JP5397181B2 - Oral spray composition and oral preparation - Google Patents

Description

  The present invention can continuously improve the dry feeling in the mouth due to dry mouth and the like over a long period of time immediately after use, and at the same time has a high persistence of cool feeling in the mouth, good use feeling, and aging. The present invention relates to an oral spray composition and an oral preparation excellent in storage stability.

  Dryness in the oral cavity is experienced in daily life and is accompanied by discomfort and bad breath, and may cause caries and periodontal disease. Such dryness in the oral cavity is often caused by a decrease in saliva secretion due to a decrease in oral function.

  As a technique for promoting saliva secretion, it is known that saliva secretion is promoted by stimulation of acids such as plum pickles, ume vinegar, and organic acids (Patent Document 1; JP-A-56-22719, Patent Document 2). ; See JP-A-7-101856). However, the stimulation by acid is temporary and does not lead to drastic improvement. Further, when acid is frequently applied, there are concerns about the influence on oral tissues such as dissolution of teeth and stimulation of oral mucosa.

  In addition, a method of maintaining a non-dry feeling in the oral cavity by using a moisturizing component such as hyaluronic acid and suppressing the dry feeling has been proposed (see Patent Document 3; International Publication No. 00/56344 pamphlet). It did not promote saliva secretion, and it was difficult to say that the sustainability and usability of the effect were sufficient.

  On the other hand, Patent Document 4 (International Publication No. 05/049050 pamphlet) proposes the use of polyglutamic acid (PGA) or a salt thereof as a means for promoting saliva secretion without irritation to oral tissues, Mouthwash solution containing sodium or potassium polyglutamate and mouth refresher, ammonium polyglutamate, citric acid, gargle tablets, polyglutamic acid ethanolamine salt, oral care system solution with water suction function Etc. are disclosed.

  Patent Document 5 (Japanese Patent Laid-Open No. 2005-015347) discloses that poly-γ-glutamic acid or a derivative thereof is effective as an active ingredient of a filaggrin synthesis promoter related to the moisturizing environment of the stratum corneum existing in the outermost layer of the skin. It is proposed that an external composition containing poly-γ-glutamic acid or a derivative thereof as an active ingredient is prepared into various types of cosmetics, specifically the composition of a mouth freshener. .

  However, the present inventors have examined a preparation containing polyglutamic acid or a salt thereof. As a result, in application to the oral cavity, it cannot be said that the sustainability of the effect over a long period of time immediately after use is sufficient and moisturizes in the mouth. There was room for improvement in terms of giving a sense of reality. Furthermore, when glycerin is added to a preparation containing polyglutamic acid or a salt thereof, it is effective for stabilization of the preparation, but a feeling of use with a feeling of heat is recognized particularly at a high concentration, and a cool feeling, particularly immediately after use. It was difficult to say that the sustainability of the cool feeling for a long time was sufficient, and it was found that there was room for improvement in the feeling of use in the mouth.

  Many techniques aimed at imparting a cool feeling have been proposed. For example, Patent Document 6 (Japanese Patent Application Laid-Open No. 2005-8535) discloses hair and body washing containing l-menthols and various cooling agents. Patent Document 7 (Japanese Patent Laid-Open No. 2007-2005) discloses that the cooling agent composition has an excellent cooling sensation, cooling sensation effect, and its sustainability, and a cooling effect obtained by combining l-menthols and various cooling agents. It is described that the fragrance | flavor composition which has this is mix | blended with the composition for oral cavity.

  However, in a preparation containing polyglutamic acid or a salt thereof as described above, the cooling sensation is slightly enhanced when the amount of l-menthol is increased, but the effect is not sufficient. The problem of inferiority occurred.

JP-A-56-22719 Japanese Patent Laid-Open No. 7-101856 International Publication No. 00/56344 Pamphlet International Publication No. 05/049050 Pamphlet JP 2005-015347 A JP 2005-8535 A JP 2007-2005 Gazette

  In preparations containing polyglutamic acid or its salts, the dry feeling in the mouth can be suppressed over a long period of time immediately after use in the oral cavity, maintaining a good moist feeling and satisfying the coolness in the mouth In addition, it is effective and desirable to improve the dry feeling in the mouth satisfactorily and continuously, but the conventional technology satisfies all of these requirements. It was difficult.

  The present invention has been made in view of the above circumstances, and its purpose is to solve the above-mentioned problems and continuously improve the dry feeling in the mouth due to dry mouth etc. over a long period of time immediately after application to the oral cavity. By providing a composition for oral spray and an oral preparation using the composition that is excellent in moisturizing effect in the mouth, excellent in cooling effect, excellent in use feeling and excellent in storage stability over time is there.

  As a result of intensive studies to achieve the above object, the present inventors have found that polyglutamate, a specific organic acid and its salt, 1-menthol, glycerin, a surfactant, and monomenthyl succinate. In combination with the above, and contained in a spray container, etc., sprayed into the oral cavity and applied, the dry feeling in the mouth due to dry mouth etc. is continuously applied over a long period of time immediately after application to the oral cavity It has been found that a preparation that can be improved, has an excellent moisturizing effect in the mouth, has an excellent cooling effect, has a good feeling of use, and has excellent storage stability over time.

