JP5874383B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition suitable for a liquid preparation, in which the irritating feeling of glycerophosphoric acid or a salt thereof is suppressed, the astringency and taste are improved, and a good feeling of use is given.

  Patent Document 1 (Japanese Patent Application Laid-Open No. 2005-47855) proposes that glycerophosphoric acid and its salt are effective in suppressing oral biofilms. Among them, calcium glycerophosphate is considered to increase calcium and phosphate concentrations in plaque to promote remineralization, prevent a significant decrease in plaque pH, and inhibit mutans bacteria metabolism.

  However, glycerophosphoric acid and salts thereof have a sense of irritation, astringency and taste, and for this reason, oral compositions containing glycerophosphoric acid or salts thereof, particularly liquid oral compositions such as mouthwashes, There was a problem that the aftertaste was bad and the feeling of use was impaired.

  Regarding the improvement of astringency and off-taste of glycerophosphoric acid and its salt, Patent Document 2 (Japanese Patent Laid-Open No. 2009-149560) incorporates raffinose and / or melibiose into calcium glycerophosphate and sodium monofluorophosphate. Although it has been proposed that the astringency and bitterness derived from calcium phosphate and sodium monofluorophosphate are suppressed, there is no indication of irritation and relaxation.

  A technique for reducing astringency, bitterness and pungent taste by blending calcium glycerophosphate with lactone and propylene glycol alginate has been proposed in Patent Document 3 (Japanese Patent Laid-Open No. 2010-215568). However, this technique has a problem that the propylene glycol alginate becomes sticky, and there is room for improvement in the feeling of use. Moreover, there existed a subject that the kind of flavor which can be used was limited.

JP-A-2005-47855 JP 2009-149560 A JP 2010-215568 A

Therefore, in the composition for oral cavity, suppression of the irritating feeling of glycerophosphoric acid and its salt and improvement of astringency and taste have been problems.
The present invention has been made in order to solve the above-mentioned problems, and provides an oral composition that suppresses the irritating feeling of glycerophosphoric acid or a salt thereof, improves astringency and taste, and gives a good feeling of use. For the purpose.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) glycerophosphoric acid or a salt thereof and (B) glycyrrhizic acid or a salt thereof are (B) / (A) in a mass ratio. As a combined use in the range of 0.2 to 10 , especially in a liquid oral composition, the irritating feeling of glycerophosphoric acid or a salt thereof is suppressed, and the astringency / taste is improved. It has been found that an oral composition giving a feeling can be obtained.

  Furthermore, it has been found that the use feeling is further enhanced when one or more components selected from (C) vanilla absolute, vanillin, ethyl vanillin and nutmeg oil are blended.

Accordingly, the present invention provides the following oral composition.
[1] 0.01-0.2% by mass of (A) glycerophosphoric acid or a salt thereof , and (B) 0.01-0.2% by mass of glycyrrhizic acid or a salt thereof , (a) is an oral composition which is a 0.2 to 10 as a mass ratio.
[2] The composition for oral cavity according to [1], further comprising (C) 0.0000001 to 0.004% by mass of one or more components selected from vanilla absolute, vanillin, ethyl vanillin and nutmeg oil.

  ADVANTAGE OF THE INVENTION According to this invention, the irritation | stimulation feeling of glycerophosphoric acid or its salt is suppressed, astringency and taste are improved, and the composition for oral cavity which gives a favorable usability | use_condition can be provided.

  The present invention will be described in further detail below. The composition for oral cavity of this invention contains (A) glycerophosphoric acid or its salt, and (B) glycyrrhizic acid or its salt.

  Examples of the glycerophosphoric acid or salt thereof as component (A) include glycerophosphoric acid, alkali metal salts such as sodium salt and potassium salt thereof, and alkaline earth metal salts such as calcium salt. More than seeds can be mixed and blended. Among these, calcium glycerophosphate is more preferable from the viewpoint of effect expression.

