability may be deteriorated.

  The liquid oral composition of the present invention is a liquid oral composition substantially free of ethanol. Here, in the composition for liquid oral cavity, there is a case where a small amount of raw material-derived ethanol is contained in the blended fragrance, etc., and in consideration of these reasons, “substantially free of ethanol” described here is considered. Means that the amount of ethanol in the composition is 100 ppm or less, preferably 50 ppm or less, particularly preferably 10 ppm or less of the whole composition, and may be 0 ppm.

  The composition for liquid oral cavity of the present invention can be prepared and applied as a mouthwash, liquid dentifrice, and the like, and in addition to the above essential components, an appropriate optional component can be blended depending on the dosage form. For example, wetting agents, thickeners, pH adjusters, preservatives, sweeteners, fragrances, surfactants, active ingredients, colorants and the like can be included.

  Examples of the wetting agent include polyhydric alcohols such as glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, maltitol, and erythritol. Note that the liquid oral composition of the present invention contains a high concentration of polyhydric alcohol, so that the composition becomes highly viscous, or the sweetness and bitterness derived from polyhydric alcohol is strong and inferior in palatability. When blending a monohydric alcohol, the blending amount is desirably 30% or less, particularly 1 to 15% of the entire composition.

  As a thickener, in addition to sodium carboxymethylcellulose, other thickeners can be used as long as the effects of the present invention are not hindered. For example, xanthan gum, sodium alginate, polyvinyl alcohol, hydroxyethyl cellulose, carrageenan and the like can be blended. The blending amount is preferably 0.01 to 1.0% in the composition.

Examples of pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid and salts thereof such as potassium salt, sodium salt, ammonium salt, ribonucleic acid or salts thereof, and One type or two or more types such as sodium hydroxide can be used, and a combination of phosphoric acid and its sodium salt, and citric acid and its sodium salt are particularly preferable.
The liquid oral composition of the present invention preferably has a pH at 25 ° C. adjusted to 5.5 to 7.5, and sodium dihydrogen phosphate and sodium monohydrogen phosphate or citric acid as a pH adjuster in the vicinity thereof. A combination of sodium citrate and sodium citrate is preferably used.

Examples of the preservative include sodium benzoate, methylparaben, ethylparaben, propylparaben, butylparaben, cetylpyridinium hydrochloride, alkyldiaminoethylglycine hydrochloride, potassium sorbate and the like.
Examples of the sweetening agent include saccharin sodium, steviosite, sucralose, reduced palatinose, erythritol, trehalose and the like.

Natural flavors such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, etc. Essential oils and flavor components contained in the above natural essential oils such as l-carvone, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spirantol, etc. Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol Perfume ingredients such as ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-1-menthyl carbonate, A combination of flavoring ingredients and natural essential oils (without ethanol), including flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt 1 type or 2 or more types can be mentioned.
The compounding quantity of a fragrance | flavor is 0.00001 to 3% in the composition of this invention, and it can be used in the range which does not prevent the effect of this invention so that ethanol may not be substantially contained in a composition.

  As the surfactant, in addition to the above-mentioned sodium N-acyl sarcosine and polyoxyethylene hydrogenated castor oil, other surfactants may be blended within a range not impeding the effects of the present invention. Specifically, anionic surfactants such as lauroylmethyl taurine, sodium dodecylbenzenesulfonate, α-sulfo fatty acid alkyl ester / sodium, alkyl phosphate ester salt, alkyldimethylaminoacetic acid betaine, fatty acid amidopropyldimethylaminoacetic acid betaine Acetate-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts and other imidazoline-type amphoteric surfactants, and N-fatty acid acyl-L-alginate salt and other amino acid-type surfactants A nonionic surfactant such as an agent and polyoxyethylene alkyl ether can be used alone or in combination of two or more. The blending amount of the other surfactant is preferably 0.01 to 5% in the composition.

  As active ingredients, fungicides such as triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, anti-inflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, dextranase, amylase, protease, mutanase, Enzymes such as lysozyme, lytic enzyme, lytechenzyme, fluorides such as sodium fluoride, sodium monofluorophosphate, stannous fluoride, vitamin C such as aluminum chlorohydroxy allantoin, allantoin, azulene, lysozyme chloride, ascorbic acid , Dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acids, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, ogon, clove, hamamelis, etc. Extract, copper gluconate, Karopeputaido, sodium polyphosphate, water-soluble inorganic phosphoric acid compounds, polyvinylpyrrolidone, anti-tartar agents, anti-plaque agents, potassium nitrate, may be added to aluminum lactate and the like. In addition, the compounding quantity of these active ingredients can be contained in the range which does not disturb the effect of this invention.

  As a colorant, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105 can be added.