  That is, in the present invention, polyglutamate, an organic acid and a salt thereof, and glycerin are blended in appropriate amounts, and l-menthol, a surfactant, and monomenthyl succinate are used in combination. Combining and combining the ingredients, storing them in a spray container, etc., and applying them by spraying them into the oral cavity, the effect of promoting saliva secretion derived from polyglutamate is effectively and continuously exerted, and the mouth feels moist. Can be continuously improved immediately after use, and the dry feeling in the mouth can be improved continuously for a long time immediately after application, and there is almost no decrease in the feeling of use with heat even when glycerin is blended at a high concentration. Excellent cooling sensation lasts for a long time immediately after use, has almost no bitterness during use, has a good feeling of use, and does not show deposits, orientation, or turbidity after storage, stable storage over time Also it will be good. Furthermore, the composition for oral cavity of the present invention has no irritation or stickiness to oral tissues such as oral mucosa during use, and the formulation contained in a spray container can be easily applied when necessary and is portable. And excellent convenience.

  In the present invention, as will be apparent from the examples described later, any of the essential requirements of the present invention is obtained by combining the following components (A) to (F), spraying them into the oral cavity and applying them. If it lacks, it has an excellent effect that cannot be achieved. Various substances have been conventionally proposed as components that give a cool sensation. However, in the present invention, a remarkable cool sensation can be obtained by selectively using monomenthyl succinate in 1-menthol. Even if menthyl lactate or N-ethyl-p-menthane-3-carboxamide is blended in place of menthyl succinate, the object of the present invention is not achieved.

Accordingly, the present invention provides the following oral spray composition and oral preparation.
Claim 1;
(A) polyglutamate, (B) one or more organic acids selected from citric acid and salts thereof, malic acid and salts thereof, tartaric acid and salts thereof, succinic acid and salts thereof, and (C) l- Contains menthol, (D) glycerin, (E) surfactant, and (F) monomenthyl succinate, and (A) component is 0.05 to 5% by mass, and (B) component is 2 to 6% by mass. The composition for oral sprays which mix | blends 10-50 mass% of (D) component, and 0.01-0.3 mass% of (F) component.
Claim 2;
The composition for oral spray according to claim 1, wherein the mass ratio of the component (D) to the component (F) ((D) / (F)) is 100 to 3,000.
Claim 3;
The composition for oral spray according to claim 1 or 2, wherein 0.01 to 0.4% by mass of component (C) and 1 to 10% by mass of component (E) are blended.
Claim 4;
(E) Surfactant is polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100, an alkyl group having 16 to 18 carbon atoms, and an average addition mole number of ethylene oxide of 20 to 50 4. The polyoxyethylene alkyl ether, the fatty acid is one or more selected from polyoxyethylene sorbitan fatty acid esters having 16 to 18 carbon atoms and an average addition mole number of ethylene oxide of 10 to 30. Oral spray composition.
Claim 5;
An oral preparation comprising the composition for oral spray according to any one of claims 1 to 4 contained in a spray container.

  The composition for oral spray of the present invention and the preparation for oral cavity are satisfactory as well as being able to realize a sense of moisture in the mouth immediately after use by simply spraying into the oral cavity when the user is concerned about dryness in the mouth. A cool sensation is felt, the moist feeling and the persistence of the cool sensation are high, and the storage stability of the preparation over time is also excellent. The preparation of the present invention is effective in preventing or improving xerostomia.

It is a general | schematic fragmentary sectional view which shows one Example of the spray container concerning this invention.

  Hereinafter, the present invention will be described in more detail. The composition for oral spray of the present invention comprises (A) polyglutamate, (B) organic acid and its salt, (C) 1-menthol, (D) glycerin, (E) surfactant, (F) monomenthyl. Contains succinate.

Polyglutamate is blended as an active ingredient for promoting salivary secretion, and a sodium or potassium salt of polyglutamic acid is preferable.
Examples of the polyglutamate include sodium or potassium salts of α or γ-polyglutamic acid that are chemically synthesized, or natural α or γ-polyglutamic acid sodium or potassium salts obtained as fermentation products from various strains. Although it can be used, a natural one is preferable because it is used for oral use, and sodium or potassium γ-polyglutamate having high productivity as a raw material is more preferable.

  The viscosity of the polyglutamate is not particularly limited, and those having various viscosities can be used depending on the type of the product. However, the viscosity of a 4% by mass aqueous solution measured by the method described later is 10 to 200 mPa · s, particularly 30 to 30 mPa · s. The range is preferably 120 mPa · s. When the viscosity is less than 10 mPa · s, the salivary secretion promoting action may be insufficient. When it exceeds 200 mPa · s, the viscosity of the preparation increases, and the sprayability of the spray during use may deteriorate.