  As the component (A), any of natural products and synthetic products can be used. For example, calcium glycerophosphate can be used from a natural product or a synthetic product. For example, a commercially available product such as a trade name “Calcium glycerophosphate” manufactured by Iwaki Pharmaceutical Co., Ltd. can be used.

  The blending amount of the component (A) is preferably 0.005 to 1% (mass%, hereinafter the same) of the whole composition, more preferably 0.01 to 0.2%. If it is less than 0.005%, the blending effect may not be satisfactorily exhibited. If it exceeds 1%, the irritation feeling, astringency and off-taste derived from the component (A) may become strong and the feeling of use may be impaired.

The component (B) glycyrrhizic acid or a salt thereof is a stimulant, astringent or unpleasant mitigating / suppressing agent derived from the component (A).
Examples of the component (B) glycyrrhizic acid or a salt thereof include glycyrrhizic acid, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, and diammonium glycyrrhizinate. Among these, dipotassium glycyrrhizinate is particularly preferable from the viewpoint of solubility in water and taste.
In the present invention, a plant containing glycyrrhizic acid or a salt thereof as the component (B), for example, herbal medicines such as licorice and licorice extract can be blended.

  The amount of component (B) is preferably 0.001 to 0.25%, more preferably 0.01 to 0.2% of the entire composition. If it is less than 0.001%, the irritation may be alleviated and the usability improvement effect may be poor. If it exceeds 0.25%, the astringent taste or off-flavor derived from the component (B) may be strongly produced and the feeling of use may be impaired.

  In the present invention, it is important for formulating the effects that the components (A) and (B) are blended in an appropriate ratio. In this case, component (B) / component (A) is 0.15-20 as a mass ratio, Preferably it is 0.2-10. When the ratio is less than 0.15, the effect of suppressing the irritation of component (A) and improving the feeling of use (astringency and taste) are not sufficiently obtained. If it exceeds 20, the astringency, nasty taste, etc. of the component (B) itself become strong and the feeling of use is inferior.

  The composition of the present invention preferably further contains (C) a component selected from vanilla absolute, vanillin, ethyl vanillin, and nutmeg oil. When a component (C) is mix | blended, the irritation | stimulation of component (A), an astringent taste, and a nasty taste are masked, and a usability | use_condition can be improved more.

  As the vanillin and ethyl vanillin, for example, commercially available products such as “Wanilin” manufactured by Toyoda Fragrance Co., Ltd., and “Ethyl Vanillin” manufactured by Kamata Fragrance Co., Ltd. can be used.

Vanilla absolute can be obtained, for example, by solvent extraction of vanilla beans by the following method. Commercial products can also be used.
Vanilla beans are extracted with an organic solvent (benzene, acetone, hexane, petroleum ether, etc.), and the solvent is distilled off (reduced pressure) to obtain vanilla oleoresin. This is extracted with a solvent (ethanol), cooled, the insoluble matter is filtered, and then the solvent is distilled off (reduced pressure) to obtain vanilla absolute. A solution diluted with a solvent such as ethanol, jojoba oil, or medium chain fatty acid ester can also be used.
As a commercial item, the brand name "Vanilla absolute (50% ethanol dilution product)" by the Kamata perfume company can be used, for example.

  Nutmeg oil can be obtained by steam distillation of nutmeg (Nutmeg, Nutaceae, scientific name: Myristica fragrance Hout.) Seeds. A commercial item can also be used, for example, "Nutmeg Oil" manufactured by We Mann Fis Fragrance Co., Ltd. can be used.

  Component (C) can be used alone or in combination of two or more of the above compounds. In particular, vanilla absolute alone or a combination of vanilla absolute and one or more selected from vanillin, ethyl vanillin, and nutmeg oil is preferable in terms of effect. When using 2 or more types together, the combined use of vanilla absolute and nutmeg oil is particularly preferable.