  As the container for storing the liquid oral composition, PET (polyethylene terephthalate), glass, polypropylene, and polyethylene can be used, but use of PET and glass is preferable from the viewpoint of suppression of perfume adsorption.

  EXAMPLES Hereinafter, although an experimental example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified,% means mass%.

  In addition, for preparation of the following liquid oral composition, sodium γ-polyglutamate (manufactured by Meiji Food Materia Co., Ltd., 4% viscosity 40.mPa · s, 84.5mPa · s, 189mPa · s), lauroyl sarcosine sodium ( Kawaken Fine Chemicals), Myristoyl Sarcosine Sodium (Nikko Chemicals), Polyoxyethylene (40) hydrogenated castor oil (Nikko Chemicals), Polyoxyethylene (60) hydrogenated castor oil (Nikko Chemicals), Poly Oxyethylene (100) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd.), sodium carboxymethylcellulose (Ernest Gum, manufactured by Daicel Chemical Industries, degree of etherification 2.3), citric acid (manufactured by Fuso Chemical Co., Ltd.), sodium citrate (Fulso Chemical) Used). As comparative components, sodium lauryl sulfate (manufactured by Toho Chemical Co., Ltd.), polyoxyethylene (30) hydrogenated castor oil (manufactured by Nikko Chemicals), and ethanol (manufactured by Nippon Alcohol Sales Co., Ltd.) were used. POE in the table indicates polyoxyethylene.

[Experimental Example 1]
Liquid oral compositions having the compositions shown in Tables 1 and 2 were prepared by a conventional method, and the salivary secretion promoting effect was evaluated by the following method. The results are shown in Tables 1 and 2.

Evaluation method of salivary secretion promoting effect :
The saliva secretion amount was measured by the following procedure for 10 panelists who were thirsty due to intense exercise on the day before the test.
(1) The mouth was rinsed with 20 mL of physiological saline for 30 seconds.
(2) Thereafter, the amount of saliva accumulated after 30 minutes was measured while spitting the saliva into the sputum treatment device.
(3) Immediately after that, the mouth was rinsed with 20 mL of the test solution for 30 seconds.
(4) Similarly to (2), the amount of accumulated saliva after 30 minutes was newly measured.
The saliva secretion amount after the 30-minute physiological saline (control) mouthwash of 10 panelists was taken as 100%, and the average increase rate of the saliva secretion amount after the mouthwash of the test solution relative to the control was determined according to the following criteria. .
Evaluation criteria ◎: 150% ≦ salivation rate increase rate ○: 100% <saliva secretion rate increase rate <150%
×: Salivary secretion increase rate ≦ 100%

[Experiment 2]
About the liquid oral composition of the composition shown to Table 1, 2, the external appearance stability and the usability | use_condition were evaluated by the following method. The results are shown in Tables 1 and 2.

(1) Appearance stability 1: Ori sample is filled in 80 mL PET container with 80 mL filling volume, and appearance stability after storage for 1 month in -5 ° C constant temperature bath and room temperature (25 ° C constant temperature bath) is based on the following criteria. The visual judgment was made.
Evaluation standard ( double-circle): There is no orientation which settles when a PET container is moved gently.
○: Slight sedimentation is observed when the PET container is gently displaced, but there is no problem.
Δ: Orientation that settles when the PET container is gently displaced is clearly observed.
X: Orientation is recognized without transposing the PET container.

(2) Appearance stability 2: Nigori Fill the sample into 80 mL PET container with 80 mL filling capacity, and maintain appearance stability after 1 month storage at -5 ° C constant temperature bath and room temperature (25 ° C constant temperature bath) according to the following criteria. The visual judgment was made.
Evaluation Criteria A : There is no negative. Even if compared with a PET container filled with purified water, no scratch is observed.
○: Slight scratching is observed in comparison with a PET container filled with purified water, but there is no problem because the level cannot be determined without comparison.
Δ: Slightly observed as compared with a PET container filled with purified water. Slightly observed without comparison.
X: Nigori was clearly recognized without comparison with a PET container filled with purified water, and PET
It is so cloudy that it is difficult to see through the container.

(3) Usability evaluation After containing 10 mL of sample in the mouth and rinsing for 30 seconds, after the mouthwash, no irritation and moist feeling were evaluated in the following four stages in comparison with the control product (Comparative Example 2 or purified water). Then, the average score of 10 people is shown in the table with ◎, ○, Δ, × according to each evaluation standard.