Viscosity measuring method In a 200 mL beaker, 96 g of water was taken, and while stirring with a stirrer, 4.0 g of polyglutamic acid or a salt thereof was added and completely dissolved. Next, after leaving still in a 25 degreeC thermostat for 1 hour, the viscosity after 1 minute was measured correctly using the following BL type | mold viscometer.
BL type viscometer: Tokyo Keiki B type viscometer Model BL
Rotor: No. 2 Number of revolutions: 60 rpm Measurement temperature: 25 ° C

  As the polyglutamate, a commercially available product can be used. For example, as γ-polyglutamate sodium, Meiji polyglutamate manufactured by Meiji Food Materials Co., Ltd. can be used.

  The compounding quantity of polyglutamate is 0.05-5 mass% of the whole composition, Preferably it is 0.1-2 mass%, Most preferably, it is 0.4-1.5 mass%. If the amount is less than 0.05% by mass, the effect of promoting salivation is not sufficiently exhibited, and a moist feeling cannot be sufficiently obtained. If the amount exceeds 5% by mass, it is difficult to develop a cool feeling and the storage stability with time is poor.

Component (B) is an organic acid and a salt thereof, and in the present invention, (B) an organic acid, a salt thereof, and (D) glycerin are used together to continuously moisturize the mouth immediately after application. And good formulation stability is achieved.
As the organic acid and its salt, one or more organic acids selected from citric acid, malic acid, tartaric acid and succinic acid and alkali metal salts thereof (sodium salt, potassium salt, etc.) are used. Contains citric acid and its salt, malic acid and its salt, tartaric acid and its salt, and succinic acid and its salt. Among these, a combination of citric acid and sodium citrate, or malic acid and sodium malate is preferable from the viewpoint of moist feeling in the mouth and formulation stability.

  The total amount of the organic acid and the organic acid salt is 2 to 6% by mass, preferably 2.5 to 5% by mass, based on the entire composition. If it is less than 2% by mass, a moist feeling immediately after application of the preparation cannot be obtained satisfactorily, and if it exceeds 6% by mass, no further effect is obtained, resulting in a strong bitter taste or problems with storage stability over time. .

Further, the blending amount of the organic acid and the organic acid salt is within the above total blending amount (the blending amount of the organic acid) ≦ (the blending amount of the organic acid salt), particularly (the blending amount of the organic acid) <(the organic acid). The blending amount of the salt is desirable.
In this case, the compounding amount of the organic acid is preferably 0.01 to 1.5% by mass, particularly preferably 0.1 to 0.5% by mass. If it is less than 0.01% by mass, a sufficient moist feeling in the mouth immediately after application of the preparation cannot be obtained.
The compounding amount of the organic acid salt is preferably 1.5 to 5.9% by mass, particularly preferably 1.8 to 4.9% by mass. If it is less than 1.5% by mass, the effect of moist feeling in the mouth immediately after application of the preparation is inferior, and if it exceeds 5.9% by mass, bitterness may be strongly produced or stability over time may be inferior.

  Moreover, it is preferable to adjust the compounding quantity of (B) component which combined the organic acid and the organic acid salt in the range from which the pH in 25 degreeC of a formulation will be 5-8. If the pH exceeds 8, the oral mucosa may be stimulated.

  (C) As l-menthol, l-menthol may be blended as it is, or an essential oil containing l-menthol, for example, peppermint oil, light cargo oil, etc. may be blended. L-menthol and l-menthol-containing essential oil However, it is more preferable to add l-menthol as it is to impart a cool feeling. As the l-menthol, commercially available products such as menthol JP (trade name) manufactured by Takasago International Corporation can be used. As essential oils containing l-menthol, commercially available peppermint oil (l-menthol content 35-60% by mass) (manufactured by Takasago Fragrance Co., Ltd.) and Japanese-type thin cargo oil (l-menthol content 30-50 mass) %) (Manufactured by Toyo Hikaru Kogyo Co., Ltd.) or the like.

  The blending amount of menthol is preferably 0.01 to 0.4% by mass, particularly 0.03 to 0.3% by mass, based on the total amount of the composition in terms of pure content. When the blending amount is less than 0.01% by mass, a sufficient cooling sensation may not be obtained. When the blending amount exceeds 0.4% by mass, the bitterness and irritation may be strong and unfavorable in use. In addition, as for the essential oil containing menthol, it is desirable to mix | blend so that content of menthol may become in the said range.

  (D) The compounding quantity of glycerol is 10-50 mass% of the whole composition, Preferably it is 15-40 mass%, More preferably, it is 15-30 mass%. If the amount is less than 10% by weight, the moisture in the mouth is inferior, and the storage stability of the preparation may deteriorate. Further, irritation to the oral mucosa may occur. Inferiority, cool feeling in the mouth, and storage stability over time of the preparation cannot be obtained satisfactorily.

  (E) As for surfactant, 1 type, or 2 or more types chosen from a nonionic surfactant, anionic surfactant, and an amphoteric surfactant are suitable.

  Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, maltitol fatty acid ester, and lactitol fatty acid ester. Sugar alcohol fatty acid esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, myristic acid mono- or diethanolamine Fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxy Propylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester or the like is used. In particular, a type to which ethylene oxide is added is preferable, and in particular, polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100, polyoxyethylene alkyl ether and ethylene oxide having an average addition mole number of ethylene oxide of 20 to 50 A polyoxyethylene sorbitan fatty acid ester having an average added mole number of 10 to 30 is preferable, and among them, the polyoxyethylene hydrogenated castor oil is more preferable.

  Examples of the anionic surfactant include alkyl sulfates having 8 to 18 carbon atoms in the alkyl group such as sodium lauryl sulfate, sodium myristyl sulfate, and cetyl sulfate, N-sodium N-lauroyl glutamate, sodium N-palmitoyl glutamate, and the like. N-acyl glutamic acid sodium, N-lauroyl sarcosine sodium, N-acyl sarcosine sodium such as N-myristoyl sarcosine sodium, N-methyl-N-acyl taurine sodium such as N-lauroyl methyl taurine sodium, N-myristoyl methyl taurine sodium, N -Sodium methyl-N-acylalanine, sodium lauryl benzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate Potassium, alpha-sodium olefin sulfonate, lauryl polyoxyethylene (POE) sodium sulfate, sodium lauryl POE acetate, sodium lauryl POE phosphate, sodium stearyl POE phosphate, sodium surfactin or the like is used. Of these, alkyl sulfates (particularly lauryl sulfate) are preferred.

  Zwitterionic surfactants include alkyldimethylaminoacetic acid betaines such as lauryldimethylaminoacetic acid betaine, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, and N-alkyl-N-carboxyl. Methyl ammonium betaine, 2-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like are used.

  As the surfactant, nonionic surfactant, especially polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100, an alkyl group having 16 to 18 carbon atoms, and an average addition of ethylene oxide Polyoxyethylene alkyl ether having a mole number of 20 to 50, a type in which ethylene oxide selected from polyoxyethylene sorbitan fatty acid esters having a fatty acid number of 16 to 18 and an average addition mole number of ethylene oxide of 10 to 30 is added. Is preferably blended.

  The total compounding amount of the surfactant is preferably 1 to 10% by mass, particularly 1 to 5% by mass, based on the entire composition. If the blending amount of the surfactant is less than 1% by mass, the surfactant is not uniformly dissolved, and if it exceeds 10% by mass, the bitterness may occur and the feeling of use may be deteriorated.

  (F) Monomenthyl succinate is a fragrance material and is used not only for oral compositions but also for foods and the like as a component that imparts a cool feeling. As monomenthyl succinate, a commercially available synthetic product can be used, and Fischer (trade name) manufactured by Ve Manfis Fragrance Co., Ltd. can be used.

  The blending amount of monomenthyl succinate is preferably 0.01 to 0.3% by mass, particularly 0.02 to 0.2% by mass, and particularly preferably 0.02 to 0.1% by mass based on the total composition. When the blending amount is less than 0.01% by mass, a sufficient cooling sensation may not be obtained. When the blending amount exceeds 0.3% by mass, the cooling sensation is rather suppressed, resulting in inhibition of flavor expression and bitterness. There may not be.

  In the present invention, in addition to monomenthyl succinate, other known cooling sensation agents may be added as cooling sensation imparting agents. For example, 3-L-menthoxypropane-1,2-diol, menthyl lactate, menthyl glycerin acetal, N-ethyl-p-menthane-3-carboxamide and the like can be mentioned, and one or more of these can be added. . Specifically, 3-L-menthoxypropane-1,2-diol is a cooling agent CA10 (trade name) manufactured by Takasago International Corporation, and menthyl lactate is FRESCOLAT ML (trade name), Menthyl manufactured by Simrise Co., Ltd. As glycerin acetal, commercially available products such as FRESCOLAT MGA (trade name) manufactured by Simrise Co., Ltd. and N-ethyl-p-menthane-3-carboxamide as WS3 manufactured by Dibodan Co., Ltd. can be used. The addition amount in the case of adding these cooling agents is desirably in a range where the total blending amount is 0.01 to 0.3% by mass including monomenthyl succinate.

  In the present invention, the mass ratio of the (D) component to the (F) component ((D) / (F)) is preferably 100 to 3,000, particularly 200 to 1,000, and particularly preferably 200 to 800. If the ratio is less than 100, the bitterness may be strongly generated, and if it exceeds 3,000, the cool feeling immediately after use may be reduced, and the use feeling may be inferior.

  The composition for oral spray of the present invention is prepared in a liquid or liquid form, and in addition to the above-described components, other known components can be blended as necessary within a range not impeding the effects of the present invention. For example, moisturizing ingredients, wetting agents other than glycerin, water-soluble polymer substances, solvents, antiseptic ingredients, fragrances, active ingredients other than polyglutamate and monomenthyl succinate can be blended.