  When mix | blending a component (C), the compounding quantity is 0.0000001 to 0.004% of the whole composition, More preferably, it is 0.0000004 to 0.00075%. If it is less than 0.0000001%, the effect of alleviating irritation and improving the feeling of use may not be exhibited satisfactorily. If it exceeds 0.004%, the feeling of use may be impaired by the flavor of itself.

  Component (C) / component (A) has a mass ratio of preferably 0.0000002 to 0.6, more preferably 0.000004 to 0.3, and still more preferably 0.000008 to 0.05. If it is less than 0.0000002, the use feeling improvement effect may not be sufficiently obtained. When it exceeds 0.6, the flavor characteristic of component (C) itself may become strong and may be inferior to a feeling of use.

The composition of the present invention can further contain a cationic fungicide.
As the cationic disinfectant, one or more of cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride and the like can be used, and cetylpyridinium chloride and benzethonium chloride are particularly preferable, and chloride is particularly preferable in terms of usability. More preferred is cetylpyridinium.

When mix | blending a cationic disinfectant, the compounding quantity has preferable 0.005-0.1% of the whole composition, More preferably, it is 0.01-0.08%. If it is less than 0.005%, the blending effect may not be recognized. If it exceeds 0.1%, astringent taste and off-taste derived from the cationic fungicide may occur, and the feeling in use may be impaired.
Moreover, 0.01 to 0.1% of the whole composition is preferable, and, as for the compounding quantity of a cetyl pyridinium chloride, More preferably, it is 0.02 to 0.08%.
The blending amount of benzethonium chloride is preferably 0.005 to 0.1%, more preferably 0.008 to 0.05% of the total composition.

  The composition of the present invention is particularly suitably prepared as a liquid oral composition in which the compounding components are solubilized. The composition of the present invention is also effective in paste-form preparations such as dentifrices. However, compared with such preparations, liquid preparations such as mouthwashes and liquid dentifrices are particularly irritating and astringent. -Although a nasty taste is strongly expressed, according to this invention, an irritation feeling can be eased with such a liquid formulation, and astringency and nasty taste can be suppressed. Specifically, it is prepared and applied as a mouthwash of the type that is used as it is, a freshener in the mouth, a mouthwash that is diluted at the time of use in a concentrated type, and a liquid dentifrice that is used by brushing with a toothbrush. And is particularly suitable as a mouthwash.

  In addition to the above-mentioned components, other known components can be blended in the composition of the present invention as necessary within a range not impeding the effects of the present invention. Specifically, the liquid oral composition contains a wetting agent, a surfactant, a solvent, and if necessary, a sweetener, a coloring agent, a fragrance, an active ingredient, and the like. In addition, it is preferable that solid components which do not solubilize, such as an abrasive | polishing agent, are not normally mix | blended with a liquid oral composition, and an abrasive | polishing agent is not included.

  Examples of the wetting agent include sugar alcohols such as sorbitol, malt, and lactit, and polyhydric alcohols such as glycerin, ethylene glycol, and polyethylene glycol. The blending amount of these wetting agents is preferably 2 to 20% of the total composition.

  As the surfactant, known anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants can be blended, and it is particularly preferable to blend nonionic surfactants.

  Anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid N-acyl glutamate such as sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Is mentioned.

  Nonionic surfactants include, for example, sugar alcohol fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, and alkylol amide. And polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester, hexaglyceryl monocetylate, fatty acid diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether and the like.

Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 60 to 100 moles, an average addition mole of ethylene oxide having 16 (cetyl) to 18 (stearyl) carbon atoms in the alkyl group. 1 type selected from polyoxyethylene alkyl ether having a number of 20 to 40 moles, decaglycerin monofatty acid ester of fatty acid having 12 (lauric acid) to 18 (stearic acid), particularly 12 to 14 (myristic acid) Two or more are preferred. Among them, polyoxyethylene hydrogenated castor oil is preferable in terms of sufficiently exerting the adhesion inhibitory effect of dental plaque on the tooth surface and appearance stability (no orientation), and in particular, the average added mole number of ethylene oxide is The thing of 60-100 mol is preferable. When the average added mole number of ethylene oxide is less than 60 mol, especially in a liquid preparation, orientation may occur in a product stored at 50 ° C., and appearance stability (no orientation) may be impaired. Those exceeding 100 mol are generally not commercially available.
As the polyoxyethylene hydrogenated castor oil, commercially available products such as NIKKOL HCO system manufactured by Nikko Chemicals, Emarex HC system manufactured by Nihon Emulsion Co., Ltd., UNIOX HC system manufactured by NOF Corporation, and the like can be used.
As the polyoxyethylene alkyl ether, commercially available products such as Emarex 100 series and Emarex 600 series manufactured by Nikko Chemicals can be used.
As the decaglycerin monofatty acid ester, commercially available products such as NIKKOL Decagln series manufactured by Nikko Chemicals, Ryoto (registered trademark) polyglycerester D series manufactured by Mitsubishi Chemical Foods, Inc. can be used.

Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Amphoteric surfactants include betaine acetate type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine, and imidazoline type such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt. Examples include amphoteric surfactants.
The blending amount of these surfactants is preferably 0.05 to 5% of the entire composition.

As a sweetening agent, xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame and the like can be blended.
As a colorant, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and the like can be added.

  As a fragrance, natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, winter green oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, lavender oil, paracres oil, And l-menthol, l-carvone, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, eugenol, menthyl acetate, citral, camphor, borneol, pinene, spirantol, etc. Perfume ingredients contained in natural essential oils, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzaldehyde Perfume ingredients such as, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol 1-menthyl carbonate, One of the flavors of apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc. Or 2 or more types can be added in the range which does not inhibit the effect of this invention. The addition amount is usually 0.00001 to 3% in the composition.

  Active ingredients include, for example, bactericides such as isopropyl methyl cellulose, enzymes such as dextranase and mutanase, fluorides such as sodium fluoride and sodium monofluorophosphate, aluminum chlorohydroxy allantoin, allantoin, azulene, lysozyme chloride, ascorbic acid Such as vitamin C, dihydrocholesterol, glycyrrhetin salts, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, ougon, clove, hamamelis, etc. plant extracts, copper gluconate, caropeptide, sodium polyphosphate, water-soluble inorganic phosphate compounds Polyvinyl pyrrolidone, calculus inhibitor, dental plaque inhibitor, potassium nitrate, aluminum lactate and the like can be added. In addition, the addition amount of these active ingredients can be made into effective amount in the range which does not prevent the effect of this invention.

  As the solvent, water is usually used, and the water content is preferably 60% or more of the total composition. Further, a lower monohydric alcohol such as ethanol may be blended within a range not impeding the effects of the present invention, but when added, it is preferably 10% or less of the entire composition. In addition, it is preferable not to mix | blend ethanol from the point of irritation | stimulation.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Liquid oral compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in Tables 1-3.

(1) No sense of irritation The sample (liquid oral composition) contains about 10 ml in the mouth, rinsed for 30 seconds, and then evaluated for lack of irritation after mouthwash in the following 5 levels. Are indicated by ☆, ◎, ○, Δ, × in accordance with the following criteria.
Evaluation criteria for lack of irritation:
5 points: There was no irritation.
4 points: There was no irritation.
3 points: There was a slight irritation.
2 points: There was some irritation.
1 point: There was considerable irritation.
Criteria for lack of irritation:
☆: Average point 4.5 points or more and 5.0 points or less ◎: Average point 4.0 points or more and less than 4.5 points ○: Average point 3.0 points or more and less than 4.0 points △: Average point 2.0 points More than less than 3.0 points x: Average point less than 2.0 points