No irritation after mouthwash (Control: Comparative Example 2)
4: The irritation was significantly lower than that of the control product.
3: Compared with the stimulus of the control product, the stimulus was slightly lower and there was no problem.
2: Stimulation equivalent to that of the control product was observed.
1: Stimulation was observed in comparison with the control product.
Evaluation criteria (no stimulation)
◎: Average point exceeding 3.0 point and 4.0 point or less ○: Average point exceeding 2.0 point and 3.0 point or less △: Average point 1.5 point or more and 2.0 point or less ×: Average point 1.0 to less than 1.5

Moisture in the mouth after mouthwash (control product: purified water)
4: Remarkably moist feeling in the oral cavity was felt compared to the control product.
3: A slightly moist feeling in the oral cavity was felt as compared with the control product.
2: No difference was observed in the moist feeling in the oral cavity compared with the control product.
1: The moist feeling in the oral cavity was weaker than that of the control product.
Evaluation criteria (a feeling of moisture in the oral cavity)
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

[Example 18] Mouthwash γ-polyglutamate sodium (4% viscosity 101 mPa · s) 1.0%
Lauroyl sarcosine sodium 0.1
Polyoxyethylene (60) hydrogenated castor oil 0.3
Glycerin 2
Propylene glycol 4
PEG (# 400) 3
Triclosan 0.05
Isopropyl methylphenol 0.05
Tranexamic acid 0.04
Dipotassium glycyrrhizinate 0.06
Citric acid 0.06
Sodium citrate 0.5
Methyl paraoxybenzoate 0.05
Saccharin sodium 0.01
Fragrance A 0.2
Water remaining
Total 100.0%

Example 19 Mouthwash γ-polyglutamate sodium (4% viscosity 62 mPa · s) 0.1%
Lauroyl sarcosine sodium 0.1
Polyoxyethylene (100) hydrogenated castor oil 0.6
Carboxymethylcellulose (Degree of etherification 2.3) 0.5
Glycerin 2
Propylene glycol 4
Polyethylene glycol (400) 5
Allantoin 0.05
Xylitol 5
ε-aminocaproic acid 0.03
Sodium benzoate 0.3
Citric acid 0.03
Sodium citrate 0.25
Fragrance B 0.2
Water remaining
Total 100.0%

[Example 20] mouthwash γ-polyglutamate potassium (4% viscosity 45 mPa · s) 0.3%
Myristoyl sarcosine sodium 0.1
Polyoxyethylene (40) hydrogenated castor oil 0.3
Glycerin 3
Propylene glycol 4
Butylene glycol 5
Triclosan 0.02
Xylitol 4
Acetic acid dl-α-tocophenol 0.05
Sodium fluoride 0.1
Citric acid 0.03
Sodium citrate 0.25
Fragrance C 0.3
Water remaining
Total 100.0%

[Example 21] mouthwash γ-polyglutamate potassium (4% viscosity 112 mPa · s) 0.3%
Palmitoyl sarcosine sodium 0.2
Polyoxyethylene (80) hydrogenated castor oil 0.5
Glycerin 3
Propylene glycol 4
Isopropylmethylphenol 0.06
Xylitol 4
Aspartame 0.02
Sodium pyrophosphate 0.17
Sodium polyphosphate 0.02
Citric acid 0.1
Sodium citrate 0.8
Fragrance D 0.4
Water remaining
Total 100.0%

[Example 22] Mouthwashing agent γ-polyglutamate sodium (4% viscosity 189 mPa · s) 0.5%
Lauroyl sarcosine sodium 0.2
Polyoxyethylene (100) hydrogenated castor oil 0.4
Sodium carboxymethylcellulose (degree of etherification 2.1) 0.3
Propylene glycol 4
Polyethylene glycol (600) 5
Saccharin 0.01
Aspartame 0.02
Copper chlorofin sodium 0.01
Dextranase 0.02
Sodium ascorbate 0.03
Citric acid 0.06
Sodium citrate 0.5
Fragrance E 0.2
Water remaining
Total 100.0%

[Example 23] Mouthwash γ-polyglutamate sodium (4% viscosity 84.5 mPa · s) 0.5%
Lauroyl sarcosine sodium 0.15
Polyoxyethylene (80) hydrogenated castor oil 0.5
Glycerin 2
Propylene glycol 4
Polyethylene glycol (400) 3
Xylitol 2
Trehalose 4
Sorbitol 1
Citric acid 0.03
Sodium citrate 0.5
Fragrance F 0.2
Water remaining
Total 100.0%

なお、表中の部は質量部を示す（以下、同様。）。

In addition, the part in a table | surface shows a mass part (following, the same).

Claims (2)

A liquid oral composition containing γ-polyglutamic acid or a salt thereof,
(A) N-acyl sarcosine sodium,
(B) The liquid oral composition characterized by mix | blending polyoxyethylene hydrogenated castor oil whose average addition mole number of ethylene oxide is 40-100 mol, and not mix | blending ethanol substantially.   Furthermore, (C) Carboxymethylcellulose sodium was mix | blended, The composition for liquid oral cavity of Claim 1 characterized by the above-mentioned.