  Specifically, moisturizing components such as hyaluronic acid salt, and as a wetting agent, sugar alcohols such as xylitol, erythritol, sorbitol, mannitol, reduced lactose, reduced maltose starch syrup, reduced starch syrup, propylene glycol, 1,3-butylene glycol, Polyhydric alcohols other than glycerin, such as polyethylene glycol, and water-soluble polymer substances such as sodium carboxymethylcellulose, polyvinylpyrrolidone, xanthan gum, carrageenan, sodium alginate, and the like can be used in combination.

  When blending the above optional components, the amount of the moisturizing component is 0.001 to 1% by mass, the amount of sugar alcohols is 0.1 to 20% by mass, and the amount of polyhydric alcohol is 0.1 to 10% by mass. %, And the amount of the water-soluble polymer substance is preferably 0.01 to 1% by mass.

  In addition, as an active ingredient, an anti-cariogenic ingredient such as fluoride (such as sodium fluoride), an enzyme such as dextranase or mutanase, an ingredient for preventing or suppressing hypersensitivity such as aluminum lactate, potassium nitrate or piroctone olamine, or cetylpyridinium chloride , Anti-inflammatory components such as benzethonium chloride, benzalkonium chloride, isopropylmethylphenol, glycyrrhizic acid, dipotassium glycyrrhizinate, ε-aminocaproic acid, and other water-soluble polyphosphates such as potassium pyrophosphate, sodium tripolyphosphate, sodium metaphosphate An effective amount of a herb extract such as a salt, ascorbic acid or a salt thereof, tocopherol acetate, rosemary, clove, thyme and the like can be blended.

  As perfumes, natural essential oils such as spearmint oil, eucalyptus oil, winter green oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, and Fragrance components contained in the above natural essential oils such as l-carvone, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spirantol, etc. Acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl malto , Gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol 1-menthyl carbonate, and some other perfume ingredients 1 or 2 or more kinds of blended flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt It can be added in an amount of 0.00001 to 3% by mass in the composition as long as the effects of the present invention are not hindered.

Furthermore, parabens (paraoxybenzoic acid ester) such as benzoic acid and its sodium salt, methylparaben, ethylparaben, propylparaben, butylparaben, etc., as a preservative component, Red No. 3, Red No. 104, Red No. 106, Yellow No. 4, Blue No. 1, Green No. 3, pigments or colorants such as titanium mica, petiole, xylitol, saccharin and its sodium salt, sweeteners such as sucralose, stevioside, glycyrrhizin, aspartame, and the like can be blended.
As the solvent, purified water is usually used, and a lower alcohol having 3 or less carbon atoms such as ethanol can be further added.
In addition, 10-60 mPa * s is suitable for the viscosity of this invention composition. In addition, a viscosity is the value which measured the viscosity after 1 minute correctly using the following BL type | mold viscometer after leaving still in a 25 degreeC thermostat for 1 hour.
BL type viscometer: Tokyo Keiki B type viscometer Model BL
Rotor: No. 2 Number of revolutions: 60 rpm Measurement temperature: 25 ° C

  In the composition for oral spray of the present invention, a liquid or liquid composition for oral cavity containing the above components is accommodated in a container, and is applied by spraying into the oral cavity at the time of use. In this case, the container is not particularly limited as long as it has a structure capable of spraying a medicine. Specifically, a pressing portion of a spray unit that is provided in close contact with the upper opening of the container main body, including a container main body such as a plastic bottle for storing contents and a spray unit having a spray mechanism such as a pump dispenser. By pressing, the contents contained in the container body can be sprayed and discharged from the contents discharge port (nozzle) by the contents discharge mechanism of the spray section (hereinafter abbreviated as spray container). .

  A commercial item may be used for such a spray container, for example, the dispenser part of a spray container is Y-20 (1 push about 0.02mL discharge | emission) and Y-70 (1 push about 0.0. 07-mL discharge), Y-150 (1 push about 0.15 mL discharge), etc., Mitani Valve Co., Ltd. Z-155 (1 push 0.15 mL discharge), etc., and the bottle part is made by Yoshino Kogyo A polyethylene terephthalate bottle corresponding to a dispenser, a PEI-30 bottle made of Takemoto Container, and the like are commercially available. As for the dispenser part of the spray container, Japanese Utility Model Publication No. 55-373, Japanese Utility Model Publication No. 56-21476, Japanese Patent Application Laid-Open No. 60-32505 are disclosed.

FIG. 1 is a schematic sectional view showing an embodiment of a spray container that can be used in the present invention. The dispenser part of this spray container is marketed as a polyethylene terephthalate bottle (both manufactured by Yoshino Kogyo) corresponding to Y-70 and the bottle part corresponding to Y-70.
The container shown in FIG. 1 includes a container main body 1 for storing contents and a spray unit 2 having a spray mechanism. The spray unit 2 is in close contact with an upper opening of the container main body 1 by a cap 4 having a packing 3. The spray unit 2 is inserted into the container main body 1 with the lower projecting portion of the cylinder 6 serving as the content inflow path of the content discharge mechanism 5 provided with the tube 7 at the tip opening. . This container presses the pressing part 8 of the spray part 2 so that the piston 9 moves up and down in the cylinder 6 along the cylinder guide 10, so that the contents in the container main body 1 become the lower opening of the tube 7. Then, it is sucked up through a ball 11 for adjusting the flow rate in the cylinder 6 and is sprayed and discharged from the nozzle 13 of the content discharge port through the head cylinder 12. In addition, the overcap 14 can be covered on the spray part 2 as needed.