(2) Feeling of use (no astringency or taste)
About 10 ml of sample (liquid oral composition) is included in the mouth, rinsed for 30 seconds, and then evaluated for the astringency and unpleasantness after mouthwash in the following 5 levels. , ☆, ◎, ○, △, ×.
Evaluation criteria for astringency and tastelessness:
5 points: There was no astringency or taste, and the feeling of use was very good.
4 points: There was almost no astringency and unpleasant taste, and the feeling of use was good.
3 points: Slight astringency and a bitter taste, but there was no problem with the feeling of use.
2 points: Some astringency and nasty taste, slightly inferior to the feeling of use.
1 point: There was a lot of astringency and nasty taste, and the feeling of use was inferior.
Judgment criteria for astringency and tastelessness:
☆: Average point 4.5 points or more and 5.0 points or less ◎: Average point 4.0 points or more and less than 4.5 points ○: Average point 3.0 points or more and less than 4.0 points △: Average point 2.0 points More than less than 3.0 points x: Average point less than 2.0 points

The details of the raw materials used are as follows.
Calcium glycerophosphate (Iwaki Pharmaceutical Co., Ltd.)
Dipotassium glycyrrhizinate (Maruzen Pharmaceutical Co., Ltd.)
β-glycyrrhetinic acid (manufactured by Maruzen Pharmaceutical Co., Ltd.)
Azulene sulfonate sodium (Alps Pharmaceutical Co., Ltd.)
Vanillin (made by Toyoda Fragrance)
Ethyl vanillin (manufactured by Iwata Inc.)
Vanilla absolute 50% diluted product (vanilla absolute (50% ethanol diluted product), manufactured by Iwata Inc.)
Nutmeg oil (manufactured by We Mann Fis Fragrance)
Cetylpyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.)
Benzethonium chloride (Highamine 1622: Lonza Japan)
Polyoxyethylene (60) hardened castor oil, polyoxyethylene (100) hardened castor oil (manufactured by Nikko Chemicals)
Propylene glycol (Asahi Glass Co., Ltd.)
Glycerin (85%, Sakamoto Pharmaceutical Co., Ltd.)
Xylitol (Rocket Fleure)
Citric acid (manufactured by Komatsuya)
Sodium citrate (manufactured by Komatsuya)
Saccharin sodium (Daito Chemical Co., Ltd.)
Ethanol (Shinwa Alcohol)
As other ingredients, those conforming to the quasi-drug raw material standard 2006 were used.
Moreover, a fragrance | flavor composition is as showing to Table 4-10 mentioned later. The perfume composition A does not contain vanillin, ethyl vanillin, vanilla absolute, or nutmeg oil.

＊１；（ ）内の数値はバニラアブソリュート純品の％を示す（以下、同様。）。

* 1; Figures in parentheses indicate the percentage of vanilla absolute pure product (the same applies hereinafter).

  A prescription example is shown below. The oral compositions of these prescription examples all had a good feeling of use because the irritation of glycerophosphoric acid and its salts was suppressed, and the astringency and taste were improved.

[Prescription Example 1] Mouthwash (A) Calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.015
(C) Vanilla absolute 50% diluted product 0.000004
(0.000002 ^{* 1} )
Cetylpyridinium chloride 0.05
Polyoxyethylene (100) hardened castor oil 0.5
Glycerin 4.5
Propylene glycol 3
Xylitol 3
Saccharin sodium 0.004
Fragrance composition A 0.2
Citric acid 0.03
Sodium citrate 0.25
Methyl paraoxybenzoate 0.1
Ethyl paraoxybenzoate 0.05
Purified water balance
Total 100.0%
(B) / (A) = 0.3

[Formulation Example 2] mouthwash (A) calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.02
(C) Vanillin 0.000003
Cetylpyridinium chloride 0.05
Polyoxyethylene (60) hydrogenated castor oil 0.5
Glycerin 5
Propylene glycol 2.5
Xylitol 4
Saccharin sodium 0.002
Fragrance composition A 0.3
Citric acid 0.05
Sodium citrate 0.2
Methyl paraoxybenzoate 0.05
Ethyl paraoxybenzoate 0.1
Purified water balance
Total 100.0%
(B) / (A) = 0.4