The shape of the spray part constituting the spray container, the content discharge mechanism, the diameter and shape of the nozzle and the like can be freely used as long as they are generally used, and are not particularly limited. The diameter of the nozzle hole through which the object is discharged is preferably 0.1 to 1 mm, particularly 0.3 to 0.8 mm. The spray amount by spraying is preferably 0.01 to 0.5 mL per push. The container body preferably has a height of 40 to 100 mm and a width of 15 to 50 mm, and a capacity of about 5 to 50 mL is suitable.
Use of such a container is effective for exerting more excellent sprayability and moisturizing effect in the mouth.

  The material of the spray container is not particularly limited, but the material of the spray part is preferably polyethylene, polypropylene, polyacetal or the like, and the material of the container body is preferably polyethylene terephthalate or the like.

The material of each part of the spray container of FIG. 1 can be as follows, for example.
Container body 1 (bottle) (polyethylene terephthalate)
Packing 3 (Polyethylene double-sided polypropylene attached)
Cap 4 (polypropylene)
Cylinder 6, cylinder guide 10, head cylinder 12 (polypropylene)
Tube 7 (polyethylene)
Press part 8 (polyethylene)
Piston 9 (polyethylene)
Ball 11 (SUS304 stainless steel)
Nozzle 13 (polyacetal)

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% is mass% unless otherwise specified.

[Examples 1 to 32, Comparative Examples 1 to 14]
The composition for oral sprays of the composition shown in Tables 1-8 was prepared by the following method, and the following evaluation was performed. The results are shown in Tables 1-8. In addition, the viscosity of the composition of the following example is the value which measured the viscosity after 1 minute exactly using the following BL type | mold viscometer after leaving a composition in a 25 degreeC thermostat bath for 1 hour. It was in the range of 10 to 60 mPa · s.
BL type viscometer: Tokyo Keiki B type viscometer Model BL
Rotor: No. 2 Number of revolutions: 60 rpm Measurement temperature: 25 ° C

Formulation preparation:
Each component was weighed and prepared by mixing with a stirrer. 30 g of the prepared liquid is filled into a spray container (Y-70 dispenser made by Yoshino Kogyo, nozzle hole 0.55 mm, spray amount of 1 push is about 0.07 mL, capacity 30 mL polyethylene terephthalate bottle), and the test preparation is filled Obtained.
As sodium γ-polyglutamate in the table, a natural product (trade name; Meiji polyglutamate) manufactured by Meiji Food Materia Co., Ltd. was used. For citric acid, malic acid, tartaric acid, succinic acid and salts thereof, those manufactured by Fuso Chemical Co., Ltd. were used. 1-menthol is menthol JP manufactured by Takasago International Inc., peppermint oil is manufactured by Takasago International Inc. (1-menthol content 42%), and Japanese light oil is manufactured by Toyo Light Industrial Co., Ltd. (1- Menthol content 38%) was used. As the glycerin, 85% glycerin manufactured by Sakamoto Pharmaceutical Co., Ltd. was used. As the surfactant, POE hydrogenated castor oil (manufactured by Nikko Chemicals Co., Ltd., HCO-60) was used. NIKKOL BC-30 manufactured by Nikko Chemicals Co., Ltd. was used for polyoxyethylene (30) cetyl ether, and NIKKOL TO-10V manufactured by Nikko Chemicals Co., Ltd. was used for polyoxyethylene (20) sorbitan monooleate. As the monomenthyl succinate, Fisman manufactured by Ve Manfis Fragrance Co., Ltd. was used.
For the sodium dihydrogen phosphate and disodium hydrogen phosphate used as comparative products, Taihei Chemical Industry Co., Ltd. products were used. Menthyl lactate was manufactured by Simrise Co., Ltd. (trade name; FRESCOLAT), and N-ethyl-p-menthane-3-carboxamide was manufactured by Dibodan Co., Ltd. (trade name: WS3).
Moreover, in Examples 1-38 and Comparative Examples 1-14, about components other than peppermint oil and Japanese-type thin cargo oil, the value converted into a pure part was shown.

<Mouth coolness and moisture when used, no bitterness>
Ten panelists who were concerned about dry mouth in daily life used the preparation. Spray the test preparation into the mouth of 5 pushes (approx. 0.35 mL) immediately after use, cool feeling in the mouth after 10 minutes, and moist feeling in the mouth after 5 minutes, 30 minutes after use, no bitterness during use Was evaluated according to the following criteria, and 10 evaluation points were obtained and evaluated according to the following criteria.

(I) Cool feeling in mouth immediately after use Comparative Example 10 was used as a standard product and evaluated according to the following criteria.
(Score)
4 points: Cool feeling is very strong compared to Comparative Example 10 3 points: Cool feeling is strong compared to Comparative Example 10 2 points: Cool feeling is slightly stronger than Comparative Example 10 1 point: Compared to Comparative Example 10 The average feeling of the panelists was calculated and evaluated as follows.
(Evaluation criteria)
◎: Average score is 3.5 or more and 4.0 or less ○: Average score is 3.0 or more and less than 3.5 △: Average score is 2.0 or more and less than 3.0 ×: Average score is 1.0 to less than 2.0

(Ii) Cooling sensation in the mouth after 10 minutes of use Comparative Example 10 was used as a standard product and evaluated according to the following criteria.
(Score)
4 points: Cool feeling is very strong compared to Comparative Example 10 3 points: Cool feeling is strong compared to Comparative Example 10 2 points: Cool feeling is slightly stronger than Comparative Example 10 1 point: Compared to Comparative Example 10 The average feeling of the panelists was calculated and evaluated as follows.
(Evaluation criteria)
◎: Average score is 3.5 or more and 4.0 or less ○: Average score is 3.0 or more and less than 3.5 △: Average score is 2.0 or more and less than 3.0 ×: Average score is 1.0 to less than 2.0

(Iii) 5 minutes after use, moist feeling in the mouth after 30 minutes (score)
7 points: I feel very much 6 points: I feel quite 5 points: I feel a little 4 points: I can't say either 3 points: I don't feel much 2 points: I don't feel almost 1 point: I don't feel at all It evaluated as follows.
(Evaluation criteria)
◎: Average point is 6.0 points or more ○: Average point is 5.0 points or more and less than 6.0 points △: Average point is 4.0 points or more and less than 5.0 points ×: Average point is less than 4.0 points

(Iv) No bitterness when using (score)
4 points: feels no bitterness 3 points: feels bitterness 2 points: feels bitterness 1 point: feels bitterness A panel average score was calculated and evaluated as follows.
(Evaluation criteria)
◎: Average score is 3.5 or more and 4.0 or less ○: Average score is 3.0 or more and less than 3.5 △: Average score is 2.0 or more and less than 3.0 ×: Average score is 1.0 to less than 2.0

<Stability evaluation of formulation>
The prepared preparation was filled in a spray container with a capacity of 30 mL and allowed to stand for 1 month under a temperature condition of −5 ° C. or 50 ° C., and the appearance and properties were visually evaluated according to the following criteria to evaluate the stability of the preparation.
○: Colorless and transparent with no precipitates Δ: Slight orientation is observed ×: Significant precipitates or turbidity is observed

  From the results shown in Tables 1 to 8, the composition for oral spray of the present invention has high cooling sensation and moisturizing feeling in the mouth immediately after application, little bitterness, little deterioration over time for the preparation, and excellent usability. It was confirmed that.

  In the same manner as described above, the same raw materials were used to prepare an oral preparation having the following composition, filled in a spray container similar to the above, and evaluated according to the above evaluation method. In addition, as γ-polyglutamate sodium and γ-polyglutamate potassium, natural products manufactured by Meiji Food Materia Co., Ltd. were used. In addition, the viscosity (25 degreeC) of the following composition was all in the range of 10-60 mPa * s similarly to the said example.

Example 33
Component A sodium γ-polyglutamate 2.0%
(4% aqueous solution viscosity: 12 mPa · s)
B component Citric acid 0.32
B component Sodium citrate 3.68
C component l-menthol 0.2
D component Glycerin 20
E component Polyoxyethylene (60) hydrogenated castor oil 3
F component Monomenthyl succinate 0.05
Ethanol 15
Xylitol 5
Reduced lactose 5
l-Menthol 0.2
Fragrance B 0.3
Purified water remaining
Total 100%
Mass ratio of D component / F component: 400
Cool feeling (immediately after 10 minutes) A, moist feeling (after 5 minutes and 30 minutes later) A, no bitterness A, storage stability (both −5 ° C. and 50 ° C.) A.

Example 34
A component γ-Polyglutamate potassium 0.5%
(4% aqueous solution viscosity: 45 mPa · s)
B component Citric acid 0.5
B component Sodium citrate 3.5
C component l-menthol D component Glycerin 25
E component Polyoxyethylene (20) sorbitan monooleate 3
F component Monomenthyl succinate 0.05
Polyvinylpyrrolidone (K90) 0.3
Ethanol 10
Sorbitol 5
Erythritol 5
Sodium fluoride 0.05
Sodium benzoate 0.1
Fragrance C 0.3
Purified water remaining
Total 100%
Mass ratio of D component / F component: 500
Cool feeling (immediately after 10 minutes) A, moist feeling (after 5 minutes and 30 minutes later) A, no bitterness A, storage stability (both −5 ° C. and 50 ° C.) A.