[Prescription Example 3] Liquid Dentifrice (A) Calcium Glycerophosphate 0.03
(B) Dipotassium glycyrrhizinate 0.05
(C) Ethyl vanillin 0.0000008
Cetylpyridinium chloride 0.05
Lauroyl sarcosine sodium 0.1
Polyoxyethylene (100) hydrogenated castor oil 0.4
Glycerin 8
Propylene glycol 2
Xylitol 2.5
Erythritol 2.5
Sucralose 0.001
Fragrance composition A 0.15
Citric acid 0.04
Sodium citrate 0.3
Methyl paraoxybenzoate 0.08
Sodium benzoate 0.2
Purified water balance
Total 100.0%
(B) / (A) = 1.7

[Prescription Example 4] Liquid Dentifrice (A) Calcium Glycerophosphate 0.03
(B) Dipotassium glycyrrhizinate 0.2
(C) Vanilla absolute 50% diluted product 0.000001
(0.0000005 ^{* 1} )
(C) Nutmeg oil 0.0000005
Cetylpyridinium chloride 0.05
Isopropylmethylphenol 0.01
Sodium fluoride 0.1
Polyoxyethylene (60) hydrogenated castor oil 0.7
Glycerin 3
Propylene glycol 2
Polyethylene glycol 400 2
Xylitol 6
Saccharin sodium 0.001
Fragrance composition A 0.3
Citric acid 0.02
Sodium citrate 0.2
Methyl paraoxybenzoate 0.02
Ethyl paraoxybenzoate 0.05
Sodium benzoate 0.3
Purified water balance
Total 100.0%
(B) / (A) = 6.7

[Prescription Example 5] Mouthwash (A) Calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.03
(C) Vanillin 0.0000003
(C) Nutmeg oil 0.0000003
Cetylpyridinium chloride 0.05
Benzethonium chloride 0.01
Sodium fluoride 0.1
Polyoxyethylene (100) hydrogenated castor oil 0.3
Glycerin 5
Propylene glycol 5
Erythritol 5
Xylitol 6
Saccharin sodium 0.002
Fragrance composition A 0.25
Citric acid 0.03
Sodium citrate 0.35
Methyl paraoxybenzoate 0.15
Ethyl paraoxybenzoate 0.01
Purified water balance
Total 100.0%
(B) / (A) = 0.6

[Prescription Example 6] Mouthwash (A) Calcium glycerophosphate 0.04
(B) Dipotassium glycyrrhizinate 0.15
(C) Vanilla absolute 50% diluted product 0.0000008
(0.0000004 ^{* 1} )
(C) Ethyl vanillin 0.0000001
Benzethonium chloride 0.07
Isopropylmethylphenol 0.01
Polyoxyethylene (60) hydrogenated castor oil 0.6
Glycerin 5
Polyethylene glycol 400 5
Xylitol 2
Erythritol 2
Sucralose 0.001
Fragrance composition A 0.3
Citric acid 0.01
Sodium citrate 0.3
Methyl paraoxybenzoate 0.1
Sodium benzoate 0.1
Purified water balance
Total 100.0%
(B) / (A) = 3.8

[Prescription Example 7] Liquid Dentifrice (A) Calcium Glycerophosphate 0.15
(B) Dipotassium glycyrrhizinate 0.1
(C) Nutmeg oil 0.0001
Benzethonium chloride 0.1
Sodium fluoride 0.1
Polyoxyethylene (100) hardened castor oil 0.5
Glycerin 4.5
Propylene glycol 3
Xylitol 2
Saccharin sodium 0.005
Fragrance composition A 0.2
Citric acid 0.03
Sodium citrate 0.25
Sodium benzoate 0.4
Purified water balance
Total 100.0%
(B) / (A) = 0.7

[Prescription Example 8] Liquid Dentifrice (Double-layer preparation)
Oil layer Tocopherol acetate 0.1
Liquid paraffin 25
Fragrance composition A 0.2
(C) Vanilla absolute 50% diluted product 0.000002
(0.000001 ^{* 1} )
Aqueous layer (A) Calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.015
Glycerin 8
Propylene glycol 2
Sodium tripolyphosphate 0.3
Sodium carboxymethylcellulose 0.4
Xylitol 0.2
Saccharin sodium 0.001
Disodium hydrogen phosphate 0.5
Sodium dihydrogen phosphate 0.05
Methyl paraoxybenzoate 0.1
Sodium benzoate 0.2
Legal dyes (Red 106, 102, Blue 1, Green 3) 0.00002
Purified water balance
Total 100.0%
(B) / (A) = 0.3

[Prescription Example 9] Liquid dentifrice (double-layer preparation)
Oil layer Isopropylmethylphenol 0.001
Liquid paraffin 10
Tri (caprylic / capric) glyceryl 25
Fragrance composition A 0.3
(C) Vanillin 0.0000006
Aqueous layer (A) Calcium glycerophosphate 0.1
(B) Dipotassium glycyrrhizinate 0.1
Benzethonium chloride 0.002
Sodium fluoride 0.1
Glycerin 5
Propylene glycol 4
Sodium tripolyphosphate 0.5
Sodium pyrophosphate 0.1
Sodium carboxymethylcellulose 0.2
Hydroxyethyl cellulose 0.1
Xylitol 1
Sorbitol 2
Disodium hydrogen phosphate 0.7
Sodium dihydrogen phosphate 0.05
Methyl paraoxybenzoate 0.04
Sodium benzoate 0.4
Legal dye (Red No. 106, No. 102, Blue No. 1, Green No. 3) 0.00004
Purified water balance
Total 100.0%
(B) / (A) = 1.0

[Prescription Example 10] Mouthwash (two-layer preparation)
Oil layer Liquid paraffin 30
Jojoba oil 5
Fragrance composition A 0.2
(C) Vanilla absolute 50% diluted product 0.0000006
(0.0000003 ^{* 1} )
(C) Nutmeg oil 0.0000005
Aqueous layer (A) Calcium glycerophosphate 0.03
(B) Dipotassium glycyrrhizinate 0.2
Cetylpyridinium chloride 0.001
Benzalkonium chloride 0.005
Epsilon aminocaproic acid 0.004
Glycerin 7
Propylene glycol 3
Sodium tripolyphosphate 0.2
Sodium pyrophosphate 0.5
Sodium carboxymethylcellulose 0.1
Hydroxypropyl cellulose 0.2
Xylitol 0.5
Disodium hydrogen phosphate 0.6
Sodium dihydrogen phosphate 0.07
Methyl paraoxybenzoate 0.07
Sodium benzoate 0.3
Legal dyes (Red 106, 102, Blue 1, Green 3) 0.00002
Purified water balance
Total 100.0%
(B) / (A) = 6.7

表中、部は質量部である（以下、同様。）。

In the table, parts are parts by mass (the same applies hereinafter).

Claims (7)

(A) 0.01 to 0.2% by mass of glycerophosphoric acid or a salt thereof and (B) 0.01 to 0.2% by mass of glycyrrhizic acid or a salt thereof, (B) / (A) Is a composition for oral cavity, wherein the mass ratio is 0.2 to 10 . The oral composition of claim 1 wherein component (A) is calcium glycerophosphate. The composition for oral cavity according to claim 1 or 2, wherein the component (B) is dipotassium glycyrrhizinate. Further, (C) vanilla absolute, vanillin, of any one of claims 1 to 3 in which one or more components selected from ethyl vanillin and nutmeg oil containing from 0.0000001 to 0.004 wt% Oral composition. The composition for oral cavity according to claim 4, wherein the component (C) / component (A) is 0.0000002 to 0.6 as a mass ratio.   It is a liquid, The composition for oral cavity of any one of Claims 1-5. The composition for oral cavity according to claim 6, which is a mouthwash.