Example 35
A component sodium γ-polyglutamate 0.5%
(4% aqueous solution viscosity: 84.5 mPa · s)
B component Citric acid 0.2
B component Sodium citrate 3.8
C component l-menthol 0.1
D component Glycerin 25
E component Polyoxyethylene (30) cetyl ether 3
F component Monomenthyl succinate 0.05
Sodium hyaluronate 0.01
Ethanol 10
Maltitol 5
Xylitol 5
Cetylpyridinium chloride 0.02
Fragrance D 0.3
Purified water remaining
Total 100%
Mass ratio of D component / F component: 500
Cool feeling (immediately after 10 minutes) A, moist feeling (after 5 minutes and 30 minutes later) A, no bitterness A, storage stability (both −5 ° C. and 50 ° C.) A.

Example 36
A component sodium γ-polyglutamate 0.5%
(4% aqueous solution viscosity: 101 mPa · s)
B component Citric acid 0.1
B component sodium citrate 3.9
C component l-menthol 0.1
D component Glycerin 15
E component Polyoxyethylene (60) hydrogenated castor oil 3
F component Monomenthyl succinate 0.05
Propylene glycol 2
Polyethylene glycol # 400 3
Sodium carboxymethylcellulose (Ernest gum) 0.1
Ethanol 10
Sorbitol 5
Xylitol 5
Cetylpyridinium chloride 0.02
Fragrance E 0.3
Purified water remaining
Total 100%
Mass ratio of D component / F component: 300
Cool feeling (immediately after 10 minutes) A, moist feeling (after 5 minutes and 30 minutes later) A, no bitterness A, storage stability (both −5 ° C. and 50 ° C.) A.

Example 37
Component A sodium γ-polyglutamate 0.1%
(4% aqueous solution viscosity: 189 mPa · s)
B component Citric acid 0.32
B component Sodium citrate 3.68
C component l-menthol 0.2
D component Glycerin 20
E component Polyoxyethylene (60) hydrogenated castor oil 3
F component Monomenthyl succinate 0.05
Ethanol 10
Sorbitol 15
Xylitol 1
Sodium carboxymethylcellulose (Ernest gum) 0.2
Fragrance F 0.3
Purified water remaining
Total 100%
Mass ratio of D component / F component: 400
Cool feeling (immediately after 10 minutes) A, moist feeling (after 5 minutes and 30 minutes later) A, no bitterness A, storage stability (both −5 ° C. and 50 ° C.) A.

Example 38
A component sodium γ-polyglutamate 0.5%
(4% aqueous solution viscosity: 84.5 mPa · s)
B component Citric acid 0.32
B component Sodium citrate 3.68
C component l-menthol 0.1
D component Glycerin 30
E component Polyoxyethylene (60) hydrogenated castor oil 3
F component Monomenthyl succinate 0.05
Ethanol 10
Xylitol 5
Sodium carboxymethylcellulose (Ernest gum) 0.1
Lemon essential oil 0.1
Fragrance A 0.1
Purified water remaining
Total 100%
Mass ratio of D component / F component: 600
Cool feeling (immediately after 10 minutes) A, moist feeling (after 5 minutes and 30 minutes later) A, no bitterness A, storage stability (both −5 ° C. and 50 ° C.) A.
In addition, the fragrance | flavors AF are the compositions as follows. Menthol and monomenthyl succinate are not contained in the following fragrance composition.

DESCRIPTION OF SYMBOLS 1 Container body 2 Spray part 3 Packing 4 Cap 5 Contents discharge mechanism 6 Cylinder 7 Tube 8 Press part 9 Piston 10 Cylinder guide 11 Ball 12 Head cylinder 13 Nozzle 14 Overcap

Claims (5)

  (A) polyglutamate, (B) one or more organic acids selected from citric acid and salts thereof, malic acid and salts thereof, tartaric acid and salts thereof, succinic acid and salts thereof, and (C) l- Contains menthol, (D) glycerin, (E) surfactant, and (F) monomenthyl succinate, and (A) component is 0.05 to 5% by mass, and (B) component is 2 to 6% by mass. The composition for oral sprays which mix | blends 10-50 mass% of (D) component, and 0.01-0.3 mass% of (F) component.   The composition for oral spray according to claim 1, wherein the mass ratio of the component (D) to the component (F) ((D) / (F)) is 100 to 3,000.   The composition for oral spray according to claim 1 or 2, wherein 0.01 to 0.4% by mass of component (C) and 1 to 10% by mass of component (E) are blended.   (E) Surfactant is polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100, an alkyl group having 16 to 18 carbon atoms, and an average addition mole number of ethylene oxide of 20 to 50 4. The polyoxyethylene alkyl ether, the fatty acid is one or more selected from polyoxyethylene sorbitan fatty acid esters having 16 to 18 carbon atoms and an average addition mole number of ethylene oxide of 10 to 30. Oral spray composition.   An oral preparation comprising the composition for oral spray according to any one of claims 1 to 4 contained in a spray container.

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